Motif 224 (n=163)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6ND36 | FAM83G | S650 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O14686 | KMT2D | S4974 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O43159 | RRP8 | S223 | ochoa | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| O60292 | SIPA1L3 | S1433 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60292 | SIPA1L3 | S1707 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60343 | TBC1D4 | S106 | ochoa | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}. |
| O60749 | SNX2 | S97 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75030 | MITF | S180 | psp | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
| O75064 | DENND4B | S736 | ochoa | DENN domain-containing protein 4B | Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| O75116 | ROCK2 | S1362 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75128 | COBL | S347 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75147 | OBSL1 | S120 | ochoa | Obscurin-like protein 1 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| O75376 | NCOR1 | S1543 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75385 | ULK1 | S413 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O95429 | BAG4 | S245 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95613 | PCNT | S3242 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95817 | BAG3 | S381 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P00533 | EGFR | S1130 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P06401 | PGR | S162 | ochoa|psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P11532 | DMD | S3549 | ochoa | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P14635 | CCNB1 | S116 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P14635 | CCNB1 | S126 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P17096 | HMGA1 | S44 | ochoa|psp | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| P20823 | HNF1A | S304 | ochoa | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
| P22314 | UBA1 | S24 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P26651 | ZFP36 | S88 | ochoa|psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P29590 | PML | S48 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P31751 | AKT2 | S126 | ochoa|psp | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta) | Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1). AKT mediates the antiapoptotic effects of IGF1. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development (PubMed:21432781, PubMed:21620960). In response to lysophosphatidic acid stimulation, inhibits the ciliogenesis cascade. In this context, phosphorylates WDR44, hence stabilizing its interaction with Rab11 and preventing the formation of the ciliogenic Rab11-FIP3-RAB3IP complex. Also phosphorylates RAB3IP/Rabin8, thus may affect RAB3IP guanine nucleotide exchange factor (GEF) activity toward Rab8, which is important for cilia growth (PubMed:31204173). Phosphorylates PKP1, facilitating its interaction with YWHAG and translocation to the nucleus, ultimately resulting in a reduction in keratinocyte intercellular adhesion (By similarity). Phosphorylation of PKP1 increases PKP1 protein stability, translocation to the cytoplasm away from desmosome plaques and PKP1-driven cap-dependent translation (PubMed:23444369). {ECO:0000250|UniProtKB:Q60823, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:31204173, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.; FUNCTION: Several AKT2-specific substrates have been identified, including ANKRD2, C2CD5, CLK2 and PITX2. May play a role in myoblast differentiation. In this context, may act through PITX2 phosphorylation. Unphosphorylated PITX2 associates with an ELAVL1/HuR-containing complex, which stabilizes CCND1 cyclin mRNA, ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation (By similarity). Also involved in the negative regulation of myogenesis in response to stress conditions. In this context, acts by phosphorylating ANKRD2 (By similarity). May also be a key regulator of glucose uptake. Regulates insulin-stimulated glucose transport by the increase of glucose transporter GLUT4 translocation from intracellular stores to the plasma membrane. In this context, acts by phosphorylating C2CD5/CDP138 on 'Ser-197' in insulin-stimulated adipocytes (By similarity). Through the phosphorylation of CLK2 on 'Thr-343', involved in insulin-regulated suppression of hepatic gluconeogenesis (By similarity). {ECO:0000250|UniProtKB:Q60823}. |
| P40337 | VHL | S68 | ochoa|psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P42566 | EPS15 | S108 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42695 | NCAPD3 | S1474 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P46821 | MAP1B | S2209 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S2211 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P50616 | TOB1 | S152 | ochoa|psp | Protein Tob1 (Transducer of erbB-2 1) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}. |
| P50895 | BCAM | S600 | ochoa | Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}. |
| P51532 | SMARCA4 | S31 | psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P51825 | AFF1 | S216 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P53814 | SMTN | S245 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P78524 | DENND2B | S84 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q01196 | RUNX1 | S229 | ochoa | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| Q01826 | SATB1 | S469 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q03164 | KMT2A | S518 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07157 | TJP1 | S968 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q10586 | DBP | S161 | ochoa | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Q12873 | CHD3 | S328 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q13094 | LCP2 | S339 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13322 | GRB10 | S150 | ochoa|psp | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13469 | NFATC2 | S326 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13487 | SNAPC2 | S193 | ochoa | snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| Q13505 | MTX1 | S43 | ochoa | Metaxin-1 (Mitochondrial outer membrane import complex protein 1) | Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). {ECO:0000250}. |
| Q13522 | PPP1R1A | S67 | ochoa|psp | Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
| Q13586 | STIM1 | S616 | ochoa | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q14526 | HIC1 | S313 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14676 | MDC1 | S793 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14934 | NFATC4 | S264 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q15583 | TGIF1 | S286 | ochoa | Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1) | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Q16538 | GPR162 | S524 | ochoa | Probable G-protein coupled receptor 162 (Gene-rich cluster gene A protein) | Orphan receptor. |
| Q16643 | DBN1 | S341 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q2NKX8 | ERCC6L | S1188 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q3MIN7 | RGL3 | S52 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q3MIN7 | RGL3 | S601 | ochoa | Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1 (By similarity). {ECO:0000250}. |
| Q4ZG55 | GREB1 | S1160 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
| Q5EBL4 | RILPL1 | S346 | ochoa | RILP-like protein 1 (Rab-interacting lysosomal-like protein 1) | Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). {ECO:0000250|UniProtKB:D3ZUQ0, ECO:0000250|UniProtKB:Q9JJC6, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:30398148}. |
| Q5JSZ5 | PRRC2B | S2161 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T1R4 | HIVEP3 | S2127 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T2W1 | PDZK1 | S364 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). {ECO:0000250}. |
| Q5T481 | RBM20 | S1048 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5TGY3 | AHDC1 | S369 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
| Q5VZ89 | DENND4C | S703 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q68DK7 | MSL1 | S450 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IPM2 | IQCE | S583 | ochoa | IQ domain-containing protein E | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}. |
| Q6P1M3 | LLGL2 | S680 | ochoa | LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2) | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Q6P4F7 | ARHGAP11A | S318 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PII3 | CCDC174 | S432 | ochoa | Coiled-coil domain-containing protein 174 | Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}. |
| Q6PJG9 | LRFN4 | S575 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
| Q6W2J9 | BCOR | S1122 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6XE24 | RBMS3 | S41 | ochoa | RNA-binding motif, single-stranded-interacting protein 3 | Binds poly(A) and poly(U) oligoribonucleotides. {ECO:0000269|PubMed:10675610}. |
| Q6XZF7 | DNMBP | S622 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZMD2 | SPNS3 | S21 | ochoa | Protein spinster homolog 3 | Sphingolipid transporter. {ECO:0000250}. |
