Motif 233 (n=200)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1A5D9 | BICDL2 | S331 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
| A4D1S0 | KLRG2 | S158 | ochoa | Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B) | None |
| A5PL33 | KRBA1 | S493 | ochoa | Protein KRBA1 | None |
| A6NC98 | CCDC88B | S1370 | ochoa | Coiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3) | Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (PubMed:25762780). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099). {ECO:0000250|UniProtKB:Q4QRL3, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:25762780}. |
| A6NF01 | POM121B | S210 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | S603 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| A8K0R7 | ZNF839 | S348 | ochoa | Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) | None |
| A8MYA2 | CXorf49; | S448 | ochoa | Uncharacterized protein CXorf49 | None |
| B4DS77 | SHISA9 | S337 | ochoa | Protein shisa-9 | Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). {ECO:0000250}. |
| O00267 | SUPT5H | S959 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O00512 | BCL9 | S291 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O00512 | BCL9 | S687 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O00512 | BCL9 | S878 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14976 | GAK | S770 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O43312 | MTSS1 | S721 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43426 | SYNJ1 | S1392 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O60285 | NUAK1 | S455 | ochoa | NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) | Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:12409306, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15060171, ECO:0000269|PubMed:15273717, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:20354225, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}. |
| O60336 | MAPKBP1 | S1367 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60641 | SNAP91 | S313 | ochoa|psp | Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20) | Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}. |
| O60716 | CTNND1 | S651 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O75179 | ANKRD17 | S1709 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
| O75969 | AKAP3 | S208 | ochoa | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}. |
| O94913 | PCF11 | S728 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94913 | PCF11 | S777 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O95359 | TACC2 | S137 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95487 | SEC24B | S556 | ochoa | Protein transport protein Sec24B (SEC24-related protein B) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O95996 | APC2 | S2025 | ochoa | Adenomatous polyposis coli protein 2 (Adenomatous polyposis coli protein-like) (APC-like) | Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329). {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}. |
| P04792 | HSPB1 | S158 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P08235 | NR3C2 | S196 | psp | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}. |
| P0C7T5 | ATXN1L | S206 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P17600 | SYN1 | S39 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P19484 | TFEB | S423 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P19878 | NCF2 | S332 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P25054 | APC | S2350 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P27815 | PDE4A | S128 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P28698 | MZF1 | S177 | ochoa | Myeloid zinc finger 1 (MZF-1) (Zinc finger and SCAN domain-containing protein 6) (Zinc finger protein 42) | Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. {ECO:0000269|PubMed:15541732, ECO:0000269|PubMed:17851584}. |
| P35548 | MSX2 | S123 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P48200 | IREB2 | S157 | psp | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2) | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}. |
| P48382 | RFX5 | S185 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49023 | PXN | S178 | psp | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49327 | FASN | S1174 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49716 | CEBPD | S167 | psp | CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) | Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16397300, PubMed:1741402). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). {ECO:0000269|PubMed:1741402}. |
| P51531 | SMARCA2 | S329 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51608 | MECP2 | S229 | ochoa|psp | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P51610 | HCFC1 | S1205 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P54259 | ATN1 | S358 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P57772 | EEFSEC | S537 | ochoa | Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) | Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons (PubMed:27708257, PubMed:35709277). Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon (PubMed:27708257, PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277). {ECO:0000269|PubMed:27708257, ECO:0000269|PubMed:35709277}. |
| P78352 | DLG4 | S295 | psp | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}. |
| P78524 | DENND2B | S84 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| P78559 | MAP1A | S1818 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P79522 | PRR3 | S33 | ochoa | Proline-rich protein 3 (MHC class I region proline-rich protein CAT56) | None |
| P98171 | ARHGAP4 | S906 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| P98174 | FGD1 | S82 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q04637 | EIF4G1 | S314 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q04759 | PRKCQ | S348 | ochoa | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation (PubMed:21964608). Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:8657160}. |
| Q12770 | SCAP | S952 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q13322 | GRB10 | T155 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13370 | PDE3B | S73 | psp | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}. |
| Q13435 | SF3B2 | S655 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13443 | ADAM9 | S758 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q13541 | EIF4EBP1 | S83 | ochoa|psp | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q13542 | EIF4EBP2 | S83 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q14687 | GSE1 | S572 | ochoa | Genetic suppressor element 1 | None |
| Q14690 | PDCD11 | S144 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q147X3 | NAA30 | S89 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14807 | KIF22 | S427 | ochoa|psp | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q14865 | ARID5B | S688 | ochoa | AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2) | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. |
| Q14966 | ZNF638 | S420 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14980 | NUMA1 | S169 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15013 | MAD2L1BP | S102 | ochoa|psp | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}. |
| Q15583 | TGIF1 | S95 | ochoa | Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Q15583 | TGIF1 | S291 | ochoa | Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Q15596 | NCOA2 | S1072 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15699 | ALX1 | S69 | ochoa | ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) | Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509). {ECO:0000269|PubMed:20451171, ECO:0000269|PubMed:23288509, ECO:0000269|PubMed:8756334, ECO:0000269|PubMed:9753625}. |
| Q15788 | NCOA1 | S1185 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q17R89 | ARHGAP44 | S596 | ochoa | Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}. |
| Q2KJY2 | KIF26B | S1021 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M2I8 | AAK1 | S797 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q3KQU3 | MAP7D1 | S496 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q49AM3 | TTC31 | S464 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q4AC94 | C2CD3 | S2114 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q5QP82 | DCAF10 | S89 | ochoa | DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
| Q5R372 | RABGAP1L | S119 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5SV97 | PERM1 | S242 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5SYE7 | NHSL1 | S568 | ochoa | NHS-like protein 1 | None |
| Q5T200 | ZC3H13 | S77 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TGY3 | AHDC1 | S957 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VUA4 | ZNF318 | S1896 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWQ8 | DAB2IP | S995 | ochoa | Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein) | Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229, ECO:0000269|PubMed:29156729}. |
| Q69YU3 | ANKRD34A | S392 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
| Q6AI12 | ANKRD40 | S160 | ochoa | Ankyrin repeat domain-containing protein 40 | None |
| Q6DCA0 | AMMECR1L | S87 | ochoa | AMMECR1-like protein | None |
