Motif 223 (n=169)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S1011 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NCI8 | C2orf78 | S819 | ochoa | Uncharacterized protein C2orf78 | None |
| B1AK53 | ESPN | S700 | ochoa | Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) | Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:29572253). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia (PubMed:29572253). In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. {ECO:0000250|UniProtKB:Q9ET47, ECO:0000269|PubMed:29572253}. |
| E9PAV3 | NACA | S874 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1304 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1388 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1623 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| H0YIS7 | RNASEK-C17orf49 | S151 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O14526 | FCHO1 | S501 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14654 | IRS4 | S409 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14686 | KMT2D | S1180 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15014 | ZNF609 | S810 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15297 | PPM1D | S40 | ochoa | Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) | Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257, ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23242139}. |
| O15409 | FOXP2 | S439 | ochoa | Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein) | Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. |
| O15417 | TNRC18 | S611 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43516 | WIPF1 | S154 | ochoa|psp | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O43516 | WIPF1 | S409 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O60641 | SNAP91 | S325 | ochoa | Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20) | Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}. |
| O60749 | SNX2 | S97 | ochoa | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). {ECO:0000269|PubMed:16179610, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:20138391, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:23085988, ECO:0000303|PubMed:16179610}. |
| O75147 | OBSL1 | S120 | ochoa | Obscurin-like protein 1 | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. {ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. |
| O75362 | ZNF217 | S795 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75385 | ULK1 | S758 | ochoa|psp | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O95359 | TACC2 | S124 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95429 | BAG4 | S245 | ochoa | BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
| O95613 | PCNT | S3242 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95785 | WIZ | S1127 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P07101 | TH | S44 | psp | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
| P0C1Z6 | TFPT | S167 | ochoa | TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) | Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| P10398 | ARAF | S186 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P10415 | BCL2 | S70 | ochoa|psp | Apoptosis regulator Bcl-2 | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:1508712, ECO:0000269|PubMed:17418785, ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20889974, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:8183370, ECO:0000303|PubMed:11368354}. |
| P15822 | HIVEP1 | S2682 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P17600 | SYN1 | S510 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18846 | ATF1 | S198 | ochoa|psp | Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36) | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| P18887 | XRCC1 | S268 | ochoa | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269|PubMed:11163244, ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403, ECO:0000269|PubMed:34102106, ECO:0000269|PubMed:34811483}. |
| P23769 | GATA2 | S73 | psp | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P40123 | CAP2 | S309 | ochoa | Adenylyl cyclase-associated protein 2 (CAP 2) | Involved in the regulation of actin polymerization. {ECO:0000269|PubMed:30518548}. |
| P41182 | BCL6 | S427 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P42226 | STAT6 | S756 | psp | Signal transducer and activator of transcription 6 (IL-4 Stat) | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}. |
| P42694 | HELZ | S1463 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P42695 | NCAPD3 | S1474 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P48681 | NES | S1307 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49327 | FASN | S831 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | S948 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49796 | RGS3 | S752 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P51617 | IRAK1 | S163 | psp | Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. {ECO:0000269|PubMed:11397809, ECO:0000269|PubMed:12860405, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:15465816, ECO:0000269|PubMed:15767370, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509}. |
| P52824 | DGKQ | S376 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
| P55199 | ELL | S319 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P68400 | CSNK2A1 | S370 | psp | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:19188443, PubMed:20545769, PubMed:20625391, PubMed:22017874, PubMed:22406621, PubMed:24962073, PubMed:30898438, PubMed:31439799). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387551, PubMed:19387552). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, MRE11, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:18411307, PubMed:18583988, PubMed:18678890, PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:28512243, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:16193064, PubMed:22184066). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064). Phosphorylates YY1, protecting YY1 from cleavage by CASP7 during apoptosis (PubMed:22184066). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552, PubMed:23123191). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387550, PubMed:19387551, PubMed:19387552). Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621). Plays an important role in the circadian clock function by phosphorylating BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Phosphorylates FMR1, promoting FMR1-dependent formation of a membraneless compartment (PubMed:30765518, PubMed:31439799). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000250|UniProtKB:P19139, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:19188443, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:22406621, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:24962073, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:28512243, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q01518 | CAP1 | S34 | ochoa | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q05707 | COL14A1 | S1648 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q12756 | KIF1A | S1094 | ochoa | Kinesin-like protein KIF1A (EC 5.6.1.3) (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | Kinesin motor with a plus-end-directed microtubule motor activity (By similarity). It is required for anterograde axonal transport of synaptic vesicle precursors (PubMed:33880452). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. {ECO:0000250|UniProtKB:F1M4A4, ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:33880452}. |
| Q12772 | SREBF2 | S117 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12815 | TROAP | S98 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13469 | NFATC2 | S53 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13950 | RUNX2 | S275 | ochoa|psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14653 | IRF3 | S173 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q15735 | INPP5J | S150 | ochoa | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.36) (Inositol polyphosphate 5-phosphatase J) (Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase) (EC 3.1.3.56) (Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.56) | Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. {ECO:0000250|UniProtKB:Q9JMC1}. |
| Q5EBL2 | ZNF628 | S340 | ochoa | Zinc finger protein 628 | Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis. {ECO:0000250|UniProtKB:Q8CJ78}. |
| Q5JVS0 | HABP4 | S108 | ochoa | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}. |
| Q5T0Z8 | C6orf132 | S736 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1R4 | HIVEP3 | S2127 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T6C5 | ATXN7L2 | S179 | ochoa | Ataxin-7-like protein 2 | None |
| Q5T6C5 | ATXN7L2 | S468 | ochoa | Ataxin-7-like protein 2 | None |
