Motif 229 (n=204)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JNW5 | BLTP3B | S423 | ochoa | Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like) | Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269|PubMed:20163565, ECO:0000269|PubMed:35499567}. |
| A1L390 | PLEKHG3 | S1037 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NF01 | POM121B | Y547 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NJT0 | UNCX | S443 | ochoa | Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) | Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}. |
| A7MCY6 | TBKBP1 | S388 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| A7MCY6 | TBKBP1 | S400 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| A8CG34 | POM121C | Y940 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B8ZZF3 | None | S345 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| C9J069 | AJM1 | S109 | ochoa | Apical junction component 1 homolog | May be involved in the control of adherens junction integrity. {ECO:0000250|UniProtKB:A0A1C3NSL9}. |
| O00267 | SUPT5H | S671 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14526 | FCHO1 | S530 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14686 | KMT2D | S2423 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15063 | GARRE1 | S723 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O15209 | ZBTB22 | S592 | ochoa | Zinc finger and BTB domain-containing protein 22 (Protein BING1) (Zinc finger and BTB domain-containing protein 22A) (Zinc finger protein 297) | May be involved in transcriptional regulation. |
| O15211 | RGL2 | S607 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15417 | TNRC18 | S1136 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43159 | RRP8 | S176 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O43283 | MAP3K13 | S572 | ochoa | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| O43312 | MTSS1 | S721 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43561 | LAT | S84 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43593 | HR | S316 | ochoa | Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. {ECO:0000269|PubMed:24334705}. |
| O60496 | DOK2 | S269 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| O75061 | DNAJC6 | S714 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
| O75970 | MPDZ | S790 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O94967 | WDR47 | S297 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95271 | TNKS | S987 | psp | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245). {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:28619731}. |
| O95359 | TACC2 | S137 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95402 | MED26 | S337 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95644 | NFATC1 | S117 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95785 | WIZ | S968 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95785 | WIZ | S1314 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95785 | WIZ | S1335 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| O95817 | BAG3 | S386 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P04150 | NR3C1 | S404 | ochoa|psp | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P10398 | ARAF | S186 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P15336 | ATF2 | S121 | psp | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P17600 | SYN1 | S67 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18887 | XRCC1 | S266 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P20719 | HOXA5 | S104 | ochoa | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
| P20823 | HNF1A | S313 | ochoa | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
| P25054 | APC | S2260 | ochoa|psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26045 | PTPN3 | S381 | ochoa|psp | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) | May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. |
| P26651 | ZFP36 | S93 | ochoa|psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P27708 | CAD | S1900 | ochoa|psp | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P29374 | ARID4A | S1145 | ochoa|psp | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
| P35712 | SOX6 | S439 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P39880 | CUX1 | S914 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41162 | ETV3 | S245 | ochoa|psp | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P42684 | ABL2 | S936 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P46087 | NOP2 | S732 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46527 | CDKN1B | S106 | ochoa | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
| P47974 | ZFP36L2 | S75 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48634 | PRRC2A | S137 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49757 | NUMB | S361 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P50548 | ERF | S246 | psp | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P53814 | SMTN | S277 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P54727 | RAD23B | S160 | ochoa | UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. |
| P56945 | BCAR1 | S139 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P78559 | MAP1A | S2427 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P84022 | SMAD3 | S213 | ochoa|psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| Q00613 | HSF1 | S292 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01484 | ANK2 | S2472 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q07157 | TJP1 | S912 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07889 | SOS1 | S1167 | ochoa|psp | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q08999 | RBL2 | S1044 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q09472 | EP300 | T938 | psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q0JRZ9 | FCHO2 | S474 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12772 | SREBF2 | S106 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12774 | ARHGEF5 | Y526 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q13112 | CHAF1B | S458 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13428 | TCOF1 | S1116 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13443 | ADAM9 | S758 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q14005 | IL16 | S908 | ochoa | Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Q14694 | USP10 | S355 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| Q14839 | CHD4 | S531 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
| Q15434 | RBMS2 | S285 | ochoa | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | None |
| Q15596 | NCOA2 | S487 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15642 | TRIP10 | S501 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| Q15788 | NCOA1 | S1006 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q15788 | NCOA1 | S1185 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q15797 | SMAD1 | S187 | psp | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q15911 | ZFHX3 | S3418 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q17R89 | ARHGAP44 | S640 | ochoa | Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2) | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}. |
| Q2KJY2 | KIF26B | S1021 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q2M3G4 | SHROOM1 | S188 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q3KQU3 | MAP7D1 | S125 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3T8J9 | GON4L | S1255 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q5JSZ5 | PRRC2B | S745 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5PRF9 | SAMD4B | S592 | ochoa|psp | Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) | Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}. |
| Q5QP82 | DCAF10 | S89 | ochoa | DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32) | May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. |
| Q5T035 | FAM120A2P | S45 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T1M5 | FKBP15 | S979 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5TC79 | ZBTB37 | S465 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
| Q5TDH0 | DDI2 | S106 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q5TGY3 | AHDC1 | S1458 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5TZA2 | CROCC | S1460 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VT06 | CEP350 | S567 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUA4 | ZNF318 | S2035 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VV67 | PPRC1 | S842 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q63HK5 | TSHZ3 | S463 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q63HR2 | TNS2 | S991 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q63HR2 | TNS2 | S1000 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q6AI12 | ANKRD40 | S160 | ochoa | Ankyrin repeat domain-containing protein 40 | None |
| Q6B0I6 | KDM4D | S505 | ochoa | Lysine-specific demethylase 4D (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D) ([histone H3]-trimethyl-L-lysine(9) demethylase 4D) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:35145029}. |
| Q6ICG6 | KIAA0930 | S276 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6P0Q8 | MAST2 | S209 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P4R8 | NFRKB | S896 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6P995 | FAM171B | S779 | ochoa | Protein FAM171B | None |
| Q6PCB5 | RSBN1L | S79 | ochoa | Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein) | Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250|UniProtKB:Q80T69}. |
| Q6Q6R5 | CRIP3 | S96 | ochoa | Cysteine-rich protein 3 (CRP-3) (Chromosome 6 LIM domain only protein) (h6LIMo) | None |
| Q6UB99 | ANKRD11 | S1852 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UUV7 | CRTC3 | S396 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
| Q6UUV9 | CRTC1 | S312 | ochoa | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}. |
| Q6ZS17 | RIPOR1 | S717 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
| Q6ZU65 | UBN2 | S1093 | ochoa | Ubinuclein-2 | None |
| Q6ZUT6 | CCDC9B | S392 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q70SY1 | CREB3L2 | S234 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q7Z3K3 | POGZ | S292 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z4K8 | TRIM46 | S88 | ochoa | Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein) | Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration. {ECO:0000250|UniProtKB:Q7TNM2}. |
| Q7Z591 | AKNA | S316 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S1192 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6J9 | TSEN54 | S249 | ochoa | tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54) | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}. |