| Q6GPH4 | XAF1 | S253 | ochoa | XIAP-associated factor 1 (BIRC4-binding protein) | Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269|PubMed:11175744, ECO:0000269|PubMed:12029096, ECO:0000269|PubMed:16432762, ECO:0000269|PubMed:17329253, ECO:0000269|PubMed:17613533}. |
| Q6IBW4 | NCAPH2 | S200 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6IBW4 | NCAPH2 | S208 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6N043 | ZNF280D | S545 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P1R3 | MSANTD2 | S48 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6P3S6 | FBXO42 | S552 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6P4R8 | NFRKB | S887 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PII3 | CCDC174 | S437 | ochoa | Coiled-coil domain-containing protein 174 | Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}. |
| Q6PK04 | CCDC137 | S233 | ochoa | Coiled-coil domain-containing protein 137 | None |
| Q6Q6R5 | CRIP3 | S96 | ochoa | Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) | None |
| Q6UUV9 | CRTC1 | S312 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6W2J9 | BCOR | S1439 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZNJ1 | NBEAL2 | S1390 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZS30 | NBEAL1 | S734 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q70SY1 | CREB3L2 | S234 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q7RTP6 | MICAL3 | S1406 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z434 | MAVS | S165 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z591 | AKNA | S1377 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z6M1 | RABEPK | S133 | ochoa | Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40) | Rab9 effector required for endosome to trans-Golgi network (TGN) transport. {ECO:0000269|PubMed:9230071}. |
| Q86UU0 | BCL9L | S1017 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU0 | BCL9L | S1074 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86X51 | EZHIP | S259 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86XL3 | ANKLE2 | S919 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IU68 | TMC8 | S703 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q8IV53 | DENND1C | S711 | ochoa | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C) | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8IX21 | SLF2 | S568 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IY33 | MICALL2 | S318 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IYI8 | ZNF440 | S513 | ochoa | Zinc finger protein 440 | May be involved in transcriptional regulation. |
| Q8IZD2 | KMT2E | S1298 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZW8 | TNS4 | S404 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8IZY2 | ABCA7 | S804 | ochoa | Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter) | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}. |
| Q8N2R0 | OSR2 | S145 | ochoa | Protein odd-skipped-related 2 | May be involved in the development of the mandibular molar tooth germ at the bud stage. {ECO:0000250|UniProtKB:Q91ZD1}. |
| Q8N8Z6 | DCBLD1 | S640 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8ND30 | PPFIBP2 | S40 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8NDV7 | TNRC6A | S1372 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NDX1 | PSD4 | S448 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEA6 | GLIS3 | S545 | ochoa | Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) | Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. |
| Q8NHG8 | ZNRF2 | S151 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TAP8 | PPP1R35 | S52 | ochoa | Protein phosphatase 1 regulatory subunit 35 | During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. |
| Q8TDM6 | DLG5 | S1064 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8WUB8 | PHF10 | S27 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WWN8 | ARAP3 | S1474 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q92570 | NR4A3 | S390 | ochoa | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
| Q92786 | PROX1 | S467 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92888 | ARHGEF1 | S350 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q93052 | LPP | Y346 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96BF3 | TMIGD2 | S262 | ochoa|psp | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96C55 | ZNF524 | S24 | ochoa | Zinc finger protein 524 | May be involved in transcriptional regulation. |
| Q96FJ0 | STAMBPL1 | S242 | ochoa | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}. |
| Q96H86 | ZNF764 | S136 | ochoa | Zinc finger protein 764 | Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR (PubMed:28139699). Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes (PubMed:28139699). {ECO:0000269|PubMed:28139699}. |
| Q96HA1 | POM121 | S626 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96KQ4 | PPP1R13B | S681 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96PK6 | RBM14 | S220 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96RU7 | TRIB3 | S51 | ochoa | Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B) | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15775988, PubMed:15781252). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15775988, PubMed:15781252). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15775988, PubMed:15781252). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230). {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}. |
| Q96RY5 | CRAMP1 | S533 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99759 | MAP3K3 | S176 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q99929 | ASCL2 | S142 | ochoa | Achaete-scute homolog 2 (ASH-2) (hASH2) (Class A basic helix-loop-helix protein 45) (bHLHa45) (Mash2) | Transcription factor. Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells. May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (By similarity). {ECO:0000250|UniProtKB:O35885, ECO:0000250|UniProtKB:P19360}. |
| Q9BRQ0 | PYGO2 | S97 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| Q9BSA4 | TTYH2 | S504 | ochoa | Protein tweety homolog 2 (hTTY2) (Volume-regulated anion channel subunit TTYH2) | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q3TH73, ECO:0000269|PubMed:15010458}. |
| Q9BUR4 | WRAP53 | S54 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BWN1 | PRR14 | S42 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
| Q9BXF6 | RAB11FIP5 | S538 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXL5 | HEMGN | S123 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BYE2 | TMPRSS13 | S70 | ochoa | Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) | Serine protease (PubMed:20977675, PubMed:28710277, PubMed:34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed:34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed:20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity). {ECO:0000250|UniProtKB:Q5U405, ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451}. |
| Q9BZE0 | GLIS2 | S419 | ochoa | Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}. |
| Q9C0C2 | TNKS1BP1 | S311 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D0 | PHACTR1 | S237 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0H5 | ARHGAP39 | S286 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9H1V8 | SLC6A17 | S701 | ochoa | Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) | Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride-independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. {ECO:0000250|UniProtKB:P31662}. |
| Q9H2D6 | TRIOBP | S1228 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H3D4 | TP63 | S160 | psp | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. {ECO:0000269|PubMed:11641404, ECO:0000269|PubMed:12374749, ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:12446784, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:9774969}. |
| Q9H6S3 | EPS8L2 | S480 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H706 | GAREM1 | S546 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H7P9 | PLEKHG2 | S1227 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H7Z6 | KAT8 | S37 | ochoa | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9H9J4 | USP42 | S754 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HCH0 | NCKAP5L | S451 | psp | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}. |
| Q9HCK8 | CHD8 | S2008 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPI6 | DCP1A | S373 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NQU5 | PAK6 | S347 | ochoa|psp | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NR48 | ASH1L | S570 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRA0 | SPHK2 | S419 | psp | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| Q9NRA8 | EIF4ENIF1 | S797 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NUL3 | STAU2 | S416 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NWA0 | MED9 | S53 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9P219 | CCDC88C | S1981 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P227 | ARHGAP23 | S1230 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P270 | SLAIN2 | S467 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9UBI9 | HECA | S281 | ochoa | Headcase protein homolog (hHDC) | May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. {ECO:0000303|PubMed:11696983}. |
| Q9UBK2 | PPARGC1A | S313 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}. |
| Q9UF83 | None | S326 | ochoa | Uncharacterized protein DKFZp434B061 | None |
