Motif 228 (n=175)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A0C4DFX4	None	S2625	ochoa	Snf2 related CREBBP activator protein	None
A7MCY6	TBKBP1	S372	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
A7MCY6	TBKBP1	S400	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
A7MCY6	TBKBP1	S415	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
B4DS77	SHISA9	S337	ochoa	Protein shisa-9	Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity). {ECO:0000250}.
E7EW31	PROB1	S862	ochoa	Proline-rich basic protein 1	None
K7ELQ4	ATF7-NPFF	S171	ochoa	ATF7-NPFF readthrough	None
O00151	PDLIM1	S130	ochoa	PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)	Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250\|UniProtKB:P52944, ECO:0000269\|PubMed:10861853}.
O00267	SUPT5H	S789	ochoa	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269\|PubMed:10075709, ECO:0000269\|PubMed:10199401, ECO:0000269\|PubMed:10393184, ECO:0000269\|PubMed:10421630, ECO:0000269\|PubMed:10454543, ECO:0000269\|PubMed:10757782, ECO:0000269\|PubMed:10912001, ECO:0000269\|PubMed:11112772, ECO:0000269\|PubMed:11553615, ECO:0000269\|PubMed:11809800, ECO:0000269\|PubMed:12653964, ECO:0000269\|PubMed:12718890, ECO:0000269\|PubMed:14701750, ECO:0000269\|PubMed:15136722, ECO:0000269\|PubMed:15380072, ECO:0000269\|PubMed:16214896, ECO:0000269\|PubMed:16427012, ECO:0000269\|PubMed:9450929, ECO:0000269\|PubMed:9514752, ECO:0000269\|PubMed:9857195}.
O00409	FOXN3	S97	ochoa	Forkhead box protein N3 (Checkpoint suppressor 1)	Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). {ECO:0000269\|PubMed:16102918}.
O00512	BCL9	S885	ochoa	B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)	Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11955446}.
O14526	FCHO1	S530	ochoa	F-BAR domain only protein 1	Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269\|PubMed:20448150, ECO:0000269\|PubMed:30822429, ECO:0000269\|PubMed:32098969}.
O15068	MCF2L	S975	ochoa	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)	Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250\|UniProtKB:Q63406, ECO:0000269\|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269\|PubMed:15157669}.
O15126	SCAMP1	S43	ochoa	Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)	Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
O15169	AXIN1	S493	ochoa	Axin-1 (Axis inhibition protein 1) (hAxin)	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269\|PubMed:12192039, ECO:0000269\|PubMed:16601693, ECO:0000269\|PubMed:17210684, ECO:0000269\|PubMed:27098453, ECO:0000269\|PubMed:28546513}.
O15417	TNRC18	S1540	ochoa	Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein)	None
O15446	POLR1G	S27	ochoa	DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49)	Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269\|PubMed:34671025, ECO:0000269\|PubMed:34887565, ECO:0000269\|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269\|PubMed:10373416}.
O43166	SIPA1L1	S1087	ochoa	Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43365	HOXA3	S148	ochoa	Homeobox protein Hox-A3 (Homeobox protein Hox-1E)	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
O43516	WIPF1	S350	ochoa	WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269\|PubMed:10878810, ECO:0000269\|PubMed:19910490, ECO:0000269\|PubMed:9405671}.
O43566	RGS14	S456	ochoa	Regulator of G-protein signaling 14 (RGS14)	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269\|PubMed:15917656, ECO:0000269\|PubMed:17635935}.
O60341	KDM1A	S69	ochoa	Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)	Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269\|PubMed:12032298, ECO:0000269\|PubMed:15620353, ECO:0000269\|PubMed:15811342, ECO:0000269\|PubMed:16079794, ECO:0000269\|PubMed:16079795, ECO:0000269\|PubMed:16140033, ECO:0000269\|PubMed:16223729, ECO:0000269\|PubMed:16885027, ECO:0000269\|PubMed:16956976, ECO:0000269\|PubMed:17805299, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:20562920, ECO:0000269\|PubMed:21300290, ECO:0000269\|PubMed:23721412, ECO:0000269\|PubMed:27292636, ECO:0000269\|PubMed:29358331, ECO:0000269\|PubMed:29691401, ECO:0000269\|PubMed:34655521, ECO:0000269\|PubMed:34906447}.
O60346	PHLPP1	S324	ochoa\|psp	PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250\|UniProtKB:Q8CHE4, ECO:0000250\|UniProtKB:Q9WTR8, ECO:0000269\|PubMed:15808505, ECO:0000269\|PubMed:17386267, ECO:0000269\|PubMed:18162466, ECO:0000269\|PubMed:19079341, ECO:0000269\|PubMed:21986499, ECO:0000269\|PubMed:24530606}.
O60346	PHLPP1	S411	ochoa\|psp	PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250\|UniProtKB:Q8CHE4, ECO:0000250\|UniProtKB:Q9WTR8, ECO:0000269\|PubMed:15808505, ECO:0000269\|PubMed:17386267, ECO:0000269\|PubMed:18162466, ECO:0000269\|PubMed:19079341, ECO:0000269\|PubMed:21986499, ECO:0000269\|PubMed:24530606}.
O60673	REV3L	S2183	ochoa	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)	Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269\|PubMed:24449906}.
O75376	NCOR1	S1671	ochoa	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250\|UniProtKB:Q60974, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:20812024}.
O75385	ULK1	S588	ochoa	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)	Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269\|PubMed:11146101, ECO:0000269\|PubMed:18936157, ECO:0000269\|PubMed:20921139, ECO:0000269\|PubMed:21460634, ECO:0000269\|PubMed:21795849, ECO:0000269\|PubMed:23524951, ECO:0000269\|PubMed:25040165, ECO:0000269\|PubMed:25126726, ECO:0000269\|PubMed:28821708, ECO:0000269\|PubMed:29487085, ECO:0000269\|PubMed:31123703, ECO:0000269\|PubMed:37306101}.
O94967	WDR47	S297	ochoa	WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)	None
O95785	WIZ	S1146	ochoa	Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803)	May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}.
P03372	ESR1	S118	psp	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250\|UniProtKB:P06211, ECO:0000269\|PubMed:10681512, ECO:0000269\|PubMed:10816575, ECO:0000269\|PubMed:11477071, ECO:0000269\|PubMed:11682626, ECO:0000269\|PubMed:14764652, ECO:0000269\|PubMed:15078875, ECO:0000269\|PubMed:15891768, ECO:0000269\|PubMed:16043358, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:16684779, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:17932106, ECO:0000269\|PubMed:18247370, ECO:0000269\|PubMed:19350539, ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:20705611, ECO:0000269\|PubMed:21330404, ECO:0000269\|PubMed:22083956, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:7651415, ECO:0000269\|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269\|PubMed:10970861, ECO:0000269\|PubMed:21937726}.
P06400	RB1	S249	ochoa\|psp	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250\|UniProtKB:P13405, ECO:0000250\|UniProtKB:P33568, ECO:0000269\|PubMed:10499802, ECO:0000269\|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269\|PubMed:1316611, ECO:0000269\|PubMed:17974914, ECO:0000269\|PubMed:18701596, ECO:0000269\|PubMed:2839300, ECO:0000269\|PubMed:8892909}.
P06400	RB1	S780	ochoa\|psp	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250\|UniProtKB:P13405, ECO:0000250\|UniProtKB:P33568, ECO:0000269\|PubMed:10499802, ECO:0000269\|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269\|PubMed:1316611, ECO:0000269\|PubMed:17974914, ECO:0000269\|PubMed:18701596, ECO:0000269\|PubMed:2839300, ECO:0000269\|PubMed:8892909}.
P08651	NFIC	S427	ochoa	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
P10070	GLI2	S1101	ochoa	Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)	Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250\|UniProtKB:Q0VGT2, ECO:0000269\|PubMed:15994174, ECO:0000269\|PubMed:18455992, ECO:0000269\|PubMed:19878745, ECO:0000269\|PubMed:24311597, ECO:0000269\|PubMed:26565916, ECO:0000269\|PubMed:9557682, ECO:0000305\|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269\|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269\|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269\|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269\|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269\|PubMed:15994174, ECO:0000269\|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269\|PubMed:15994174, ECO:0000269\|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269\|PubMed:15994174, ECO:0000269\|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269\|PubMed:15994174, ECO:0000269\|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269\|PubMed:15994174}.
P15822	HIVEP1	S2353	ochoa	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P15941	MUC1	Y1209	ochoa	Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]	The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; FUNCTION: The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
P15976	GATA1	S161	psp	Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein)	Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269\|PubMed:22235304, ECO:0000269\|PubMed:24245781, ECO:0000269\|PubMed:35030251}.
P18583	SON	S966	ochoa	Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)	RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269\|PubMed:20581448, ECO:0000269\|PubMed:21504830, ECO:0000269\|PubMed:27545680}.
P20719	HOXA5	S104	ochoa	Homeobox protein Hox-A5 (Homeobox protein Hox-1C)	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
P21580	TNFAIP3	S466	ochoa	Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]	Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269\|PubMed:14748687, ECO:0000269\|PubMed:15258597, ECO:0000269\|PubMed:16684768, ECO:0000269\|PubMed:17961127, ECO:0000269\|PubMed:18164316, ECO:0000269\|PubMed:18952128, ECO:0000269\|PubMed:19494296, ECO:0000269\|PubMed:22099304, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:8692885, ECO:0000269\|PubMed:9299557, ECO:0000269\|PubMed:9882303}.
P22736	NR4A1	S152	psp	Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)	Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250\|UniProtKB:P12813, ECO:0000250\|UniProtKB:P22829, ECO:0000269\|PubMed:15466594, ECO:0000269\|PubMed:18690216, ECO:0000269\|PubMed:22983157, ECO:0000269\|PubMed:8121493, ECO:0000269\|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250\|UniProtKB:P12813}.
P30260	CDC27	S364	ochoa	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
P30291	WEE1	S67	ochoa\|psp	Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269\|PubMed:15070733, ECO:0000269\|PubMed:7743995, ECO:0000269\|PubMed:8348613, ECO:0000269\|PubMed:8428596}.
P33991	MCM4	S54	ochoa\|psp	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269\|PubMed:16899510, ECO:0000269\|PubMed:25661590, ECO:0000269\|PubMed:32453425, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:34700328, ECO:0000269\|PubMed:35585232, ECO:0000269\|PubMed:9305914}.
P39880	CUX1	S914	ochoa	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]	Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250\|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269\|PubMed:15099520}.
P41182	BCL6	S243	ochoa	B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51)	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269\|PubMed:10981963, ECO:0000269\|PubMed:12402037, ECO:0000269\|PubMed:12414651, ECO:0000269\|PubMed:12504096, ECO:0000269\|PubMed:15454082, ECO:0000269\|PubMed:15577913, ECO:0000269\|PubMed:16142238, ECO:0000269\|PubMed:17828269, ECO:0000269\|PubMed:18212045, ECO:0000269\|PubMed:18280243, ECO:0000269\|PubMed:22113614, ECO:0000269\|PubMed:23166356, ECO:0000269\|PubMed:23911289, ECO:0000269\|PubMed:9649500}.
