Motif 221 (n=197)

Position-wise Probabilities

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uniprot genes site source protein function
A8K855 EFCAB7 S212 ochoa EF-hand calcium-binding domain-containing protein 7 Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}.
B8ZZF3 None S309 ochoa Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}.
H0YIS7 RNASEK-C17orf49 S137 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}.
O00192 ARVCF S198 ochoa Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}.
O14497 ARID1A S1352 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O15417 TNRC18 S999 ochoa Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) None
O43187 IRAK2 S144 ochoa Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.
O43281 EFS S319 ochoa Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.
O43281 EFS S323 ochoa Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}.
O43516 WIPF1 S154 ochoa|psp WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
O60292 SIPA1L3 S1685 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75182 SIN3B S740 ochoa Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). {ECO:0000250|UniProtKB:Q62141, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}.
O75376 NCOR1 S2136 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O75962 TRIO S2477 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
O94806 PRKD3 S27 ochoa Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O94806 PRKD3 S31 ochoa Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O95267 RASGRP1 S694 ochoa RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332). {ECO:0000250|UniProtKB:Q9Z1S3, ECO:0000269|PubMed:10807788, ECO:0000269|PubMed:12782630, ECO:0000269|PubMed:12839994, ECO:0000269|PubMed:12845332, ECO:0000269|PubMed:15060167, ECO:0000269|PubMed:15184873, ECO:0000269|PubMed:15899849, ECO:0000269|PubMed:19933860, ECO:0000269|PubMed:23908768, ECO:0000269|PubMed:27776107, ECO:0000269|PubMed:29155103}.
O95382 MAP3K6 S931 ochoa Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.
O95402 MED26 S301 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95644 NFATC1 S290 ochoa Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}.
O95685 PPP1R3D S46 ochoa Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
O95935 TBX18 S117 ochoa T-box transcription factor TBX18 (T-box protein 18) Acts as a transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. {ECO:0000250|UniProtKB:Q9EPZ6, ECO:0000269|PubMed:26235987}.
P05423 POLR3D T21 ochoa DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}.
P06400 RB1 S780 ochoa|psp Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.
P06401 PGR S345 psp Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
P08151 GLI1 S968 psp Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P15408 FOSL2 S211 ochoa Fos-related antigen 2 (FRA-2) Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}.
P17600 SYN1 S551 ochoa Synapsin-1 (Brain protein 4.1) (Synapsin I) Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}.
P19484 TFEB S122 ochoa|psp Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}.
P21359 NF1 S2496 ochoa Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.
P25054 APC S2323 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P29372 MPG S48 ochoa DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
P29536 LMOD1 S516 ochoa Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}.
P29536 LMOD1 S520 ochoa Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen) Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:28292896}.
P32519 ELF1 S376 ochoa ETS-related transcription factor Elf-1 (E74-like factor 1) Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.
P39880 CUX1 S909 ochoa Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.
P40222 TXLNA S19 ochoa Alpha-taxilin May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
P41212 ETV6 S203 ochoa Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.
P42768 WAS S221 ochoa Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}.
P46013 MKI67 S2588 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P48634 PRRC2A S808 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49327 FASN S831 ochoa Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}.
P49418 AMPH S276 psp Amphiphysin May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
P49715 CEBPA S234 psp CCAAT/enhancer-binding protein alpha (C/EBP alpha) Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}.
P49848 TAF6 S634 ochoa Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}.
P51532 SMARCA4 S35 psp SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P53990 IST1 S307 ochoa IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
P55196 AFDN Y1219 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P55317 FOXA1 S331 ochoa Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.
P55317 FOXA1 S355 ochoa Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863, ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809, ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.
P55347 PKNOX1 S47 ochoa Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}.
P78524 DENND2B S88 ochoa DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}.
Q01196 RUNX1 S225 ochoa Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.
Q02224 CENPE S2639 ochoa|psp Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules (PubMed:23891108, PubMed:25395579, PubMed:7889940). The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated (PubMed:25908662). Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends (PubMed:23955301). Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (PubMed:25743205). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:17535814) The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (By similarity). {ECO:0000250|UniProtKB:Q6RT24, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:23955301, ECO:0000269|PubMed:25395579, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:25908662, ECO:0000269|PubMed:7889940}.
Q04726 TLE3 S267 ochoa|psp Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}.
Q06190 PPP2R3A S684 ochoa Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q07912 TNK2 S724 ochoa Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
Q12770 SCAP S943 ochoa Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}.
Q12774 ARHGEF5 S643 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q13191 CBLB S529 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13207 TBX2 S336 ochoa T-box transcription factor TBX2 (T-box protein 2) Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.
Q13428 TCOF1 S1111 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13459 MYO9B S1242 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q13469 NFATC2 S221 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13495 MAMLD1 S455 ochoa Mastermind-like domain-containing protein 1 (F18) (Protein CG1) Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}.
Q14005 IL16 S920 ochoa Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Q14160 SCRIB S1348 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14244 MAP7 S348 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14684 RRP1B S732 ochoa Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}.
Q14687 GSE1 S572 ochoa Genetic suppressor element 1 None
Q15021 NCAPD2 S1330 ochoa Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15365 PCBP1 S190 ochoa Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}.
Q15643 TRIP11 S1882 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q15648 MED1 S1196 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15742 NAB2 S171 ochoa NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}.
Q15942 ZYX S259 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q15942 ZYX S267 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16584 MAP3K11 S793 ochoa|psp Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}.
Q2KHM9 KIAA0753 S568 ochoa Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) Involved in centriole duplication (PubMed:24613305, PubMed:26297806). Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806). Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). May play a role in cilium assembly. {ECO:0000269|PubMed:24613305, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:28220259}.
Q2KJY2 KIF26B S1016 ochoa Kinesin-like protein KIF26B Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.
Q2TAZ0 ATG2A S1309 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q58A45 PAN3 S211 ochoa PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.
Q58A45 PAN3 S354 ochoa PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.
Q5JSZ5 PRRC2B S1789 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5JTC6 AMER1 S430 psp APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}.
Q5M775 SPECC1 S793 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5SV97 PERM1 S156 ochoa PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}.
Q5SYE7 NHSL1 S1292 ochoa NHS-like protein 1 None
Q5TCZ1 SH3PXD2A S572 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q69YH5 CDCA2 S960 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6IBW4 NCAPH2 S232 ochoa Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}.
Q6JBY9 RCSD1 S105 ochoa CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.
Q6NUN9 ZNF746 S404 ochoa Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}.
Q6NXT4 SLC30A6 S388 ochoa Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). {ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:19759014, ECO:0000269|PubMed:35525268}.
Q6P0Q8 MAST2 S1362 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PJG2 MIDEAS S661 ochoa Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1) None
Q6UB99 ANKRD11 S2021 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6WCQ1 MPRIP S360 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZU65 UBN2 S1060 ochoa Ubinuclein-2 None
Q75VX8 GAREM2 S735 ochoa GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. {ECO:0000250}.
Q76L83 ASXL2 S1300 ochoa Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}.
Q76N32 CEP68 S249 ochoa Centrosomal protein of 68 kDa (Cep68) Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}.
Q7RTT9 SLC29A4 S310 ochoa Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4) Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718, PubMed:17018840, PubMed:20592246, PubMed:22396231, PubMed:31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20858707, PubMed:22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718, PubMed:20592246, PubMed:31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:17018840). Also transports guanidine (PubMed:16099839). {ECO:0000250|UniProtKB:Q8R139, ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16099839, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:20592246, ECO:0000269|PubMed:20858707, ECO:0000269|PubMed:22396231, ECO:0000269|PubMed:31537831}.
Q7Z591 AKNA S272 ochoa Microtubule organization protein AKNA (AT-hook-containing transcription factor) Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
Q86UU1 PHLDB1 S157 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86UU1 PHLDB1 S501 ochoa Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) None
Q86VM9 ZC3H18 S852 ochoa Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) None
Q86X27 RALGPS2 S308 ochoa Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q86YV0 RASAL3 S841 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q8IVL1 NAV2 S1302 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IWQ3 BRSK2 S439 ochoa Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.
Q8IX07 ZFPM1 S786 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IX07 ZFPM1 S909 ochoa Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IX21 SLF2 S21 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IXM2 BACC1 S96 ochoa|psp BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Q8IY33 MICALL2 S153 ochoa MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}.
Q8N3F8 MICALL1 S471 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N3F8 MICALL1 S644 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N3V7 SYNPO S787 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N884 CGAS S116 ochoa|psp Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}.
Q8ND30 PPFIBP2 S414 ochoa Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q8NDX1 PSD4 S461 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8NFQ8 TOR1AIP2 S120 ochoa Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1) Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269|PubMed:19339278, ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.
Q8NHM5 KDM2B S1031 ochoa Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:17994099, ECO:0000269|PubMed:26237645, ECO:0000305}.
Q8TC26 TMEM163 S38 ochoa Transmembrane protein 163 Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000269|PubMed:25130899, ECO:0000269|PubMed:31697912, ECO:0000269|PubMed:32492420, ECO:0000269|PubMed:35455965, ECO:0000269|PubMed:36204728}.
Q8TDC3 BRSK1 S508 ochoa Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.
Q8TDM6 DLG5 S1000 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TEM1 NUP210 S1848 ochoa Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.
Q8WUF5 PPP1R13L S567 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WXE0 CASKIN2 S695 ochoa Caskin-2 (CASK-interacting protein 2) None
Q92558 WASF1 S333 ochoa Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}.
