Motif 225 (n=139)

Position-wise Probabilities

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uniprot genes site source protein function
A0MZ66 SHTN1 S502 ochoa Shootin-1 (Shootin1) Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.
A1A5D9 BICDL2 S331 ochoa BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) None
E9PAV3 NACA S1581 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
K7ELQ4 ATF7-NPFF S174 ochoa ATF7-NPFF readthrough None
O00139 KIF2A S75 ochoa Kinesin-like protein KIF2A (Kinesin-2) (hK2) Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}.
O00429 DNM1L S616 ochoa|psp Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.
O00512 BCL9 S19 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O00512 BCL9 S294 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O00512 BCL9 S873 ochoa B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}.
O14994 SYN3 S470 ochoa|psp Synapsin-3 (Synapsin III) May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15075 DCLK1 S332 ochoa Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
O15117 FYB1 S209 ochoa FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
O15389 SIGLEC5 S488 ochoa Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
O43314 PPIP5K2 S1180 ochoa Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}.
O43379 WDR62 S33 ochoa|psp WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O43491 EPB41L2 S562 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O75152 ZC3H11A S116 ochoa Zinc finger CCCH domain-containing protein 11A Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.
O75312 ZPR1 S19 ochoa Zinc finger protein ZPR1 (Zinc finger protein 259) Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}.
O75533 SF3B1 S336 ochoa Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
O95359 TACC2 S2557 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
P04626 ERBB2 S1235 ochoa Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.
P06401 PGR S20 ochoa Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
P07197 NEFM S628 ochoa Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}.
P07197 NEFM S667 ochoa Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}.
P07197 NEFM S680 ochoa Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}.
P09543 CNP S318 ochoa 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}.
P15056 BRAF S335 psp Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}.
P21917 DRD4 S245 psp D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}.
P22681 CBL S483 ochoa E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}.
P43403 ZAP70 S301 ochoa Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}.
P49585 PCYT1A S331 ochoa Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}.
P53805 RCAN1 S163 ochoa|psp Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q9JHG6, ECO:0000269|PubMed:12809556}.
P54577 YARS1 S338 ochoa Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}.
P54845 NRL S50 psp Neural retina-specific leucine zipper protein (NRL) Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds to the rhodopsin promoter in a sequence-specific manner (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}.
P55198 MLLT6 S382 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P57682 KLF3 S92 ochoa|psp Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
P78524 DENND2B S413 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
P78559 MAP1A S2617 ochoa|psp Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q02410 APBA1 S313 ochoa Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
Q07157 TJP1 S1051 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q12955 ANK3 S4333 ochoa Ankyrin-3 (ANK-3) (Ankyrin-G) Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.
Q13938 CAPS S40 ochoa Calcyphosin (Calcyphosine) Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}.
Q14135 VGLL4 S139 ochoa Transcription cofactor vestigial-like protein 4 (Vgl-4) May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}.
Q14194 CRMP1 S522 ochoa|psp Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}.
Q14206 RCAN2 S112 ochoa Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Q14244 MAP7 S365 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q15003 NCAPH S589 ochoa Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15772 SPEG S549 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q2NKX8 ERCC6L S739 ochoa DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.
Q2TAZ0 ATG2A S1655 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q4V328 GRIPAP1 S692 ochoa GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}.
Q5JSZ5 PRRC2B S2153 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5M775 SPECC1 S847 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5SNT2 TMEM201 S545 ochoa Transmembrane protein 201 (Spindle-associated membrane protein 1) Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.
Q5SRE5 NUP188 S1717 ochoa Nucleoporin NUP188 (hNup188) Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}.
Q5T035 FAM120A2P S32 ochoa Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) None
Q5T1M5 FKBP15 S1114 ochoa FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}.
Q63HR2 TNS2 S820 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q66K74 MAP1S S569 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q66K74 MAP1S S600 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q68DK7 MSL1 S392 ochoa Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}.
Q68EM7 ARHGAP17 S625 ochoa Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Q6NY19 KANK3 S152 ochoa KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Q6P2E9 EDC4 S768 ochoa Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}.
Q6P3S6 FBXO42 S373 ochoa F-box only protein 42 (Just one F-box and Kelch domain-containing protein) Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.
Q6P3S6 FBXO42 S587 ochoa F-box only protein 42 (Just one F-box and Kelch domain-containing protein) Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}.
Q6PJ61 FBXO46 S21 psp F-box only protein 46 (F-box only protein 34-like) Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}.
Q6PJG2 MIDEAS S636 ochoa Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) None
Q6WKZ4 RAB11FIP1 S1154 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZMT1 STAC2 S78 ochoa SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}.
Q6ZRI6 C15orf39 S108 ochoa Uncharacterized protein C15orf39 None
Q6ZW31 SYDE1 S39 ochoa Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.
Q7Z3K3 POGZ S425 ochoa Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}.
Q7Z3V4 UBE3B S419 ochoa Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes (By similarity). Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC (By similarity). {ECO:0000250|UniProtKB:Q9ES34}.
Q7Z5J4 RAI1 S1110 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q8IVF5 TIAM2 S209 ochoa Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}.
Q8IWU2 LMTK2 S513 ochoa Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) Phosphorylates PPP1C, phosphorylase b and CFTR.
Q8IWY8 ZSCAN29 S153 ochoa Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) May be involved in transcriptional regulation.
Q8IWY9 CDAN1 S265 ochoa Codanin-1 May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}.
Q8IX01 SUGP2 S745 ochoa SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) May play a role in mRNA splicing. {ECO:0000305}.
Q8IYB3 SRRM1 S402 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IZD2 KMT2E S1359 ochoa Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.
Q8N3V7 SYNPO S754 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N3V7 SYNPO S854 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N5Y2 MSL3 S400 ochoa MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}.
Q8N684 CPSF7 S48 ochoa Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}.
Q8NFH8 REPS2 S550 ochoa RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.
Q8WU79 SMAP2 S177 ochoa Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}.
Q8WUM0 NUP133 S45 ochoa|psp Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WUY9 DEPDC1B S436 ochoa DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) None
Q8WV99 ZFAND2B S163 ochoa AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q91X58, ECO:0000269|PubMed:26692333}.
Q8WX93 PALLD S641 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WX93 PALLD S728 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WYP5 AHCTF1 S2120 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q93052 LPP S135 ochoa Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
Q96B54 ZNF428 S99 ochoa Zinc finger protein 428 (Enzyme-like protein PIT13) None
Q96CX2 KCTD12 S171 ochoa BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Q96E39 RBMXL1 S161 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96G01 BICD1 S601 ochoa Protein bicaudal D homolog 1 (Bic-D 1) Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Q96JE9 MAP6 S519 ochoa Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP) Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}.
Q96N21 TEPSIN S413 ochoa AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}.
Q96RY5 CRAMP1 S596 ochoa Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) None
Q96T58 SPEN S3463 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99081 TCF12 S198 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99650 OSMR S943 ochoa Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}.
Q9BRD0 BUD13 S222 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BRP8 PYM1 S64 ochoa Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}.
Q9BVC5 C2orf49 S193 ochoa Ashwin None
Q9BXK1 KLF16 S226 ochoa Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}.