| Q6ZUM4 | ARHGAP27 | S456 | ochoa | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. |
| Q7KZ85 | SUPT6H | S1527 | ochoa | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}. |
| Q7KZI7 | MARK2 | S569 | ochoa|psp | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z5J4 | RAI1 | S892 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86UU1 | PHLDB1 | S489 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q8IWY9 | CDAN1 | S277 | ochoa | Codanin-1 | May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}. |
| Q8IX07 | ZFPM1 | S84 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IYB3 | SRRM1 | S685 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N2M8 | CLASRP | S101 | ochoa | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity). {ECO:0000250}. |
| Q8N3V7 | SYNPO | S525 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N684 | CPSF7 | S60 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N8Z6 | DCBLD1 | S635 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NC74 | RBBP8NL | S254 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8ND56 | LSM14A | S216 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDX1 | PSD4 | S443 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NDX1 | PSD4 | S469 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
| Q8NFH8 | REPS2 | S489 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8NG27 | PJA1 | S265 | ochoa | E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}. |
| Q8TAP8 | PPP1R35 | S47 | ochoa | Protein phosphatase 1 regulatory subunit 35 | During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. |
| Q8TD26 | CHD6 | S2680 | ochoa | Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein) | ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269|PubMed:16314513, ECO:0000269|PubMed:17027977, ECO:0000269|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269|PubMed:20631145, ECO:0000269|PubMed:21899694, ECO:0000269|PubMed:23408615}. |
| Q8WWM7 | ATXN2L | S391 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWN8 | ARAP3 | S1474 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q8WXI9 | GATAD2B | S223 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q8WXX7 | AUTS2 | S951 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q92574 | TSC1 | Y406 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92918 | MAP4K1 | S405 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q96BF3 | TMIGD2 | S238 | psp | Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1) | Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}. |
| Q96EV2 | RBM33 | S849 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96JM3 | CHAMP1 | S214 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KM6 | ZNF512B | S665 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
| Q96KQ4 | PPP1R13B | S477 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96PC5 | MIA2 | S1204 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PE2 | ARHGEF17 | S147 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96PX6 | CCDC85A | S313 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q96RT1 | ERBIN | S1128 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RY5 | CRAMP1 | S70 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99081 | TCF12 | S208 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99700 | ATXN2 | S692 | psp | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BQG0 | MYBBP1A | S1232 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BTC0 | DIDO1 | S1746 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BUA3 | SPINDOC | S61 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BWG4 | SSBP4 | S350 | ochoa | Single-stranded DNA-binding protein 4 | None |
| Q9BWG6 | SCNM1 | S173 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
| Q9BWH6 | RPAP1 | S80 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
| Q9BWW4 | SSBP3 | S355 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Q9C073 | FAM117A | S327 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0C9 | UBE2O | S322 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0D0 | PHACTR1 | S237 | ochoa | Phosphatase and actin regulator 1 | Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250|UniProtKB:Q2M3X8, ECO:0000269|PubMed:21798305, ECO:0000269|PubMed:21939755}. |
| Q9C0D5 | TANC1 | S305 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0E8 | LNPK | S194 | ochoa | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:30032983}. |
| Q9C0H5 | ARHGAP39 | S366 | ochoa | Rho GTPase-activating protein 39 | None |
| Q9GZR1 | SENP6 | S362 | ochoa | Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. |
| Q9GZU1 | MCOLN1 | S29 | ochoa | Mucolipin-1 (ML1) (MG-2) (Mucolipidin) (Transient receptor potential channel mucolipin 1) (TRPML1) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:18794901, PubMed:25720963, PubMed:27623384, PubMed:29019983). Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:25720963, PubMed:29019983). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:14749347, PubMed:15336987, PubMed:25720963, PubMed:27623384, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). {ECO:0000250|UniProtKB:Q99J21, ECO:0000269|PubMed:12459486, ECO:0000269|PubMed:14749347, ECO:0000269|PubMed:15336987, ECO:0000269|PubMed:16978393, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:25733853, ECO:0000269|PubMed:27357649, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:27787197, ECO:0000269|PubMed:29019983, ECO:0000305|PubMed:11013137}.; FUNCTION: May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase. {ECO:0000305|PubMed:21256127}. |
| Q9GZV9 | FGF23 | S212 | psp | Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] | Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}. |
| Q9GZY8 | MFF | S202 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H079 | KATNBL1 | S89 | ochoa | KATNB1-like protein 1 (Katanin p80 subunit B-like 1) | Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}. |
| Q9H1B7 | IRF2BPL | S215 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H2D6 | TRIOBP | S88 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H7N4 | SCAF1 | S674 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H7P9 | PLEKHG2 | S90 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H814 | PHAX | S103 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H987 | SYNPO2L | S178 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9H9J4 | USP42 | S1007 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
| Q9NP31 | SH2D2A | Y280 | psp | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Q9NQW6 | ANLN | S182 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NSC2 | SALL1 | S586 | ochoa | Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}. |
| Q9NYB9 | ABI2 | S183 | ochoa|psp | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYV4 | CDK12 | S644 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P266 | JCAD | S1198 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P2Y4 | ZNF219 | T259 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UDY2 | TJP2 | S499 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UIF9 | BAZ2A | S1370 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UKE5 | TNIK | S680 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9UQ35 | SRRM2 | S377 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S387 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S454 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2F5 | ICE1 | S1692 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y534 | CSDC2 | S19 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q9Y666 | SLC12A7 | S50 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q4VCS5 | AMOT | S852 | EPSD | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| P10636 | MAPT | S575 | GPS6|ELM|EPSD | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| Q14694 | USP10 | S253 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
| P49591 | SARS1 | S298 | Sugiyama | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}. |
| Q96J92 | WNK4 | S122 | Sugiyama | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) | Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250|UniProtKB:Q80UE6, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:20525693, ECO:0000269|PubMed:22989884}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000031 | 4.506 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000117 | 3.931 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.000113 | 3.946 |
| R-HSA-74160 | Gene expression (Transcription) | 0.000255 | 3.594 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.001008 | 2.997 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.001023 | 2.990 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.001124 | 2.949 |
| R-HSA-212436 | Generic Transcription Pathway | 0.001934 | 2.714 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.002234 | 2.651 |
| R-HSA-2028269 | Signaling by Hippo | 0.002166 | 2.664 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.003841 | 2.416 |
