Motif 217 (n=97)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5PL33 | KRBA1 | S288 | ochoa | Protein KRBA1 | None |
| O15020 | SPTBN2 | S2171 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15169 | AXIN1 | S469 | psp | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
| O43149 | ZZEF1 | S1509 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O43683 | BUB1 | S649 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60244 | MED14 | S986 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60292 | SIPA1L3 | S1144 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O94875 | SORBS2 | S248 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94887 | FARP2 | S387 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95359 | TACC2 | S2248 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95398 | RAPGEF3 | S528 | ochoa | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}. |
| P10721 | KIT | S931 | ochoa | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:10397721, ECO:0000269|PubMed:12444928, ECO:0000269|PubMed:12511554, ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:17904548, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21640708, ECO:0000269|PubMed:7520444, ECO:0000269|PubMed:9528781}. |
| P11308 | ERG | S39 | psp | Transcriptional regulator ERG (Transforming protein ERG) | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| P15336 | ATF2 | S338 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P18583 | SON | S1759 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P21359 | NF1 | S2496 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P23511 | NFYA | S320 | psp | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1. {ECO:0000269|PubMed:12741956}. |
| P43243 | MATR3 | S157 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P46527 | CDKN1B | S178 | ochoa|psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
| P67809 | YBX1 | S136 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78413 | IRX4 | S258 | ochoa | Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) | Likely to be an important mediator of ventricular differentiation during cardiac development. |
| P78559 | MAP1A | S986 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01484 | ANK2 | S1810 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1905 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1917 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1940 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01484 | ANK2 | S1964 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q04721 | NOTCH2 | S2070 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q05469 | LIPE | S950 | ochoa|psp | Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:8812477). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). {ECO:0000250|UniProtKB:P15304, ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:15716583, ECO:0000269|PubMed:15955102, ECO:0000269|PubMed:19800417, ECO:0000269|PubMed:8812477}. |
| Q09666 | AHNAK | S2150 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q13077 | TRAF1 | S66 | ochoa | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
| Q13191 | CBLB | S656 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13542 | EIF4EBP2 | S25 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q13563 | PKD2 | S166 | ochoa | Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2) | Forms a nonselective cation channel (PubMed:11854751, PubMed:11991947, PubMed:15692563, PubMed:26269590, PubMed:27071085, PubMed:31441214, PubMed:39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed:31441214, PubMed:33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed:27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed:31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed:11854751, PubMed:11991947, PubMed:27214281, PubMed:29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity). {ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751, ECO:0000269|PubMed:11991947, ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:26269590, ECO:0000269|PubMed:27071085, ECO:0000269|PubMed:27214281, ECO:0000269|PubMed:29899465, ECO:0000269|PubMed:31441214, ECO:0000269|PubMed:33164752, ECO:0000269|PubMed:39009345}. |
| Q13796 | SHROOM2 | S1173 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14152 | EIF3A | S978 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| Q14157 | UBAP2L | S439 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14160 | SCRIB | S1437 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14511 | NEDD9 | Y168 | ochoa | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250|UniProtKB:A0A8I3PDQ1, ECO:0000250|UniProtKB:O35177, ECO:0000269|PubMed:17174122, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:9020138}. |
| Q15742 | NAB2 | S193 | ochoa | NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER) | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S556 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T1V6 | DDX59 | S64 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5T5P2 | KIAA1217 | S526 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VT97 | SYDE2 | S64 | ochoa | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q5VZK9 | CARMIL1 | S1094 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q6ICG6 | KIAA0930 | S279 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6IQ26 | DENND5A | S1068 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6Y7W6 | GIGYF2 | S236 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q702N8 | XIRP1 | S138 | ochoa | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250|UniProtKB:O70373, ECO:0000269|PubMed:15454575}. |
| Q7Z5L9 | IRF2BP2 | S71 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6L1 | TECPR1 | S412 | ochoa | Tectonin beta-propeller repeat-containing protein 1 | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
| Q86UE8 | TLK2 | S99 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86VQ6 | TXNRD3 | S32 | ochoa | Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene) (Thioredoxin reductase TR2) | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}. |