Q92574 TSC1 S538 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q92995 USP13 S630 ochoa Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}.
Q93052 LPP Y346 ochoa Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
Q969W9 PMEPA1 S233 ochoa Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein) Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
Q96A73 KIAA1191 S183 ochoa Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa) Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.
Q96B18 DACT3 S348 ochoa Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}.
Q96B97 SH3KBP1 S568 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96D05 FAM241B S28 ochoa Protein FAM241B May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}.
Q96HC4 PDLIM5 S111 ochoa PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}.
Q96JM3 CHAMP1 S325 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96K37 SLC35E1 S94 ochoa Solute carrier family 35 member E1 Putative transporter. {ECO:0000250}.
Q96L91 EP400 S717 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q96MM6 HSPA12B S29 ochoa Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B) None
Q96NA8 TSNARE1 S96 ochoa t-SNARE domain-containing protein 1 None
Q96RT1 ERBIN S1310 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q99638 RAD9A S336 ochoa|psp Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}.
Q99684 GFI1 S98 ochoa|psp Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163) Transcription repressor essential for hematopoiesis (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Functions in a cell-context and development-specific manner (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed:11060035, PubMed:17197705, PubMed:17646546, PubMed:18805794, PubMed:19164764, PubMed:20190815, PubMed:8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed:19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed:29651020). {ECO:0000250|UniProtKB:P70338, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12778173, ECO:0000269|PubMed:16287849, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17646546, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:19026687, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:20190815, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8754800}.
Q99700 ATXN2 S558 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q9BQQ3 GORASP1 S241 ochoa Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.
Q9BUR4 WRAP53 S30 ochoa Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}.
Q9BUT9 MCRIP2 S61 ochoa MAPK regulated corepressor interacting protein 2 (Protein FAM195A) None
Q9BW04 SARG S429 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BWG6 SCNM1 S144 ochoa Sodium channel modifier 1 As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}.
Q9BYX2 TBC1D2 S267 ochoa TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}.
Q9C0B5 ZDHHC5 S321 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0K0 BCL11B S678 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H211 CDT1 S411 ochoa|psp DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H6K5 PRR36 S1107 ochoa Proline-rich protein 36 None
Q9H6K5 PRR36 S1109 ochoa Proline-rich protein 36 None
Q9H6S0 YTHDC2 S1267 ochoa 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}.
Q9H706 GAREM1 S785 ochoa GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
Q9H7N4 SCAF1 S672 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9 PLEKHG2 S450 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9HBL0 TNS1 S708 psp Tensin-1 (EC 3.1.3.-) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}.
Q9HCE9 ANO8 S1013 ochoa Anoctamin-8 (Transmembrane protein 16H) Does not exhibit calcium-activated chloride channel (CaCC) activity.
Q9HCK8 CHD8 S1978 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NP74 PALMD S370 ochoa Palmdelphin (Paralemmin-like protein) None
Q9NQV6 PRDM10 S820 ochoa PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin) Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250|UniProtKB:Q3UTQ7, ECO:0000269|PubMed:36440963}.
Q9NRA0 SPHK2 S387 ochoa|psp Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Q9NRA8 EIF4ENIF1 S568 ochoa Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.
Q9NZC9 SMARCAL1 S112 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}.
Q9NZM4 BICRA S919 ochoa BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}.
Q9P107 GMIP S365 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P1Y5 CAMSAP3 S777 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P266 JCAD S1194 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9UBF8 PI4KB S258 ochoa Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.
Q9UBU9 NXF1 S558 ochoa Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.
Q9UH73 EBF1 S567 ochoa Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:27807034}.; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314). {ECO:0000269|PubMed:26819314, ECO:0000269|PubMed:28968461}.
Q9UI10 EIF2B4 S130 ochoa Translation initiation factor eIF2B subunit delta (eIF2B GDP-GTP exchange factor subunit delta) Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). {ECO:0000269|PubMed:25858979, ECO:0000269|PubMed:27023709, ECO:0000269|PubMed:31048492}.
Q9UIF8 BAZ2B S533 ochoa Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}.
Q9UL51 HCN2 S779 ochoa Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}.
Q9ULH7 MRTFB S209 ochoa Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}.
Q9UNH5 CDC14A S411 psp Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.
Q9UPA5 BSN S252 ochoa Protein bassoon (Zinc finger protein 231) Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.
Q9UPS6 SETD1B S1298 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9UPT8 ZC3H4 S1065 ochoa Zinc finger CCCH domain-containing protein 4 RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}.
Q9UPZ9 CILK1 S584 ochoa Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q62726, ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473, ECO:0000269|PubMed:24853502}.
Q9UQC2 GAB2 S141 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y2F5 ICE1 S1701 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y2H5 PLEKHA6 S854 ochoa Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) None
Q9Y570 PPME1 S25 ochoa Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
P78417 GSTO1 S23 Sugiyama Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. {ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529}.
P19438 TNFRSF1A S274 SIGNOR|iPTMNet Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
O43602 DCX S287 SIGNOR|iPTMNet Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}.
Q15569 TESK1 S353 Sugiyama Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}.
Q09472 EP300 S24 GPS6|ELM|EPSD Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.
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reactome_id name p -log10_p
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.000051 4.293
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.000112 3.952
R-HSA-2025928 Calcineurin activates NFAT 0.000601 3.221
R-HSA-9932444 ATP-dependent chromatin remodelers 0.000861 3.065
R-HSA-9932451 SWI/SNF chromatin remodelers 0.000861 3.065
R-HSA-9843745 Adipogenesis 0.000904 3.044
R-HSA-4839748 Signaling by AMER1 mutants 0.001139 2.943
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 0.001370 2.863
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.001985 2.702
R-HSA-8878171 Transcriptional regulation by RUNX1 0.001926 2.715
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.001912 2.719
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.002227 2.652
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.002480 2.606
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 0.004088 2.389
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 0.004088 2.389
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.004088 2.389
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.003778 2.423
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.004784 2.320
R-HSA-9018519 Estrogen-dependent gene expression 0.004827 2.316
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.005293 2.276
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.007529 2.123
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.013263 1.877
R-HSA-5467343 Deletions in the AMER1 gene destabilize the destruction complex 0.013263 1.877
R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus 0.013263 1.877
R-HSA-4839744 Signaling by APC mutants 0.015383 1.813
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.015383 1.813
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.015383 1.813
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.015383 1.813
R-HSA-5339716 Signaling by GSK3beta mutants 0.017507 1.757
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.019747 1.705
