Motif 225 (n=139)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0MZ66 | SHTN1 | S502 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
A1A5D9 | BICDL2 | S331 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
E9PAV3 | NACA | S1581 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
K7ELQ4 | ATF7-NPFF | S174 | ochoa | ATF7-NPFF readthrough | None |
O00139 | KIF2A | S75 | ochoa | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
O00429 | DNM1L | S616 | ochoa|psp | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
O00512 | BCL9 | S19 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
O00512 | BCL9 | S294 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
O00512 | BCL9 | S873 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
O14994 | SYN3 | S470 | ochoa|psp | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
O15075 | DCLK1 | S332 | ochoa | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. |
O15117 | FYB1 | S209 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
O15389 | SIGLEC5 | S488 | ochoa | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
O43314 | PPIP5K2 | S1180 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
O43379 | WDR62 | S33 | ochoa|psp | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
O43491 | EPB41L2 | S562 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
O75152 | ZC3H11A | S116 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
O75312 | ZPR1 | S19 | ochoa | Zinc finger protein ZPR1 (Zinc finger protein 259) | Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (PubMed:29851065). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. {ECO:0000269|PubMed:11283611, ECO:0000269|PubMed:17068332, ECO:0000269|PubMed:22422766, ECO:0000269|PubMed:29851065}. |
O75533 | SF3B1 | S336 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
O95359 | TACC2 | S2557 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
P04626 | ERBB2 | S1235 | ochoa | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
P06401 | PGR | S20 | ochoa | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
P07197 | NEFM | S628 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
P07197 | NEFM | S667 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
P07197 | NEFM | S680 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
P09543 | CNP | S318 | ochoa | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) | Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates (By similarity). May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). {ECO:0000250|UniProtKB:P06623, ECO:0000250|UniProtKB:P16330}. |
P15056 | BRAF | S335 | psp | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:36402789, ECO:0000305}. |
P21917 | DRD4 | S245 | psp | D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) | Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:9003072). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:16423344, PubMed:27659709, PubMed:29051383, PubMed:7512953, PubMed:7643093). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250|UniProtKB:P51436, ECO:0000269|PubMed:16423344, ECO:0000269|PubMed:1840645, ECO:0000269|PubMed:27659709, ECO:0000269|PubMed:29051383, ECO:0000269|PubMed:7512953, ECO:0000269|PubMed:7643093, ECO:0000269|PubMed:8078498, ECO:0000269|PubMed:9003072}. |
P22681 | CBL | S483 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
P43403 | ZAP70 | S301 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
P49585 | PCYT1A | S331 | ochoa | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
P53805 | RCAN1 | S163 | ochoa|psp | Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q9JHG6, ECO:0000269|PubMed:12809556}. |
P54577 | YARS1 | S338 | ochoa | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949). {ECO:0000269|PubMed:25533949, ECO:0000305|PubMed:16429158, ECO:0000305|PubMed:9162081}. |
P54845 | NRL | S50 | psp | Neural retina-specific leucine zipper protein (NRL) | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds to the rhodopsin promoter in a sequence-specific manner (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}. |
P55198 | MLLT6 | S382 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
P57682 | KLF3 | S92 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
P78524 | DENND2B | S413 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
P78559 | MAP1A | S2617 | ochoa|psp | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
Q02410 | APBA1 | S313 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
Q07157 | TJP1 | S1051 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q12955 | ANK3 | S4333 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
Q13938 | CAPS | S40 | ochoa | Calcyphosin (Calcyphosine) | Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}. |
Q14135 | VGLL4 | S139 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
Q14194 | CRMP1 | S522 | ochoa|psp | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
Q14206 | RCAN2 | S112 | ochoa | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. |
Q14244 | MAP7 | S365 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
Q15003 | NCAPH | S589 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
Q15772 | SPEG | S549 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q2NKX8 | ERCC6L | S739 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
Q2TAZ0 | ATG2A | S1655 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
Q4V328 | GRIPAP1 | S692 | ochoa | GRIP1-associated protein 1 (GRASP-1) [Cleaved into: GRASP-1 C-terminal chain (30kDa C-terminus form)] | Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}. |
Q5JSZ5 | PRRC2B | S2153 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
Q5M775 | SPECC1 | S847 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
Q5SNT2 | TMEM201 | S545 | ochoa | Transmembrane protein 201 (Spindle-associated membrane protein 1) | Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000269|PubMed:35311970, ECO:0000305|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}. |
Q5SRE5 | NUP188 | S1717 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
Q5T035 | FAM120A2P | S32 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
Q5T1M5 | FKBP15 | S1114 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
Q63HR2 | TNS2 | S820 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
Q66K74 | MAP1S | S569 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
Q66K74 | MAP1S | S600 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
Q68DK7 | MSL1 | S392 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
Q68EM7 | ARHGAP17 | S625 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
Q6NY19 | KANK3 | S152 | ochoa | KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
Q6P2E9 | EDC4 | S768 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Q6P3S6 | FBXO42 | S373 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
Q6P3S6 | FBXO42 | S587 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
Q6PJ61 | FBXO46 | S21 | psp | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
Q6PJG2 | MIDEAS | S636 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