P46060	RANGAP1	S428	ochoa\|psp	Ran GTPase-activating protein 1 (RanGAP1)	GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269\|PubMed:16428860, ECO:0000269\|PubMed:27160050, ECO:0000269\|PubMed:8146159, ECO:0000269\|PubMed:8896452}.
P46821	MAP1B	S1625	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P54284	CACNB3	S152	ochoa	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)	Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). {ECO:0000250\|UniProtKB:P54287, ECO:0000250\|UniProtKB:Q9MZL3, ECO:0000269\|PubMed:8119293}.
P56524	HDAC4	S348	ochoa	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269\|PubMed:10523670, ECO:0000269\|PubMed:24413532, ECO:0000269\|PubMed:27708256}.
P78524	DENND2B	S552	ochoa	DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)	[Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269\|PubMed:29030480, ECO:0000269\|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269\|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305\|PubMed:10229203, ECO:0000305\|PubMed:9632734}.
P78559	MAP1A	S1172	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559	MAP1A	S2235	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P78559	MAP1A	S2629	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P85037	FOXK1	S428	ochoa	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250\|UniProtKB:P42128, ECO:0000269\|PubMed:17670796, ECO:0000269\|PubMed:24634419, ECO:0000269\|PubMed:25805136, ECO:0000269\|PubMed:25852164, ECO:0000269\|PubMed:30664650}.
P98171	ARHGAP4	S906	ochoa	Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115)	Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q00587	CDC42EP1	S113	ochoa	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)	Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269\|PubMed:10430899}.
Q01780	EXOSC10	S217	ochoa	Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)	Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250\|UniProtKB:P56960, ECO:0000269\|PubMed:14527413, ECO:0000269\|PubMed:16455498, ECO:0000269\|PubMed:17412707, ECO:0000269\|PubMed:17545563, ECO:0000269\|PubMed:18172165, ECO:0000269\|PubMed:19056938, ECO:0000269\|PubMed:20368444, ECO:0000269\|PubMed:20699273, ECO:0000269\|PubMed:25632158, ECO:0000269\|PubMed:26857222, ECO:0000269\|PubMed:31086179, ECO:0000269\|PubMed:32830871, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:36912080}.
Q06190	PPP2R3A	S692	ochoa	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B)	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q07890	SOS2	S1267	ochoa	Son of sevenless homolog 2 (SOS-2)	Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250\|UniProtKB:Q62245}.
Q08999	RBL2	S1080	ochoa\|psp	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Q12774	ARHGEF5	Y526	ochoa	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250\|UniProtKB:E9Q7D5, ECO:0000269\|PubMed:14662653, ECO:0000269\|PubMed:15601624}.
Q13207	TBX2	S386	ochoa	T-box transcription factor TBX2 (T-box protein 2)	Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250\|UniProtKB:Q60707, ECO:0000269\|PubMed:11062467, ECO:0000269\|PubMed:11111039, ECO:0000269\|PubMed:12000749, ECO:0000269\|PubMed:22002537, ECO:0000269\|PubMed:22844464, ECO:0000269\|PubMed:28910203, ECO:0000269\|PubMed:29726930, ECO:0000269\|PubMed:30599067}.
Q13233	MAP3K1	S297	ochoa	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)	Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269\|PubMed:17761173, ECO:0000269\|PubMed:9808624}.
Q13435	SF3B2	S655	ochoa	Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
Q13443	ADAM9	S758	ochoa	Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)	Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250\|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269\|PubMed:12054541}.
Q13501	SQSTM1	S207	ochoa\|psp	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)	Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250\|UniProtKB:Q64337, ECO:0000269\|PubMed:10356400, ECO:0000269\|PubMed:10747026, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:12471037, ECO:0000269\|PubMed:15340068, ECO:0000269\|PubMed:15802564, ECO:0000269\|PubMed:15911346, ECO:0000269\|PubMed:15953362, ECO:0000269\|PubMed:16079148, ECO:0000269\|PubMed:16286508, ECO:0000269\|PubMed:17580304, ECO:0000269\|PubMed:19931284, ECO:0000269\|PubMed:20168092, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:22017874, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:24128730, ECO:0000269\|PubMed:25101860, ECO:0000269\|PubMed:26344566, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:28404643, ECO:0000269\|PubMed:29343546, ECO:0000269\|PubMed:29496741, ECO:0000269\|PubMed:29507397, ECO:0000269\|PubMed:31857589, ECO:0000269\|PubMed:33393215, ECO:0000269\|PubMed:33472082, ECO:0000269\|PubMed:33509017, ECO:0000269\|PubMed:34471133, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:35831301, ECO:0000269\|PubMed:37306101, ECO:0000269\|PubMed:37802024}.
Q13542	EIF4EBP2	S83	ochoa	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250\|UniProtKB:P70445, ECO:0000269\|PubMed:25533957, ECO:0000269\|PubMed:30765518}.
Q14451	GRB7	S76	ochoa	Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269\|PubMed:10893408, ECO:0000269\|PubMed:12021278, ECO:0000269\|PubMed:12223469, ECO:0000269\|PubMed:20622016}.
Q14684	RRP1B	S513	ochoa	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250\|UniProtKB:Q91YK2, ECO:0000269\|PubMed:19710015, ECO:0000269\|PubMed:20040599, ECO:0000269\|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269\|PubMed:26311876}.
Q14687	GSE1	S186	ochoa	Genetic suppressor element 1	None
Q14687	GSE1	S840	ochoa	Genetic suppressor element 1	None
Q14934	NFATC4	S259	ochoa\|psp	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)	Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250\|UniProtKB:D3Z9H7, ECO:0000250\|UniProtKB:Q8K120, ECO:0000269\|PubMed:11514544, ECO:0000269\|PubMed:11997522, ECO:0000269\|PubMed:17213202, ECO:0000269\|PubMed:17875713, ECO:0000269\|PubMed:18347059, ECO:0000269\|PubMed:18668201, ECO:0000269\|PubMed:25663301, ECO:0000269\|PubMed:7749981, ECO:0000305}.
Q14934	NFATC4	S264	ochoa	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3)	Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250\|UniProtKB:D3Z9H7, ECO:0000250\|UniProtKB:Q8K120, ECO:0000269\|PubMed:11514544, ECO:0000269\|PubMed:11997522, ECO:0000269\|PubMed:17213202, ECO:0000269\|PubMed:17875713, ECO:0000269\|PubMed:18347059, ECO:0000269\|PubMed:18668201, ECO:0000269\|PubMed:25663301, ECO:0000269\|PubMed:7749981, ECO:0000305}.
Q15583	TGIF1	S95	ochoa	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)	Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Q15700	DLG2	S328	ochoa	Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)	Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
Q15742	NAB2	S171	ochoa	NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)	Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q15788	NCOA1	S1033	psp	Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269\|PubMed:10449719, ECO:0000269\|PubMed:12954634, ECO:0000269\|PubMed:7481822, ECO:0000269\|PubMed:9223281, ECO:0000269\|PubMed:9223431, ECO:0000269\|PubMed:9296499, ECO:0000269\|PubMed:9427757}.
Q16584	MAP3K11	S770	psp	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)	Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269\|PubMed:12529434, ECO:0000269\|PubMed:15258589, ECO:0000269\|PubMed:8195146, ECO:0000269\|PubMed:9003778}.
Q17RH5	RAPGEF2	S1010	psp	Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (Neural RAP guanine nucleotide exchange protein) (PDZ domain-containing guanine nucleotide exchange factor 1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)	None
Q2M1Z3	ARHGAP31	S1036	ochoa	Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)	Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269\|PubMed:12192056, ECO:0000269\|PubMed:16519628}.
Q4KMQ1	TPRN	S254	ochoa	Taperin	Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250\|UniProtKB:A2AI08, ECO:0000269\|PubMed:23213405}.
Q4VCS5	AMOT	S332	ochoa	Angiomotin	Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269\|PubMed:11257124, ECO:0000269\|PubMed:16678097, ECO:0000269\|PubMed:21205866}.
Q58A45	PAN3	S368	ochoa	PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)	Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255\|HAMAP-Rule:MF_03181, ECO:0000269\|PubMed:14583602, ECO:0000269\|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269\|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269\|PubMed:28559491}.
Q5JR12	PPM1J	S25	ochoa	Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta)	None
Q5T7N3	KANK4	S92	ochoa	KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38)	May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269\|PubMed:17996375}.
Q5VZK9	CARMIL1	S1261	ochoa	F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)	Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269\|PubMed:16054028, ECO:0000269\|PubMed:19846667}.
Q63HR2	TNS2	S972	ochoa	Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)	Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250\|UniProtKB:Q8CGB6, ECO:0000269\|PubMed:15817639, ECO:0000269\|PubMed:20069572, ECO:0000269\|PubMed:23401856, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:28955049, ECO:0000269\|PubMed:30092354}.
Q68CZ2	TNS3	S379	ochoa	Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250\|UniProtKB:Q5SSZ5, ECO:0000269\|PubMed:17643115, ECO:0000269\|PubMed:26166433, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:31905841, ECO:0000269\|PubMed:35687021, ECO:0000305}.
Q68DA7	FMN1	S525	ochoa	Formin-1 (Limb deformity protein homolog)	Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.
Q68DA7	FMN1	S620	ochoa	Formin-1 (Limb deformity protein homolog)	Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.
Q68EM7	ARHGAP17	S667	ochoa	Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)	Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269\|PubMed:11431473, ECO:0000269\|PubMed:16678097}.
Q68EM7	ARHGAP17	S674	ochoa	Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)	Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269\|PubMed:11431473, ECO:0000269\|PubMed:16678097}.
Q6BDS2	BLTP3A	S444	ochoa	Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1)	Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269\|PubMed:35499567}.
Q6BEB4	SP5	S126	ochoa	Transcription factor Sp5	Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}.
Q6IN85	PPP4R3A	S789	ochoa	Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)	Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269\|PubMed:18614045}.
Q6IPM2	IQCE	S590	ochoa	IQ domain-containing protein E	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250\|UniProtKB:Q6PCQ0, ECO:0000269\|PubMed:28488682}.
Q6KC79	NIPBL	S162	ochoa	Nipped-B-like protein (Delangin) (SCC2 homolog)	Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250\|UniProtKB:Q6KCD5, ECO:0000269\|PubMed:22628566, ECO:0000269\|PubMed:28167679, ECO:0000269\|PubMed:28914604}.
Q6P0Q8	MAST2	S209	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PCB5	RSBN1L	S79	ochoa	Lysine-specific demethylase RSBN1L (EC 1.14.11.-) (Round spermatid basic protein 1-like protein)	Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins. {ECO:0000250\|UniProtKB:Q80T69}.