| Q5T6C5 | ATXN7L2 | S575 | ochoa | Ataxin-7-like protein 2 | None |
| Q5THK1 | PRR14L | S717 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5VST9 | OBSCN | S7023 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q63HR2 | TNS2 | S481 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q659A1 | ICE2 | S418 | ochoa | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. {ECO:0000269|PubMed:23932780}. |
| Q6F5E8 | CARMIL2 | S1321 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ23 | PLEKHA7 | S903 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NUJ5 | PWWP2B | S447 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6NUN9 | ZNF746 | S404 | ochoa | Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}. |
| Q6P1N0 | CC2D1A | S208 | ochoa|psp | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6PII3 | CCDC174 | S432 | ochoa | Coiled-coil domain-containing protein 174 | Probably involved in neuronal development. {ECO:0000269|PubMed:26358778}. |
| Q6PJG2 | MIDEAS | S636 | ochoa | Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) | None |
| Q6ZMD2 | SPNS3 | S21 | ochoa | Protein spinster homolog 3 | Sphingolipid transporter. {ECO:0000250}. |
| Q6ZTU2 | EP400P1 | S114 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q6ZU35 | CRACD | S543 | ochoa | Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}. |
| Q6ZU65 | UBN2 | S1029 | ochoa | Ubinuclein-2 | None |
| Q6ZVL6 | KIAA1549L | S1593 | ochoa | UPF0606 protein KIAA1549L | None |
| Q70E73 | RAPH1 | S610 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q7Z3K3 | POGZ | S314 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z591 | AKNA | S534 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S1013 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z5Q1 | CPEB2 | S164 | ochoa | Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (hCPEB-2) | May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0, ECO:0000269|PubMed:26398195}. |
| Q7Z6I6 | ARHGAP30 | S240 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86TB9 | PATL1 | S278 | ochoa | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}. |
| Q86UP3 | ZFHX4 | S608 | ochoa | Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) | May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}. |
| Q86UR5 | RIMS1 | S448 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
| Q86VE0 | MYPOP | S202 | ochoa | Myb-related transcription factor, partner of profilin (Myb-related protein p42POP) (Partner of profilin) | Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity). {ECO:0000250}. |
| Q86VQ1 | GLCCI1 | S76 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XJ1 | GAS2L3 | S418 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q8IUW3 | SPATA2L | S332 | ochoa | Spermatogenesis-associated protein 2-like protein (SPATA2-like protein) | None |
| Q8IWC1 | MAP7D3 | S290 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX03 | WWC1 | S535 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8IX07 | ZFPM1 | S786 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IX07 | ZFPM1 | S909 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXM2 | BACC1 | S110 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IYT8 | ULK2 | S780 | ochoa | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
| Q8N0Y2 | ZNF444 | S162 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N1G1 | REXO1 | S719 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N884 | CGAS | S143 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NBZ0 | INO80E | S106 | ochoa | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q8ND24 | RNF214 | S519 | ochoa | RING finger protein 214 | None |
| Q8NEY1 | NAV1 | S152 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S1883 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFH5 | NUP35 | S66 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
| Q8TD55 | PLEKHO2 | S217 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TEK3 | DOT1L | S471 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
| Q8WUA4 | GTF3C2 | S220 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUF5 | PPP1R13L | S345 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WUI4 | HDAC7 | S283 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q8WVT3 | TRAPPC12 | S182 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q92576 | PHF3 | S1796 | ochoa | PHD finger protein 3 | None |
| Q96B18 | DACT3 | S170 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96EV2 | RBM33 | S1045 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96JE7 | SEC16B | S258 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96JM3 | CHAMP1 | S145 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96L91 | EP400 | S125 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96PE1 | ADGRA2 | S1107 | ochoa | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}. |
| Q96ST3 | SIN3A | S274 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96ST3 | SIN3A | S277 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99081 | TCF12 | S198 | ochoa | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}. |
| Q99700 | ATXN2 | S709 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99958 | FOXC2 | S240 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQI5 | SGIP1 | S335 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BVI0 | PHF20 | S248 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BXB5 | OSBPL10 | S507 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BYB0 | SHANK3 | S1158 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZL4 | PPP1R12C | S499 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9BZL4 | PPP1R12C | S502 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9BZL4 | PPP1R12C | S604 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0D6 | FHDC1 | S1012 | ochoa | FH2 domain-containing protein 1 (Inverted formin-1) | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation (PubMed:18815276). Regulates Golgi ribbon formation (PubMed:26564798). Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly (PubMed:29742020). {ECO:0000269|PubMed:18815276, ECO:0000269|PubMed:26564798, ECO:0000269|PubMed:29742020}. |
| Q9H0E3 | SAP130 | S465 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H4M7 | PLEKHA4 | S575 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H6K5 | PRR36 | S308 | ochoa | Proline-rich protein 36 | None |
| Q9H6S3 | EPS8L2 | S463 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H987 | SYNPO2L | S421 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9H992 | MARCHF7 | S317 | ochoa | E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7) | E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}. |
| Q9HCS5 | EPB41L4A | S426 | ochoa | Band 4.1-like protein 4A (Erythrocyte membrane protein band 4.1-like 4A) (Protein NBL4) | None |
| Q9NPI6 | DCP1A | S315 | ochoa|psp | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NRR6 | INPP5E | S47 | ochoa | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250|UniProtKB:Q9JII1, ECO:0000269|PubMed:10764818}. |
| Q9NSC2 | SALL1 | S1119 | ochoa | Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1) | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250|UniProtKB:Q9ER74}. |
| Q9NYJ8 | TAB2 | S450 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459). {ECO:0000250|UniProtKB:Q99K90, ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:15327770, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:20493459, ECO:0000269|PubMed:22158122, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:33184450, ECO:0000269|PubMed:36681779}. |
| Q9P206 | NHSL3 | S832 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P2F5 | STOX2 | S172 | ochoa | Storkhead-box protein 2 | None |
| Q9P2R6 | RERE | S142 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Q9UHF7 | TRPS1 | S1066 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UHR4 | BAIAP2L1 | S295 | ochoa | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UIF9 | BAZ2A | S1370 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UIS9 | MBD1 | S518 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UJM3 | ERRFI1 | S334 | ochoa|psp | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UL51 | HCN2 | S754 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULI4 | KIF26A | S885 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULM3 | YEATS2 | S627 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9UMN6 | KMT2B | S1836 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMN6 | KMT2B | S1917 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPQ9 | TNRC6B | S879 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPQ9 | TNRC6B | S1221 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9Y2F5 | ICE1 | S1470 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y4B5 | MTCL1 | S253 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4F5 | CEP170B | S536 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S772 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y520 | PRRC2C | S2268 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y6W5 | WASF2 | S296 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q9Y6X6 | MYO16 | S1539 | ochoa | Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}. |