Q6WKZ4 | RAB11FIP1 | S1154 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q6ZMT1 | STAC2 | S78 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
Q6ZRI6 | C15orf39 | S108 | ochoa | Uncharacterized protein C15orf39 | None |
Q6ZW31 | SYDE1 | S39 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
Q7Z3K3 | POGZ | S425 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
Q7Z3V4 | UBE3B | S419 | ochoa | Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes (By similarity). Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC (By similarity). {ECO:0000250|UniProtKB:Q9ES34}. |
Q7Z5J4 | RAI1 | S1110 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
Q8IVF5 | TIAM2 | S209 | ochoa | Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2) | Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. {ECO:0000250, ECO:0000269|PubMed:10512681}. |
Q8IWU2 | LMTK2 | S513 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
Q8IWY8 | ZSCAN29 | S153 | ochoa | Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) | May be involved in transcriptional regulation. |
Q8IWY9 | CDAN1 | S265 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
Q8IX01 | SUGP2 | S745 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
Q8IYB3 | SRRM1 | S402 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q8IZD2 | KMT2E | S1359 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
Q8N3V7 | SYNPO | S754 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N3V7 | SYNPO | S854 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N5Y2 | MSL3 | S400 | ochoa | MSL complex subunit 3 (Male-specific lethal 3 homolog) (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:20657587, PubMed:20943666, PubMed:21217699, PubMed:30224647, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex (PubMed:20657587, PubMed:20943666). May play a role X inactivation in females (PubMed:21217699). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9WVG9, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20657587, ECO:0000269|PubMed:20943666, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:30224647, ECO:0000269|PubMed:33837287}. |
Q8N684 | CPSF7 | S48 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
Q8NFH8 | REPS2 | S550 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
Q8WU79 | SMAP2 | S177 | ochoa | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}. |
Q8WUM0 | NUP133 | S45 | ochoa|psp | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
Q8WUY9 | DEPDC1B | S436 | ochoa | DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8) | None |
Q8WV99 | ZFAND2B | S163 | ochoa | AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) | Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q91X58, ECO:0000269|PubMed:26692333}. |
Q8WX93 | PALLD | S641 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
Q8WX93 | PALLD | S728 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
Q8WYP5 | AHCTF1 | S2120 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
Q93052 | LPP | S135 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
Q96B54 | ZNF428 | S99 | ochoa | Zinc finger protein 428 (Enzyme-like protein PIT13) | None |
Q96CX2 | KCTD12 | S171 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
Q96E39 | RBMXL1 | S161 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
Q96G01 | BICD1 | S601 | ochoa | Protein bicaudal D homolog 1 (Bic-D 1) | Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex. |
Q96JE9 | MAP6 | S519 | ochoa | Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP) | Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}. |
Q96N21 | TEPSIN | S413 | ochoa | AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. |
Q96RY5 | CRAMP1 | S596 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
Q96T58 | SPEN | S3463 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99081 | TCF12 | S198 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
Q99650 | OSMR | S943 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
Q9BRD0 | BUD13 | S222 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
Q9BRP8 | PYM1 | S64 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
Q9BVC5 | C2orf49 | S193 | ochoa | Ashwin | None |
Q9BXK1 | KLF16 | S226 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
Q9BZL4 | PPP1R12C | S499 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9C0A6 | SETD5 | S865 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
Q9C0B5 | ZDHHC5 | S684 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
Q9H1B7 | IRF2BPL | T203 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
Q9H3P2 | NELFA | S225 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
Q9H3P2 | NELFA | S327 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
Q9H4X1 | RGCC | S97 | ochoa | Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32) | Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}. |
Q9H7D0 | DOCK5 | S1789 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
Q9HAW0 | BRF2 | S353 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
Q9HCM1 | RESF1 | S221 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
Q9NX95 | SYBU | S42 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
Q9NZ72 | STMN3 | S68 | ochoa|psp | Stathmin-3 (SCG10-like protein) | Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}. |
Q9NZB2 | FAM120A | S383 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
Q9P219 | CCDC88C | S1444 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
Q9P2D1 | CHD7 | S2559 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
Q9P2J2 | IGSF9 | S797 | ochoa | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}. |
Q9UBW5 | BIN2 | S357 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
Q9UJF2 | RASAL2 | S780 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Q9ULC8 | ZDHHC8 | S725 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
Q9UM11 | FZR1 | S146 | ochoa | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:14701726, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. |
Q9UPS6 | SETD1B | S1563 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
Q9Y2H5 | PLEKHA6 | S336 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
Q9Y2I7 | PIKFYVE | S76 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
Q9Y4D8 | HECTD4 | S1493 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
Q9Y4F5 | CEP170B | S972 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
Q9Y566 | SHANK1 | S2000 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
Q9Y613 | FHOD1 | S498 | ochoa|psp | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
P07814 | EPRS1 | S1122 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
Q13557 | CAMK2D | S264 | Sugiyama | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
