Motif 232 (n=196)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NEL2 | SOWAHB | S271 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A6NF01 | POM121B | S210 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NHT5 | HMX3 | S144 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| A8CG34 | POM121C | S603 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| O00411 | POLRMT | S666 | ochoa | DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). {ECO:0000269|PubMed:18685103, ECO:0000269|PubMed:21278163, ECO:0000269|PubMed:29149603, ECO:0000269|PubMed:33602924}. |
| O14497 | ARID1A | S715 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14578 | CIT | S1322 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O14686 | KMT2D | S2342 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14908 | GIPC1 | S68 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
| O14976 | GAK | S770 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15018 | PDZD2 | S1280 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15085 | ARHGEF11 | S150 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15394 | NCAM2 | S786 | ochoa | Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) | May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. |
| O15417 | TNRC18 | S1127 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43312 | MTSS1 | S721 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43683 | BUB1 | S375 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60239 | SH3BP5 | S351 | ochoa | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000269|PubMed:10339589, ECO:0000269|PubMed:26506309, ECO:0000269|PubMed:30217979, ECO:0000269|PubMed:9571151}. |
| O60281 | ZNF292 | S1462 | ochoa | Zinc finger protein 292 | May be involved in transcriptional regulation. |
| O60496 | DOK2 | S282 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| O60610 | DIAPH1 | S22 | ochoa | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854, PubMed:21834987). It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity (PubMed:20937854, PubMed:21834987). In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854, PubMed:21834987). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). {ECO:0000250|UniProtKB:O08808, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24781755, ECO:0000269|PubMed:26912466}. |
| O60885 | BRD4 | S1083 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75362 | ZNF217 | S980 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75815 | BCAR3 | S32 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75955 | FLOT1 | S19 | ochoa | Flotillin-1 | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| O94855 | SEC24D | S22 | ochoa | Protein transport protein Sec24D (SEC24-related protein D) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| O94989 | ARHGEF15 | S90 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
| O95153 | TSPOAP1 | S1091 | ochoa | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) | Required for synaptic transmission regulation (PubMed:33539324). It probably controls the recruitement of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release. {ECO:0000269|PubMed:33539324}. |
| O95359 | TACC2 | S1796 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95644 | NFATC1 | S887 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| P0CG12 | DERPC | S423 | ochoa | Decreased expression in renal and prostate cancer protein | Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}. |
| P10275 | AR | S96 | ochoa|psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P12270 | TPR | S1752 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12980 | LYL1 | S52 | ochoa | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
| P15923 | TCF3 | S245 | ochoa|psp | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P15976 | GATA1 | S187 | psp | Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein) | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:35030251}. |
| P17483 | HOXB4 | S116 | ochoa | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P26045 | PTPN3 | S372 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P27987 | ITPKB | S49 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P28290 | ITPRID2 | S759 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P28749 | RBL1 | S988 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P29590 | PML | S518 | ochoa|psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P30414 | NKTR | S1146 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P33076 | CIITA | S293 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P35612 | ADD2 | S613 | ochoa|psp | Beta-adducin (Erythrocyte adducin subunit beta) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}. |
| P39880 | CUX1 | S1237 | ochoa|psp | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P40818 | USP8 | S392 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P41161 | ETV5 | S248 | ochoa | ETS translocation variant 5 (Ets-related protein ERM) | Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}. |
| P41212 | ETV6 | S271 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P43354 | NR4A2 | S181 | ochoa|psp | Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250|UniProtKB:Q06219, ECO:0000269|PubMed:15716272, ECO:0000269|PubMed:17184956}. |
| P46060 | RANGAP1 | S442 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
| P50406 | HTR6 | S350 | psp | 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6) | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611, ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:36989299, ECO:0000269|PubMed:37327704, ECO:0000269|PubMed:8522988}. |
| P50549 | ETV1 | S216 | ochoa|psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
| P51531 | SMARCA2 | S329 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51825 | AFF1 | S212 | ochoa|psp | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P53804 | TTC3 | S1819 | ochoa | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}. |
| P54253 | ATXN1 | S253 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
| P54259 | ATN1 | S677 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55201 | BRPF1 | S926 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P79522 | PRR3 | S33 | ochoa | Proline-rich protein 3 (MHC class I region proline-rich protein CAT56) | None |
| P98174 | FGD1 | S149 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q00613 | HSF1 | S275 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q02779 | MAP3K10 | S502 | ochoa | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Q04725 | TLE2 | S307 | ochoa | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. |
| Q05516 | ZBTB16 | S197 | psp | Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) | Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). {ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:24359566}. |
| Q12948 | FOXC1 | S272 | ochoa|psp | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q12968 | NFATC3 | S117 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q12988 | HSPB3 | S53 | ochoa | Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3) | Inhibitor of actin polymerization. |
| Q13094 | LCP2 | S344 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13469 | NFATC2 | S53 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13469 | NFATC2 | S73 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13627 | DYRK1A | S555 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| Q13950 | RUNX2 | S294 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14966 | ZNF638 | S1119 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q14999 | CUL7 | S339 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q14CZ8 | HEPACAM | S377 | ochoa | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205). {ECO:0000269|PubMed:15885354, ECO:0000269|PubMed:15917256, ECO:0000269|PubMed:22405205}. |
| Q15596 | NCOA2 | S499 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15788 | NCOA1 | S1006 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q16584 | MAP3K11 | S693 | ochoa | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16665 | HIF1A | S451 | ochoa|psp | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269|PubMed:32697943}. |
| Q16666 | IFI16 | S166 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2M3G4 | SHROOM1 | S401 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q3KP66 | INAVA | S313 | ochoa | Innate immunity activator protein | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
| Q49AM3 | TTC31 | S464 | ochoa | Tetratricopeptide repeat protein 31 (TPR repeat protein 31) | None |
| Q52LW3 | ARHGAP29 | S1029 | ochoa | Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}. |
| Q58EX7 | PLEKHG4 | S64 | ochoa | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) | Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. |
| Q5SV97 | PERM1 | S172 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5SW79 | CEP170 | S1529 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T0B9 | ZNF362 | S160 | ochoa | Zinc finger protein 362 | May be involved in transcriptional regulation. |