| Q86X51 | EZHIP | S259 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86X51 | EZHIP | S452 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86YV5 | PRAG1 | S805 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IUW5 | RELL1 | S166 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IWC1 | MAP7D3 | S290 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX07 | ZFPM1 | S61 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S768 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IY33 | MICALL2 | S503 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IZY2 | ABCA7 | S804 | ochoa | Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter) | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}. |
| Q8N1G0 | ZNF687 | S215 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1I0 | DOCK4 | S1620 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N328 | PGBD3 | S86 | ochoa | PiggyBac transposable element-derived protein 3 | Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:22483866}. |
| Q8N3F8 | MICALL1 | S391 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S621 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3V7 | SYNPO | S828 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N6T7 | SIRT6 | S303 | ochoa|psp | NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6) | NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626, PubMed:21680843, PubMed:23217706, PubMed:23552949, PubMed:23653361, PubMed:24052263, PubMed:27180906, PubMed:27322069, PubMed:29555651, PubMed:30374165). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (PubMed:23552949, PubMed:24052263, PubMed:27322069). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:19625767, PubMed:21362626, PubMed:23892288, PubMed:23911928, PubMed:24012758, PubMed:26456828, PubMed:26898756, PubMed:27043296, PubMed:27180906, PubMed:30374165, PubMed:33067423). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (By similarity). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (PubMed:23911928, PubMed:31995034, PubMed:32538779). SIRT6 participation to DSB repair is probably involved in extension of life span (By similarity). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (PubMed:29474172, PubMed:32789493). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (PubMed:27043296). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (PubMed:18337721, PubMed:19625767, PubMed:21847107). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (PubMed:25915124, PubMed:29555651). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:24012758, PubMed:26787900). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (By similarity). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (PubMed:23217706). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (PubMed:26787900). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (PubMed:23142079, PubMed:25009184). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (By similarity). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (By similarity). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (By similarity). The defatty-acylase activity is specifically involved in regulation of protein secretion (PubMed:23552949, PubMed:24052263, PubMed:27322069, PubMed:28406396). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (PubMed:23552949, PubMed:28406396). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (PubMed:21680843, PubMed:22753495, PubMed:27322069, PubMed:27568560). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (PubMed:21680843, PubMed:22753495, PubMed:27568560). {ECO:0000250|UniProtKB:P59941, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889, ECO:0000269|PubMed:19625767, ECO:0000269|PubMed:21362626, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:21847107, ECO:0000269|PubMed:22753495, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23217706, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:23653361, ECO:0000269|PubMed:23892288, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:24012758, ECO:0000269|PubMed:24052263, ECO:0000269|PubMed:25009184, ECO:0000269|PubMed:25915124, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:26898756, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27180906, ECO:0000269|PubMed:27322069, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:28406396, ECO:0000269|PubMed:29474172, ECO:0000269|PubMed:29555651, ECO:0000269|PubMed:30374165, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:32789493, ECO:0000269|PubMed:33067423}. |
| Q8NC74 | RBBP8NL | S487 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8ND56 | LSM14A | S192 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDV7 | TNRC6A | S1750 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NDX1 | PSD4 | S448 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NEM7 | SUPT20H | S509 | ochoa | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}. |
| Q8NFU7 | TET1 | S871 | ochoa | Methylcytosine dioxygenase TET1 (EC 1.14.11.80) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) | Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093, ECO:0000269|PubMed:35798741}.; FUNCTION: [Isoform 1]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}.; FUNCTION: [Isoform 2]: Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity). {ECO:0000250|UniProtKB:Q3URK3, ECO:0000269|PubMed:28531272}. |
| Q8NHG8 | ZNRF2 | S151 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8TD55 | PLEKHO2 | S217 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8WUA4 | GTF3C2 | S765 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WWM7 | ATXN2L | S409 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92508 | PIEZO1 | S1391 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92551 | IP6K1 | S382 | ochoa | Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) | Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. |
| Q92574 | TSC1 | S403 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92766 | RREB1 | S1140 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92786 | PROX1 | S467 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q92835 | INPP5D | S1057 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q969H4 | CNKSR1 | S314 | ochoa | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | May function as an adapter protein or regulator of Ras signaling pathways. |
| Q96D71 | REPS1 | S401 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96HA1 | POM121 | Y963 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96JN0 | LCOR | S42 | ochoa | Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2) | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}. |
| Q96KN4 | LRATD1 | S67 | ochoa | Protein LRATD1 (LRAT domain-containing 1) (Neurologic sensory protein 1) (NSE1) (Protein FAM84A) | May play a role in cell morphology and motility. {ECO:0000269|PubMed:16820875}. |
| Q96L91 | EP400 | S722 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96N67 | DOCK7 | S864 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96PC5 | MIA2 | S1130 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PK6 | RBM14 | S220 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96S94 | CCNL2 | S441 | ochoa | Cyclin-L2 (Paneth cell-enhanced expression protein) | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}. |
| Q99501 | GAS2L1 | S306 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99700 | ATXN2 | S733 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99929 | ASCL2 | S142 | ochoa | Achaete-scute homolog 2 (ASH-2) (hASH2) (Class A basic helix-loop-helix protein 45) (bHLHa45) (Mash2) | Transcription factor. Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells. May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (By similarity). {ECO:0000250|UniProtKB:O35885, ECO:0000250|UniProtKB:P19360}. |
| Q99952 | PTPN18 | S419 | ochoa | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) | Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. |
| Q9BQI5 | SGIP1 | S265 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BRK4 | LZTS2 | S242 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
| Q9BUR4 | WRAP53 | S26 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BV36 | MLPH | S266 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BY89 | KIAA1671 | S1757 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0D6 | FHDC1 | S525 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H2E6 | SEMA6A | S808 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H2Y7 | ZNF106 | S452 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4Z2 | ZNF335 | S976 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9H6K5 | PRR36 | S302 | ochoa | Proline-rich protein 36 | None |
| Q9H7S9 | ZNF703 | S87 | ochoa | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}. |
| Q9H869 | YY1AP1 | S711 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9H9J4 | USP42 | S432 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9HAH7 | FBRS | S219 | ochoa | Probable fibrosin-1 | None |
| Q9NQS7 | INCENP | S421 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NR55 | BATF3 | S31 | ochoa | Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (21 kDa small nuclear factor isolated from T-cells) (Jun dimerization protein p21SNFT) | AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269|PubMed:10878360, ECO:0000269|PubMed:12087103, ECO:0000269|PubMed:15467742}. |
| Q9NRR6 | INPP5E | S47 | ochoa | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}. |
| Q9NVT9 | ARMC1 | S246 | ochoa | Armadillo repeat-containing protein 1 | In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility. {ECO:0000269|PubMed:31644573}. |
| Q9NW07 | ZNF358 | S146 | ochoa | Zinc finger protein 358 | May be involved in transcriptional regulation. |
| Q9NWS9 | ZNF446 | S146 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NX94 | WBP1L | S168 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NZB2 | FAM120A | S396 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P0U4 | CXXC1 | S224 | ochoa | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. {ECO:0000269|PubMed:21407193}. |
| Q9P1Y5 | CAMSAP3 | T525 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P275 | USP36 | S667 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UGI9 | PRKAG3 | S86 | ochoa | 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:17878938, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism (PubMed:17878938). It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:17878938, ECO:0000269|PubMed:24563466}. |
| Q9UJM3 | ERRFI1 | S136 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UKK3 | PARP4 | S1340 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9ULD5 | ZNF777 | S143 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9UQB3 | CTNND2 | S276 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9UQB3 | CTNND2 | S1065 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
| Q9Y4B4 | RAD54L2 | S1421 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4R8 | TELO2 | S637 | ochoa | Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2) | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}. |