| R-HSA-75153 | Apoptotic execution phase | 0.003622 | 2.441 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.004214 | 2.375 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.004766 | 2.322 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.006134 | 2.212 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.006134 | 2.212 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.007234 | 2.141 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.008545 | 2.068 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.008449 | 2.073 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.008728 | 2.059 |
| R-HSA-8939211 | ESR-mediated signaling | 0.009954 | 2.002 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.010480 | 1.980 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.010550 | 1.977 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.011725 | 1.931 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.013903 | 1.857 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.015082 | 1.822 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.016524 | 1.782 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.017868 | 1.748 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.018389 | 1.735 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.017173 | 1.765 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.017625 | 1.754 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.016524 | 1.782 |
| R-HSA-109581 | Apoptosis | 0.018056 | 1.743 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.018407 | 1.735 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.044682 | 1.350 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.044682 | 1.350 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.044682 | 1.350 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.044682 | 1.350 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.044682 | 1.350 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.044682 | 1.350 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.044682 | 1.350 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.044682 | 1.350 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.044682 | 1.350 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.044682 | 1.350 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.044682 | 1.350 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.055539 | 1.255 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.055539 | 1.255 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.055539 | 1.255 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.055539 | 1.255 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.066273 | 1.179 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.076886 | 1.114 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.076886 | 1.114 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.076886 | 1.114 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.076886 | 1.114 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.087379 | 1.059 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.087379 | 1.059 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.087379 | 1.059 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.097753 | 1.010 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.097753 | 1.010 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.097753 | 1.010 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.097753 | 1.010 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.097753 | 1.010 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.118150 | 0.928 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.118150 | 0.928 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.118150 | 0.928 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.028934 | 1.539 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.128177 | 0.892 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.046756 | 1.330 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.157580 | 0.802 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.167160 | 0.777 |
| R-HSA-190375 | FGFR2c ligand binding and activation | 0.176632 | 0.753 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.061357 | 1.212 |
| R-HSA-190372 | FGFR3c ligand binding and activation | 0.185997 | 0.730 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.185997 | 0.730 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.185997 | 0.730 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.195256 | 0.709 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.195256 | 0.709 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.195256 | 0.709 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.195256 | 0.709 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.222408 | 0.653 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.043813 | 1.358 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.231255 | 0.636 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.240002 | 0.620 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.248650 | 0.604 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.248650 | 0.604 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.257199 | 0.590 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.265652 | 0.576 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.265652 | 0.576 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.274010 | 0.562 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.274010 | 0.562 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.274010 | 0.562 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.076649 | 1.115 |
| R-HSA-72187 | mRNA 3'-end processing | 0.150607 | 0.822 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.290442 | 0.537 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.298519 | 0.525 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.257199 | 0.590 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.257199 | 0.590 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.222408 | 0.653 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.222408 | 0.653 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.044789 | 1.349 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.096144 | 1.017 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.064441 | 1.191 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.061357 | 1.212 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.108010 | 0.967 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.257199 | 0.590 |
| R-HSA-182971 | EGFR downregulation | 0.067577 | 1.170 |
| R-HSA-177929 | Signaling by EGFR | 0.166563 | 0.778 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.240002 | 0.620 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.248650 | 0.604 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.274010 | 0.562 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.298519 | 0.525 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.023442 | 1.630 |
| R-HSA-180292 | GAB1 signalosome | 0.231255 | 0.636 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.127325 | 0.895 |
| R-HSA-191650 | Regulation of gap junction activity | 0.066273 | 1.179 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.118150 | 0.928 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.213460 | 0.671 |
| R-HSA-162592 | Integration of provirus | 0.157580 | 0.802 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.062854 | 1.202 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.097858 | 1.009 |
| R-HSA-165158 | Activation of AKT2 | 0.076886 | 1.114 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.167160 | 0.777 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.176632 | 0.753 |
| R-HSA-190239 | FGFR3 ligand binding and activation | 0.195256 | 0.709 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.112336 | 0.949 |
| R-HSA-109704 | PI3K Cascade | 0.142751 | 0.845 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.089436 | 1.048 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.184129 | 0.735 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.043813 | 1.358 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.062854 | 1.202 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.036286 | 1.440 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.213460 | 0.671 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.279801 | 0.553 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.266279 | 0.575 |
| R-HSA-9609690 | HCMV Early Events | 0.232426 | 0.634 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.231255 | 0.636 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.248650 | 0.604 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.066273 | 1.179 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.066273 | 1.179 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.066273 | 1.179 |
| R-HSA-109703 | PKB-mediated events | 0.087379 | 1.059 |
| R-HSA-165160 | PDE3B signalling | 0.087379 | 1.059 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.087379 | 1.059 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.128177 | 0.892 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.138089 | 0.860 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.147890 | 0.830 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.157580 | 0.802 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.167160 | 0.777 |