| Q5T5P2 | KIAA1217 | S326 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5TGY3 | AHDC1 | S957 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TGY3 | AHDC1 | S1399 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VUA4 | ZNF318 | S709 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VZK9 | CARMIL1 | S1288 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63HR2 | TNS2 | S991 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q674X7 | KAZN | S352 | ochoa | Kazrin | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Q68CP9 | ARID2 | S689 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q68CZ2 | TNS3 | S866 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q69YQ0 | SPECC1L | S881 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6AI12 | ANKRD40 | S160 | ochoa | Ankyrin repeat domain-containing protein 40 | None |
| Q6IQ19 | CCSAP | S145 | ochoa | Centriole, cilia and spindle-associated protein | Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}. |
| Q6NV74 | CRACDL | S356 | ochoa | CRACD-like protein | None |
| Q6P0Q8 | MAST2 | S66 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6UB99 | ANKRD11 | S1891 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UUV9 | CRTC1 | S424 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6WKZ4 | RAB11FIP1 | S545 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q70E73 | RAPH1 | S1098 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q765P7 | MTSS2 | S441 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q76L83 | ASXL2 | S1300 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7RTP6 | MICAL3 | S1384 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z434 | MAVS | S165 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z6E9 | RBBP6 | S360 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6J0 | SH3RF1 | S551 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q86US8 | SMG6 | S424 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UU0 | BCL9L | S1017 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86YW5 | TREML1 | S252 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IXT5 | RBM12B | S874 | ochoa | RNA-binding protein 12B (RNA-binding motif protein 12B) | None |
| Q8IY33 | MICALL2 | S494 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IYI8 | ZNF440 | S513 | ochoa | Zinc finger protein 440 | May be involved in transcriptional regulation. |
| Q8IYJ0 | PIANP | S245 | ochoa | PILR alpha-associated neural protein (PILR-associating neural protein) (Paired immunoglobin-like type 2 receptor-associating neural protein) | Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. {ECO:0000269|PubMed:21241660}. |
| Q8IYJ3 | SYTL1 | S392 | ochoa | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Q8IZD4 | DCP1B | S566 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8IZW8 | TNS4 | S82 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N0Z2 | ABRA | S81 | ochoa | Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) | Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000250|UniProtKB:Q8BUZ1}. |
| Q8N3J3 | HROB | S351 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N8K9 | KIAA1958 | S291 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NBZ0 | INO80E | S154 | ochoa|psp | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q8NHG8 | ZNRF2 | S151 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TC05 | MDM1 | S631 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8TC76 | FAM110B | S95 | ochoa | Protein FAM110B | May be involved in tumor progression. |
| Q8TE67 | EPS8L3 | S205 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8TE67 | EPS8L3 | S518 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8TEK3 | DOT1L | S471 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WUF5 | PPP1R13L | S183 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q92570 | NR4A3 | S393 | ochoa | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
| Q92574 | TSC1 | S361 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92738 | USP6NL | S680 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92793 | CREBBP | S2076 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92835 | INPP5D | S960 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q96BA8 | CREB3L1 | S221 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1] | [Cyclic AMP-responsive element-binding protein 3-like protein 1]: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane (PubMed:12054625, PubMed:16417584, PubMed:25310401). In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition (PubMed:12054625, PubMed:21767813, PubMed:25310401). {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:16417584, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401). {ECO:0000250|UniProtKB:Q9Z125, ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:25310401}.; FUNCTION: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). {ECO:0000269|PubMed:21767813}. |
| Q96D71 | REPS1 | S617 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96EB6 | SIRT1 | S27 | ochoa|psp | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96EP0 | RNF31 | S437 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96FJ0 | STAMBPL1 | S242 | ochoa | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}. |
| Q96HA1 | POM121 | S626 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96HR8 | NAF1 | S50 | ochoa | H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1) | RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269|PubMed:16618814}. |
| Q96L14 | CEP170P1 | S238 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
| Q96MG2 | JSRP1 | S167 | ochoa | Junctional sarcoplasmic reticulum protein 1 (Junctional-face membrane protein of 45 kDa homolog) (JP-45) | Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}. |
| Q96P48 | ARAP1 | S91 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250|UniProtKB:Q4LDD4, ECO:0000269|PubMed:11804590, ECO:0000269|PubMed:18764928, ECO:0000269|PubMed:18939958, ECO:0000269|PubMed:19666464, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:22573888, ECO:0000269|PubMed:38682696}. |
| Q96PE2 | ARHGEF17 | S348 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96RT7 | TUBGCP6 | S1296 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q99081 | TCF12 | S305 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99607 | ELF4 | S641 | ochoa|psp | ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor) | Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) (PubMed:34326534, PubMed:35266071). {ECO:0000250, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:14625302, ECO:0000269|PubMed:14976184, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:34326534, ECO:0000269|PubMed:35266071, ECO:0000269|PubMed:8895518, ECO:0000269|PubMed:9524226}. |
| Q9BQ89 | FAM110A | S78 | ochoa | Protein FAM110A | None |
| Q9BXA9 | SALL3 | S940 | ochoa | Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) | Probable transcription factor. |
| Q9BY89 | KIAA1671 | S1154 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S1253 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C0B5 | ZDHHC5 | S593 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S1439 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0K0 | BCL11B | S678 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H3T3 | SEMA6B | S822 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H4M7 | PLEKHA4 | S329 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H706 | GAREM1 | S546 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
| Q9H7P9 | PLEKHG2 | S1049 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H7P9 | PLEKHG2 | S1227 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H8N7 | ZNF395 | S468 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9HCD6 | TANC2 | S1619 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCE9 | ANO8 | S641 | ochoa | Anoctamin-8 (Transmembrane protein 16H) | Does not exhibit calcium-activated chloride channel (CaCC) activity. |
| Q9NPI6 | DCP1A | S373 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NR48 | ASH1L | S570 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRA8 | EIF4ENIF1 | S513 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NX65 | ZSCAN32 | S30 | ochoa | Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434) | May be involved in transcriptional regulation. |
| Q9NYB9 | ABI2 | S196 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYJ8 | TAB2 | S450 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
| Q9NZM4 | BICRA | S1413 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
| Q9P1Y6 | PHRF1 | S568 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P1Y6 | PHRF1 | S1229 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P206 | NHSL3 | Y982 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UGP4 | LIMD1 | S384 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHY1 | NRBP1 | S422 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UK80 | USP21 | S93 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
| Q9UKL3 | CASP8AP2 | S875 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UL54 | TAOK2 | S777 | ochoa | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11279118, ECO:0000269|PubMed:12639963, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:17158878, ECO:0000269|PubMed:17396146}. |