Q9BZL4 PPP1R12C S499 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9C0A6 SETD5 S865 ochoa Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.
Q9C0B5 ZDHHC5 S684 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9H1B7 IRF2BPL T203 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H3P2 NELFA S225 ochoa Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
Q9H3P2 NELFA S327 ochoa Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
Q9H4X1 RGCC S97 ochoa Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
Q9H7D0 DOCK5 S1789 ochoa Dedicator of cytokinesis protein 5 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.
Q9HAW0 BRF2 S353 ochoa Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}.
Q9HCM1 RESF1 S221 ochoa Retroelement silencing factor 1 Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}.
Q9NX95 SYBU S42 ochoa Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}.
Q9NZ72 STMN3 S68 ochoa|psp Stathmin-3 (SCG10-like protein) Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}.
Q9NZB2 FAM120A S383 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9P219 CCDC88C S1444 ochoa Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}.
Q9P2D1 CHD7 S2559 ochoa Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}.
Q9P2J2 IGSF9 S797 ochoa Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}.
Q9UBW5 BIN2 S357 ochoa Bridging integrator 2 (Breast cancer-associated protein 1) Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.
Q9UJF2 RASAL2 S780 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9ULC8 ZDHHC8 S725 ochoa Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.
Q9UM11 FZR1 S146 ochoa Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}.
Q9UPS6 SETD1B S1563 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9Y2H5 PLEKHA6 S336 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y2I7 PIKFYVE S76 ochoa 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}.
Q9Y4D8 HECTD4 S1493 ochoa Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
Q9Y4F5 CEP170B S972 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y566 SHANK1 S2000 ochoa SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Q9Y613 FHOD1 S498 ochoa|psp FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}.
P07814 EPRS1 S1122 Sugiyama Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}.
Q13557 CAMK2D S264 Sugiyama Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
Q96GD4 AURKB S43 Sugiyama Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}.
Download
reactome_id name p -log10_p
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.001073 2.969
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.001567 2.805
R-HSA-141424 Amplification of signal from the kinetochores 0.001567 2.805
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.002359 2.627
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.002984 2.525
R-HSA-69618 Mitotic Spindle Checkpoint 0.003197 2.495
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.005998 2.222
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.005746 2.241
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.004591 2.338
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.006053 2.218
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.007202 2.143
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.008606 2.065
R-HSA-1295596 Spry regulation of FGF signaling 0.012493 1.903
R-HSA-68877 Mitotic Prometaphase 0.011698 1.932
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.009614 2.017
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.034662 1.460
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.034662 1.460
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.034662 1.460
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.034662 1.460
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.034662 1.460
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.034662 1.460
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.034662 1.460
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.034662 1.460
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.034662 1.460
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.034662 1.460
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.034662 1.460
R-HSA-1251932 PLCG1 events in ERBB2 signaling 0.051543 1.288
R-HSA-1306955 GRB7 events in ERBB2 signaling 0.051543 1.288
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.059874 1.223
R-HSA-9706377 FLT3 signaling by CBL mutants 0.059874 1.223
R-HSA-176417 Phosphorylation of Emi1 0.068131 1.167
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.024102 1.618
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.024102 1.618
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.025774 1.589
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.040717 1.390
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.042768 1.369
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.042768 1.369
R-HSA-1855170 IPs transport between nucleus and cytosol 0.046983 1.328
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.046983 1.328
R-HSA-72187 mRNA 3'-end processing 0.016464 1.783
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.049146 1.309
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.053577 1.271
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.062840 1.202
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.065235 1.186
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.017325 1.761
R-HSA-9656223 Signaling by RAF1 mutants 0.070115 1.154
R-HSA-191650 Regulation of gap junction activity 0.051543 1.288
R-HSA-9620244 Long-term potentiation 0.031059 1.508
R-HSA-5673000 RAF activation 0.051344 1.290
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.025774 1.589
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.043140 1.365