| Q8IWX8 | CHERP | S822 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IYB3 | SRRM1 | S597 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N183 | NDUFAF2 | S148 | ochoa | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein) | Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:19384974, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:38949024}. |
| Q8N2Y8 | RUSC2 | S1368 | ochoa | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) | Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}. |
| Q8N3D4 | EHBP1L1 | S462 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
| Q8NDV7 | TNRC6A | Y1574 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8TD08 | MAPK15 | S362 | psp | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q8WXH0 | SYNE2 | S6389 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92610 | ZNF592 | S441 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92734 | TFG | S183 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q96F46 | IL17RA | S792 | psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96S55 | WRNIP1 | S65 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99618 | CDCA3 | S165 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99959 | PKP2 | S131 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BRD0 | BUD13 | S139 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRD0 | BUD13 | S151 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRD0 | BUD13 | S163 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRR8 | GPATCH1 | S199 | ochoa | G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) | None |
| Q9BV36 | MLPH | S266 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BW71 | HIRIP3 | S492 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9C0C2 | TNKS1BP1 | S228 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H3P2 | NELFA | S233 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H4M7 | PLEKHA4 | S194 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H6Y5 | MAGIX | S272 | ochoa | PDZ domain-containing protein MAGIX | None |
| Q9HAF1 | MEAF6 | S122 | ochoa | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}. |
| Q9NS56 | TOPORS | S194 | ochoa | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NTJ3 | SMC4 | S22 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NWS9 | ZNF446 | S362 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
| Q9NX94 | WBP1L | S159 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NYZ3 | GTSE1 | S520 | ochoa | G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) | May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. |
| Q9P107 | GMIP | S919 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P1Y6 | PHRF1 | S925 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P1Z0 | ZBTB4 | S715 | ochoa | Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) | Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}. |
| Q9P2Y4 | ZNF219 | S684 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UGU0 | TCF20 | S640 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9ULI4 | KIF26A | S1231 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9UQ35 | SRRM2 | S311 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y4B5 | MTCL1 | S1536 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4L1 | HYOU1 | S964 | ochoa | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4) | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}. |
| Q9Y6R1 | SLC4A4 | S245 | ochoa | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) | Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Q6PKG0 | LARP1 | S830 | Sugiyama | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q92620 | DHX38 | S220 | Sugiyama | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) | Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}. |
| P13688 | CEACAM1 | S472 | PSP | Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) | [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}. |
| Q96HN2 | AHCYL2 | S107 | Sugiyama | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9669937 | Drug resistance of KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669921 | KIT mutants bind TKIs | 0.006685 | 2.175 |
| R-HSA-9669914 | Dasatinib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669936 | Sorafenib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669934 | Sunitinib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669917 | Imatinib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.006685 | 2.175 |
| R-HSA-9669929 | Regorafenib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669924 | Masitinib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-9669926 | Nilotinib-resistant KIT mutants | 0.006685 | 2.175 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.004695 | 2.328 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.000617 | 3.210 |
| R-HSA-72172 | mRNA Splicing | 0.000826 | 3.083 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.004156 | 2.381 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.001735 | 2.761 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.004776 | 2.321 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.002133 | 2.671 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.001059 | 2.975 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.006544 | 2.184 |
| R-HSA-425381 | Bicarbonate transporters | 0.004108 | 2.386 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.008966 | 2.047 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.010273 | 1.988 |
| R-HSA-9669935 | Signaling by juxtamembrane domain KIT mutants | 0.019921 | 1.701 |
| R-HSA-9680187 | Signaling by extracellular domain mutants of KIT | 0.019921 | 1.701 |
| R-HSA-9669933 | Signaling by kinase domain mutants of KIT | 0.019921 | 1.701 |