| Q9ULD4 | BRPF3 | S852 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9UM54 | MYO6 | S1155 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9UM82 | SPATA2 | S308 | ochoa | Spermatogenesis-associated protein 2 | Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). {ECO:0000250|UniProtKB:Q8K004, ECO:0000269|PubMed:27307491, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27545878, ECO:0000269|PubMed:27591049}. |
| Q9UN79 | SOX13 | S335 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPW6 | SATB2 | S39 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UQ35 | SRRM2 | S1320 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQQ2 | SH2B3 | S511 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y2F5 | ICE1 | S1712 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2K7 | KDM2A | S731 | ochoa | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}. |
| Q9Y2X9 | ZNF281 | S255 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y4Z2 | NEUROG3 | S174 | psp | Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5) | Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}. |
| Q9Y6Y8 | SEC23IP | S258 | ochoa | SEC23-interacting protein (p125) | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000269|PubMed:10400679, ECO:0000269|PubMed:15623529, ECO:0000269|PubMed:22922100}. |
| O75925 | PIAS1 | S90 | iPTMNet | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250|UniProtKB:O88907, ECO:0000269|PubMed:11583632, ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:14500712, ECO:0000269|PubMed:15133049, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269|PubMed:29262325}. |
| P07949 | RET | S1065 | Sugiyama | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000008 | 5.074 |
| R-HSA-4839726 | Chromatin organization | 0.000022 | 4.648 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.000035 | 4.461 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.000074 | 4.132 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.000074 | 4.132 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.000211 | 3.676 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.000368 | 3.434 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.000486 | 3.313 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000450 | 3.347 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.000472 | 3.326 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.000625 | 3.204 |
| R-HSA-73887 | Death Receptor Signaling | 0.000637 | 3.196 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.001139 | 2.943 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.001271 | 2.896 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.001988 | 2.702 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.001931 | 2.714 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.002181 | 2.661 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.002204 | 2.657 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.002181 | 2.661 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.002674 | 2.573 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.002958 | 2.529 |
| R-HSA-9707616 | Heme signaling | 0.002833 | 2.548 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.003113 | 2.507 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.003475 | 2.459 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.004199 | 2.377 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.004199 | 2.377 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.004050 | 2.393 |
| R-HSA-5688426 | Deubiquitination | 0.004649 | 2.333 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.004464 | 2.350 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.004971 | 2.304 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.005219 | 2.282 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.005537 | 2.257 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.006575 | 2.182 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.006673 | 2.176 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.006673 | 2.176 |
| R-HSA-74160 | Gene expression (Transcription) | 0.006866 | 2.163 |
| R-HSA-212436 | Generic Transcription Pathway | 0.007767 | 2.110 |
| R-HSA-8849473 | PTK6 Expression | 0.008345 | 2.079 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.008462 | 2.073 |
| R-HSA-9830364 | Formation of the nephric duct | 0.008935 | 2.049 |
| R-HSA-3371556 | Cellular response to heat stress | 0.010752 | 1.969 |
| R-HSA-75893 | TNF signaling | 0.011671 | 1.933 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.015790 | 1.802 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.013324 | 1.875 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.014325 | 1.844 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.014325 | 1.844 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.016451 | 1.784 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.016451 | 1.784 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.017577 | 1.755 |
| R-HSA-1538133 | G0 and Early G1 | 0.015367 | 1.813 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.017577 | 1.755 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.016451 | 1.784 |
| R-HSA-3214847 | HATs acetylate histones | 0.017674 | 1.753 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.016451 | 1.784 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.014272 | 1.846 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.015378 | 1.813 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.013324 | 1.875 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.014865 | 1.828 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.017674 | 1.753 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.017967 | 1.746 |
| R-HSA-4641265 | Repression of WNT target genes | 0.020263 | 1.693 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.019955 | 1.700 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.020263 | 1.693 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.019584 | 1.708 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.018816 | 1.725 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.018745 | 1.727 |
| R-HSA-9830369 | Kidney development | 0.019651 | 1.707 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.018745 | 1.727 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.018745 | 1.727 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.020508 | 1.688 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.021077 | 1.676 |
| R-HSA-8853659 | RET signaling | 0.021207 | 1.674 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.022675 | 1.644 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.025216 | 1.598 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.025200 | 1.599 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.021624 | 1.665 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.021624 | 1.665 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.025200 | 1.599 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.022501 | 1.648 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.025216 | 1.598 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.025200 | 1.599 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.026637 | 1.575 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.026637 | 1.575 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.027727 | 1.557 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.027832 | 1.555 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.027832 | 1.555 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.028100 | 1.551 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.028100 | 1.551 |
| R-HSA-162582 | Signal Transduction | 0.028911 | 1.539 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.035786 | 1.446 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.033411 | 1.476 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.036040 | 1.443 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.033411 | 1.476 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.034369 | 1.464 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.031461 | 1.502 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.037753 | 1.423 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.037753 | 1.423 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.037753 | 1.423 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 0.039804 | 1.400 |
| R-HSA-163282 | Mitochondrial transcription initiation | 0.039804 | 1.400 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.042959 | 1.367 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.042959 | 1.367 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.042959 | 1.367 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.043134 | 1.365 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.045728 | 1.340 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.048878 | 1.311 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.058736 | 1.231 |
| R-HSA-75944 | Transcription from mitochondrial promoters | 0.052718 | 1.278 |
| R-HSA-191859 | snRNP Assembly | 0.063641 | 1.196 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.063641 | 1.196 |
| R-HSA-9909396 | Circadian clock | 0.052144 | 1.283 |
| R-HSA-186712 | Regulation of beta-cell development | 0.063641 | 1.196 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.059433 | 1.226 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.063641 | 1.196 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.053433 | 1.272 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.059234 | 1.227 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.058736 | 1.231 |