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.051543 1.288
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.024102 1.618
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.036732 1.435
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.038705 1.412
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.038705 1.412
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.051344 1.290
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.051344 1.290
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.058143 1.235
R-HSA-73856 RNA Polymerase II Transcription Termination 0.023658 1.626
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.022268 1.652
R-HSA-379716 Cytosolic tRNA aminoacylation 0.072599 1.139
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.046983 1.328
R-HSA-6794361 Neurexins and neuroligins 0.016464 1.783
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.049146 1.309
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.068131 1.167
R-HSA-187706 Signalling to p38 via RIT and RIN 0.068131 1.167
R-HSA-202433 Generation of second messenger molecules 0.065235 1.186
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.046983 1.328
R-HSA-180746 Nuclear import of Rev protein 0.051344 1.290
R-HSA-6784531 tRNA processing in the nucleus 0.024547 1.610
R-HSA-390651 Dopamine receptors 0.051543 1.288
R-HSA-9839394 TGFBR3 expression 0.031059 1.508
R-HSA-177243 Interactions of Rev with host cellular proteins 0.065235 1.186
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.065235 1.186
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.067660 1.170
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.043569 1.361
R-HSA-2467813 Separation of Sister Chromatids 0.023201 1.634
R-HSA-68882 Mitotic Anaphase 0.018804 1.726
R-HSA-6794362 Protein-protein interactions at synapses 0.049849 1.302
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.019152 1.718
R-HSA-68886 M Phase 0.067030 1.174
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.060476 1.218
R-HSA-5654743 Signaling by FGFR4 0.075111 1.124
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.062840 1.202
R-HSA-6783589 Interleukin-6 family signaling 0.029253 1.534
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.025774 1.589
R-HSA-9022692 Regulation of MECP2 expression and activity 0.046983 1.328
R-HSA-3214847 HATs acetylate histones 0.074237 1.129
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.015088 1.821
R-HSA-111933 Calmodulin induced events 0.055843 1.253
R-HSA-111997 CaM pathway 0.055843 1.253
R-HSA-9694548 Maturation of spike protein 0.067660 1.170
R-HSA-111996 Ca-dependent events 0.072599 1.139
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.058143 1.235
R-HSA-1251985 Nuclear signaling by ERBB4 0.065235 1.186
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.077650 1.110
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.079002 1.102
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.084431 1.073
R-HSA-9660537 Signaling by MRAS-complex mutants 0.092475 1.034
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.092475 1.034
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.123953 0.907
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.131651 0.881
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.146848 0.833
R-HSA-6785631 ERBB2 Regulates Cell Motility 0.154346 0.812
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.161780 0.791
R-HSA-1963640 GRB2 events in ERBB2 signaling 0.169148 0.772
R-HSA-1963642 PI3K events in ERBB2 signaling 0.176452 0.753
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.183693 0.736
R-HSA-912631 Regulation of signaling by CBL 0.190870 0.719
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.190870 0.719
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.082809 1.082
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.082809 1.082
R-HSA-9649948 Signaling downstream of RAS mutants 0.082809 1.082
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.232636 0.633
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.232636 0.633
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.101635 0.993
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.136226 0.866
R-HSA-383280 Nuclear Receptor transcription pathway 0.176096 0.754
R-HSA-6802957 Oncogenic MAPK signaling 0.198259 0.703
R-HSA-6802949 Signaling by RAS mutants 0.082809 1.082
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.218957 0.660
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.176452 0.753
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.154346 0.812
R-HSA-399956 CRMPs in Sema3A signaling 0.146848 0.833
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.169148 0.772
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.183693 0.736
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.080216 1.096
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.154378 0.811
R-HSA-453276 Regulation of mitotic cell cycle 0.154378 0.811
R-HSA-170968 Frs2-mediated activation 0.139283 0.856
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.176452 0.753
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.197984 0.703
R-HSA-169893 Prolonged ERK activation events 0.161780 0.791
R-HSA-6807004 Negative regulation of MET activity 0.197984 0.703
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.212028 0.674
R-HSA-5673001 RAF/MAP kinase cascade 0.138938 0.857
R-HSA-170984 ARMS-mediated activation 0.100448 0.998
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.169148 0.772
R-HSA-191859 snRNP Assembly 0.118608 0.926
R-HSA-194441 Metabolism of non-coding RNA 0.118608 0.926
R-HSA-168325 Viral Messenger RNA Synthesis 0.124415 0.905
R-HSA-162599 Late Phase of HIV Life Cycle 0.168428 0.774
R-HSA-5684996 MAPK1/MAPK3 signaling 0.148362 0.829
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.232636 0.633