| P43403 | ZAP70 | S260 | Sugiyama | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P35658 | NUP214 | S430 | Sugiyama | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
| Q32MK0 | MYLK3 | S275 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000005 | 5.305 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000028 | 4.559 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000123 | 3.910 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.000229 | 3.640 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.002140 | 2.670 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000773 | 3.112 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000855 | 3.068 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000855 | 3.068 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.001037 | 2.984 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.001037 | 2.984 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.001138 | 2.944 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001359 | 2.867 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.001889 | 2.724 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.002042 | 2.690 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.001609 | 2.793 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.001138 | 2.944 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.001245 | 2.905 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.001762 | 2.754 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.002202 | 2.657 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.002042 | 2.690 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.002042 | 2.690 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.002202 | 2.657 |
| R-HSA-74160 | Gene expression (Transcription) | 0.001264 | 2.898 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.001745 | 2.758 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.001889 | 2.724 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.002324 | 2.634 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.002600 | 2.585 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.002572 | 2.590 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.002892 | 2.539 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.003135 | 2.504 |
| R-HSA-9659379 | Sensory processing of sound | 0.003141 | 2.503 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.003350 | 2.475 |
| R-HSA-73887 | Death Receptor Signaling | 0.003452 | 2.462 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.004404 | 2.356 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.005773 | 2.239 |
| R-HSA-75893 | TNF signaling | 0.006066 | 2.217 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.006400 | 2.194 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.006935 | 2.159 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.006549 | 2.184 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.006935 | 2.159 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.007102 | 2.149 |
| R-HSA-191859 | snRNP Assembly | 0.007102 | 2.149 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.007853 | 2.105 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.007853 | 2.105 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.008193 | 2.087 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008227 | 2.085 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.008248 | 2.084 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.009225 | 2.035 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.009546 | 2.020 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.010990 | 1.959 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.010990 | 1.959 |
| R-HSA-4839726 | Chromatin organization | 0.011332 | 1.946 |
| R-HSA-211000 | Gene Silencing by RNA | 0.011333 | 1.946 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.012392 | 1.907 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.012921 | 1.889 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.013324 | 1.875 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.013465 | 1.871 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.017478 | 1.758 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.014147 | 1.849 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.015716 | 1.804 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.017647 | 1.753 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.015856 | 1.800 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.015856 | 1.800 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.015806 | 1.801 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.015856 | 1.800 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.017647 | 1.753 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.017676 | 1.753 |
| R-HSA-68875 | Mitotic Prophase | 0.017987 | 1.745 |
| R-HSA-3371556 | Cellular response to heat stress | 0.018505 | 1.733 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.019014 | 1.721 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.019521 | 1.710 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.023504 | 1.629 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.022626 | 1.645 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.023504 | 1.629 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.023504 | 1.629 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.021681 | 1.664 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.021681 | 1.664 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.022315 | 1.651 |
| R-HSA-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | 0.032981 | 1.482 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.045014 | 1.347 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.027789 | 1.556 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.039728 | 1.401 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.039728 | 1.401 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.034752 | 1.459 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.035721 | 1.447 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.034794 | 1.458 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.037208 | 1.429 |
| R-HSA-3214847 | HATs acetylate histones | 0.035843 | 1.446 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.026631 | 1.575 |
| R-HSA-212436 | Generic Transcription Pathway | 0.028288 | 1.548 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.043259 | 1.364 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.027789 | 1.556 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.034819 | 1.458 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.043259 | 1.364 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.039728 | 1.401 |
| R-HSA-450294 | MAP kinase activation | 0.043020 | 1.366 |
| R-HSA-70171 | Glycolysis | 0.036853 | 1.434 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.042312 | 1.374 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.045014 | 1.347 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.046133 | 1.336 |
| R-HSA-9839394 | TGFBR3 expression | 0.047661 | 1.322 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.047661 | 1.322 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.047730 | 1.321 |
| R-HSA-162587 | HIV Life Cycle | 0.047821 | 1.320 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.049046 | 1.309 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.049046 | 1.309 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.050423 | 1.297 |
| R-HSA-418990 | Adherens junctions interactions | 0.052250 | 1.282 |
| R-HSA-9830369 | Kidney development | 0.052682 | 1.278 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.053241 | 1.274 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.054365 | 1.265 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.054365 | 1.265 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.054365 | 1.265 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.054365 | 1.265 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.054365 | 1.265 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.054365 | 1.265 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.056115 | 1.251 |
| R-HSA-1296061 | HCN channels | 0.064880 | 1.188 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.075279 | 1.123 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.075279 | 1.123 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.074813 | 1.126 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.075279 | 1.123 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.075279 | 1.123 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.075279 | 1.123 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.057872 | 1.238 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.071248 | 1.147 |