| R-HSA-70171 | Glycolysis | 0.065329 | 1.185 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.065459 | 1.184 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.065459 | 1.184 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.065535 | 1.184 |
| R-HSA-9839394 | TGFBR3 expression | 0.066749 | 1.176 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.068197 | 1.166 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.068197 | 1.166 |
| R-HSA-195721 | Signaling by WNT | 0.069429 | 1.158 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.070514 | 1.152 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.070514 | 1.152 |
| R-HSA-525793 | Myogenesis | 0.070514 | 1.152 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.070529 | 1.152 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.078030 | 1.108 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.090432 | 1.044 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.090432 | 1.044 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.077737 | 1.109 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.090432 | 1.044 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.078030 | 1.108 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.086045 | 1.065 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.078030 | 1.108 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.090303 | 1.044 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.090432 | 1.044 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.095735 | 1.019 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.090430 | 1.044 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.072896 | 1.137 |
| R-HSA-8848021 | Signaling by PTK6 | 0.072896 | 1.137 |
| R-HSA-877300 | Interferon gamma signaling | 0.094281 | 1.026 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.074346 | 1.129 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.072896 | 1.137 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.093070 | 1.031 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.091728 | 1.037 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.098435 | 1.007 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.098625 | 1.006 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.098625 | 1.006 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.099467 | 1.002 |
| R-HSA-913531 | Interferon Signaling | 0.100359 | 0.998 |
| R-HSA-210746 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | 0.114741 | 0.940 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.126651 | 0.897 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.149996 | 0.824 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.172720 | 0.763 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.183854 | 0.736 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.237327 | 0.625 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.247595 | 0.606 |
| R-HSA-3371568 | Attenuation phase | 0.133806 | 0.874 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.138384 | 0.859 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.296909 | 0.527 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.190619 | 0.720 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.136131 | 0.866 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.136131 | 0.866 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.234992 | 0.629 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.124047 | 0.906 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.205677 | 0.687 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.191397 | 0.718 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.120294 | 0.920 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.190619 | 0.720 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.247595 | 0.606 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.194839 | 0.710 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.284864 | 0.545 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.247595 | 0.606 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.126651 | 0.897 |
| R-HSA-9843745 | Adipogenesis | 0.140253 | 0.853 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.138403 | 0.859 |
| R-HSA-190873 | Gap junction degradation | 0.149996 | 0.824 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.161435 | 0.792 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.183854 | 0.736 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.226919 | 0.644 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.226919 | 0.644 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.267721 | 0.572 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.267721 | 0.572 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.149996 | 0.824 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.161435 | 0.792 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.216369 | 0.665 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.194839 | 0.710 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.114741 | 0.940 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.183854 | 0.736 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.205677 | 0.687 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.296909 | 0.527 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.296909 | 0.527 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.106714 | 0.972 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.185789 | 0.731 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.276586 | 0.558 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.284864 | 0.545 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.114741 | 0.940 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.267721 | 0.572 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.287310 | 0.542 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.184477 | 0.734 |
| R-HSA-202403 | TCR signaling | 0.229714 | 0.639 |
| R-HSA-389542 | NADPH regeneration | 0.114741 | 0.940 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.126651 | 0.897 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.126651 | 0.897 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.138403 | 0.859 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.149996 | 0.824 |
| R-HSA-877312 | Regulation of IFNG signaling | 0.194839 | 0.710 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.226919 | 0.644 |
| R-HSA-9945266 | Differentiation of T cells | 0.237327 | 0.625 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.237327 | 0.625 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.172720 | 0.763 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.226919 | 0.644 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.237327 | 0.625 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.267721 | 0.572 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.277582 | 0.557 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.306378 | 0.514 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.130038 | 0.886 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.121281 | 0.916 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.226169 | 0.646 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.114741 | 0.940 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.247595 | 0.606 |
| R-HSA-68886 | M Phase | 0.305932 | 0.514 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.161749 | 0.791 |
| R-HSA-390666 | Serotonin receptors | 0.161435 | 0.792 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.226919 | 0.644 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.237327 | 0.625 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.247595 | 0.606 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.257726 | 0.589 |
| R-HSA-8875878 | MET promotes cell motility | 0.124759 | 0.904 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.155134 | 0.809 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.205677 | 0.687 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.306378 | 0.514 |
| R-HSA-4086398 | Ca2+ pathway | 0.299802 | 0.523 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.161435 | 0.792 |
| R-HSA-210990 | PECAM1 interactions | 0.172720 | 0.763 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.120294 | 0.920 |
| R-HSA-8854214 | TBC/RABGAPs | 0.152315 | 0.817 |
| R-HSA-597592 | Post-translational protein modification | 0.199961 | 0.699 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.289847 | 0.538 |
| R-HSA-9834899 | Specification of the neural plate border | 0.277582 | 0.557 |
| R-HSA-418990 | Adherens junctions interactions | 0.106400 | 0.973 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.216369 | 0.665 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.267721 | 0.572 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.267721 | 0.572 |
| R-HSA-196108 | Pregnenolone biosynthesis | 0.287310 | 0.542 |
| R-HSA-421270 | Cell-cell junction organization | 0.163868 | 0.786 |