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.019747 1.705
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.019747 1.705
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.019747 1.705
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.019747 1.705
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.019747 1.705
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.022100 1.656
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.022100 1.656
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.012842 1.891
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.011895 1.925
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.011895 1.925
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.021318 1.671
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.011895 1.925
R-HSA-8951936 RUNX3 regulates p14-ARF 0.019747 1.705
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.019747 1.705
R-HSA-4791275 Signaling by WNT in cancer 0.014815 1.829
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.009375 2.028
R-HSA-9930044 Nuclear RNA decay 0.015862 1.800
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.008886 2.051
R-HSA-4839735 Signaling by AXIN mutants 0.017507 1.757
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.022100 1.656
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.018079 1.743
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.021710 1.663
R-HSA-9682385 FLT3 signaling in disease 0.020459 1.689
R-HSA-212165 Epigenetic regulation of gene expression 0.017836 1.749
R-HSA-8878159 Transcriptional regulation by RUNX3 0.015610 1.807
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.013380 1.874
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.021318 1.671
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.008127 2.090
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 0.022100 1.656
R-HSA-4839726 Chromatin organization 0.010819 1.966
R-HSA-163765 ChREBP activates metabolic gene expression 0.015383 1.813
R-HSA-193648 NRAGE signals death through JNK 0.011140 1.953
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.024336 1.614
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.024563 1.610
R-HSA-1251985 Nuclear signaling by ERBB4 0.025711 1.590
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.024050 1.619
R-HSA-196299 Beta-catenin phosphorylation cascade 0.027133 1.567
R-HSA-383280 Nuclear Receptor transcription pathway 0.029056 1.537
R-HSA-446353 Cell-extracellular matrix interactions 0.027133 1.567
R-HSA-1980143 Signaling by NOTCH1 0.026985 1.569
R-HSA-195721 Signaling by WNT 0.028223 1.549
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.028009 1.553
R-HSA-416482 G alpha (12/13) signalling events 0.029056 1.537
R-HSA-9945266 Differentiation of T cells 0.029805 1.526
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.029805 1.526
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.029805 1.526
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.030079 1.522
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.030126 1.521
R-HSA-9006931 Signaling by Nuclear Receptors 0.034302 1.465
R-HSA-162582 Signal Transduction 0.032981 1.482
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.032334 1.490
R-HSA-9707564 Cytoprotection by HMOX1 0.034635 1.460
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.038412 1.416
R-HSA-9031628 NGF-stimulated transcription 0.039910 1.399
R-HSA-449836 Other interleukin signaling 0.041467 1.382
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.052011 1.284
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.052011 1.284
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.052011 1.284
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.052011 1.284
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.052011 1.284
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.052011 1.284
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.052011 1.284
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.052011 1.284
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.052011 1.284
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.052011 1.284
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.052011 1.284
R-HSA-350054 Notch-HLH transcription pathway 0.054539 1.263
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.047838 1.320
R-HSA-8939211 ESR-mediated signaling 0.058611 1.232
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.059427 1.226
R-HSA-201681 TCF dependent signaling in response to WNT 0.055327 1.257
R-HSA-3247509 Chromatin modifying enzymes 0.055759 1.254
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.051149 1.291
R-HSA-9671555 Signaling by PDGFR in disease 0.051149 1.291
R-HSA-193704 p75 NTR receptor-mediated signalling 0.061133 1.214
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.063780 1.195
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.063780 1.195
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.063780 1.195
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.063780 1.195
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.063780 1.195
R-HSA-8941237 Invadopodia formation 0.064588 1.190
R-HSA-1296061 HCN channels 0.076998 1.114
R-HSA-5626978 TNFR1-mediated ceramide production 0.076998 1.114
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.076998 1.114
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.076998 1.114
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.089245 1.049
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.101330 0.994
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.101330 0.994
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.101330 0.994
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.113255 0.946
R-HSA-9645135 STAT5 Activation 0.113255 0.946
R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.113255 0.946
R-HSA-72731 Recycling of eIF2:GDP 0.125022 0.903
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.136635 0.864
R-HSA-1169092 Activation of RAS in B cells 0.136635 0.864
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.148093 0.829
R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.148093 0.829
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.181569 0.741
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.203156 0.692
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.203156 0.692
R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.213736 0.670
R-HSA-73780 RNA Polymerase III Chain Elongation 0.224176 0.649
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.096368 1.016
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.100522 0.998
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.234478 0.630
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.126406 0.898
R-HSA-73980 RNA Polymerase III Transcription Termination 0.264574 0.577
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.130862 0.883
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.302878 0.519
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.302878 0.519
R-HSA-5658442 Regulation of RAS by GAPs 0.181887 0.740
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.356642 0.448
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.230340 0.638
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.373629 0.428
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.381955 0.418
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.381955 0.418
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.390170 0.409
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.390170 0.409
R-HSA-1855170 IPs transport between nucleus and cytosol 0.406277 0.391
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.294257 0.531
R-HSA-1989781 PPARA activates gene expression 0.201888 0.695
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.338169 0.471
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.086984 1.061
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.068845 1.162
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.203156 0.692
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.084222 1.075
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.125022 0.903
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.406277 0.391
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.203156 0.692
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.362223 0.441
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocy... 0.136635 0.864
R-HSA-3928663 EPHA-mediated growth cone collapse 0.356642 0.448
R-HSA-4641265 Repression of WNT target genes 0.192434 0.716
R-HSA-2299718 Condensation of Prophase Chromosomes 0.162966 0.788
R-HSA-171319 Telomere Extension By Telomerase 0.365192 0.437
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.181569 0.741