| R-HSA-5619054 | Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... | 0.019921 | 1.701 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.039449 | 1.404 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.052253 | 1.282 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.052253 | 1.282 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.058592 | 1.232 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.064888 | 1.188 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.071143 | 1.148 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.089659 | 1.047 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.089659 | 1.047 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.089659 | 1.047 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.089659 | 1.047 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.095750 | 1.019 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.095750 | 1.019 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.101800 | 0.992 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.101800 | 0.992 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.101800 | 0.992 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.101800 | 0.992 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.101800 | 0.992 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.101800 | 0.992 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.101800 | 0.992 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.021020 | 1.677 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.107810 | 0.967 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.113780 | 0.944 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.119711 | 0.922 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.119711 | 0.922 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.131454 | 0.881 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.148779 | 0.827 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.148779 | 0.827 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.154478 | 0.811 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.160139 | 0.796 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.165762 | 0.781 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.165762 | 0.781 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.171348 | 0.766 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.171348 | 0.766 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.176896 | 0.752 |
| R-HSA-72187 | mRNA 3'-end processing | 0.061898 | 1.208 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.198726 | 0.702 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.198726 | 0.702 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.204093 | 0.690 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.204093 | 0.690 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.103228 | 0.986 |
| R-HSA-4641257 | Degradation of AXIN | 0.255844 | 0.592 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.255844 | 0.592 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.131658 | 0.881 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.131658 | 0.881 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.270708 | 0.567 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.240679 | 0.619 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.160139 | 0.796 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.290071 | 0.537 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.154478 | 0.811 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.068621 | 1.164 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.068621 | 1.164 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.270708 | 0.567 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.198726 | 0.702 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.294832 | 0.530 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.171082 | 0.767 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.068621 | 1.164 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.265787 | 0.575 |
| R-HSA-167169 | HIV Transcription Elongation | 0.270708 | 0.567 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.045873 | 1.338 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.113780 | 0.944 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.131454 | 0.881 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.095750 | 1.019 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.193323 | 0.714 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.275598 | 0.560 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.096938 | 1.014 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.027278 | 1.564 |
| R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.064888 | 1.188 |
| R-HSA-4839744 | Signaling by APC mutants | 0.089659 | 1.047 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.095750 | 1.019 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.107810 | 0.967 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.125602 | 0.901 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.031348 | 1.504 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.171348 | 0.766 |
| R-HSA-9839394 | TGFBR3 expression | 0.187884 | 0.726 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.094867 | 1.023 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.161624 | 0.791 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.109645 | 0.960 |
| R-HSA-163560 | Triglyceride catabolism | 0.250822 | 0.601 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.294832 | 0.530 |
| R-HSA-69236 | G1 Phase | 0.294832 | 0.530 |
| R-HSA-6807070 | PTEN Regulation | 0.281335 | 0.551 |
| R-HSA-9620244 | Long-term potentiation | 0.187884 | 0.726 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.077356 | 1.112 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.204093 | 0.690 |