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.139283 0.856
R-HSA-9734767 Developmental Cell Lineages 0.240509 0.619
R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.092475 1.034
R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.131651 0.881
R-HSA-9706369 Negative regulation of FLT3 0.161780 0.791
R-HSA-379724 tRNA Aminoacylation 0.121503 0.915
R-HSA-400685 Sema4D in semaphorin signaling 0.239386 0.621
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.115731 0.937
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.196035 0.708
R-HSA-162587 HIV Life Cycle 0.201430 0.696
R-HSA-5683057 MAPK family signaling cascades 0.224280 0.649
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.082809 1.082
R-HSA-5578749 Transcriptional regulation by small RNAs 0.157448 0.803
R-HSA-438064 Post NMDA receptor activation events 0.207861 0.682
R-HSA-8953854 Metabolism of RNA 0.224495 0.649
R-HSA-5654741 Signaling by FGFR3 0.080216 1.096
R-HSA-1483249 Inositol phosphate metabolism 0.097566 1.011
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.239386 0.621
R-HSA-2980766 Nuclear Envelope Breakdown 0.112873 0.947
R-HSA-5654738 Signaling by FGFR2 0.182389 0.739
R-HSA-373755 Semaphorin interactions 0.130289 0.885
R-HSA-5654736 Signaling by FGFR1 0.110034 0.958
R-HSA-112310 Neurotransmitter release cycle 0.217512 0.663
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.225827 0.646
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.205037 0.688
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.205037 0.688
R-HSA-8878171 Transcriptional regulation by RUNX1 0.173390 0.761
R-HSA-1433559 Regulation of KIT signaling 0.146848 0.833
R-HSA-69278 Cell Cycle, Mitotic 0.148610 0.828
R-HSA-8963896 HDL assembly 0.146848 0.833
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.092475 1.034
R-HSA-391160 Signal regulatory protein family interactions 0.146848 0.833
R-HSA-9839373 Signaling by TGFBR3 0.082809 1.082
R-HSA-9671555 Signaling by PDGFR in disease 0.212028 0.674
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.130289 0.885
R-HSA-8848021 Signaling by PTK6 0.130289 0.885
R-HSA-1489509 DAG and IP3 signaling 0.080216 1.096
R-HSA-3247509 Chromatin modifying enzymes 0.187321 0.727
R-HSA-3371556 Cellular response to heat stress 0.117714 0.929
R-HSA-69620 Cell Cycle Checkpoints 0.100678 0.997
R-HSA-112043 PLC beta mediated events 0.124415 0.905
R-HSA-1169408 ISG15 antiviral mechanism 0.166726 0.778
R-HSA-4839726 Chromatin organization 0.214359 0.669
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.176452 0.753
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.176452 0.753
R-HSA-8963898 Plasma lipoprotein assembly 0.232636 0.633
R-HSA-72306 tRNA processing 0.087113 1.060
R-HSA-74160 Gene expression (Transcription) 0.221595 0.654
R-HSA-1059683 Interleukin-6 signaling 0.139283 0.856
R-HSA-112040 G-protein mediated events 0.142222 0.847
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.112873 0.947
R-HSA-1236394 Signaling by ERBB4 0.163622 0.786
R-HSA-75153 Apoptotic execution phase 0.082809 1.082
R-HSA-2028269 Signaling by Hippo 0.176452 0.753
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.088069 1.055
R-HSA-9006936 Signaling by TGFB family members 0.208209 0.681
R-HSA-8986944 Transcriptional Regulation by MECP2 0.220738 0.656
R-HSA-9694516 SARS-CoV-2 Infection 0.227477 0.643
R-HSA-9694635 Translation of Structural Proteins 0.172963 0.762
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.227202 0.644
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.246076 0.609
R-HSA-525793 Myogenesis 0.246076 0.609
R-HSA-1643713 Signaling by EGFR in Cancer 0.246076 0.609
R-HSA-190236 Signaling by FGFR 0.249916 0.602
R-HSA-445095 Interaction between L1 and Ankyrins 0.252709 0.597
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.252709 0.597
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.252709 0.597
R-HSA-70171 Glycolysis 0.256423 0.591
R-HSA-167287 HIV elongation arrest and recovery 0.259283 0.586
R-HSA-167290 Pausing and recovery of HIV elongation 0.259283 0.586
R-HSA-5576892 Phase 0 - rapid depolarisation 0.259283 0.586
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.259283 0.586
R-HSA-113418 Formation of the Early Elongation Complex 0.259283 0.586
R-HSA-1483255 PI Metabolism 0.262933 0.580
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.262933 0.580
R-HSA-112316 Neuronal System 0.263559 0.579
R-HSA-201681 TCF dependent signaling in response to WNT 0.263998 0.578
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.265800 0.575
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.269444 0.570
R-HSA-111885 Opioid Signalling 0.269444 0.570
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.272260 0.565
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.272260 0.565
R-HSA-8863795 Downregulation of ERBB2 signaling 0.272260 0.565
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.272260 0.565
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.272260 0.565
R-HSA-182971 EGFR downregulation 0.278664 0.555
R-HSA-399719 Trafficking of AMPA receptors 0.278664 0.555
R-HSA-211000 Gene Silencing by RNA 0.282462 0.549
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.282462 0.549
R-HSA-9700206 Signaling by ALK in cancer 0.282462 0.549
R-HSA-9675126 Diseases of mitotic cell cycle 0.285012 0.545
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.285012 0.545
R-HSA-72163 mRNA Splicing - Major Pathway 0.290197 0.537
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.291304 0.536
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.291304 0.536
R-HSA-202403 TCR signaling 0.292214 0.534
R-HSA-390522 Striated Muscle Contraction 0.297541 0.526
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.297541 0.526