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.406277 0.391
R-HSA-9675126 Diseases of mitotic cell cycle 0.398277 0.400
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.181569 0.741
R-HSA-9012852 Signaling by NOTCH3 0.205955 0.686
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.076998 1.114
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.076998 1.114
R-HSA-8866376 Reelin signalling pathway 0.089245 1.049
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.181569 0.741
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.192434 0.716
R-HSA-9796292 Formation of axial mesoderm 0.203156 0.692
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.264574 0.577
R-HSA-113510 E2F mediated regulation of DNA replication 0.274342 0.562
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.302878 0.519
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.312139 0.506
R-HSA-912526 Interleukin receptor SHC signaling 0.321278 0.493
R-HSA-1839124 FGFR1 mutant receptor activation 0.096368 1.016
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.381955 0.418
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.192434 0.716
R-HSA-9664417 Leishmania phagocytosis 0.159799 0.796
R-HSA-9664407 Parasite infection 0.159799 0.796
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.159799 0.796
R-HSA-5655302 Signaling by FGFR1 in disease 0.139880 0.854
R-HSA-9620244 Long-term potentiation 0.339195 0.470
R-HSA-418885 DCC mediated attractive signaling 0.224176 0.649
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.162328 0.790
R-HSA-68875 Mitotic Prophase 0.106155 0.974
R-HSA-1980145 Signaling by NOTCH2 0.104725 0.980
R-HSA-182971 EGFR downregulation 0.390170 0.409
R-HSA-5632684 Hedgehog 'on' state 0.090196 1.045
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.381955 0.418
R-HSA-9707616 Heme signaling 0.068276 1.166
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.312139 0.506
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.312139 0.506
R-HSA-9013694 Signaling by NOTCH4 0.299164 0.524
R-HSA-5619507 Activation of HOX genes during differentiation 0.203076 0.692
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.203076 0.692
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.092793 1.032
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.330296 0.481
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.406277 0.391
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.181569 0.741
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.254675 0.594
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.264574 0.577
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.293492 0.532
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.293492 0.532
R-HSA-68962 Activation of the pre-replicative complex 0.381955 0.418
R-HSA-157118 Signaling by NOTCH 0.268350 0.571
R-HSA-68886 M Phase 0.294091 0.532
R-HSA-9711123 Cellular response to chemical stress 0.189603 0.722
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.330296 0.481
R-HSA-6811438 Intra-Golgi traffic 0.139880 0.854
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 0.398277 0.400
R-HSA-5358351 Signaling by Hedgehog 0.342214 0.466
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.092793 1.032
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.113255 0.946
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.072595 1.139
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.244644 0.611
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.381955 0.418
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.406277 0.391
R-HSA-2682334 EPH-Ephrin signaling 0.395330 0.403
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.244644 0.611
R-HSA-9909396 Circadian clock 0.137731 0.861
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.264574 0.577
R-HSA-73887 Death Receptor Signaling 0.082270 1.085
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.148093 0.829
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.203156 0.692
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.224176 0.649
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.302878 0.519
R-HSA-429947 Deadenylation of mRNA 0.330296 0.481
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.216820 0.664
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.088587 1.053
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.258413 0.588
R-HSA-74160 Gene expression (Transcription) 0.336618 0.473
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.373629 0.428
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.100522 0.998
R-HSA-73857 RNA Polymerase II Transcription 0.352200 0.453
R-HSA-983189 Kinesins 0.230340 0.638
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.365192 0.437
R-HSA-212436 Generic Transcription Pathway 0.276118 0.559
R-HSA-3371556 Cellular response to heat stress 0.269813 0.569
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.089245 1.049
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.101330 0.994
R-HSA-9697154 Disorders of Nervous System Development 0.192434 0.716
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.192434 0.716
R-HSA-9005895 Pervasive developmental disorders 0.192434 0.716
R-HSA-9733458 Induction of Cell-Cell Fusion 0.234478 0.630
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.264574 0.577
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.302878 0.519
R-HSA-6802957 Oncogenic MAPK signaling 0.129187 0.889
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.244644 0.611
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.330296 0.481
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.347976 0.458
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.248390 0.605
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.158294 0.801
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.213736 0.670
R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 0.224176 0.649
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.234478 0.630
R-HSA-9675151 Disorders of Developmental Biology 0.244644 0.611
R-HSA-6807004 Negative regulation of MET activity 0.283981 0.547
R-HSA-5689901 Metalloprotease DUBs 0.347976 0.458
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.230340 0.638
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.240150 0.620
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.201112 0.697
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.302878 0.519
R-HSA-1236394 Signaling by ERBB4 0.098080 1.008
R-HSA-1226099 Signaling by FGFR in disease 0.299164 0.524
R-HSA-69206 G1/S Transition 0.287821 0.541
R-HSA-69278 Cell Cycle, Mitotic 0.096558 1.015
R-HSA-447043 Neurofascin interactions 0.113255 0.946
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.224176 0.649
R-HSA-392517 Rap1 signalling 0.274342 0.562
R-HSA-8854214 TBC/RABGAPs 0.149029 0.827
R-HSA-8863795 Downregulation of ERBB2 signaling 0.381955 0.418
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.269667 0.569
R-HSA-199991 Membrane Trafficking 0.403446 0.394
R-HSA-1640170 Cell Cycle 0.111791 0.952
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.298672 0.525
R-HSA-3214858 RMTs methylate histone arginines 0.153647 0.813
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.150571 0.822
R-HSA-156711 Polo-like kinase mediated events 0.264574 0.577
R-HSA-9839394 TGFBR3 expression 0.339195 0.470
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma ... 0.356642 0.448
R-HSA-5687128 MAPK6/MAPK4 signaling 0.352638 0.453
R-HSA-5633007 Regulation of TP53 Activity 0.215671 0.666
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.070577 1.151
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.374770 0.426
R-HSA-8983432 Interleukin-15 signaling 0.192434 0.716
R-HSA-9819196 Zygotic genome activation (ZGA) 0.293492 0.532
R-HSA-3214842 HDMs demethylate histones 0.339195 0.470
R-HSA-9007101 Rab regulation of trafficking 0.255503 0.593
R-HSA-1266738 Developmental Biology 0.139084 0.857
R-HSA-73884 Base Excision Repair 0.381231 0.419
R-HSA-5635838 Activation of SMO 0.234478 0.630
R-HSA-196836 Vitamin C (ascorbate) metabolism 0.293492 0.532
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.398277 0.400
R-HSA-176187 Activation of ATR in response to replication stress 0.406277 0.391
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.177531 0.751
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.087630 1.057
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.234261 0.630
R-HSA-1834941 STING mediated induction of host immune responses 0.274342 0.562
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.335624 0.474
R-HSA-9842663 Signaling by LTK 0.192434 0.716
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.203156 0.692
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.220557 0.656
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.284430 0.546