| R-HSA-68877 | Mitotic Prometaphase | 0.170864 | 0.767 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.044857 | 1.348 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.204093 | 0.690 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.214721 | 0.668 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.162074 | 0.790 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.122724 | 0.911 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.229354 | 0.639 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.107810 | 0.967 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.113949 | 0.943 |
| R-HSA-157118 | Signaling by NOTCH | 0.031248 | 1.505 |
| R-HSA-392517 | Rap1 signalling | 0.148779 | 0.827 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.230399 | 0.638 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.230399 | 0.638 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.299561 | 0.524 |
| R-HSA-3214847 | HATs acetylate histones | 0.168708 | 0.773 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.131454 | 0.881 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.017004 | 1.769 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.165762 | 0.781 |
| R-HSA-429947 | Deadenylation of mRNA | 0.182408 | 0.739 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.078795 | 1.104 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.101119 | 0.995 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.225735 | 0.646 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.099986 | 1.000 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.230399 | 0.638 |
| R-HSA-195721 | Signaling by WNT | 0.165921 | 0.780 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.143043 | 0.845 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.160139 | 0.796 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.198726 | 0.702 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.225208 | 0.647 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.195098 | 0.710 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.137268 | 0.862 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.117625 | 0.930 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.176896 | 0.752 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.020027 | 1.698 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.285279 | 0.545 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.192676 | 0.715 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.245768 | 0.609 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.275598 | 0.560 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.185800 | 0.731 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.204093 | 0.690 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.209425 | 0.679 |
| R-HSA-448424 | Interleukin-17 signaling | 0.096938 | 1.014 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.123282 | 0.909 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.171348 | 0.766 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.209425 | 0.679 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.230399 | 0.638 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.125602 | 0.901 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.072109 | 1.142 |
| R-HSA-8939211 | ESR-mediated signaling | 0.029946 | 1.524 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.228895 | 0.640 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.101800 | 0.992 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.160139 | 0.796 |
| R-HSA-8953854 | Metabolism of RNA | 0.216610 | 0.664 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.115779 | 0.936 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.077356 | 1.112 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.265787 | 0.575 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.221969 | 0.654 |
| R-HSA-74160 | Gene expression (Transcription) | 0.023091 | 1.637 |
| R-HSA-381042 | PERK regulates gene expression | 0.245768 | 0.609 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.151872 | 0.819 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.255844 | 0.592 |
| R-HSA-162582 | Signal Transduction | 0.223465 | 0.651 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.154481 | 0.811 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.273901 | 0.562 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.235556 | 0.628 |
| R-HSA-373760 | L1CAM interactions | 0.217057 | 0.663 |
| R-HSA-166520 | Signaling by NTRKs | 0.101344 | 0.994 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.163353 | 0.787 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.171348 | 0.766 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.071118 | 1.148 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.019524 | 1.709 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.101399 | 0.994 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.291238 | 0.536 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.248435 | 0.605 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.020763 | 1.683 |
| R-HSA-212436 | Generic Transcription Pathway | 0.033126 | 1.480 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.176896 | 0.752 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.109144 | 0.962 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.027005 | 1.569 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.037120 | 1.430 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.038331 | 1.416 |
| R-HSA-9607240 | FLT3 Signaling | 0.041695 | 1.380 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.014441 | 1.840 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.048104 | 1.318 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.280454 | 0.552 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.299561 | 0.524 |
| R-HSA-354192 | Integrin signaling | 0.230399 | 0.638 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.088109 | 1.055 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.234287 | 0.630 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.299561 | 0.524 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.225208 | 0.647 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.133915 | 0.873 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.147633 | 0.831 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.304259 | 0.517 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.304259 | 0.517 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.304259 | 0.517 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.304259 | 0.517 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.304259 | 0.517 |