| R-HSA-190322 | FGFR4 ligand binding and activation | 0.176632 | 0.753 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.176632 | 0.753 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.176632 | 0.753 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.061357 | 1.212 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.204410 | 0.689 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.080603 | 1.094 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.213460 | 0.671 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.231255 | 0.636 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.101425 | 0.994 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.274010 | 0.562 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.186889 | 0.728 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.231255 | 0.636 |
| R-HSA-112399 | IRS-mediated signalling | 0.170597 | 0.768 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.222408 | 0.653 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.049863 | 1.302 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.283134 | 0.548 |
| R-HSA-9909396 | Circadian clock | 0.028385 | 1.547 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.241009 | 0.618 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.108010 | 0.967 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.222408 | 0.653 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.108665 | 0.964 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 0.257199 | 0.590 |
| R-HSA-9707616 | Heme signaling | 0.190997 | 0.719 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.236806 | 0.626 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.231018 | 0.636 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.101425 | 0.994 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.101425 | 0.994 |
| R-HSA-74713 | IRS activation | 0.076886 | 1.114 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.097753 | 1.010 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.024479 | 1.611 |
| R-HSA-164843 | 2-LTR circle formation | 0.138089 | 0.860 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.147890 | 0.830 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.157580 | 0.802 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.157580 | 0.802 |
| R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 0.176632 | 0.753 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.231255 | 0.636 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.240002 | 0.620 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.186889 | 0.728 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.298519 | 0.525 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.083972 | 1.076 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 0.231255 | 0.636 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.290442 | 0.537 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.298519 | 0.525 |
| R-HSA-1632852 | Macroautophagy | 0.270559 | 0.568 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.031093 | 1.507 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.138089 | 0.860 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.185997 | 0.730 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.153873 | 0.813 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.050350 | 1.298 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.271230 | 0.567 |
| R-HSA-9843745 | Adipogenesis | 0.237035 | 0.625 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.257199 | 0.590 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.097753 | 1.010 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.108010 | 0.967 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.108010 | 0.967 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.128177 | 0.892 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.044013 | 1.356 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.157580 | 0.802 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.167160 | 0.777 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.240002 | 0.620 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.282273 | 0.549 |
| R-HSA-9839394 | TGFBR3 expression | 0.298519 | 0.525 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.241009 | 0.618 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.199247 | 0.701 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.174648 | 0.758 |
| R-HSA-186712 | Regulation of beta-cell development | 0.178714 | 0.748 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.234931 | 0.629 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.203388 | 0.692 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.112555 | 0.949 |
| R-HSA-199991 | Membrane Trafficking | 0.044539 | 1.351 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.147890 | 0.830 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.167160 | 0.777 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.167160 | 0.777 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.167160 | 0.777 |
| R-HSA-2033514 | FGFR3 mutant receptor activation | 0.176632 | 0.753 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.176632 | 0.753 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.185997 | 0.730 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.195256 | 0.709 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.195256 | 0.709 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.195256 | 0.709 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.248650 | 0.604 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.076649 | 1.115 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.145560 | 0.837 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.047025 | 1.328 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.061672 | 1.210 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.140289 | 0.853 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.155605 | 0.808 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.176632 | 0.753 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.185997 | 0.730 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.112336 | 0.949 |
| R-HSA-194138 | Signaling by VEGF | 0.077928 | 1.108 |
| R-HSA-4839726 | Chromatin organization | 0.036033 | 1.443 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.073997 | 1.131 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.064441 | 1.191 |
| R-HSA-9659379 | Sensory processing of sound | 0.262064 | 0.582 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.070763 | 1.150 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.181287 | 0.742 |
| R-HSA-74749 | Signal attenuation | 0.138089 | 0.860 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.147890 | 0.830 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.090836 | 1.042 |
| R-HSA-8854214 | TBC/RABGAPs | 0.116038 | 0.935 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.265652 | 0.576 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.166563 | 0.778 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.215867 | 0.666 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.224225 | 0.649 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.032986 | 1.482 |
| R-HSA-165159 | MTOR signalling | 0.112336 | 0.949 |
| R-HSA-162582 | Signal Transduction | 0.025269 | 1.597 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.105028 | 0.979 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.278922 | 0.555 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.028934 | 1.539 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.274010 | 0.562 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.182795 | 0.738 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.224225 | 0.649 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.027707 | 1.557 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.024479 | 1.611 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.167160 | 0.777 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.195256 | 0.709 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.166563 | 0.778 |
| R-HSA-9607240 | FLT3 Signaling | 0.105028 | 0.979 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.024479 | 1.611 |
| R-HSA-5635838 | Activation of SMO | 0.204410 | 0.689 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.274010 | 0.562 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.128177 | 0.892 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.138089 | 0.860 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.249425 | 0.603 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.166563 | 0.778 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.182795 | 0.738 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.192725 | 0.715 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.213460 | 0.671 |
| R-HSA-445144 | Signal transduction by L1 | 0.248650 | 0.604 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.127407 | 0.895 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.248650 | 0.604 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.265652 | 0.576 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.067355 | 1.172 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.054745 | 1.262 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.044013 | 1.356 |