| Q9Y4U1 | MMACHC | S247 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
| Q9Y6X9 | MORC2 | S705 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| P08151 | GLI1 | S927 | GPS6 | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000004 | 5.425 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000004 | 5.374 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.000041 | 4.385 |
| R-HSA-9707616 | Heme signaling | 0.000061 | 4.218 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000509 | 3.293 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.000906 | 3.043 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.001570 | 2.804 |
| R-HSA-212436 | Generic Transcription Pathway | 0.001641 | 2.785 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.002422 | 2.616 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.005582 | 2.253 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.005582 | 2.253 |
| R-HSA-9843745 | Adipogenesis | 0.004523 | 2.345 |
| R-HSA-3214847 | HATs acetylate histones | 0.004423 | 2.354 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005582 | 2.253 |
| R-HSA-9909396 | Circadian clock | 0.004689 | 2.329 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.002950 | 2.530 |
| R-HSA-5688426 | Deubiquitination | 0.005109 | 2.292 |
| R-HSA-4839726 | Chromatin organization | 0.004394 | 2.357 |
| R-HSA-9607240 | FLT3 Signaling | 0.004575 | 2.340 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007002 | 2.155 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.006681 | 2.175 |
| R-HSA-9839394 | TGFBR3 expression | 0.009271 | 2.033 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.013631 | 1.865 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 0.040340 | 1.394 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 0.040340 | 1.394 |
| R-HSA-5545619 | XAV939 stabilizes AXIN | 0.040340 | 1.394 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 0.040340 | 1.394 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 0.040340 | 1.394 |
| R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.040340 | 1.394 |
| R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.066329 | 1.178 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.066329 | 1.178 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.066329 | 1.178 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.079060 | 1.102 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.079060 | 1.102 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.079060 | 1.102 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.091618 | 1.038 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.091618 | 1.038 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.104005 | 0.983 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.104005 | 0.983 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.128277 | 0.892 |
| R-HSA-112412 | SOS-mediated signalling | 0.128277 | 0.892 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.128277 | 0.892 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.140167 | 0.853 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.140167 | 0.853 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.140167 | 0.853 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.151895 | 0.818 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.174876 | 0.757 |
| R-HSA-4839744 | Signaling by APC mutants | 0.174876 | 0.757 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.174876 | 0.757 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.174876 | 0.757 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.174876 | 0.757 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.186133 | 0.730 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.197237 | 0.705 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.197237 | 0.705 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.197237 | 0.705 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.197237 | 0.705 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.197237 | 0.705 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.197237 | 0.705 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.208190 | 0.682 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.088240 | 1.054 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.092403 | 1.034 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.092403 | 1.034 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.229652 | 0.639 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.229652 | 0.639 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.229652 | 0.639 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.100896 | 0.996 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.100896 | 0.996 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.105222 | 0.978 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.105222 | 0.978 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.240165 | 0.619 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.114018 | 0.943 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.250535 | 0.601 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.260764 | 0.584 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.132138 | 0.879 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.136766 | 0.864 |
| R-HSA-3371568 | Attenuation phase | 0.136766 | 0.864 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.280807 | 0.552 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.146127 | 0.835 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.290625 | 0.537 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.290625 | 0.537 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.309862 | 0.509 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.328579 | 0.483 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.194581 | 0.711 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.364512 | 0.438 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.364512 | 0.438 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.364512 | 0.438 |
| R-HSA-1989781 | PPARA activates gene expression | 0.091586 | 1.038 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.264927 | 0.577 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.290625 | 0.537 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.350283 | 0.456 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.208190 | 0.682 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.094986 | 1.022 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.088240 | 1.054 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.146127 | 0.835 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.163464 | 0.787 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.122996 | 0.910 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.146127 | 0.835 |
| R-HSA-3371556 | Cellular response to heat stress | 0.039650 | 1.402 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.118742 | 0.925 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.319284 | 0.496 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.219515 | 0.659 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.128158 | 0.892 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.128158 | 0.892 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.075249 | 1.123 |
| R-HSA-191650 | Regulation of gap junction activity | 0.079060 | 1.102 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.197237 | 0.705 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.305339 | 0.515 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.128158 | 0.892 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.027581 | 1.559 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.027581 | 1.559 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.197237 | 0.705 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.170058 | 0.769 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.170058 | 0.769 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.170058 | 0.769 |
| R-HSA-2424491 | DAP12 signaling | 0.088240 | 1.054 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.365059 | 0.438 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.091618 | 1.038 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.091618 | 1.038 |
| R-HSA-8849473 | PTK6 Expression | 0.128277 | 0.892 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.013817 | 1.860 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.151895 | 0.818 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.218994 | 0.660 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.122996 | 0.910 |
| R-HSA-69236 | G1 Phase | 0.160403 | 0.795 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.160403 | 0.795 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.071510 | 1.146 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.261222 | 0.583 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.214194 | 0.669 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.214194 | 0.669 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.096623 | 1.015 |
| R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA | 0.163464 | 0.787 |
| R-HSA-8851805 | MET activates RAS signaling | 0.197237 | 0.705 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.098715 | 1.006 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.133890 | 0.873 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.016756 | 1.776 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.355712 | 0.449 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.300302 | 0.522 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.116224 | 0.935 |
| R-HSA-74749 | Signal attenuation | 0.163464 | 0.787 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.186133 | 0.730 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.141430 | 0.849 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.295260 | 0.530 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.151895 | 0.818 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.170058 | 0.769 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.280807 | 0.552 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.364512 | 0.438 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.024696 | 1.607 |
| R-HSA-201451 | Signaling by BMP | 0.364512 | 0.438 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.089910 | 1.046 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.159408 | 0.797 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.079060 | 1.102 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.079060 | 1.102 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.091618 | 1.038 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.163464 | 0.787 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.174876 | 0.757 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.186133 | 0.730 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.186133 | 0.730 |