R-HSA-453276 Regulation of mitotic cell cycle 0.284430 0.546
R-HSA-5683057 MAPK family signaling cascades 0.221516 0.655
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.210812 0.676
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.373629 0.428
R-HSA-5673001 RAF/MAP kinase cascade 0.395923 0.402
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.224176 0.649
R-HSA-166520 Signaling by NTRKs 0.381968 0.418
R-HSA-1592230 Mitochondrial biogenesis 0.099869 1.001
R-HSA-9833109 Evasion by RSV of host interferon responses 0.390170 0.409
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.284430 0.546
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.087630 1.057
R-HSA-5669034 TNFs bind their physiological receptors 0.330296 0.481
R-HSA-9659379 Sensory processing of sound 0.323605 0.490
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.362223 0.441
R-HSA-9833110 RSV-host interactions 0.203076 0.692
R-HSA-446728 Cell junction organization 0.210065 0.678
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.144031 0.842
R-HSA-69205 G1/S-Specific Transcription 0.113270 0.946
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.312139 0.506
R-HSA-9022692 Regulation of MECP2 expression and activity 0.406277 0.391
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.176269 0.754
R-HSA-9793380 Formation of paraxial mesoderm 0.235242 0.628
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.191467 0.718
R-HSA-6783783 Interleukin-10 signaling 0.318732 0.497
R-HSA-1500931 Cell-Cell communication 0.293765 0.532
R-HSA-9692914 SARS-CoV-1-host interactions 0.209922 0.678
R-HSA-6794362 Protein-protein interactions at synapses 0.352638 0.453
R-HSA-9730414 MITF-M-regulated melanocyte development 0.094018 1.027
R-HSA-5621481 C-type lectin receptors (CLRs) 0.249721 0.603
R-HSA-418990 Adherens junctions interactions 0.392798 0.406
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.347976 0.458
R-HSA-9856651 MITF-M-dependent gene expression 0.188383 0.725
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.203156 0.692
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.135354 0.869
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.254675 0.594
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.172992 0.762
R-HSA-354192 Integrin signaling 0.406277 0.391
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.213736 0.670
R-HSA-1266695 Interleukin-7 signaling 0.339195 0.470
R-HSA-186712 Regulation of beta-cell development 0.225444 0.647
R-HSA-9758941 Gastrulation 0.385560 0.414
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.274342 0.562
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.395330 0.403
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.406277 0.391
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.254899 0.594
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.398277 0.400
R-HSA-9678108 SARS-CoV-1 Infection 0.261324 0.583
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.338586 0.470
R-HSA-9020591 Interleukin-12 signaling 0.308961 0.510
R-HSA-447115 Interleukin-12 family signaling 0.366996 0.435
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.414170 0.383
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.414170 0.383
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.414170 0.383
R-HSA-114508 Effects of PIP2 hydrolysis 0.414170 0.383
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.414170 0.383
R-HSA-5684996 MAPK1/MAPK3 signaling 0.414300 0.383
R-HSA-9675108 Nervous system development 0.414689 0.382
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.418494 0.378
R-HSA-180746 Nuclear import of Rev protein 0.421960 0.375
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.421960 0.375
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.421960 0.375
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.421960 0.375
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.421960 0.375
R-HSA-5673000 RAF activation 0.421960 0.375
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.421960 0.375
R-HSA-168638 NOD1/2 Signaling Pathway 0.421960 0.375
R-HSA-9006936 Signaling by TGFB family members 0.424707 0.372
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.429646 0.367
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.429646 0.367
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.429646 0.367
R-HSA-2559585 Oncogene Induced Senescence 0.429646 0.367
R-HSA-3214847 HATs acetylate histones 0.432177 0.364
R-HSA-5610787 Hedgehog 'off' state 0.436701 0.360
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.437230 0.359
R-HSA-74158 RNA Polymerase III Transcription 0.437230 0.359
R-HSA-8853659 RET signaling 0.437230 0.359
R-HSA-8941326 RUNX2 regulates bone development 0.437230 0.359
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.444714 0.352
R-HSA-110331 Cleavage of the damaged purine 0.444714 0.352
R-HSA-933541 TRAF6 mediated IRF7 activation 0.444714 0.352
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.444714 0.352
R-HSA-549127 SLC-mediated transport of organic cations 0.444714 0.352
R-HSA-5689896 Ovarian tumor domain proteases 0.444714 0.352
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.445688 0.351
R-HSA-9842860 Regulation of endogenous retroelements 0.445688 0.351
R-HSA-1483255 PI Metabolism 0.445688 0.351
R-HSA-73927 Depurination 0.452099 0.345
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.452099 0.345
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.452099 0.345
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.459386 0.338
R-HSA-201556 Signaling by ALK 0.459386 0.338
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.466577 0.331
R-HSA-177243 Interactions of Rev with host cellular proteins 0.466577 0.331
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.466577 0.331
R-HSA-3371568 Attenuation phase 0.466577 0.331
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.466577 0.331
R-HSA-451927 Interleukin-2 family signaling 0.466577 0.331
R-HSA-202433 Generation of second messenger molecules 0.466577 0.331
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.473224 0.325
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.473224 0.325
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.473672 0.325
R-HSA-9607240 FLT3 Signaling 0.473672 0.325
R-HSA-3214841 PKMTs methylate histone lysines 0.473672 0.325
R-HSA-9694548 Maturation of spike protein 0.473672 0.325
R-HSA-1852241 Organelle biogenesis and maintenance 0.476469 0.322
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.480007 0.319
R-HSA-167161 HIV Transcription Initiation 0.480674 0.318
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.480674 0.318
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.480674 0.318
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.480674 0.318
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.480674 0.318
R-HSA-165159 MTOR signalling 0.487583 0.312
R-HSA-110329 Cleavage of the damaged pyrimidine 0.487583 0.312
R-HSA-73928 Depyrimidination 0.487583 0.312
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.487583 0.312
R-HSA-421270 Cell-cell junction organization 0.489771 0.310
R-HSA-73776 RNA Polymerase II Promoter Escape 0.494400 0.306
R-HSA-1433557 Signaling by SCF-KIT 0.494400 0.306
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.494400 0.306
R-HSA-449147 Signaling by Interleukins 0.495774 0.305
R-HSA-69236 G1 Phase 0.501127 0.300
R-HSA-69231 Cyclin D associated events in G1 0.501127 0.300
R-HSA-373752 Netrin-1 signaling 0.501127 0.300
R-HSA-3928662 EPHB-mediated forward signaling 0.501127 0.300
R-HSA-156581 Methylation 0.501127 0.300
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.501127 0.300
R-HSA-5688426 Deubiquitination 0.501133 0.300
R-HSA-9679506 SARS-CoV Infections 0.504884 0.297
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.507765 0.294
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.507765 0.294
R-HSA-4608870 Asymmetric localization of PCP proteins 0.507765 0.294
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.507765 0.294
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.510419 0.292
R-HSA-5357905 Regulation of TNFR1 signaling 0.514315 0.289
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.514315 0.289
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.514315 0.289
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.514315 0.289
R-HSA-9649948 Signaling downstream of RAS mutants 0.514315 0.289
R-HSA-6802949 Signaling by RAS mutants 0.514315 0.289
R-HSA-9839373 Signaling by TGFBR3 0.514315 0.289
R-HSA-9675135 Diseases of DNA repair 0.514315 0.289
R-HSA-75153 Apoptotic execution phase 0.514315 0.289
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.514557 0.289
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.520778 0.283