Q96GD4 | AURKB | S43 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.001073 | 2.969 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.001567 | 2.805 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.001567 | 2.805 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.002359 | 2.627 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.002984 | 2.525 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.003197 | 2.495 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.005998 | 2.222 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.005746 | 2.241 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.004591 | 2.338 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.006053 | 2.218 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.007202 | 2.143 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.008606 | 2.065 |
R-HSA-1295596 | Spry regulation of FGF signaling | 0.012493 | 1.903 |
R-HSA-68877 | Mitotic Prometaphase | 0.011698 | 1.932 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.009614 | 2.017 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.034662 | 1.460 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.034662 | 1.460 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.034662 | 1.460 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.034662 | 1.460 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.034662 | 1.460 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.034662 | 1.460 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.034662 | 1.460 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.034662 | 1.460 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.034662 | 1.460 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.034662 | 1.460 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.034662 | 1.460 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.051543 | 1.288 |
R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.051543 | 1.288 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.059874 | 1.223 |
R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.059874 | 1.223 |
R-HSA-176417 | Phosphorylation of Emi1 | 0.068131 | 1.167 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.024102 | 1.618 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.024102 | 1.618 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.025774 | 1.589 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.040717 | 1.390 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.042768 | 1.369 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.042768 | 1.369 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.046983 | 1.328 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.046983 | 1.328 |
R-HSA-72187 | mRNA 3'-end processing | 0.016464 | 1.783 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.049146 | 1.309 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.053577 | 1.271 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.062840 | 1.202 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.065235 | 1.186 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.017325 | 1.761 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.070115 | 1.154 |
R-HSA-191650 | Regulation of gap junction activity | 0.051543 | 1.288 |
R-HSA-9620244 | Long-term potentiation | 0.031059 | 1.508 |
R-HSA-5673000 | RAF activation | 0.051344 | 1.290 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.025774 | 1.589 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.043140 | 1.365 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.051543 | 1.288 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.024102 | 1.618 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.036732 | 1.435 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.038705 | 1.412 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.038705 | 1.412 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.051344 | 1.290 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.051344 | 1.290 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.058143 | 1.235 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.023658 | 1.626 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.022268 | 1.652 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.072599 | 1.139 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.046983 | 1.328 |
R-HSA-6794361 | Neurexins and neuroligins | 0.016464 | 1.783 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.049146 | 1.309 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.068131 | 1.167 |
R-HSA-187706 | Signalling to p38 via RIT and RIN | 0.068131 | 1.167 |
R-HSA-202433 | Generation of second messenger molecules | 0.065235 | 1.186 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.046983 | 1.328 |
R-HSA-180746 | Nuclear import of Rev protein | 0.051344 | 1.290 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.024547 | 1.610 |
R-HSA-390651 | Dopamine receptors | 0.051543 | 1.288 |
R-HSA-9839394 | TGFBR3 expression | 0.031059 | 1.508 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.065235 | 1.186 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.065235 | 1.186 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.067660 | 1.170 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.043569 | 1.361 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.023201 | 1.634 |
R-HSA-68882 | Mitotic Anaphase | 0.018804 | 1.726 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.049849 | 1.302 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.019152 | 1.718 |
R-HSA-68886 | M Phase | 0.067030 | 1.174 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.060476 | 1.218 |
R-HSA-5654743 | Signaling by FGFR4 | 0.075111 | 1.124 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.062840 | 1.202 |
R-HSA-6783589 | Interleukin-6 family signaling | 0.029253 | 1.534 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.025774 | 1.589 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.046983 | 1.328 |
R-HSA-3214847 | HATs acetylate histones | 0.074237 | 1.129 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.015088 | 1.821 |
R-HSA-111933 | Calmodulin induced events | 0.055843 | 1.253 |
R-HSA-111997 | CaM pathway | 0.055843 | 1.253 |
R-HSA-9694548 | Maturation of spike protein | 0.067660 | 1.170 |
R-HSA-111996 | Ca-dependent events | 0.072599 | 1.139 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.058143 | 1.235 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.065235 | 1.186 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.077650 | 1.110 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.079002 | 1.102 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.084431 | 1.073 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.092475 | 1.034 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.092475 | 1.034 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.123953 | 0.907 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.131651 | 0.881 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.146848 | 0.833 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.154346 | 0.812 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.161780 | 0.791 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.169148 | 0.772 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.176452 | 0.753 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.183693 | 0.736 |