| R-HSA-6807070 | PTEN Regulation | 0.104973 | 0.979 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.224225 | 0.649 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.257850 | 0.589 |
| R-HSA-9945266 | Differentiation of T cells | 0.204410 | 0.689 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.204410 | 0.689 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.236806 | 0.626 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.094328 | 1.025 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.282273 | 0.549 |
| R-HSA-75893 | TNF signaling | 0.166563 | 0.778 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.044013 | 1.356 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.232426 | 0.634 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.176632 | 0.753 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.166563 | 0.778 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.222408 | 0.653 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.119771 | 0.922 |
| R-HSA-418990 | Adherens junctions interactions | 0.289742 | 0.538 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.185997 | 0.730 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.298519 | 0.525 |
| R-HSA-5357801 | Programmed Cell Death | 0.045708 | 1.340 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.240002 | 0.620 |
| R-HSA-73887 | Death Receptor Signaling | 0.135689 | 0.867 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.134988 | 0.870 |
| R-HSA-9830369 | Kidney development | 0.211699 | 0.674 |
| R-HSA-2262752 | Cellular responses to stress | 0.301005 | 0.521 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.301468 | 0.521 |
| R-HSA-9663891 | Selective autophagy | 0.304151 | 0.517 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.306504 | 0.514 |
| R-HSA-525793 | Myogenesis | 0.306504 | 0.514 |
| R-HSA-3295583 | TRP channels | 0.306504 | 0.514 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.313892 | 0.503 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.314399 | 0.503 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.314399 | 0.503 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.314399 | 0.503 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.314399 | 0.503 |
| R-HSA-8949613 | Cristae formation | 0.314399 | 0.503 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.314399 | 0.503 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.314399 | 0.503 |
| R-HSA-1266738 | Developmental Biology | 0.317260 | 0.499 |
| R-HSA-9612973 | Autophagy | 0.320110 | 0.495 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.322205 | 0.492 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.322205 | 0.492 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.322205 | 0.492 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.326329 | 0.486 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.329922 | 0.482 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.329922 | 0.482 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.329922 | 0.482 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.329922 | 0.482 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.329922 | 0.482 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.329922 | 0.482 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.332549 | 0.478 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.333378 | 0.477 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.337551 | 0.472 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.337551 | 0.472 |
| R-HSA-2424491 | DAP12 signaling | 0.337551 | 0.472 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.337551 | 0.472 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.337551 | 0.472 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.337551 | 0.472 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.345095 | 0.462 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.345095 | 0.462 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.345095 | 0.462 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.345802 | 0.461 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.349927 | 0.456 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.358151 | 0.446 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.359926 | 0.444 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.359926 | 0.444 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.359926 | 0.444 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.359926 | 0.444 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.359926 | 0.444 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.366337 | 0.436 |
| R-HSA-390522 | Striated Muscle Contraction | 0.367216 | 0.435 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.367216 | 0.435 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.367216 | 0.435 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.370415 | 0.431 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.370415 | 0.431 |
| R-HSA-9609646 | HCMV Infection | 0.371992 | 0.429 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.374423 | 0.427 |
| R-HSA-5205647 | Mitophagy | 0.374423 | 0.427 |
| R-HSA-421270 | Cell-cell junction organization | 0.374571 | 0.426 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.375954 | 0.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.375954 | 0.425 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.375954 | 0.425 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.381549 | 0.418 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.381549 | 0.418 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.381549 | 0.418 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.381549 | 0.418 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.382586 | 0.417 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.382586 | 0.417 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.388594 | 0.411 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.388594 | 0.411 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.388594 | 0.411 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.388594 | 0.411 |
| R-HSA-8853659 | RET signaling | 0.388594 | 0.411 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.388594 | 0.411 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.394657 | 0.404 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.394657 | 0.404 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.395559 | 0.403 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.395559 | 0.403 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.395559 | 0.403 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.395559 | 0.403 |
| R-HSA-2559583 | Cellular Senescence | 0.397470 | 0.401 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.398657 | 0.399 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.402445 | 0.395 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.405427 | 0.392 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.406633 | 0.391 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.409254 | 0.388 |
| R-HSA-69275 | G2/M Transition | 0.415755 | 0.381 |
| R-HSA-9646399 | Aggrephagy | 0.415985 | 0.381 |
| R-HSA-202433 | Generation of second messenger molecules | 0.415985 | 0.381 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.415985 | 0.381 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.418209 | 0.379 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.421812 | 0.375 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.422639 | 0.374 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.422639 | 0.374 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.435724 | 0.361 |
| R-HSA-68877 | Mitotic Prometaphase | 0.436862 | 0.360 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.441804 | 0.355 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.442155 | 0.354 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.442155 | 0.354 |
| R-HSA-446728 | Cell junction organization | 0.443578 | 0.353 |
| R-HSA-2172127 | DAP12 interactions | 0.448513 | 0.348 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.448513 | 0.348 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.448513 | 0.348 |
| R-HSA-68875 | Mitotic Prophase | 0.453278 | 0.344 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.453637 | 0.343 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.454799 | 0.342 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.457073 | 0.340 |
| R-HSA-3371556 | Cellular response to heat stress | 0.457073 | 0.340 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.461014 | 0.336 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.461014 | 0.336 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.463749 | 0.334 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.464618 | 0.333 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.466506 | 0.331 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.473232 | 0.325 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.473232 | 0.325 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.473232 | 0.325 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.475819 | 0.323 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.475819 | 0.323 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.475819 | 0.323 |
| R-HSA-69206 | G1/S Transition | 0.475819 | 0.323 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.479238 | 0.319 |