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.520778 0.283
R-HSA-5620924 Intraflagellar transport 0.527156 0.278
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.527156 0.278
R-HSA-8878166 Transcriptional regulation by RUNX2 0.530878 0.275
R-HSA-109704 PI3K Cascade 0.539659 0.268
R-HSA-3371571 HSF1-dependent transactivation 0.545787 0.263
R-HSA-9864848 Complex IV assembly 0.545787 0.263
R-HSA-9694516 SARS-CoV-2 Infection 0.548470 0.261
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.548566 0.261
R-HSA-68949 Orc1 removal from chromatin 0.551833 0.258
R-HSA-6794361 Neurexins and neuroligins 0.551833 0.258
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.557799 0.254
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.557799 0.254
R-HSA-445355 Smooth Muscle Contraction 0.557799 0.254
R-HSA-8948751 Regulation of PTEN stability and activity 0.557799 0.254
R-HSA-194138 Signaling by VEGF 0.558534 0.253
R-HSA-3214815 HDACs deacetylate histones 0.569495 0.245
R-HSA-9658195 Leishmania infection 0.572068 0.243
R-HSA-9824443 Parasitic Infection Pathways 0.572068 0.243
R-HSA-75893 TNF signaling 0.575228 0.240
R-HSA-177929 Signaling by EGFR 0.575228 0.240
R-HSA-2980766 Nuclear Envelope Breakdown 0.580884 0.236
R-HSA-112399 IRS-mediated signalling 0.580884 0.236
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.580884 0.236
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.586465 0.232
R-HSA-8856688 Golgi-to-ER retrograde transport 0.588701 0.230
R-HSA-191859 snRNP Assembly 0.591972 0.228
R-HSA-194441 Metabolism of non-coding RNA 0.591972 0.228
R-HSA-180786 Extension of Telomeres 0.591972 0.228
R-HSA-429914 Deadenylation-dependent mRNA decay 0.591972 0.228
R-HSA-1227986 Signaling by ERBB2 0.597406 0.224
R-HSA-156590 Glutathione conjugation 0.597406 0.224
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.597406 0.224
R-HSA-168325 Viral Messenger RNA Synthesis 0.602769 0.220
R-HSA-2428928 IRS-related events triggered by IGF1R 0.602769 0.220
R-HSA-450294 MAP kinase activation 0.602769 0.220
R-HSA-3858494 Beta-catenin independent WNT signaling 0.606770 0.217
R-HSA-163685 Integration of energy metabolism 0.606770 0.217
R-HSA-6784531 tRNA processing in the nucleus 0.608060 0.216
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.608060 0.216
R-HSA-2428924 IGF1R signaling cascade 0.618432 0.209
R-HSA-74751 Insulin receptor signalling cascade 0.618432 0.209
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.618432 0.209
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.623516 0.205
R-HSA-1234174 Cellular response to hypoxia 0.623516 0.205
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.623516 0.205
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.628532 0.202
R-HSA-162599 Late Phase of HIV Life Cycle 0.631049 0.200
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.631049 0.200
R-HSA-3700989 Transcriptional Regulation by TP53 0.632668 0.199
R-HSA-422475 Axon guidance 0.633364 0.198
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.633481 0.198
R-HSA-8856828 Clathrin-mediated endocytosis 0.634421 0.198
R-HSA-167172 Transcription of the HIV genome 0.638365 0.195
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.638365 0.195
R-HSA-204005 COPII-mediated vesicle transport 0.647939 0.188
R-HSA-75105 Fatty acyl-CoA biosynthesis 0.647939 0.188
R-HSA-69202 Cyclin E associated events during G1/S transition 0.647939 0.188
R-HSA-448424 Interleukin-17 signaling 0.647939 0.188
R-HSA-69242 S Phase 0.650922 0.186
R-HSA-427413 NoRC negatively regulates rRNA expression 0.652631 0.185
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.652631 0.185
R-HSA-5578749 Transcriptional regulation by small RNAs 0.657261 0.182
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.657261 0.182
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.660536 0.180
R-HSA-69052 Switching of origins to a post-replicative state 0.661829 0.179
R-HSA-4086398 Ca2+ pathway 0.661829 0.179
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.666337 0.176
R-HSA-69473 G2/M DNA damage checkpoint 0.666337 0.176
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.666337 0.176
R-HSA-1169408 ISG15 antiviral mechanism 0.670785 0.173
R-HSA-5653656 Vesicle-mediated transport 0.672750 0.172
R-HSA-5689603 UCH proteinases 0.675174 0.171
R-HSA-8957322 Metabolism of steroids 0.675952 0.170
R-HSA-162587 HIV Life Cycle 0.679129 0.168
R-HSA-9694635 Translation of Structural Proteins 0.679505 0.168
R-HSA-4086400 PCP/CE pathway 0.683778 0.165
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.692155 0.160
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.692155 0.160
R-HSA-6806834 Signaling by MET 0.692155 0.160
R-HSA-5693607 Processing of DNA double-strand break ends 0.696260 0.157
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.704308 0.152
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.708252 0.150
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.715984 0.145
R-HSA-141424 Amplification of signal from the kinetochores 0.715984 0.145
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.715984 0.145
R-HSA-438064 Post NMDA receptor activation events 0.723511 0.141
R-HSA-390466 Chaperonin-mediated protein folding 0.723511 0.141
R-HSA-9734767 Developmental Cell Lineages 0.730182 0.137
R-HSA-416476 G alpha (q) signalling events 0.732365 0.135
R-HSA-112310 Neurotransmitter release cycle 0.734432 0.134
R-HSA-8986944 Transcriptional Regulation by MECP2 0.737976 0.132
R-HSA-391251 Protein folding 0.744923 0.128
R-HSA-74752 Signaling by Insulin receptor 0.744923 0.128
R-HSA-2559583 Cellular Senescence 0.745341 0.128
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.748327 0.126
R-HSA-68867 Assembly of the pre-replicative complex 0.748327 0.126
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.751687 0.124
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.755002 0.122
R-HSA-69275 G2/M Transition 0.759957 0.119
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.761499 0.118
R-HSA-6807878 COPI-mediated anterograde transport 0.761499 0.118
R-HSA-1296071 Potassium Channels 0.761499 0.118
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.763481 0.117
R-HSA-453274 Mitotic G2-G2/M phases 0.764666 0.117
R-HSA-157579 Telomere Maintenance 0.764684 0.117
R-HSA-8957275 Post-translational protein phosphorylation 0.767826 0.115
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.767826 0.115
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.767826 0.115
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.767826 0.115
R-HSA-9614085 FOXO-mediated transcription 0.770926 0.113
R-HSA-69618 Mitotic Spindle Checkpoint 0.773985 0.111
R-HSA-70171 Glycolysis 0.773985 0.111
R-HSA-68877 Mitotic Prometaphase 0.776091 0.110
R-HSA-9020702 Interleukin-1 signaling 0.777003 0.110
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.779981 0.108
R-HSA-9609690 HCMV Early Events 0.782711 0.106
R-HSA-112316 Neuronal System 0.783845 0.106
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.785820 0.105
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.791504 0.102
R-HSA-428157 Sphingolipid metabolism 0.793366 0.101
R-HSA-69239 Synthesis of DNA 0.797038 0.099
R-HSA-211000 Gene Silencing by RNA 0.797038 0.099
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.797038 0.099
R-HSA-9700206 Signaling by ALK in cancer 0.797038 0.099
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.799749 0.097
R-HSA-2672351 Stimuli-sensing channels 0.799749 0.097
R-HSA-69002 DNA Replication Pre-Initiation 0.802425 0.096
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.802425 0.096
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.802425 0.096
R-HSA-168249 Innate Immune System 0.804972 0.094
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.805065 0.094
R-HSA-166166 MyD88-independent TLR4 cascade 0.805065 0.094
R-HSA-202403 TCR signaling 0.805065 0.094
R-HSA-1483249 Inositol phosphate metabolism 0.810241 0.091
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.812777 0.090
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.815280 0.089
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.817749 0.087
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.820185 0.086
R-HSA-68882 Mitotic Anaphase 0.824430 0.084
R-HSA-2262752 Cellular responses to stress 0.824524 0.084
R-HSA-72737 Cap-dependent Translation Initiation 0.824961 0.084
R-HSA-72613 Eukaryotic Translation Initiation 0.824961 0.084
R-HSA-373760 L1CAM interactions 0.824961 0.084
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.826225 0.083
R-HSA-70326 Glucose metabolism 0.827301 0.082
R-HSA-5693538 Homology Directed Repair 0.829610 0.081
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.829610 0.081
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.831889 0.080