| Q9ULM3 | YEATS2 | S575 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UQQ2 | SH2B3 | S511 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y2F5 | ICE1 | S255 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2F5 | ICE1 | S1712 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K6 | USP20 | S373 | ochoa | Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) | Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis (PubMed:27801882, PubMed:29487085). Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination (PubMed:26839314). Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization (PubMed:27801882). Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1 (PubMed:29487085). Acts as a positive regulator for NF-kappa-B activation by TNF-alpha through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability (PubMed:32354117). Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) (PubMed:19424180). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 (PubMed:19424180). This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity (PubMed:15776016). Deubiquitinates MCL1, a pivotal member of the anti-apoptotic Bcl-2 protein family to regulate its stability (PubMed:35063767). Within the endoplasmic reticulum, participates with USP33 in the rescue of post-translationally targeted membrane proteins that are inappropriately ubiquitinated by the cytosolic protein quality control in the cytosol (PubMed:33792613). {ECO:0000269|PubMed:12056827, ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:15776016, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:26839314, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:32354117, ECO:0000269|PubMed:33792613, ECO:0000269|PubMed:35063767}. |
| Q9Y3Q8 | TSC22D4 | S62 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4F5 | CEP170B | S655 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5K3 | PCYT1B | S346 | ochoa | Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) | [Isoform 1]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:9593753}.; FUNCTION: [Isoform 2]: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912}. |
| Q9Y5W9 | SNX11 | S228 | ochoa | Sorting nexin-11 | Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes (PubMed:23615901). Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation (PubMed:26818531). {ECO:0000269|PubMed:23615901, ECO:0000269|PubMed:26818531}. |
| Q9Y666 | SLC12A7 | S40 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6J0 | CABIN1 | S2159 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6M4 | CSNK1G3 | S345 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| Q9Y6X8 | ZHX2 | S719 | ochoa | Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}. |
| O75925 | PIAS1 | S90 | iPTMNet | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| O15067 | PFAS | S1062 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q9NQR4 | NIT2 | S133 | Sugiyama | Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) | Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}. |
| Q96NW7 | LRRC7 | S1439 | SIGNOR|iPTMNet | Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000037 | 4.430 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000222 | 3.654 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000254 | 3.595 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000365 | 3.438 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.000752 | 3.124 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.000733 | 3.135 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.001292 | 2.889 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.001218 | 2.915 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.001369 | 2.864 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.002220 | 2.654 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.002361 | 2.627 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.003169 | 2.499 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.004275 | 2.369 |
| R-HSA-9843745 | Adipogenesis | 0.004414 | 2.355 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.003878 | 2.411 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.004162 | 2.381 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.005533 | 2.257 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.008493 | 2.071 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.008493 | 2.071 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.009118 | 2.040 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.013570 | 1.867 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.013974 | 1.855 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.012658 | 1.898 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.013651 | 1.865 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.013329 | 1.875 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.013329 | 1.875 |
| R-HSA-194138 | Signaling by VEGF | 0.013193 | 1.880 |
| R-HSA-4839726 | Chromatin organization | 0.012423 | 1.906 |
| R-HSA-74160 | Gene expression (Transcription) | 0.013081 | 1.883 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.020611 | 1.686 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.020611 | 1.686 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.020611 | 1.686 |
| R-HSA-3214847 | HATs acetylate histones | 0.018306 | 1.737 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.021122 | 1.675 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.020434 | 1.690 |
| R-HSA-9707616 | Heme signaling | 0.016178 | 1.791 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.016063 | 1.794 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.022020 | 1.657 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.016946 | 1.771 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.023063 | 1.637 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.023063 | 1.637 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.024564 | 1.610 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.025628 | 1.591 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.025628 | 1.591 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.027946 | 1.554 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.031929 | 1.496 |
| R-HSA-9659379 | Sensory processing of sound | 0.032370 | 1.490 |
| R-HSA-1989781 | PPARA activates gene expression | 0.032700 | 1.485 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.034278 | 1.465 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.033970 | 1.469 |
| R-HSA-5688426 | Deubiquitination | 0.036605 | 1.436 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.103560 | 0.985 |
| R-HSA-165160 | PDE3B signalling | 0.103560 | 0.985 |
| R-HSA-109703 | PKB-mediated events | 0.103560 | 0.985 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.139579 | 0.855 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.046479 | 1.333 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.162788 | 0.788 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.162788 | 0.788 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.053272 | 1.274 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.053272 | 1.274 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.174158 | 0.759 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.174158 | 0.759 |
| R-HSA-4839744 | Signaling by APC mutants | 0.174158 | 0.759 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.174158 | 0.759 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.174158 | 0.759 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.174158 | 0.759 |
| R-HSA-429947 | Deadenylation of mRNA | 0.064066 | 1.193 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.185374 | 0.732 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.071633 | 1.145 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.196438 | 0.707 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.196438 | 0.707 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.196438 | 0.707 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.196438 | 0.707 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.196438 | 0.707 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.196438 | 0.707 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.207353 | 0.683 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.083490 | 1.078 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.087566 | 1.058 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.091701 | 1.038 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.091701 | 1.038 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.228742 | 0.641 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.228742 | 0.641 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.100138 | 0.999 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.100138 | 0.999 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.104434 | 0.981 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.239220 | 0.621 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.239220 | 0.621 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.113173 | 0.946 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.131178 | 0.882 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.135778 | 0.867 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.279733 | 0.553 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.279733 | 0.553 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.289522 | 0.538 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.299177 | 0.524 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.318099 | 0.497 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.327368 | 0.485 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.228064 | 0.642 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.363207 | 0.440 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.363207 | 0.440 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.371865 | 0.430 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.371865 | 0.430 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.348269 | 0.458 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.162788 | 0.788 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.174158 | 0.759 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.299601 | 0.523 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.299601 | 0.523 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.303494 | 0.518 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.299601 | 0.523 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.371865 | 0.430 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.091223 | 1.040 |