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.303724 0.518
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.309852 0.509
R-HSA-187687 Signalling to ERKs 0.309852 0.509
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.309852 0.509
R-HSA-1640170 Cell Cycle 0.314841 0.502
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.315927 0.500
R-HSA-74158 RNA Polymerase III Transcription 0.315927 0.500
R-HSA-9682385 FLT3 signaling in disease 0.315927 0.500
R-HSA-72172 mRNA Splicing 0.316583 0.500
R-HSA-373760 L1CAM interactions 0.318124 0.497
R-HSA-70326 Glucose metabolism 0.321349 0.493
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.321949 0.492
R-HSA-68875 Mitotic Prophase 0.331002 0.480
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.333836 0.476
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.333836 0.476
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.335812 0.474
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.339701 0.469
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.339701 0.469
R-HSA-167169 HIV Transcription Elongation 0.339701 0.469
R-HSA-73857 RNA Polymerase II Transcription 0.342743 0.465
R-HSA-162909 Host Interactions of HIV factors 0.343813 0.464
R-HSA-3214841 PKMTs methylate histone lysines 0.345515 0.462
R-HSA-8853884 Transcriptional Regulation by VENTX 0.345515 0.462
R-HSA-9607240 FLT3 Signaling 0.345515 0.462
R-HSA-5674135 MAP2K and MAPK activation 0.351279 0.454
R-HSA-5675221 Negative regulation of MAPK pathway 0.351279 0.454
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.356992 0.447
R-HSA-162582 Signal Transduction 0.357597 0.447
R-HSA-112315 Transmission across Chemical Synapses 0.358343 0.446
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.359717 0.444
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.362655 0.441
R-HSA-1433557 Signaling by SCF-KIT 0.362655 0.441
R-HSA-2172127 DAP12 interactions 0.368268 0.434
R-HSA-375280 Amine ligand-binding receptors 0.368268 0.434
R-HSA-162906 HIV Infection 0.371775 0.430
R-HSA-9705683 SARS-CoV-2-host interactions 0.374163 0.427
R-HSA-8856688 Golgi-to-ER retrograde transport 0.375480 0.425
R-HSA-199991 Membrane Trafficking 0.377172 0.423
R-HSA-72165 mRNA Splicing - Minor Pathway 0.379348 0.421
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.379348 0.421
R-HSA-437239 Recycling pathway of L1 0.384815 0.415
R-HSA-1483191 Synthesis of PC 0.384815 0.415
R-HSA-9031628 NGF-stimulated transcription 0.390235 0.409
R-HSA-9018519 Estrogen-dependent gene expression 0.391084 0.408
R-HSA-157858 Gap junction trafficking and regulation 0.395607 0.403
R-HSA-5658442 Regulation of RAS by GAPs 0.400932 0.397
R-HSA-3371571 HSF1-dependent transactivation 0.406211 0.391
R-HSA-112382 Formation of RNA Pol II elongation complex 0.411443 0.386
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.412636 0.384
R-HSA-8856828 Clathrin-mediated endocytosis 0.415685 0.381
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.416630 0.380
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.416630 0.380
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.421771 0.375
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.426867 0.370
R-HSA-166520 Signaling by NTRKs 0.430809 0.366
R-HSA-177929 Signaling by EGFR 0.431919 0.365
R-HSA-193648 NRAGE signals death through JNK 0.431919 0.365
R-HSA-5578775 Ion homeostasis 0.431919 0.365
R-HSA-429914 Deadenylation-dependent mRNA decay 0.446810 0.350
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.448683 0.348
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.451632 0.345
R-HSA-1989781 PPARA activates gene expression 0.451632 0.345
R-HSA-1227986 Signaling by ERBB2 0.451687 0.345
R-HSA-983189 Kinesins 0.451687 0.345
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.451687 0.345
R-HSA-9610379 HCMV Late Events 0.457503 0.340
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.457503 0.340
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.461314 0.336
R-HSA-9707616 Heme signaling 0.461314 0.336
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.461314 0.336
R-HSA-936837 Ion transport by P-type ATPases 0.470772 0.327
R-HSA-109581 Apoptosis 0.472022 0.326
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.480066 0.319
R-HSA-5619102 SLC transporter disorders 0.486308 0.313
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.488584 0.311
R-HSA-167172 Transcription of the HIV genome 0.489197 0.311
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.489197 0.311
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.489197 0.311
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.498170 0.303
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.502597 0.299
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.502597 0.299
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.505903 0.296
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.505903 0.296
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.506986 0.295
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.506986 0.295
R-HSA-69052 Switching of origins to a post-replicative state 0.511336 0.291
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.511336 0.291
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.511413 0.291
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.515648 0.288
R-HSA-168255 Influenza Infection 0.522313 0.282
R-HSA-212436 Generic Transcription Pathway 0.526641 0.278
R-HSA-1483257 Phospholipid metabolism 0.527068 0.278
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.532521 0.274
R-HSA-416482 G alpha (12/13) signalling events 0.532521 0.274
R-HSA-195721 Signaling by WNT 0.533457 0.273
R-HSA-6806834 Signaling by MET 0.540737 0.267
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.548810 0.261
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.556742 0.254