Q6PJF5	RHBDF2	S325	ochoa	Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)	Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250\|UniProtKB:Q80WQ6}.
Q6UB99	ANKRD11	S1859	ochoa	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250\|UniProtKB:E9Q4F7, ECO:0000269\|PubMed:15184363, ECO:0000269\|PubMed:25556659}.
Q6UUV7	CRTC3	S396	ochoa	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.
Q6ZRS2	SRCAP	S2802	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q6ZS30	NBEAL1	S734	ochoa	Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)	None
Q6ZTU2	EP400P1	S129	ochoa	Putative EP400-like protein (EP400 pseudogene 1)	None
Q76L83	ASXL2	S600	ochoa	Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BZ32, ECO:0000269\|PubMed:21047783, ECO:0000269\|PubMed:30664650, ECO:0000269\|PubMed:36180891}.
Q7Z591	AKNA	S1102	ochoa	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250\|UniProtKB:Q80VW7, ECO:0000269\|PubMed:11268217, ECO:0000305}.
Q7Z5L9	IRF2BP2	S406	ochoa	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269\|PubMed:12799427, ECO:0000269\|PubMed:20702774, ECO:0000269\|PubMed:21576369, ECO:0000269\|PubMed:27016798}.
Q86TB9	PATL1	S184	ochoa	Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)	RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269\|PubMed:17936923, ECO:0000269\|PubMed:20543818, ECO:0000269\|PubMed:20584987, ECO:0000269\|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269\|PubMed:19628699}.
Q86UU0	BCL9L	S947	ochoa	B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2)	Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86UU0	BCL9L	S954	ochoa	B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2)	Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86WB0	ZC3HC1	S370	ochoa\|psp	Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase)	Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269\|PubMed:34440706}.
Q86YN6	PPARGC1B	S239	ochoa	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269\|PubMed:11854298, ECO:0000269\|PubMed:12678921, ECO:0000269\|PubMed:15546003, ECO:0000269\|PubMed:23836911}.
Q86YN6	PPARGC1B	S389	ochoa	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269\|PubMed:11854298, ECO:0000269\|PubMed:12678921, ECO:0000269\|PubMed:15546003, ECO:0000269\|PubMed:23836911}.
Q8IUW5	RELL1	S166	ochoa	RELT-like protein 1	Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269\|PubMed:19969290, ECO:0000269\|PubMed:28688764}.
Q8IWY9	CDAN1	S277	ochoa	Codanin-1	May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269\|PubMed:22407294}.
Q8IY92	SLX4	S584	ochoa	Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)	Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269\|PubMed:19595721, ECO:0000269\|PubMed:19595722, ECO:0000269\|PubMed:19596235, ECO:0000269\|PubMed:19596236}.
Q8IYB3	SRRM1	S414	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8N1I0	DOCK4	S1815	ochoa	Dedicator of cytokinesis protein 4	Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269\|PubMed:12628187, ECO:0000269\|PubMed:16464467, ECO:0000269\|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269\|PubMed:16464467}.
Q8N3F8	MICALL1	S621	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3V7	SYNPO	S864	ochoa	Synaptopodin	Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N3V7	SYNPO	S882	ochoa	Synaptopodin	Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N4S9	MARVELD2	S140	ochoa	MARVEL domain-containing protein 2 (Tricellulin)	Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250\|UniProtKB:Q3UZP0, ECO:0000269\|PubMed:17186462}.
Q8N8K9	KIAA1958	Y102	ochoa	Uncharacterized protein KIAA1958	None
Q8NAX2	KDF1	S179	ochoa	Keratinocyte differentiation factor 1	Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250\|UniProtKB:A2A9F4}.
Q8NDX5	PHC3	S298	ochoa	Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269\|PubMed:12167701}.
Q8TCT7	SPPL2B	S550	ochoa	Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269\|PubMed:16829951, ECO:0000269\|PubMed:16829952, ECO:0000269\|PubMed:17965014, ECO:0000269\|PubMed:19114711, ECO:0000269\|PubMed:22194595, ECO:0000269\|PubMed:23132852}.
Q8TE67	EPS8L3	S214	ochoa	Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3)	None
Q8TES7	FBF1	S334	ochoa\|psp	Fas-binding factor 1 (FBF-1) (Protein albatross)	Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269\|PubMed:18838552, ECO:0000269\|PubMed:23348840}.
Q8TEW8	PARD3B	S1184	ochoa	Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)	Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q92545	TMEM131	S1375	ochoa	Transmembrane protein 131 (Protein RW1)	Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269\|PubMed:32095531}.
Q92835	INPP5D	S934	ochoa	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269\|PubMed:10764818, ECO:0000269\|PubMed:12421919, ECO:0000269\|PubMed:16682172, ECO:0000269\|PubMed:8723348, ECO:0000269\|PubMed:8769125, ECO:0000269\|PubMed:9108392}.
Q93015	NAA80	S217	ochoa	N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2)	N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269\|PubMed:10644992, ECO:0000269\|PubMed:29581253, ECO:0000269\|PubMed:29581307, ECO:0000269\|PubMed:30028079}.
Q96AP7	ESAM	S359	ochoa	Endothelial cell-selective adhesion molecule	Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250\|UniProtKB:Q925F2}.
Q96JM3	CHAMP1	S260	ochoa	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269\|PubMed:21063390}.
Q96JM7	L3MBTL3	S608	ochoa	Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)	Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250\|UniProtKB:Q8BLB7, ECO:0000269\|PubMed:29030483, ECO:0000269\|PubMed:29691401, ECO:0000269\|PubMed:30442713}.
Q96L91	EP400	S140	ochoa	E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:24463511}.
Q96LL9	DNAJC30	S137	ochoa	DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein)	Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (PubMed:33465056). {ECO:0000250\|UniProtKB:P59041, ECO:0000269\|PubMed:33465056}.
Q96PC5	MIA2	S1156	ochoa	Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11)	Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250\|UniProtKB:Q91ZV0, ECO:0000269\|PubMed:21525241, ECO:0000269\|PubMed:25202031, ECO:0000269\|PubMed:27138255, ECO:0000269\|PubMed:27170179}.
Q99081	TCF12	S366	ochoa	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250\|UniProtKB:Q61286, ECO:0000269\|PubMed:32620954}.
Q99583	MNT	S162	ochoa	Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)	Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Q99700	ATXN2	S692	psp	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q9BR39	JPH2	S469	ochoa	Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)]	[Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250\|UniProtKB:Q9ET78, ECO:0000269\|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250\|UniProtKB:Q9ET78}.
Q9BRQ0	PYGO2	S97	ochoa	Pygopus homolog 2	Involved in signal transduction through the Wnt pathway.
Q9BUR4	WRAP53	S26	ochoa	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)	RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269\|PubMed:19179534, ECO:0000269\|PubMed:19285445, ECO:0000269\|PubMed:20351177, ECO:0000269\|PubMed:21072240, ECO:0000269\|PubMed:22547674, ECO:0000269\|PubMed:25512560, ECO:0000269\|PubMed:26170453, ECO:0000269\|PubMed:27525486, ECO:0000269\|PubMed:27715493, ECO:0000269\|PubMed:29695869, ECO:0000269\|PubMed:29804836}.
Q9BUR4	WRAP53	S54	ochoa	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)	RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269\|PubMed:19179534, ECO:0000269\|PubMed:19285445, ECO:0000269\|PubMed:20351177, ECO:0000269\|PubMed:21072240, ECO:0000269\|PubMed:22547674, ECO:0000269\|PubMed:25512560, ECO:0000269\|PubMed:26170453, ECO:0000269\|PubMed:27525486, ECO:0000269\|PubMed:27715493, ECO:0000269\|PubMed:29695869, ECO:0000269\|PubMed:29804836}.
Q9BWN1	PRR14	S162	ochoa	Proline-rich protein 14	Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269\|PubMed:24209742, ECO:0000269\|PubMed:25906157, ECO:0000269\|PubMed:27041574}.
Q9BX66	SORBS1	S242	ochoa	Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250\|UniProtKB:Q62417}.
Q9BZE0	GLIS2	S419	ochoa	Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein)	Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). {ECO:0000250}.
Q9C0H5	ARHGAP39	S286	ochoa	Rho GTPase-activating protein 39	None
Q9C0K0	BCL11B	S381	ochoa	B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)	Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q99PV8, ECO:0000269\|PubMed:16809611, ECO:0000269\|PubMed:27959755}.
Q9H2F5	EPC1	S357	ochoa	Enhancer of polycomb homolog 1	Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250\|UniProtKB:Q8C9X6, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:32209463}.
Q9H4M7	PLEKHA4	S241	ochoa	Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)	Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269\|PubMed:11001876}.
Q9H792	PEAK1	S861	ochoa	Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)	Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269\|PubMed:20534451, ECO:0000269\|PubMed:23105102, ECO:0000269\|PubMed:23846654, ECO:0000269\|PubMed:35687021}.
Q9H7P9	PLEKHG2	S450	ochoa	Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)	May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250\|UniProtKB:Q6KAU7, ECO:0000269\|PubMed:18045877, ECO:0000269\|PubMed:26573021}.
Q9H987	SYNPO2L	S790	ochoa	Synaptopodin 2-like protein	Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}.
Q9HAW0	BRF2	S365	ochoa	Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU)	General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269\|PubMed:11040218, ECO:0000269\|PubMed:11121026, ECO:0000269\|PubMed:11564744, ECO:0000269\|PubMed:26638071}.
Q9NQS7	INCENP	S197	ochoa	Inner centromere protein	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250\|UniProtKB:P53352, ECO:0000269\|PubMed:12925766, ECO:0000269\|PubMed:15316025, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:21346195, ECO:0000269\|PubMed:27332895}.
Q9P2J2	IGSF9	S809	ochoa	Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A)	Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}.
Q9P2R6	RERE	S1115	ochoa	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269\|PubMed:11331249}.
Q9UBP9	GULP1	S223	ochoa	PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)	May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269\|PubMed:10574763, ECO:0000269\|PubMed:10574771, ECO:0000269\|PubMed:16497666, ECO:0000269\|PubMed:17398097}.
Q9UHV7	MED13	S537	ochoa	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:16595664}.
Q9UI10	EIF2B4	S130	ochoa	Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta)	Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269\|PubMed:25858979, ECO:0000269\|PubMed:27023709, ECO:0000269\|PubMed:31048492}.
Q9UIF8	BAZ2B	S556	ochoa	Bromodomain adjacent to zinc finger domain protein 2B (hWALp4)	Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250\|UniProtKB:A2AUY4, ECO:0000269\|PubMed:28801535, ECO:0000303\|PubMed:10662543}.
Q9UKL3	CASP8AP2	S858	ochoa	CASP8-associated protein 2 (FLICE-associated huge protein)	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Q9UKS6	PACSIN3	S341	ochoa	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)	Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11082044}.