| R-HSA-8963901 | Chylomicron remodeling | 0.207353 | 0.683 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.218120 | 0.661 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.259752 | 0.585 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.371865 | 0.430 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.091223 | 1.040 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.298478 | 0.525 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.249556 | 0.603 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.097718 | 1.010 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.371865 | 0.430 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.354429 | 0.450 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.140413 | 0.853 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.308702 | 0.510 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.249556 | 0.603 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.179772 | 0.745 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.053188 | 1.274 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.066039 | 1.180 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.066039 | 1.180 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.151263 | 0.820 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.174158 | 0.759 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.185374 | 0.732 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.185374 | 0.732 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.207353 | 0.683 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.249556 | 0.603 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.117612 | 0.930 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.122093 | 0.913 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.065029 | 1.187 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.269811 | 0.569 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.164060 | 0.785 |
| R-HSA-109704 | PI3K Cascade | 0.188343 | 0.725 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.336512 | 0.473 |
| R-HSA-9839394 | TGFBR3 expression | 0.345531 | 0.462 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.226530 | 0.645 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.141924 | 0.848 |
| R-HSA-5689603 | UCH proteinases | 0.318501 | 0.497 |
| R-HSA-9620244 | Long-term potentiation | 0.067814 | 1.169 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.083490 | 1.078 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.135778 | 0.867 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.135778 | 0.867 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.067814 | 1.169 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.067814 | 1.169 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.228742 | 0.641 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.104434 | 0.981 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.318099 | 0.497 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.100138 | 0.999 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.362995 | 0.440 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.056792 | 1.246 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.269811 | 0.569 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.373758 | 0.427 |
| R-HSA-165158 | Activation of AKT2 | 0.091223 | 1.040 |
| R-HSA-74713 | IRS activation | 0.091223 | 1.040 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.162788 | 0.788 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.185374 | 0.732 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.249556 | 0.603 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.249556 | 0.603 |
| R-HSA-112399 | IRS-mediated signalling | 0.223059 | 0.652 |
| R-HSA-191859 | snRNP Assembly | 0.233076 | 0.633 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.233076 | 0.633 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.371865 | 0.430 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.243121 | 0.614 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.308702 | 0.510 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.191571 | 0.718 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.336512 | 0.473 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.354429 | 0.450 |
| R-HSA-68875 | Mitotic Prophase | 0.112890 | 0.947 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.338389 | 0.471 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.096777 | 1.014 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.100138 | 0.999 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.108780 | 0.963 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.363207 | 0.440 |
| R-HSA-3371556 | Cellular response to heat stress | 0.281111 | 0.551 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.066039 | 1.180 |
| R-HSA-447038 | NrCAM interactions | 0.091223 | 1.040 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.127736 | 0.894 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.053272 | 1.274 |
| R-HSA-428540 | Activation of RAC1 | 0.185374 | 0.732 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.196438 | 0.707 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.228742 | 0.641 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.135778 | 0.867 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.135778 | 0.867 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.140413 | 0.853 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.173708 | 0.760 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.243121 | 0.614 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.076909 | 1.114 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.140413 | 0.853 |
| R-HSA-983189 | Kinesins | 0.238096 | 0.623 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.201818 | 0.695 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.056792 | 1.246 |
| R-HSA-199991 | Membrane Trafficking | 0.308488 | 0.511 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.103560 | 0.985 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.103560 | 0.985 |
| R-HSA-5682910 | LGI-ADAM interactions | 0.174158 | 0.759 |
| R-HSA-8963888 | Chylomicron assembly | 0.174158 | 0.759 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.218120 | 0.661 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.126616 | 0.898 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.299177 | 0.524 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.168872 | 0.772 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.114651 | 0.941 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.327368 | 0.485 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.327368 | 0.485 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.347862 | 0.459 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.115730 | 0.937 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.367876 | 0.434 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.259752 | 0.585 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.164474 | 0.784 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.258219 | 0.588 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.313506 | 0.504 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.145082 | 0.838 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.043388 | 1.363 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.177089 | 0.752 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.228742 | 0.641 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.239220 | 0.621 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.239220 | 0.621 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.131178 | 0.882 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.354429 | 0.450 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.156328 | 0.806 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.075520 | 1.122 |
| R-HSA-195721 | Signaling by WNT | 0.072344 | 1.141 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.263256 | 0.580 |
| R-HSA-212436 | Generic Transcription Pathway | 0.039190 | 1.407 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.240905 | 0.618 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.097718 | 1.010 |
| R-HSA-9909396 | Circadian clock | 0.053816 | 1.269 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.223059 | 0.652 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.350957 | 0.455 |