| R-HSA-9931529 | Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK | 0.075279 | 1.123 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.075279 | 1.123 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.074418 | 1.128 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.070876 | 1.150 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.070277 | 1.153 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.062019 | 1.207 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.057872 | 1.238 |
| R-HSA-448424 | Interleukin-17 signaling | 0.057872 | 1.238 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.074418 | 1.128 |
| R-HSA-1483257 | Phospholipid metabolism | 0.065010 | 1.187 |
| R-HSA-70326 | Glucose metabolism | 0.060485 | 1.218 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.085563 | 1.068 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.085563 | 1.068 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.105790 | 0.976 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.115737 | 0.937 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.115737 | 0.937 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.115737 | 0.937 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.144920 | 0.839 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.163842 | 0.786 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.163842 | 0.786 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.191446 | 0.718 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.191446 | 0.718 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.084189 | 1.075 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.182347 | 0.739 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.209344 | 0.679 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.209344 | 0.679 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.125573 | 0.901 |
| R-HSA-6807070 | PTEN Regulation | 0.098898 | 1.005 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 0.135300 | 0.869 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.154434 | 0.811 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.173146 | 0.762 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 0.191446 | 0.718 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.226847 | 0.644 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.226847 | 0.644 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 0.125573 | 0.901 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.135300 | 0.869 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 0.182347 | 0.739 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.122872 | 0.911 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.191446 | 0.718 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.226847 | 0.644 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.089422 | 1.049 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.172793 | 0.762 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.125573 | 0.901 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.087528 | 1.058 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.157069 | 0.804 |
| R-HSA-9663891 | Selective autophagy | 0.095885 | 1.018 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.154434 | 0.811 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.209344 | 0.679 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.154574 | 0.811 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.122872 | 0.911 |
| R-HSA-199920 | CREB phosphorylation | 0.095733 | 1.019 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.105790 | 0.976 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.125573 | 0.901 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.135300 | 0.869 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.154434 | 0.811 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.154434 | 0.811 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.163842 | 0.786 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.163842 | 0.786 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.173146 | 0.762 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.191446 | 0.718 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.123944 | 0.907 |
| R-HSA-68886 | M Phase | 0.167108 | 0.777 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.123944 | 0.907 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.123944 | 0.907 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.165270 | 0.782 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.173432 | 0.761 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.209466 | 0.679 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.187282 | 0.728 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.077632 | 1.110 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.209344 | 0.679 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.085582 | 1.068 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.126405 | 0.898 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.187282 | 0.728 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.195727 | 0.708 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.195727 | 0.708 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.116807 | 0.933 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 0.144920 | 0.839 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.163842 | 0.786 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.163842 | 0.786 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.163842 | 0.786 |
| R-HSA-8949664 | Processing of SMDT1 | 0.173146 | 0.762 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.191446 | 0.718 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.151935 | 0.818 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.093796 | 1.028 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.218144 | 0.661 |
| R-HSA-114608 | Platelet degranulation | 0.212886 | 0.672 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.135300 | 0.869 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.191446 | 0.718 |
| R-HSA-209905 | Catecholamine biosynthesis | 0.218144 | 0.661 |
| R-HSA-9609690 | HCMV Early Events | 0.221117 | 0.655 |
| R-HSA-199991 | Membrane Trafficking | 0.131302 | 0.882 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.149316 | 0.826 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.225315 | 0.647 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.173146 | 0.762 |
| R-HSA-983189 | Kinesins | 0.176764 | 0.753 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.130125 | 0.886 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.119076 | 0.924 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.138968 | 0.857 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.217134 | 0.663 |
| R-HSA-5205647 | Mitophagy | 0.077632 | 1.110 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.160974 | 0.793 |
| R-HSA-162906 | HIV Infection | 0.144824 | 0.839 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.126576 | 0.898 |
| R-HSA-9610379 | HCMV Late Events | 0.134043 | 0.873 |
| R-HSA-111458 | Formation of apoptosome | 0.135300 | 0.869 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.085067 | 1.070 |
| R-HSA-157118 | Signaling by NOTCH | 0.167788 | 0.775 |
| R-HSA-421270 | Cell-cell junction organization | 0.085173 | 1.070 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.176764 | 0.753 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.184748 | 0.733 |
| R-HSA-446728 | Cell junction organization | 0.118976 | 0.925 |
| R-HSA-168255 | Influenza Infection | 0.182292 | 0.739 |
| R-HSA-1500931 | Cell-Cell communication | 0.176040 | 0.754 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.135300 | 0.869 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.120548 | 0.919 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.225315 | 0.647 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.090907 | 1.041 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.134061 | 0.873 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.130306 | 0.885 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.157069 | 0.804 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.176764 | 0.753 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.176764 | 0.753 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.176764 | 0.753 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.176764 | 0.753 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.149311 | 0.826 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.126405 | 0.898 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.208982 | 0.680 |