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.564536 0.248
R-HSA-9609690 HCMV Early Events 0.566805 0.247
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.566805 0.247
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.568381 0.245
R-HSA-1500931 Cell-Cell communication 0.570757 0.244
R-HSA-9679506 SARS-CoV Infections 0.576709 0.239
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.576835 0.239
R-HSA-5357801 Programmed Cell Death 0.591563 0.228
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.594373 0.226
R-HSA-68867 Assembly of the pre-replicative complex 0.597957 0.223
R-HSA-5653656 Vesicle-mediated transport 0.600358 0.222
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.601509 0.221
R-HSA-397014 Muscle contraction 0.608264 0.216
R-HSA-6807878 COPI-mediated anterograde transport 0.611980 0.213
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.611980 0.213
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.615410 0.211
R-HSA-9006925 Intracellular signaling by second messengers 0.621304 0.207
R-HSA-418990 Adherens junctions interactions 0.622165 0.206
R-HSA-193704 p75 NTR receptor-mediated signalling 0.622179 0.206
R-HSA-3700989 Transcriptional Regulation by TP53 0.623824 0.205
R-HSA-69239 Synthesis of DNA 0.651203 0.186
R-HSA-69002 DNA Replication Pre-Initiation 0.657346 0.182
R-HSA-8939211 ESR-mediated signaling 0.663690 0.178
R-HSA-5619115 Disorders of transmembrane transporters 0.684043 0.165
R-HSA-9007101 Rab regulation of trafficking 0.686487 0.163
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.689262 0.162
R-HSA-9609646 HCMV Infection 0.689950 0.161
R-HSA-421270 Cell-cell junction organization 0.691900 0.160
R-HSA-913531 Interferon Signaling 0.694142 0.159
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.702775 0.153
R-HSA-2132295 MHC class II antigen presentation 0.702775 0.153
R-HSA-114608 Platelet degranulation 0.715705 0.145
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.723193 0.141
R-HSA-5576891 Cardiac conduction 0.728076 0.138
R-HSA-9909396 Circadian clock 0.730485 0.136
R-HSA-418594 G alpha (i) signalling events 0.730813 0.136
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.732874 0.135
R-HSA-422475 Axon guidance 0.738738 0.132
R-HSA-446728 Cell junction organization 0.740825 0.130
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.747485 0.126
R-HSA-199977 ER to Golgi Anterograde Transport 0.768347 0.114
R-HSA-69242 S Phase 0.770402 0.113
R-HSA-69306 DNA Replication 0.780407 0.108
R-HSA-9675108 Nervous system development 0.782156 0.107
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.782356 0.107
R-HSA-73887 Death Receptor Signaling 0.782356 0.107
R-HSA-877300 Interferon gamma signaling 0.791844 0.101
R-HSA-5633007 Regulation of TP53 Activity 0.793692 0.100
R-HSA-6798695 Neutrophil degranulation 0.796116 0.099
R-HSA-2408522 Selenoamino acid metabolism 0.800922 0.096
R-HSA-212165 Epigenetic regulation of gene expression 0.807694 0.093
R-HSA-2559583 Cellular Senescence 0.828944 0.081
R-HSA-69275 G2/M Transition 0.837868 0.077
R-HSA-453274 Mitotic G2-G2/M phases 0.840739 0.075
R-HSA-983712 Ion channel transport 0.842155 0.075
R-HSA-9006931 Signaling by Nuclear Receptors 0.853850 0.069
R-HSA-948021 Transport to the Golgi and subsequent modification 0.859469 0.066
R-HSA-1483206 Glycerophospholipid biosynthesis 0.860720 0.065
R-HSA-9730414 MITF-M-regulated melanocyte development 0.873771 0.059
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.873844 0.059
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.890616 0.050
R-HSA-2262752 Cellular responses to stress 0.901494 0.045
R-HSA-72766 Translation 0.909186 0.041
R-HSA-1280218 Adaptive Immune System 0.914429 0.039
R-HSA-388396 GPCR downstream signalling 0.923937 0.034
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.924852 0.034
R-HSA-76002 Platelet activation, signaling and aggregation 0.926943 0.033
R-HSA-1257604 PIP3 activates AKT signaling 0.939510 0.027
R-HSA-9824446 Viral Infection Pathways 0.943948 0.025
R-HSA-8953897 Cellular responses to stimuli 0.949133 0.023
R-HSA-372790 Signaling by GPCR 0.953952 0.020
R-HSA-1280215 Cytokine Signaling in Immune system 0.967939 0.014
R-HSA-9824439 Bacterial Infection Pathways 0.974558 0.011
R-HSA-109582 Hemostasis 0.975113 0.011
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.975462 0.011
R-HSA-449147 Signaling by Interleukins 0.979297 0.009
R-HSA-446203 Asparagine N-linked glycosylation 0.980960 0.008
R-HSA-1266738 Developmental Biology 0.992859 0.003
R-HSA-5663205 Infectious disease 0.994867 0.002
R-HSA-500792 GPCR ligand binding 0.995846 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.996816 0.001
R-HSA-1643685 Disease 0.996904 0.001
R-HSA-556833 Metabolism of lipids 0.997867 0.001
R-HSA-168256 Immune System 0.998072 0.001
R-HSA-382551 Transport of small molecules 0.998862 0.000
R-HSA-597592 Post-translational protein modification 0.999378 0.000
R-HSA-168249 Innate Immune System 0.999610 0.000
R-HSA-392499 Metabolism of proteins 0.999966 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.862 0.793 1 0.918
CDK18CDK18 0.853 0.804 1 0.924
DYRK2DYRK2 0.852 0.775 1 0.874
CDK19CDK19 0.851 0.797 1 0.914
JNK2JNK2 0.850 0.828 1 0.928
DYRK4DYRK4 0.850 0.770 1 0.928
HIPK4HIPK4 0.849 0.617 1 0.721
KISKIS 0.848 0.707 1 0.885
CDK3CDK3 0.848 0.726 1 0.933
P38DP38D 0.848 0.826 1 0.941
CLK3CLK3 0.847 0.574 1 0.698
CDK7CDK7 0.847 0.777 1 0.908
CDK1CDK1 0.846 0.777 1 0.920
P38GP38G 0.846 0.812 1 0.938
CDK17CDK17 0.845 0.796 1 0.932
CDK8CDK8 0.845 0.785 1 0.897
P38BP38B 0.844 0.821 1 0.902
ERK1ERK1 0.839 0.791 1 0.914
HIPK1HIPK1 0.839 0.719 1 0.859
JNK3JNK3 0.837 0.801 1 0.915
CDK16CDK16 0.836 0.763 1 0.927
DYRK1BDYRK1B 0.836 0.727 1 0.901
CLK2CLK2 0.834 0.483 -3 0.858
DYRK1ADYRK1A 0.834 0.676 1 0.847
CDK5CDK5 0.833 0.734 1 0.892