Q9UMS6	SYNPO2	S623	ochoa	Synaptopodin-2 (Genethonin-2) (Myopodin)	Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250\|UniProtKB:D4A702, ECO:0000250\|UniProtKB:Q91YE8, ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:23225103, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213, ECO:0000305\|PubMed:16885336, ECO:0000305\|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213}.
Q9UPY8	MAPRE3	S162	ochoa\|psp	Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)	Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). {ECO:0000269\|PubMed:19255245, ECO:0000269\|PubMed:28814570}.
Q9Y4G8	RAPGEF2	S1022	ochoa	Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)	Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269\|PubMed:10548487, ECO:0000269\|PubMed:10608844, ECO:0000269\|PubMed:10608883, ECO:0000269\|PubMed:10801446, ECO:0000269\|PubMed:10934204, ECO:0000269\|PubMed:11359771, ECO:0000269\|PubMed:12391161, ECO:0000269\|PubMed:16272156, ECO:0000269\|PubMed:17724123, ECO:0000269\|PubMed:21840392, ECO:0000269\|PubMed:23800469}.
Q9Y4R8	TELO2	S637	ochoa	Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)	Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269\|PubMed:12670948, ECO:0000269\|PubMed:20810650}.
Q9Y6G9	DYNC1LI1	S398	ochoa	Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269\|PubMed:19229290, ECO:0000269\|PubMed:20026645}.
Q9Y6N7	ROBO1	S1442	ochoa	Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)	Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250\|UniProtKB:O89026, ECO:0000269\|PubMed:10102268, ECO:0000269\|PubMed:24560577, ECO:0000269\|PubMed:26529257, ECO:0000305}.
Q9Y6R0	NUMBL	S270	ochoa	Numb-like protein (Numb-related protein) (Numb-R)	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269\|PubMed:18299187, ECO:0000269\|PubMed:20079715}.
P56945	BCAR1	Y115	SIGNOR\|iPTMNet\|EPSD	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250\|UniProtKB:Q61140, ECO:0000269\|PubMed:12432078, ECO:0000269\|PubMed:12832404, ECO:0000269\|PubMed:17038317}.

Download

reactome_id	name	p	-log10_p
R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	0.000211	3.676
R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	0.000155	3.810
R-HSA-73887	Death Receptor Signaling	0.000781	3.107
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	0.001245	2.905
R-HSA-162582	Signal Transduction	0.001424	2.847
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.001609	2.793
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.002317	2.635
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	0.002548	2.594
R-HSA-8941284	RUNX2 regulates chondrocyte maturation	0.002892	2.539
R-HSA-193648	NRAGE signals death through JNK	0.006066	2.217
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.006745	2.171
R-HSA-428543	Inactivation of CDC42 and RAC1	0.008193	2.087
R-HSA-193704	p75 NTR receptor-mediated signalling	0.008280	2.082
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.007638	2.117
R-HSA-5467345	Deletions in the AXIN1 gene destabilize the destruction complex	0.011116	1.954
R-HSA-9661070	Defective translocation of RB1 mutants to the nucleus	0.011116	1.954
R-HSA-428540	Activation of RAC1	0.012525	1.902
R-HSA-4839735	Signaling by AXIN mutants	0.012525	1.902
R-HSA-9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	0.012525	1.902
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.012921	1.889
R-HSA-69242	S Phase	0.011434	1.942
R-HSA-8941326	RUNX2 regulates bone development	0.012819	1.892
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.015319	1.815
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.015856	1.800
R-HSA-8985801	Regulation of cortical dendrite branching	0.043733	1.359
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.064880	1.188
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ...	0.064880	1.188
R-HSA-8985586	SLIT2:ROBO1 increases RHOA activity	0.085563	1.068
R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.085563	1.068
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	0.021473	1.668
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	0.105790	0.976
R-HSA-72731	Recycling of eIF2:GDP	0.105790	0.976
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.144920	0.839
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.144920	0.839
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.144920	0.839
R-HSA-112308	Presynaptic depolarization and calcium channel opening	0.144920	0.839
R-HSA-5339716	Signaling by GSK3beta mutants	0.154434	0.811
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.163842	0.786
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.163842	0.786
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.163842	0.786
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.163842	0.786
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.163842	0.786
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	0.173146	0.762
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	0.173146	0.762
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.062019	1.207
R-HSA-69166	Removal of the Flap Intermediate	0.182347	0.739
R-HSA-196299	Beta-catenin phosphorylation cascade	0.191446	0.718
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL...	0.200445	0.698
R-HSA-5656121	Translesion synthesis by POLI	0.200445	0.698
R-HSA-176412	Phosphorylation of the APC/C	0.200445	0.698
R-HSA-5083625	Defective GALNT3 causes HFTC	0.200445	0.698
R-HSA-5083636	Defective GALNT12 causes CRCS1	0.200445	0.698
R-HSA-5655862	Translesion synthesis by POLK	0.209344	0.679
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.209344	0.679
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.218144	0.661
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.218144	0.661
R-HSA-5083632	Defective C1GALT1C1 causes TNPS	0.218144	0.661
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.226847	0.644
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.235454	0.628
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.235454	0.628
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	0.243965	0.613
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.243965	0.613
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.252383	0.598
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	0.260707	0.584
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	0.260707	0.584
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.260707	0.584
R-HSA-383280	Nuclear Receptor transcription pathway	0.072832	1.138
R-HSA-977068	Termination of O-glycan biosynthesis	0.277079	0.557
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	0.149316	0.826
R-HSA-141424	Amplification of signal from the kinetochores	0.089329	1.049
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.089329	1.049
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.308750	0.510
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.308750	0.510
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.308750	0.510
R-HSA-1989781	PPARA activates gene expression	0.130125	0.886
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.134043	0.873
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.021246	1.673
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.021246	1.673
R-HSA-69183	Processive synthesis on the lagging strand	0.191446	0.718
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.308750	0.510
R-HSA-9018519	Estrogen-dependent gene expression	0.029567	1.529
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.021246	1.673
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.085563	1.068
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.268938	0.570
R-HSA-73863	RNA Polymerase I Transcription Termination	0.308750	0.510
R-HSA-453276	Regulation of mitotic cell cycle	0.221221	0.655
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.221221	0.655
R-HSA-69618	Mitotic Spindle Checkpoint	0.036853	1.434
R-HSA-8939211	ESR-mediated signaling	0.026393	1.579
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.119076	0.924
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.154434	0.811
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.218144	0.661
R-HSA-69186	Lagging Strand Synthesis	0.252383	0.598
R-HSA-2467813	Separation of Sister Chromatids	0.148125	0.829
R-HSA-69190	DNA strand elongation	0.068124	1.167
R-HSA-9675126	Diseases of mitotic cell cycle	0.068124	1.167
R-HSA-110312	Translesion synthesis by REV1	0.191446	0.718
R-HSA-3214815	HDACs deacetylate histones	0.157069	0.804
R-HSA-9843745	Adipogenesis	0.083984	1.076
R-HSA-180786	Extension of Telomeres	0.172793	0.762
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.217134	0.663
R-HSA-4791275	Signaling by WNT in cancer	0.068124	1.167
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	0.062019	1.207
R-HSA-8875513	MET interacts with TNS proteins	0.054365	1.265
R-HSA-69478	G2/M DNA replication checkpoint	0.095733	1.019
R-HSA-2470946	Cohesin Loading onto Chromatin	0.105790	0.976
R-HSA-176974	Unwinding of DNA	0.125573	0.901
R-HSA-350054	Notch-HLH transcription pathway	0.039728	1.401
R-HSA-4839744	Signaling by APC mutants	0.144920	0.839
R-HSA-209560	NF-kB is activated and signals survival	0.154434	0.811
R-HSA-4839748	Signaling by AMER1 mutants	0.154434	0.811
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.209344	0.679
R-HSA-5689896	Ovarian tumor domain proteases	0.087528	1.058
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.226847	0.644
R-HSA-73980	RNA Polymerase III Transcription Termination	0.226847	0.644
R-HSA-113510	E2F mediated regulation of DNA replication	0.235454	0.628
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.285130	0.545