| R-HSA-428540 | Activation of RAC1 | 0.186133 | 0.730 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.186133 | 0.730 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.186133 | 0.730 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.208190 | 0.682 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.208190 | 0.682 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.208190 | 0.682 |
| R-HSA-1855191 | Synthesis of IPs in the nucleus | 0.218994 | 0.660 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.229652 | 0.639 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.240165 | 0.619 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.250535 | 0.601 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.122996 | 0.910 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.270854 | 0.567 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.270854 | 0.567 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.300309 | 0.522 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.165218 | 0.782 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.309862 | 0.509 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.309862 | 0.509 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.337748 | 0.471 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.364512 | 0.438 |
| R-HSA-6807070 | PTEN Regulation | 0.168360 | 0.774 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.290212 | 0.537 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.048747 | 1.312 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.229632 | 0.639 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.197237 | 0.705 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.109596 | 0.960 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.280807 | 0.552 |
| R-HSA-1181150 | Signaling by NODAL | 0.290625 | 0.537 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.146127 | 0.835 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.095975 | 1.018 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.186264 | 0.730 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.246583 | 0.608 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.151895 | 0.818 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.163464 | 0.787 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.197237 | 0.705 |
| R-HSA-1502540 | Signaling by Activin | 0.229652 | 0.639 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.105222 | 0.978 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.319284 | 0.496 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.214504 | 0.669 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.114018 | 0.943 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.034251 | 1.465 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.037260 | 1.429 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.021433 | 1.669 |
| R-HSA-2172127 | DAP12 interactions | 0.160403 | 0.795 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.061205 | 1.213 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.252318 | 0.598 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.100896 | 0.996 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.217748 | 0.662 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.196626 | 0.706 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.146127 | 0.835 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.163464 | 0.787 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.060871 | 1.216 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.060871 | 1.216 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.186133 | 0.730 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.218994 | 0.660 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.270854 | 0.567 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.364512 | 0.438 |
| R-HSA-191859 | snRNP Assembly | 0.234605 | 0.630 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.234605 | 0.630 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.244698 | 0.611 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.320406 | 0.494 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.268368 | 0.571 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.337748 | 0.471 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.355712 | 0.449 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.330407 | 0.481 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.357884 | 0.446 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.116224 | 0.935 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.028540 | 1.545 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.013817 | 1.860 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.197237 | 0.705 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.229652 | 0.639 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.229652 | 0.639 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.109596 | 0.960 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.072814 | 1.138 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.364512 | 0.438 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.029164 | 1.535 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.249752 | 0.602 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.063441 | 1.198 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.250535 | 0.601 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.270854 | 0.567 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.151895 | 0.818 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.197237 | 0.705 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.208190 | 0.682 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.208190 | 0.682 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.229652 | 0.639 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.240165 | 0.619 |
| R-HSA-9945266 | Differentiation of T cells | 0.240165 | 0.619 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.240165 | 0.619 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.136766 | 0.864 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.136766 | 0.864 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.141430 | 0.849 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.319284 | 0.496 |
| R-HSA-429947 | Deadenylation of mRNA | 0.337748 | 0.471 |
| R-HSA-165159 | MTOR signalling | 0.150856 | 0.821 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.241560 | 0.617 |
| R-HSA-157118 | Signaling by NOTCH | 0.286830 | 0.542 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.114018 | 0.943 |
| R-HSA-2262752 | Cellular responses to stress | 0.080571 | 1.094 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.229567 | 0.639 |
| R-HSA-186712 | Regulation of beta-cell development | 0.234605 | 0.630 |
| R-HSA-8939211 | ESR-mediated signaling | 0.144398 | 0.840 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.151895 | 0.818 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.050236 | 1.299 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.197237 | 0.705 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.260764 | 0.584 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.260764 | 0.584 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.280807 | 0.552 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.309862 | 0.509 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.319284 | 0.496 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.346791 | 0.460 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.039055 | 1.408 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.112873 | 0.947 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.042714 | 1.369 |
| R-HSA-210993 | Tie2 Signaling | 0.040366 | 1.394 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.023308 | 1.632 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.346791 | 0.460 |
| R-HSA-75153 | Apoptotic execution phase | 0.039055 | 1.408 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.316875 | 0.499 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.124892 | 0.903 |
| R-HSA-195721 | Signaling by WNT | 0.149961 | 0.824 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.091618 | 1.038 |
| R-HSA-9613354 | Lipophagy | 0.151895 | 0.818 |
| R-HSA-8949664 | Processing of SMDT1 | 0.208190 | 0.682 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.127547 | 0.894 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.270854 | 0.567 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.300309 | 0.522 |
| R-HSA-167044 | Signalling to RAS | 0.300309 | 0.522 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.170058 | 0.769 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.328579 | 0.483 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.328579 | 0.483 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.239649 | 0.620 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.123516 | 0.908 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.146835 | 0.833 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.116224 | 0.935 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.355712 | 0.449 |
| R-HSA-186763 | Downstream signal transduction | 0.092403 | 1.034 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.319284 | 0.496 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.337748 | 0.471 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.310369 | 0.508 |
| R-HSA-199991 | Membrane Trafficking | 0.133189 | 0.876 |
| R-HSA-449836 | Other interleukin signaling | 0.280807 | 0.552 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.257551 | 0.589 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.050580 | 1.296 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.300309 | 0.522 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.300309 | 0.522 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.239649 | 0.620 |
| R-HSA-5689877 | Josephin domain DUBs | 0.163464 | 0.787 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.012864 | 1.891 |
| R-HSA-354192 | Integrin signaling | 0.100896 | 0.996 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.250535 | 0.601 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.132138 | 0.879 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.098715 | 1.006 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.309862 | 0.509 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.328579 | 0.483 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.355712 | 0.449 |
| R-HSA-6806834 | Signaling by MET | 0.340368 | 0.468 |
| R-HSA-2559583 | Cellular Senescence | 0.292403 | 0.534 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.351309 | 0.454 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.224537 | 0.649 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.098661 | 1.006 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.165218 | 0.782 |
| R-HSA-4086398 | Ca2+ pathway | 0.305339 | 0.515 |
| R-HSA-210990 | PECAM1 interactions | 0.174876 | 0.757 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.219515 | 0.659 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.218994 | 0.660 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.270854 | 0.567 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.290799 | 0.536 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.218994 | 0.660 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.118485 | 0.926 |