| R-HSA-1266738 | Developmental Biology | 0.271676 | 0.566 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.296909 | 0.527 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.117489 | 0.930 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.274341 | 0.562 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.296909 | 0.527 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.119095 | 0.924 |
| R-HSA-211976 | Endogenous sterols | 0.239968 | 0.620 |
| R-HSA-446728 | Cell junction organization | 0.218817 | 0.660 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.121281 | 0.916 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.121281 | 0.916 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.176089 | 0.754 |
| R-HSA-1280218 | Adaptive Immune System | 0.199061 | 0.701 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.260356 | 0.584 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.277582 | 0.557 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.205677 | 0.687 |
| R-HSA-1500931 | Cell-Cell communication | 0.304585 | 0.516 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.234992 | 0.629 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.287310 | 0.542 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.306378 | 0.514 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.294827 | 0.530 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.168753 | 0.773 |
| R-HSA-70326 | Glucose metabolism | 0.103689 | 0.984 |
| R-HSA-210993 | Tie2 Signaling | 0.267721 | 0.572 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.220104 | 0.657 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.103925 | 0.983 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.244949 | 0.611 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.284864 | 0.545 |
| R-HSA-6806834 | Signaling by MET | 0.118159 | 0.928 |
| R-HSA-68875 | Mitotic Prophase | 0.272940 | 0.564 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.222623 | 0.652 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.222623 | 0.652 |
| R-HSA-201556 | Signaling by ALK | 0.129264 | 0.889 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.127030 | 0.896 |
| R-HSA-9679506 | SARS-CoV Infections | 0.255948 | 0.592 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.205731 | 0.687 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.173202 | 0.761 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.269896 | 0.569 |
| R-HSA-162587 | HIV Life Cycle | 0.214130 | 0.669 |
| R-HSA-211000 | Gene Silencing by RNA | 0.219113 | 0.659 |
| R-HSA-5689603 | UCH proteinases | 0.314689 | 0.502 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.315721 | 0.501 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.315721 | 0.501 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.315721 | 0.501 |
| R-HSA-68877 | Mitotic Prometaphase | 0.323480 | 0.490 |
| R-HSA-200425 | Carnitine shuttle | 0.324939 | 0.488 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.324939 | 0.488 |
| R-HSA-9609690 | HCMV Early Events | 0.332618 | 0.478 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.334032 | 0.476 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.334032 | 0.476 |
| R-HSA-429947 | Deadenylation of mRNA | 0.334032 | 0.476 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.334032 | 0.476 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.334426 | 0.476 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.337919 | 0.471 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.343004 | 0.465 |
| R-HSA-3214842 | HDMs demethylate histones | 0.343004 | 0.465 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.344822 | 0.462 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.351856 | 0.454 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.351856 | 0.454 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.351856 | 0.454 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.351856 | 0.454 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.353727 | 0.451 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.353997 | 0.451 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.358859 | 0.445 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.360589 | 0.443 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.360589 | 0.443 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.368543 | 0.434 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.383000 | 0.417 |
| R-HSA-2424491 | DAP12 signaling | 0.386091 | 0.413 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.386091 | 0.413 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.386091 | 0.413 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.386091 | 0.413 |
| R-HSA-202424 | Downstream TCR signaling | 0.387736 | 0.411 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.388592 | 0.411 |
| R-HSA-9758941 | Gastrulation | 0.393907 | 0.405 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.394364 | 0.404 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.394364 | 0.404 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.394364 | 0.404 |
| R-HSA-182971 | EGFR downregulation | 0.394364 | 0.404 |
| R-HSA-68882 | Mitotic Anaphase | 0.396670 | 0.402 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.397236 | 0.401 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.399707 | 0.398 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.401962 | 0.396 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.410580 | 0.387 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.410580 | 0.387 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.410580 | 0.387 |
| R-HSA-1989781 | PPARA activates gene expression | 0.415566 | 0.381 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.415566 | 0.381 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.416031 | 0.381 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.418525 | 0.378 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.418525 | 0.378 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.418525 | 0.378 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.422733 | 0.374 |
| R-HSA-9610379 | HCMV Late Events | 0.422733 | 0.374 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.426305 | 0.370 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.426364 | 0.370 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.426364 | 0.370 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.426364 | 0.370 |
| R-HSA-5673000 | RAF activation | 0.426364 | 0.370 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.426364 | 0.370 |
| R-HSA-162906 | HIV Infection | 0.429911 | 0.367 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.429933 | 0.367 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.434097 | 0.362 |
| R-HSA-2262752 | Cellular responses to stress | 0.436737 | 0.360 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.439104 | 0.357 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.439104 | 0.357 |
| R-HSA-3371511 | HSF1 activation | 0.441726 | 0.355 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.441726 | 0.355 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.441726 | 0.355 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.441726 | 0.355 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.447571 | 0.349 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.449254 | 0.348 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.449254 | 0.348 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.449254 | 0.348 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.452709 | 0.344 |
| R-HSA-1483255 | PI Metabolism | 0.452709 | 0.344 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.456680 | 0.340 |
| R-HSA-5619102 | SLC transporter disorders | 0.458088 | 0.339 |
| R-HSA-8939211 | ESR-mediated signaling | 0.459712 | 0.338 |
| R-HSA-9833110 | RSV-host interactions | 0.466125 | 0.331 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.466833 | 0.331 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.470554 | 0.327 |
| R-HSA-202433 | Generation of second messenger molecules | 0.471234 | 0.327 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.471234 | 0.327 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.471234 | 0.327 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.471234 | 0.327 |
| R-HSA-9646399 | Aggrephagy | 0.471234 | 0.327 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.471234 | 0.327 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.471234 | 0.327 |
| R-HSA-72306 | tRNA processing | 0.471977 | 0.326 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.478365 | 0.320 |
| R-HSA-9694548 | Maturation of spike protein | 0.478365 | 0.320 |
| R-HSA-9607240 | FLT3 Signaling | 0.478365 | 0.320 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.485400 | 0.314 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.485400 | 0.314 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.485400 | 0.314 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.489110 | 0.311 |
| R-HSA-165159 | MTOR signalling | 0.492341 | 0.308 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.492341 | 0.308 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.492365 | 0.308 |
| R-HSA-9609646 | HCMV Infection | 0.497627 | 0.303 |
| R-HSA-8957322 | Metabolism of steroids | 0.498738 | 0.302 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.499189 | 0.302 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.500930 | 0.300 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.500930 | 0.300 |