R-HSA-933542	TRAF6 mediated NF-kB activation	0.285130	0.545
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.111912	0.951
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.045014	1.347
R-HSA-376176	Signaling by ROBO receptors	0.237709	0.624
R-HSA-6794361	Neurexins and neuroligins	0.145469	0.837
R-HSA-9006931	Signaling by Nuclear Receptors	0.067299	1.172
R-HSA-193639	p75NTR signals via NF-kB	0.191446	0.718
R-HSA-209543	p75NTR recruits signalling complexes	0.163842	0.786
R-HSA-69239	Synthesis of DNA	0.149311	0.826
R-HSA-9009391	Extra-nuclear estrogen signaling	0.131380	0.881
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	0.097776	1.010
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	0.097776	1.010
R-HSA-9620244	Long-term potentiation	0.293091	0.533
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.113117	0.946
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.046682	1.331
R-HSA-69236	G1 Phase	0.115549	0.937
R-HSA-69231	Cyclin D associated events in G1	0.115549	0.937
R-HSA-73893	DNA Damage Bypass	0.134061	0.873
R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO	0.125573	0.901
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.173146	0.762
R-HSA-9707616	Heme signaling	0.044563	1.351
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.308750	0.510
R-HSA-429914	Deadenylation-dependent mRNA decay	0.172793	0.762
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	0.101265	0.995
R-HSA-69306	DNA Replication	0.299240	0.524
R-HSA-1251985	Nuclear signaling by ERBB4	0.097776	1.010
R-HSA-5632684	Hedgehog 'on' state	0.221221	0.655
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	0.209344	0.679
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.252383	0.598
R-HSA-9031628	NGF-stimulated transcription	0.025508	1.593
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.300964	0.521
R-HSA-212165	Epigenetic regulation of gene expression	0.187614	0.727
R-HSA-9664873	Pexophagy	0.135300	0.869
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.084189	1.075
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.192901	0.715
R-HSA-69052	Switching of origins to a post-replicative state	0.229414	0.639
R-HSA-8934903	Receptor Mediated Mitophagy	0.135300	0.869
R-HSA-205043	NRIF signals cell death from the nucleus	0.182347	0.739
R-HSA-69278	Cell Cycle, Mitotic	0.123959	0.907
R-HSA-5358351	Signaling by Hedgehog	0.251059	0.600
R-HSA-69206	G1/S Transition	0.073215	1.135
R-HSA-6794362	Protein-protein interactions at synapses	0.278831	0.555
R-HSA-1632852	Macroautophagy	0.260017	0.585
R-HSA-201681	TCF dependent signaling in response to WNT	0.077666	1.110
R-HSA-1640170	Cell Cycle	0.194687	0.711
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.125573	0.901
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.154434	0.811
R-HSA-8951936	RUNX3 regulates p14-ARF	0.163842	0.786
R-HSA-69109	Leading Strand Synthesis	0.163842	0.786
R-HSA-69091	Polymerase switching	0.163842	0.786
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.061461	1.211
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	0.260707	0.584
R-HSA-429947	Deadenylation of mRNA	0.285130	0.545
R-HSA-9839394	TGFBR3 expression	0.293091	0.533
R-HSA-9663891	Selective autophagy	0.095885	1.018
R-HSA-1236394	Signaling by ERBB4	0.233518	0.632
R-HSA-74158	RNA Polymerase III Transcription	0.084189	1.075
R-HSA-9662834	CD163 mediating an anti-inflammatory response	0.144920	0.839
R-HSA-9612973	Autophagy	0.308351	0.511
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.018337	1.737
R-HSA-68882	Mitotic Anaphase	0.271702	0.566
R-HSA-5205647	Mitophagy	0.077632	1.110
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.274164	0.562
R-HSA-5619507	Activation of HOX genes during differentiation	0.042150	1.375
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.042150	1.375
R-HSA-195721	Signaling by WNT	0.147728	0.831
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.163842	0.786
R-HSA-9697154	Disorders of Nervous System Development	0.163842	0.786
R-HSA-9005895	Pervasive developmental disorders	0.163842	0.786
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.191446	0.718
R-HSA-69202	Cyclin E associated events during G1/S transition	0.057872	1.238
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.277079	0.557
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.277079	0.557
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	0.300964	0.521
R-HSA-8943724	Regulation of PTEN gene transcription	0.176764	0.753
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.080831	1.092
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.154574	0.811
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.274709	0.561
R-HSA-1592230	Mitochondrial biogenesis	0.060485	1.218
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	0.308750	0.510
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.070876	1.150
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.209344	0.679
R-HSA-8878171	Transcriptional regulation by RUNX1	0.059368	1.226
R-HSA-5689603	UCH proteinases	0.241739	0.617
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu...	0.038557	1.414
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptor...	0.023504	1.629
R-HSA-9675151	Disorders of Developmental Biology	0.209344	0.679
R-HSA-912526	Interleukin receptor SHC signaling	0.277079	0.557
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.293091	0.533
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.300964	0.521
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.184748	0.733
R-HSA-9909396	Circadian clock	0.230357	0.638
R-HSA-68886	M Phase	0.296792	0.528
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.061461	1.211
R-HSA-9932444	ATP-dependent chromatin remodelers	0.293091	0.533
R-HSA-9932451	SWI/SNF chromatin remodelers	0.293091	0.533
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.068124	1.167
R-HSA-2559583	Cellular Senescence	0.184510	0.734
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	0.135300	0.869
R-HSA-210990	PECAM1 interactions	0.144920	0.839
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.057872	1.238
R-HSA-525793	Myogenesis	0.300964	0.521
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.176764	0.753
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.198563	0.702
R-HSA-69620	Cell Cycle Checkpoints	0.093357	1.030
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.282952	0.548
R-HSA-75893	TNF signaling	0.035721	1.447
R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.027789	1.556
R-HSA-2028269	Signaling by Hippo	0.218144	0.661
R-HSA-3214847	HATs acetylate histones	0.126405	0.898
R-HSA-5688426	Deubiquitination	0.195932	0.708
R-HSA-186763	Downstream signal transduction	0.065047	1.187
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.204918	0.688
R-HSA-8878166	Transcriptional regulation by RUNX2	0.017478	1.758
R-HSA-5357905	Regulation of TNFR1 signaling	0.023240	1.634
R-HSA-74160	Gene expression (Transcription)	0.166806	0.778
R-HSA-3214842	HDMs demethylate histones	0.293091	0.533
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.215778	0.666
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.067967	1.168
R-HSA-5635838	Activation of SMO	0.200445	0.698
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.218144	0.661
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specif...	0.039728	1.401
R-HSA-8939902	Regulation of RUNX2 expression and activity	0.180749	0.743
R-HSA-9762292	Regulation of CDH11 function	0.135300	0.869
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.037208	1.429
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.218144	0.661
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.160974	0.793
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.061836	1.209
R-HSA-4839726	Chromatin organization	0.082911	1.081
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	0.130306	0.885
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.037208	1.429
R-HSA-8953750	Transcriptional Regulation by E2F6	0.094323	1.025
R-HSA-9856532	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	0.235454	0.628
R-HSA-73857	RNA Polymerase II Transcription	0.207197	0.684
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.308750	0.510
R-HSA-3247509	Chromatin modifying enzymes	0.157014	0.804
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.149311	0.826
R-HSA-212436	Generic Transcription Pathway	0.162059	0.790
R-HSA-166520	Signaling by NTRKs	0.284092	0.547
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.221117	0.655
R-HSA-210993	Tie2 Signaling	0.226847	0.644
R-HSA-9700206	Signaling by ALK in cancer	0.149311	0.826
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.115549	0.937
R-HSA-1257604	PIP3 activates AKT signaling	0.065010	1.187
R-HSA-416482	G alpha (12/13) signalling events	0.016399	1.785
R-HSA-156711	Polo-like kinase mediated events	0.226847	0.644
R-HSA-186797	Signaling by PDGF	0.184748	0.733
R-HSA-418990	Adherens junctions interactions	0.276630	0.558
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.184748	0.733
R-HSA-8983432	Interleukin-15 signaling	0.163842	0.786
R-HSA-5358508	Mismatch Repair	0.226847	0.644
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.134061	0.873
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.277079	0.557
R-HSA-9006925	Intracellular signaling by second messengers	0.113193	0.946
R-HSA-9682706	Replication of the SARS-CoV-1 genome	0.173146	0.762
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.176764	0.753
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.176764	0.753
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.176764	0.753
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.176764	0.753