| R-HSA-8853659 | RET signaling | 0.118485 | 0.926 |
| R-HSA-211000 | Gene Silencing by RNA | 0.224893 | 0.648 |
| R-HSA-177929 | Signaling by EGFR | 0.219515 | 0.659 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.100896 | 0.996 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.240165 | 0.619 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.300309 | 0.522 |
| R-HSA-3214842 | HDMs demethylate histones | 0.346791 | 0.460 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.075249 | 1.123 |
| R-HSA-8848021 | Signaling by PTK6 | 0.075249 | 1.123 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.197237 | 0.705 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.208190 | 0.682 |
| R-HSA-416700 | Other semaphorin interactions | 0.229652 | 0.639 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.355712 | 0.449 |
| R-HSA-211976 | Endogenous sterols | 0.244698 | 0.611 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.134392 | 0.872 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.309862 | 0.509 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.364512 | 0.438 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.140167 | 0.853 |
| R-HSA-9842663 | Signaling by LTK | 0.197237 | 0.705 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.309862 | 0.509 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.310369 | 0.508 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.135362 | 0.869 |
| R-HSA-166520 | Signaling by NTRKs | 0.195478 | 0.709 |
| R-HSA-186797 | Signaling by PDGF | 0.249752 | 0.602 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.355712 | 0.449 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.364512 | 0.438 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.277202 | 0.557 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.229652 | 0.639 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.280807 | 0.552 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 0.328579 | 0.483 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.355712 | 0.449 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.146127 | 0.835 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.199541 | 0.700 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.076110 | 1.119 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.240165 | 0.619 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.337748 | 0.471 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.201058 | 0.697 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.319284 | 0.496 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.275970 | 0.559 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.280807 | 0.552 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.319284 | 0.496 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.035564 | 1.449 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.075158 | 1.124 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.330407 | 0.481 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.315391 | 0.501 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.197237 | 0.705 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.305339 | 0.515 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.109596 | 0.960 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.328579 | 0.483 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.355712 | 0.449 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.096623 | 1.015 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.150856 | 0.821 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.136766 | 0.864 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.361602 | 0.442 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.355222 | 0.450 |
| R-HSA-2028269 | Signaling by Hippo | 0.260764 | 0.584 |
| R-HSA-9679506 | SARS-CoV Infections | 0.269195 | 0.570 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.275047 | 0.561 |
| R-HSA-1632852 | Macroautophagy | 0.369027 | 0.433 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.373192 | 0.428 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.373192 | 0.428 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.373192 | 0.428 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.373192 | 0.428 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.373192 | 0.428 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.373192 | 0.428 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.373192 | 0.428 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.374838 | 0.426 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.376438 | 0.424 |
| R-HSA-72086 | mRNA Capping | 0.381754 | 0.418 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.381754 | 0.418 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.381754 | 0.418 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.381754 | 0.418 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.381754 | 0.418 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.381754 | 0.418 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.381754 | 0.418 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.381754 | 0.418 |
| R-HSA-9663891 | Selective autophagy | 0.384557 | 0.415 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.390199 | 0.409 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.390199 | 0.409 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.390199 | 0.409 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.390199 | 0.409 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.390199 | 0.409 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.390199 | 0.409 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.390199 | 0.409 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.398530 | 0.400 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.398530 | 0.400 |
| R-HSA-182971 | EGFR downregulation | 0.398530 | 0.400 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.403793 | 0.394 |
| R-HSA-1538133 | G0 and Early G1 | 0.406747 | 0.391 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.406747 | 0.391 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.406747 | 0.391 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.413186 | 0.384 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.414852 | 0.382 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.414852 | 0.382 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.414852 | 0.382 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.414852 | 0.382 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.414852 | 0.382 |
| R-HSA-9733709 | Cardiogenesis | 0.414852 | 0.382 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.422848 | 0.374 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.422848 | 0.374 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.422848 | 0.374 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.424086 | 0.373 |
| R-HSA-9612973 | Autophagy | 0.427704 | 0.369 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.429458 | 0.367 |
| R-HSA-5673000 | RAF activation | 0.430734 | 0.366 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.430734 | 0.366 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.430734 | 0.366 |
| R-HSA-162587 | HIV Life Cycle | 0.431315 | 0.365 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.434637 | 0.362 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.436748 | 0.360 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.438513 | 0.358 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.438513 | 0.358 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.438513 | 0.358 |
| R-HSA-187687 | Signalling to ERKs | 0.438513 | 0.358 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.438513 | 0.358 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.442096 | 0.354 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.445984 | 0.351 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.445984 | 0.351 |
| R-HSA-3371511 | HSF1 activation | 0.446187 | 0.350 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.446187 | 0.350 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.446187 | 0.350 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.446187 | 0.350 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.446187 | 0.350 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.446187 | 0.350 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.446187 | 0.350 |
| R-HSA-109581 | Apoptosis | 0.449240 | 0.348 |
| R-HSA-70171 | Glycolysis | 0.450570 | 0.346 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.453756 | 0.343 |
| R-HSA-4641257 | Degradation of AXIN | 0.453756 | 0.343 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.453756 | 0.343 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.453756 | 0.343 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.459678 | 0.338 |
| R-HSA-1483255 | PI Metabolism | 0.459678 | 0.338 |
| R-HSA-8875878 | MET promotes cell motility | 0.461222 | 0.336 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.468586 | 0.329 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.468586 | 0.329 |
| R-HSA-201556 | Signaling by ALK | 0.468586 | 0.329 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.468698 | 0.329 |
| R-HSA-9833110 | RSV-host interactions | 0.473175 | 0.325 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.475850 | 0.323 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.475850 | 0.323 |
| R-HSA-167169 | HIV Transcription Elongation | 0.475850 | 0.323 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.475850 | 0.323 |
| R-HSA-202433 | Generation of second messenger molecules | 0.475850 | 0.323 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.475850 | 0.323 |
| R-HSA-9646399 | Aggrephagy | 0.475850 | 0.323 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.475850 | 0.323 |
| R-HSA-72306 | tRNA processing | 0.480910 | 0.318 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.482059 | 0.317 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.483016 | 0.316 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.483016 | 0.316 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.483016 | 0.316 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.483016 | 0.316 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.483016 | 0.316 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.487833 | 0.312 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.490084 | 0.310 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.490084 | 0.310 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.497055 | 0.304 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.498134 | 0.303 |
| R-HSA-202403 | TCR signaling | 0.499550 | 0.301 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.499550 | 0.301 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.503932 | 0.298 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.503932 | 0.298 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.503932 | 0.298 |