| R-HSA-75153 | Apoptotic execution phase | 0.304259 | 0.517 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.315915 | 0.500 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.318165 | 0.497 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.318165 | 0.497 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.322739 | 0.491 |
| R-HSA-1989781 | PPARA activates gene expression | 0.323284 | 0.490 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.328187 | 0.484 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.331796 | 0.479 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.331796 | 0.479 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.331796 | 0.479 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.331796 | 0.479 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.335524 | 0.474 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.336279 | 0.473 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.336279 | 0.473 |
| R-HSA-1221632 | Meiotic synapsis | 0.336279 | 0.473 |
| R-HSA-1266738 | Developmental Biology | 0.339599 | 0.469 |
| R-HSA-72649 | Translation initiation complex formation | 0.340732 | 0.468 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.345156 | 0.462 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.345156 | 0.462 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.345270 | 0.462 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.349551 | 0.456 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.349551 | 0.456 |
| R-HSA-75893 | TNF signaling | 0.349551 | 0.456 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.349551 | 0.456 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.358252 | 0.446 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.358252 | 0.446 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.358585 | 0.445 |
| R-HSA-8979227 | Triglyceride metabolism | 0.362560 | 0.441 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.362560 | 0.441 |
| R-HSA-1640170 | Cell Cycle | 0.364132 | 0.439 |
| R-HSA-983189 | Kinesins | 0.366838 | 0.436 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.366838 | 0.436 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.366838 | 0.436 |
| R-HSA-450294 | MAP kinase activation | 0.371089 | 0.431 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.374220 | 0.427 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.375311 | 0.426 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.375311 | 0.426 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.375311 | 0.426 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.375311 | 0.426 |
| R-HSA-9707616 | Heme signaling | 0.375311 | 0.426 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.375311 | 0.426 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.379505 | 0.421 |
| R-HSA-6799198 | Complex I biogenesis | 0.379505 | 0.421 |
| R-HSA-373755 | Semaphorin interactions | 0.379505 | 0.421 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.379505 | 0.421 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.379505 | 0.421 |
| R-HSA-8848021 | Signaling by PTK6 | 0.379505 | 0.421 |
| R-HSA-2559583 | Cellular Senescence | 0.386135 | 0.413 |
| R-HSA-6798695 | Neutrophil degranulation | 0.399465 | 0.399 |
| R-HSA-167172 | Transcription of the HIV genome | 0.400060 | 0.398 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.400060 | 0.398 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.404931 | 0.393 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.408092 | 0.389 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.408092 | 0.389 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.412067 | 0.385 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.412067 | 0.385 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.412067 | 0.385 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.412067 | 0.385 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.412067 | 0.385 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.416017 | 0.381 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.416017 | 0.381 |
| R-HSA-4086398 | Ca2+ pathway | 0.419940 | 0.377 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.423837 | 0.373 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.423837 | 0.373 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.435373 | 0.361 |
| R-HSA-4086400 | PCP/CE pathway | 0.439167 | 0.357 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.442936 | 0.354 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.450399 | 0.346 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.454093 | 0.343 |
| R-HSA-109582 | Hemostasis | 0.455449 | 0.342 |
| R-HSA-1500620 | Meiosis | 0.465029 | 0.333 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.465029 | 0.333 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.465029 | 0.333 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.465029 | 0.333 |
| R-HSA-199991 | Membrane Trafficking | 0.467359 | 0.330 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.468626 | 0.329 |
| R-HSA-68882 | Mitotic Anaphase | 0.470897 | 0.327 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.473093 | 0.325 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.475748 | 0.323 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.483846 | 0.315 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.489709 | 0.310 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.496891 | 0.304 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.503301 | 0.298 |
| R-HSA-68886 | M Phase | 0.509254 | 0.293 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.509586 | 0.293 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.509963 | 0.292 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.513260 | 0.290 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.513260 | 0.290 |