R-HSA-9614085	FOXO-mediated transcription	0.035843	1.446
R-HSA-9694686	Replication of the SARS-CoV-2 genome	0.218144	0.661
R-HSA-9707564	Cytoprotection by HMOX1	0.270586	0.568
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.211782	0.674
R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	0.182347	0.739
R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	0.235454	0.628
R-HSA-451927	Interleukin-2 family signaling	0.097776	1.010
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.237626	0.624
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.176764	0.753
R-HSA-1980143	Signaling by NOTCH1	0.241739	0.617
R-HSA-167287	HIV elongation arrest and recovery	0.316450	0.500
R-HSA-167290	Pausing and recovery of HIV elongation	0.316450	0.500
R-HSA-171319	Telomere Extension By Telomerase	0.316450	0.500
R-HSA-113418	Formation of the Early Elongation Complex	0.316450	0.500
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.316450	0.500
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.316450	0.500
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	0.316450	0.500
R-HSA-68867	Assembly of the pre-replicative complex	0.319894	0.495
R-HSA-9006936	Signaling by TGFB family members	0.320515	0.494
R-HSA-72086	mRNA Capping	0.324064	0.489
R-HSA-5656169	Termination of translesion DNA synthesis	0.324064	0.489
R-HSA-9759475	Regulation of CDH11 Expression and Function	0.324064	0.489
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.328050	0.484
R-HSA-68962	Activation of the pre-replicative complex	0.331594	0.479
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.331594	0.479
R-HSA-1852241	Organelle biogenesis and maintenance	0.331837	0.479
R-HSA-5694530	Cargo concentration in the ER	0.339041	0.470
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	0.339041	0.470
R-HSA-157579	Telomere Maintenance	0.340235	0.468
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.340235	0.468
R-HSA-1538133	G0 and Early G1	0.346405	0.460
R-HSA-5610787	Hedgehog 'off' state	0.352351	0.453
R-HSA-9930044	Nuclear RNA decay	0.353688	0.451
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.353688	0.451
R-HSA-1839124	FGFR1 mutant receptor activation	0.353688	0.451
R-HSA-176187	Activation of ATR in response to replication stress	0.353688	0.451
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	0.353688	0.451
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.353688	0.451
R-HSA-354192	Integrin signaling	0.353688	0.451
R-HSA-159418	Recycling of bile acids and salts	0.353688	0.451
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	0.353688	0.451
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.353688	0.451
R-HSA-9022692	Regulation of MECP2 expression and activity	0.353688	0.451
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	0.353688	0.451
R-HSA-421270	Cell-cell junction organization	0.359371	0.444
R-HSA-1483255	PI Metabolism	0.360386	0.443
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.360889	0.443
R-HSA-5693537	Resolution of D-Loop Structures	0.360889	0.443
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.360889	0.443
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.363057	0.440
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.363057	0.440
R-HSA-5696400	Dual Incision in GG-NER	0.368012	0.434
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.368012	0.434
R-HSA-5673000	RAF activation	0.368012	0.434
R-HSA-168638	NOD1/2 Signaling Pathway	0.368012	0.434
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	0.368012	0.434
R-HSA-9833110	RSV-host interactions	0.372370	0.429
R-HSA-2559585	Oncogene Induced Senescence	0.375055	0.426
R-HSA-69205	G1/S-Specific Transcription	0.382020	0.418
R-HSA-8853659	RET signaling	0.382020	0.418
R-HSA-4641257	Degradation of AXIN	0.388908	0.410
R-HSA-419037	NCAM1 interactions	0.388908	0.410
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.388908	0.410
R-HSA-9734767	Developmental Cell Lineages	0.389640	0.409
R-HSA-69002	DNA Replication Pre-Initiation	0.392140	0.407
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.395719	0.403
R-HSA-8875878	MET promotes cell motility	0.395719	0.403
R-HSA-9711123	Cellular response to chemical stress	0.402205	0.396
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.402455	0.395
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.409116	0.388
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.409116	0.388
R-HSA-167169	HIV Transcription Elongation	0.409116	0.388
R-HSA-9646399	Aggrephagy	0.409116	0.388
R-HSA-177243	Interactions of Rev with host cellular proteins	0.409116	0.388
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.411627	0.385
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.414472	0.383
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.415704	0.381
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.415704	0.381
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.415704	0.381
R-HSA-8853884	Transcriptional Regulation by VENTX	0.415704	0.381
R-HSA-5610783	Degradation of GLI2 by the proteasome	0.422218	0.374
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.422218	0.374
R-HSA-5655302	Signaling by FGFR1 in disease	0.422218	0.374
R-HSA-6811438	Intra-Golgi traffic	0.422218	0.374
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	0.422218	0.374
R-HSA-68877	Mitotic Prometaphase	0.423009	0.374
R-HSA-446728	Cell junction organization	0.427191	0.369
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.428660	0.368
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.428660	0.368
R-HSA-9007101	Rab regulation of trafficking	0.430806	0.366
R-HSA-5693538	Homology Directed Repair	0.434602	0.362
R-HSA-8854214	TBC/RABGAPs	0.435031	0.361
R-HSA-1433557	Signaling by SCF-KIT	0.435031	0.361
R-HSA-373752	Netrin-1 signaling	0.441331	0.355
R-HSA-73886	Chromosome Maintenance	0.445909	0.351
R-HSA-9759194	Nuclear events mediated by NFE2L2	0.445909	0.351
R-HSA-6783310	Fanconi Anemia Pathway	0.447562	0.349
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.447562	0.349
R-HSA-72165	mRNA Splicing - Minor Pathway	0.453723	0.343
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.453723	0.343
R-HSA-2299718	Condensation of Prophase Chromosomes	0.453723	0.343
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.453723	0.343
R-HSA-9649948	Signaling downstream of RAS mutants	0.453723	0.343
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.453723	0.343
R-HSA-6802949	Signaling by RAS mutants	0.453723	0.343
R-HSA-9839373	Signaling by TGFBR3	0.453723	0.343
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.459816	0.337
R-HSA-69481	G2/M Checkpoints	0.471795	0.326
R-HSA-72187	mRNA 3'-end processing	0.489281	0.310
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.489281	0.310
R-HSA-112382	Formation of RNA Pol II elongation complex	0.489281	0.310
R-HSA-73772	RNA Polymerase I Promoter Escape	0.489281	0.310
R-HSA-68949	Orc1 removal from chromatin	0.489281	0.310
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	0.494979	0.305
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.494979	0.305
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.494979	0.305
R-HSA-445355	Smooth Muscle Contraction	0.494979	0.305
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.500614	0.300
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.506187	0.296
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.506187	0.296
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.511697	0.291
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.511697	0.291
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.511697	0.291
R-HSA-9675108	Nervous system development	0.513108	0.290
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.514444	0.289
R-HSA-5621480	Dectin-2 family	0.517147	0.286
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.517147	0.286
R-HSA-1500931	Cell-Cell communication	0.519081	0.285
R-HSA-6807070	PTEN Regulation	0.521330	0.283
R-HSA-6782135	Dual incision in TC-NER	0.522536	0.282
R-HSA-9772572	Early SARS-CoV-2 Infection Events	0.522536	0.282
R-HSA-1227986	Signaling by ERBB2	0.533136	0.273
R-HSA-1266738	Developmental Biology	0.533793	0.273
R-HSA-162599	Late Phase of HIV Life Cycle	0.534906	0.272
R-HSA-8856828	Clathrin-mediated endocytosis	0.538259	0.269
R-HSA-73856	RNA Polymerase II Transcription Termination	0.538347	0.269
R-HSA-211976	Endogenous sterols	0.538347	0.269
R-HSA-1442490	Collagen degradation	0.538347	0.269
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.543501	0.265
R-HSA-375165	NCAM signaling for neurite out-growth	0.543501	0.265
R-HSA-109582	Hemostasis	0.547511	0.262
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.548597	0.261
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.548597	0.261
R-HSA-8848021	Signaling by PTK6	0.548597	0.261
R-HSA-202733	Cell surface interactions at the vascular wall	0.549346	0.260
R-HSA-199977	ER to Golgi Anterograde Transport	0.551504	0.258
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.553637	0.257
R-HSA-9856651	MITF-M-dependent gene expression	0.561263	0.251
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.564482	0.248
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.567684	0.246
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.568424	0.245
R-HSA-5693532	DNA Double-Strand Break Repair	0.570870	0.243
R-HSA-913709	O-linked glycosylation of mucins	0.573244	0.242
R-HSA-167172	Transcription of the HIV genome	0.573244	0.242
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.573244	0.242
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.573244	0.242
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	0.573244	0.242