| R-HSA-168255 | Influenza Infection | 0.502622 | 0.299 |
| R-HSA-2172127 | DAP12 interactions | 0.505944 | 0.296 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.505944 | 0.296 |
| R-HSA-69236 | G1 Phase | 0.505944 | 0.296 |
| R-HSA-190828 | Gap junction trafficking | 0.505944 | 0.296 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.505944 | 0.296 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.505944 | 0.296 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.514747 | 0.288 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.519185 | 0.285 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.519185 | 0.285 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.519185 | 0.285 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.519185 | 0.285 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.525672 | 0.279 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.525672 | 0.279 |
| R-HSA-1640170 | Cell Cycle | 0.528145 | 0.277 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.530171 | 0.276 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.538386 | 0.269 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.554295 | 0.256 |
| R-HSA-199991 | Membrane Trafficking | 0.554754 | 0.256 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.556824 | 0.254 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.556824 | 0.254 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.556824 | 0.254 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.562805 | 0.250 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.562805 | 0.250 |
| R-HSA-114608 | Platelet degranulation | 0.573724 | 0.241 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.574528 | 0.241 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.574528 | 0.241 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.577536 | 0.238 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.577712 | 0.238 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.580272 | 0.236 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.580272 | 0.236 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.580272 | 0.236 |
| R-HSA-177929 | Signaling by EGFR | 0.580272 | 0.236 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.591529 | 0.228 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.599882 | 0.222 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.602485 | 0.220 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.602485 | 0.220 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.602485 | 0.220 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.602485 | 0.220 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.602485 | 0.220 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.602485 | 0.220 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.607853 | 0.216 |
| R-HSA-450294 | MAP kinase activation | 0.607853 | 0.216 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.613149 | 0.212 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.613149 | 0.212 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.614282 | 0.212 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.617819 | 0.209 |
| R-HSA-373755 | Semaphorin interactions | 0.618373 | 0.209 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.618679 | 0.209 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.623528 | 0.205 |
| R-HSA-6807070 | PTEN Regulation | 0.624820 | 0.204 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.626083 | 0.203 |
| R-HSA-1632852 | Macroautophagy | 0.631721 | 0.199 |
| R-HSA-8951664 | Neddylation | 0.634952 | 0.197 |
| R-HSA-196071 | Metabolism of steroid hormones | 0.638579 | 0.195 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.641888 | 0.193 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.643461 | 0.191 |
| R-HSA-5218859 | Regulated Necrosis | 0.643461 | 0.191 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.653030 | 0.185 |
| R-HSA-448424 | Interleukin-17 signaling | 0.653030 | 0.185 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.655100 | 0.184 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.657719 | 0.182 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.657719 | 0.182 |
| R-HSA-8978934 | Metabolism of cofactors | 0.657719 | 0.182 |
| R-HSA-166520 | Signaling by NTRKs | 0.658342 | 0.182 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.662344 | 0.179 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.662344 | 0.179 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.666907 | 0.176 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.671408 | 0.173 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.671408 | 0.173 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.671408 | 0.173 |
| R-HSA-380287 | Centrosome maturation | 0.675849 | 0.170 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.675849 | 0.170 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.675849 | 0.170 |
| R-HSA-9612973 | Autophagy | 0.683407 | 0.165 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.684553 | 0.165 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.684553 | 0.165 |
| R-HSA-157118 | Signaling by NOTCH | 0.685075 | 0.164 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.688817 | 0.162 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.697174 | 0.157 |
| R-HSA-9833482 | PKR-mediated signaling | 0.697174 | 0.157 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.702204 | 0.154 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.715403 | 0.145 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.717102 | 0.144 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.724703 | 0.140 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.727682 | 0.138 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.732100 | 0.135 |
| R-HSA-9663891 | Selective autophagy | 0.732100 | 0.135 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.739300 | 0.131 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.742827 | 0.129 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.749342 | 0.125 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.761666 | 0.118 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.763405 | 0.117 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.769387 | 0.114 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.772509 | 0.112 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.772509 | 0.112 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.772509 | 0.112 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.772509 | 0.112 |
| R-HSA-190236 | Signaling by FGFR | 0.772509 | 0.112 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.774182 | 0.111 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.780373 | 0.108 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.781624 | 0.107 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.790345 | 0.102 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.790376 | 0.102 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.794293 | 0.100 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.796015 | 0.099 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.797583 | 0.098 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.798778 | 0.098 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.801504 | 0.096 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.801504 | 0.096 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.801695 | 0.096 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.802722 | 0.095 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.804193 | 0.095 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.804193 | 0.095 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.806846 | 0.093 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.809462 | 0.092 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.809462 | 0.092 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.814591 | 0.089 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.817103 | 0.088 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.817103 | 0.088 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.822027 | 0.085 |
| R-HSA-8953854 | Metabolism of RNA | 0.823408 | 0.084 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.824439 | 0.084 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.824439 | 0.084 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.826819 | 0.083 |
| R-HSA-168256 | Immune System | 0.828573 | 0.082 |
| R-HSA-373760 | L1CAM interactions | 0.829166 | 0.081 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.836020 | 0.078 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.836020 | 0.078 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.840437 | 0.075 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.842600 | 0.074 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.842600 | 0.074 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.844735 | 0.073 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.846840 | 0.072 |
| R-HSA-69206 | G1/S Transition | 0.850967 | 0.070 |
| R-HSA-194138 | Signaling by VEGF | 0.850967 | 0.070 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.851956 | 0.070 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.853597 | 0.069 |