| R-HSA-1483255 | PI Metabolism | 0.133893 | 0.873 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.149311 | 0.826 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.198563 | 0.702 |
| R-HSA-2028269 | Signaling by Hippo | 0.218144 | 0.661 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.121653 | 0.915 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.130306 | 0.885 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.176764 | 0.753 |
| R-HSA-72306 | tRNA processing | 0.162754 | 0.788 |
| R-HSA-5619102 | SLC transporter disorders | 0.154330 | 0.812 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.230561 | 0.637 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.233295 | 0.632 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.237626 | 0.624 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.237626 | 0.624 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.237709 | 0.624 |
| R-HSA-5689603 | UCH proteinases | 0.241739 | 0.617 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.241739 | 0.617 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.243965 | 0.613 |
| R-HSA-445144 | Signal transduction by L1 | 0.243965 | 0.613 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.243996 | 0.613 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.252383 | 0.598 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.252383 | 0.598 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.258216 | 0.588 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.258765 | 0.587 |
| R-HSA-1632852 | Macroautophagy | 0.260017 | 0.585 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.260707 | 0.584 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.260707 | 0.584 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.260707 | 0.584 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.260707 | 0.584 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.264340 | 0.578 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.268938 | 0.570 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.269016 | 0.570 |
| R-HSA-2262752 | Cellular responses to stress | 0.273648 | 0.563 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.274709 | 0.561 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.277079 | 0.557 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.277635 | 0.557 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.281071 | 0.551 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.282952 | 0.548 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.285130 | 0.545 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.285130 | 0.545 |
| R-HSA-109582 | Hemostasis | 0.290702 | 0.537 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.293174 | 0.533 |
| R-HSA-913531 | Interferon Signaling | 0.298724 | 0.525 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.300964 | 0.521 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.300964 | 0.521 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.300964 | 0.521 |
| R-HSA-525793 | Myogenesis | 0.300964 | 0.521 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.300964 | 0.521 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.300964 | 0.521 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.302016 | 0.520 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.303516 | 0.518 |
| R-HSA-9612973 | Autophagy | 0.308351 | 0.511 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.308750 | 0.510 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.308750 | 0.510 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 0.308750 | 0.510 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.316450 | 0.500 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.316450 | 0.500 |
| R-HSA-622312 | Inflammasomes | 0.316450 | 0.500 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.320515 | 0.494 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.323633 | 0.490 |
| R-HSA-8939211 | ESR-mediated signaling | 0.324052 | 0.489 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.324064 | 0.489 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.324064 | 0.489 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.324064 | 0.489 |
| R-HSA-109581 | Apoptosis | 0.326600 | 0.486 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.331594 | 0.479 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.331594 | 0.479 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.331594 | 0.479 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.336180 | 0.473 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.336180 | 0.473 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.339041 | 0.470 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.339041 | 0.470 |
| R-HSA-186763 | Downstream signal transduction | 0.339041 | 0.470 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.341057 | 0.467 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.349269 | 0.457 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.353688 | 0.451 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.353688 | 0.451 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.353688 | 0.451 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.353688 | 0.451 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.353688 | 0.451 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.356373 | 0.448 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.356373 | 0.448 |
| R-HSA-9609646 | HCMV Infection | 0.356846 | 0.448 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.356994 | 0.447 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.360027 | 0.444 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.360889 | 0.443 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.360889 | 0.443 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.360889 | 0.443 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.360889 | 0.443 |
| R-HSA-5673000 | RAF activation | 0.368012 | 0.434 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.368012 | 0.434 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.372370 | 0.429 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.372370 | 0.429 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.375055 | 0.426 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.375055 | 0.426 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.380333 | 0.420 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.382020 | 0.418 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.382020 | 0.418 |
| R-HSA-8853659 | RET signaling | 0.382020 | 0.418 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.382020 | 0.418 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.388908 | 0.410 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.388908 | 0.410 |
| R-HSA-8948216 | Collagen chain trimerization | 0.388908 | 0.410 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.392282 | 0.406 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.393217 | 0.405 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.395719 | 0.403 |
| R-HSA-202403 | TCR signaling | 0.396061 | 0.402 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.402205 | 0.396 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.402455 | 0.395 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.402455 | 0.395 |
| R-HSA-201556 | Signaling by ALK | 0.402455 | 0.395 |
| R-HSA-69541 | Stabilization of p53 | 0.402455 | 0.395 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.402455 | 0.395 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.402455 | 0.395 |
| R-HSA-9646399 | Aggrephagy | 0.409116 | 0.388 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.409116 | 0.388 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.409116 | 0.388 |
| R-HSA-167169 | HIV Transcription Elongation | 0.409116 | 0.388 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.409116 | 0.388 |
| R-HSA-202433 | Generation of second messenger molecules | 0.409116 | 0.388 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.415704 | 0.381 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.415704 | 0.381 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.415704 | 0.381 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.417224 | 0.380 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.422218 | 0.374 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.422218 | 0.374 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.422218 | 0.374 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.422218 | 0.374 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.422218 | 0.374 |
| R-HSA-68877 | Mitotic Prometaphase | 0.423009 | 0.374 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.423173 | 0.373 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.423173 | 0.373 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.430739 | 0.366 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.430806 | 0.366 |
| R-HSA-449147 | Signaling by Interleukins | 0.434839 | 0.362 |