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.831889 0.080
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.836355 0.078
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.836355 0.078
R-HSA-73886 Chromosome Maintenance 0.836355 0.078
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.838544 0.076
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.838544 0.076
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.840703 0.075
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.840703 0.075
R-HSA-2132295 MHC class II antigen presentation 0.840703 0.075
R-HSA-162909 Host Interactions of HIV factors 0.842834 0.074
R-HSA-162906 HIV Infection 0.843296 0.074
R-HSA-9705683 SARS-CoV-2-host interactions 0.844917 0.073
R-HSA-9824446 Viral Infection Pathways 0.845639 0.073
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.848113 0.072
R-HSA-69481 G2/M Checkpoints 0.851077 0.070
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.856976 0.067
R-HSA-6807070 PTEN Regulation 0.876683 0.057
R-HSA-9609646 HCMV Infection 0.876942 0.057
R-HSA-1632852 Macroautophagy 0.879964 0.056
R-HSA-73894 DNA Repair 0.884347 0.053
R-HSA-2871837 FCERI mediated NF-kB activation 0.886267 0.052
R-HSA-69620 Cell Cycle Checkpoints 0.886997 0.052
R-HSA-199977 ER to Golgi Anterograde Transport 0.890778 0.050
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.892241 0.050
R-HSA-9679191 Potential therapeutics for SARS 0.895110 0.048
R-HSA-446652 Interleukin-1 family signaling 0.897903 0.047
R-HSA-69306 DNA Replication 0.899271 0.046
R-HSA-5693532 DNA Double-Strand Break Repair 0.899271 0.046
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.900621 0.045
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.901954 0.045
R-HSA-9612973 Autophagy 0.903268 0.044
R-HSA-9610379 HCMV Late Events 0.904565 0.044
R-HSA-109581 Apoptosis 0.910794 0.041
R-HSA-2467813 Separation of Sister Chromatids 0.913171 0.039
R-HSA-8953897 Cellular responses to stimuli 0.914800 0.039
R-HSA-5619102 SLC transporter disorders 0.916619 0.038
R-HSA-72306 tRNA processing 0.921005 0.036
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.923111 0.035
R-HSA-1280215 Cytokine Signaling in Immune system 0.924121 0.034
R-HSA-5689880 Ub-specific processing proteases 0.924143 0.034
R-HSA-1257604 PIP3 activates AKT signaling 0.924352 0.034
R-HSA-1483257 Phospholipid metabolism 0.924352 0.034
R-HSA-611105 Respiratory electron transport 0.929099 0.032
R-HSA-168255 Influenza Infection 0.930051 0.031
R-HSA-983712 Ion channel transport 0.938898 0.027
R-HSA-5617833 Cilium Assembly 0.939719 0.027
R-HSA-168898 Toll-like Receptor Cascades 0.940529 0.027
R-HSA-1643685 Disease 0.941455 0.026
R-HSA-8953854 Metabolism of RNA 0.942246 0.026
R-HSA-72163 mRNA Splicing - Major Pathway 0.942895 0.026
R-HSA-112315 Transmission across Chemical Synapses 0.944548 0.025
R-HSA-389948 Co-inhibition by PD-1 0.947348 0.023
R-HSA-948021 Transport to the Golgi and subsequent modification 0.948755 0.023
R-HSA-376176 Signaling by ROBO receptors 0.949444 0.023
R-HSA-1280218 Adaptive Immune System 0.950713 0.022
R-HSA-72172 mRNA Splicing 0.950794 0.022
R-HSA-5357801 Programmed Cell Death 0.951456 0.022
R-HSA-5663205 Infectious disease 0.954146 0.020
R-HSA-9006925 Intracellular signaling by second messengers 0.955219 0.020
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.955847 0.020
R-HSA-397014 Muscle contraction 0.955847 0.020
R-HSA-8951664 Neddylation 0.960916 0.017
R-HSA-196854 Metabolism of vitamins and cofactors 0.965132 0.015
R-HSA-156580 Phase II - Conjugation of compounds 0.969382 0.014
R-HSA-5619115 Disorders of transmembrane transporters 0.972532 0.012
R-HSA-388841 Regulation of T cell activation by CD28 family 0.975693 0.011
R-HSA-425407 SLC-mediated transmembrane transport 0.976438 0.010
R-HSA-76002 Platelet activation, signaling and aggregation 0.980968 0.008
R-HSA-388396 GPCR downstream signalling 0.982531 0.008
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.982930 0.007
R-HSA-556833 Metabolism of lipids 0.984218 0.007
R-HSA-168256 Immune System 0.986320 0.006
R-HSA-6798695 Neutrophil degranulation 0.988363 0.005
R-HSA-1474244 Extracellular matrix organization 0.991246 0.004
R-HSA-372790 Signaling by GPCR 0.992083 0.003
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.992363 0.003
R-HSA-109582 Hemostasis 0.994890 0.002
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.995759 0.002
R-HSA-913531 Interferon Signaling 0.995759 0.002
R-HSA-9824439 Bacterial Infection Pathways 0.996146 0.002
R-HSA-8978868 Fatty acid metabolism 0.996947 0.001
R-HSA-446203 Asparagine N-linked glycosylation 0.997515 0.001
R-HSA-72766 Translation 0.997743 0.001
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.998421 0.001
R-HSA-211859 Biological oxidations 0.999382 0.000
R-HSA-597592 Post-translational protein modification 0.999748 0.000
R-HSA-382551 Transport of small molecules 0.999883 0.000
R-HSA-9752946 Expression and translocation of olfactory receptors 0.999985 0.000
R-HSA-381753 Olfactory Signaling Pathway 0.999995 0.000
R-HSA-9709957 Sensory Perception 0.999995 0.000
R-HSA-392499 Metabolism of proteins 0.999999 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.789 0.531 1 0.917
KISKIS 0.789 0.526 1 0.876
CDK18CDK18 0.789 0.600 1 0.907
CDK17CDK17 0.780 0.588 1 0.916
CDK19CDK19 0.779 0.548 1 0.898
CDK3CDK3 0.779 0.512 1 0.919
CDK1CDK1 0.777 0.550 1 0.902
P38GP38G 0.775 0.566 1 0.925
CDK5CDK5 0.773 0.556 1 0.870
CDK8CDK8 0.772 0.538 1 0.879
CDK13CDK13 0.771 0.548 1 0.900
DYRK2DYRK2 0.771 0.505 1 0.874
CDK7CDK7 0.771 0.562 1 0.889
ERK1ERK1 0.770 0.560 1 0.909
P38DP38D 0.770 0.555 1 0.935
P38BP38B 0.770 0.572 1 0.901
CLK3CLK3 0.769 0.397 1 0.665
CDK12CDK12 0.769 0.542 1 0.910
JNK2JNK2 0.768 0.564 1 0.914
CDK16CDK16 0.768 0.549 1 0.910
HIPK4HIPK4 0.767 0.400 1 0.707
HIPK1HIPK1 0.766 0.475 1 0.854
DYRK4DYRK4 0.766 0.509 1 0.926
CDK10CDK10 0.763 0.486 1 0.895
JNK3JNK3 0.762 0.553 1 0.901
CDK9CDK9 0.762 0.526 1 0.897
CDK14CDK14 0.759 0.527 1 0.884
MAKMAK 0.758 0.413 -2 0.809
SRPK1SRPK1 0.758 0.220 -3 0.166
DYRK1BDYRK1B 0.757 0.475 1 0.885
P38AP38A 0.756 0.535 1 0.858
CLK2CLK2 0.754 0.269 -3 0.153
HIPK3HIPK3 0.750 0.443 1 0.825
DYRK1ADYRK1A 0.749 0.381 1 0.827
NLKNLK 0.749 0.478 1 0.701
ERK5ERK5 0.748 0.362 1 0.640
ERK2ERK2 0.747 0.525 1 0.873
SRPK2SRPK2 0.746 0.155 -3 0.128
JNK1JNK1 0.746 0.499 1 0.907
CDK6CDK6 0.744 0.496 1 0.892
CLK1CLK1 0.743 0.244 -3 0.136
CDK4CDK4 0.742 0.507 1 0.913
DYRK3DYRK3 0.741 0.335 1 0.829
MTORMTOR 0.740 0.214 1 0.505
CLK4CLK4 0.739 0.226 -3 0.142
CDKL5CDKL5 0.736 0.115 -3 0.195
CDK2CDK2 0.735 0.368 1 0.816
ICKICK 0.734 0.252 -3 0.228
COTCOT 0.733 0.043 2 0.863
MOKMOK 0.732 0.326 1 0.777
SRPK3SRPK3 0.732 0.129 -3 0.137
PRP4PRP4 0.729 0.286 -3 0.165
PRKD1PRKD1 0.728 0.100 -3 0.261
NDR2NDR2 0.728 0.082 -3 0.297
CDKL1CDKL1 0.728 0.077 -3 0.188
PRKD2PRKD2 0.725 0.051 -3 0.211
PIM3PIM3 0.725 0.025 -3 0.245
MOSMOS 0.725 0.083 1 0.424
RSK2RSK2 0.722 0.003 -3 0.194
GRK1GRK1 0.722 0.112 -2 0.788
CDC7CDC7 0.721 -0.035 1 0.384
P90RSKP90RSK 0.717 -0.006 -3 0.187
ATRATR 0.717 -0.001 1 0.423
MAPKAPK2MAPKAPK2 0.716 0.002 -3 0.194
PRPKPRPK 0.715 -0.036 -1 0.825
NEK6NEK6 0.715 0.055 -2 0.844
AURCAURC 0.715 0.050 -2 0.688
SKMLCKSKMLCK 0.714 0.050 -2 0.898
PIM1PIM1 0.714 -0.001 -3 0.181
RSK3RSK3 0.714 -0.027 -3 0.175
PKN3PKN3 0.714 -0.022 -3 0.207
BUB1BUB1 0.713 0.289 -5 0.676
ERK7ERK7 0.713 0.200 2 0.610
MPSK1MPSK1 0.713 0.235 1 0.404
MAPKAPK3MAPKAPK3 0.713 -0.012 -3 0.198
NDR1NDR1 0.712 -0.016 -3 0.233
CHAK2CHAK2 0.712 0.024 -1 0.796
IKKBIKKB 0.712 -0.070 -2 0.743
RSK4RSK4 0.712 0.012 -3 0.221
GSK3AGSK3A 0.711 0.192 4 0.516
NUAK2NUAK2 0.710 -0.015 -3 0.206
PKCAPKCA 0.710 0.062 2 0.792
PKN2PKN2 0.710 -0.047 -3 0.180
GRK7GRK7 0.710 0.067 1 0.372
PKCDPKCD 0.710 0.022 2 0.823
PKCBPKCB 0.709 0.022 2 0.805
MLK3MLK3 0.709 0.055 2 0.803
TBK1TBK1 0.709 -0.073 1 0.307
MLK2MLK2 0.708 0.062 2 0.841
WNK1WNK1 0.708 -0.042 -2 0.914
PKACBPKACB 0.708 0.019 -2 0.703
MST4MST4 0.708 -0.039 2 0.881
IKKAIKKA 0.708 0.033 -2 0.731
LATS1LATS1 0.708 0.136 -3 0.334
IKKEIKKE 0.708 -0.070 1 0.306
CAMK1BCAMK1B 0.707 -0.066 -3 0.185
PDHK4PDHK4 0.707 -0.137 1 0.421
PKACGPKACG 0.707 -0.012 -2 0.769
MNK2MNK2 0.706 0.040 -2 0.813
AKT2AKT2 0.706 -0.009 -3 0.129
GCN2GCN2 0.706 -0.139 2 0.786
LATS2LATS2 0.706 -0.001 -5 0.587
CK1ECK1E 0.706 -0.041 -3 0.112
GRK5GRK5 0.705 -0.087 -3 0.212
NIKNIK 0.705 -0.043 -3 0.204
MLK1MLK1 0.705 -0.069 2 0.849
BMPR2BMPR2 0.705 -0.113 -2 0.868
PRKXPRKX 0.705 0.010 -3 0.179
CAMLCKCAMLCK 0.705 -0.004 -2 0.866
DSTYKDSTYK 0.704 -0.144 2 0.878
ULK2ULK2 0.704 -0.143 2 0.785
PKCGPKCG 0.704 0.007 2 0.801
P70S6KBP70S6KB 0.704 -0.043 -3 0.167
PRKD3PRKD3 0.703 -0.027 -3 0.150
NEK7NEK7 0.703 -0.079 -3 0.245
MNK1MNK1 0.703 0.030 -2 0.816
RAF1RAF1 0.703 -0.164 1 0.363
PKG2PKG2 0.702 0.026 -2 0.707