| R-HSA-9766229 | Degradation of CDH1 | 0.479238 | 0.319 |
| R-HSA-73893 | DNA Damage Bypass | 0.479238 | 0.319 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.479238 | 0.319 |
| R-HSA-69481 | G2/M Checkpoints | 0.483207 | 0.316 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.485176 | 0.314 |
| R-HSA-9679506 | SARS-CoV Infections | 0.487945 | 0.312 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.491046 | 0.309 |
| R-HSA-9864848 | Complex IV assembly | 0.491046 | 0.309 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.496850 | 0.304 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.496850 | 0.304 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.502588 | 0.299 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.502588 | 0.299 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.502588 | 0.299 |
| R-HSA-1221632 | Meiotic synapsis | 0.502588 | 0.299 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.502588 | 0.299 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513869 | 0.289 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.513869 | 0.289 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.519414 | 0.284 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.519414 | 0.284 |
| R-HSA-5578775 | Ion homeostasis | 0.519414 | 0.284 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.524896 | 0.280 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.524896 | 0.280 |
| R-HSA-1483166 | Synthesis of PA | 0.524896 | 0.280 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.524896 | 0.280 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.526162 | 0.279 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.530316 | 0.275 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.530316 | 0.275 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.535674 | 0.271 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.535674 | 0.271 |
| R-HSA-191859 | snRNP Assembly | 0.535674 | 0.271 |
| R-HSA-1500931 | Cell-Cell communication | 0.536315 | 0.271 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.540972 | 0.267 |
| R-HSA-379724 | tRNA Aminoacylation | 0.540972 | 0.267 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.546209 | 0.263 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.551387 | 0.259 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.551387 | 0.259 |
| R-HSA-1268020 | Mitochondrial protein import | 0.551387 | 0.259 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.551387 | 0.259 |
| R-HSA-9824446 | Viral Infection Pathways | 0.554288 | 0.256 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.556506 | 0.255 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.556506 | 0.255 |
| R-HSA-8848021 | Signaling by PTK6 | 0.556506 | 0.255 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.556506 | 0.255 |
| R-HSA-373755 | Semaphorin interactions | 0.556506 | 0.255 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.560086 | 0.252 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.566571 | 0.247 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.571518 | 0.243 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.571518 | 0.243 |
| R-HSA-157118 | Signaling by NOTCH | 0.572041 | 0.243 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.576390 | 0.239 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.576408 | 0.239 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.581243 | 0.236 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.581243 | 0.236 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.590750 | 0.229 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.595422 | 0.225 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.595422 | 0.225 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.595422 | 0.225 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.595422 | 0.225 |
| R-HSA-1640170 | Cell Cycle | 0.596180 | 0.225 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.600041 | 0.222 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.600041 | 0.222 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.600041 | 0.222 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.600041 | 0.222 |
| R-HSA-877300 | Interferon gamma signaling | 0.601557 | 0.221 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.604608 | 0.219 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.604608 | 0.219 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.609123 | 0.215 |
| R-HSA-5688426 | Deubiquitination | 0.610016 | 0.215 |
| R-HSA-380287 | Centrosome maturation | 0.613587 | 0.212 |
| R-HSA-8852135 | Protein ubiquitination | 0.613587 | 0.212 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.613587 | 0.212 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.613587 | 0.212 |
| R-HSA-917937 | Iron uptake and transport | 0.613587 | 0.212 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.617339 | 0.209 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.617999 | 0.209 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.622362 | 0.206 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.635156 | 0.197 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.635156 | 0.197 |
| R-HSA-9833482 | PKR-mediated signaling | 0.635156 | 0.197 |
| R-HSA-6806834 | Signaling by MET | 0.635156 | 0.197 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.639324 | 0.194 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.639324 | 0.194 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.640031 | 0.194 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.643444 | 0.191 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.651270 | 0.186 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.655527 | 0.183 |
| R-HSA-1500620 | Meiosis | 0.655527 | 0.183 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.659463 | 0.181 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.659463 | 0.181 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.664753 | 0.177 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.665976 | 0.177 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.667203 | 0.176 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.671006 | 0.173 |
| R-HSA-68886 | M Phase | 0.678397 | 0.169 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.678484 | 0.168 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.680272 | 0.167 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.682160 | 0.166 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.682160 | 0.166 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.687513 | 0.163 |
| R-HSA-983712 | Ion channel transport | 0.688425 | 0.162 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.689386 | 0.162 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.692937 | 0.159 |
| R-HSA-1474290 | Collagen formation | 0.696449 | 0.157 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.700889 | 0.154 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.701964 | 0.154 |
| R-HSA-195721 | Signaling by WNT | 0.705999 | 0.151 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.706744 | 0.151 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.713414 | 0.147 |
| R-HSA-190236 | Signaling by FGFR | 0.713414 | 0.147 |
| R-HSA-3214847 | HATs acetylate histones | 0.716692 | 0.145 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.716692 | 0.145 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.719933 | 0.143 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.723137 | 0.141 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.726305 | 0.139 |
| R-HSA-72172 | mRNA Splicing | 0.726861 | 0.139 |
| R-HSA-9833110 | RSV-host interactions | 0.735593 | 0.133 |
| R-HSA-418346 | Platelet homeostasis | 0.741610 | 0.130 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.741610 | 0.130 |
| R-HSA-397014 | Muscle contraction | 0.744536 | 0.128 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.747670 | 0.126 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.750381 | 0.125 |
| R-HSA-68882 | Mitotic Anaphase | 0.753003 | 0.123 |
| R-HSA-202403 | TCR signaling | 0.753239 | 0.123 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.755082 | 0.122 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.758856 | 0.120 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.761617 | 0.118 |
| R-HSA-8951664 | Neddylation | 0.763248 | 0.117 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.764347 | 0.117 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.767045 | 0.115 |
| R-HSA-373760 | L1CAM interactions | 0.774957 | 0.111 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.776973 | 0.110 |
| R-HSA-5693538 | Homology Directed Repair | 0.780083 | 0.108 |
| R-HSA-1280218 | Adaptive Immune System | 0.783067 | 0.106 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.787555 | 0.104 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.792248 | 0.101 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.794774 | 0.100 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.795275 | 0.099 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.806268 | 0.094 |
| R-HSA-1474165 | Reproduction | 0.812855 | 0.090 |
| R-HSA-5576891 | Cardiac conduction | 0.815000 | 0.089 |