| R-HSA-1296071 | Potassium Channels | 0.513260 | 0.290 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.516535 | 0.287 |
| R-HSA-422356 | Regulation of insulin secretion | 0.519789 | 0.284 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.519789 | 0.284 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.519789 | 0.284 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.519789 | 0.284 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.529420 | 0.276 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.532587 | 0.274 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.532587 | 0.274 |
| R-HSA-1483255 | PI Metabolism | 0.532587 | 0.274 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.538859 | 0.269 |
| R-HSA-4839726 | Chromatin organization | 0.540404 | 0.267 |
| R-HSA-9833110 | RSV-host interactions | 0.541964 | 0.266 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.545048 | 0.264 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.551154 | 0.259 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.551154 | 0.259 |
| R-HSA-211000 | Gene Silencing by RNA | 0.551154 | 0.259 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.554177 | 0.256 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.554177 | 0.256 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.554177 | 0.256 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.557179 | 0.254 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.560162 | 0.252 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.560162 | 0.252 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.568990 | 0.245 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.573375 | 0.242 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.577643 | 0.238 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.577643 | 0.238 |
| R-HSA-9675108 | Nervous system development | 0.578976 | 0.237 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.583315 | 0.234 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.583315 | 0.234 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.586123 | 0.232 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.586123 | 0.232 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.591683 | 0.228 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.591683 | 0.228 |
| R-HSA-68875 | Mitotic Prophase | 0.594435 | 0.226 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.599884 | 0.222 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.599884 | 0.222 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.602582 | 0.220 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.602582 | 0.220 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.603436 | 0.219 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.605261 | 0.218 |
| R-HSA-69206 | G1/S Transition | 0.610566 | 0.214 |
| R-HSA-69481 | G2/M Checkpoints | 0.615800 | 0.211 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.618770 | 0.208 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.623522 | 0.205 |
| R-HSA-1474165 | Reproduction | 0.626061 | 0.203 |
| R-HSA-9843745 | Adipogenesis | 0.628583 | 0.202 |
| R-HSA-5576891 | Cardiac conduction | 0.628583 | 0.202 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.631089 | 0.200 |
| R-HSA-9909396 | Circadian clock | 0.631089 | 0.200 |
| R-HSA-112316 | Neuronal System | 0.640464 | 0.194 |
| R-HSA-163685 | Integration of energy metabolism | 0.643368 | 0.192 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.645774 | 0.190 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.659881 | 0.181 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.667766 | 0.175 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.668974 | 0.175 |
| R-HSA-69242 | S Phase | 0.673430 | 0.172 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.673430 | 0.172 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.677827 | 0.169 |
| R-HSA-73887 | Death Receptor Signaling | 0.686444 | 0.163 |
| R-HSA-162587 | HIV Life Cycle | 0.692758 | 0.159 |
| R-HSA-9711097 | Cellular response to starvation | 0.694834 | 0.158 |
| R-HSA-877300 | Interferon gamma signaling | 0.696896 | 0.157 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.698945 | 0.156 |
| R-HSA-109581 | Apoptosis | 0.703001 | 0.153 |
| R-HSA-2262752 | Cellular responses to stress | 0.703710 | 0.153 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.711052 | 0.148 |
| R-HSA-5619102 | SLC transporter disorders | 0.712906 | 0.147 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.724360 | 0.140 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.726225 | 0.139 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.726225 | 0.139 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.726225 | 0.139 |
| R-HSA-1280218 | Adaptive Immune System | 0.727813 | 0.138 |
| R-HSA-611105 | Respiratory electron transport | 0.735362 | 0.133 |
| R-HSA-422475 | Axon guidance | 0.735657 | 0.133 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.744197 | 0.128 |
| R-HSA-3781865 | Diseases of glycosylation | 0.745929 | 0.127 |
| R-HSA-69275 | G2/M Transition | 0.749357 | 0.125 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.752740 | 0.123 |
| R-HSA-5617833 | Cilium Assembly | 0.756077 | 0.121 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.756975 | 0.121 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.757729 | 0.120 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.765823 | 0.116 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.772106 | 0.112 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.772106 | 0.112 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.773525 | 0.112 |
| R-HSA-428157 | Sphingolipid metabolism | 0.773650 | 0.111 |
| R-HSA-5357801 | Programmed Cell Death | 0.781218 | 0.107 |
| R-HSA-6805567 | Keratinization | 0.782701 | 0.106 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.791393 | 0.102 |