| R-HSA-8854214 | TBC/RABGAPs | 0.503932 | 0.298 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.508153 | 0.294 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.510715 | 0.292 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.510715 | 0.292 |
| R-HSA-168255 | Influenza Infection | 0.511706 | 0.291 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.517406 | 0.286 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.517406 | 0.286 |
| R-HSA-437239 | Recycling pathway of L1 | 0.530516 | 0.275 |
| R-HSA-373760 | L1CAM interactions | 0.533380 | 0.273 |
| R-HSA-70326 | Glucose metabolism | 0.537498 | 0.270 |
| R-HSA-5693538 | Homology Directed Repair | 0.541591 | 0.266 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.543271 | 0.265 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.543271 | 0.265 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.543271 | 0.265 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.543271 | 0.265 |
| R-HSA-73893 | DNA Damage Bypass | 0.543271 | 0.265 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.543271 | 0.265 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.549518 | 0.260 |
| R-HSA-68875 | Mitotic Prophase | 0.549702 | 0.260 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.555845 | 0.255 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.561759 | 0.250 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.561759 | 0.250 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.565621 | 0.247 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.567755 | 0.246 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.567755 | 0.246 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.567755 | 0.246 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.567755 | 0.246 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.567755 | 0.246 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.567755 | 0.246 |
| R-HSA-69206 | G1/S Transition | 0.573428 | 0.242 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.579503 | 0.237 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.579601 | 0.237 |
| R-HSA-162582 | Signal Transduction | 0.584679 | 0.233 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.585257 | 0.233 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.585257 | 0.233 |
| R-HSA-9675108 | Nervous system development | 0.588091 | 0.231 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.588807 | 0.230 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.588807 | 0.230 |
| R-HSA-112399 | IRS-mediated signalling | 0.590932 | 0.228 |
| R-HSA-5357801 | Programmed Cell Death | 0.597884 | 0.223 |
| R-HSA-73894 | DNA Repair | 0.598851 | 0.223 |
| R-HSA-180786 | Extension of Telomeres | 0.602053 | 0.220 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.602053 | 0.220 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.607500 | 0.216 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.607500 | 0.216 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.607500 | 0.216 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.607500 | 0.216 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.607500 | 0.216 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.607500 | 0.216 |
| R-HSA-983189 | Kinesins | 0.607500 | 0.216 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.612872 | 0.213 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.612872 | 0.213 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.612872 | 0.213 |
| R-HSA-450294 | MAP kinase activation | 0.612872 | 0.213 |
| R-HSA-1442490 | Collagen degradation | 0.612872 | 0.213 |
| R-HSA-1268020 | Mitochondrial protein import | 0.618172 | 0.209 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.618172 | 0.209 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.618172 | 0.209 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.618172 | 0.209 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.621445 | 0.207 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.621682 | 0.206 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.623399 | 0.205 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.623399 | 0.205 |
| R-HSA-373755 | Semaphorin interactions | 0.623399 | 0.205 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.625215 | 0.204 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.628555 | 0.202 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.628555 | 0.202 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.633641 | 0.198 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.633641 | 0.198 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.638657 | 0.195 |
| R-HSA-196807 | Nicotinate metabolism | 0.643605 | 0.191 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.644229 | 0.191 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.645879 | 0.190 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.646298 | 0.190 |
| R-HSA-167172 | Transcription of the HIV genome | 0.648486 | 0.188 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.648486 | 0.188 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.648486 | 0.188 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.658048 | 0.182 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.658048 | 0.182 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.658048 | 0.182 |
| R-HSA-448424 | Interleukin-17 signaling | 0.658048 | 0.182 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.658048 | 0.182 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.658048 | 0.182 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.659150 | 0.181 |
| R-HSA-162906 | HIV Infection | 0.660382 | 0.180 |
| R-HSA-422475 | Axon guidance | 0.661552 | 0.179 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.662405 | 0.179 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.662732 | 0.179 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.662732 | 0.179 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.663050 | 0.178 |
| R-HSA-69242 | S Phase | 0.665635 | 0.177 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.667351 | 0.176 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.667351 | 0.176 |
| R-HSA-9758941 | Gastrulation | 0.668841 | 0.175 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.671908 | 0.173 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.672021 | 0.173 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.676403 | 0.170 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.676403 | 0.170 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.680836 | 0.167 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.681416 | 0.167 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.684498 | 0.165 |
| R-HSA-73887 | Death Receptor Signaling | 0.684498 | 0.165 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.685209 | 0.164 |
| R-HSA-5689603 | UCH proteinases | 0.685209 | 0.164 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.686383 | 0.163 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.689522 | 0.161 |
| R-HSA-9610379 | HCMV Late Events | 0.693599 | 0.159 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.693776 | 0.159 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.693776 | 0.159 |
| R-HSA-9711097 | Cellular response to starvation | 0.696585 | 0.157 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.696585 | 0.157 |
| R-HSA-9659379 | Sensory processing of sound | 0.697973 | 0.156 |
| R-HSA-877300 | Interferon gamma signaling | 0.699546 | 0.155 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.702112 | 0.154 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.702112 | 0.154 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.702112 | 0.154 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.702112 | 0.154 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.706195 | 0.151 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.710221 | 0.149 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.721975 | 0.141 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.722387 | 0.141 |
| R-HSA-5619102 | SLC transporter disorders | 0.722387 | 0.141 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.725787 | 0.139 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.725787 | 0.139 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.725787 | 0.139 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.729547 | 0.137 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.729547 | 0.137 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.731646 | 0.136 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.733255 | 0.135 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.733255 | 0.135 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.735909 | 0.133 |
| R-HSA-156902 | Peptide chain elongation | 0.736912 | 0.133 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.744079 | 0.128 |
| R-HSA-73884 | Base Excision Repair | 0.744079 | 0.128 |
| R-HSA-202424 | Downstream TCR signaling | 0.744079 | 0.128 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.747142 | 0.127 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.747588 | 0.126 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.747588 | 0.126 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.751050 | 0.124 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.754465 | 0.122 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.754465 | 0.122 |
| R-HSA-391251 | Protein folding | 0.754465 | 0.122 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.754465 | 0.122 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.757502 | 0.121 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.757833 | 0.120 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.761155 | 0.119 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.764432 | 0.117 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.764432 | 0.117 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.767664 | 0.115 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.767664 | 0.115 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.767664 | 0.115 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.769661 | 0.114 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.770851 | 0.113 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.770851 | 0.113 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.770851 | 0.113 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.770851 | 0.113 |
| R-HSA-157579 | Telomere Maintenance | 0.773996 | 0.111 |
| R-HSA-190236 | Signaling by FGFR | 0.777097 | 0.110 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.777097 | 0.110 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.777097 | 0.110 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.777097 | 0.110 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.777766 | 0.109 |