R-HSA-912631 | Regulation of signaling by CBL | 0.190870 | 0.719 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.190870 | 0.719 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.082809 | 1.082 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.082809 | 1.082 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.082809 | 1.082 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.232636 | 0.633 |
R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.232636 | 0.633 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.101635 | 0.993 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.136226 | 0.866 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.176096 | 0.754 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.198259 | 0.703 |
R-HSA-6802949 | Signaling by RAS mutants | 0.082809 | 1.082 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.218957 | 0.660 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.176452 | 0.753 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.154346 | 0.812 |
R-HSA-399956 | CRMPs in Sema3A signaling | 0.146848 | 0.833 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.169148 | 0.772 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.183693 | 0.736 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.080216 | 1.096 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.154378 | 0.811 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.154378 | 0.811 |
R-HSA-170968 | Frs2-mediated activation | 0.139283 | 0.856 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.176452 | 0.753 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.197984 | 0.703 |
R-HSA-169893 | Prolonged ERK activation events | 0.161780 | 0.791 |
R-HSA-6807004 | Negative regulation of MET activity | 0.197984 | 0.703 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.212028 | 0.674 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.138938 | 0.857 |
R-HSA-170984 | ARMS-mediated activation | 0.100448 | 0.998 |
R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.169148 | 0.772 |
R-HSA-191859 | snRNP Assembly | 0.118608 | 0.926 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.118608 | 0.926 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.124415 | 0.905 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.168428 | 0.774 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.148362 | 0.829 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.232636 | 0.633 |
R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.139283 | 0.856 |
R-HSA-9734767 | Developmental Cell Lineages | 0.240509 | 0.619 |
R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.092475 | 1.034 |
R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.131651 | 0.881 |
R-HSA-9706369 | Negative regulation of FLT3 | 0.161780 | 0.791 |
R-HSA-379724 | tRNA Aminoacylation | 0.121503 | 0.915 |
R-HSA-400685 | Sema4D in semaphorin signaling | 0.239386 | 0.621 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.115731 | 0.937 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.196035 | 0.708 |
R-HSA-162587 | HIV Life Cycle | 0.201430 | 0.696 |
R-HSA-5683057 | MAPK family signaling cascades | 0.224280 | 0.649 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.082809 | 1.082 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.157448 | 0.803 |
R-HSA-438064 | Post NMDA receptor activation events | 0.207861 | 0.682 |
R-HSA-8953854 | Metabolism of RNA | 0.224495 | 0.649 |
R-HSA-5654741 | Signaling by FGFR3 | 0.080216 | 1.096 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.097566 | 1.011 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.239386 | 0.621 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.112873 | 0.947 |
R-HSA-5654738 | Signaling by FGFR2 | 0.182389 | 0.739 |
R-HSA-373755 | Semaphorin interactions | 0.130289 | 0.885 |
R-HSA-5654736 | Signaling by FGFR1 | 0.110034 | 0.958 |
R-HSA-112310 | Neurotransmitter release cycle | 0.217512 | 0.663 |
R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.225827 | 0.646 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.205037 | 0.688 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.205037 | 0.688 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.173390 | 0.761 |
R-HSA-1433559 | Regulation of KIT signaling | 0.146848 | 0.833 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.148610 | 0.828 |
R-HSA-8963896 | HDL assembly | 0.146848 | 0.833 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.092475 | 1.034 |
R-HSA-391160 | Signal regulatory protein family interactions | 0.146848 | 0.833 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.082809 | 1.082 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.212028 | 0.674 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.130289 | 0.885 |
R-HSA-8848021 | Signaling by PTK6 | 0.130289 | 0.885 |
R-HSA-1489509 | DAG and IP3 signaling | 0.080216 | 1.096 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.187321 | 0.727 |
R-HSA-3371556 | Cellular response to heat stress | 0.117714 | 0.929 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.100678 | 0.997 |
R-HSA-112043 | PLC beta mediated events | 0.124415 | 0.905 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.166726 | 0.778 |
R-HSA-4839726 | Chromatin organization | 0.214359 | 0.669 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.176452 | 0.753 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.176452 | 0.753 |
R-HSA-8963898 | Plasma lipoprotein assembly | 0.232636 | 0.633 |
R-HSA-72306 | tRNA processing | 0.087113 | 1.060 |
R-HSA-74160 | Gene expression (Transcription) | 0.221595 | 0.654 |
R-HSA-1059683 | Interleukin-6 signaling | 0.139283 | 0.856 |
R-HSA-112040 | G-protein mediated events | 0.142222 | 0.847 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.112873 | 0.947 |
R-HSA-1236394 | Signaling by ERBB4 | 0.163622 | 0.786 |
R-HSA-75153 | Apoptotic execution phase | 0.082809 | 1.082 |
R-HSA-2028269 | Signaling by Hippo | 0.176452 | 0.753 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.088069 | 1.055 |
R-HSA-9006936 | Signaling by TGFB family members | 0.208209 | 0.681 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.220738 | 0.656 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.227477 | 0.643 |
R-HSA-9694635 | Translation of Structural Proteins | 0.172963 | 0.762 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.227202 | 0.644 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.246076 | 0.609 |
R-HSA-525793 | Myogenesis | 0.246076 | 0.609 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.246076 | 0.609 |
R-HSA-190236 | Signaling by FGFR | 0.249916 | 0.602 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 0.252709 | 0.597 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.252709 | 0.597 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.252709 | 0.597 |
R-HSA-70171 | Glycolysis | 0.256423 | 0.591 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.259283 | 0.586 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.259283 | 0.586 |