R-HSA-162587	HIV Life Cycle	0.583442	0.234
R-HSA-449147	Signaling by Interleukins	0.586284	0.232
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.587384	0.231
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.587384	0.231
R-HSA-427413	NoRC negatively regulates rRNA expression	0.587384	0.231
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.596551	0.224
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.601059	0.221
R-HSA-69473	G2/M DNA damage checkpoint	0.601059	0.221
R-HSA-1226099	Signaling by FGFR in disease	0.601059	0.221
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.605516	0.218
R-HSA-422475	Axon guidance	0.608876	0.215
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.609924	0.215
R-HSA-2262752	Cellular responses to stress	0.617070	0.210
R-HSA-73864	RNA Polymerase I Transcription	0.618593	0.209
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.618593	0.209
R-HSA-9659379	Sensory processing of sound	0.622855	0.206
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.622855	0.206
R-HSA-199991	Membrane Trafficking	0.623165	0.205
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.627070	0.203
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.627070	0.203
R-HSA-6806834	Signaling by MET	0.627070	0.203
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.635360	0.197
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.635360	0.197
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.643467	0.191
R-HSA-6802957	Oncogenic MAPK signaling	0.647453	0.189
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.655292	0.184
R-HSA-8953897	Cellular responses to stimuli	0.658003	0.182
R-HSA-438064	Post NMDA receptor activation events	0.659147	0.181
R-HSA-390466	Chaperonin-mediated protein folding	0.659147	0.181
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.670455	0.174
R-HSA-73884	Base Excision Repair	0.670455	0.174
R-HSA-202424	Downstream TCR signaling	0.670455	0.174
R-HSA-5673001	RAF/MAP kinase cascade	0.673220	0.172
R-HSA-8986944	Transcriptional Regulation by MECP2	0.674141	0.171
R-HSA-391251	Protein folding	0.681390	0.167
R-HSA-5684996	MAPK1/MAPK3 signaling	0.687847	0.163
R-HSA-72163	mRNA Splicing - Major Pathway	0.689405	0.162
R-HSA-9609690	HCMV Early Events	0.694320	0.158
R-HSA-6807878	COPI-mediated anterograde transport	0.698818	0.156
R-HSA-8878159	Transcriptional regulation by RUNX3	0.702189	0.154
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.703959	0.152
R-HSA-422356	Regulation of insulin secretion	0.705521	0.151
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.705521	0.151
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.705521	0.151
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.705521	0.151
R-HSA-948021	Transport to the Golgi and subsequent modification	0.708683	0.150
R-HSA-192105	Synthesis of bile acids and bile salts	0.708817	0.149
R-HSA-9020702	Interleukin-1 signaling	0.715299	0.146
R-HSA-72172	mRNA Splicing	0.715652	0.145
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.718486	0.144
R-HSA-2559580	Oxidative Stress Induced Senescence	0.718486	0.144
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.724753	0.140
R-HSA-5696398	Nucleotide Excision Repair	0.730882	0.136
R-HSA-9730414	MITF-M-regulated melanocyte development	0.735729	0.133
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.739822	0.131
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.742735	0.129
R-HSA-194068	Bile acid and bile salt metabolism	0.745617	0.127
R-HSA-202403	TCR signaling	0.745617	0.127
R-HSA-2871796	FCERI mediated MAPK activation	0.751283	0.124
R-HSA-1483249	Inositol phosphate metabolism	0.751283	0.124
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.754070	0.123
R-HSA-9855142	Cellular responses to mechanical stimuli	0.756825	0.121
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.762243	0.118
R-HSA-162906	HIV Infection	0.764565	0.117
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.764907	0.116
R-HSA-72737	Cap-dependent Translation Initiation	0.767541	0.115
R-HSA-72613	Eukaryotic Translation Initiation	0.767541	0.115
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.775269	0.111
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.775269	0.111
R-HSA-68875	Mitotic Prophase	0.777788	0.109
R-HSA-5683057	MAPK family signaling cascades	0.779876	0.108
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.782742	0.106
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.782742	0.106
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.785178	0.105
R-HSA-2132295	MHC class II antigen presentation	0.785178	0.105
R-HSA-162909	Host Interactions of HIV factors	0.787586	0.104
R-HSA-157118	Signaling by NOTCH	0.788871	0.103
R-HSA-194138	Signaling by VEGF	0.792322	0.101
R-HSA-3700989	Transcriptional Regulation by TP53	0.794878	0.100
R-HSA-73894	DNA Repair	0.799438	0.097
R-HSA-9609646	HCMV Infection	0.806045	0.094
R-HSA-8856688	Golgi-to-ER retrograde transport	0.810241	0.091
R-HSA-1474228	Degradation of the extracellular matrix	0.810241	0.091
R-HSA-163685	Integration of energy metabolism	0.820650	0.086
R-HSA-5173105	O-linked glycosylation	0.822663	0.085
R-HSA-5653656	Vesicle-mediated transport	0.823573	0.084
R-HSA-9664422	FCGR3A-mediated phagocytosis	0.828567	0.082
R-HSA-9664407	Parasite infection	0.828567	0.082
R-HSA-9664417	Leishmania phagocytosis	0.828567	0.082
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.830491	0.081
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.845132	0.073
R-HSA-9679191	Potential therapeutics for SARS	0.848592	0.071
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.849050	0.071
R-HSA-9824443	Parasitic Infection Pathways	0.851672	0.070
R-HSA-9658195	Leishmania infection	0.851672	0.070
R-HSA-446652	Interleukin-1 family signaling	0.851974	0.070
R-HSA-597592	Post-translational protein modification	0.852718	0.069
R-HSA-1483257	Phospholipid metabolism	0.868902	0.061
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.875058	0.058
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.880584	0.055
R-HSA-5621481	C-type lectin receptors (CLRs)	0.881928	0.055
R-HSA-9664433	Leishmania parasite growth and survival	0.884569	0.053
R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	0.884569	0.053
R-HSA-5689880	Ub-specific processing proteases	0.884569	0.053
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.885867	0.053
R-HSA-9678108	SARS-CoV-1 Infection	0.887151	0.052
R-HSA-112315	Transmission across Chemical Synapses	0.897990	0.047
R-HSA-3781865	Diseases of glycosylation	0.898080	0.047
R-HSA-69275	G2/M Transition	0.900362	0.046
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.902593	0.045
R-HSA-453274	Mitotic G2-G2/M phases	0.902593	0.045
R-HSA-5617833	Cilium Assembly	0.904774	0.043
R-HSA-168898	Toll-like Receptor Cascades	0.905847	0.043
R-HSA-112316	Neuronal System	0.912840	0.040
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.917816	0.037
R-HSA-8953854	Metabolism of RNA	0.920436	0.036
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.926625	0.033
R-HSA-397014	Muscle contraction	0.926625	0.033
R-HSA-8951664	Neddylation	0.933747	0.030
R-HSA-72312	rRNA processing	0.941524	0.026
R-HSA-388396	GPCR downstream signalling	0.945421	0.024
R-HSA-9824446	Viral Infection Pathways	0.947396	0.023
R-HSA-446203	Asparagine N-linked glycosylation	0.959816	0.018
R-HSA-76002	Platelet activation, signaling and aggregation	0.963728	0.016
R-HSA-1280215	Cytokine Signaling in Immune system	0.964689	0.016
R-HSA-211945	Phase I - Functionalization of compounds	0.965343	0.015
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.966887	0.015
R-HSA-372790	Signaling by GPCR	0.970348	0.013
R-HSA-1643685	Disease	0.970919	0.013
R-HSA-6798695	Neutrophil degranulation	0.971310	0.013
R-HSA-8957322	Metabolism of steroids	0.979491	0.009
R-HSA-1474244	Extracellular matrix organization	0.981068	0.008
R-HSA-9694516	SARS-CoV-2 Infection	0.984589	0.007
R-HSA-9679506	SARS-CoV Infections	0.989092	0.005
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.989679	0.005
R-HSA-392499	Metabolism of proteins	0.990350	0.004
R-HSA-418594	G alpha (i) signalling events	0.992163	0.003
R-HSA-5668914	Diseases of metabolism	0.993772	0.003
R-HSA-72766	Translation	0.993914	0.003
R-HSA-5663205	Infectious disease	0.994122	0.003
R-HSA-211859	Biological oxidations	0.997942	0.001
R-HSA-168249	Innate Immune System	0.998084	0.001
R-HSA-556833	Metabolism of lipids	0.999519	0.000
R-HSA-1280218	Adaptive Immune System	0.999585	0.000
R-HSA-168256	Immune System	0.999977	0.000
R-HSA-9709957	Sensory Perception	1.000000	0.000
R-HSA-1430728	Metabolism	1.000000	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
HIPK2	0.823	0.681	1	0.877
CDK18	0.821	0.699	1	0.890
KIS	0.818	0.638	1	0.829
CDK17	0.815	0.695	1	0.908
CDK19	0.810	0.663	1	0.867
P38G	0.807	0.687	1	0.916
CDK7	0.804	0.669	1	0.849
ERK1	0.804	0.674	1	0.881
CDK16	0.802	0.651	1	0.900
DYRK2	0.802	0.643	1	0.807
CDK3	0.802	0.587	1	0.906
P38D	0.801	0.679	1	0.919
CDK1	0.801	0.649	1	0.872
JNK2	0.801	0.695	1	0.883
P38B	0.801	0.687	1	0.870
CDK8	0.801	0.654	1	0.836
CDK14	0.799	0.659	1	0.855
CDK13	0.798	0.653	1	0.868
CDK12	0.798	0.652	1	0.883
DYRK4	0.797	0.635	1	0.886
HIPK4	0.796	0.537	1	0.610
CDK10	0.796	0.615	1	0.870
HIPK1	0.795	0.601	1	0.790
CDK5	0.793	0.640	1	0.828
JNK3	0.790	0.675	1	0.862
P38A	0.788	0.657	1	0.812
CDK9	0.786	0.633	1	0.864
DYRK1B	0.786	0.595	1	0.847
HIPK3	0.784	0.583	1	0.759
CLK3	0.783	0.454	1	0.580
DYRK1A	0.781	0.531	1	0.765
MAK	0.781	0.503	-2	0.816
ERK2	0.780	0.637	1	0.840
SRPK1	0.776	0.328	-3	0.769
CDK4	0.776	0.632	1	0.889
JNK1	0.775	0.609	1	0.881
CDK6	0.775	0.610	1	0.869
NLK	0.774	0.585	1	0.612