| R-HSA-109582 | Hemostasis | 0.779084 | 0.108 |
| R-HSA-597592 | Post-translational protein modification | 0.779786 | 0.108 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.783173 | 0.106 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.783173 | 0.106 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.786149 | 0.104 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.786149 | 0.104 |
| R-HSA-449147 | Signaling by Interleukins | 0.786294 | 0.104 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.789084 | 0.103 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.789084 | 0.103 |
| R-HSA-192823 | Viral mRNA Translation | 0.791979 | 0.101 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.794835 | 0.100 |
| R-HSA-9609690 | HCMV Early Events | 0.795384 | 0.099 |
| R-HSA-9824446 | Viral Infection Pathways | 0.799927 | 0.097 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.800429 | 0.097 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.803724 | 0.095 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.805872 | 0.094 |
| R-HSA-913531 | Interferon Signaling | 0.806878 | 0.093 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.807780 | 0.093 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.808538 | 0.092 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.808538 | 0.092 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.808538 | 0.092 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.808538 | 0.092 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.811167 | 0.091 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.811167 | 0.091 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.813760 | 0.090 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.813760 | 0.090 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.818841 | 0.087 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.818841 | 0.087 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.818916 | 0.087 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.821329 | 0.085 |
| R-HSA-1266738 | Developmental Biology | 0.821991 | 0.085 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.823784 | 0.084 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.823784 | 0.084 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.828592 | 0.082 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.830947 | 0.080 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.833270 | 0.079 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.833270 | 0.079 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.835561 | 0.078 |
| R-HSA-68882 | Mitotic Anaphase | 0.835897 | 0.078 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.837634 | 0.077 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.837821 | 0.077 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.840050 | 0.076 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.840050 | 0.076 |
| R-HSA-8951664 | Neddylation | 0.844414 | 0.073 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.844416 | 0.073 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.844416 | 0.073 |
| R-HSA-73886 | Chromosome Maintenance | 0.844416 | 0.073 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.846555 | 0.072 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.846555 | 0.072 |
| R-HSA-8957322 | Metabolism of steroids | 0.852709 | 0.069 |
| R-HSA-194138 | Signaling by VEGF | 0.854820 | 0.068 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.858744 | 0.066 |
| R-HSA-72312 | rRNA processing | 0.861760 | 0.065 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.870045 | 0.060 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.870045 | 0.060 |
| R-HSA-1640170 | Cell Cycle | 0.875948 | 0.058 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.882056 | 0.055 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.882576 | 0.054 |
| R-HSA-9609646 | HCMV Infection | 0.886376 | 0.052 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.895963 | 0.048 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.898737 | 0.046 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.902864 | 0.044 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.904202 | 0.044 |
| R-HSA-8953854 | Metabolism of RNA | 0.905072 | 0.043 |
| R-HSA-9609507 | Protein localization | 0.905521 | 0.043 |
| R-HSA-68886 | M Phase | 0.916196 | 0.038 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.916744 | 0.038 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.917674 | 0.037 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.918896 | 0.037 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.918896 | 0.037 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.920405 | 0.036 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.926407 | 0.033 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.929410 | 0.032 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.929410 | 0.032 |
| R-HSA-1483257 | Phospholipid metabolism | 0.931287 | 0.031 |
| R-HSA-69275 | G2/M Transition | 0.941076 | 0.026 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.942692 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.943872 | 0.025 |
| R-HSA-5617833 | Cilium Assembly | 0.944264 | 0.025 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.945033 | 0.025 |
| R-HSA-68877 | Mitotic Prometaphase | 0.946541 | 0.024 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.948726 | 0.023 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.950148 | 0.022 |
| R-HSA-397014 | Muscle contraction | 0.959529 | 0.018 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.959529 | 0.018 |
| R-HSA-1280218 | Adaptive Immune System | 0.960041 | 0.018 |
| R-HSA-418990 | Adherens junctions interactions | 0.962773 | 0.016 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.969125 | 0.014 |
| R-HSA-15869 | Metabolism of nucleotides | 0.971033 | 0.013 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.975647 | 0.011 |
| R-HSA-421270 | Cell-cell junction organization | 0.976503 | 0.010 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.980128 | 0.009 |
| R-HSA-416476 | G alpha (q) signalling events | 0.980404 | 0.009 |
| R-HSA-392499 | Metabolism of proteins | 0.983086 | 0.007 |
| R-HSA-446728 | Cell junction organization | 0.983887 | 0.007 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.989805 | 0.004 |
| R-HSA-6798695 | Neutrophil degranulation | 0.990052 | 0.004 |
| R-HSA-1500931 | Cell-Cell communication | 0.990535 | 0.004 |
| R-HSA-112316 | Neuronal System | 0.991310 | 0.004 |
| R-HSA-1474244 | Extracellular matrix organization | 0.992330 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.995031 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.995611 | 0.002 |
| R-HSA-168256 | Immune System | 0.997267 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.997403 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998041 | 0.001 |
| R-HSA-72766 | Translation | 0.998096 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.999511 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999700 | 0.000 |
| R-HSA-1643685 | Disease | 0.999795 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999828 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999870 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999943 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999989 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.820 | 0.608 | 1 | 0.833 |
HIPK2 |
0.814 | 0.636 | 1 | 0.869 |
CDK18 |
0.811 | 0.658 | 1 | 0.891 |
P38G |
0.809 | 0.672 | 1 | 0.923 |
CDK17 |
0.807 | 0.663 | 1 | 0.913 |
CDK1 |
0.806 | 0.645 | 1 | 0.874 |
JNK2 |
0.805 | 0.682 | 1 | 0.896 |
CDK19 |
0.805 | 0.635 | 1 | 0.880 |
ERK1 |
0.804 | 0.659 | 1 | 0.881 |
CDK3 |
0.803 | 0.585 | 1 | 0.909 |
P38B |
0.801 | 0.669 | 1 | 0.867 |
P38D |
0.801 | 0.655 | 1 | 0.923 |
CDK8 |
0.800 | 0.632 | 1 | 0.850 |
CDK7 |
0.799 | 0.639 | 1 | 0.856 |
CDK16 |
0.797 | 0.625 | 1 | 0.902 |
JNK3 |
0.796 | 0.668 | 1 | 0.872 |
CDK5 |
0.796 | 0.630 | 1 | 0.829 |
DYRK2 |
0.796 | 0.595 | 1 | 0.798 |
CDK13 |
0.795 | 0.628 | 1 | 0.875 |
CDK12 |
0.793 | 0.624 | 1 | 0.892 |
DYRK4 |
0.791 | 0.597 | 1 | 0.883 |
CDK10 |
0.791 | 0.589 | 1 | 0.871 |
CLK3 |
0.789 | 0.433 | 1 | 0.579 |
CDK14 |
0.789 | 0.619 | 1 | 0.859 |
HIPK1 |
0.789 | 0.552 | 1 | 0.783 |
P38A |
0.788 | 0.637 | 1 | 0.806 |
HIPK4 |
0.787 | 0.466 | 1 | 0.598 |
CDK9 |
0.784 | 0.609 | 1 | 0.871 |
ERK2 |
0.782 | 0.624 | 1 | 0.838 |
JNK1 |
0.781 | 0.600 | 1 | 0.893 |
HIPK3 |
0.778 | 0.536 | 1 | 0.756 |
NLK |
0.778 | 0.562 | 1 | 0.619 |
DYRK1B |
0.778 | 0.552 | 1 | 0.842 |
SRPK1 |
0.777 | 0.295 | -3 | 0.741 |
DYRK1A |
0.776 | 0.492 | 1 | 0.769 |
CDK6 |
0.775 | 0.597 | 1 | 0.874 |
CDK4 |
0.775 | 0.614 | 1 | 0.896 |
MAK |
0.772 | 0.469 | -2 | 0.865 |
ERK5 |
0.768 | 0.341 | 1 | 0.537 |
SRPK2 |
0.767 | 0.255 | -3 | 0.663 |
CDK2 |
0.766 | 0.454 | 1 | 0.765 |
DYRK3 |
0.765 | 0.423 | 1 | 0.745 |
CLK2 |
0.763 | 0.324 | -3 | 0.718 |
ICK |
0.762 | 0.345 | -3 | 0.798 |
CDKL5 |
0.761 | 0.195 | -3 | 0.766 |
MTOR |
0.758 | 0.174 | 1 | 0.428 |
CLK1 |
0.758 | 0.303 | -3 | 0.710 |
CLK4 |
0.755 | 0.282 | -3 | 0.727 |
COT |
0.755 | 0.005 | 2 | 0.848 |
CDKL1 |
0.754 | 0.161 | -3 | 0.775 |
SRPK3 |
0.754 | 0.200 | -3 | 0.715 |
MOK |
0.752 | 0.390 | 1 | 0.673 |
MOS |
0.751 | 0.087 | 1 | 0.296 |
PRP4 |
0.750 | 0.359 | -3 | 0.740 |
CDC7 |
0.743 | -0.048 | 1 | 0.256 |
GRK1 |
0.743 | 0.109 | -2 | 0.837 |
ERK7 |
0.742 | 0.242 | 2 | 0.597 |
PRPK |
0.741 | -0.015 | -1 | 0.833 |
PIM3 |
0.741 | 0.015 | -3 | 0.791 |
ATR |
0.741 | -0.015 | 1 | 0.289 |
TBK1 |
0.740 | -0.086 | 1 | 0.227 |
NDR2 |
0.740 | 0.045 | -3 | 0.782 |
IKKB |
0.739 | -0.081 | -2 | 0.728 |
MST4 |
0.737 | -0.021 | 2 | 0.862 |
CHAK2 |
0.737 | 0.022 | -1 | 0.823 |
GRK7 |
0.736 | 0.102 | 1 | 0.267 |
NEK6 |
0.736 | -0.010 | -2 | 0.816 |
RAF1 |
0.736 | -0.150 | 1 | 0.251 |
DSTYK |
0.735 | -0.099 | 2 | 0.868 |
IKKE |
0.735 | -0.105 | 1 | 0.226 |
SKMLCK |
0.734 | 0.021 | -2 | 0.854 |
BMPR2 |
0.733 | -0.080 | -2 | 0.860 |
WNK1 |
0.733 | -0.065 | -2 | 0.857 |
PDHK4 |
0.732 | -0.139 | 1 | 0.313 |
MLK1 |
0.732 | -0.061 | 2 | 0.815 |
MLK3 |
0.731 | 0.043 | 2 | 0.753 |
GCN2 |
0.731 | -0.158 | 2 | 0.768 |
AURC |
0.731 | 0.046 | -2 | 0.651 |
PKN3 |
0.730 | -0.032 | -3 | 0.774 |
CAMK1B |
0.730 | -0.053 | -3 | 0.808 |
TGFBR2 |
0.730 | -0.051 | -2 | 0.793 |
RIPK3 |
0.730 | -0.085 | 3 | 0.750 |
NUAK2 |
0.730 | -0.011 | -3 | 0.787 |
NIK |
0.729 | -0.047 | -3 | 0.818 |
ULK2 |
0.729 | -0.121 | 2 | 0.757 |
PKN2 |
0.729 | -0.049 | -3 | 0.795 |
MLK2 |
0.729 | 0.030 | 2 | 0.803 |
BMPR1B |
0.728 | -0.011 | 1 | 0.225 |
CAMLCK |
0.728 | -0.005 | -2 | 0.833 |
PKCD |
0.727 | 0.001 | 2 | 0.787 |
NEK7 |
0.727 | -0.123 | -3 | 0.784 |
IKKA |
0.727 | -0.021 | -2 | 0.726 |
NDR1 |
0.727 | -0.045 | -3 | 0.777 |
GRK5 |
0.726 | -0.090 | -3 | 0.801 |
DAPK2 |
0.726 | -0.020 | -3 | 0.809 |
PRKD1 |
0.725 | -0.042 | -3 | 0.788 |
IRE1 |
0.725 | -0.052 | 1 | 0.229 |
PDHK1 |
0.725 | -0.138 | 1 | 0.292 |
RSK2 |
0.725 | -0.015 | -3 | 0.736 |
PIM1 |
0.724 | 0.006 | -3 | 0.748 |
CAMK2G |