R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.259283 | 0.586 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.259283 | 0.586 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.259283 | 0.586 |
R-HSA-1483255 | PI Metabolism | 0.262933 | 0.580 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.262933 | 0.580 |
R-HSA-112316 | Neuronal System | 0.263559 | 0.579 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.263998 | 0.578 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.265800 | 0.575 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.269444 | 0.570 |
R-HSA-111885 | Opioid Signalling | 0.269444 | 0.570 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.272260 | 0.565 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.272260 | 0.565 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.272260 | 0.565 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.272260 | 0.565 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.272260 | 0.565 |
R-HSA-182971 | EGFR downregulation | 0.278664 | 0.555 |
R-HSA-399719 | Trafficking of AMPA receptors | 0.278664 | 0.555 |
R-HSA-211000 | Gene Silencing by RNA | 0.282462 | 0.549 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.282462 | 0.549 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.282462 | 0.549 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.285012 | 0.545 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.285012 | 0.545 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.290197 | 0.537 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.291304 | 0.536 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.291304 | 0.536 |
R-HSA-202403 | TCR signaling | 0.292214 | 0.534 |
R-HSA-390522 | Striated Muscle Contraction | 0.297541 | 0.526 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.297541 | 0.526 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.303724 | 0.518 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.309852 | 0.509 |
R-HSA-187687 | Signalling to ERKs | 0.309852 | 0.509 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.309852 | 0.509 |
R-HSA-1640170 | Cell Cycle | 0.314841 | 0.502 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.315927 | 0.500 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.315927 | 0.500 |
R-HSA-9682385 | FLT3 signaling in disease | 0.315927 | 0.500 |
R-HSA-72172 | mRNA Splicing | 0.316583 | 0.500 |
R-HSA-373760 | L1CAM interactions | 0.318124 | 0.497 |
R-HSA-70326 | Glucose metabolism | 0.321349 | 0.493 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.321949 | 0.492 |
R-HSA-68875 | Mitotic Prophase | 0.331002 | 0.480 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.333836 | 0.476 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.333836 | 0.476 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.335812 | 0.474 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.339701 | 0.469 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.339701 | 0.469 |
R-HSA-167169 | HIV Transcription Elongation | 0.339701 | 0.469 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.342743 | 0.465 |
R-HSA-162909 | Host Interactions of HIV factors | 0.343813 | 0.464 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.345515 | 0.462 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.345515 | 0.462 |
R-HSA-9607240 | FLT3 Signaling | 0.345515 | 0.462 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.351279 | 0.454 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.351279 | 0.454 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.356992 | 0.447 |
R-HSA-162582 | Signal Transduction | 0.357597 | 0.447 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.358343 | 0.446 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.359717 | 0.444 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.362655 | 0.441 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.362655 | 0.441 |
R-HSA-2172127 | DAP12 interactions | 0.368268 | 0.434 |
R-HSA-375280 | Amine ligand-binding receptors | 0.368268 | 0.434 |
R-HSA-162906 | HIV Infection | 0.371775 | 0.430 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.374163 | 0.427 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.375480 | 0.425 |
R-HSA-199991 | Membrane Trafficking | 0.377172 | 0.423 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.379348 | 0.421 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.379348 | 0.421 |
R-HSA-437239 | Recycling pathway of L1 | 0.384815 | 0.415 |
R-HSA-1483191 | Synthesis of PC | 0.384815 | 0.415 |
R-HSA-9031628 | NGF-stimulated transcription | 0.390235 | 0.409 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.391084 | 0.408 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.395607 | 0.403 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.400932 | 0.397 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.406211 | 0.391 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.411443 | 0.386 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.412636 | 0.384 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.415685 | 0.381 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.416630 | 0.380 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.416630 | 0.380 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.421771 | 0.375 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.426867 | 0.370 |
R-HSA-166520 | Signaling by NTRKs | 0.430809 | 0.366 |
R-HSA-177929 | Signaling by EGFR | 0.431919 | 0.365 |
R-HSA-193648 | NRAGE signals death through JNK | 0.431919 | 0.365 |
R-HSA-5578775 | Ion homeostasis | 0.431919 | 0.365 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.446810 | 0.350 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.448683 | 0.348 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.451632 | 0.345 |
R-HSA-1989781 | PPARA activates gene expression | 0.451632 | 0.345 |
R-HSA-1227986 | Signaling by ERBB2 | 0.451687 | 0.345 |
R-HSA-983189 | Kinesins | 0.451687 | 0.345 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.451687 | 0.345 |
R-HSA-9610379 | HCMV Late Events | 0.457503 | 0.340 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.457503 | 0.340 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.461314 | 0.336 |
R-HSA-9707616 | Heme signaling | 0.461314 | 0.336 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.461314 | 0.336 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.470772 | 0.327 |
R-HSA-109581 | Apoptosis | 0.472022 | 0.326 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.480066 | 0.319 |
R-HSA-5619102 | SLC transporter disorders | 0.486308 | 0.313 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.488584 | 0.311 |
R-HSA-167172 | Transcription of the HIV genome | 0.489197 | 0.311 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.489197 | 0.311 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.489197 | 0.311 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.498170 | 0.303 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.502597 | 0.299 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.502597 | 0.299 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.505903 | 0.296 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.505903 | 0.296 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.506986 | 0.295 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.506986 | 0.295 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.511336 | 0.291 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.511336 | 0.291 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.511413 | 0.291 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.515648 | 0.288 |