| R-HSA-8854214 | TBC/RABGAPs | 0.435031 | 0.361 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.443572 | 0.353 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.445909 | 0.351 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.449396 | 0.347 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.452299 | 0.345 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.453723 | 0.343 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.453723 | 0.343 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.453723 | 0.343 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.453723 | 0.343 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.453723 | 0.343 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.453723 | 0.343 |
| R-HSA-1483191 | Synthesis of PC | 0.459816 | 0.337 |
| R-HSA-162582 | Signal Transduction | 0.460513 | 0.337 |
| R-HSA-5357801 | Programmed Cell Death | 0.460970 | 0.336 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.464472 | 0.333 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-9679506 | SARS-CoV Infections | 0.465035 | 0.333 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.471799 | 0.326 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.471799 | 0.326 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.475434 | 0.323 |
| R-HSA-195721 | Signaling by WNT | 0.476289 | 0.322 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.484771 | 0.314 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.489281 | 0.310 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.489281 | 0.310 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.489281 | 0.310 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.489281 | 0.310 |
| R-HSA-68882 | Mitotic Anaphase | 0.492244 | 0.308 |
| R-HSA-9909396 | Circadian clock | 0.493401 | 0.307 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.494979 | 0.305 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.494979 | 0.305 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.495044 | 0.305 |
| R-HSA-163685 | Integration of energy metabolism | 0.510977 | 0.292 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.511697 | 0.291 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.511697 | 0.291 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.511697 | 0.291 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.514444 | 0.289 |
| R-HSA-1483166 | Synthesis of PA | 0.517147 | 0.286 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.522536 | 0.282 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.522536 | 0.282 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.524749 | 0.280 |
| R-HSA-9664407 | Parasite infection | 0.524749 | 0.280 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.524749 | 0.280 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.527865 | 0.277 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.528151 | 0.277 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.533136 | 0.273 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.538347 | 0.269 |
| R-HSA-1442490 | Collagen degradation | 0.538347 | 0.269 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.543501 | 0.265 |
| R-HSA-1268020 | Mitochondrial protein import | 0.543501 | 0.265 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.543501 | 0.265 |
| R-HSA-9707616 | Heme signaling | 0.543501 | 0.265 |
| R-HSA-186797 | Signaling by PDGF | 0.543501 | 0.265 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.548597 | 0.261 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.548597 | 0.261 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.548597 | 0.261 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.553637 | 0.257 |
| R-HSA-166520 | Signaling by NTRKs | 0.554774 | 0.256 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.558621 | 0.253 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.558621 | 0.253 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.563550 | 0.249 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.563550 | 0.249 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.566372 | 0.247 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.567684 | 0.246 |
| R-HSA-1640170 | Cell Cycle | 0.571263 | 0.243 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.573244 | 0.242 |
| R-HSA-167172 | Transcription of the HIV genome | 0.573244 | 0.242 |
| R-HSA-5218859 | Regulated Necrosis | 0.573244 | 0.242 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.582723 | 0.235 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.582723 | 0.235 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.583442 | 0.234 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.586543 | 0.232 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.587384 | 0.231 |
| R-HSA-877300 | Interferon gamma signaling | 0.589627 | 0.229 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.591993 | 0.228 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.592693 | 0.227 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.596551 | 0.224 |
| R-HSA-4086398 | Ca2+ pathway | 0.596551 | 0.224 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.596551 | 0.224 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.597654 | 0.224 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.601059 | 0.221 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.601059 | 0.221 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.601059 | 0.221 |
| R-HSA-380287 | Centrosome maturation | 0.605516 | 0.218 |
| R-HSA-73894 | DNA Repair | 0.616084 | 0.210 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.618593 | 0.209 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.618593 | 0.209 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.618593 | 0.209 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.636655 | 0.196 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.639436 | 0.194 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.643467 | 0.191 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.647453 | 0.189 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.647453 | 0.189 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.647453 | 0.189 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.651395 | 0.186 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.651395 | 0.186 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.651395 | 0.186 |
| R-HSA-1280218 | Adaptive Immune System | 0.652118 | 0.186 |
| R-HSA-2559583 | Cellular Senescence | 0.653176 | 0.185 |
| R-HSA-168249 | Innate Immune System | 0.654085 | 0.184 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.655292 | 0.184 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.659147 | 0.181 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.662958 | 0.179 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.670455 | 0.174 |
| R-HSA-73884 | Base Excision Repair | 0.670455 | 0.174 |
| R-HSA-202424 | Downstream TCR signaling | 0.670455 | 0.174 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.674141 | 0.171 |
| R-HSA-5617833 | Cilium Assembly | 0.679381 | 0.168 |
| R-HSA-391251 | Protein folding | 0.681390 | 0.167 |
| R-HSA-1474290 | Collagen formation | 0.688478 | 0.162 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.688478 | 0.162 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.691964 | 0.160 |
| R-HSA-168256 | Immune System | 0.698418 | 0.156 |
| R-HSA-1296071 | Potassium Channels | 0.698818 | 0.156 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.698818 | 0.156 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.711022 | 0.148 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.712076 | 0.147 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.718486 | 0.144 |
| R-HSA-9833110 | RSV-host interactions | 0.727835 | 0.138 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.733895 | 0.134 |
| R-HSA-8957322 | Metabolism of steroids | 0.741478 | 0.130 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.742735 | 0.129 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.751283 | 0.124 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.751283 | 0.124 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.754070 | 0.123 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.762243 | 0.118 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.764907 | 0.116 |
| R-HSA-373760 | L1CAM interactions | 0.767541 | 0.115 |
| R-HSA-5693538 | Homology Directed Repair | 0.772722 | 0.112 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.780279 | 0.108 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.781412 | 0.107 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.785178 | 0.105 |
| R-HSA-194138 | Signaling by VEGF | 0.792322 | 0.101 |
| R-HSA-112316 | Neuronal System | 0.798787 | 0.098 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.803709 | 0.095 |