PDHK1PDHK1 0.702 -0.130 1 0.398
DAPK2DAPK2 0.702 -0.028 -3 0.210
CK1DCK1D 0.702 -0.024 -3 0.095
TGFBR2TGFBR2 0.701 -0.048 -2 0.775
SGK3SGK3 0.701 -0.012 -3 0.181
CAMK2DCAMK2D 0.701 -0.052 -3 0.211
PHKG1PHKG1 0.700 -0.028 -3 0.203
PKCZPKCZ 0.700 0.003 2 0.823
AMPKA2AMPKA2 0.699 -0.036 -3 0.215
CAMK2ACAMK2A 0.699 0.001 2 0.713
AMPKA1AMPKA1 0.699 -0.054 -3 0.224
IRE1IRE1 0.699 -0.049 1 0.359
CAMK2GCAMK2G 0.698 -0.101 2 0.732
NEK9NEK9 0.698 -0.085 2 0.858
PAK6PAK6 0.698 -0.003 -2 0.731
RIPK3RIPK3 0.698 -0.117 3 0.631
BMPR1BBMPR1B 0.698 -0.018 1 0.348
PAK1PAK1 0.698 -0.027 -2 0.814
SMG1SMG1 0.697 -0.025 1 0.401
MARK4MARK4 0.696 -0.052 4 0.735
CK1A2CK1A2 0.696 -0.046 -3 0.086
MSK2MSK2 0.696 -0.055 -3 0.170
ULK1ULK1 0.696 -0.147 -3 0.189
TSSK1TSSK1 0.696 -0.007 -3 0.252
MASTLMASTL 0.696 -0.099 -2 0.817
VRK2VRK2 0.695 0.138 1 0.465
BCKDKBCKDK 0.695 -0.111 -1 0.743
PIM2PIM2 0.695 -0.023 -3 0.152
PAK3PAK3 0.695 -0.045 -2 0.808
DLKDLK 0.694 -0.086 1 0.368
PKCHPKCH 0.694 -0.037 2 0.782
MSK1MSK1 0.694 -0.035 -3 0.165
HUNKHUNK 0.694 -0.120 2 0.808
DNAPKDNAPK 0.693 -0.012 1 0.383
CK1G1CK1G1 0.693 -0.072 -3 0.091
TSSK2TSSK2 0.693 -0.028 -5 0.704
NEK2NEK2 0.692 -0.048 2 0.846
AKT1AKT1 0.692 -0.019 -3 0.150
YSK4YSK4 0.691 -0.064 1 0.325
AKT3AKT3 0.691 -0.009 -3 0.128
MST3MST3 0.690 0.008 2 0.888
IRE2IRE2 0.690 -0.046 2 0.782
NIM1NIM1 0.690 -0.084 3 0.679
MELKMELK 0.690 -0.080 -3 0.188
GRK6GRK6 0.690 -0.136 1 0.363
PKACAPKACA 0.690 -0.011 -2 0.657
GSK3BGSK3B 0.690 0.070 4 0.510
AURBAURB 0.689 -0.011 -2 0.681
MLK4MLK4 0.689 -0.052 2 0.763
PKRPKR 0.689 -0.053 1 0.386
DCAMKL1DCAMKL1 0.689 -0.040 -3 0.190
CAMK2BCAMK2B 0.689 -0.043 2 0.683
TTBK2TTBK2 0.689 -0.144 2 0.724
QSKQSK 0.689 -0.046 4 0.709
GRK4GRK4 0.688 -0.114 -2 0.813
SGK1SGK1 0.688 -0.010 -3 0.113
PASKPASK 0.688 0.050 -3 0.286
PINK1PINK1 0.688 0.031 1 0.542
CAMK4CAMK4 0.688 -0.115 -3 0.185
ANKRD3ANKRD3 0.688 -0.115 1 0.385
CHAK1CHAK1 0.688 -0.076 2 0.799
ALK4ALK4 0.688 -0.048 -2 0.825
TGFBR1TGFBR1 0.687 -0.030 -2 0.795
PKCEPKCE 0.687 -0.000 2 0.797
WNK3WNK3 0.687 -0.202 1 0.354
NUAK1NUAK1 0.687 -0.081 -3 0.178
SBKSBK 0.686 0.032 -3 0.090
RIPK1RIPK1 0.686 -0.171 1 0.357
ATMATM 0.685 -0.085 1 0.387
TLK2TLK2 0.685 -0.033 1 0.354
QIKQIK 0.684 -0.111 -3 0.199
PKCTPKCT 0.684 -0.039 2 0.786
SIKSIK 0.684 -0.085 -3 0.155
MYLK4MYLK4 0.684 -0.067 -2 0.801
TAO3TAO3 0.684 0.012 1 0.370
NEK5NEK5 0.684 0.011 1 0.361
CHK1CHK1 0.683 -0.025 -3 0.263
PAK2PAK2 0.683 -0.062 -2 0.795
DRAK1DRAK1 0.682 -0.091 1 0.323
ACVR2BACVR2B 0.681 -0.081 -2 0.777
MEK1MEK1 0.681 -0.145 2 0.817
LKB1LKB1 0.681 0.069 -3 0.228
ZAKZAK 0.680 -0.070 1 0.336
MAPKAPK5MAPKAPK5 0.680 -0.115 -3 0.126
BRSK1BRSK1 0.679 -0.090 -3 0.176
P70S6KP70S6K 0.679 -0.076 -3 0.127
PKCIPKCI 0.679 -0.041 2 0.802
AURAAURA 0.678 -0.029 -2 0.643
BRSK2BRSK2 0.678 -0.105 -3 0.182
ACVR2AACVR2A 0.678 -0.094 -2 0.762
CAMK1GCAMK1G 0.678 -0.100 -3 0.134
GRK2GRK2 0.678 -0.080 -2 0.709
MEKK1MEKK1 0.678 -0.075 1 0.359
PKN1PKN1 0.678 -0.058 -3 0.131
PLK4PLK4 0.677 -0.032 2 0.612
MEK5MEK5 0.677 -0.102 2 0.821
GCKGCK 0.677 0.028 1 0.355
IRAK4IRAK4 0.677 -0.068 1 0.344
MARK3MARK3 0.676 -0.060 4 0.652
FAM20CFAM20C 0.676 -0.051 2 0.508
ALK2ALK2 0.676 -0.068 -2 0.801
WNK4WNK4 0.676 -0.099 -2 0.909
MEKK2MEKK2 0.676 -0.090 2 0.818
PAK5PAK5 0.675 -0.038 -2 0.666
TNIKTNIK 0.675 0.036 3 0.807
CK1ACK1A 0.675 -0.042 -3 0.066
PERKPERK 0.675 -0.118 -2 0.819
PLK1PLK1 0.674 -0.151 -2 0.758
SSTKSSTK 0.674 -0.023 4 0.699
MAP3K15MAP3K15 0.674 0.043 1 0.342
DCAMKL2DCAMKL2 0.674 -0.076 -3 0.182
NEK11NEK11 0.674 -0.076 1 0.364
PAK4PAK4 0.674 -0.021 -2 0.668
ROCK2ROCK2 0.673 -0.004 -3 0.189
CHK2CHK2 0.673 -0.065 -3 0.095
KHS1KHS1 0.673 0.028 1 0.349
PHKG2PHKG2 0.672 -0.109 -3 0.149
PDK1PDK1 0.672 -0.037 1 0.385
CAMKK2CAMKK2 0.672 0.012 -2 0.755
HGKHGK 0.672 -0.007 3 0.803
HPK1HPK1 0.672 -0.027 1 0.354
BMPR1ABMPR1A 0.671 -0.071 1 0.330
CAMK1DCAMK1D 0.671 -0.077 -3 0.132
MEKK3MEKK3 0.671 -0.180 1 0.357
KHS2KHS2 0.670 0.022 1 0.360
HRIHRI 0.670 -0.154 -2 0.836
SMMLCKSMMLCK 0.670 -0.082 -3 0.170
MRCKBMRCKB 0.670 -0.040 -3 0.136
GAKGAK 0.669 -0.057 1 0.405
PBKPBK 0.669 -0.002 1 0.367
TAO2TAO2 0.669 -0.055 2 0.866
GRK3GRK3 0.669 -0.082 -2 0.667
MST2MST2 0.669 -0.042 1 0.349
EEF2KEEF2K 0.669 -0.032 3 0.750
LOKLOK 0.668 -0.021 -2 0.768
NEK1NEK1 0.668 0.009 1 0.337
DAPK3DAPK3 0.668 -0.053 -3 0.178
CAMKK1CAMKK1 0.668 -0.088 -2 0.750
MARK2MARK2 0.667 -0.093 4 0.616
LRRK2LRRK2 0.667 -0.004 2 0.850
SNRKSNRK 0.667 -0.175 2 0.658
MEKK6MEKK6 0.667 -0.062 1 0.358
NEK4NEK4 0.667 -0.064 1 0.337
HASPINHASPIN 0.667 0.024 -1 0.658
SLKSLK 0.666 -0.024 -2 0.710
CAMK1ACAMK1A 0.666 -0.059 -3 0.109
MINKMINK 0.666 -0.064 1 0.334
PLK3PLK3 0.665 -0.148 2 0.702
NEK8NEK8 0.665 -0.117 2 0.841
CRIKCRIK 0.665 -0.013 -3 0.183
BRAFBRAF 0.665 -0.153 -4 0.780
TLK1TLK1 0.664 -0.134 -2 0.813
MRCKAMRCKA 0.664 -0.053 -3 0.153
MARK1MARK1 0.664 -0.116 4 0.676
DAPK1DAPK1 0.664 -0.064 -3 0.161
CK2A2CK2A2 0.662 -0.064 1 0.299
VRK1VRK1 0.662 -0.036 2 0.851
TAK1TAK1 0.661 -0.105 1 0.348
DMPK1DMPK1 0.660 -0.023 -3 0.150
MST1MST1 0.659 -0.055 1 0.333
PDHK3_TYRPDHK3_TYR 0.659 0.311 4 0.848
YSK1YSK1 0.659 -0.055 2 0.849
TTBK1TTBK1 0.659 -0.158 2 0.634
OSR1OSR1 0.659 0.009 2 0.812
ROCK1ROCK1 0.656 -0.043 -3 0.141
CK2A1CK2A1 0.655 -0.064 1 0.285
AAK1AAK1 0.655 0.058 1 0.342
LIMK2_TYRLIMK2_TYR 0.655 0.193 -3 0.256
PKG1PKG1 0.653 -0.058 -2 0.621
BIKEBIKE 0.653 0.008 1 0.365
STK33STK33 0.653 -0.100 2 0.608
MYO3BMYO3B 0.652 -0.006 2 0.861
PDHK4_TYRPDHK4_TYR 0.650 0.184 2 0.823
PLK2PLK2 0.650 -0.100 -3 0.166
TESK1_TYRTESK1_TYR 0.650 0.149 3 0.813
MEK2MEK2 0.648 -0.149 2 0.799
PKMYT1_TYRPKMYT1_TYR 0.648 0.118 3 0.775
NEK3NEK3 0.647 -0.121 1 0.343
ASK1ASK1 0.646 -0.012 1 0.336
CK1G3CK1G3 0.646 -0.070 -3 0.050
IRAK1IRAK1 0.646 -0.251 -1 0.717
MAP2K4_TYRMAP2K4_TYR 0.645 0.035 -1 0.836
TAO1TAO1 0.644 -0.043 1 0.322
MYO3AMYO3A 0.644 -0.041 1 0.351
YANK3YANK3 0.641 -0.058 2 0.384
MAP2K6_TYRMAP2K6_TYR 0.641 -0.009 -1 0.840
TTKTTK 0.641 -0.072 -2 0.788
RIPK2RIPK2 0.640 -0.216 1 0.310
MAP2K7_TYRMAP2K7_TYR 0.640 -0.043 2 0.823
BMPR2_TYRBMPR2_TYR 0.640 -0.012 -1 0.835
PDHK1_TYRPDHK1_TYR 0.638 -0.028 -1 0.834
JAK2JAK2 0.636 0.041 1 0.380
LIMK1_TYRLIMK1_TYR 0.636 0.009 2 0.840
PINK1_TYRPINK1_TYR 0.635 -0.121 1 0.411
RETRET 0.634 -0.041 1 0.376
ABL2ABL2 0.634 0.024 -1 0.752
ALPHAK3ALPHAK3 0.633 -0.088 -1 0.727
TNNI3K_TYRTNNI3K_TYR 0.631 0.036 1 0.396
EPHB4EPHB4 0.631 -0.013 -1 0.770
JAK1JAK1 0.630 0.024 1 0.337
ABL1ABL1 0.630 0.005 -1 0.745
ROS1ROS1 0.630 -0.030 3 0.679
EPHA6EPHA6 0.630 -0.055 -1 0.801
CSF1RCSF1R 0.630 -0.013 3 0.707
TYK2TYK2 0.630 -0.081 1 0.364
MST1RMST1R 0.629 -0.041 3 0.736
TYRO3TYRO3 0.629 -0.037 3 0.720
TXKTXK 0.628 -0.020 1 0.347
TNK2TNK2 0.627 -0.003 3 0.658
TNK1TNK1 0.626 0.018 3 0.700
STLK3STLK3 0.626 -0.118 1 0.313
CK1G2CK1G2 0.625 -0.064 -3 0.070
FGRFGR 0.625 -0.087 1 0.360
NEK10_TYRNEK10_TYR 0.624 -0.057 1 0.314
LCKLCK 0.624 -0.037 -1 0.803
JAK3JAK3 0.622 -0.082 1 0.363
YES1YES1 0.622 -0.072 -1 0.803
ITKITK 0.622 -0.045 -1 0.768
HCKHCK 0.620 -0.075 -1 0.800
BLKBLK 0.620 -0.050 -1 0.795
DDR1DDR1 0.619 -0.125 4 0.739
KDRKDR 0.619 -0.055 3 0.651
WEE1_TYRWEE1_TYR 0.618 -0.054 -1 0.708
FERFER 0.618 -0.132 1 0.379
EPHA4EPHA4 0.618 -0.058 2 0.705
EPHB1EPHB1 0.617 -0.086 1 0.359
KITKIT 0.617 -0.083 3 0.709
FGFR2FGFR2 0.615 -0.080 3 0.700
METMET 0.615 -0.049 3 0.712
MERTKMERTK 0.615 -0.049 3 0.686
BMXBMX 0.615 -0.057 -1 0.692
EPHB3EPHB3 0.615 -0.079 -1 0.754
SRMSSRMS 0.614 -0.115 1 0.354
TEKTEK 0.614 -0.048 3 0.639
FYNFYN 0.613 -0.056 -1 0.789
DDR2DDR2 0.613 -0.006 3 0.630
AXLAXL 0.612 -0.077 3 0.686
EPHB2EPHB2 0.612 -0.091 -1 0.742
PDGFRBPDGFRB 0.612 -0.134 3 0.715
FGFR1FGFR1 0.611 -0.077 3 0.666
INSRRINSRR 0.610 -0.148 3 0.649
YANK2YANK2 0.610 -0.075 2 0.395
PDGFRAPDGFRA 0.608 -0.140 3 0.714
TECTEC 0.607 -0.109 -1 0.693
FLT3FLT3 0.607 -0.178 3 0.711
BTKBTK 0.607 -0.148 -1 0.739
EPHA7EPHA7 0.607 -0.074 2 0.715
FLT1FLT1 0.607 -0.121 -1 0.769
ALKALK 0.606 -0.101 3 0.624
FRKFRK 0.606 -0.094 -1 0.790
PTK6PTK6 0.606 -0.144 -1 0.697
FGFR3FGFR3 0.605 -0.091 3 0.665
EPHA1EPHA1 0.604 -0.094 3 0.684
LYNLYN 0.604 -0.085 3 0.620
SYKSYK 0.603 -0.053 -1 0.739
PTK2BPTK2B 0.602 -0.059 -1 0.722
LTKLTK 0.602 -0.123 3 0.643
EPHA3EPHA3 0.602 -0.096 2 0.681
MATKMATK 0.602 -0.086 -1 0.660
ERBB2ERBB2 0.600 -0.153 1 0.335
NTRK3NTRK3 0.600 -0.108 -1 0.713
SRCSRC 0.600 -0.103 -1 0.771
EGFREGFR 0.599 -0.093 1 0.290
ZAP70ZAP70 0.599 -0.019 -1 0.675
PTK2PTK2 0.598 -0.050 -1 0.764
NTRK1NTRK1 0.598 -0.180 -1 0.754
EPHA8EPHA8 0.597 -0.090 -1 0.744
INSRINSR 0.597 -0.145 3 0.631
NTRK2NTRK2 0.596 -0.187 3 0.663
FLT4FLT4 0.595 -0.168 3 0.639
EPHA5EPHA5 0.594 -0.108 2 0.680
MUSKMUSK 0.594 -0.098 1 0.278
CSKCSK 0.593 -0.122 2 0.720
FGFR4FGFR4 0.593 -0.101 -1 0.700
EPHA2EPHA2 0.589 -0.082 -1 0.715
ERBB4ERBB4 0.587 -0.085 1 0.304
IGF1RIGF1R 0.581 -0.135 3 0.575
FESFES 0.570 -0.137 -1 0.662