| R-HSA-9675108 | Nervous system development | 0.821995 | 0.085 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.825160 | 0.083 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.831307 | 0.080 |
| R-HSA-9664407 | Parasite infection | 0.835156 | 0.078 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.835156 | 0.078 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.835156 | 0.078 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.837047 | 0.077 |
| R-HSA-913531 | Interferon Signaling | 0.842570 | 0.074 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.849695 | 0.071 |
| R-HSA-69242 | S Phase | 0.851420 | 0.070 |
| R-HSA-166520 | Signaling by NTRKs | 0.851420 | 0.070 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.859756 | 0.066 |
| R-HSA-9609507 | Protein localization | 0.859756 | 0.066 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.861366 | 0.065 |
| R-HSA-1989781 | PPARA activates gene expression | 0.862958 | 0.064 |
| R-HSA-9610379 | HCMV Late Events | 0.866088 | 0.062 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.866088 | 0.062 |
| R-HSA-162587 | HIV Life Cycle | 0.866088 | 0.062 |
| R-HSA-597592 | Post-translational protein modification | 0.873788 | 0.059 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.876493 | 0.057 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.876493 | 0.057 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.888697 | 0.051 |
| R-HSA-422475 | Axon guidance | 0.890185 | 0.051 |
| R-HSA-5663205 | Infectious disease | 0.890482 | 0.050 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.891242 | 0.050 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.892492 | 0.049 |
| R-HSA-611105 | Respiratory electron transport | 0.896159 | 0.048 |
| R-HSA-5617833 | Cilium Assembly | 0.909622 | 0.041 |
| R-HSA-1474244 | Extracellular matrix organization | 0.911592 | 0.040 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.919505 | 0.036 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.921349 | 0.036 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.922255 | 0.035 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.922255 | 0.035 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.930763 | 0.031 |
| R-HSA-73894 | DNA Repair | 0.932730 | 0.030 |
| R-HSA-162906 | HIV Infection | 0.941819 | 0.026 |
| R-HSA-388396 | GPCR downstream signalling | 0.951840 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.953289 | 0.021 |
| R-HSA-416476 | G alpha (q) signalling events | 0.962148 | 0.017 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.966305 | 0.015 |
| R-HSA-9658195 | Leishmania infection | 0.968942 | 0.014 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.968942 | 0.014 |
| R-HSA-8953854 | Metabolism of RNA | 0.969603 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 0.973616 | 0.012 |
| R-HSA-372790 | Signaling by GPCR | 0.974367 | 0.011 |
| R-HSA-112316 | Neuronal System | 0.976780 | 0.010 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.980968 | 0.008 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.984577 | 0.007 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.987619 | 0.005 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.991411 | 0.004 |
| R-HSA-1643685 | Disease | 0.992918 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994100 | 0.003 |
| R-HSA-72766 | Translation | 0.994566 | 0.002 |
| R-HSA-109582 | Hemostasis | 0.995428 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 0.996456 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.997166 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999419 | 0.000 |
| R-HSA-449147 | Signaling by Interleukins | 0.999465 | 0.000 |
| R-HSA-168256 | Immune System | 0.999731 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999905 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999995 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | -0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
KIS |
0.867 | 0.775 | 1 | 0.891 |
HIPK2 |
0.861 | 0.759 | 1 | 0.923 |
CDK18 |
0.848 | 0.758 | 1 | 0.917 |
CDK19 |
0.847 | 0.751 | 1 | 0.897 |
DYRK2 |
0.846 | 0.727 | 1 | 0.895 |
CLK3 |
0.845 | 0.535 | 1 | 0.755 |
HIPK4 |
0.843 | 0.593 | 1 | 0.777 |
CDK8 |
0.841 | 0.736 | 1 | 0.888 |
DYRK4 |
0.841 | 0.724 | 1 | 0.929 |
P38G |
0.840 | 0.754 | 1 | 0.915 |
CDK17 |
0.840 | 0.746 | 1 | 0.914 |
P38B |
0.839 | 0.766 | 1 | 0.913 |
ERK1 |
0.839 | 0.747 | 1 | 0.909 |
P38D |
0.838 | 0.768 | 1 | 0.925 |
HIPK1 |
0.838 | 0.677 | 1 | 0.879 |
CDK1 |
0.837 | 0.698 | 1 | 0.917 |
JNK2 |
0.837 | 0.755 | 1 | 0.899 |
CDK7 |
0.836 | 0.710 | 1 | 0.906 |
CDK16 |
0.833 | 0.720 | 1 | 0.913 |
JNK3 |
0.830 | 0.734 | 1 | 0.903 |
CDK3 |
0.829 | 0.618 | 1 | 0.922 |
P38A |
0.829 | 0.735 | 1 | 0.888 |
CDK13 |
0.828 | 0.692 | 1 | 0.906 |
DYRK1B |
0.828 | 0.670 | 1 | 0.901 |
CDK5 |
0.826 | 0.665 | 1 | 0.901 |
CLK2 |
0.825 | 0.435 | -3 | 0.749 |
SRPK1 |
0.825 | 0.356 | -3 | 0.748 |
CDK12 |
0.825 | 0.692 | 1 | 0.906 |
CDK14 |
0.824 | 0.708 | 1 | 0.888 |
CDK10 |
0.824 | 0.667 | 1 | 0.899 |
DYRK1A |
0.823 | 0.592 | 1 | 0.858 |
ERK5 |
0.820 | 0.427 | 1 | 0.725 |
NLK |
0.819 | 0.629 | 1 | 0.745 |
HIPK3 |
0.819 | 0.645 | 1 | 0.835 |
CDK9 |
0.819 | 0.679 | 1 | 0.898 |
ERK2 |
0.819 | 0.701 | 1 | 0.892 |
MAK |
0.815 | 0.541 | -2 | 0.814 |
JNK1 |
0.814 | 0.660 | 1 | 0.903 |
CDKL5 |
0.813 | 0.260 | -3 | 0.774 |
DYRK3 |
0.812 | 0.520 | 1 | 0.853 |
SRPK2 |
0.812 | 0.285 | -3 | 0.677 |
CLK4 |
0.811 | 0.382 | -3 | 0.753 |
ICK |
0.810 | 0.407 | -3 | 0.813 |
CLK1 |
0.809 | 0.400 | -3 | 0.728 |
COT |
0.808 | 0.001 | 2 | 0.814 |
MOS |
0.807 | 0.129 | 1 | 0.522 |
CDKL1 |
0.806 | 0.216 | -3 | 0.779 |
MTOR |
0.804 | 0.209 | 1 | 0.542 |
NDR2 |
0.803 | 0.080 | -3 | 0.833 |
CDC7 |
0.801 | -0.017 | 1 | 0.473 |
SRPK3 |
0.801 | 0.246 | -3 | 0.712 |
CDK4 |
0.800 | 0.663 | 1 | 0.911 |
PIM3 |
0.800 | 0.045 | -3 | 0.828 |
MOK |
0.800 | 0.487 | 1 | 0.837 |
CDK6 |
0.798 | 0.637 | 1 | 0.890 |
GRK1 |
0.796 | 0.093 | -2 | 0.774 |
CDK2 |
0.796 | 0.470 | 1 | 0.846 |
PRKD1 |
0.796 | 0.112 | -3 | 0.803 |
PRPK |
0.793 | -0.028 | -1 | 0.773 |
ATR |
0.793 | 0.023 | 1 | 0.502 |
PRP4 |
0.793 | 0.435 | -3 | 0.720 |
RSK2 |
0.792 | 0.062 | -3 | 0.762 |
PRKD2 |
0.792 | 0.099 | -3 | 0.768 |
SKMLCK |
0.791 | 0.022 | -2 | 0.812 |
PIM1 |
0.790 | 0.074 | -3 | 0.786 |
GSK3A |
0.789 | 0.269 | 4 | 0.604 |
AURC |
0.788 | 0.064 | -2 | 0.609 |
GRK7 |
0.788 | 0.091 | 1 | 0.437 |
ERK7 |
0.787 | 0.288 | 2 | 0.606 |
NDR1 |
0.787 | -0.007 | -3 | 0.818 |
BMPR1B |
0.787 | 0.049 | 1 | 0.436 |
P90RSK |
0.787 | 0.052 | -3 | 0.762 |
CAMK1B |
0.786 | -0.010 | -3 | 0.815 |
CHAK2 |
0.786 | -0.010 | -1 | 0.750 |
MAPKAPK2 |
0.785 | 0.048 | -3 | 0.748 |
GCN2 |
0.784 | -0.126 | 2 | 0.736 |
IKKB |
0.784 | -0.123 | -2 | 0.660 |
PKN3 |
0.784 | -0.010 | -3 | 0.793 |
TBK1 |
0.783 | -0.121 | 1 | 0.319 |
RAF1 |
0.783 | -0.160 | 1 | 0.415 |
NUAK2 |
0.783 | 0.014 | -3 | 0.815 |
PDHK4 |
0.783 | -0.161 | 1 | 0.480 |
LATS1 |
0.783 | 0.097 | -3 | 0.845 |
BMPR2 |
0.783 | -0.113 | -2 | 0.815 |
DSTYK |
0.783 | -0.115 | 2 | 0.856 |
CAMLCK |
0.782 | 0.013 | -2 | 0.779 |
GRK5 |
0.782 | -0.081 | -3 | 0.798 |
PKACB |
0.782 | 0.067 | -2 | 0.612 |
NEK6 |
0.781 | -0.060 | -2 | 0.787 |
NIK |
0.781 | -0.026 | -3 | 0.825 |
LATS2 |
0.781 | -0.002 | -5 | 0.750 |
MST4 |
0.780 | -0.034 | 2 | 0.849 |
IKKE |
0.779 | -0.143 | 1 | 0.317 |
WNK1 |
0.779 | -0.063 | -2 | 0.822 |
MLK3 |
0.779 | 0.004 | 2 | 0.743 |
RSK4 |
0.779 | 0.059 | -3 | 0.745 |
TGFBR2 |
0.779 | -0.051 | -2 | 0.767 |
PRKX |
0.779 | 0.076 | -3 | 0.705 |
CAMK2G |
0.779 | -0.101 | 2 | 0.725 |
RSK3 |
0.779 | 0.013 | -3 | 0.749 |
MLK1 |
0.779 | -0.099 | 2 | 0.796 |
DAPK2 |
0.778 | -0.011 | -3 | 0.816 |
PKCD |
0.778 | 0.001 | 2 | 0.764 |
MAPKAPK3 |
0.778 | 0.011 | -3 | 0.770 |
RIPK3 |
0.778 | -0.131 | 3 | 0.678 |
P70S6KB |
0.778 | 0.013 | -3 | 0.772 |
FAM20C |
0.778 | 0.036 | 2 | 0.620 |
PKACG |
0.777 | -0.005 | -2 | 0.673 |
IKKA |
0.777 | -0.050 | -2 | 0.663 |
MLK2 |
0.777 | -0.040 | 2 | 0.792 |
PKN2 |
0.776 | -0.048 | -3 | 0.803 |
TGFBR1 |
0.774 | 0.015 | -2 | 0.787 |
PDHK1 |
0.773 | -0.201 | 1 | 0.445 |
PKCB |
0.773 | 0.004 | 2 | 0.738 |
ALK4 |
0.773 | -0.002 | -2 | 0.805 |
CAMK2D |
0.773 | -0.055 | -3 | 0.795 |
CAMK2A |
0.772 | 0.018 | 2 | 0.714 |
GRK6 |
0.772 | -0.099 | 1 | 0.432 |
CAMK2B |
0.772 | -0.012 | 2 | 0.709 |
PAK1 |
0.772 | -0.024 | -2 | 0.729 |
ULK2 |
0.772 | -0.240 | 2 | 0.724 |
MPSK1 |
0.772 | 0.133 | 1 | 0.502 |
NEK7 |
0.771 | -0.193 | -3 | 0.768 |
AMPKA1 |
0.771 | -0.080 | -3 | 0.825 |
MARK4 |
0.771 | -0.104 | 4 | 0.762 |
PRKD3 |
0.771 | 0.038 | -3 | 0.724 |
ATM |
0.771 | -0.056 | 1 | 0.451 |
DLK |
0.770 | -0.143 | 1 | 0.431 |
PKCA |
0.770 | 0.016 | 2 | 0.732 |
HUNK |
0.770 | -0.183 | 2 | 0.734 |
GRK4 |
0.770 | -0.108 | -2 | 0.786 |
GSK3B |
0.769 | 0.130 | 4 | 0.597 |
AMPKA2 |
0.769 | -0.046 | -3 | 0.802 |
IRE1 |
0.769 | -0.097 | 1 | 0.456 |
PKCG |
0.769 | -0.016 | 2 | 0.730 |
MSK1 |
0.769 | 0.019 | -3 | 0.745 |
MSK2 |
0.769 | -0.013 | -3 | 0.739 |
MASTL |
0.768 | -0.181 | -2 | 0.742 |
AKT2 |
0.768 | 0.052 | -3 | 0.688 |
PKR |
0.768 | -0.048 | 1 | 0.477 |
PASK |
0.768 | 0.069 | -3 | 0.834 |
PIM2 |
0.768 | 0.057 | -3 | 0.733 |
CK1E |
0.767 | 0.030 | -3 | 0.545 |
MNK1 |
0.767 | -0.010 | -2 | 0.721 |
PHKG1 |
0.767 | -0.034 | -3 | 0.800 |
ALK2 |
0.767 | -0.007 | -2 | 0.794 |
AURB |