| R-HSA-397014 | Muscle contraction | 0.791393 | 0.102 |
| R-HSA-418990 | Adherens junctions interactions | 0.799740 | 0.097 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.802042 | 0.096 |
| R-HSA-8951664 | Neddylation | 0.803788 | 0.095 |
| R-HSA-162906 | HIV Infection | 0.811644 | 0.091 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.835646 | 0.078 |
| R-HSA-421270 | Cell-cell junction organization | 0.840070 | 0.076 |
| R-HSA-5688426 | Deubiquitination | 0.844375 | 0.073 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.845433 | 0.073 |
| R-HSA-168256 | Immune System | 0.860287 | 0.065 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.863309 | 0.064 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.865236 | 0.063 |
| R-HSA-446728 | Cell junction organization | 0.866994 | 0.062 |
| R-HSA-1483257 | Phospholipid metabolism | 0.881588 | 0.055 |
| R-HSA-1500931 | Cell-Cell communication | 0.897443 | 0.047 |
| R-HSA-9679506 | SARS-CoV Infections | 0.902039 | 0.045 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.902245 | 0.045 |
| R-HSA-8957322 | Metabolism of steroids | 0.902913 | 0.044 |
| R-HSA-1474244 | Extracellular matrix organization | 0.907462 | 0.042 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.913595 | 0.039 |
| R-HSA-449147 | Signaling by Interleukins | 0.933774 | 0.030 |
| R-HSA-913531 | Interferon Signaling | 0.935696 | 0.029 |
| R-HSA-5668914 | Diseases of metabolism | 0.952510 | 0.021 |
| R-HSA-72766 | Translation | 0.953161 | 0.021 |
| R-HSA-168249 | Innate Immune System | 0.953755 | 0.021 |
| R-HSA-9824446 | Viral Infection Pathways | 0.953918 | 0.020 |
| R-HSA-597592 | Post-translational protein modification | 0.974245 | 0.011 |
| R-HSA-556833 | Metabolism of lipids | 0.977870 | 0.010 |
| R-HSA-1643685 | Disease | 0.978265 | 0.010 |
| R-HSA-382551 | Transport of small molecules | 0.992080 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.997652 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.998156 | 0.001 |
| R-HSA-1430728 | Metabolism | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.822 | 0.450 | 1 | 0.787 |
HIPK2 |
0.821 | 0.586 | 1 | 0.894 |
CDK19 |
0.819 | 0.607 | 1 | 0.894 |
CDK8 |
0.817 | 0.606 | 1 | 0.895 |
CDK1 |
0.816 | 0.583 | 1 | 0.911 |
CDK18 |
0.816 | 0.607 | 1 | 0.894 |
KIS |
0.815 | 0.501 | 1 | 0.885 |
JNK2 |
0.813 | 0.629 | 1 | 0.893 |
P38G |
0.813 | 0.617 | 1 | 0.890 |
CDK3 |
0.813 | 0.527 | 1 | 0.901 |
DYRK2 |
0.812 | 0.566 | 1 | 0.886 |
HIPK4 |
0.812 | 0.473 | 1 | 0.785 |
CDK5 |
0.812 | 0.583 | 1 | 0.897 |
CDK7 |
0.810 | 0.583 | 1 | 0.905 |
JNK3 |
0.810 | 0.616 | 1 | 0.900 |
ERK1 |
0.808 | 0.608 | 1 | 0.872 |
CDK17 |
0.808 | 0.593 | 1 | 0.892 |
P38B |
0.806 | 0.618 | 1 | 0.878 |
P38D |
0.803 | 0.608 | 1 | 0.896 |
CDK13 |
0.803 | 0.549 | 1 | 0.898 |
DYRK4 |
0.802 | 0.545 | 1 | 0.910 |
SRPK1 |
0.802 | 0.300 | -3 | 0.707 |
CDK12 |
0.799 | 0.549 | 1 | 0.894 |
HIPK1 |
0.798 | 0.512 | 1 | 0.875 |
CDK16 |
0.798 | 0.564 | 1 | 0.893 |
MAK |
0.796 | 0.513 | -2 | 0.844 |
CLK2 |
0.796 | 0.330 | -3 | 0.689 |
P38A |
0.795 | 0.589 | 1 | 0.861 |
NLK |
0.793 | 0.489 | 1 | 0.796 |
SRPK2 |
0.792 | 0.244 | -3 | 0.631 |
COT |
0.792 | 0.072 | 2 | 0.798 |
JNK1 |
0.791 | 0.538 | 1 | 0.905 |
ICK |
0.790 | 0.380 | -3 | 0.777 |
DYRK1B |
0.789 | 0.502 | 1 | 0.895 |
DYRK1A |
0.789 | 0.464 | 1 | 0.862 |
CDK9 |
0.789 | 0.521 | 1 | 0.889 |
NDR2 |
0.789 | 0.138 | -3 | 0.791 |
ERK5 |
0.788 | 0.317 | 1 | 0.713 |
GRK1 |
0.788 | 0.166 | -2 | 0.760 |
CDC7 |
0.788 | 0.064 | 1 | 0.608 |
CDK10 |
0.787 | 0.511 | 1 | 0.892 |
MTOR |
0.787 | 0.195 | 1 | 0.610 |
CDK14 |
0.786 | 0.538 | 1 | 0.888 |
ERK2 |
0.786 | 0.544 | 1 | 0.868 |
PIM3 |
0.785 | 0.093 | -3 | 0.780 |
CDKL5 |
0.785 | 0.221 | -3 | 0.740 |
MOS |
0.784 | 0.141 | 1 | 0.641 |
CDKL1 |
0.781 | 0.177 | -3 | 0.745 |
HIPK3 |
0.781 | 0.469 | 1 | 0.830 |
SRPK3 |
0.781 | 0.208 | -3 | 0.676 |
CDK4 |
0.779 | 0.544 | 1 | 0.899 |
DYRK3 |
0.777 | 0.391 | 1 | 0.853 |
CDK6 |
0.777 | 0.519 | 1 | 0.879 |
PRPK |
0.775 | 0.004 | -1 | 0.815 |
CDK2 |
0.774 | 0.357 | 1 | 0.873 |
IKKA |
0.774 | 0.061 | -2 | 0.679 |
CLK4 |
0.773 | 0.244 | -3 | 0.693 |
MOK |
0.773 | 0.427 | 1 | 0.805 |
IKKB |
0.772 | -0.053 | -2 | 0.674 |
CLK1 |
0.772 | 0.261 | -3 | 0.671 |
ATR |
0.772 | 0.021 | 1 | 0.584 |
CHAK2 |
0.771 | 0.048 | -1 | 0.761 |
GRK7 |
0.770 | 0.099 | 1 | 0.530 |
NEK6 |
0.769 | 0.036 | -2 | 0.787 |
SKMLCK |
0.768 | 0.039 | -2 | 0.800 |
RSK2 |
0.768 | 0.046 | -3 | 0.717 |
TBK1 |
0.768 | -0.071 | 1 | 0.434 |
PIM1 |
0.767 | 0.064 | -3 | 0.724 |
PRP4 |
0.767 | 0.294 | -3 | 0.659 |
BMPR2 |
0.766 | -0.076 | -2 | 0.818 |
GCN2 |
0.765 | -0.096 | 2 | 0.742 |
BMPR1B |
0.765 | 0.030 | 1 | 0.553 |
PRKD1 |
0.765 | 0.061 | -3 | 0.765 |
GRK5 |
0.765 | -0.072 | -3 | 0.771 |
PDHK4 |
0.764 | -0.149 | 1 | 0.581 |
IKKE |
0.764 | -0.095 | 1 | 0.435 |
LATS2 |
0.764 | 0.029 | -5 | 0.655 |
NDR1 |
0.764 | -0.003 | -3 | 0.758 |
DSTYK |
0.763 | -0.119 | 2 | 0.813 |
TGFBR2 |
0.762 | -0.032 | -2 | 0.741 |
RAF1 |
0.762 | -0.149 | 1 | 0.525 |
CAMK2G |
0.762 | -0.082 | 2 | 0.766 |
P90RSK |
0.761 | 0.035 | -3 | 0.714 |
AURC |
0.761 | 0.049 | -2 | 0.571 |
ULK2 |
0.761 | -0.125 | 2 | 0.711 |
MLK3 |
0.759 | 0.032 | 2 | 0.662 |
MLK1 |
0.759 | -0.080 | 2 | 0.729 |
MPSK1 |
0.759 | 0.238 | 1 | 0.536 |
GSK3A |
0.759 | 0.170 | 4 | 0.469 |
CAMK1B |
0.759 | -0.063 | -3 | 0.771 |
RSK4 |
0.759 | 0.063 | -3 | 0.705 |
MLK2 |
0.758 | 0.038 | 2 | 0.751 |
PKCD |
0.758 | 0.012 | 2 | 0.706 |
PKN3 |
0.757 | -0.034 | -3 | 0.746 |
NEK7 |
0.757 | -0.123 | -3 | 0.755 |
MST4 |
0.757 | -0.026 | 2 | 0.774 |
LATS1 |
0.756 | 0.102 | -3 | 0.798 |
CAMLCK |
0.756 | -0.024 | -2 | 0.769 |
TGFBR1 |
0.756 | 0.017 | -2 | 0.747 |
MARK4 |
0.756 | -0.046 | 4 | 0.741 |
NUAK2 |
0.756 | -0.021 | -3 | 0.762 |
RSK3 |
0.756 | 0.009 | -3 | 0.704 |
DAPK2 |
0.756 | -0.024 | -3 | 0.777 |
PDHK1 |
0.756 | -0.163 | 1 | 0.549 |
WNK1 |
0.755 | -0.080 | -2 | 0.819 |
PRKD2 |
0.755 | 0.016 | -3 | 0.713 |
MAPKAPK2 |