| R-HSA-109582 | Hemostasis | 0.856738 | 0.067 |
| R-HSA-9824446 | Viral Infection Pathways | 0.858065 | 0.066 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.864030 | 0.063 |
| R-HSA-9717189 | Sensory perception of taste | 0.864557 | 0.063 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.875579 | 0.058 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.881858 | 0.055 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.881858 | 0.055 |
| R-HSA-9664407 | Parasite infection | 0.881858 | 0.055 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.883463 | 0.054 |
| R-HSA-422475 | Axon guidance | 0.883725 | 0.054 |
| R-HSA-392499 | Metabolism of proteins | 0.889244 | 0.051 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.889665 | 0.051 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.895540 | 0.048 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.898359 | 0.047 |
| R-HSA-112316 | Neuronal System | 0.899710 | 0.046 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.899740 | 0.046 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.901102 | 0.045 |
| R-HSA-69306 | DNA Replication | 0.902446 | 0.045 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.912910 | 0.040 |
| R-HSA-9675108 | Nervous system development | 0.913478 | 0.039 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.923754 | 0.034 |
| R-HSA-418555 | G alpha (s) signalling events | 0.924791 | 0.034 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.927820 | 0.033 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.927898 | 0.032 |
| R-HSA-1483257 | Phospholipid metabolism | 0.927898 | 0.032 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.928802 | 0.032 |
| R-HSA-69275 | G2/M Transition | 0.938767 | 0.027 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.940424 | 0.027 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.940424 | 0.027 |
| R-HSA-983712 | Ion channel transport | 0.941235 | 0.026 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.942826 | 0.026 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.944373 | 0.025 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.945131 | 0.025 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.947419 | 0.023 |
| R-HSA-72172 | mRNA Splicing | 0.952819 | 0.021 |
| R-HSA-5357801 | Programmed Cell Death | 0.953463 | 0.021 |
| R-HSA-6805567 | Keratinization | 0.954097 | 0.020 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.957686 | 0.019 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.957728 | 0.019 |
| R-HSA-388396 | GPCR downstream signalling | 0.960410 | 0.018 |
| R-HSA-73894 | DNA Repair | 0.965627 | 0.015 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.966992 | 0.015 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.967187 | 0.014 |
| R-HSA-72312 | rRNA processing | 0.967888 | 0.014 |
| R-HSA-449147 | Signaling by Interleukins | 0.976639 | 0.010 |
| R-HSA-168249 | Innate Immune System | 0.978019 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 0.980671 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.983622 | 0.007 |
| R-HSA-9658195 | Leishmania infection | 0.983649 | 0.007 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.983649 | 0.007 |
| R-HSA-6798695 | Neutrophil degranulation | 0.989240 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992865 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.994053 | 0.003 |
| R-HSA-211859 | Biological oxidations | 0.995192 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.996627 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.996764 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997184 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999632 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999779 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999901 | 0.000 |
| R-HSA-1643685 | Disease | 0.999992 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.870 | 0.853 | 1 | 0.807 |
CDK18 |
0.867 | 0.858 | 1 | 0.825 |
HIPK2 |
0.864 | 0.795 | 1 | 0.814 |
CDK17 |
0.864 | 0.866 | 1 | 0.855 |
P38G |
0.863 | 0.883 | 1 | 0.865 |
CDK8 |
0.862 | 0.848 | 1 | 0.773 |
KIS |
0.861 | 0.767 | 1 | 0.759 |
CDK7 |
0.860 | 0.843 | 1 | 0.781 |
JNK2 |
0.860 | 0.889 | 1 | 0.824 |
P38D |
0.860 | 0.870 | 1 | 0.865 |
CDK3 |
0.855 | 0.753 | 1 | 0.851 |
ERK1 |
0.855 | 0.849 | 1 | 0.811 |
P38B |
0.855 | 0.857 | 1 | 0.799 |
CDK13 |
0.855 | 0.839 | 1 | 0.802 |
CDK16 |
0.854 | 0.827 | 1 | 0.843 |
CDK12 |
0.853 | 0.840 | 1 | 0.822 |
CDK1 |
0.852 | 0.820 | 1 | 0.806 |
DYRK2 |
0.850 | 0.771 | 1 | 0.728 |
CDK5 |
0.850 | 0.801 | 1 | 0.751 |
JNK3 |
0.848 | 0.868 | 1 | 0.799 |
DYRK4 |
0.846 | 0.775 | 1 | 0.825 |
CDK9 |
0.846 | 0.822 | 1 | 0.794 |
P38A |
0.844 | 0.835 | 1 | 0.724 |
CDK14 |
0.844 | 0.821 | 1 | 0.781 |
HIPK4 |
0.843 | 0.560 | 1 | 0.508 |
CDK10 |
0.842 | 0.771 | 1 | 0.798 |
HIPK1 |
0.841 | 0.722 | 1 | 0.706 |
DYRK1B |
0.837 | 0.747 | 1 | 0.775 |
ERK2 |
0.834 | 0.826 | 1 | 0.756 |
CLK3 |
0.834 | 0.503 | 1 | 0.477 |
CDK4 |
0.834 | 0.813 | 1 | 0.829 |
CDK6 |
0.833 | 0.790 | 1 | 0.800 |
HIPK3 |
0.833 | 0.709 | 1 | 0.677 |
DYRK1A |
0.832 | 0.646 | 1 | 0.684 |
NLK |
0.832 | 0.755 | 1 | 0.508 |
JNK1 |
0.829 | 0.778 | 1 | 0.826 |
SRPK1 |
0.828 | 0.375 | -3 | 0.764 |
ERK5 |
0.822 | 0.436 | 1 | 0.434 |
MAK |
0.820 | 0.553 | -2 | 0.803 |
CDK2 |
0.820 | 0.622 | 1 | 0.678 |
DYRK3 |
0.818 | 0.561 | 1 | 0.670 |
SRPK2 |
0.815 | 0.301 | -3 | 0.688 |
CLK1 |
0.814 | 0.431 | -3 | 0.745 |
ICK |
0.813 | 0.413 | -3 | 0.848 |
CLK2 |
0.813 | 0.419 | -3 | 0.749 |
CDKL5 |
0.812 | 0.219 | -3 | 0.809 |
MTOR |
0.811 | 0.261 | 1 | 0.297 |
MOK |
0.808 | 0.514 | 1 | 0.598 |
CLK4 |
0.806 | 0.383 | -3 | 0.760 |
CDKL1 |
0.804 | 0.186 | -3 | 0.813 |
SRPK3 |
0.801 | 0.265 | -3 | 0.734 |
COT |
0.798 | -0.104 | 2 | 0.791 |
CDC7 |
0.798 | -0.054 | 1 | 0.146 |
PRP4 |
0.797 | 0.447 | -3 | 0.726 |
PRKD1 |
0.797 | 0.060 | -3 | 0.837 |
TBK1 |
0.793 | -0.134 | 1 | 0.092 |
ERK7 |
0.792 | 0.283 | 2 | 0.506 |
PRPK |
0.792 | -0.066 | -1 | 0.855 |
NDR2 |
0.791 | -0.005 | -3 | 0.831 |
MOS |
0.790 | -0.029 | 1 | 0.187 |
PIM3 |
0.790 | -0.021 | -3 | 0.832 |
PRKD2 |
0.789 | 0.038 | -3 | 0.779 |
ATR |
0.788 | -0.038 | 1 | 0.169 |
CHAK2 |
0.787 | -0.005 | -1 | 0.833 |
NUAK2 |
0.787 | 0.034 | -3 | 0.832 |
IKKE |
0.787 | -0.155 | 1 | 0.092 |
GCN2 |
0.786 | -0.187 | 2 | 0.735 |
CAMK1B |
0.785 | -0.027 | -3 | 0.856 |
WNK1 |
0.784 | -0.062 | -2 | 0.883 |
ULK2 |
0.784 | -0.184 | 2 | 0.730 |
MST4 |
0.784 | -0.037 | 2 | 0.788 |
MARK4 |
0.783 | -0.012 | 4 | 0.886 |
P90RSK |
0.783 | 0.014 | -3 | 0.781 |
PKN3 |
0.783 | -0.044 | -3 | 0.824 |
RAF1 |
0.783 | -0.192 | 1 | 0.117 |
NEK6 |
0.783 | -0.075 | -2 | 0.855 |
PDHK4 |
0.783 | -0.160 | 1 | 0.182 |
BMPR2 |
0.782 | -0.161 | -2 | 0.869 |
AMPKA1 |
0.782 | -0.024 | -3 | 0.841 |
MAPKAPK3 |
0.781 | -0.020 | -3 | 0.780 |
RSK2 |
0.781 | -0.002 | -3 | 0.778 |
NDR1 |
0.781 | -0.051 | -3 | 0.822 |
IKKB |
0.781 | -0.181 | -2 | 0.733 |
NIK |
0.780 | -0.054 | -3 | 0.864 |
RSK3 |
0.780 | -0.010 | -3 | 0.773 |
PIM1 |
0.780 | 0.025 | -3 | 0.780 |
PDHK1 |
0.779 | -0.163 | 1 | 0.161 |
TGFBR2 |
0.779 | -0.089 | -2 | 0.760 |
TSSK1 |
0.779 | -0.009 | -3 | 0.860 |
AMPKA2 |
0.779 | -0.007 | -3 | 0.811 |
LATS2 |
0.779 | -0.031 | -5 | 0.804 |
MAPKAPK2 |
0.779 | -0.004 | -3 | 0.739 |
PKCD |
0.778 | -0.033 | 2 | 0.712 |
SKMLCK |
0.778 | -0.064 | -2 | 0.841 |
CAMLCK |
0.778 | -0.026 | -2 | 0.822 |
DAPK2 |
0.777 | -0.033 | -3 | 0.859 |
DSTYK |
0.777 | -0.183 | 2 | 0.795 |
PKN2 |
0.777 | -0.071 | -3 | 0.822 |
NEK7 |
0.776 | -0.180 | -3 | 0.840 |
MPSK1 |
0.776 | 0.100 | 1 | 0.183 |
PRKD3 |
0.776 | 0.019 | -3 | 0.753 |
NIM1 |
0.775 | -0.054 | 3 | 0.774 |
NUAK1 |
0.775 | -0.005 | -3 | 0.783 |
CAMK2D |
0.775 | -0.080 | -3 | 0.840 |
IRE1 |
0.775 | -0.092 | 1 | 0.113 |
MLK2 |
0.774 | -0.106 | 2 | 0.752 |
CAMK2G |
0.774 | -0.131 | 2 | 0.735 |
AURC |
0.774 | -0.001 | -2 | 0.599 |
QSK |
0.773 | 0.011 | 4 | 0.874 |
ULK1 |
0.773 | -0.183 | -3 | 0.812 |
PHKG1 |
0.773 | -0.051 | -3 | 0.812 |
WNK3 |
0.773 | -0.192 | 1 | 0.112 |
NEK9 |
0.772 | -0.163 | 2 | 0.774 |
TSSK2 |
0.772 | -0.062 | -5 | 0.875 |
RIPK3 |
0.772 | -0.172 | 3 | 0.737 |
MASTL |
0.771 | -0.161 | -2 | 0.818 |
IKKA |
0.771 | -0.118 | -2 | 0.733 |
LATS1 |
0.771 | 0.013 | -3 | 0.838 |
MLK1 |
0.770 | -0.181 | 2 | 0.731 |
P70S6KB |
0.770 | -0.029 | -3 | 0.790 |
MELK |
0.770 | -0.057 | -3 | 0.796 |
HUNK |
0.770 | -0.167 | 2 | 0.738 |
PKACG |
0.770 | -0.054 | -2 | 0.693 |
SMG1 |
0.770 | -0.047 | 1 | 0.154 |
MNK2 |
0.769 | -0.050 | -2 | 0.763 |
VRK2 |
0.769 | 0.069 | 1 | 0.221 |
PKCB |
0.769 | -0.040 | 2 | 0.658 |
DNAPK |
0.769 | -0.039 | 1 | 0.153 |
PKCA |
0.768 | -0.031 | 2 | 0.655 |
BCKDK |
0.768 | -0.169 | -1 | 0.775 |
PINK1 |
0.768 | 0.165 | 1 | 0.328 |
SIK |
0.768 | -0.010 | -3 | 0.751 |
IRE2 |
0.768 | -0.089 | 2 | 0.685 |
PAK3 |
0.768 | -0.084 | -2 | 0.758 |
MLK3 |
0.767 | -0.083 | 2 | 0.660 |
QIK |
0.767 | -0.066 | -3 | 0.823 |
PKCZ |
0.766 | -0.056 | 2 | 0.718 |
GRK5 |
0.766 | -0.195 | -3 | 0.827 |
GRK1 |
0.766 | -0.083 | -2 | 0.742 |
BMPR1B |
0.766 | -0.068 | 1 | 0.117 |
PKR |
0.766 | -0.093 | 1 | 0.135 |
PKCG |
0.765 | -0.054 | 2 | 0.655 |
RIPK1 |
0.765 | -0.201 | 1 | 0.102 |
ATM |
0.765 | -0.092 | 1 | 0.140 |
CHAK1 |
0.765 | -0.111 | 2 | 0.750 |
ALK4 |
0.765 | -0.076 | -2 | 0.799 |
SGK3 |