SRPK1SRPK1 0.833 0.413 -3 0.847
P38AP38A 0.832 0.788 1 0.869
CDK14CDK14 0.832 0.764 1 0.905
CDK13CDK13 0.832 0.734 1 0.918
CDK10CDK10 0.831 0.714 1 0.914
CDK12CDK12 0.830 0.740 1 0.927
MAKMAK 0.827 0.629 -2 0.878
CDK9CDK9 0.825 0.720 1 0.915
HIPK3HIPK3 0.824 0.685 1 0.834
NLKNLK 0.822 0.669 1 0.729
ICKICK 0.822 0.507 -3 0.907
JNK1JNK1 0.821 0.722 1 0.924
CLK1CLK1 0.821 0.458 -3 0.854
ERK2ERK2 0.819 0.745 1 0.889
CLK4CLK4 0.819 0.426 -3 0.870
DYRK3DYRK3 0.819 0.570 1 0.829
SRPK2SRPK2 0.816 0.330 -3 0.787
CDKL5CDKL5 0.815 0.307 -3 0.877
ERK5ERK5 0.814 0.397 1 0.645
CDK4CDK4 0.811 0.726 1 0.928
CDK2CDK2 0.811 0.575 1 0.840
NDR2NDR2 0.811 0.133 -3 0.914
PRKD1PRKD1 0.809 0.151 -3 0.906
CDKL1CDKL1 0.809 0.272 -3 0.878
CDK6CDK6 0.808 0.696 1 0.913
MOKMOK 0.808 0.560 1 0.772
MTORMTOR 0.807 0.214 1 0.539
COTCOT 0.807 -0.014 2 0.834
PIM3PIM3 0.806 0.108 -3 0.911
RSK2RSK2 0.805 0.130 -3 0.874
SRPK3SRPK3 0.803 0.285 -3 0.814
PRKD2PRKD2 0.802 0.127 -3 0.884
CDC7CDC7 0.802 -0.009 1 0.423
MOSMOS 0.801 0.065 1 0.457
P90RSKP90RSK 0.800 0.133 -3 0.870
SKMLCKSKMLCK 0.799 0.076 -2 0.818
PIM1PIM1 0.797 0.135 -3 0.885
CAMK1BCAMK1B 0.795 0.060 -3 0.916
NDR1NDR1 0.795 0.050 -3 0.911
AURCAURC 0.794 0.067 -2 0.618
PRP4PRP4 0.794 0.435 -3 0.766
MAPKAPK2MAPKAPK2 0.794 0.089 -3 0.844
GRK1GRK1 0.794 0.052 -2 0.745
PRPKPRPK 0.794 -0.045 -1 0.780
LATS2LATS2 0.793 0.060 -5 0.754
ATRATR 0.793 0.018 1 0.446
RSK3RSK3 0.793 0.079 -3 0.862
CHAK2CHAK2 0.792 0.027 -1 0.781
RSK4RSK4 0.792 0.127 -3 0.854
TBK1TBK1 0.790 -0.094 1 0.345
NUAK2NUAK2 0.789 0.071 -3 0.925
MAPKAPK3MAPKAPK3 0.789 0.049 -3 0.878
IKKBIKKB 0.788 -0.127 -2 0.677
WNK1WNK1 0.788 -0.029 -2 0.846
PKN3PKN3 0.788 0.021 -3 0.902
PKACGPKACG 0.788 0.038 -2 0.689
PKACBPKACB 0.788 0.094 -2 0.623
CAMK2DCAMK2D 0.788 0.009 -3 0.906
AMPKA1AMPKA1 0.787 0.021 -3 0.929
CAMLCKCAMLCK 0.787 0.043 -2 0.789
LATS1LATS1 0.786 0.137 -3 0.912
GSK3AGSK3A 0.786 0.262 4 0.569
PRKXPRKX 0.785 0.118 -3 0.816
RAF1RAF1 0.785 -0.162 1 0.405
MARK4MARK4 0.785 -0.014 4 0.811
PDHK4PDHK4 0.785 -0.158 1 0.457
IKKEIKKE 0.785 -0.130 1 0.346
AMPKA2AMPKA2 0.785 0.047 -3 0.912
CAMK2ACAMK2A 0.785 0.076 2 0.767
P70S6KBP70S6KB 0.785 0.056 -3 0.886
NIKNIK 0.784 -0.006 -3 0.914
DAPK2DAPK2 0.784 0.032 -3 0.917
IKKAIKKA 0.783 -0.051 -2 0.673
CAMK2GCAMK2G 0.783 -0.087 2 0.778
TSSK1TSSK1 0.783 0.044 -3 0.944
MST4MST4 0.783 -0.033 2 0.785
RIPK3RIPK3 0.781 -0.098 3 0.681
PKCDPKCD 0.781 0.014 2 0.711
PRKD3PRKD3 0.781 0.078 -3 0.851
PAK1PAK1 0.781 0.009 -2 0.748
BMPR2BMPR2 0.781 -0.210 -2 0.807
PKN2PKN2 0.781 -0.023 -3 0.907
AKT2AKT2 0.780 0.110 -3 0.813
MSK1MSK1 0.780 0.064 -3 0.847
CAMK2BCAMK2B 0.780 0.021 2 0.770
GRK7GRK7 0.779 0.038 1 0.414
HUNKHUNK 0.779 -0.120 2 0.807
PKG2PKG2 0.779 0.049 -2 0.634
GRK5GRK5 0.778 -0.116 -3 0.844
MNK1MNK1 0.778 0.043 -2 0.743
MNK2MNK2 0.778 -0.004 -2 0.737
GCN2GCN2 0.778 -0.235 2 0.755
TSSK2TSSK2 0.778 -0.018 -5 0.803
PAK6PAK6 0.777 0.034 -2 0.656
MASTLMASTL 0.777 -0.108 -2 0.760
MSK2MSK2 0.777 0.032 -3 0.842
QSKQSK 0.777 0.026 4 0.784
TGFBR2TGFBR2 0.776 -0.098 -2 0.707
PAK3PAK3 0.776 -0.027 -2 0.734
PDHK1PDHK1 0.776 -0.199 1 0.429
ULK2ULK2 0.776 -0.232 2 0.742
NIM1NIM1 0.775 -0.064 3 0.713
DNAPKDNAPK 0.775 -0.010 1 0.409
AURBAURB 0.774 0.014 -2 0.607
BMPR1BBMPR1B 0.774 -0.028 1 0.388
MLK2MLK2 0.774 -0.073 2 0.772
PASKPASK 0.774 0.125 -3 0.915
PKCBPKCB 0.774 -0.001 2 0.648
SGK3SGK3 0.773 0.056 -3 0.870
BRSK1BRSK1 0.773 0.011 -3 0.886
NUAK1NUAK1 0.773 0.026 -3 0.885
PIM2PIM2 0.773 0.099 -3 0.854
DSTYKDSTYK 0.773 -0.211 2 0.836
MPSK1MPSK1 0.773 0.147 1 0.431
ERK7ERK7 0.773 0.207 2 0.425
MELKMELK 0.772 -0.010 -3 0.898
GRK6GRK6 0.772 -0.109 1 0.403
NEK6NEK6 0.771 -0.147 -2 0.765
DCAMKL1DCAMKL1 0.771 0.047 -3 0.893
SIKSIK 0.771 0.017 -3 0.860
MLK1MLK1 0.770 -0.172 2 0.740
CAMK4CAMK4 0.770 -0.064 -3 0.903
WNK3WNK3 0.770 -0.206 1 0.392
BCKDKBCKDK 0.770 -0.170 -1 0.676
TGFBR1TGFBR1 0.770 -0.055 -2 0.728
BRSK2BRSK2 0.770 -0.027 -3 0.900
GSK3BGSK3B 0.769 0.117 4 0.563
MLK3MLK3 0.769 -0.056 2 0.660
PKACAPKACA 0.769 0.070 -2 0.582
DLKDLK 0.769 -0.169 1 0.405
PKCGPKCG 0.769 -0.020 2 0.650
PKCAPKCA 0.769 -0.009 2 0.642
MYLK4MYLK4 0.769 0.008 -2 0.711
PHKG1PHKG1 0.769 -0.032 -3 0.909
RIPK1RIPK1 0.768 -0.183 1 0.386
SMG1SMG1 0.768 -0.057 1 0.419
IRE1IRE1 0.768 -0.102 1 0.383
MARK3MARK3 0.768 -0.005 4 0.739
ULK1ULK1 0.768 -0.213 -3 0.790
PKCZPKCZ 0.768 -0.027 2 0.705
ATMATM 0.768 -0.080 1 0.410
ALK4ALK4 0.768 -0.071 -2 0.757
CHK1CHK1 0.767 0.017 -3 0.895
VRK2VRK2 0.767 0.033 1 0.488
QIKQIK 0.766 -0.075 -3 0.898
PAK2PAK2 0.766 -0.046 -2 0.726
NEK7NEK7 0.765 -0.265 -3 0.823
FAM20CFAM20C 0.765 -0.018 2 0.615
GRK4GRK4 0.763 -0.170 -2 0.750
PKRPKR 0.763 -0.101 1 0.414
CAMK1GCAMK1G 0.763 0.004 -3 0.861
AURAAURA 0.762 -0.016 -2 0.573
MARK2MARK2 0.762 -0.031 4 0.709
NEK9NEK9 0.762 -0.237 2 0.777
AKT1AKT1 0.762 0.062 -3 0.834
CHAK1CHAK1 0.762 -0.121 2 0.738
PKCHPKCH 0.761 -0.051 2 0.637
MAPKAPK5MAPKAPK5 0.760 -0.031 -3 0.821
TTBK2TTBK2 0.760 -0.194 2 0.668
IRE2IRE2 0.760 -0.090 2 0.675
TLK2TLK2 0.760 -0.122 1 0.388
YSK4YSK4 0.760 -0.163 1 0.368
SBKSBK 0.760 0.192 -3 0.715
MEK1MEK1 0.759 -0.165 2 0.815
DCAMKL2DCAMKL2 0.759 0.001 -3 0.901
SSTKSSTK 0.758 -0.011 4 0.775
PAK4PAK4 0.758 0.010 -2 0.607
PAK5PAK5 0.758 -0.004 -2 0.601
ANKRD3ANKRD3 0.758 -0.257 1 0.417
CK1ECK1E 0.758 0.002 -3 0.563
SGK1SGK1 0.757 0.108 -3 0.745
ACVR2BACVR2B 0.757 -0.110 -2 0.710
P70S6KP70S6K 0.757 0.027 -3 0.817
AKT3AKT3 0.757 0.088 -3 0.763
MST3MST3 0.756 -0.051 2 0.772
CAMK1DCAMK1D 0.756 0.042 -3 0.815
MARK1MARK1 0.756 -0.053 4 0.753
ALK2ALK2 0.756 -0.095 -2 0.727
PLK1PLK1 0.756 -0.185 -2 0.698
ACVR2AACVR2A 0.755 -0.118 -2 0.700
GRK2GRK2 0.755 -0.083 -2 0.647
DRAK1DRAK1 0.755 -0.126 1 0.371
WNK4WNK4 0.753 -0.112 -2 0.839
NEK2NEK2 0.753 -0.198 2 0.740
SMMLCKSMMLCK 0.753 -0.006 -3 0.891
PKCTPKCT 0.752 -0.044 2 0.650
MLK4MLK4 0.752 -0.144 2 0.649