| R-HSA-74749 | Signal attenuation | 0.162788 | 0.788 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.058346 | 1.234 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.122093 | 0.913 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.248150 | 0.605 |
| R-HSA-9607240 | FLT3 Signaling | 0.140413 | 0.853 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.243121 | 0.614 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.140413 | 0.853 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.178566 | 0.748 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.122988 | 0.910 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.218120 | 0.661 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.058346 | 1.234 |
| R-HSA-211000 | Gene Silencing by RNA | 0.222963 | 0.652 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.100138 | 0.999 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.239220 | 0.621 |
| R-HSA-3214842 | HDMs demethylate histones | 0.345531 | 0.462 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.071633 | 1.145 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.363207 | 0.440 |
| R-HSA-211976 | Endogenous sterols | 0.243121 | 0.614 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.087566 | 1.058 |
| R-HSA-165159 | MTOR signalling | 0.149783 | 0.825 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.228742 | 0.641 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.358099 | 0.446 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.040038 | 1.398 |
| R-HSA-180292 | GAB1 signalosome | 0.269811 | 0.569 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.327368 | 0.485 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.082150 | 1.085 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.064066 | 1.193 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.075520 | 1.122 |
| R-HSA-5620971 | Pyroptosis | 0.371865 | 0.430 |
| R-HSA-8964058 | HDL remodeling | 0.279733 | 0.553 |
| R-HSA-162582 | Signal Transduction | 0.369455 | 0.432 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.362995 | 0.440 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.102010 | 0.991 |
| R-HSA-2262752 | Cellular responses to stress | 0.255719 | 0.592 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.318099 | 0.497 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.354429 | 0.450 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.178566 | 0.748 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.273744 | 0.563 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.100465 | 0.998 |
| R-HSA-8957322 | Metabolism of steroids | 0.330943 | 0.480 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.088612 | 1.053 |
| R-HSA-913531 | Interferon Signaling | 0.190571 | 0.720 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.108780 | 0.963 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.095893 | 1.018 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.336512 | 0.473 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.154514 | 0.811 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.353191 | 0.452 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.251648 | 0.599 |
| R-HSA-75153 | Apoptotic execution phase | 0.168872 | 0.772 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.218062 | 0.661 |
| R-HSA-5357801 | Programmed Cell Death | 0.369447 | 0.432 |
| R-HSA-109581 | Apoptosis | 0.233084 | 0.632 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.273330 | 0.563 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.191433 | 0.718 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.377595 | 0.423 |
| R-HSA-72086 | mRNA Capping | 0.380407 | 0.420 |
| R-HSA-180024 | DARPP-32 events | 0.380407 | 0.420 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.386512 | 0.413 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.388833 | 0.410 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.397144 | 0.401 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.397144 | 0.401 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.397144 | 0.401 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.397144 | 0.401 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.405344 | 0.392 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.405344 | 0.392 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.405344 | 0.392 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.406363 | 0.391 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.413432 | 0.384 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.413432 | 0.384 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.413432 | 0.384 |
| R-HSA-73887 | Death Receptor Signaling | 0.417635 | 0.379 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.421410 | 0.375 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.421410 | 0.375 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.421410 | 0.375 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.421410 | 0.375 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.426775 | 0.370 |
| R-HSA-162587 | HIV Life Cycle | 0.428459 | 0.368 |
| R-HSA-9610379 | HCMV Late Events | 0.428459 | 0.368 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.429281 | 0.367 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.429844 | 0.367 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.437045 | 0.359 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.439212 | 0.357 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.439717 | 0.357 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.443696 | 0.353 |
| R-HSA-3371511 | HSF1 activation | 0.444704 | 0.352 |
| R-HSA-8853659 | RET signaling | 0.444704 | 0.352 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.444704 | 0.352 |
| R-HSA-70171 | Glycolysis | 0.448272 | 0.348 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.452259 | 0.345 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.452259 | 0.345 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.457361 | 0.340 |
| R-HSA-8875878 | MET promotes cell motility | 0.459712 | 0.338 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.459712 | 0.338 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.466363 | 0.331 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.466363 | 0.331 |
| R-HSA-8939211 | ESR-mediated signaling | 0.466656 | 0.331 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.467064 | 0.331 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.467064 | 0.331 |
| R-HSA-9648002 | RAS processing | 0.467064 | 0.331 |
| R-HSA-9833110 | RSV-host interactions | 0.470831 | 0.327 |
| R-HSA-68886 | M Phase | 0.473172 | 0.325 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.474316 | 0.324 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.474316 | 0.324 |
| R-HSA-167169 | HIV Transcription Elongation | 0.474316 | 0.324 |
| R-HSA-3371568 | Attenuation phase | 0.474316 | 0.324 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.474316 | 0.324 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.475277 | 0.323 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.481470 | 0.317 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.481470 | 0.317 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.481470 | 0.317 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.484100 | 0.315 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.484100 | 0.315 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.488290 | 0.311 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.488527 | 0.311 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.495135 | 0.305 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.495489 | 0.305 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.497162 | 0.304 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.505753 | 0.296 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.505753 | 0.296 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.509130 | 0.293 |
| R-HSA-373752 | Netrin-1 signaling | 0.509130 | 0.293 |
| R-HSA-2559583 | Cellular Senescence | 0.512046 | 0.291 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.515812 | 0.288 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.522404 | 0.282 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.522404 | 0.282 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.522404 | 0.282 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.522404 | 0.282 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.522404 | 0.282 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.522648 | 0.282 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.526811 | 0.278 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.528907 | 0.277 |
| R-HSA-1483191 | Synthesis of PC | 0.528907 | 0.277 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.530950 | 0.275 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.530950 | 0.275 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.535064 | 0.272 |
| R-HSA-70326 | Glucose metabolism | 0.535064 | 0.272 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.535321 | 0.271 |
| R-HSA-9766229 | Degradation of CDH1 | 0.541648 | 0.266 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.547890 | 0.261 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.554047 | 0.256 |
| R-HSA-2514856 | The phototransduction cascade | 0.554047 | 0.256 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.559228 | 0.252 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.559228 | 0.252 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.560120 | 0.252 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.560120 | 0.252 |