0.724 | -0.100 | 2 | 0.757 |
PKCA |
0.723 | 0.027 | 2 | 0.744 |
RSK3 |
0.723 | -0.020 | -3 | 0.733 |
MPSK1 |
0.723 | 0.111 | 1 | 0.295 |
P90RSK |
0.722 | -0.012 | -3 | 0.736 |
PHKG1 |
0.722 | -0.023 | -3 | 0.771 |
PKCB |
0.722 | 0.002 | 2 | 0.752 |
PRKD2 |
0.721 | -0.036 | -3 | 0.738 |
PKACG |
0.721 | -0.028 | -2 | 0.723 |
MNK2 |
0.721 | 0.005 | -2 | 0.757 |
ULK1 |
0.721 | -0.111 | -3 | 0.748 |
AMPKA1 |
0.720 | -0.054 | -3 | 0.797 |
PKCG |
0.720 | -0.012 | 2 | 0.746 |
DLK |
0.720 | -0.111 | 1 | 0.257 |
PKCZ |
0.720 | 0.010 | 2 | 0.779 |
P70S6KB |
0.720 | -0.024 | -3 | 0.750 |
ALK4 |
0.719 | -0.034 | -2 | 0.828 |
NEK9 |
0.719 | -0.107 | 2 | 0.822 |
WNK3 |
0.719 | -0.170 | 1 | 0.243 |
MARK4 |
0.719 | -0.069 | 4 | 0.811 |
PINK1 |
0.718 | 0.101 | 1 | 0.436 |
LATS2 |
0.718 | -0.031 | -5 | 0.697 |
GSK3A |
0.718 | 0.153 | 4 | 0.411 |
LATS1 |
0.718 | 0.021 | -3 | 0.774 |
BCKDK |
0.717 | -0.122 | -1 | 0.722 |
SMG1 |
0.717 | -0.042 | 1 | 0.271 |
MASTL |
0.717 | -0.135 | -2 | 0.794 |
TGFBR1 |
0.717 | -0.028 | -2 | 0.804 |
YSK4 |
0.717 | -0.082 | 1 | 0.233 |
ANKRD3 |
0.717 | -0.132 | 1 | 0.260 |
CK1E |
0.717 | 0.004 | -3 | 0.543 |
CAMK2D |
0.716 | -0.080 | -3 | 0.787 |
PAK1 |
0.716 | -0.024 | -2 | 0.791 |
AMPKA2 |
0.716 | -0.033 | -3 | 0.770 |
TTBK2 |
0.716 | -0.136 | 2 | 0.670 |
AKT2 |
0.716 | 0.025 | -3 | 0.668 |
VRK2 |
0.716 | 0.081 | 1 | 0.342 |
RIPK1 |
0.716 | -0.139 | 1 | 0.228 |
MAPKAPK3 |
0.716 | -0.075 | -3 | 0.736 |
MLK4 |
0.716 | -0.037 | 2 | 0.725 |
ATM |
0.715 | -0.073 | 1 | 0.251 |
RSK4 |
0.715 | 0.017 | -3 | 0.702 |
PAK3 |
0.715 | -0.043 | -2 | 0.776 |
HUNK |
0.715 | -0.162 | 2 | 0.774 |
PKR |
0.715 | -0.063 | 1 | 0.255 |
MNK1 |
0.715 | -0.010 | -2 | 0.767 |
IRE2 |
0.714 | -0.062 | 2 | 0.746 |
PKACB |
0.714 | 0.013 | -2 | 0.657 |
PRKD3 |
0.714 | -0.038 | -3 | 0.722 |
MST3 |
0.714 | -0.009 | 2 | 0.848 |
PKG2 |
0.714 | -0.003 | -2 | 0.657 |
SGK3 |
0.713 | -0.003 | -3 | 0.732 |
GRK6 |
0.713 | -0.124 | 1 | 0.242 |
ACVR2B |
0.713 | -0.059 | -2 | 0.795 |
MAPKAPK2 |
0.713 | -0.042 | -3 | 0.700 |
PAK6 |
0.713 | -0.012 | -2 | 0.694 |
PKCH |
0.713 | -0.035 | 2 | 0.730 |
DNAPK |
0.712 | -0.046 | 1 | 0.277 |
CK1D |
0.712 | 0.017 | -3 | 0.501 |
ACVR2A |
0.711 | -0.071 | -2 | 0.783 |
GRK4 |
0.711 | -0.125 | -2 | 0.841 |
AURB |
0.711 | -0.016 | -2 | 0.646 |
MSK2 |
0.709 | -0.038 | -3 | 0.723 |
MELK |
0.709 | -0.068 | -3 | 0.752 |
CAMK2A |
0.709 | -0.017 | 2 | 0.744 |
NEK2 |
0.709 | -0.099 | 2 | 0.808 |
MYLK4 |
0.709 | -0.040 | -2 | 0.761 |
NUAK1 |
0.709 | -0.054 | -3 | 0.732 |
TAO3 |
0.708 | 0.004 | 1 | 0.274 |
PIM2 |
0.708 | -0.002 | -3 | 0.712 |
MEK1 |
0.708 | -0.137 | 2 | 0.804 |
TSSK1 |
0.708 | -0.099 | -3 | 0.809 |
CHAK1 |
0.708 | -0.111 | 2 | 0.744 |
TLK2 |
0.707 | -0.078 | 1 | 0.222 |
NIM1 |
0.707 | -0.107 | 3 | 0.765 |
GRK2 |
0.707 | -0.064 | -2 | 0.739 |
QSK |
0.707 | -0.045 | 4 | 0.794 |
ALK2 |
0.707 | -0.063 | -2 | 0.812 |
PRKX |
0.707 | 0.017 | -3 | 0.646 |
MEKK3 |
0.707 | -0.108 | 1 | 0.250 |
MSK1 |
0.707 | -0.016 | -3 | 0.725 |
PLK1 |
0.706 | -0.124 | -2 | 0.765 |
FAM20C |
0.706 | -0.027 | 2 | 0.579 |
CAMK4 |
0.706 | -0.130 | -3 | 0.757 |
PAK2 |
0.706 | -0.062 | -2 | 0.774 |
TSSK2 |
0.706 | -0.151 | -5 | 0.789 |
QIK |
0.705 | -0.119 | -3 | 0.774 |
MEKK2 |
0.705 | -0.065 | 2 | 0.784 |
BMPR1A |
0.705 | -0.049 | 1 | 0.213 |
MEK5 |
0.705 | -0.106 | 2 | 0.798 |
PASK |
0.705 | -0.001 | -3 | 0.808 |
DRAK1 |
0.705 | -0.103 | 1 | 0.213 |
ZAK |
0.704 | -0.103 | 1 | 0.239 |
AKT1 |
0.703 | 0.001 | -3 | 0.681 |
BRSK2 |
0.703 | -0.053 | -3 | 0.757 |
CAMK2B |
0.703 | -0.072 | 2 | 0.722 |
PLK4 |
0.703 | -0.085 | 2 | 0.580 |
CK1A2 |
0.703 | -0.013 | -3 | 0.503 |
PKCT |
0.703 | -0.033 | 2 | 0.734 |
SIK |
0.702 | -0.057 | -3 | 0.716 |
AURA |
0.702 | -0.028 | -2 | 0.627 |
PERK |
0.702 | -0.112 | -2 | 0.820 |
NEK5 |
0.702 | -0.073 | 1 | 0.238 |
CK1G1 |
0.702 | -0.043 | -3 | 0.535 |
PKCE |
0.702 | 0.004 | 2 | 0.739 |
GSK3B |
0.701 | 0.033 | 4 | 0.408 |
WNK4 |
0.701 | -0.120 | -2 | 0.845 |
BRAF |
0.701 | -0.101 | -4 | 0.362 |
IRAK4 |
0.701 | -0.084 | 1 | 0.215 |
PKCI |
0.701 | -0.028 | 2 | 0.760 |
MEKK1 |
0.700 | -0.122 | 1 | 0.251 |
HRI |
0.700 | -0.146 | -2 | 0.829 |
DCAMKL1 |
0.700 | -0.050 | -3 | 0.740 |
NEK11 |
0.700 | -0.071 | 1 | 0.270 |
BRSK1 |
0.700 | -0.050 | -3 | 0.747 |
PDK1 |
0.700 | -0.025 | 1 | 0.278 |
GCK |
0.699 | -0.003 | 1 | 0.257 |
MARK3 |
0.699 | -0.059 | 4 | 0.752 |
LKB1 |
0.698 | 0.002 | -3 | 0.767 |
MAPKAPK5 |
0.698 | -0.097 | -3 | 0.689 |
MAP3K15 |
0.698 | -0.012 | 1 | 0.251 |
PHKG2 |
0.698 | -0.090 | -3 | 0.746 |
AKT3 |
0.698 | 0.024 | -3 | 0.623 |
NEK8 |
0.697 | -0.094 | 2 | 0.811 |
BUB1 |
0.697 | 0.046 | -5 | 0.726 |
GAK |
0.697 | -0.047 | 1 | 0.298 |
CAMK1G |
0.696 | -0.084 | -3 | 0.721 |
TLK1 |
0.696 | -0.144 | -2 | 0.825 |
SMMLCK |
0.696 | -0.055 | -3 | 0.776 |
GRK3 |
0.696 | -0.061 | -2 | 0.708 |
TAO2 |
0.696 | -0.047 | 2 | 0.835 |
HPK1 |
0.696 | -0.034 | 1 | 0.258 |
PKACA |
0.695 | -0.009 | -2 | 0.609 |
SNRK |
0.695 | -0.147 | 2 | 0.649 |
MEKK6 |
0.695 | -0.072 | 1 | 0.255 |
TNIK |
0.694 | -0.008 | 3 | 0.886 |
PAK5 |
0.694 | -0.038 | -2 | 0.649 |
HGK |
0.693 | -0.043 | 3 | 0.883 |
SSTK |
0.693 | -0.087 | 4 | 0.789 |
P70S6K |
0.692 | -0.046 | -3 | 0.677 |
KHS1 |
0.692 | -0.002 | 1 | 0.250 |
MARK2 |
0.692 | -0.088 | 4 | 0.715 |
PKN1 |
0.691 | -0.039 | -3 | 0.691 |
KHS2 |
0.691 | 0.006 | 1 | 0.262 |
EEF2K |
0.691 | -0.040 | 3 | 0.842 |
MINK |
0.691 | -0.073 | 1 | 0.234 |
TTBK1 |
0.691 | -0.133 | 2 | 0.586 |
HASPIN |
0.691 | 0.021 | -1 | 0.681 |
PBK |
0.691 | -0.006 | 1 | 0.273 |
SGK1 |
0.691 | 0.025 | -3 | 0.602 |
DCAMKL2 |
0.691 | -0.068 | -3 | 0.752 |
PLK3 |
0.690 | -0.142 | 2 | 0.716 |
PAK4 |
0.690 | -0.030 | -2 | 0.656 |
SLK |
0.690 | -0.001 | -2 | 0.702 |
MST2 |
0.690 | -0.100 | 1 | 0.242 |
LOK |
0.689 | -0.035 | -2 | 0.733 |
LRRK2 |
0.689 | -0.009 | 2 | 0.830 |
NEK4 |
0.688 | -0.116 | 1 | 0.227 |
MRCKB |
0.688 | -0.010 | -3 | 0.704 |
CHK1 |
0.688 | -0.140 | -3 | 0.743 |
DAPK3 |
0.688 | -0.044 | -3 | 0.755 |
ROCK2 |
0.688 | 0.001 | -3 | 0.740 |
TAK1 |
0.687 | -0.117 | 1 | 0.233 |
MARK1 |
0.687 | -0.110 | 4 | 0.767 |
CAMKK2 |
0.686 | -0.111 | -2 | 0.712 |
CAMKK1 |
0.685 | -0.156 | -2 | 0.710 |
CK2A2 |
0.685 | -0.064 | 1 | 0.198 |
NEK1 |
0.683 | -0.092 | 1 | 0.221 |
DAPK1 |
0.683 | -0.047 | -3 | 0.747 |
MRCKA |
0.682 | -0.023 | -3 | 0.705 |
SBK |
0.682 | 0.044 | -3 | 0.565 |
YSK1 |
0.682 | -0.081 | 2 | 0.811 |
CHK2 |
0.681 | -0.041 | -3 | 0.621 |
VRK1 |
0.680 | -0.119 | 2 | 0.815 |
OSR1 |
0.679 | -0.032 | 2 | 0.788 |
MST1 |
0.679 | -0.138 | 1 | 0.231 |
DMPK1 |
0.678 | -0.002 | -3 | 0.726 |
CK1A |
0.678 | -0.024 | -3 | 0.420 |
PDHK3_TYR |
0.678 | 0.111 | 4 | 0.848 |
CAMK1D |
0.677 | -0.074 | -3 | 0.645 |
CK2A1 |
0.677 | -0.067 | 1 | 0.189 |
STK33 |
0.677 | -0.105 | 2 | 0.578 |
IRAK1 |
0.675 | -0.230 | -1 | 0.707 |
LIMK2_TYR |
0.675 | 0.126 | -3 | 0.823 |
RIPK2 |
0.674 | -0.188 | 1 | 0.218 |
CAMK1A |
0.674 | -0.053 | -3 | 0.647 |
TESK1_TYR |
0.673 | 0.065 | 3 | 0.877 |
BIKE |
0.673 | -0.028 | 1 | 0.280 |
ROCK1 |
0.673 | -0.025 | -3 | 0.711 |
CRIK |
0.672 | -0.002 | -3 | 0.684 |
PDHK4_TYR |
0.672 | 0.059 | 2 | 0.839 |
MAP2K4_TYR |
0.672 | 0.045 | -1 | 0.844 |
PKMYT1_TYR |
0.671 | 0.096 | 3 | 0.849 |
NEK3 |
0.671 | -0.126 | 1 | 0.247 |
BMPR2_TYR |
0.671 | 0.027 | -1 | 0.862 |
MEK2 |
0.671 | -0.168 | 2 | 0.771 |
ASK1 |
0.671 | -0.066 | 1 | 0.251 |
MAP2K6_TYR |
0.670 | 0.054 | -1 | 0.852 |
MYO3B |
0.670 | -0.050 | 2 | 0.822 |
PKG1 |
0.670 | -0.047 | -2 | 0.570 |
TTK |
0.669 | -0.071 | -2 | 0.804 |
PDHK1_TYR |
0.669 | -0.005 | -1 | 0.870 |
MYO3A |
0.668 | -0.067 | 1 | 0.242 |
AAK1 |
0.668 | 0.001 | 1 | 0.276 |
MAP2K7_TYR |
0.668 | -0.025 | 2 | 0.819 |
TAO1 |
0.667 | -0.067 | 1 | 0.239 |
PLK2 |
0.666 | -0.098 | -3 | 0.692 |
ALPHAK3 |
0.665 | -0.061 | -1 | 0.767 |
PINK1_TYR |
0.664 | -0.119 | 1 | 0.297 |
MST1R |
0.662 | -0.034 | 3 | 0.821 |
RET |
0.662 | -0.063 | 1 | 0.266 |
EPHA6 |
0.662 | -0.026 | -1 | 0.851 |
CSF1R |
0.661 | -0.014 | 3 | 0.805 |
TXK |
0.660 | -0.002 | 1 | 0.227 |
LIMK1_TYR |
0.660 | -0.014 | 2 | 0.821 |
JAK2 |
0.660 | -0.061 | 1 | 0.277 |
ABL2 |
0.659 | -0.031 | -1 | 0.797 |
EPHB4 |
0.658 | -0.029 | -1 | 0.810 |
YANK3 |
0.658 | -0.051 | 2 | 0.370 |
ROS1 |
0.657 | -0.065 | 3 | 0.790 |
LCK |
0.657 | -0.016 | -1 | 0.835 |
KDR |
0.656 | -0.013 | 3 | 0.766 |
JAK3 |
0.656 | -0.063 | 1 | 0.260 |
JAK1 |
0.656 | -0.025 | 1 | 0.249 |
TYK2 |
0.655 | -0.143 | 1 | 0.254 |
TYRO3 |
0.655 | -0.074 | 3 | 0.809 |
NEK10_TYR |
0.654 | -0.056 | 1 | 0.241 |
ABL1 |
0.654 | -0.056 | -1 | 0.786 |
BLK |
0.654 | -0.014 | -1 | 0.843 |
FGR |
0.654 | -0.088 | 1 | 0.237 |
TNNI3K_TYR |
0.653 | -0.018 | 1 | 0.275 |
STLK3 |
0.653 | -0.127 | 1 | 0.218 |
TNK2 |
0.653 | -0.031 | 3 | 0.760 |
MET |
0.652 | -0.035 | 3 | 0.792 |
YES1 |
0.652 | -0.063 | -1 | 0.825 |
CK1G3 |
0.651 | -0.034 | -3 | 0.383 |
HCK |
0.651 | -0.067 | -1 | 0.827 |
FGFR2 |
0.651 | -0.024 | 3 | 0.784 |
KIT |
0.650 | -0.070 | 3 | 0.795 |
TNK1 |
0.648 | -0.016 | 3 | 0.791 |
DDR1 |
0.648 | -0.110 | 4 | 0.777 |
FGFR1 |
0.647 | -0.023 | 3 | 0.761 |
ITK |
0.647 | -0.074 | -1 | 0.786 |
FYN |
0.647 | -0.016 | -1 | 0.822 |
INSRR |
0.647 | -0.105 | 3 | 0.748 |
FLT1 |
0.646 | -0.069 | -1 | 0.815 |
BMX |
0.646 | -0.043 | -1 | 0.736 |
EPHA4 |
0.645 | -0.060 | 2 | 0.726 |
TEK |
0.645 | -0.015 | 3 | 0.736 |
FER |
0.645 | -0.141 | 1 | 0.247 |
FLT3 |
0.644 | -0.140 | 3 | 0.809 |
SRMS |
0.644 | -0.097 | 1 | 0.223 |
EPHB1 |
0.644 | -0.097 | 1 | 0.229 |
FGFR3 |
0.643 | -0.027 | 3 | 0.754 |
PDGFRB |
0.642 | -0.142 | 3 | 0.810 |
WEE1_TYR |
0.642 | -0.063 | -1 | 0.716 |
CK1G2 |
0.641 | -0.019 | -3 | 0.464 |
FRK |
0.641 | -0.079 | -1 | 0.846 |
EPHB3 |
0.640 | -0.111 | -1 | 0.794 |
EPHB2 |
0.640 | -0.101 | -1 | 0.791 |
ZAP70 |
0.639 | 0.024 | -1 | 0.718 |
PDGFRA |
0.639 | -0.145 | 3 | 0.809 |
TEC |
0.638 | -0.099 | -1 | 0.728 |
MERTK |
0.638 | -0.095 | 3 | 0.775 |
SYK |
0.638 | -0.023 | -1 | 0.793 |
ERBB2 |
0.638 | -0.116 | 1 | 0.239 |
DDR2 |
0.637 | -0.011 | 3 | 0.732 |
EGFR |
0.636 | -0.071 | 1 | 0.208 |
ALK |
0.636 | -0.100 | 3 | 0.725 |
BTK |
0.636 | -0.144 | -1 | 0.748 |
EPHA7 |
0.636 | -0.067 | 2 | 0.726 |
SRC |
0.636 | -0.063 | -1 | 0.805 |
AXL |
0.635 | -0.134 | 3 | 0.774 |
MATK |
0.634 | -0.073 | -1 | 0.726 |
PTK2 |
0.634 | -0.027 | -1 | 0.800 |
PTK2B |
0.633 | -0.068 | -1 | 0.749 |
LYN |
0.633 | -0.096 | 3 | 0.717 |
FLT4 |
0.633 | -0.119 | 3 | 0.745 |
NTRK3 |
0.632 | -0.101 | -1 | 0.733 |
EPHA1 |
0.632 | -0.104 | 3 | 0.777 |
LTK |
0.631 | -0.123 | 3 | 0.744 |
FGFR4 |
0.631 | -0.073 | -1 | 0.746 |
EPHA3 |
0.630 | -0.107 | 2 | 0.695 |
NTRK1 |
0.630 | -0.161 | -1 | 0.773 |
ERBB4 |
0.629 | -0.043 | 1 | 0.208 |
INSR |
0.629 | -0.125 | 3 | 0.731 |
PTK6 |
0.629 | -0.149 | -1 | 0.696 |
EPHA8 |
0.629 | -0.083 | -1 | 0.801 |
NTRK2 |
0.629 | -0.160 | 3 | 0.747 |
YANK2 |
0.629 | -0.065 | 2 | 0.386 |
MUSK |
0.628 | -0.090 | 1 | 0.191 |
CSK |
0.627 | -0.112 | 2 | 0.731 |
EPHA5 |
0.624 | -0.105 | 2 | 0.704 |
EPHA2 |
0.620 | -0.081 | -1 | 0.768 |
IGF1R |
0.614 | -0.126 | 3 | 0.660 |
FES |
0.604 | -0.115 | -1 | 0.696 |