PKCEPKCE 0.752 0.020 2 0.635
TAO3TAO3 0.752 -0.048 1 0.412
PINK1PINK1 0.752 0.042 1 0.572
BUB1BUB1 0.751 0.075 -5 0.768
GAKGAK 0.751 -0.004 1 0.443
PLK3PLK3 0.751 -0.151 2 0.753
SNRKSNRK 0.751 -0.152 2 0.636
PLK4PLK4 0.751 -0.160 2 0.611
BMPR1ABMPR1A 0.751 -0.071 1 0.372
CK1DCK1D 0.750 0.015 -3 0.513
LKB1LKB1 0.750 -0.043 -3 0.850
MEK5MEK5 0.750 -0.189 2 0.783
PKCIPKCI 0.750 -0.040 2 0.657
DAPK3DAPK3 0.750 0.017 -3 0.893
PHKG2PHKG2 0.749 -0.058 -3 0.889
ROCK2ROCK2 0.748 0.061 -3 0.887
IRAK4IRAK4 0.748 -0.138 1 0.370
MRCKAMRCKA 0.748 0.050 -3 0.859
PDK1PDK1 0.747 -0.034 1 0.420
MRCKBMRCKB 0.747 0.048 -3 0.847
NEK5NEK5 0.746 -0.186 1 0.393
DAPK1DAPK1 0.746 0.013 -3 0.879
PBKPBK 0.745 0.005 1 0.400
CK1A2CK1A2 0.745 -0.011 -3 0.519
GCKGCK 0.745 -0.053 1 0.403
CK2A2CK2A2 0.745 -0.057 1 0.334
DMPK1DMPK1 0.745 0.099 -3 0.869
MEKK2MEKK2 0.745 -0.172 2 0.757
BRAFBRAF 0.745 -0.188 -4 0.734
PKN1PKN1 0.745 0.005 -3 0.840
NEK11NEK11 0.744 -0.150 1 0.404
CHK2CHK2 0.744 0.048 -3 0.772
PERKPERK 0.744 -0.214 -2 0.751
MEKK3MEKK3 0.744 -0.220 1 0.393
CK1G1CK1G1 0.743 -0.048 -3 0.534
ZAKZAK 0.743 -0.213 1 0.370
CAMK1ACAMK1A 0.742 0.041 -3 0.779
MEKK1MEKK1 0.742 -0.217 1 0.390
MEKK6MEKK6 0.741 -0.099 1 0.393
MAP3K15MAP3K15 0.741 -0.081 1 0.379
GRK3GRK3 0.741 -0.082 -2 0.604
TAO2TAO2 0.741 -0.097 2 0.778
HPK1HPK1 0.740 -0.073 1 0.400
TLK1TLK1 0.740 -0.202 -2 0.738
KHS1KHS1 0.740 -0.022 1 0.388
CRIKCRIK 0.739 0.083 -3 0.831
CAMKK2CAMKK2 0.739 -0.157 -2 0.696
TNIKTNIK 0.739 -0.055 3 0.830
HRIHRI 0.739 -0.253 -2 0.763
CK2A1CK2A1 0.738 -0.056 1 0.322
HASPINHASPIN 0.738 0.027 -1 0.651
LOKLOK 0.738 -0.073 -2 0.710
HGKHGK 0.738 -0.093 3 0.812
LRRK2LRRK2 0.737 -0.053 2 0.779
PKG1PKG1 0.737 0.007 -2 0.557
KHS2KHS2 0.737 -0.023 1 0.404
SLKSLK 0.735 -0.069 -2 0.667
CAMKK1CAMKK1 0.734 -0.243 -2 0.685
EEF2KEEF2K 0.734 -0.094 3 0.782
MINKMINK 0.734 -0.141 1 0.375
NEK8NEK8 0.732 -0.237 2 0.747
PDHK3_TYRPDHK3_TYR 0.732 0.251 4 0.884
NEK4NEK4 0.732 -0.206 1 0.371
TTBK1TTBK1 0.731 -0.198 2 0.590
ROCK1ROCK1 0.730 0.026 -3 0.860
TAK1TAK1 0.730 -0.204 1 0.394
VRK1VRK1 0.730 -0.164 2 0.803
MST2MST2 0.729 -0.190 1 0.388
NEK1NEK1 0.729 -0.185 1 0.370
STK33STK33 0.729 -0.146 2 0.591
IRAK1IRAK1 0.728 -0.275 -1 0.662
PLK2PLK2 0.727 -0.094 -3 0.720
LIMK2_TYRLIMK2_TYR 0.724 0.185 -3 0.909
MST1MST1 0.723 -0.177 1 0.372
YSK1YSK1 0.722 -0.157 2 0.737
TESK1_TYRTESK1_TYR 0.721 0.086 3 0.826
PDHK4_TYRPDHK4_TYR 0.721 0.101 2 0.853
YANK3YANK3 0.719 -0.044 2 0.397
BIKEBIKE 0.719 -0.041 1 0.394
PKMYT1_TYRPKMYT1_TYR 0.717 0.114 3 0.791
MAP2K4_TYRMAP2K4_TYR 0.717 0.044 -1 0.779
AAK1AAK1 0.717 0.017 1 0.368
MAP2K6_TYRMAP2K6_TYR 0.716 0.044 -1 0.785
MEK2MEK2 0.716 -0.263 2 0.781
ASK1ASK1 0.716 -0.128 1 0.372
OSR1OSR1 0.715 -0.125 2 0.755
NEK3NEK3 0.715 -0.180 1 0.374
RIPK2RIPK2 0.714 -0.273 1 0.343
MAP2K7_TYRMAP2K7_TYR 0.713 -0.068 2 0.826
PDHK1_TYRPDHK1_TYR 0.711 -0.019 -1 0.795
MYO3BMYO3B 0.711 -0.115 2 0.747
CK1ACK1A 0.711 -0.032 -3 0.419
TAO1TAO1 0.711 -0.118 1 0.360
BMPR2_TYRBMPR2_TYR 0.711 -0.009 -1 0.778
ALPHAK3ALPHAK3 0.710 -0.103 -1 0.679
TTKTTK 0.709 -0.141 -2 0.726
PINK1_TYRPINK1_TYR 0.706 -0.145 1 0.444
MYO3AMYO3A 0.706 -0.140 1 0.384
LIMK1_TYRLIMK1_TYR 0.704 -0.029 2 0.803
EPHA6EPHA6 0.703 -0.082 -1 0.760
RETRET 0.703 -0.131 1 0.407
MST1RMST1R 0.699 -0.121 3 0.740
DDR1DDR1 0.699 -0.107 4 0.802
EPHB4EPHB4 0.699 -0.112 -1 0.728
JAK2JAK2 0.698 -0.127 1 0.411
TNK2TNK2 0.698 -0.067 3 0.690
NEK10_TYRNEK10_TYR 0.697 -0.087 1 0.362
CSF1RCSF1R 0.697 -0.097 3 0.719
ROS1ROS1 0.696 -0.124 3 0.682
TXKTXK 0.696 -0.067 1 0.378
ABL2ABL2 0.696 -0.098 -1 0.702
TYK2TYK2 0.695 -0.221 1 0.395
YES1YES1 0.695 -0.095 -1 0.787
TYRO3TYRO3 0.695 -0.174 3 0.718
TNK1TNK1 0.694 -0.045 3 0.705
ABL1ABL1 0.693 -0.103 -1 0.695
FGRFGR 0.693 -0.126 1 0.386
JAK3JAK3 0.693 -0.145 1 0.396
EPHA4EPHA4 0.692 -0.089 2 0.762
STLK3STLK3 0.692 -0.235 1 0.348
FGFR2FGFR2 0.691 -0.083 3 0.712
LCKLCK 0.690 -0.091 -1 0.769
JAK1JAK1 0.690 -0.091 1 0.370
DDR2DDR2 0.689 -0.000 3 0.641
TNNI3K_TYRTNNI3K_TYR 0.689 -0.064 1 0.399
HCKHCK 0.688 -0.153 -1 0.760
BLKBLK 0.688 -0.082 -1 0.769
TEKTEK 0.687 -0.067 3 0.645
INSRRINSRR 0.687 -0.161 3 0.654
SRMSSRMS 0.687 -0.178 1 0.384
KDRKDR 0.686 -0.115 3 0.684
FGFR1FGFR1 0.686 -0.093 3 0.673
ITKITK 0.686 -0.151 -1 0.712
KITKIT 0.685 -0.151 3 0.720
FERFER 0.685 -0.215 1 0.407
EPHB1EPHB1 0.684 -0.188 1 0.384
MERTKMERTK 0.684 -0.157 3 0.699
FYNFYN 0.684 -0.074 -1 0.772
EPHB3EPHB3 0.683 -0.170 -1 0.712
YANK2YANK2 0.683 -0.074 2 0.410
AXLAXL 0.683 -0.175 3 0.695
METMET 0.682 -0.127 3 0.715
EPHB2EPHB2 0.681 -0.171 -1 0.702
BMXBMX 0.681 -0.128 -1 0.648
FGFR3FGFR3 0.680 -0.104 3 0.686
FLT3FLT3 0.680 -0.215 3 0.716
CK1G3CK1G3 0.679 -0.063 -3 0.370
WEE1_TYRWEE1_TYR 0.679 -0.125 -1 0.657
EPHA7EPHA7 0.678 -0.140 2 0.750
PDGFRBPDGFRB 0.678 -0.257 3 0.723
PTK2BPTK2B 0.676 -0.111 -1 0.690
TECTEC 0.676 -0.177 -1 0.653
EPHA1EPHA1 0.675 -0.165 3 0.686
EPHA3EPHA3 0.675 -0.166 2 0.732
PDGFRAPDGFRA 0.675 -0.239 3 0.722
FRKFRK 0.675 -0.167 -1 0.748
ERBB2ERBB2 0.675 -0.194 1 0.372
FLT1FLT1 0.674 -0.169 -1 0.715
BTKBTK 0.674 -0.246 -1 0.678
PTK2PTK2 0.673 -0.053 -1 0.717
ALKALK 0.672 -0.199 3 0.612
LTKLTK 0.672 -0.200 3 0.647
SRCSRC 0.671 -0.128 -1 0.756
LYNLYN 0.671 -0.162 3 0.635
PTK6PTK6 0.670 -0.243 -1 0.640
INSRINSR 0.670 -0.191 3 0.640
EGFREGFR 0.670 -0.133 1 0.321
NTRK1NTRK1 0.670 -0.254 -1 0.705
EPHA8EPHA8 0.669 -0.134 -1 0.707
NTRK3NTRK3 0.669 -0.175 -1 0.666
EPHA5EPHA5 0.669 -0.163 2 0.749
SYKSYK 0.668 -0.084 -1 0.693
FLT4FLT4 0.668 -0.209 3 0.673
FGFR4FGFR4 0.667 -0.131 -1 0.654
CK1G2CK1G2 0.666 -0.058 -3 0.459
CSKCSK 0.666 -0.162 2 0.756
MATKMATK 0.665 -0.148 -1 0.624
NTRK2NTRK2 0.664 -0.268 3 0.669
ERBB4ERBB4 0.662 -0.103 1 0.330
EPHA2EPHA2 0.659 -0.150 -1 0.661
ZAP70ZAP70 0.656 -0.063 -1 0.625
MUSKMUSK 0.655 -0.187 1 0.313
IGF1RIGF1R 0.654 -0.185 3 0.574
FESFES 0.644 -0.181 -1 0.622