| R-HSA-72187 | mRNA 3'-end processing | 0.560120 | 0.252 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.560120 | 0.252 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.560120 | 0.252 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.560120 | 0.252 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.563167 | 0.249 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.566111 | 0.247 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.566111 | 0.247 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.566111 | 0.247 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.566111 | 0.247 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.566111 | 0.247 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.566111 | 0.247 |
| R-HSA-72649 | Translation initiation complex formation | 0.572021 | 0.243 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.572021 | 0.243 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.577851 | 0.238 |
| R-HSA-418597 | G alpha (z) signalling events | 0.577851 | 0.238 |
| R-HSA-446728 | Cell junction organization | 0.582253 | 0.235 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.582447 | 0.235 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.583602 | 0.234 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.583602 | 0.234 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.583602 | 0.234 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.583602 | 0.234 |
| R-HSA-177929 | Signaling by EGFR | 0.583602 | 0.234 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.584893 | 0.233 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.585746 | 0.232 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.589275 | 0.230 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.589275 | 0.230 |
| R-HSA-180786 | Extension of Telomeres | 0.600390 | 0.222 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.601175 | 0.221 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.605835 | 0.218 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.605835 | 0.218 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.605835 | 0.218 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.610758 | 0.214 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.611207 | 0.214 |
| R-HSA-1442490 | Collagen degradation | 0.611207 | 0.214 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.616505 | 0.210 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.616505 | 0.210 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.616505 | 0.210 |
| R-HSA-163685 | Integration of energy metabolism | 0.619228 | 0.208 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.621731 | 0.206 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.621731 | 0.206 |
| R-HSA-8848021 | Signaling by PTK6 | 0.621731 | 0.206 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.622762 | 0.206 |
| R-HSA-68882 | Mitotic Anaphase | 0.627002 | 0.203 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.628268 | 0.202 |
| R-HSA-6807070 | PTEN Regulation | 0.629756 | 0.201 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.629839 | 0.201 |
| R-HSA-418990 | Adherens junctions interactions | 0.632662 | 0.199 |
| R-HSA-167172 | Transcription of the HIV genome | 0.646819 | 0.189 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.646819 | 0.189 |
| R-HSA-5218859 | Regulated Necrosis | 0.646819 | 0.189 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.654482 | 0.184 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.656384 | 0.183 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.656384 | 0.183 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.656384 | 0.183 |
| R-HSA-162906 | HIV Infection | 0.657391 | 0.182 |
| R-HSA-2187338 | Visual phototransduction | 0.659984 | 0.180 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.661069 | 0.180 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.661069 | 0.180 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.661069 | 0.180 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.661069 | 0.180 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.665690 | 0.177 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.670249 | 0.174 |
| R-HSA-4086398 | Ca2+ pathway | 0.670249 | 0.174 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.674746 | 0.171 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.674746 | 0.171 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.674746 | 0.171 |
| R-HSA-1500931 | Cell-Cell communication | 0.675478 | 0.170 |
| R-HSA-917937 | Iron uptake and transport | 0.679182 | 0.168 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.685172 | 0.164 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.692132 | 0.160 |
| R-HSA-9711097 | Cellular response to starvation | 0.694217 | 0.159 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.700128 | 0.155 |
| R-HSA-9833482 | PKR-mediated signaling | 0.700475 | 0.155 |
| R-HSA-6806834 | Signaling by MET | 0.700475 | 0.155 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.704562 | 0.152 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.708593 | 0.150 |
| R-HSA-9609646 | HCMV Infection | 0.715086 | 0.146 |
| R-HSA-421270 | Cell-cell junction organization | 0.717416 | 0.144 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.720075 | 0.143 |
| R-HSA-5619102 | SLC transporter disorders | 0.720075 | 0.143 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.727942 | 0.138 |
| R-HSA-72306 | tRNA processing | 0.730966 | 0.136 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.731655 | 0.136 |
| R-HSA-418555 | G alpha (s) signalling events | 0.733633 | 0.135 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.735318 | 0.134 |
| R-HSA-8953854 | Metabolism of RNA | 0.736849 | 0.133 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.737786 | 0.132 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.738898 | 0.131 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.738898 | 0.131 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.742495 | 0.129 |
| R-HSA-202424 | Downstream TCR signaling | 0.742495 | 0.129 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.742495 | 0.129 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.743987 | 0.128 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.744240 | 0.128 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.746011 | 0.127 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.749479 | 0.125 |
| R-HSA-391251 | Protein folding | 0.752900 | 0.123 |
| R-HSA-168255 | Influenza Infection | 0.754166 | 0.123 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.754806 | 0.122 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.756274 | 0.121 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.762886 | 0.118 |
| R-HSA-157579 | Telomere Maintenance | 0.772470 | 0.112 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.772470 | 0.112 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.778644 | 0.109 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.781668 | 0.107 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.781668 | 0.107 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.784632 | 0.105 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.784651 | 0.105 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.784651 | 0.105 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.784651 | 0.105 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.787594 | 0.104 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.787594 | 0.104 |
| R-HSA-1483255 | PI Metabolism | 0.787594 | 0.104 |
| R-HSA-422475 | Axon guidance | 0.787962 | 0.103 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.793318 | 0.101 |
| R-HSA-9609690 | HCMV Early Events | 0.793318 | 0.101 |
| R-HSA-111885 | Opioid Signalling | 0.793359 | 0.101 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.801717 | 0.096 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.804082 | 0.095 |
| R-HSA-69239 | Synthesis of DNA | 0.804427 | 0.095 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.805931 | 0.094 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.807100 | 0.093 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.807100 | 0.093 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.807100 | 0.093 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.807100 | 0.093 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.809737 | 0.092 |
| R-HSA-202403 | TCR signaling | 0.812339 | 0.090 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.815634 | 0.089 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.819932 | 0.086 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.826882 | 0.083 |
| R-HSA-373760 | L1CAM interactions | 0.831913 | 0.080 |
| R-HSA-9675108 | Nervous system development | 0.834763 | 0.078 |
| R-HSA-73886 | Chromosome Maintenance | 0.843101 | 0.074 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.849211 | 0.071 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.863301 | 0.064 |
| R-HSA-1266738 | Developmental Biology | 0.867902 | 0.062 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.868839 | 0.061 |