DYRK3	0.773	0.472	1	0.754
ERK5	0.770	0.383	1	0.553
SRPK2	0.765	0.284	-3	0.701
ICK	0.762	0.377	-3	0.843
CLK2	0.762	0.356	-3	0.743
CDKL5	0.761	0.219	-3	0.808
CLK1	0.760	0.344	-3	0.727
MOK	0.758	0.425	1	0.702
CDK2	0.758	0.444	1	0.761
CLK4	0.757	0.327	-3	0.751
MTOR	0.755	0.200	1	0.414
CDKL1	0.751	0.186	-3	0.813
SRPK3	0.751	0.224	-3	0.747
PRP4	0.748	0.394	-3	0.758
COT	0.744	-0.008	2	0.868
NDR2	0.742	0.095	-3	0.835
MOS	0.742	0.078	1	0.297
ERK7	0.740	0.259	2	0.641
CDC7	0.740	-0.032	1	0.250
AURC	0.738	0.096	-2	0.649
ATR	0.737	0.004	1	0.295
PIM3	0.737	0.044	-3	0.832
PRKD1	0.735	0.043	-3	0.828
SKMLCK	0.733	0.059	-2	0.828
PRPK	0.733	-0.024	-1	0.839
TBK1	0.732	-0.083	1	0.199
PRKD2	0.731	0.036	-3	0.776
NEK6	0.730	-0.003	-2	0.762
GRK1	0.729	0.083	-2	0.758
WNK1	0.729	-0.047	-2	0.817
PKN3	0.729	0.004	-3	0.820
P90RSK	0.729	0.041	-3	0.783
RSK2	0.728	0.031	-3	0.774
PKCD	0.728	0.041	2	0.828
NDR1	0.728	-0.004	-3	0.815
GCN2	0.728	-0.135	2	0.823
CHAK2	0.728	0.008	-1	0.821
TGFBR2	0.727	-0.037	-2	0.726
RSK3	0.727	0.025	-3	0.766
NUAK2	0.727	0.016	-3	0.817
IKKB	0.726	-0.100	-2	0.670
MNK2	0.726	0.051	-2	0.746
RIPK3	0.726	-0.080	3	0.666
IKKE	0.726	-0.106	1	0.195
MPSK1	0.726	0.149	1	0.311
PKCA	0.726	0.069	2	0.790
MLK2	0.726	0.052	2	0.842
CAMLCK	0.726	0.038	-2	0.801
PDHK4	0.726	-0.135	1	0.301
MST4	0.725	-0.030	2	0.885
CAMK1B	0.725	-0.024	-3	0.827
BMPR2	0.725	-0.084	-2	0.797
ULK2	0.725	-0.108	2	0.816
RAF1	0.725	-0.158	1	0.235
PKN2	0.724	-0.028	-3	0.803
NIK	0.724	-0.009	-3	0.836
PHKG1	0.724	0.013	-3	0.802
DAPK2	0.724	0.026	-3	0.838
IRE1	0.724	-0.038	1	0.245
GRK7	0.724	0.084	1	0.261
MLK3	0.724	0.040	2	0.790
PKCB	0.722	0.028	2	0.790
PKCZ	0.722	0.041	2	0.831
PKACG	0.722	0.008	-2	0.696
PIM1	0.722	0.038	-3	0.781
MNK1	0.722	0.040	-2	0.748
PKCG	0.721	0.019	2	0.790
MLK1	0.720	-0.091	2	0.853
LATS2	0.720	0.009	-5	0.728
IKKA	0.719	-0.013	-2	0.670
MAPKAPK3	0.719	-0.016	-3	0.771
DSTYK	0.719	-0.141	2	0.876
NEK7	0.719	-0.133	-3	0.837
RSK4	0.719	0.058	-3	0.761
PDHK1	0.719	-0.126	1	0.275
PKACB	0.718	0.059	-2	0.654
PRKD3	0.718	0.013	-3	0.736
PKG2	0.717	0.037	-2	0.644
AMPKA1	0.717	-0.033	-3	0.823
AKT2	0.717	0.063	-3	0.694
NEK9	0.717	-0.083	2	0.871
PAK1	0.717	0.011	-2	0.774
BUB1	0.716	0.151	-5	0.803
MASTL	0.716	-0.101	-2	0.730
PAK3	0.716	-0.006	-2	0.757
P70S6KB	0.716	0.004	-3	0.778
MAPKAPK2	0.716	0.007	-3	0.741
AURB	0.716	0.027	-2	0.646
GRK5	0.716	-0.099	-3	0.802
PAK6	0.715	0.024	-2	0.683
ULK1	0.715	-0.104	-3	0.799
AMPKA2	0.715	-0.007	-3	0.798
SMG1	0.715	-0.033	1	0.279
LATS1	0.714	0.064	-3	0.844
IRE2	0.714	-0.043	2	0.813
SGK3	0.713	0.033	-3	0.749
GSK3A	0.713	0.150	4	0.365
PKCH	0.713	-0.008	2	0.784
RIPK1	0.713	-0.126	1	0.232
WNK3	0.712	-0.173	1	0.235
VRK2	0.712	0.113	1	0.341
BMPR1B	0.712	-0.035	1	0.220
CAMK2D	0.712	-0.051	-3	0.822
DLK	0.712	-0.108	1	0.242
MSK2	0.712	0.004	-3	0.762
BCKDK	0.711	-0.120	-1	0.752
CAMK2G	0.711	-0.129	2	0.766
NUAK1	0.711	-0.018	-3	0.768
PINK1	0.710	0.098	1	0.447
MELK	0.710	-0.033	-3	0.777
TSSK1	0.710	-0.059	-3	0.841
MARK4	0.710	-0.074	4	0.754
ALK4	0.709	-0.041	-2	0.768
HUNK	0.709	-0.164	2	0.835
NIM1	0.709	-0.076	3	0.653
MSK1	0.708	0.023	-3	0.754
PRKX	0.708	0.051	-3	0.677
PKR	0.708	-0.053	1	0.261
DNAPK	0.708	-0.038	1	0.269
ANKRD3	0.708	-0.140	1	0.254
PIM2	0.708	0.032	-3	0.739
YSK4	0.707	-0.079	1	0.213
NEK2	0.707	-0.069	2	0.858
TTBK2	0.707	-0.154	2	0.722
PAK2	0.707	-0.024	-2	0.751
MLK4	0.707	-0.048	2	0.773
PKCT	0.707	0.003	2	0.788
CAMK4	0.706	-0.090	-3	0.783
AKT1	0.706	0.044	-3	0.708
TGFBR1	0.706	-0.036	-2	0.746
MYLK4	0.705	-0.012	-2	0.743
MST3	0.705	-0.012	2	0.882
ATM	0.705	-0.084	1	0.255
CK1E	0.705	-0.014	-3	0.537
TLK2	0.704	-0.060	1	0.221
CAMK2A	0.703	0.002	2	0.739
IRAK4	0.703	-0.059	1	0.225
PKCE	0.703	0.030	2	0.788
CHAK1	0.703	-0.114	2	0.806
AKT3	0.703	0.067	-3	0.653
NEK5	0.702	-0.031	1	0.242
TSSK2	0.702	-0.123	-5	0.849
PKCI	0.702	0.002	2	0.817
PLK4	0.702	-0.065	2	0.665
GRK6	0.702	-0.146	1	0.230
PASK	0.702	0.032	-3	0.859
QSK	0.701	-0.035	4	0.743
AURA	0.701	0.004	-2	0.637
GRK4	0.701	-0.143	-2	0.764
DCAMKL1	0.701	-0.014	-3	0.763
LKB1	0.701	0.066	-3	0.821
CK1D	0.700	0.006	-3	0.491
PAK5	0.700	0.004	-2	0.638
PKACA	0.700	0.033	-2	0.607
QIK	0.699	-0.111	-3	0.800
TAO3	0.699	0.008	1	0.260
MAPKAPK5	0.699	-0.058	-3	0.736
ACVR2B	0.699	-0.082	-2	0.724
MEK1	0.699	-0.140	2	0.843
WNK4	0.699	-0.097	-2	0.801
SIK	0.699	-0.037	-3	0.742
PAK4	0.699	0.013	-2	0.652
BRSK2	0.698	-0.049	-3	0.781
DRAK1	0.698	-0.102	1	0.203
MEK5	0.698	-0.103	2	0.842
MAP3K15	0.698	0.024	1	0.231
ACVR2A	0.698	-0.091	-2	0.708
PERK	0.697	-0.099	-2	0.740
PDK1	0.697	-0.000	1	0.266
CAMK2B	0.696	-0.062	2	0.711
CAMK1G	0.696	-0.056	-3	0.755
PHKG2	0.696	-0.073	-3	0.751
CK1G1	0.696	-0.047	-3	0.520
GRK2	0.695	-0.080	-2	0.672
ZAK	0.695	-0.105	1	0.217
NEK11	0.695	-0.066	1	0.252
PLK1	0.695	-0.151	-2	0.712
GSK3B	0.695	0.023	4	0.363
SMMLCK	0.695	-0.019	-3	0.799
PKN1	0.694	-0.004	-3	0.716
MEKK2	0.694	-0.082	2	0.829
MEKK6	0.694	-0.042	1	0.249
CK1A2	0.694	-0.021	-3	0.490
MEKK1	0.694	-0.115	1	0.238
GCK	0.694	0.015	1	0.242
SGK1	0.692	0.061	-3	0.630
PBK	0.692	0.027	1	0.285
BRSK1	0.692	-0.048	-3	0.772
ALK2	0.692	-0.089	-2	0.750
HASPIN	0.692	0.047	-1	0.741
ROCK2	0.691	0.047	-3	0.764
DCAMKL2	0.691	-0.040	-3	0.774
SNRK	0.691	-0.139	2	0.710
P70S6K	0.691	-0.017	-3	0.707
CHK1	0.691	-0.074	-3	0.792
NEK8	0.690	-0.088	2	0.859
HRI	0.690	-0.159	-2	0.751
MEKK3	0.690	-0.160	1	0.237
MRCKB	0.689	0.026	-3	0.720
HPK1	0.689	-0.025	1	0.243
BRAF	0.689	-0.109	-4	0.403
GAK	0.689	-0.051	1	0.306
KHS1	0.689	0.020	1	0.236
MARK3	0.688	-0.066	4	0.683
HGK	0.688	-0.028	3	0.790
NEK4	0.688	-0.077	1	0.223
DAPK3	0.688	-0.007	-3	0.783
TNIK	0.688	0.001	3	0.788
TAO2	0.687	-0.046	2	0.873
LOK	0.687	-0.005	-2	0.671
BMPR1A	0.687	-0.075	1	0.200
KHS2	0.687	0.020	1	0.248
SBK	0.686	0.094	-3	0.594
SSTK	0.686	-0.085	4	0.742
LRRK2	0.686	0.014	2	0.876
NEK1	0.686	-0.035	1	0.222
FAM20C	0.685	-0.071	2	0.516
SLK	0.685	0.014	-2	0.626
CAMKK2	0.684	-0.064	-2	0.675
CHK2	0.684	0.001	-3	0.636
MRCKA	0.683	0.012	-3	0.733
MINK	0.683	-0.075	1	0.220
TTBK1	0.682	-0.145	2	0.635
TLK1	0.682	-0.165	-2	0.763
MARK2	0.682	-0.099	4	0.646
DMPK1	0.682	0.041	-3	0.739
GRK3	0.681	-0.084	-2	0.643
EEF2K	0.681	-0.059	3	0.723
DAPK1	0.681	-0.018	-3	0.773
MST2	0.679	-0.102	1	0.227
LIMK2_TYR	0.679	0.193	-3	0.850
CAMKK1	0.679	-0.135	-2	0.677
VRK1	0.678	-0.104	2	0.882
PLK3	0.677	-0.169	2	0.736
PKG1	0.677	-0.011	-2	0.566
CAMK1D	0.677	-0.038	-3	0.676
CRIK	0.677	0.037	-3	0.723
YSK1	0.677	-0.066	2	0.855
MARK1	0.676	-0.118	4	0.705
PDHK3_TYR	0.676	0.145	4	0.823
IRAK1	0.676	-0.206	-1	0.759
CAMK1A	0.675	-0.011	-3	0.659
ROCK1	0.675	0.013	-3	0.729
TAK1	0.674	-0.135	1	0.218
STK33	0.674	-0.100	2	0.628
AAK1	0.674	0.029	1	0.296
NEK3	0.673	-0.085	1	0.235
TESK1_TYR	0.673	0.112	3	0.784
BIKE	0.672	-0.010	1	0.293
PKMYT1_TYR	0.672	0.135	3	0.763
PDHK4_TYR	0.670	0.081	2	0.855
MYO3B	0.670	-0.020	2	0.864
OSR1	0.670	-0.030	2	0.832
MAP2K4_TYR	0.669	0.069	-1	0.840
MST1	0.669	-0.132	1	0.217
MEK2	0.667	-0.153	2	0.827
RIPK2	0.667	-0.189	1	0.193
CK1A	0.666	-0.040	-3	0.405
CK2A2	0.666	-0.105	1	0.191
ASK1	0.665	-0.048	1	0.228
MAP2K6_TYR	0.664	0.029	-1	0.837
TTK	0.664	-0.072	-2	0.743
MAP2K7_TYR	0.664	-0.020	2	0.852
TAO1	0.662	-0.055	1	0.220
TNK2	0.662	0.018	3	0.712
LIMK1_TYR	0.661	0.020	2	0.863
BMPR2_TYR	0.661	-0.016	-1	0.826
MYO3A	0.660	-0.067	1	0.238
MST1R	0.660	-0.016	3	0.747
PDHK1_TYR	0.660	-0.047	-1	0.833
PINK1_TYR	0.660	-0.122	1	0.295
CSF1R	0.659	-0.005	3	0.729
TNK1	0.659	0.045	3	0.699
JAK2	0.659	-0.032	1	0.263
RET	0.659	-0.049	1	0.257
CK2A1	0.658	-0.108	1	0.180
ABL2	0.657	-0.002	-1	0.753
JAK1	0.656	-0.005	1	0.228
TYRO3	0.656	-0.047	3	0.716
EPHB4	0.655	-0.025	-1	0.777
YANK3	0.655	-0.047	2	0.388
ROS1	0.654	-0.062	3	0.685
ABL1	0.654	-0.019	-1	0.748
NEK10_TYR	0.654	-0.038	1	0.224
TXK	0.654	-0.017	1	0.215
TYK2	0.653	-0.132	1	0.245
PLK2	0.653	-0.117	-3	0.716
LCK	0.652	-0.031	-1	0.810
TNNI3K_TYR	0.652	0.002	1	0.270
EPHA6	0.652	-0.055	-1	0.792
FGR	0.650	-0.088	1	0.242
YES1	0.650	-0.070	-1	0.826
KDR	0.650	-0.025	3	0.686
BLK	0.649	-0.037	-1	0.805
ALPHAK3	0.648	-0.090	-1	0.719
HCK	0.648	-0.081	-1	0.810
JAK3	0.647	-0.094	1	0.247
DDR1	0.646	-0.112	4	0.747
MET	0.644	-0.051	3	0.733
TEK	0.644	-0.009	3	0.648
FGFR2	0.644	-0.043	3	0.709
KIT	0.644	-0.084	3	0.727
STLK3	0.643	-0.134	1	0.196
ITK	0.643	-0.083	-1	0.790
FGFR1	0.643	-0.025	3	0.680
WEE1_TYR	0.643	-0.060	-1	0.745
MERTK	0.642	-0.066	3	0.708
PDGFRB	0.641	-0.130	3	0.725
SRMS	0.641	-0.104	1	0.216
FER	0.641	-0.152	1	0.244
AXL	0.641	-0.094	3	0.708
EPHB1	0.641	-0.100	1	0.219
FYN	0.641	-0.046	-1	0.799
PDGFRA	0.640	-0.121	3	0.723
BMX	0.640	-0.064	-1	0.711
FLT3	0.639	-0.149	3	0.721
EPHA4	0.639	-0.069	2	0.738
EPHB3	0.639	-0.100	-1	0.761
CK1G3	0.638	-0.050	-3	0.362
EPHA1	0.638	-0.075	3	0.721
FRK	0.637	-0.092	-1	0.799
INSRR	0.637	-0.144	3	0.655
TEC	0.637	-0.104	-1	0.730
EPHB2	0.637	-0.105	-1	0.750
DDR2	0.636	-0.008	3	0.653
PTK2B	0.636	-0.044	-1	0.753
BTK	0.635	-0.149	-1	0.768
ALK	0.634	-0.102	3	0.633
EPHA7	0.634	-0.069	2	0.751
FGFR3	0.634	-0.058	3	0.680
FLT1	0.633	-0.112	-1	0.745
LYN	0.632	-0.104	3	0.638
SRC	0.630	-0.086	-1	0.787
ERBB2	0.630	-0.140	1	0.220
LTK	0.630	-0.121	3	0.657
PTK6	0.629	-0.140	-1	0.717
MUSK	0.628	-0.082	1	0.181
EPHA3	0.628	-0.106	2	0.719
NTRK2	0.627	-0.153	3	0.679
NTRK3	0.627	-0.104	-1	0.702
NTRK1	0.627	-0.162	-1	0.750
FLT4	0.627	-0.139	3	0.667
ZAP70	0.625	0.009	-1	0.644
MATK	0.625	-0.088	-1	0.666
EGFR	0.623	-0.098	1	0.183
INSR	0.623	-0.146	3	0.641
EPHA8	0.623	-0.097	-1	0.745
CK1G2	0.623	-0.046	-3	0.447
YANK2	0.623	-0.069	2	0.397
PTK2	0.622	-0.055	-1	0.724
SYK	0.622	-0.063	-1	0.701
EPHA5	0.621	-0.110	2	0.720
FGFR4	0.620	-0.094	-1	0.695
CSK	0.619	-0.128	2	0.750
ERBB4	0.617	-0.072	1	0.188
EPHA2	0.614	-0.093	-1	0.699
IGF1R	0.606	-0.152	3	0.573
FES	0.602	-0.125	-1	0.682