| R-HSA-9675108 | Nervous system development | 0.807275 | 0.093 |
| R-HSA-9843745 | Adipogenesis | 0.808088 | 0.093 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.810241 | 0.091 |
| R-HSA-5688426 | Deubiquitination | 0.814160 | 0.089 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.818884 | 0.087 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.820650 | 0.086 |
| R-HSA-416476 | G alpha (q) signalling events | 0.828010 | 0.082 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.837976 | 0.077 |
| R-HSA-9758941 | Gastrulation | 0.846872 | 0.072 |
| R-HSA-8953854 | Metabolism of RNA | 0.847416 | 0.072 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.851672 | 0.070 |
| R-HSA-9658195 | Leishmania infection | 0.851672 | 0.070 |
| R-HSA-9609507 | Protein localization | 0.853637 | 0.069 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.853637 | 0.069 |
| R-HSA-1989781 | PPARA activates gene expression | 0.856907 | 0.067 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.870748 | 0.060 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.874778 | 0.058 |
| R-HSA-422475 | Axon guidance | 0.880111 | 0.055 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.887151 | 0.052 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.895186 | 0.048 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.897990 | 0.047 |
| R-HSA-69275 | G2/M Transition | 0.900362 | 0.046 |
| R-HSA-9824446 | Viral Infection Pathways | 0.900868 | 0.045 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.902593 | 0.045 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.908992 | 0.041 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.918041 | 0.037 |
| R-HSA-72172 | mRNA Splicing | 0.919658 | 0.036 |
| R-HSA-8951664 | Neddylation | 0.933747 | 0.030 |
| R-HSA-1266738 | Developmental Biology | 0.935766 | 0.029 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.940181 | 0.027 |
| R-HSA-597592 | Post-translational protein modification | 0.943487 | 0.025 |
| R-HSA-556833 | Metabolism of lipids | 0.955550 | 0.020 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.966887 | 0.015 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.969425 | 0.013 |
| R-HSA-6798695 | Neutrophil degranulation | 0.971310 | 0.013 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.971770 | 0.012 |
| R-HSA-1474244 | Extracellular matrix organization | 0.981068 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.987020 | 0.006 |
| R-HSA-5663205 | Infectious disease | 0.987047 | 0.006 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.989679 | 0.005 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992163 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.992163 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.994073 | 0.003 |
| R-HSA-1643685 | Disease | 0.997218 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.997310 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.997641 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 0.998733 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999317 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999990 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.860 | 0.860 | 1 | 0.874 |
HIPK2 |
0.857 | 0.789 | 1 | 0.869 |
P38G |
0.855 | 0.880 | 1 | 0.905 |
CDK19 |
0.854 | 0.833 | 1 | 0.867 |
CDK17 |
0.853 | 0.861 | 1 | 0.897 |
KIS |
0.853 | 0.758 | 1 | 0.811 |
CDK3 |
0.852 | 0.760 | 1 | 0.891 |
P38D |
0.849 | 0.866 | 1 | 0.909 |
JNK2 |
0.849 | 0.883 | 1 | 0.868 |
CDK1 |
0.848 | 0.823 | 1 | 0.853 |
CDK8 |
0.847 | 0.828 | 1 | 0.836 |
CDK16 |
0.846 | 0.823 | 1 | 0.885 |
CDK7 |
0.846 | 0.825 | 1 | 0.835 |
CDK5 |
0.844 | 0.808 | 1 | 0.810 |
ERK1 |
0.843 | 0.837 | 1 | 0.855 |
CDK12 |
0.842 | 0.834 | 1 | 0.869 |
DYRK2 |
0.842 | 0.772 | 1 | 0.791 |
CDK13 |
0.842 | 0.829 | 1 | 0.851 |
P38B |
0.841 | 0.844 | 1 | 0.839 |
CDK10 |
0.839 | 0.780 | 1 | 0.851 |
JNK3 |
0.838 | 0.864 | 1 | 0.844 |
DYRK4 |
0.836 | 0.768 | 1 | 0.876 |
HIPK1 |
0.835 | 0.720 | 1 | 0.773 |
CDK14 |
0.835 | 0.817 | 1 | 0.836 |
CDK9 |
0.834 | 0.813 | 1 | 0.844 |
HIPK4 |
0.833 | 0.546 | 1 | 0.588 |
P38A |
0.831 | 0.818 | 1 | 0.782 |
CLK3 |
0.830 | 0.514 | 1 | 0.541 |
DYRK1B |
0.827 | 0.735 | 1 | 0.831 |
CDK6 |
0.824 | 0.790 | 1 | 0.853 |
CDK4 |
0.821 | 0.807 | 1 | 0.877 |
SRPK1 |
0.821 | 0.373 | -3 | 0.743 |
NLK |
0.821 | 0.748 | 1 | 0.581 |
ERK2 |
0.821 | 0.810 | 1 | 0.807 |
HIPK3 |
0.820 | 0.694 | 1 | 0.741 |
JNK1 |
0.820 | 0.774 | 1 | 0.864 |
DYRK1A |
0.819 | 0.628 | 1 | 0.747 |
CLK2 |
0.815 | 0.432 | -3 | 0.738 |
CDK2 |
0.813 | 0.629 | 1 | 0.738 |
MAK |
0.811 | 0.540 | -2 | 0.795 |
DYRK3 |
0.810 | 0.563 | 1 | 0.741 |
ERK5 |
0.810 | 0.429 | 1 | 0.497 |
CLK1 |
0.809 | 0.429 | -3 | 0.730 |
SRPK2 |
0.807 | 0.293 | -3 | 0.664 |
CLK4 |
0.803 | 0.391 | -3 | 0.748 |
MTOR |
0.803 | 0.266 | 1 | 0.374 |
ICK |
0.801 | 0.393 | -3 | 0.828 |
CDKL5 |
0.799 | 0.203 | -3 | 0.789 |
MOK |
0.796 | 0.495 | 1 | 0.667 |
COT |
0.796 | -0.040 | 2 | 0.845 |
SRPK3 |
0.795 | 0.262 | -3 | 0.707 |
PRP4 |
0.794 | 0.504 | -3 | 0.815 |
CDKL1 |
0.792 | 0.169 | -3 | 0.793 |
ERK7 |
0.787 | 0.316 | 2 | 0.604 |
PRKD1 |
0.787 | 0.048 | -3 | 0.831 |
CDC7 |
0.786 | -0.061 | 1 | 0.202 |
MOS |
0.785 | 0.012 | 1 | 0.250 |
PRKD2 |
0.783 | 0.039 | -3 | 0.773 |
PIM3 |
0.782 | -0.010 | -3 | 0.828 |
MST4 |
0.782 | -0.002 | 2 | 0.852 |
NDR2 |
0.782 | -0.003 | -3 | 0.834 |
CHAK2 |
0.781 | -0.001 | -1 | 0.837 |
PRPK |
0.780 | -0.074 | -1 | 0.832 |
ATR |
0.780 | -0.022 | 1 | 0.254 |
AURC |
0.779 | 0.052 | -2 | 0.648 |
TBK1 |
0.779 | -0.140 | 1 | 0.168 |
RSK2 |
0.779 | 0.023 | -3 | 0.764 |
GCN2 |
0.776 | -0.175 | 2 | 0.776 |
WNK1 |
0.775 | -0.056 | -2 | 0.841 |
RSK3 |
0.775 | 0.004 | -3 | 0.760 |
PKN3 |
0.775 | -0.030 | -3 | 0.820 |
SKMLCK |
0.774 | -0.022 | -2 | 0.835 |
PKN2 |
0.774 | -0.035 | -3 | 0.832 |
IKKE |
0.774 | -0.156 | 1 | 0.167 |
NDR1 |
0.774 | -0.040 | -3 | 0.829 |
PKCD |
0.774 | 0.003 | 2 | 0.776 |
P90RSK |
0.774 | 0.016 | -3 | 0.765 |
CAMK1B |
0.774 | -0.034 | -3 | 0.845 |
ULK2 |
0.774 | -0.165 | 2 | 0.767 |
IKKB |
0.773 | -0.154 | -2 | 0.714 |
RAF1 |
0.773 | -0.182 | 1 | 0.196 |
NEK6 |
0.773 | -0.073 | -2 | 0.812 |
NUAK2 |
0.773 | 0.008 | -3 | 0.827 |
NIK |
0.772 | -0.033 | -3 | 0.866 |
PIM1 |
0.772 | 0.026 | -3 | 0.776 |
PDHK4 |
0.772 | -0.161 | 1 | 0.261 |
BMPR2 |
0.771 | -0.159 | -2 | 0.841 |
PKCB |
0.771 | 0.007 | 2 | 0.741 |
TGFBR2 |
0.771 | -0.074 | -2 | 0.758 |
PKCA |
0.771 | 0.025 | 2 | 0.733 |
IRE1 |
0.770 | -0.057 | 1 | 0.210 |
GSK3A |
0.770 | 0.226 | 4 | 0.467 |
DSTYK |
0.769 | -0.153 | 2 | 0.855 |
MLK2 |
0.769 | -0.054 | 2 | 0.815 |
CAMLCK |
0.769 | -0.007 | -2 | 0.822 |
PKACG |
0.769 | -0.017 | -2 | 0.715 |
MPSK1 |
0.768 | 0.112 | 1 | 0.284 |
RIPK3 |
0.768 | -0.125 | 3 | 0.684 |
MNK2 |
0.768 | -0.009 | -2 | 0.764 |
MLK3 |
0.767 | -0.032 | 2 | 0.741 |
MNK1 |
0.767 | 0.012 | -2 | 0.777 |
AMPKA1 |
0.767 | -0.055 | -3 | 0.848 |
MLK1 |
0.767 | -0.133 | 2 | 0.804 |
GRK1 |
0.766 | -0.035 | -2 | 0.754 |
PDHK1 |
0.766 | -0.177 | 1 | 0.242 |
DAPK2 |
0.766 | -0.029 | -3 | 0.851 |
PKCG |
0.766 | -0.007 | 2 | 0.736 |
P70S6KB |
0.766 | -0.011 | -3 | 0.783 |
MAPKAPK3 |
0.766 | -0.052 | -3 | 0.780 |
PKCZ |
0.766 | -0.009 | 2 | 0.788 |
PKACB |
0.765 | 0.031 | -2 | 0.654 |
PHKG1 |
0.765 | -0.046 | -3 | 0.817 |
AMPKA2 |
0.764 | -0.033 | -3 | 0.818 |
MARK4 |
0.764 | -0.066 | 4 | 0.780 |
PRKD3 |
0.764 | 0.000 | -3 | 0.731 |
GRK5 |
0.764 | -0.145 | -3 | 0.833 |
IKKA |
0.764 | -0.088 | -2 | 0.713 |
MAPKAPK2 |
0.764 | -0.032 | -3 | 0.736 |
PAK1 |
0.764 | -0.027 | -2 | 0.766 |
NEK7 |
0.763 | -0.192 | -3 | 0.821 |
CAMK2G |
0.763 | -0.131 | 2 | 0.741 |
LATS2 |
0.763 | -0.056 | -5 | 0.699 |
GRK7 |
0.763 | -0.004 | 1 | 0.216 |
AKT2 |
0.763 | 0.039 | -3 | 0.675 |
NEK9 |
0.762 | -0.146 | 2 | 0.831 |
RSK4 |
0.762 | 0.015 | -3 | 0.733 |
PAK6 |
0.762 | 0.010 | -2 | 0.679 |
PAK3 |
0.762 | -0.049 | -2 | 0.755 |
TSSK1 |
0.762 | -0.038 | -3 | 0.868 |
ULK1 |
0.762 | -0.176 | -3 | 0.799 |
SGK3 |
0.762 | 0.012 | -3 | 0.767 |
PKG2 |
0.761 | 0.007 | -2 | 0.662 |
IRE2 |
0.761 | -0.060 | 2 | 0.742 |
PKR |
0.761 | -0.040 | 1 | 0.226 |
NIM1 |
0.761 | -0.074 | 3 | 0.693 |
CAMK2D |
0.761 | -0.096 | -3 | 0.835 |
HUNK |
0.760 | -0.158 | 2 | 0.784 |
LATS1 |
0.760 | 0.009 | -3 | 0.842 |
MASTL |
0.759 | -0.159 | -2 | 0.760 |
BMPR1B |
0.759 | -0.048 | 1 | 0.173 |
VRK2 |
0.759 | 0.080 | 1 | 0.308 |
SMG1 |
0.759 | -0.048 | 1 | 0.240 |
AURB |
0.759 | 0.001 | -2 | 0.642 |
WNK3 |
0.758 | -0.213 | 1 | 0.202 |
PRKX |
0.758 | 0.036 | -3 | 0.674 |
BCKDK |
0.757 | -0.171 | -1 | 0.750 |
TSSK2 |
0.757 | -0.082 | -5 | 0.796 |
CHAK1 |
0.757 | -0.108 | 2 | 0.792 |
DNAPK |
0.757 | -0.042 | 1 | 0.231 |
PKCH |
0.756 | -0.044 | 2 | 0.719 |
RIPK1 |
0.756 | -0.186 | 1 | 0.193 |
DLK |
0.756 | -0.202 | 1 | 0.212 |
YSK4 |
0.755 | -0.125 | 1 | 0.183 |
PIM2 |
0.755 | 0.025 | -3 | 0.735 |
TTBK2 |
0.755 | -0.176 | 2 | 0.696 |
NUAK1 |
0.755 | -0.048 | -3 | 0.776 |
ALK4 |
0.755 | -0.063 | -2 | 0.797 |