R-HSA-168255 | Influenza Infection | 0.522313 | 0.282 |
R-HSA-212436 | Generic Transcription Pathway | 0.526641 | 0.278 |
R-HSA-1483257 | Phospholipid metabolism | 0.527068 | 0.278 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.532521 | 0.274 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.532521 | 0.274 |
R-HSA-195721 | Signaling by WNT | 0.533457 | 0.273 |
R-HSA-6806834 | Signaling by MET | 0.540737 | 0.267 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.548810 | 0.261 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.556742 | 0.254 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.564536 | 0.248 |
R-HSA-9609690 | HCMV Early Events | 0.566805 | 0.247 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.566805 | 0.247 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.568381 | 0.245 |
R-HSA-1500931 | Cell-Cell communication | 0.570757 | 0.244 |
R-HSA-9679506 | SARS-CoV Infections | 0.576709 | 0.239 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.576835 | 0.239 |
R-HSA-5357801 | Programmed Cell Death | 0.591563 | 0.228 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.594373 | 0.226 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.597957 | 0.223 |
R-HSA-5653656 | Vesicle-mediated transport | 0.600358 | 0.222 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.601509 | 0.221 |
R-HSA-397014 | Muscle contraction | 0.608264 | 0.216 |
R-HSA-6807878 | COPI-mediated anterograde transport | 0.611980 | 0.213 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.611980 | 0.213 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.615410 | 0.211 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.621304 | 0.207 |
R-HSA-418990 | Adherens junctions interactions | 0.622165 | 0.206 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.622179 | 0.206 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.623824 | 0.205 |
R-HSA-69239 | Synthesis of DNA | 0.651203 | 0.186 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.657346 | 0.182 |
R-HSA-8939211 | ESR-mediated signaling | 0.663690 | 0.178 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.684043 | 0.165 |
R-HSA-9007101 | Rab regulation of trafficking | 0.686487 | 0.163 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.689262 | 0.162 |
R-HSA-9609646 | HCMV Infection | 0.689950 | 0.161 |
R-HSA-421270 | Cell-cell junction organization | 0.691900 | 0.160 |
R-HSA-913531 | Interferon Signaling | 0.694142 | 0.159 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.702775 | 0.153 |
R-HSA-2132295 | MHC class II antigen presentation | 0.702775 | 0.153 |
R-HSA-114608 | Platelet degranulation | 0.715705 | 0.145 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.723193 | 0.141 |
R-HSA-5576891 | Cardiac conduction | 0.728076 | 0.138 |
R-HSA-9909396 | Circadian clock | 0.730485 | 0.136 |
R-HSA-418594 | G alpha (i) signalling events | 0.730813 | 0.136 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.732874 | 0.135 |
R-HSA-422475 | Axon guidance | 0.738738 | 0.132 |
R-HSA-446728 | Cell junction organization | 0.740825 | 0.130 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.747485 | 0.126 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.768347 | 0.114 |
R-HSA-69242 | S Phase | 0.770402 | 0.113 |
R-HSA-69306 | DNA Replication | 0.780407 | 0.108 |
R-HSA-9675108 | Nervous system development | 0.782156 | 0.107 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.782356 | 0.107 |
R-HSA-73887 | Death Receptor Signaling | 0.782356 | 0.107 |
R-HSA-877300 | Interferon gamma signaling | 0.791844 | 0.101 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.793692 | 0.100 |
R-HSA-6798695 | Neutrophil degranulation | 0.796116 | 0.099 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.800922 | 0.096 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.807694 | 0.093 |
R-HSA-2559583 | Cellular Senescence | 0.828944 | 0.081 |
R-HSA-69275 | G2/M Transition | 0.837868 | 0.077 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.840739 | 0.075 |
R-HSA-983712 | Ion channel transport | 0.842155 | 0.075 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.853850 | 0.069 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.859469 | 0.066 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.860720 | 0.065 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.873771 | 0.059 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.873844 | 0.059 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.890616 | 0.050 |
R-HSA-2262752 | Cellular responses to stress | 0.901494 | 0.045 |
R-HSA-72766 | Translation | 0.909186 | 0.041 |
R-HSA-1280218 | Adaptive Immune System | 0.914429 | 0.039 |
R-HSA-388396 | GPCR downstream signalling | 0.923937 | 0.034 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.924852 | 0.034 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.926943 | 0.033 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.939510 | 0.027 |
R-HSA-9824446 | Viral Infection Pathways | 0.943948 | 0.025 |
R-HSA-8953897 | Cellular responses to stimuli | 0.949133 | 0.023 |
R-HSA-372790 | Signaling by GPCR | 0.953952 | 0.020 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.967939 | 0.014 |
R-HSA-9824439 | Bacterial Infection Pathways | 0.974558 | 0.011 |
R-HSA-109582 | Hemostasis | 0.975113 | 0.011 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.975462 | 0.011 |
R-HSA-449147 | Signaling by Interleukins | 0.979297 | 0.009 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.980960 | 0.008 |
R-HSA-1266738 | Developmental Biology | 0.992859 | 0.003 |
R-HSA-5663205 | Infectious disease | 0.994867 | 0.002 |
R-HSA-500792 | GPCR ligand binding | 0.995846 | 0.002 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996816 | 0.001 |
R-HSA-1643685 | Disease | 0.996904 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 0.997867 | 0.001 |
R-HSA-168256 | Immune System | 0.998072 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.998862 | 0.000 |
R-HSA-597592 | Post-translational protein modification | 0.999378 | 0.000 |
R-HSA-168249 | Innate Immune System | 0.999610 | 0.000 |
R-HSA-392499 | Metabolism of proteins | 0.999966 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.862 | 0.793 | 1 | 0.918 |
CDK18 |
0.853 | 0.804 | 1 | 0.924 |
DYRK2 |
0.852 | 0.775 | 1 | 0.874 |
CDK19 |
0.851 | 0.797 | 1 | 0.914 |
JNK2 |
0.850 | 0.828 | 1 | 0.928 |
DYRK4 |
0.850 | 0.770 | 1 | 0.928 |
HIPK4 |
0.849 | 0.617 | 1 | 0.721 |
KIS |
0.848 | 0.707 | 1 | 0.885 |
CDK3 |
0.848 | 0.726 | 1 | 0.933 |
P38D |
0.848 | 0.826 | 1 | 0.941 |
CLK3 |
0.847 | 0.574 | 1 | 0.698 |
CDK7 |
0.847 | 0.777 | 1 | 0.908 |