0.766 | -0.000 | -2 | 0.600 |
SMG1 |
0.766 | -0.036 | 1 | 0.475 |
BCKDK |
0.766 | -0.178 | -1 | 0.684 |
ACVR2B |
0.766 | -0.033 | -2 | 0.757 |
BMPR1A |
0.765 | 0.005 | 1 | 0.411 |
PKCZ |
0.765 | -0.031 | 2 | 0.764 |
TLK2 |
0.765 | -0.052 | 1 | 0.435 |
MLK4 |
0.765 | -0.072 | 2 | 0.715 |
DNAPK |
0.765 | -0.019 | 1 | 0.400 |
PKG2 |
0.765 | 0.002 | -2 | 0.612 |
NEK9 |
0.765 | -0.180 | 2 | 0.798 |
VRK2 |
0.765 | -0.002 | 1 | 0.535 |
PAK3 |
0.765 | -0.065 | -2 | 0.712 |
ANKRD3 |
0.764 | -0.185 | 1 | 0.443 |
MNK2 |
0.764 | -0.042 | -2 | 0.716 |
ACVR2A |
0.764 | -0.044 | -2 | 0.745 |
BUB1 |
0.764 | 0.191 | -5 | 0.821 |
TSSK1 |
0.764 | -0.068 | -3 | 0.838 |
NIM1 |
0.764 | -0.114 | 3 | 0.712 |
RIPK1 |
0.763 | -0.213 | 1 | 0.422 |
SGK3 |
0.763 | 0.008 | -3 | 0.759 |
TTBK2 |
0.762 | -0.183 | 2 | 0.647 |
TSSK2 |
0.762 | -0.111 | -5 | 0.838 |
CK1D |
0.762 | 0.057 | -3 | 0.501 |
ULK1 |
0.762 | -0.225 | -3 | 0.738 |
IRE2 |
0.762 | -0.101 | 2 | 0.705 |
YSK4 |
0.761 | -0.111 | 1 | 0.367 |
WNK3 |
0.761 | -0.262 | 1 | 0.419 |
GRK2 |
0.761 | -0.057 | -2 | 0.683 |
MYLK4 |
0.761 | -0.029 | -2 | 0.702 |
PAK6 |
0.761 | -0.002 | -2 | 0.629 |
NUAK1 |
0.761 | -0.058 | -3 | 0.769 |
QSK |
0.760 | -0.066 | 4 | 0.733 |
PKCH |
0.760 | -0.049 | 2 | 0.710 |
CAMK4 |
0.760 | -0.117 | -3 | 0.784 |
PINK1 |
0.759 | 0.084 | 1 | 0.640 |
PKACA |
0.759 | 0.032 | -2 | 0.566 |
PAK2 |
0.759 | -0.070 | -2 | 0.709 |
AURA |
0.758 | -0.016 | -2 | 0.578 |
MST3 |
0.758 | -0.011 | 2 | 0.831 |
MELK |
0.757 | -0.094 | -3 | 0.777 |
MEK1 |
0.757 | -0.161 | 2 | 0.772 |
PLK1 |
0.757 | -0.163 | -2 | 0.722 |
CHAK1 |
0.756 | -0.159 | 2 | 0.742 |
DCAMKL1 |
0.756 | -0.038 | -3 | 0.778 |
SIK |
0.756 | -0.066 | -3 | 0.740 |
BRSK1 |
0.754 | -0.086 | -3 | 0.769 |
CK1A2 |
0.754 | 0.018 | -3 | 0.502 |
MAPKAPK5 |
0.753 | -0.061 | -3 | 0.696 |
QIK |
0.753 | -0.148 | -3 | 0.780 |
PERK |
0.753 | -0.106 | -2 | 0.782 |
TAO3 |
0.753 | -0.020 | 1 | 0.425 |
CHK1 |
0.753 | -0.049 | -3 | 0.806 |
DRAK1 |
0.753 | -0.128 | 1 | 0.384 |
CAMK1G |
0.753 | -0.058 | -3 | 0.729 |
AKT1 |
0.752 | 0.018 | -3 | 0.709 |
NEK2 |
0.752 | -0.148 | 2 | 0.791 |
CK1G1 |
0.752 | -0.027 | -3 | 0.548 |
TLK1 |
0.751 | -0.117 | -2 | 0.785 |
GRK3 |
0.751 | -0.051 | -2 | 0.657 |
GAK |
0.750 | -0.009 | 1 | 0.491 |
MEK5 |
0.750 | -0.176 | 2 | 0.770 |
MEKK2 |
0.750 | -0.131 | 2 | 0.756 |
CK2A2 |
0.750 | -0.037 | 1 | 0.404 |
BRSK2 |
0.749 | -0.122 | -3 | 0.780 |
NEK5 |
0.749 | -0.131 | 1 | 0.438 |
MARK3 |
0.749 | -0.098 | 4 | 0.680 |
WNK4 |
0.749 | -0.128 | -2 | 0.819 |
MEKK1 |
0.748 | -0.164 | 1 | 0.408 |
MEKK3 |
0.748 | -0.176 | 1 | 0.407 |
DAPK3 |
0.748 | -0.014 | -3 | 0.782 |
PKCT |
0.748 | -0.055 | 2 | 0.718 |
SGK1 |
0.747 | 0.056 | -3 | 0.631 |
PLK3 |
0.747 | -0.158 | 2 | 0.676 |
PKCE |
0.747 | 0.008 | 2 | 0.724 |
SMMLCK |
0.747 | -0.044 | -3 | 0.775 |
P70S6K |
0.746 | -0.020 | -3 | 0.690 |
AKT3 |
0.746 | 0.039 | -3 | 0.649 |
ZAK |
0.746 | -0.175 | 1 | 0.376 |
LKB1 |
0.745 | -0.026 | -3 | 0.762 |
SBK |
0.745 | 0.128 | -3 | 0.590 |
BRAF |
0.744 | -0.175 | -4 | 0.816 |
ROCK2 |
0.744 | 0.033 | -3 | 0.780 |
PKCI |
0.744 | -0.039 | 2 | 0.743 |
MARK2 |
0.744 | -0.126 | 4 | 0.642 |
GCK |
0.743 | -0.032 | 1 | 0.405 |
PAK5 |
0.743 | -0.038 | -2 | 0.583 |
PLK4 |
0.743 | -0.184 | 2 | 0.549 |
IRAK4 |
0.743 | -0.173 | 1 | 0.423 |
CAMK1D |
0.743 | -0.027 | -3 | 0.684 |
HRI |
0.742 | -0.202 | -2 | 0.779 |
CK2A1 |
0.742 | -0.036 | 1 | 0.388 |
DAPK1 |
0.742 | -0.018 | -3 | 0.761 |
DCAMKL2 |
0.742 | -0.081 | -3 | 0.782 |
SSTK |
0.742 | -0.099 | 4 | 0.729 |
PAK4 |
0.742 | -0.028 | -2 | 0.593 |
SNRK |
0.742 | -0.209 | 2 | 0.612 |
NEK8 |
0.740 | -0.158 | 2 | 0.781 |
PDK1 |
0.740 | -0.080 | 1 | 0.427 |
MRCKB |
0.739 | 0.011 | -3 | 0.722 |
NEK11 |
0.739 | -0.151 | 1 | 0.401 |
TAO2 |
0.739 | -0.086 | 2 | 0.814 |
MARK1 |
0.738 | -0.146 | 4 | 0.704 |
TNIK |
0.738 | -0.041 | 3 | 0.755 |
PHKG2 |
0.738 | -0.103 | -3 | 0.755 |
MRCKA |
0.737 | 0.002 | -3 | 0.742 |
MEKK6 |
0.737 | -0.098 | 1 | 0.425 |
CAMKK2 |
0.737 | -0.123 | -2 | 0.673 |
MAP3K15 |
0.736 | -0.086 | 1 | 0.378 |
HASPIN |
0.736 | 0.029 | -1 | 0.644 |
HPK1 |
0.736 | -0.059 | 1 | 0.390 |
LRRK2 |
0.736 | -0.056 | 2 | 0.803 |
MST2 |
0.735 | -0.122 | 1 | 0.395 |
CHK2 |
0.735 | -0.003 | -3 | 0.640 |
PDHK3_TYR |
0.734 | 0.216 | 4 | 0.883 |
HGK |
0.734 | -0.088 | 3 | 0.754 |
EEF2K |
0.734 | -0.101 | 3 | 0.677 |
DMPK1 |
0.734 | 0.040 | -3 | 0.749 |
SLK |
0.734 | -0.039 | -2 | 0.635 |
CAMKK1 |
0.734 | -0.200 | -2 | 0.670 |
PBK |
0.734 | -0.017 | 1 | 0.451 |
LOK |
0.734 | -0.053 | -2 | 0.674 |
KHS1 |
0.733 | -0.036 | 1 | 0.385 |
PKN1 |
0.733 | -0.037 | -3 | 0.704 |
KHS2 |
0.733 | -0.024 | 1 | 0.401 |
CRIK |
0.732 | 0.045 | -3 | 0.720 |
TAK1 |
0.732 | -0.145 | 1 | 0.415 |
PDHK4_TYR |
0.731 | 0.162 | 2 | 0.806 |
MINK |
0.731 | -0.131 | 1 | 0.380 |
NEK4 |
0.731 | -0.173 | 1 | 0.389 |
CAMK1A |
0.730 | -0.018 | -3 | 0.661 |
VRK1 |
0.730 | -0.175 | 2 | 0.778 |
CK1A |
0.729 | 0.012 | -3 | 0.425 |
PLK2 |
0.729 | -0.092 | -3 | 0.700 |
TTBK1 |
0.728 | -0.205 | 2 | 0.553 |
NEK1 |
0.727 | -0.154 | 1 | 0.402 |
TESK1_TYR |
0.726 | 0.098 | 3 | 0.803 |
ROCK1 |
0.726 | 0.002 | -3 | 0.739 |
MAP2K6_TYR |
0.725 | 0.100 | -1 | 0.789 |
MST1 |
0.725 | -0.137 | 1 | 0.382 |
OSR1 |
0.725 | -0.050 | 2 | 0.766 |
LIMK2_TYR |
0.725 | 0.158 | -3 | 0.832 |
MAP2K4_TYR |
0.724 | 0.099 | -1 | 0.788 |
YSK1 |
0.723 | -0.117 | 2 | 0.794 |
TTK |
0.723 | -0.082 | -2 | 0.768 |
PKMYT1_TYR |
0.723 | 0.125 | 3 | 0.792 |
PDHK1_TYR |
0.722 | 0.035 | -1 | 0.802 |
BMPR2_TYR |
0.721 | 0.051 | -1 | 0.796 |
PKG1 |
0.719 | -0.045 | -2 | 0.535 |
STK33 |
0.719 | -0.178 | 2 | 0.548 |
IRAK1 |
0.718 | -0.322 | -1 | 0.634 |
ALPHAK3 |
0.717 | -0.065 | -1 | 0.685 |
MAP2K7_TYR |
0.717 | -0.069 | 2 | 0.788 |
BIKE |
0.716 | -0.042 | 1 | 0.429 |
ABL2 |
0.715 | 0.044 | -1 | 0.725 |
PINK1_TYR |
0.714 | -0.108 | 1 | 0.492 |
MYO3B |
0.714 | -0.068 | 2 | 0.807 |
YANK3 |
0.714 | -0.067 | 2 | 0.344 |
MEK2 |
0.712 | -0.267 | 2 | 0.746 |
TXK |
0.711 | 0.006 | 1 | 0.435 |
AAK1 |
0.711 | 0.010 | 1 | 0.400 |
RET |
0.711 | -0.082 | 1 | 0.429 |
ABL1 |
0.710 | 0.025 | -1 | 0.716 |
NEK3 |
0.710 | -0.167 | 1 | 0.384 |
RIPK2 |
0.710 | -0.286 | 1 | 0.334 |
ASK1 |
0.710 | -0.143 | 1 | 0.367 |
EPHB4 |
0.709 | -0.038 | -1 | 0.737 |
EPHA6 |
0.709 | -0.062 | -1 | 0.778 |
LIMK1_TYR |
0.708 | -0.048 | 2 | 0.797 |
FGR |
0.708 | -0.076 | 1 | 0.450 |
CSF1R |
0.707 | -0.051 | 3 | 0.753 |
MST1R |
0.707 | -0.079 | 3 | 0.773 |
TAO1 |
0.706 | -0.107 | 1 | 0.353 |
TNK2 |
0.706 | -0.041 | 3 | 0.718 |
MYO3A |
0.706 | -0.124 | 1 | 0.405 |
YES1 |
0.706 | -0.072 | -1 | 0.777 |
JAK2 |
0.705 | -0.087 | 1 | 0.423 |
LCK |
0.704 | -0.029 | -1 | 0.771 |
BLK |
0.703 | -0.030 | -1 | 0.778 |
ROS1 |
0.702 | -0.140 | 3 | 0.709 |
TYRO3 |
0.702 | -0.139 | 3 | 0.744 |
INSRR |
0.702 | -0.120 | 3 | 0.696 |
TYK2 |
0.700 | -0.213 | 1 | 0.413 |
FGFR2 |
0.700 | -0.073 | 3 | 0.750 |
KDR |
0.700 | -0.075 | 3 | 0.714 |
EPHA4 |
0.700 | -0.051 | 2 | 0.691 |
JAK3 |
0.700 | -0.128 | 1 | 0.417 |
DDR1 |
0.700 | -0.155 | 4 | 0.794 |
MET |
0.699 | -0.049 | 3 | 0.765 |
FYN |
0.699 | -0.022 | -1 | 0.768 |
TNK1 |
0.699 | -0.052 | 3 | 0.743 |
FER |
0.699 | -0.155 | 1 | 0.463 |
HCK |
0.699 | -0.101 | -1 | 0.764 |
CK1G3 |
0.698 | -0.018 | -3 | 0.384 |
KIT |
0.698 | -0.099 | 3 | 0.754 |
SRMS |
0.697 | -0.121 | 1 | 0.430 |
ITK |
0.696 | -0.099 | -1 | 0.713 |
EPHB1 |
0.695 | -0.128 | 1 | 0.424 |
DDR2 |
0.695 | -0.025 | 3 | 0.680 |
NEK10_TYR |
0.695 | -0.097 | 1 | 0.351 |
MERTK |
0.694 | -0.103 | 3 | 0.759 |
BMX |
0.694 | -0.081 | -1 | 0.664 |
JAK1 |
0.694 | -0.089 | 1 | 0.357 |
EPHB3 |
0.694 | -0.112 | -1 | 0.720 |
EPHB2 |
0.692 | -0.108 | -1 | 0.715 |
FLT1 |
0.692 | -0.093 | -1 | 0.737 |
FGFR1 |
0.692 | -0.103 | 3 | 0.727 |
TEK |
0.691 | -0.079 | 3 | 0.690 |
STLK3 |
0.691 | -0.218 | 1 | 0.350 |
TNNI3K_TYR |
0.691 | -0.073 | 1 | 0.460 |
FLT3 |
0.691 | -0.168 | 3 | 0.741 |
CK1G2 |
0.691 | -0.006 | -3 | 0.468 |
FGFR3 |
0.691 | -0.086 | 3 | 0.724 |
PDGFRB |
0.690 | -0.202 | 3 | 0.744 |
PTK2 |
0.690 | 0.003 | -1 | 0.735 |
TEC |
0.690 | -0.111 | -1 | 0.662 |
SYK |
0.688 | 0.006 | -1 | 0.719 |
EPHA7 |
0.688 | -0.105 | 2 | 0.692 |
AXL |
0.687 | -0.168 | 3 | 0.747 |
PTK2B |
0.686 | -0.044 | -1 | 0.684 |
LTK |
0.686 | -0.159 | 3 | 0.704 |
ALK |
0.685 | -0.170 | 3 | 0.673 |
FRK |
0.685 | -0.122 | -1 | 0.771 |
EPHA3 |
0.684 | -0.121 | 2 | 0.662 |
WEE1_TYR |
0.684 | -0.116 | -1 | 0.650 |
LYN |
0.684 | -0.111 | 3 | 0.677 |
SRC |
0.684 | -0.096 | -1 | 0.755 |
ERBB2 |
0.684 | -0.161 | 1 | 0.382 |
PDGFRA |
0.683 | -0.217 | 3 | 0.739 |
EPHA5 |
0.682 | -0.098 | 2 | 0.674 |
MATK |
0.682 | -0.105 | -1 | 0.649 |
NTRK1 |
0.682 | -0.210 | -1 | 0.716 |
EPHA1 |
0.682 | -0.131 | 3 | 0.749 |
EPHA8 |
0.682 | -0.089 | -1 | 0.723 |
EGFR |
0.681 | -0.100 | 1 | 0.323 |
NTRK3 |
0.681 | -0.142 | -1 | 0.677 |
ZAP70 |
0.681 | 0.025 | -1 | 0.645 |
PTK6 |
0.680 | -0.206 | -1 | 0.629 |
YANK2 |
0.680 | -0.089 | 2 | 0.357 |
FLT4 |
0.680 | -0.181 | 3 | 0.706 |
BTK |
0.680 | -0.220 | -1 | 0.686 |
INSR |
0.679 | -0.182 | 3 | 0.682 |
FGFR4 |
0.677 | -0.104 | -1 | 0.671 |
ERBB4 |
0.676 | -0.067 | 1 | 0.342 |
NTRK2 |
0.675 | -0.233 | 3 | 0.709 |
CSK |
0.674 | -0.146 | 2 | 0.688 |
EPHA2 |
0.674 | -0.090 | -1 | 0.692 |
IGF1R |
0.668 | -0.159 | 3 | 0.637 |
MUSK |
0.666 | -0.149 | 1 | 0.322 |
FES |
0.651 | -0.172 | -1 | 0.629 |