NEK2 |
0.755 | -0.102 | 2 | 0.822 |
MST3 |
0.755 | -0.010 | 2 | 0.845 |
MELK |
0.754 | -0.078 | -3 | 0.800 |
PINK1 |
0.754 | 0.148 | 1 | 0.419 |
QSK |
0.754 | -0.039 | 4 | 0.760 |
TGFBR1 |
0.753 | -0.057 | -2 | 0.769 |
MSK2 |
0.753 | -0.048 | -3 | 0.735 |
GSK3B |
0.752 | 0.076 | 4 | 0.462 |
ANKRD3 |
0.752 | -0.200 | 1 | 0.218 |
MLK4 |
0.752 | -0.098 | 2 | 0.722 |
ATM |
0.752 | -0.100 | 1 | 0.217 |
MSK1 |
0.752 | -0.020 | -3 | 0.746 |
AKT1 |
0.752 | 0.016 | -3 | 0.700 |
DCAMKL1 |
0.751 | -0.039 | -3 | 0.778 |
CAMK2A |
0.750 | -0.049 | 2 | 0.720 |
QIK |
0.750 | -0.109 | -3 | 0.816 |
BUB1 |
0.750 | 0.076 | -5 | 0.748 |
PKCT |
0.750 | -0.035 | 2 | 0.729 |
GRK6 |
0.750 | -0.169 | 1 | 0.189 |
TLK2 |
0.750 | -0.115 | 1 | 0.204 |
CAMK4 |
0.750 | -0.134 | -3 | 0.806 |
PAK2 |
0.749 | -0.074 | -2 | 0.744 |
SIK |
0.749 | -0.056 | -3 | 0.741 |
TAO3 |
0.748 | -0.025 | 1 | 0.231 |
PKCI |
0.748 | -0.009 | 2 | 0.758 |
IRAK4 |
0.747 | -0.101 | 1 | 0.188 |
PKCE |
0.747 | 0.015 | 2 | 0.727 |
PLK4 |
0.746 | -0.128 | 2 | 0.602 |
CAMK2B |
0.745 | -0.099 | 2 | 0.702 |
BRSK2 |
0.745 | -0.104 | -3 | 0.805 |
PLK1 |
0.745 | -0.167 | -2 | 0.750 |
PKACA |
0.745 | 0.006 | -2 | 0.614 |
NEK5 |
0.745 | -0.109 | 1 | 0.203 |
ACVR2B |
0.745 | -0.106 | -2 | 0.767 |
PAK5 |
0.744 | -0.022 | -2 | 0.619 |
MEK1 |
0.744 | -0.171 | 2 | 0.804 |
GRK4 |
0.744 | -0.203 | -2 | 0.790 |
PHKG2 |
0.744 | -0.079 | -3 | 0.783 |
WNK4 |
0.744 | -0.114 | -2 | 0.833 |
MARK3 |
0.744 | -0.058 | 4 | 0.713 |
MEKK1 |
0.744 | -0.131 | 1 | 0.215 |
AKT3 |
0.743 | 0.029 | -3 | 0.623 |
MYLK4 |
0.743 | -0.056 | -2 | 0.741 |
FAM20C |
0.743 | -0.064 | 2 | 0.529 |
LKB1 |
0.743 | 0.010 | -3 | 0.835 |
AURA |
0.743 | -0.032 | -2 | 0.620 |
BRSK1 |
0.743 | -0.088 | -3 | 0.781 |
MEK5 |
0.743 | -0.151 | 2 | 0.802 |
SSTK |
0.743 | -0.045 | 4 | 0.747 |
ZAK |
0.743 | -0.151 | 1 | 0.195 |
MEKK2 |
0.743 | -0.112 | 2 | 0.787 |
ACVR2A |
0.742 | -0.114 | -2 | 0.753 |
PERK |
0.742 | -0.143 | -2 | 0.790 |
PAK4 |
0.742 | -0.011 | -2 | 0.628 |
TNIK |
0.741 | 0.002 | 3 | 0.841 |
CHK1 |
0.741 | -0.080 | -3 | 0.837 |
HGK |
0.740 | -0.021 | 3 | 0.840 |
MEKK6 |
0.740 | -0.048 | 1 | 0.214 |
CAMK1G |
0.740 | -0.078 | -3 | 0.741 |
MAPKAPK5 |
0.740 | -0.108 | -3 | 0.715 |
HRI |
0.740 | -0.169 | -2 | 0.803 |
P70S6K |
0.740 | -0.035 | -3 | 0.698 |
ALK2 |
0.739 | -0.105 | -2 | 0.773 |
DRAK1 |
0.739 | -0.159 | 1 | 0.157 |
CK1E |
0.739 | -0.040 | -3 | 0.509 |
PASK |
0.739 | -0.037 | -3 | 0.843 |
GRK2 |
0.739 | -0.097 | -2 | 0.707 |
MAP3K15 |
0.739 | -0.050 | 1 | 0.208 |
KHS1 |
0.738 | 0.006 | 1 | 0.201 |
GCK |
0.738 | -0.044 | 1 | 0.207 |
PKN1 |
0.738 | -0.027 | -3 | 0.715 |
HASPIN |
0.738 | 0.057 | -1 | 0.745 |
TAO2 |
0.738 | -0.046 | 2 | 0.834 |
DCAMKL2 |
0.738 | -0.070 | -3 | 0.795 |
MARK2 |
0.738 | -0.083 | 4 | 0.680 |
NEK11 |
0.737 | -0.124 | 1 | 0.218 |
GAK |
0.737 | -0.033 | 1 | 0.255 |
SGK1 |
0.737 | 0.036 | -3 | 0.607 |
MEKK3 |
0.737 | -0.189 | 1 | 0.208 |
PDK1 |
0.737 | -0.053 | 1 | 0.229 |
PBK |
0.737 | 0.002 | 1 | 0.238 |
SNRK |
0.736 | -0.178 | 2 | 0.658 |
LOK |
0.736 | -0.036 | -2 | 0.726 |
HPK1 |
0.735 | -0.040 | 1 | 0.203 |
KHS2 |
0.735 | 0.014 | 1 | 0.212 |
SMMLCK |
0.735 | -0.053 | -3 | 0.805 |
BRAF |
0.735 | -0.151 | -4 | 0.836 |
BMPR1A |
0.735 | -0.083 | 1 | 0.163 |
MINK |
0.734 | -0.074 | 1 | 0.187 |
PLK3 |
0.734 | -0.156 | 2 | 0.705 |
EEF2K |
0.733 | -0.047 | 3 | 0.798 |
NEK4 |
0.733 | -0.124 | 1 | 0.188 |
ROCK2 |
0.732 | 0.005 | -3 | 0.784 |
TLK1 |
0.732 | -0.176 | -2 | 0.792 |
LRRK2 |
0.732 | -0.003 | 2 | 0.835 |
NEK8 |
0.732 | -0.161 | 2 | 0.811 |
MRCKB |
0.731 | -0.001 | -3 | 0.727 |
SBK |
0.731 | 0.101 | -3 | 0.563 |
CK1G1 |
0.730 | -0.074 | -3 | 0.486 |
CK1D |
0.730 | -0.021 | -3 | 0.455 |
MARK1 |
0.730 | -0.114 | 4 | 0.727 |
CAMKK2 |
0.730 | -0.117 | -2 | 0.724 |
DAPK3 |
0.728 | -0.046 | -3 | 0.783 |
MST2 |
0.728 | -0.129 | 1 | 0.194 |
NEK1 |
0.728 | -0.110 | 1 | 0.184 |
CAMKK1 |
0.728 | -0.177 | -2 | 0.717 |
YSK1 |
0.728 | -0.067 | 2 | 0.815 |
SLK |
0.727 | -0.060 | -2 | 0.677 |
TTBK1 |
0.726 | -0.178 | 2 | 0.609 |
MRCKA |
0.726 | -0.023 | -3 | 0.742 |
CK1A2 |
0.725 | -0.045 | -3 | 0.455 |
CHK2 |
0.724 | -0.035 | -3 | 0.627 |
DMPK1 |
0.724 | 0.027 | -3 | 0.747 |
CAMK1D |
0.724 | -0.068 | -3 | 0.672 |
VRK1 |
0.723 | -0.147 | 2 | 0.825 |
GRK3 |
0.723 | -0.104 | -2 | 0.668 |
MST1 |
0.722 | -0.133 | 1 | 0.186 |
NEK3 |
0.722 | -0.080 | 1 | 0.213 |
DAPK1 |
0.722 | -0.052 | -3 | 0.765 |
CK2A2 |
0.722 | -0.095 | 1 | 0.148 |
PKG1 |
0.721 | -0.028 | -2 | 0.594 |
STK33 |
0.721 | -0.125 | 2 | 0.591 |
TAK1 |
0.720 | -0.177 | 1 | 0.192 |
AAK1 |
0.720 | 0.024 | 1 | 0.245 |
CRIK |
0.720 | 0.018 | -3 | 0.704 |
IRAK1 |
0.719 | -0.242 | -1 | 0.727 |
BIKE |
0.718 | -0.024 | 1 | 0.242 |
ROCK1 |
0.718 | -0.014 | -3 | 0.746 |
CAMK1A |
0.718 | -0.046 | -3 | 0.646 |
LIMK2_TYR |
0.718 | 0.184 | -3 | 0.891 |
MYO3B |
0.718 | -0.028 | 2 | 0.832 |
PDHK3_TYR |
0.717 | 0.159 | 4 | 0.837 |
OSR1 |
0.716 | -0.069 | 2 | 0.796 |
TAO1 |
0.713 | -0.071 | 1 | 0.201 |
CK2A1 |
0.712 | -0.101 | 1 | 0.137 |
TESK1_TYR |
0.711 | 0.064 | 3 | 0.819 |
PKMYT1_TYR |
0.711 | 0.149 | 3 | 0.788 |
ASK1 |
0.711 | -0.104 | 1 | 0.204 |
MEK2 |
0.710 | -0.206 | 2 | 0.787 |
MYO3A |
0.710 | -0.069 | 1 | 0.207 |
TTK |
0.709 | -0.091 | -2 | 0.771 |
PLK2 |
0.709 | -0.091 | -3 | 0.792 |
RIPK2 |
0.707 | -0.244 | 1 | 0.178 |
PDHK4_TYR |
0.707 | 0.039 | 2 | 0.833 |
MAP2K4_TYR |
0.706 | 0.025 | -1 | 0.844 |
MAP2K7_TYR |
0.702 | -0.084 | 2 | 0.819 |
MAP2K6_TYR |
0.702 | -0.005 | -1 | 0.845 |
BMPR2_TYR |
0.700 | -0.008 | -1 | 0.835 |
LIMK1_TYR |
0.700 | 0.011 | 2 | 0.830 |
YANK3 |
0.699 | -0.066 | 2 | 0.380 |
PINK1_TYR |
0.698 | -0.135 | 1 | 0.257 |
PDHK1_TYR |
0.697 | -0.073 | -1 | 0.847 |
RET |
0.697 | -0.128 | 1 | 0.226 |
TNNI3K_TYR |
0.695 | -0.002 | 1 | 0.251 |
MST1R |
0.695 | -0.095 | 3 | 0.752 |
JAK2 |
0.695 | -0.106 | 1 | 0.232 |
NEK10_TYR |
0.694 | -0.076 | 1 | 0.195 |
CSF1R |
0.694 | -0.080 | 3 | 0.736 |
ROS1 |
0.693 | -0.109 | 3 | 0.715 |
JAK1 |
0.693 | -0.054 | 1 | 0.201 |
TYK2 |
0.693 | -0.183 | 1 | 0.212 |
EPHA6 |
0.692 | -0.096 | -1 | 0.798 |
TNK1 |
0.691 | -0.038 | 3 | 0.721 |
TNK2 |
0.691 | -0.071 | 3 | 0.697 |
ABL2 |
0.691 | -0.092 | -1 | 0.757 |
CK1A |
0.690 | -0.064 | -3 | 0.361 |
TYRO3 |
0.689 | -0.152 | 3 | 0.744 |
ALPHAK3 |
0.689 | -0.139 | -1 | 0.729 |
ABL1 |
0.689 | -0.090 | -1 | 0.751 |
STLK3 |
0.689 | -0.190 | 1 | 0.182 |
JAK3 |
0.688 | -0.133 | 1 | 0.218 |
EPHB4 |
0.687 | -0.136 | -1 | 0.765 |
TXK |
0.686 | -0.091 | 1 | 0.174 |
FGR |
0.686 | -0.147 | 1 | 0.191 |
YES1 |
0.686 | -0.112 | -1 | 0.814 |
LCK |
0.685 | -0.086 | -1 | 0.789 |
DDR1 |
0.685 | -0.152 | 4 | 0.747 |
KDR |
0.684 | -0.093 | 3 | 0.688 |
BLK |
0.682 | -0.081 | -1 | 0.790 |
FGFR2 |
0.682 | -0.080 | 3 | 0.715 |
FGFR1 |
0.681 | -0.067 | 3 | 0.688 |
HCK |
0.680 | -0.148 | -1 | 0.785 |
ITK |
0.680 | -0.148 | -1 | 0.751 |
KIT |
0.680 | -0.142 | 3 | 0.733 |
TEK |
0.679 | -0.047 | 3 | 0.669 |
FLT3 |
0.678 | -0.176 | 3 | 0.743 |
WEE1_TYR |
0.678 | -0.083 | -1 | 0.712 |
PDGFRB |
0.678 | -0.209 | 3 | 0.743 |
MET |
0.676 | -0.126 | 3 | 0.722 |
INSRR |
0.675 | -0.183 | 3 | 0.672 |
PDGFRA |
0.675 | -0.199 | 3 | 0.744 |
FER |
0.675 | -0.220 | 1 | 0.195 |
EPHA4 |
0.674 | -0.129 | 2 | 0.708 |
AXL |
0.674 | -0.173 | 3 | 0.708 |
SRMS |
0.674 | -0.198 | 1 | 0.170 |
DDR2 |
0.673 | -0.060 | 3 | 0.657 |
MERTK |
0.672 | -0.166 | 3 | 0.700 |
BMX |
0.672 | -0.129 | -1 | 0.678 |
EPHB1 |
0.671 | -0.208 | 1 | 0.177 |
FYN |
0.670 | -0.101 | -1 | 0.776 |
FGFR3 |
0.670 | -0.102 | 3 | 0.684 |
EPHB3 |
0.670 | -0.196 | -1 | 0.743 |
EPHB2 |
0.668 | -0.190 | -1 | 0.736 |
FLT1 |
0.667 | -0.162 | -1 | 0.767 |
BTK |
0.667 | -0.224 | -1 | 0.723 |
ALK |
0.667 | -0.181 | 3 | 0.642 |
TEC |
0.666 | -0.176 | -1 | 0.685 |
FRK |
0.666 | -0.159 | -1 | 0.782 |
ERBB2 |
0.665 | -0.187 | 1 | 0.190 |
EPHA1 |
0.665 | -0.171 | 3 | 0.705 |
PTK6 |
0.665 | -0.210 | -1 | 0.684 |
YANK2 |
0.665 | -0.086 | 2 | 0.386 |
LTK |
0.664 | -0.193 | 3 | 0.661 |
EPHA7 |
0.664 | -0.160 | 2 | 0.716 |
EGFR |
0.663 | -0.124 | 1 | 0.160 |
PTK2B |
0.663 | -0.126 | -1 | 0.722 |
FLT4 |
0.663 | -0.184 | 3 | 0.676 |
NTRK3 |
0.663 | -0.162 | -1 | 0.712 |
INSR |
0.662 | -0.192 | 3 | 0.658 |
MATK |
0.662 | -0.123 | -1 | 0.686 |
NTRK1 |
0.661 | -0.242 | -1 | 0.757 |
SRC |
0.661 | -0.135 | -1 | 0.770 |
LYN |
0.661 | -0.162 | 3 | 0.655 |
CK1G3 |
0.661 | -0.083 | -3 | 0.310 |
NTRK2 |
0.660 | -0.235 | 3 | 0.684 |
MUSK |
0.660 | -0.140 | 1 | 0.151 |
EPHA3 |
0.659 | -0.183 | 2 | 0.686 |
FGFR4 |
0.656 | -0.128 | -1 | 0.704 |
CSK |
0.656 | -0.163 | 2 | 0.723 |
EPHA8 |
0.656 | -0.149 | -1 | 0.734 |
PTK2 |
0.655 | -0.084 | -1 | 0.744 |
SYK |
0.652 | -0.112 | -1 | 0.720 |
EPHA5 |
0.650 | -0.194 | 2 | 0.686 |
ERBB4 |
0.650 | -0.113 | 1 | 0.156 |
ZAP70 |
0.647 | -0.070 | -1 | 0.658 |
CK1G2 |
0.645 | -0.085 | -3 | 0.404 |
EPHA2 |
0.643 | -0.166 | -1 | 0.699 |
IGF1R |
0.642 | -0.190 | 3 | 0.590 |
FES |
0.630 | -0.179 | -1 | 0.654 |