CDK1 |
0.846 | 0.777 | 1 | 0.920 |
P38G |
0.846 | 0.812 | 1 | 0.938 |
CDK17 |
0.845 | 0.796 | 1 | 0.932 |
CDK8 |
0.845 | 0.785 | 1 | 0.897 |
P38B |
0.844 | 0.821 | 1 | 0.902 |
ERK1 |
0.839 | 0.791 | 1 | 0.914 |
HIPK1 |
0.839 | 0.719 | 1 | 0.859 |
JNK3 |
0.837 | 0.801 | 1 | 0.915 |
CDK16 |
0.836 | 0.763 | 1 | 0.927 |
DYRK1B |
0.836 | 0.727 | 1 | 0.901 |
CLK2 |
0.834 | 0.483 | -3 | 0.858 |
DYRK1A |
0.834 | 0.676 | 1 | 0.847 |
CDK5 |
0.833 | 0.734 | 1 | 0.892 |
SRPK1 |
0.833 | 0.413 | -3 | 0.847 |
P38A |
0.832 | 0.788 | 1 | 0.869 |
CDK14 |
0.832 | 0.764 | 1 | 0.905 |
CDK13 |
0.832 | 0.734 | 1 | 0.918 |
CDK10 |
0.831 | 0.714 | 1 | 0.914 |
CDK12 |
0.830 | 0.740 | 1 | 0.927 |
MAK |
0.827 | 0.629 | -2 | 0.878 |
CDK9 |
0.825 | 0.720 | 1 | 0.915 |
HIPK3 |
0.824 | 0.685 | 1 | 0.834 |
NLK |
0.822 | 0.669 | 1 | 0.729 |
ICK |
0.822 | 0.507 | -3 | 0.907 |
JNK1 |
0.821 | 0.722 | 1 | 0.924 |
CLK1 |
0.821 | 0.458 | -3 | 0.854 |
ERK2 |
0.819 | 0.745 | 1 | 0.889 |
CLK4 |
0.819 | 0.426 | -3 | 0.870 |
DYRK3 |
0.819 | 0.570 | 1 | 0.829 |
SRPK2 |
0.816 | 0.330 | -3 | 0.787 |
CDKL5 |
0.815 | 0.307 | -3 | 0.877 |
ERK5 |
0.814 | 0.397 | 1 | 0.645 |
CDK4 |
0.811 | 0.726 | 1 | 0.928 |
CDK2 |
0.811 | 0.575 | 1 | 0.840 |
NDR2 |
0.811 | 0.133 | -3 | 0.914 |
PRKD1 |
0.809 | 0.151 | -3 | 0.906 |
CDKL1 |
0.809 | 0.272 | -3 | 0.878 |
CDK6 |
0.808 | 0.696 | 1 | 0.913 |
MOK |
0.808 | 0.560 | 1 | 0.772 |
MTOR |
0.807 | 0.214 | 1 | 0.539 |
COT |
0.807 | -0.014 | 2 | 0.834 |
PIM3 |
0.806 | 0.108 | -3 | 0.911 |
RSK2 |
0.805 | 0.130 | -3 | 0.874 |
SRPK3 |
0.803 | 0.285 | -3 | 0.814 |
PRKD2 |
0.802 | 0.127 | -3 | 0.884 |
CDC7 |
0.802 | -0.009 | 1 | 0.423 |
MOS |
0.801 | 0.065 | 1 | 0.457 |
P90RSK |
0.800 | 0.133 | -3 | 0.870 |
SKMLCK |
0.799 | 0.076 | -2 | 0.818 |
PIM1 |
0.797 | 0.135 | -3 | 0.885 |
CAMK1B |
0.795 | 0.060 | -3 | 0.916 |
NDR1 |
0.795 | 0.050 | -3 | 0.911 |
AURC |
0.794 | 0.067 | -2 | 0.618 |
PRP4 |
0.794 | 0.435 | -3 | 0.766 |
MAPKAPK2 |
0.794 | 0.089 | -3 | 0.844 |
GRK1 |
0.794 | 0.052 | -2 | 0.745 |
PRPK |
0.794 | -0.045 | -1 | 0.780 |
LATS2 |
0.793 | 0.060 | -5 | 0.754 |
ATR |
0.793 | 0.018 | 1 | 0.446 |
RSK3 |
0.793 | 0.079 | -3 | 0.862 |
CHAK2 |
0.792 | 0.027 | -1 | 0.781 |
RSK4 |
0.792 | 0.127 | -3 | 0.854 |
TBK1 |
0.790 | -0.094 | 1 | 0.345 |
NUAK2 |
0.789 | 0.071 | -3 | 0.925 |
MAPKAPK3 |
0.789 | 0.049 | -3 | 0.878 |
IKKB |
0.788 | -0.127 | -2 | 0.677 |
WNK1 |
0.788 | -0.029 | -2 | 0.846 |
PKN3 |
0.788 | 0.021 | -3 | 0.902 |
PKACG |
0.788 | 0.038 | -2 | 0.689 |
PKACB |
0.788 | 0.094 | -2 | 0.623 |
CAMK2D |
0.788 | 0.009 | -3 | 0.906 |
AMPKA1 |
0.787 | 0.021 | -3 | 0.929 |
CAMLCK |
0.787 | 0.043 | -2 | 0.789 |
LATS1 |
0.786 | 0.137 | -3 | 0.912 |
GSK3A |
0.786 | 0.262 | 4 | 0.569 |
PRKX |
0.785 | 0.118 | -3 | 0.816 |
RAF1 |
0.785 | -0.162 | 1 | 0.405 |
MARK4 |
0.785 | -0.014 | 4 | 0.811 |
PDHK4 |
0.785 | -0.158 | 1 | 0.457 |
IKKE |
0.785 | -0.130 | 1 | 0.346 |
AMPKA2 |
0.785 | 0.047 | -3 | 0.912 |
CAMK2A |
0.785 | 0.076 | 2 | 0.767 |
P70S6KB |
0.785 | 0.056 | -3 | 0.886 |
NIK |
0.784 | -0.006 | -3 | 0.914 |
DAPK2 |
0.784 | 0.032 | -3 | 0.917 |
IKKA |
0.783 | -0.051 | -2 | 0.673 |
CAMK2G |
0.783 | -0.087 | 2 | 0.778 |
TSSK1 |
0.783 | 0.044 | -3 | 0.944 |
MST4 |
0.783 | -0.033 | 2 | 0.785 |
RIPK3 |
0.781 | -0.098 | 3 | 0.681 |
PKCD |
0.781 | 0.014 | 2 | 0.711 |
PRKD3 |
0.781 | 0.078 | -3 | 0.851 |
PAK1 |
0.781 | 0.009 | -2 | 0.748 |
BMPR2 |
0.781 | -0.210 | -2 | 0.807 |
PKN2 |
0.781 | -0.023 | -3 | 0.907 |
AKT2 |
0.780 | 0.110 | -3 | 0.813 |
MSK1 |
0.780 | 0.064 | -3 | 0.847 |
CAMK2B |
0.780 | 0.021 | 2 | 0.770 |
GRK7 |
0.779 | 0.038 | 1 | 0.414 |
HUNK |
0.779 | -0.120 | 2 | 0.807 |
PKG2 |
0.779 | 0.049 | -2 | 0.634 |
GRK5 |
0.778 | -0.116 | -3 | 0.844 |
MNK1 |
0.778 | 0.043 | -2 | 0.743 |
MNK2 |
0.778 | -0.004 | -2 | 0.737 |
GCN2 |
0.778 | -0.235 | 2 | 0.755 |
TSSK2 |
0.778 | -0.018 | -5 | 0.803 |
PAK6 |
0.777 | 0.034 | -2 | 0.656 |
MASTL |
0.777 | -0.108 | -2 | 0.760 |
MSK2 |
0.777 | 0.032 | -3 | 0.842 |
QSK |
0.777 | 0.026 | 4 | 0.784 |
TGFBR2 |
0.776 | -0.098 | -2 | 0.707 |
PAK3 |
0.776 | -0.027 | -2 | 0.734 |
PDHK1 |
0.776 | -0.199 | 1 | 0.429 |
ULK2 |
0.776 | -0.232 | 2 | 0.742 |
NIM1 |
0.775 | -0.064 | 3 | 0.713 |
DNAPK |
0.775 | -0.010 | 1 | 0.409 |
AURB |
0.774 | 0.014 | -2 | 0.607 |
BMPR1B |
0.774 | -0.028 | 1 | 0.388 |
MLK2 |
0.774 | -0.073 | 2 | 0.772 |
PASK |
0.774 | 0.125 | -3 | 0.915 |
PKCB |
0.774 | -0.001 | 2 | 0.648 |
SGK3 |
0.773 | 0.056 | -3 | 0.870 |
BRSK1 |
0.773 | 0.011 | -3 | 0.886 |
NUAK1 |
0.773 | 0.026 | -3 | 0.885 |
PIM2 |
0.773 | 0.099 | -3 | 0.854 |
DSTYK |
0.773 | -0.211 | 2 | 0.836 |
MPSK1 |
0.773 | 0.147 | 1 | 0.431 |
ERK7 |
0.773 | 0.207 | 2 | 0.425 |
MELK |
0.772 | -0.010 | -3 | 0.898 |
GRK6 |
0.772 | -0.109 | 1 | 0.403 |
NEK6 |
0.771 | -0.147 | -2 | 0.765 |
DCAMKL1 |
0.771 | 0.047 | -3 | 0.893 |
SIK |
0.771 | 0.017 | -3 | 0.860 |
MLK1 |
0.770 | -0.172 | 2 | 0.740 |
CAMK4 |
0.770 | -0.064 | -3 | 0.903 |
WNK3 |
0.770 | -0.206 | 1 | 0.392 |
BCKDK |
0.770 | -0.170 | -1 | 0.676 |
TGFBR1 |
0.770 | -0.055 | -2 | 0.728 |
BRSK2 |
0.770 | -0.027 | -3 | 0.900 |
GSK3B |
0.769 | 0.117 | 4 | 0.563 |
MLK3 |
0.769 | -0.056 | 2 | 0.660 |
PKACA |
0.769 | 0.070 | -2 | 0.582 |
DLK |
0.769 | -0.169 | 1 | 0.405 |
PKCG |
0.769 | -0.020 | 2 | 0.650 |
PKCA |
0.769 | -0.009 | 2 | 0.642 |
MYLK4 |
0.769 | 0.008 | -2 | 0.711 |
PHKG1 |
0.769 | -0.032 | -3 | 0.909 |
RIPK1 |
0.768 | -0.183 | 1 | 0.386 |
SMG1 |
0.768 | -0.057 | 1 | 0.419 |
IRE1 |
0.768 | -0.102 | 1 | 0.383 |
MARK3 |
0.768 | -0.005 | 4 | 0.739 |
ULK1 |
0.768 | -0.213 | -3 | 0.790 |
PKCZ |
0.768 | -0.027 | 2 | 0.705 |
ATM |
0.768 | -0.080 | 1 | 0.410 |
ALK4 |
0.768 | -0.071 | -2 | 0.757 |
CHK1 |
0.767 | 0.017 | -3 | 0.895 |
VRK2 |
0.767 | 0.033 | 1 | 0.488 |
QIK |
0.766 | -0.075 | -3 | 0.898 |
PAK2 |
0.766 | -0.046 | -2 | 0.726 |
NEK7 |
0.765 | -0.265 | -3 | 0.823 |
FAM20C |
0.765 | -0.018 | 2 | 0.615 |
GRK4 |
0.763 | -0.170 | -2 | 0.750 |
PKR |
0.763 | -0.101 | 1 | 0.414 |
CAMK1G |
0.763 | 0.004 | -3 | 0.861 |
AURA |
0.762 | -0.016 | -2 | 0.573 |
MARK2 |
0.762 | -0.031 | 4 | 0.709 |
NEK9 |
0.762 | -0.237 | 2 | 0.777 |
AKT1 |
0.762 | 0.062 | -3 | 0.834 |
CHAK1 |
0.762 | -0.121 | 2 | 0.738 |
PKCH |
0.761 | -0.051 | 2 | 0.637 |
MAPKAPK5 |
0.760 | -0.031 | -3 | 0.821 |
TTBK2 |
0.760 | -0.194 | 2 | 0.668 |
IRE2 |
0.760 | -0.090 | 2 | 0.675 |
TLK2 |
0.760 | -0.122 | 1 | 0.388 |
YSK4 |
0.760 | -0.163 | 1 | 0.368 |
SBK |
0.760 | 0.192 | -3 | 0.715 |
MEK1 |
0.759 | -0.165 | 2 | 0.815 |
DCAMKL2 |
0.759 | 0.001 | -3 | 0.901 |
SSTK |
0.758 | -0.011 | 4 | 0.775 |
PAK4 |
0.758 | 0.010 | -2 | 0.607 |
PAK5 |
0.758 | -0.004 | -2 | 0.601 |
ANKRD3 |
0.758 | -0.257 | 1 | 0.417 |
CK1E |
0.758 | 0.002 | -3 | 0.563 |
SGK1 |
0.757 | 0.108 | -3 | 0.745 |
ACVR2B |
0.757 | -0.110 | -2 | 0.710 |
P70S6K |
0.757 | 0.027 | -3 | 0.817 |
AKT3 |
0.757 | 0.088 | -3 | 0.763 |
MST3 |
0.756 | -0.051 | 2 | 0.772 |
CAMK1D |
0.756 | 0.042 | -3 | 0.815 |
MARK1 |
0.756 | -0.053 | 4 | 0.753 |
ALK2 |
0.756 | -0.095 | -2 | 0.727 |
PLK1 |
0.756 | -0.185 | -2 | 0.698 |
ACVR2A |
0.755 | -0.118 | -2 | 0.700 |