| R-HSA-1640170 | Cell Cycle | 0.873114 | 0.059 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.873592 | 0.059 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.877579 | 0.057 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.881022 | 0.055 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.882542 | 0.054 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.891874 | 0.050 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.892173 | 0.050 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.896260 | 0.048 |
| R-HSA-69242 | S Phase | 0.897682 | 0.047 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.903179 | 0.044 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.903179 | 0.044 |
| R-HSA-112316 | Neuronal System | 0.903501 | 0.044 |
| R-HSA-69306 | DNA Replication | 0.904507 | 0.044 |
| R-HSA-877300 | Interferon gamma signaling | 0.912101 | 0.040 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.915484 | 0.038 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.917968 | 0.037 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.917968 | 0.037 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.919181 | 0.037 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.925533 | 0.034 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.927564 | 0.033 |
| R-HSA-597592 | Post-translational protein modification | 0.927745 | 0.033 |
| R-HSA-1483257 | Phospholipid metabolism | 0.930175 | 0.031 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.930507 | 0.031 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.941946 | 0.026 |
| R-HSA-983712 | Ion channel transport | 0.942744 | 0.026 |
| R-HSA-5617833 | Cilium Assembly | 0.943531 | 0.025 |
| R-HSA-68877 | Mitotic Prometaphase | 0.945828 | 0.024 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.946573 | 0.024 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.950832 | 0.022 |
| R-HSA-428157 | Sphingolipid metabolism | 0.951509 | 0.022 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.952176 | 0.021 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.952834 | 0.021 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.952834 | 0.021 |
| R-HSA-72172 | mRNA Splicing | 0.954123 | 0.020 |
| R-HSA-9679506 | SARS-CoV Infections | 0.956420 | 0.019 |
| R-HSA-397014 | Muscle contraction | 0.958937 | 0.018 |
| R-HSA-6798695 | Neutrophil degranulation | 0.960005 | 0.018 |
| R-HSA-388396 | GPCR downstream signalling | 0.962729 | 0.016 |
| R-HSA-8951664 | Neddylation | 0.963755 | 0.016 |
| R-HSA-73894 | DNA Repair | 0.966977 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.968009 | 0.014 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.968492 | 0.014 |
| R-HSA-72312 | rRNA processing | 0.968885 | 0.014 |
| R-HSA-15869 | Metabolism of nucleotides | 0.970565 | 0.013 |
| R-HSA-157118 | Signaling by NOTCH | 0.972156 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.976010 | 0.011 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.978317 | 0.010 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.978354 | 0.010 |
| R-HSA-416476 | G alpha (q) signalling events | 0.980052 | 0.009 |
| R-HSA-1280218 | Adaptive Immune System | 0.980273 | 0.009 |
| R-HSA-372790 | Signaling by GPCR | 0.981990 | 0.008 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.982643 | 0.008 |
| R-HSA-72766 | Translation | 0.985653 | 0.006 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.989536 | 0.005 |
| R-HSA-1474244 | Extracellular matrix organization | 0.992159 | 0.003 |
| R-HSA-449147 | Signaling by Interleukins | 0.993598 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 0.994362 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.995475 | 0.002 |
| R-HSA-109582 | Hemostasis | 0.995790 | 0.002 |
| R-HSA-9824446 | Viral Infection Pathways | 0.996116 | 0.002 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.996614 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.996898 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.996930 | 0.001 |
| R-HSA-168256 | Immune System | 0.997022 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.997332 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997332 | 0.001 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.997839 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.999593 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999851 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999865 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999963 | 0.000 |
| R-HSA-1643685 | Disease | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.830 | 0.717 | 1 | 0.806 |
CDK18 |
0.824 | 0.744 | 1 | 0.824 |
CDK19 |
0.823 | 0.716 | 1 | 0.816 |
P38G |
0.820 | 0.759 | 1 | 0.865 |
CDK17 |
0.818 | 0.746 | 1 | 0.856 |
CDK12 |
0.817 | 0.743 | 1 | 0.822 |
CDK13 |
0.816 | 0.741 | 1 | 0.800 |
P38D |
0.816 | 0.742 | 1 | 0.869 |
KIS |
0.816 | 0.656 | 1 | 0.749 |
CDK8 |
0.815 | 0.715 | 1 | 0.779 |
CDK7 |
0.814 | 0.724 | 1 | 0.778 |
JNK2 |
0.813 | 0.762 | 1 | 0.823 |
CDK3 |
0.813 | 0.651 | 1 | 0.848 |
DYRK2 |
0.811 | 0.689 | 1 | 0.717 |
ERK1 |
0.811 | 0.725 | 1 | 0.805 |
CDK16 |
0.808 | 0.704 | 1 | 0.842 |
CDK1 |
0.807 | 0.706 | 1 | 0.802 |
P38B |
0.807 | 0.731 | 1 | 0.787 |
CDK5 |
0.806 | 0.707 | 1 | 0.749 |
CDK9 |
0.805 | 0.718 | 1 | 0.792 |
DYRK4 |
0.803 | 0.677 | 1 | 0.816 |
CDK10 |
0.803 | 0.673 | 1 | 0.799 |
HIPK4 |
0.802 | 0.524 | 1 | 0.498 |
HIPK1 |
0.802 | 0.637 | 1 | 0.696 |
CDK14 |
0.802 | 0.707 | 1 | 0.783 |
JNK3 |
0.801 | 0.744 | 1 | 0.794 |
P38A |
0.797 | 0.710 | 1 | 0.716 |
DYRK1B |
0.797 | 0.649 | 1 | 0.772 |
HIPK3 |
0.794 | 0.625 | 1 | 0.669 |
CDK4 |
0.794 | 0.711 | 1 | 0.831 |
CLK3 |
0.792 | 0.472 | 1 | 0.465 |
CDK6 |
0.790 | 0.686 | 1 | 0.803 |
DYRK1A |
0.790 | 0.561 | 1 | 0.678 |
SRPK1 |
0.789 | 0.354 | -3 | 0.741 |
NLK |
0.787 | 0.663 | 1 | 0.502 |
ERK2 |
0.787 | 0.698 | 1 | 0.752 |
DYRK3 |
0.784 | 0.517 | 1 | 0.659 |
JNK1 |
0.782 | 0.664 | 1 | 0.822 |
SRPK2 |
0.779 | 0.302 | -3 | 0.669 |
MAK |
0.778 | 0.480 | -2 | 0.797 |
CLK2 |
0.777 | 0.392 | -3 | 0.728 |
CLK1 |
0.776 | 0.386 | -3 | 0.718 |
ERK5 |
0.773 | 0.378 | 1 | 0.412 |
CLK4 |
0.770 | 0.362 | -3 | 0.739 |
CDK2 |
0.768 | 0.512 | 1 | 0.674 |
PRP4 |
0.767 | 0.516 | -3 | 0.878 |
ICK |
0.766 | 0.356 | -3 | 0.810 |
MOK |
0.763 | 0.425 | 1 | 0.579 |
MTOR |
0.762 | 0.201 | 1 | 0.295 |
CDKL5 |
0.762 | 0.182 | -3 | 0.776 |
SRPK3 |
0.759 | 0.244 | -3 | 0.710 |
CDKL1 |
0.753 | 0.153 | -3 | 0.779 |
CDC7 |
0.749 | -0.046 | 1 | 0.119 |
COT |
0.748 | -0.061 | 2 | 0.811 |
AURC |
0.748 | 0.098 | -2 | 0.728 |
ERK7 |
0.748 | 0.260 | 2 | 0.554 |
PRKD1 |
0.747 | 0.033 | -3 | 0.807 |
NDR2 |
0.746 | 0.047 | -3 | 0.789 |
MOS |
0.744 | 0.023 | 1 | 0.158 |
ATR |
0.744 | -0.017 | 1 | 0.166 |
TBK1 |
0.743 | -0.102 | 1 | 0.097 |
PIM3 |
0.743 | 0.011 | -3 | 0.797 |
PRKD2 |
0.742 | 0.024 | -3 | 0.753 |
PRPK |
0.741 | -0.035 | -1 | 0.816 |
WNK1 |
0.741 | -0.044 | -2 | 0.884 |
MST4 |
0.740 | -0.012 | 2 | 0.838 |
PKN3 |
0.740 | -0.013 | -3 | 0.803 |
NEK6 |
0.739 | -0.028 | -2 | 0.781 |
SKMLCK |
0.739 | 0.035 | -2 | 0.880 |
MNK2 |
0.738 | 0.054 | -2 | 0.833 |
CHAK2 |
0.738 | -0.001 | -1 | 0.789 |
IKKE |
0.738 | -0.119 | 1 | 0.098 |
RSK2 |
0.738 | 0.018 | -3 | 0.748 |
P90RSK |
0.737 | 0.025 | -3 | 0.761 |
PDHK4 |
0.737 | -0.122 | 1 | 0.174 |
RSK3 |
0.737 | 0.014 | -3 | 0.747 |
ULK2 |
0.736 | -0.116 | 2 | 0.749 |
CAMK1B |
0.736 | -0.023 | -3 | 0.810 |
PKCD |
0.736 | 0.015 | 2 | 0.753 |
NUAK2 |
0.735 | 0.014 | -3 | 0.803 |
CAMLCK |
0.735 | 0.036 | -2 | 0.862 |
IKKB |
0.735 | -0.127 | -2 | 0.675 |
NIK |
0.734 | -0.025 | -3 | 0.821 |
NDR1 |
0.733 | -0.029 | -3 | 0.785 |
PDHK1 |
0.733 | -0.112 | 1 | 0.155 |
DAPK2 |
0.733 | 0.023 | -3 | 0.822 |
RAF1 |
0.733 | -0.182 | 1 | 0.110 |
GCN2 |
0.733 | -0.171 | 2 | 0.749 |
BMPR2 |
0.733 | -0.110 | -2 | 0.811 |
PKACG |
0.733 | 0.010 | -2 | 0.773 |
PAK6 |
0.733 | 0.039 | -2 | 0.770 |
PIM1 |
0.733 | 0.027 | -3 | 0.749 |
MAPKAPK3 |
0.733 | -0.029 | -3 | 0.746 |
AMPKA1 |
0.731 | -0.025 | -3 | 0.808 |
PKN2 |
0.731 | -0.042 | -3 | 0.792 |
IRE1 |
0.731 | -0.044 | 1 | 0.106 |
GRK1 |
0.731 | 0.031 | -2 | 0.689 |
PHKG1 |
0.731 | -0.015 | -3 | 0.784 |
PKCA |
0.730 | 0.035 | 2 | 0.707 |
AMPKA2 |
0.730 | -0.002 | -3 | 0.778 |
PKG2 |
0.730 | 0.044 | -2 | 0.736 |
PKACB |
0.730 | 0.057 | -2 | 0.738 |
MNK1 |
0.730 | 0.034 | -2 | 0.831 |
PRKD3 |
0.729 | 0.010 | -3 | 0.723 |
TGFBR2 |
0.729 | -0.075 | -2 | 0.697 |
SMG1 |
0.729 | -0.009 | 1 | 0.155 |
PKCB |
0.729 | 0.004 | 2 | 0.711 |
PKCZ |
0.729 | 0.017 | 2 | 0.759 |
MARK4 |
0.728 | -0.045 | 4 | 0.824 |
CAMK2D |
0.728 | -0.055 | -3 | 0.803 |
MLK2 |
0.728 | -0.024 | 2 | 0.786 |
NEK9 |
0.727 | -0.093 | 2 | 0.809 |
AKT2 |
0.727 | 0.055 | -3 | 0.677 |
MPSK1 |
0.727 | 0.086 | 1 | 0.176 |
AURB |
0.727 | 0.039 | -2 | 0.723 |
NEK7 |
0.727 | -0.155 | -3 | 0.799 |
RIPK3 |
0.727 | -0.119 | 3 | 0.674 |
PAK3 |
0.727 | -0.009 | -2 | 0.832 |
MAPKAPK2 |
0.727 | -0.015 | -3 | 0.703 |
P70S6KB |
0.727 | -0.002 | -3 | 0.755 |
SGK3 |
0.727 | 0.030 | -3 | 0.737 |
IKKA |
0.726 | -0.042 | -2 | 0.655 |
DSTYK |
0.726 | -0.170 | 2 | 0.821 |
TSSK1 |
0.726 | -0.034 | -3 | 0.830 |
LATS2 |
0.726 | -0.024 | -5 | 0.704 |
MLK3 |
0.726 | -0.010 | 2 | 0.710 |
PAK1 |
0.726 | 0.005 | -2 | 0.838 |
ULK1 |
0.725 | -0.122 | -3 | 0.777 |
WNK3 |
0.724 | -0.167 | 1 | 0.112 |
MLK1 |
0.724 | -0.129 | 2 | 0.775 |
PKCG |
0.724 | -0.010 | 2 | 0.703 |
BCKDK |
0.724 | -0.122 | -1 | 0.716 |
GRK7 |
0.724 | 0.040 | 1 | 0.135 |
CAMK2G |
0.724 | -0.117 | 2 | 0.735 |
MELK |
0.724 | -0.036 | -3 | 0.765 |
NIM1 |
0.723 | -0.069 | 3 | 0.721 |
RSK4 |
0.723 | 0.032 | -3 | 0.722 |
NEK2 |
0.723 | -0.064 | 2 | 0.799 |
DNAPK |
0.723 | -0.033 | 1 | 0.172 |
VRK2 |
0.723 | 0.134 | 1 | 0.209 |
GRK5 |
0.723 | -0.131 | -3 | 0.783 |