0.765 | -0.012 | -3 | 0.758 |
TGFBR1 |
0.764 | -0.072 | -2 | 0.771 |
PIM2 |
0.764 | 0.028 | -3 | 0.749 |
PAK1 |
0.764 | -0.074 | -2 | 0.757 |
AKT2 |
0.764 | 0.021 | -3 | 0.695 |
MARK3 |
0.764 | -0.005 | 4 | 0.838 |
MNK1 |
0.764 | -0.040 | -2 | 0.764 |
NEK2 |
0.764 | -0.120 | 2 | 0.762 |
DLK |
0.763 | -0.231 | 1 | 0.127 |
PAK6 |
0.763 | -0.037 | -2 | 0.673 |
GSK3A |
0.763 | 0.190 | 4 | 0.458 |
BRSK2 |
0.763 | -0.069 | -3 | 0.804 |
ANKRD3 |
0.763 | -0.205 | 1 | 0.129 |
RSK4 |
0.762 | -0.010 | -3 | 0.748 |
PKACB |
0.762 | -0.005 | -2 | 0.620 |
MSK2 |
0.762 | -0.055 | -3 | 0.754 |
MARK2 |
0.762 | -0.016 | 4 | 0.803 |
CAMK4 |
0.761 | -0.129 | -3 | 0.805 |
YSK4 |
0.761 | -0.168 | 1 | 0.098 |
DCAMKL1 |
0.761 | -0.035 | -3 | 0.774 |
GRK7 |
0.761 | -0.040 | 1 | 0.150 |
CHK1 |
0.761 | -0.037 | -3 | 0.818 |
PKG2 |
0.760 | -0.035 | -2 | 0.619 |
CAMK2A |
0.760 | -0.043 | 2 | 0.713 |
BRSK1 |
0.760 | -0.057 | -3 | 0.785 |
TTBK2 |
0.760 | -0.211 | 2 | 0.656 |
AURB |
0.760 | -0.038 | -2 | 0.596 |
MEK1 |
0.759 | -0.145 | 2 | 0.779 |
PKCH |
0.759 | -0.079 | 2 | 0.644 |
CAMK2B |
0.759 | -0.080 | 2 | 0.699 |
FAM20C |
0.758 | -0.043 | 2 | 0.556 |
BUB1 |
0.758 | 0.085 | -5 | 0.849 |
WNK4 |
0.758 | -0.095 | -2 | 0.890 |
PLK4 |
0.758 | -0.128 | 2 | 0.574 |
GRK6 |
0.757 | -0.191 | 1 | 0.120 |
MAPKAPK5 |
0.756 | -0.074 | -3 | 0.727 |
IRAK4 |
0.755 | -0.120 | 1 | 0.094 |
MSK1 |
0.755 | -0.044 | -3 | 0.753 |
SSTK |
0.755 | -0.040 | 4 | 0.859 |
PLK1 |
0.755 | -0.174 | -2 | 0.787 |
TLK2 |
0.755 | -0.142 | 1 | 0.103 |
MLK4 |
0.755 | -0.143 | 2 | 0.643 |
ACVR2B |
0.755 | -0.114 | -2 | 0.769 |
PAK2 |
0.755 | -0.104 | -2 | 0.738 |
AKT1 |
0.754 | -0.004 | -3 | 0.708 |
PKCT |
0.754 | -0.065 | 2 | 0.654 |
PHKG2 |
0.753 | -0.083 | -3 | 0.781 |
MST3 |
0.753 | -0.066 | 2 | 0.766 |
ACVR2A |
0.753 | -0.121 | -2 | 0.756 |
MEKK1 |
0.752 | -0.157 | 1 | 0.122 |
MARK1 |
0.752 | -0.058 | 4 | 0.850 |
TAO3 |
0.752 | -0.055 | 1 | 0.143 |
CAMK1G |
0.752 | -0.062 | -3 | 0.761 |
PRKX |
0.752 | 0.005 | -3 | 0.670 |
MYLK4 |
0.752 | -0.068 | -2 | 0.724 |
DCAMKL2 |
0.751 | -0.055 | -3 | 0.800 |
PERK |
0.751 | -0.158 | -2 | 0.811 |
NEK5 |
0.751 | -0.141 | 1 | 0.108 |
SNRK |
0.751 | -0.163 | 2 | 0.630 |
ZAK |
0.751 | -0.172 | 1 | 0.107 |
PKCI |
0.751 | -0.040 | 2 | 0.683 |
MEK5 |
0.750 | -0.174 | 2 | 0.760 |
HRI |
0.750 | -0.169 | -2 | 0.834 |
ALK2 |
0.750 | -0.116 | -2 | 0.774 |
GRK4 |
0.749 | -0.230 | -2 | 0.781 |
LKB1 |
0.749 | -0.024 | -3 | 0.820 |
GSK3B |
0.749 | 0.044 | 4 | 0.453 |
P70S6K |
0.748 | -0.037 | -3 | 0.710 |
PLK3 |
0.748 | -0.151 | 2 | 0.701 |
MAP3K15 |
0.748 | -0.064 | 1 | 0.118 |
MEKK2 |
0.748 | -0.153 | 2 | 0.735 |
PDK1 |
0.747 | -0.055 | 1 | 0.153 |
PBK |
0.747 | -0.007 | 1 | 0.157 |
SBK |
0.747 | 0.120 | -3 | 0.588 |
PKN1 |
0.747 | -0.032 | -3 | 0.727 |
DRAK1 |
0.747 | -0.179 | 1 | 0.088 |
BMPR1A |
0.746 | -0.088 | 1 | 0.108 |
BRAF |
0.746 | -0.173 | -4 | 0.796 |
MEKK6 |
0.745 | -0.082 | 1 | 0.122 |
PAK5 |
0.745 | -0.064 | -2 | 0.607 |
AURA |
0.745 | -0.070 | -2 | 0.562 |
HGK |
0.745 | -0.058 | 3 | 0.891 |
TAO2 |
0.744 | -0.074 | 2 | 0.777 |
PASK |
0.744 | -0.057 | -3 | 0.853 |
PKACA |
0.744 | -0.023 | -2 | 0.564 |
PKCE |
0.744 | -0.024 | 2 | 0.645 |
SMMLCK |
0.744 | -0.061 | -3 | 0.817 |
AKT3 |
0.744 | 0.009 | -3 | 0.641 |
NEK11 |
0.743 | -0.141 | 1 | 0.133 |
GAK |
0.743 | -0.064 | 1 | 0.172 |
GRK2 |
0.742 | -0.126 | -2 | 0.663 |
CK1E |
0.742 | -0.054 | -3 | 0.521 |
NEK4 |
0.742 | -0.131 | 1 | 0.093 |
HASPIN |
0.742 | 0.049 | -1 | 0.758 |
TNIK |
0.742 | -0.045 | 3 | 0.890 |
SGK1 |
0.742 | 0.029 | -3 | 0.620 |
TLK1 |
0.742 | -0.173 | -2 | 0.798 |
CAMK1D |
0.741 | -0.042 | -3 | 0.691 |
PAK4 |
0.741 | -0.058 | -2 | 0.609 |
GCK |
0.741 | -0.085 | 1 | 0.118 |
KHS1 |
0.740 | -0.034 | 1 | 0.114 |
MINK |
0.740 | -0.104 | 1 | 0.095 |
MEKK3 |
0.740 | -0.232 | 1 | 0.118 |
LRRK2 |
0.740 | -0.023 | 2 | 0.786 |
CHK2 |
0.739 | -0.010 | -3 | 0.642 |
CAMKK2 |
0.739 | -0.132 | -2 | 0.758 |
NEK1 |
0.738 | -0.118 | 1 | 0.091 |
CAMKK1 |
0.738 | -0.190 | -2 | 0.762 |
LOK |
0.738 | -0.078 | -2 | 0.758 |
HPK1 |
0.738 | -0.079 | 1 | 0.119 |
NEK8 |
0.737 | -0.193 | 2 | 0.751 |
DAPK3 |
0.737 | -0.055 | -3 | 0.790 |
AAK1 |
0.737 | 0.033 | 1 | 0.176 |
KHS2 |
0.736 | -0.023 | 1 | 0.123 |
TTBK1 |
0.736 | -0.179 | 2 | 0.579 |
CK1D |
0.736 | -0.029 | -3 | 0.470 |
NEK3 |
0.735 | -0.078 | 1 | 0.121 |
CAMK1A |
0.735 | -0.019 | -3 | 0.663 |
IRAK1 |
0.735 | -0.220 | -1 | 0.755 |
MRCKB |
0.734 | -0.023 | -3 | 0.732 |
BIKE |
0.734 | -0.013 | 1 | 0.166 |
EEF2K |
0.734 | -0.096 | 3 | 0.847 |
ROCK2 |
0.734 | -0.026 | -3 | 0.775 |
CK1G1 |
0.733 | -0.090 | -3 | 0.502 |
MST2 |
0.733 | -0.165 | 1 | 0.108 |
MRCKA |
0.733 | -0.031 | -3 | 0.743 |
YSK1 |
0.733 | -0.103 | 2 | 0.747 |
VRK1 |
0.732 | -0.158 | 2 | 0.764 |
PDHK3_TYR |
0.729 | 0.137 | 4 | 0.896 |
LIMK2_TYR |
0.729 | 0.162 | -3 | 0.879 |
DAPK1 |
0.728 | -0.066 | -3 | 0.776 |
DMPK1 |
0.728 | 0.008 | -3 | 0.752 |
CK1A2 |
0.728 | -0.058 | -3 | 0.471 |
SLK |
0.728 | -0.093 | -2 | 0.698 |
MEK2 |
0.728 | -0.176 | 2 | 0.757 |
CK2A2 |
0.728 | -0.106 | 1 | 0.109 |
CRIK |
0.727 | 0.013 | -3 | 0.718 |
TAK1 |
0.727 | -0.215 | 1 | 0.101 |
MST1 |
0.726 | -0.165 | 1 | 0.096 |
STK33 |
0.726 | -0.140 | 2 | 0.566 |
PKMYT1_TYR |
0.724 | 0.149 | 3 | 0.853 |
GRK3 |
0.724 | -0.134 | -2 | 0.609 |
RIPK2 |
0.724 | -0.223 | 1 | 0.091 |
PKG1 |
0.723 | -0.056 | -2 | 0.531 |
ASK1 |
0.722 | -0.108 | 1 | 0.120 |
TESK1_TYR |
0.721 | 0.034 | 3 | 0.885 |
MYO3B |
0.721 | -0.066 | 2 | 0.771 |
ROCK1 |
0.720 | -0.039 | -3 | 0.740 |
PLK2 |
0.720 | -0.100 | -3 | 0.790 |
TAO1 |
0.720 | -0.089 | 1 | 0.111 |
MAP2K4_TYR |
0.718 | 0.014 | -1 | 0.870 |
OSR1 |
0.718 | -0.110 | 2 | 0.746 |
PDHK4_TYR |
0.717 | 0.022 | 2 | 0.810 |
CK2A1 |
0.717 | -0.114 | 1 | 0.100 |
MYO3A |
0.715 | -0.097 | 1 | 0.113 |
MAP2K7_TYR |
0.714 | -0.099 | 2 | 0.789 |
TTK |
0.714 | -0.114 | -2 | 0.794 |
MAP2K6_TYR |
0.713 | -0.023 | -1 | 0.865 |
LIMK1_TYR |
0.712 | 0.004 | 2 | 0.793 |
BMPR2_TYR |
0.711 | -0.032 | -1 | 0.846 |
RET |
0.710 | -0.131 | 1 | 0.140 |
PINK1_TYR |
0.710 | -0.153 | 1 | 0.175 |
NEK10_TYR |
0.710 | -0.062 | 1 | 0.118 |
JAK2 |
0.710 | -0.097 | 1 | 0.151 |
JAK1 |
0.709 | -0.037 | 1 | 0.118 |
TYK2 |
0.709 | -0.164 | 1 | 0.129 |
PDHK1_TYR |
0.709 | -0.086 | -1 | 0.861 |
MST1R |
0.709 | -0.092 | 3 | 0.835 |
CSF1R |
0.708 | -0.086 | 3 | 0.816 |
ROS1 |
0.708 | -0.109 | 3 | 0.804 |
TNNI3K_TYR |
0.706 | -0.026 | 1 | 0.162 |
TNK1 |
0.705 | -0.036 | 3 | 0.805 |
TYRO3 |
0.705 | -0.148 | 3 | 0.831 |
TNK2 |
0.705 | -0.071 | 3 | 0.786 |
EPHA6 |
0.704 | -0.119 | -1 | 0.805 |
ABL2 |
0.704 | -0.103 | -1 | 0.783 |
EPHB4 |
0.703 | -0.132 | -1 | 0.790 |
ALPHAK3 |
0.703 | -0.127 | -1 | 0.744 |
YANK3 |
0.703 | -0.076 | 2 | 0.371 |
TXK |
0.702 | -0.095 | 1 | 0.110 |
JAK3 |
0.701 | -0.136 | 1 | 0.135 |
ABL1 |
0.701 | -0.107 | -1 | 0.778 |
YES1 |
0.701 | -0.107 | -1 | 0.839 |
LCK |
0.700 | -0.085 | -1 | 0.801 |
FGFR1 |
0.699 | -0.048 | 3 | 0.784 |
STLK3 |
0.699 | -0.197 | 1 | 0.091 |
DDR1 |
0.699 | -0.146 | 4 | 0.818 |
TEK |
0.698 | -0.024 | 3 | 0.758 |
FGFR2 |
0.698 | -0.074 | 3 | 0.796 |
HCK |
0.697 | -0.136 | -1 | 0.805 |
BLK |
0.696 | -0.085 | -1 | 0.805 |
FGR |
0.696 | -0.171 | 1 | 0.110 |
ITK |
0.695 | -0.149 | -1 | 0.778 |
PDGFRB |
0.693 | -0.198 | 3 | 0.832 |
FLT3 |
0.693 | -0.176 | 3 | 0.827 |
KIT |
0.693 | -0.142 | 3 | 0.813 |
KDR |
0.693 | -0.113 | 3 | 0.771 |
INSRR |
0.692 | -0.164 | 3 | 0.763 |
CK1A |
0.692 | -0.077 | -3 | 0.377 |
PDGFRA |
0.691 | -0.181 | 3 | 0.832 |
FER |
0.691 | -0.209 | 1 | 0.128 |
EPHB1 |
0.690 | -0.182 | 1 | 0.110 |
AXL |
0.690 | -0.170 | 3 | 0.792 |
SRMS |
0.690 | -0.192 | 1 | 0.105 |
EPHA4 |
0.690 | -0.121 | 2 | 0.699 |
DDR2 |
0.690 | -0.047 | 3 | 0.751 |
MET |
0.689 | -0.129 | 3 | 0.812 |
MERTK |
0.689 | -0.160 | 3 | 0.786 |
EPHB3 |
0.688 | -0.179 | -1 | 0.768 |
BMX |
0.688 | -0.124 | -1 | 0.705 |
EPHB2 |
0.687 | -0.171 | -1 | 0.763 |
WEE1_TYR |
0.686 | -0.098 | -1 | 0.738 |
ALK |
0.686 | -0.151 | 3 | 0.753 |
TEC |
0.685 | -0.159 | -1 | 0.720 |
BTK |
0.684 | -0.205 | -1 | 0.756 |
FGFR3 |
0.683 | -0.103 | 3 | 0.765 |
EPHA1 |
0.683 | -0.157 | 3 | 0.799 |
FRK |
0.683 | -0.157 | -1 | 0.800 |
FYN |
0.683 | -0.112 | -1 | 0.785 |
LTK |
0.681 | -0.174 | 3 | 0.762 |
PTK2B |
0.681 | -0.116 | -1 | 0.754 |
EPHA7 |
0.681 | -0.152 | 2 | 0.707 |
INSR |
0.679 | -0.175 | 3 | 0.742 |
PTK6 |
0.679 | -0.203 | -1 | 0.710 |
ERBB2 |
0.678 | -0.189 | 1 | 0.113 |
NTRK1 |
0.677 | -0.233 | -1 | 0.787 |
LYN |
0.677 | -0.151 | 3 | 0.727 |
EGFR |
0.677 | -0.128 | 1 | 0.093 |
NTRK2 |
0.677 | -0.222 | 3 | 0.763 |
NTRK3 |
0.677 | -0.164 | -1 | 0.738 |
FLT4 |
0.676 | -0.185 | 3 | 0.746 |
FLT1 |
0.675 | -0.186 | -1 | 0.774 |
EPHA3 |
0.675 | -0.171 | 2 | 0.674 |
SRC |
0.674 | -0.142 | -1 | 0.785 |
MATK |
0.674 | -0.123 | -1 | 0.708 |
MUSK |
0.674 | -0.139 | 1 | 0.077 |
EPHA8 |
0.671 | -0.146 | -1 | 0.745 |
FGFR4 |
0.670 | -0.130 | -1 | 0.729 |
CSK |
0.669 | -0.168 | 2 | 0.709 |
EPHA5 |
0.669 | -0.180 | 2 | 0.678 |
YANK2 |
0.667 | -0.099 | 2 | 0.383 |
PTK2 |
0.666 | -0.097 | -1 | 0.739 |
ERBB4 |
0.663 | -0.120 | 1 | 0.098 |
SYK |
0.662 | -0.130 | -1 | 0.719 |
CK1G3 |
0.662 | -0.097 | -3 | 0.329 |
EPHA2 |
0.662 | -0.156 | -1 | 0.712 |
IGF1R |
0.659 | -0.177 | 3 | 0.672 |
ZAP70 |
0.655 | -0.086 | -1 | 0.661 |
FES |
0.650 | -0.156 | -1 | 0.681 |
CK1G2 |
0.638 | -0.108 | -3 | 0.420 |