GRK2 |
0.755 | -0.083 | -2 | 0.647 |
DRAK1 |
0.755 | -0.126 | 1 | 0.371 |
WNK4 |
0.753 | -0.112 | -2 | 0.839 |
NEK2 |
0.753 | -0.198 | 2 | 0.740 |
SMMLCK |
0.753 | -0.006 | -3 | 0.891 |
PKCT |
0.752 | -0.044 | 2 | 0.650 |
MLK4 |
0.752 | -0.144 | 2 | 0.649 |
PKCE |
0.752 | 0.020 | 2 | 0.635 |
TAO3 |
0.752 | -0.048 | 1 | 0.412 |
PINK1 |
0.752 | 0.042 | 1 | 0.572 |
BUB1 |
0.751 | 0.075 | -5 | 0.768 |
GAK |
0.751 | -0.004 | 1 | 0.443 |
PLK3 |
0.751 | -0.151 | 2 | 0.753 |
SNRK |
0.751 | -0.152 | 2 | 0.636 |
PLK4 |
0.751 | -0.160 | 2 | 0.611 |
BMPR1A |
0.751 | -0.071 | 1 | 0.372 |
CK1D |
0.750 | 0.015 | -3 | 0.513 |
LKB1 |
0.750 | -0.043 | -3 | 0.850 |
MEK5 |
0.750 | -0.189 | 2 | 0.783 |
PKCI |
0.750 | -0.040 | 2 | 0.657 |
DAPK3 |
0.750 | 0.017 | -3 | 0.893 |
PHKG2 |
0.749 | -0.058 | -3 | 0.889 |
ROCK2 |
0.748 | 0.061 | -3 | 0.887 |
IRAK4 |
0.748 | -0.138 | 1 | 0.370 |
MRCKA |
0.748 | 0.050 | -3 | 0.859 |
PDK1 |
0.747 | -0.034 | 1 | 0.420 |
MRCKB |
0.747 | 0.048 | -3 | 0.847 |
NEK5 |
0.746 | -0.186 | 1 | 0.393 |
DAPK1 |
0.746 | 0.013 | -3 | 0.879 |
PBK |
0.745 | 0.005 | 1 | 0.400 |
CK1A2 |
0.745 | -0.011 | -3 | 0.519 |
GCK |
0.745 | -0.053 | 1 | 0.403 |
CK2A2 |
0.745 | -0.057 | 1 | 0.334 |
DMPK1 |
0.745 | 0.099 | -3 | 0.869 |
MEKK2 |
0.745 | -0.172 | 2 | 0.757 |
BRAF |
0.745 | -0.188 | -4 | 0.734 |
PKN1 |
0.745 | 0.005 | -3 | 0.840 |
NEK11 |
0.744 | -0.150 | 1 | 0.404 |
CHK2 |
0.744 | 0.048 | -3 | 0.772 |
PERK |
0.744 | -0.214 | -2 | 0.751 |
MEKK3 |
0.744 | -0.220 | 1 | 0.393 |
CK1G1 |
0.743 | -0.048 | -3 | 0.534 |
ZAK |
0.743 | -0.213 | 1 | 0.370 |
CAMK1A |
0.742 | 0.041 | -3 | 0.779 |
MEKK1 |
0.742 | -0.217 | 1 | 0.390 |
MEKK6 |
0.741 | -0.099 | 1 | 0.393 |
MAP3K15 |
0.741 | -0.081 | 1 | 0.379 |
GRK3 |
0.741 | -0.082 | -2 | 0.604 |
TAO2 |
0.741 | -0.097 | 2 | 0.778 |
HPK1 |
0.740 | -0.073 | 1 | 0.400 |
TLK1 |
0.740 | -0.202 | -2 | 0.738 |
KHS1 |
0.740 | -0.022 | 1 | 0.388 |
CRIK |
0.739 | 0.083 | -3 | 0.831 |
CAMKK2 |
0.739 | -0.157 | -2 | 0.696 |
TNIK |
0.739 | -0.055 | 3 | 0.830 |
HRI |
0.739 | -0.253 | -2 | 0.763 |
CK2A1 |
0.738 | -0.056 | 1 | 0.322 |
HASPIN |
0.738 | 0.027 | -1 | 0.651 |
LOK |
0.738 | -0.073 | -2 | 0.710 |
HGK |
0.738 | -0.093 | 3 | 0.812 |
LRRK2 |
0.737 | -0.053 | 2 | 0.779 |
PKG1 |
0.737 | 0.007 | -2 | 0.557 |
KHS2 |
0.737 | -0.023 | 1 | 0.404 |
SLK |
0.735 | -0.069 | -2 | 0.667 |
CAMKK1 |
0.734 | -0.243 | -2 | 0.685 |
EEF2K |
0.734 | -0.094 | 3 | 0.782 |
MINK |
0.734 | -0.141 | 1 | 0.375 |
NEK8 |
0.732 | -0.237 | 2 | 0.747 |
PDHK3_TYR |
0.732 | 0.251 | 4 | 0.884 |
NEK4 |
0.732 | -0.206 | 1 | 0.371 |
TTBK1 |
0.731 | -0.198 | 2 | 0.590 |
ROCK1 |
0.730 | 0.026 | -3 | 0.860 |
TAK1 |
0.730 | -0.204 | 1 | 0.394 |
VRK1 |
0.730 | -0.164 | 2 | 0.803 |
MST2 |
0.729 | -0.190 | 1 | 0.388 |
NEK1 |
0.729 | -0.185 | 1 | 0.370 |
STK33 |
0.729 | -0.146 | 2 | 0.591 |
IRAK1 |
0.728 | -0.275 | -1 | 0.662 |
PLK2 |
0.727 | -0.094 | -3 | 0.720 |
LIMK2_TYR |
0.724 | 0.185 | -3 | 0.909 |
MST1 |
0.723 | -0.177 | 1 | 0.372 |
YSK1 |
0.722 | -0.157 | 2 | 0.737 |
TESK1_TYR |
0.721 | 0.086 | 3 | 0.826 |
PDHK4_TYR |
0.721 | 0.101 | 2 | 0.853 |
YANK3 |
0.719 | -0.044 | 2 | 0.397 |
BIKE |
0.719 | -0.041 | 1 | 0.394 |
PKMYT1_TYR |
0.717 | 0.114 | 3 | 0.791 |
MAP2K4_TYR |
0.717 | 0.044 | -1 | 0.779 |
AAK1 |
0.717 | 0.017 | 1 | 0.368 |
MAP2K6_TYR |
0.716 | 0.044 | -1 | 0.785 |
MEK2 |
0.716 | -0.263 | 2 | 0.781 |
ASK1 |
0.716 | -0.128 | 1 | 0.372 |
OSR1 |
0.715 | -0.125 | 2 | 0.755 |
NEK3 |
0.715 | -0.180 | 1 | 0.374 |
RIPK2 |
0.714 | -0.273 | 1 | 0.343 |
MAP2K7_TYR |
0.713 | -0.068 | 2 | 0.826 |
PDHK1_TYR |
0.711 | -0.019 | -1 | 0.795 |
MYO3B |
0.711 | -0.115 | 2 | 0.747 |
CK1A |
0.711 | -0.032 | -3 | 0.419 |
TAO1 |
0.711 | -0.118 | 1 | 0.360 |
BMPR2_TYR |
0.711 | -0.009 | -1 | 0.778 |
ALPHAK3 |
0.710 | -0.103 | -1 | 0.679 |
TTK |
0.709 | -0.141 | -2 | 0.726 |
PINK1_TYR |
0.706 | -0.145 | 1 | 0.444 |
MYO3A |
0.706 | -0.140 | 1 | 0.384 |
LIMK1_TYR |
0.704 | -0.029 | 2 | 0.803 |
EPHA6 |
0.703 | -0.082 | -1 | 0.760 |
RET |
0.703 | -0.131 | 1 | 0.407 |
MST1R |
0.699 | -0.121 | 3 | 0.740 |
DDR1 |
0.699 | -0.107 | 4 | 0.802 |
EPHB4 |
0.699 | -0.112 | -1 | 0.728 |
JAK2 |
0.698 | -0.127 | 1 | 0.411 |
TNK2 |
0.698 | -0.067 | 3 | 0.690 |
NEK10_TYR |
0.697 | -0.087 | 1 | 0.362 |
CSF1R |
0.697 | -0.097 | 3 | 0.719 |
ROS1 |
0.696 | -0.124 | 3 | 0.682 |
TXK |
0.696 | -0.067 | 1 | 0.378 |
ABL2 |
0.696 | -0.098 | -1 | 0.702 |
TYK2 |
0.695 | -0.221 | 1 | 0.395 |
YES1 |
0.695 | -0.095 | -1 | 0.787 |
TYRO3 |
0.695 | -0.174 | 3 | 0.718 |
TNK1 |
0.694 | -0.045 | 3 | 0.705 |
ABL1 |
0.693 | -0.103 | -1 | 0.695 |
FGR |
0.693 | -0.126 | 1 | 0.386 |
JAK3 |
0.693 | -0.145 | 1 | 0.396 |
EPHA4 |
0.692 | -0.089 | 2 | 0.762 |
STLK3 |
0.692 | -0.235 | 1 | 0.348 |
FGFR2 |
0.691 | -0.083 | 3 | 0.712 |
LCK |
0.690 | -0.091 | -1 | 0.769 |
JAK1 |
0.690 | -0.091 | 1 | 0.370 |
DDR2 |
0.689 | -0.000 | 3 | 0.641 |
TNNI3K_TYR |
0.689 | -0.064 | 1 | 0.399 |
HCK |
0.688 | -0.153 | -1 | 0.760 |
BLK |
0.688 | -0.082 | -1 | 0.769 |
TEK |
0.687 | -0.067 | 3 | 0.645 |
INSRR |
0.687 | -0.161 | 3 | 0.654 |
SRMS |
0.687 | -0.178 | 1 | 0.384 |
KDR |
0.686 | -0.115 | 3 | 0.684 |
FGFR1 |
0.686 | -0.093 | 3 | 0.673 |
ITK |
0.686 | -0.151 | -1 | 0.712 |
KIT |
0.685 | -0.151 | 3 | 0.720 |
FER |
0.685 | -0.215 | 1 | 0.407 |
EPHB1 |
0.684 | -0.188 | 1 | 0.384 |
MERTK |
0.684 | -0.157 | 3 | 0.699 |
FYN |
0.684 | -0.074 | -1 | 0.772 |
EPHB3 |
0.683 | -0.170 | -1 | 0.712 |
YANK2 |
0.683 | -0.074 | 2 | 0.410 |
AXL |
0.683 | -0.175 | 3 | 0.695 |
MET |
0.682 | -0.127 | 3 | 0.715 |
EPHB2 |
0.681 | -0.171 | -1 | 0.702 |
BMX |
0.681 | -0.128 | -1 | 0.648 |
FGFR3 |
0.680 | -0.104 | 3 | 0.686 |
FLT3 |
0.680 | -0.215 | 3 | 0.716 |
CK1G3 |
0.679 | -0.063 | -3 | 0.370 |
WEE1_TYR |
0.679 | -0.125 | -1 | 0.657 |
EPHA7 |
0.678 | -0.140 | 2 | 0.750 |
PDGFRB |
0.678 | -0.257 | 3 | 0.723 |
PTK2B |
0.676 | -0.111 | -1 | 0.690 |
TEC |
0.676 | -0.177 | -1 | 0.653 |
EPHA1 |
0.675 | -0.165 | 3 | 0.686 |
EPHA3 |
0.675 | -0.166 | 2 | 0.732 |
PDGFRA |
0.675 | -0.239 | 3 | 0.722 |
FRK |
0.675 | -0.167 | -1 | 0.748 |
ERBB2 |
0.675 | -0.194 | 1 | 0.372 |
FLT1 |
0.674 | -0.169 | -1 | 0.715 |
BTK |
0.674 | -0.246 | -1 | 0.678 |
PTK2 |
0.673 | -0.053 | -1 | 0.717 |
ALK |
0.672 | -0.199 | 3 | 0.612 |
LTK |
0.672 | -0.200 | 3 | 0.647 |
SRC |
0.671 | -0.128 | -1 | 0.756 |
LYN |
0.671 | -0.162 | 3 | 0.635 |
PTK6 |
0.670 | -0.243 | -1 | 0.640 |
INSR |
0.670 | -0.191 | 3 | 0.640 |
EGFR |
0.670 | -0.133 | 1 | 0.321 |
NTRK1 |
0.670 | -0.254 | -1 | 0.705 |
EPHA8 |
0.669 | -0.134 | -1 | 0.707 |
NTRK3 |
0.669 | -0.175 | -1 | 0.666 |
EPHA5 |
0.669 | -0.163 | 2 | 0.749 |
SYK |
0.668 | -0.084 | -1 | 0.693 |
FLT4 |
0.668 | -0.209 | 3 | 0.673 |
FGFR4 |
0.667 | -0.131 | -1 | 0.654 |
CK1G2 |
0.666 | -0.058 | -3 | 0.459 |
CSK |
0.666 | -0.162 | 2 | 0.756 |
MATK |
0.665 | -0.148 | -1 | 0.624 |
NTRK2 |
0.664 | -0.268 | 3 | 0.669 |
ERBB4 |
0.662 | -0.103 | 1 | 0.330 |
EPHA2 |
0.659 | -0.150 | -1 | 0.661 |
ZAP70 |
0.656 | -0.063 | -1 | 0.625 |
MUSK |
0.655 | -0.187 | 1 | 0.313 |
IGF1R |
0.654 | -0.185 | 3 | 0.574 |
FES |
0.644 | -0.181 | -1 | 0.622 |