PRKX |
0.722 | 0.058 | -3 | 0.655 |
GSK3A |
0.722 | 0.185 | 4 | 0.464 |
PINK1 |
0.722 | 0.130 | 1 | 0.323 |
LATS1 |
0.721 | 0.025 | -3 | 0.793 |
MSK2 |
0.720 | -0.007 | -3 | 0.726 |
NUAK1 |
0.720 | -0.029 | -3 | 0.742 |
IRE2 |
0.720 | -0.059 | 2 | 0.739 |
BUB1 |
0.720 | 0.113 | -5 | 0.771 |
MASTL |
0.720 | -0.144 | -2 | 0.757 |
RIPK1 |
0.720 | -0.142 | 1 | 0.096 |
PKR |
0.720 | -0.043 | 1 | 0.125 |
AKT1 |
0.720 | 0.042 | -3 | 0.691 |
QSK |
0.720 | -0.017 | 4 | 0.800 |
PKCH |
0.719 | -0.027 | 2 | 0.696 |
TSSK2 |
0.718 | -0.094 | -5 | 0.820 |
HUNK |
0.718 | -0.168 | 2 | 0.727 |
MSK1 |
0.717 | 0.016 | -3 | 0.723 |
PIM2 |
0.717 | 0.023 | -3 | 0.720 |
ATM |
0.717 | -0.083 | 1 | 0.138 |
CHAK1 |
0.716 | -0.103 | 2 | 0.769 |
BMPR1B |
0.716 | -0.065 | 1 | 0.089 |
AURA |
0.715 | 0.024 | -2 | 0.696 |
ALK4 |
0.715 | -0.069 | -2 | 0.742 |
SIK |
0.715 | -0.029 | -3 | 0.720 |
QIK |
0.715 | -0.090 | -3 | 0.788 |
DLK |
0.715 | -0.174 | 1 | 0.120 |
CAMK4 |
0.715 | -0.098 | -3 | 0.767 |
PKCT |
0.715 | -0.011 | 2 | 0.708 |
PAK2 |
0.715 | -0.030 | -2 | 0.814 |
CAMK2A |
0.714 | -0.014 | 2 | 0.704 |
BRSK2 |
0.713 | -0.044 | -3 | 0.771 |
PKACA |
0.713 | 0.038 | -2 | 0.701 |
TGFBR1 |
0.713 | -0.060 | -2 | 0.706 |
DCAMKL1 |
0.713 | -0.022 | -3 | 0.755 |
PAK5 |
0.713 | 0.012 | -2 | 0.704 |
WNK4 |
0.713 | -0.085 | -2 | 0.874 |
YSK4 |
0.713 | -0.124 | 1 | 0.098 |
PKCI |
0.712 | -0.002 | 2 | 0.731 |
MAPKAPK5 |
0.712 | -0.065 | -3 | 0.714 |
ANKRD3 |
0.712 | -0.189 | 1 | 0.124 |
MYLK4 |
0.711 | -0.014 | -2 | 0.812 |
GRK6 |
0.711 | -0.154 | 1 | 0.103 |
MST3 |
0.711 | -0.028 | 2 | 0.804 |
PHKG2 |
0.711 | -0.063 | -3 | 0.752 |
TLK2 |
0.711 | -0.092 | 1 | 0.112 |
AKT3 |
0.710 | 0.049 | -3 | 0.630 |
CAMK2B |
0.710 | -0.065 | 2 | 0.695 |
TTBK2 |
0.710 | -0.189 | 2 | 0.662 |
BRSK1 |
0.709 | -0.037 | -3 | 0.757 |
PKCE |
0.709 | 0.021 | 2 | 0.697 |
LKB1 |
0.709 | 0.050 | -3 | 0.826 |
TAO3 |
0.709 | -0.001 | 1 | 0.143 |
NEK5 |
0.709 | -0.063 | 1 | 0.107 |
IRAK4 |
0.709 | -0.080 | 1 | 0.089 |
PAK4 |
0.708 | 0.015 | -2 | 0.712 |
MEK1 |
0.708 | -0.151 | 2 | 0.774 |
MLK4 |
0.706 | -0.102 | 2 | 0.685 |
MARK3 |
0.706 | -0.043 | 4 | 0.751 |
PKN1 |
0.705 | -0.014 | -3 | 0.706 |
SGK1 |
0.705 | 0.058 | -3 | 0.606 |
PDK1 |
0.705 | -0.018 | 1 | 0.148 |
PLK4 |
0.704 | -0.109 | 2 | 0.583 |
GSK3B |
0.704 | 0.047 | 4 | 0.458 |
MEKK1 |
0.704 | -0.122 | 1 | 0.123 |
ACVR2A |
0.704 | -0.115 | -2 | 0.684 |
CK1E |
0.704 | -0.041 | -3 | 0.519 |
ACVR2B |
0.703 | -0.110 | -2 | 0.696 |
CHK1 |
0.703 | -0.081 | -3 | 0.766 |
FAM20C |
0.703 | -0.036 | 2 | 0.555 |
P70S6K |
0.703 | -0.025 | -3 | 0.683 |
MEK5 |
0.703 | -0.132 | 2 | 0.775 |
MARK2 |
0.703 | -0.063 | 4 | 0.719 |
GRK4 |
0.703 | -0.191 | -2 | 0.723 |
PERK |
0.702 | -0.134 | -2 | 0.735 |
PLK1 |
0.702 | -0.166 | -2 | 0.706 |
CAMK1G |
0.702 | -0.067 | -3 | 0.733 |
MEKK2 |
0.702 | -0.099 | 2 | 0.763 |
SSTK |
0.702 | -0.066 | 4 | 0.795 |
SNRK |
0.702 | -0.139 | 2 | 0.645 |
DRAK1 |
0.701 | -0.135 | 1 | 0.082 |
HGK |
0.701 | -0.019 | 3 | 0.868 |
ZAK |
0.701 | -0.140 | 1 | 0.106 |
KHS1 |
0.701 | 0.022 | 1 | 0.120 |
PBK |
0.701 | 0.001 | 1 | 0.146 |
MAP3K15 |
0.700 | -0.029 | 1 | 0.120 |
TAO2 |
0.700 | -0.028 | 2 | 0.816 |
HRI |
0.700 | -0.157 | -2 | 0.768 |
SMMLCK |
0.700 | -0.026 | -3 | 0.779 |
DCAMKL2 |
0.700 | -0.052 | -3 | 0.765 |
TNIK |
0.700 | 0.005 | 3 | 0.873 |
MEKK6 |
0.700 | -0.062 | 1 | 0.122 |
SBK |
0.699 | 0.092 | -3 | 0.573 |
ALK2 |
0.699 | -0.104 | -2 | 0.707 |
HASPIN |
0.699 | 0.040 | -1 | 0.701 |
MRCKB |
0.699 | 0.024 | -3 | 0.703 |
ROCK2 |
0.699 | 0.030 | -3 | 0.749 |
GCK |
0.698 | -0.020 | 1 | 0.125 |
KHS2 |
0.698 | 0.026 | 1 | 0.132 |
CK1D |
0.698 | -0.022 | -3 | 0.468 |
HPK1 |
0.698 | -0.031 | 1 | 0.125 |
PASK |
0.697 | -0.038 | -3 | 0.816 |
BRAF |
0.697 | -0.142 | -4 | 0.544 |
LOK |
0.697 | -0.025 | -2 | 0.736 |
CK1G1 |
0.697 | -0.068 | -3 | 0.488 |
NEK4 |
0.696 | -0.101 | 1 | 0.098 |
NEK11 |
0.696 | -0.116 | 1 | 0.137 |
NEK1 |
0.696 | -0.050 | 1 | 0.089 |
NEK8 |
0.695 | -0.126 | 2 | 0.788 |
DAPK3 |
0.695 | -0.011 | -3 | 0.762 |
GRK2 |
0.695 | -0.111 | -2 | 0.622 |
MARK1 |
0.694 | -0.094 | 4 | 0.768 |
MRCKA |
0.694 | 0.011 | -3 | 0.710 |
PKG1 |
0.694 | 0.004 | -2 | 0.675 |
MINK |
0.693 | -0.072 | 1 | 0.101 |
LRRK2 |
0.693 | 0.007 | 2 | 0.814 |
BMPR1A |
0.693 | -0.095 | 1 | 0.082 |
MEKK3 |
0.693 | -0.196 | 1 | 0.115 |
CK1A2 |
0.692 | -0.044 | -3 | 0.471 |
GAK |
0.692 | -0.076 | 1 | 0.158 |
CHK2 |
0.691 | -0.011 | -3 | 0.630 |
CAMK1D |
0.691 | -0.041 | -3 | 0.660 |
CAMKK2 |
0.691 | -0.109 | -2 | 0.711 |
PLK3 |
0.690 | -0.165 | 2 | 0.679 |
DAPK1 |
0.690 | -0.017 | -3 | 0.753 |
EEF2K |
0.689 | -0.058 | 3 | 0.828 |
YSK1 |
0.689 | -0.066 | 2 | 0.794 |
NEK3 |
0.689 | -0.070 | 1 | 0.124 |
SLK |
0.688 | -0.031 | -2 | 0.655 |
CAMKK1 |
0.688 | -0.158 | -2 | 0.703 |
TLK1 |
0.688 | -0.194 | -2 | 0.730 |
CAMK1A |
0.687 | -0.017 | -3 | 0.637 |
VRK1 |
0.687 | -0.102 | 2 | 0.801 |
DMPK1 |
0.686 | 0.033 | -3 | 0.723 |
TTBK1 |
0.686 | -0.166 | 2 | 0.578 |
ROCK1 |
0.684 | 0.009 | -3 | 0.717 |
CRIK |
0.684 | 0.021 | -3 | 0.691 |
MST2 |
0.683 | -0.138 | 1 | 0.109 |
MYO3B |
0.682 | -0.009 | 2 | 0.816 |
TAK1 |
0.682 | -0.167 | 1 | 0.104 |
IRAK1 |
0.681 | -0.224 | -1 | 0.724 |
LIMK2_TYR |
0.681 | 0.184 | -3 | 0.835 |
AAK1 |
0.681 | 0.014 | 1 | 0.165 |
GRK3 |
0.680 | -0.112 | -2 | 0.572 |
BIKE |
0.680 | -0.023 | 1 | 0.154 |
TAO1 |
0.679 | -0.036 | 1 | 0.119 |
CK2A2 |
0.679 | -0.093 | 1 | 0.074 |
STK33 |
0.679 | -0.116 | 2 | 0.551 |
MEK2 |
0.678 | -0.156 | 2 | 0.770 |
PDHK3_TYR |
0.677 | 0.131 | 4 | 0.888 |
RIPK2 |
0.677 | -0.192 | 1 | 0.093 |
ASK1 |
0.674 | -0.077 | 1 | 0.120 |
OSR1 |
0.673 | -0.063 | 2 | 0.761 |
MST1 |
0.673 | -0.169 | 1 | 0.099 |
TESK1_TYR |
0.672 | 0.074 | 3 | 0.850 |
PKMYT1_TYR |
0.672 | 0.134 | 3 | 0.809 |
CK2A1 |
0.671 | -0.096 | 1 | 0.067 |
MYO3A |
0.669 | -0.071 | 1 | 0.119 |
MAP2K4_TYR |
0.669 | 0.033 | -1 | 0.823 |
PDHK4_TYR |
0.666 | 0.029 | 2 | 0.808 |
MAP2K7_TYR |
0.665 | -0.029 | 2 | 0.800 |
NEK10_TYR |
0.663 | -0.030 | 1 | 0.122 |
PLK2 |
0.663 | -0.116 | -3 | 0.719 |
LIMK1_TYR |
0.662 | 0.021 | 2 | 0.819 |
MAP2K6_TYR |
0.661 | -0.013 | -1 | 0.819 |
JAK1 |
0.661 | -0.016 | 1 | 0.121 |
PINK1_TYR |
0.660 | -0.132 | 1 | 0.160 |
JAK2 |
0.660 | -0.060 | 1 | 0.146 |
CK1A |
0.660 | -0.064 | -3 | 0.380 |
RET |
0.660 | -0.077 | 1 | 0.135 |
TTK |
0.660 | -0.118 | -2 | 0.721 |
BMPR2_TYR |
0.659 | -0.030 | -1 | 0.809 |
TYK2 |
0.658 | -0.127 | 1 | 0.124 |
TNNI3K_TYR |
0.657 | 0.003 | 1 | 0.151 |
MST1R |
0.657 | -0.055 | 3 | 0.773 |
PDHK1_TYR |
0.657 | -0.087 | -1 | 0.821 |
TNK1 |
0.657 | 0.009 | 3 | 0.744 |
CSF1R |
0.656 | -0.046 | 3 | 0.748 |
ROS1 |
0.655 | -0.075 | 3 | 0.734 |
YANK3 |
0.654 | -0.065 | 2 | 0.338 |
ABL2 |
0.654 | -0.050 | -1 | 0.763 |
ALPHAK3 |
0.654 | -0.117 | -1 | 0.707 |
TYRO3 |
0.653 | -0.079 | 3 | 0.765 |
ABL1 |
0.652 | -0.061 | -1 | 0.758 |
TNK2 |
0.649 | -0.058 | 3 | 0.694 |
STLK3 |
0.649 | -0.163 | 1 | 0.094 |
TXK |
0.648 | -0.061 | 1 | 0.085 |
EPHB4 |
0.648 | -0.092 | -1 | 0.765 |
EPHA6 |
0.647 | -0.099 | -1 | 0.784 |
LCK |
0.647 | -0.062 | -1 | 0.813 |
JAK3 |
0.646 | -0.119 | 1 | 0.128 |
HCK |
0.645 | -0.100 | -1 | 0.814 |
YES1 |
0.645 | -0.095 | -1 | 0.823 |
DDR1 |
0.644 | -0.126 | 4 | 0.817 |
FGR |
0.644 | -0.138 | 1 | 0.093 |
BLK |
0.642 | -0.068 | -1 | 0.811 |
WEE1_TYR |
0.642 | -0.055 | -1 | 0.713 |
KDR |
0.642 | -0.080 | 3 | 0.693 |
FGFR1 |
0.641 | -0.052 | 3 | 0.698 |
FGFR2 |
0.640 | -0.073 | 3 | 0.716 |
ITK |
0.639 | -0.115 | -1 | 0.781 |
PDGFRB |
0.639 | -0.166 | 3 | 0.759 |
TEK |
0.639 | -0.035 | 3 | 0.667 |
KIT |
0.638 | -0.130 | 3 | 0.738 |
PDGFRA |
0.638 | -0.156 | 3 | 0.759 |
FER |
0.638 | -0.177 | 1 | 0.107 |
MERTK |
0.637 | -0.103 | 3 | 0.714 |
CK1G3 |
0.636 | -0.071 | -3 | 0.334 |
FLT3 |
0.636 | -0.173 | 3 | 0.763 |
AXL |
0.636 | -0.133 | 3 | 0.712 |
SRMS |
0.636 | -0.151 | 1 | 0.082 |
BMX |
0.635 | -0.089 | -1 | 0.717 |
EPHB1 |
0.634 | -0.156 | 1 | 0.089 |
INSRR |
0.634 | -0.171 | 3 | 0.681 |
DDR2 |
0.634 | -0.028 | 3 | 0.653 |
MET |
0.633 | -0.115 | 3 | 0.737 |
BTK |
0.633 | -0.155 | -1 | 0.767 |
ALK |
0.633 | -0.121 | 3 | 0.659 |
FRK |
0.632 | -0.115 | -1 | 0.813 |
EPHA4 |
0.632 | -0.116 | 2 | 0.672 |
FYN |
0.631 | -0.083 | -1 | 0.797 |
PTK6 |
0.631 | -0.149 | -1 | 0.700 |
EPHB3 |
0.631 | -0.159 | -1 | 0.750 |
TEC |
0.630 | -0.131 | -1 | 0.731 |
EPHA1 |
0.629 | -0.118 | 3 | 0.716 |
LTK |
0.628 | -0.139 | 3 | 0.675 |
EPHB2 |
0.628 | -0.161 | -1 | 0.740 |
FGFR3 |
0.626 | -0.098 | 3 | 0.681 |
PTK2B |
0.625 | -0.095 | -1 | 0.749 |
MUSK |
0.625 | -0.101 | 1 | 0.070 |
ERBB2 |
0.624 | -0.173 | 1 | 0.107 |
EPHA7 |
0.624 | -0.122 | 2 | 0.681 |
NTRK3 |
0.623 | -0.142 | -1 | 0.696 |
EGFR |
0.623 | -0.115 | 1 | 0.086 |
FLT1 |
0.623 | -0.170 | -1 | 0.740 |
LYN |
0.623 | -0.140 | 3 | 0.656 |
NTRK1 |
0.623 | -0.202 | -1 | 0.741 |
NTRK2 |
0.623 | -0.193 | 3 | 0.690 |
SRC |
0.622 | -0.119 | -1 | 0.786 |
INSR |
0.621 | -0.164 | 3 | 0.668 |
MATK |
0.619 | -0.116 | -1 | 0.665 |
FLT4 |
0.619 | -0.183 | 3 | 0.673 |
CSK |
0.617 | -0.148 | 2 | 0.690 |
EPHA3 |
0.617 | -0.157 | 2 | 0.653 |
YANK2 |
0.617 | -0.091 | 2 | 0.348 |
FGFR4 |
0.614 | -0.126 | -1 | 0.691 |
EPHA8 |
0.613 | -0.141 | -1 | 0.734 |
SYK |
0.613 | -0.107 | -1 | 0.706 |
ZAP70 |
0.610 | -0.049 | -1 | 0.641 |
PTK2 |
0.610 | -0.096 | -1 | 0.719 |
EPHA5 |
0.610 | -0.164 | 2 | 0.650 |
CK1G2 |
0.608 | -0.082 | -3 | 0.417 |
ERBB4 |
0.607 | -0.108 | 1 | 0.085 |
EPHA2 |
0.603 | -0.146 | -1 | 0.699 |
IGF1R |
0.602 | -0.169 | 3 | 0.592 |
FES |
0.594 | -0.147 | -1 | 0.676 |