0.755 | 0.014 | -3 | 0.677 |
PRKX |
0.754 | 0.060 | -3 | 0.638 |
NIK |
0.754 | -0.095 | -3 | 0.778 |
GRK4 |
0.754 | -0.103 | -2 | 0.792 |
PKACG |
0.753 | -0.018 | -2 | 0.645 |
GRK6 |
0.753 | -0.116 | 1 | 0.557 |
ALK4 |
0.753 | -0.020 | -2 | 0.773 |
PKACB |
0.752 | 0.036 | -2 | 0.577 |
PKCA |
0.752 | 0.030 | 2 | 0.645 |
CAMK2D |
0.752 | -0.041 | -3 | 0.749 |
MASTL |
0.752 | -0.115 | -2 | 0.759 |
ERK7 |
0.752 | 0.183 | 2 | 0.472 |
PAK1 |
0.751 | -0.013 | -2 | 0.721 |
PKCB |
0.751 | 0.002 | 2 | 0.651 |
P70S6KB |
0.751 | -0.017 | -3 | 0.715 |
RIPK3 |
0.750 | -0.146 | 3 | 0.612 |
CAMK2A |
0.750 | 0.011 | 2 | 0.761 |
IRE1 |
0.750 | -0.056 | 1 | 0.492 |
TLK2 |
0.750 | -0.008 | 1 | 0.515 |
HUNK |
0.750 | -0.148 | 2 | 0.741 |
PKCG |
0.749 | -0.011 | 2 | 0.655 |
CAMK2B |
0.749 | -0.020 | 2 | 0.743 |
ULK1 |
0.749 | -0.164 | -3 | 0.701 |
AMPKA1 |
0.749 | -0.056 | -3 | 0.770 |
MAPKAPK3 |
0.749 | -0.035 | -3 | 0.702 |
BCKDK |
0.748 | -0.143 | -1 | 0.699 |
CK1E |
0.748 | 0.021 | -3 | 0.531 |
VRK2 |
0.748 | 0.097 | 1 | 0.615 |
FAM20C |
0.748 | -0.036 | 2 | 0.545 |
MLK4 |
0.748 | -0.047 | 2 | 0.637 |
DLK |
0.748 | -0.158 | 1 | 0.534 |
ACVR2B |
0.748 | -0.041 | -2 | 0.748 |
PKN2 |
0.747 | -0.082 | -3 | 0.742 |
ATM |
0.747 | -0.068 | 1 | 0.534 |
DNAPK |
0.747 | -0.010 | 1 | 0.482 |
TTBK2 |
0.747 | -0.126 | 2 | 0.646 |
AMPKA2 |
0.747 | -0.025 | -3 | 0.744 |
NEK9 |
0.747 | -0.137 | 2 | 0.763 |
PKR |
0.746 | -0.015 | 1 | 0.543 |
MSK2 |
0.746 | -0.027 | -3 | 0.691 |
IRE2 |
0.745 | -0.059 | 2 | 0.666 |
PKCZ |
0.745 | -0.014 | 2 | 0.700 |
ACVR2A |
0.745 | -0.058 | -2 | 0.737 |
NIM1 |
0.744 | -0.098 | 3 | 0.628 |
BMPR1A |
0.744 | -0.016 | 1 | 0.539 |
AKT2 |
0.743 | 0.032 | -3 | 0.637 |
PAK3 |
0.743 | -0.062 | -2 | 0.703 |
WNK3 |
0.743 | -0.237 | 1 | 0.500 |
SMG1 |
0.743 | -0.059 | 1 | 0.547 |
QSK |
0.743 | -0.039 | 4 | 0.714 |
GRK2 |
0.742 | -0.057 | -2 | 0.682 |
ALK2 |
0.742 | -0.052 | -2 | 0.749 |
CHAK1 |
0.742 | -0.088 | 2 | 0.729 |
MNK1 |
0.742 | -0.002 | -2 | 0.709 |
PIM2 |
0.742 | 0.029 | -3 | 0.680 |
MSK1 |
0.742 | -0.010 | -3 | 0.687 |
MNK2 |
0.742 | -0.022 | -2 | 0.700 |
AURB |
0.740 | -0.017 | -2 | 0.567 |
TSSK1 |
0.740 | -0.060 | -3 | 0.793 |
PKG2 |
0.740 | -0.005 | -2 | 0.577 |
PASK |
0.740 | 0.040 | -3 | 0.808 |
CK2A2 |
0.740 | 0.011 | 1 | 0.569 |
AURA |
0.740 | -0.017 | -2 | 0.551 |
SGK3 |
0.739 | 0.001 | -3 | 0.695 |
MEK1 |
0.739 | -0.150 | 2 | 0.767 |
BRSK1 |
0.739 | -0.057 | -3 | 0.710 |
PINK1 |
0.739 | 0.030 | 1 | 0.679 |
YSK4 |
0.739 | -0.128 | 1 | 0.468 |
CK1G1 |
0.738 | -0.018 | -3 | 0.514 |
RIPK1 |
0.738 | -0.217 | 1 | 0.491 |
CK1D |
0.738 | 0.015 | -3 | 0.483 |
PKCH |
0.738 | -0.055 | 2 | 0.635 |
TAO3 |
0.737 | 0.017 | 1 | 0.514 |
PLK1 |
0.737 | -0.148 | -2 | 0.730 |
ANKRD3 |
0.737 | -0.230 | 1 | 0.536 |
GSK3B |
0.737 | 0.038 | 4 | 0.459 |
SIK |
0.737 | -0.059 | -3 | 0.680 |
PAK6 |
0.736 | -0.014 | -2 | 0.610 |
TSSK2 |
0.736 | -0.128 | -5 | 0.641 |
PHKG1 |
0.736 | -0.074 | -3 | 0.738 |
PAK2 |
0.735 | -0.081 | -2 | 0.699 |
MARK3 |
0.735 | -0.062 | 4 | 0.667 |
PERK |
0.734 | -0.073 | -2 | 0.777 |
DRAK1 |
0.734 | -0.117 | 1 | 0.500 |
NUAK1 |
0.734 | -0.075 | -3 | 0.706 |
GRK3 |
0.733 | -0.048 | -2 | 0.648 |
PRKD3 |
0.733 | -0.050 | -3 | 0.679 |
BRSK2 |
0.732 | -0.086 | -3 | 0.717 |
DCAMKL1 |
0.732 | -0.029 | -3 | 0.710 |
MST3 |
0.732 | -0.037 | 2 | 0.763 |
NEK2 |
0.732 | -0.144 | 2 | 0.738 |
PLK4 |
0.731 | -0.103 | 2 | 0.554 |
MEKK2 |
0.731 | -0.093 | 2 | 0.732 |
QIK |
0.731 | -0.152 | -3 | 0.740 |
PLK3 |
0.731 | -0.134 | 2 | 0.713 |
MELK |
0.731 | -0.104 | -3 | 0.716 |
CK2A1 |
0.730 | -0.004 | 1 | 0.556 |
MEKK1 |
0.730 | -0.114 | 1 | 0.504 |
MARK2 |
0.729 | -0.088 | 4 | 0.626 |
MEK5 |
0.729 | -0.168 | 2 | 0.750 |
PKACA |
0.729 | -0.002 | -2 | 0.527 |
BRAF |
0.728 | -0.132 | -4 | 0.778 |
ZAK |
0.728 | -0.138 | 1 | 0.475 |
NEK5 |
0.728 | -0.106 | 1 | 0.501 |
MYLK4 |
0.728 | -0.083 | -2 | 0.681 |
CK1A2 |
0.728 | -0.022 | -3 | 0.485 |
AKT1 |
0.728 | 0.004 | -3 | 0.649 |
LKB1 |
0.727 | 0.012 | -3 | 0.725 |
CAMK4 |
0.727 | -0.179 | -3 | 0.724 |
PKCT |
0.726 | -0.056 | 2 | 0.644 |
MEKK3 |
0.726 | -0.188 | 1 | 0.500 |
GAK |
0.726 | -0.019 | 1 | 0.568 |
WNK4 |
0.726 | -0.132 | -2 | 0.817 |
CHK1 |
0.725 | -0.083 | -3 | 0.743 |
IRAK4 |
0.724 | -0.125 | 1 | 0.467 |
GCK |
0.723 | -0.030 | 1 | 0.505 |
PKCE |
0.723 | -0.012 | 2 | 0.641 |
HRI |
0.723 | -0.185 | -2 | 0.785 |
PDHK3_TYR |
0.722 | 0.300 | 4 | 0.844 |
PDK1 |
0.722 | -0.047 | 1 | 0.506 |
SGK1 |
0.722 | 0.037 | -3 | 0.572 |
TLK1 |
0.722 | -0.165 | -2 | 0.779 |
DAPK3 |
0.721 | -0.035 | -3 | 0.723 |
MAP3K15 |
0.721 | -0.020 | 1 | 0.465 |
TNIK |
0.721 | -0.009 | 3 | 0.708 |
EEF2K |
0.720 | -0.047 | 3 | 0.696 |
SNRK |
0.720 | -0.205 | 2 | 0.611 |
MARK1 |
0.720 | -0.131 | 4 | 0.684 |
MAPKAPK5 |
0.720 | -0.130 | -3 | 0.634 |
TAO2 |
0.720 | -0.083 | 2 | 0.769 |
PAK4 |
0.718 | -0.037 | -2 | 0.575 |
AKT3 |
0.718 | 0.015 | -3 | 0.593 |
PAK5 |
0.718 | -0.050 | -2 | 0.564 |
VRK1 |
0.718 | -0.018 | 2 | 0.758 |
SMMLCK |
0.718 | -0.095 | -3 | 0.732 |
NEK11 |
0.717 | -0.167 | 1 | 0.500 |
P70S6K |
0.717 | -0.050 | -3 | 0.635 |
HGK |
0.717 | -0.054 | 3 | 0.712 |
CAMKK1 |
0.717 | -0.167 | -2 | 0.653 |
NEK8 |
0.717 | -0.177 | 2 | 0.740 |
KHS1 |
0.717 | -0.003 | 1 | 0.475 |
PKCI |
0.716 | -0.072 | 2 | 0.656 |
ROCK2 |
0.716 | 0.023 | -3 | 0.710 |
CAMKK2 |
0.715 | -0.120 | -2 | 0.660 |
MEKK6 |
0.715 | -0.085 | 1 | 0.487 |
PBK |
0.715 | 0.008 | 1 | 0.505 |
CAMK1G |
0.715 | -0.114 | -3 | 0.677 |
TTBK1 |
0.715 | -0.171 | 2 | 0.570 |
KHS2 |
0.714 | -0.005 | 1 | 0.495 |
LRRK2 |
0.714 | -0.067 | 2 | 0.770 |
MINK |
0.714 | -0.092 | 1 | 0.468 |
DAPK1 |
0.714 | -0.048 | -3 | 0.711 |
SSTK |
0.714 | -0.112 | 4 | 0.688 |
DCAMKL2 |
0.714 | -0.103 | -3 | 0.720 |
BUB1 |
0.713 | 0.039 | -5 | 0.587 |
PLK2 |
0.713 | -0.065 | -3 | 0.692 |
HASPIN |
0.713 | 0.019 | -1 | 0.646 |
HPK1 |
0.712 | -0.085 | 1 | 0.491 |
MST2 |
0.712 | -0.132 | 1 | 0.500 |
PDHK4_TYR |
0.712 | 0.110 | 2 | 0.824 |
MRCKB |
0.711 | -0.011 | -3 | 0.661 |
SBK |
0.711 | 0.060 | -3 | 0.532 |
CK1A |
0.711 | -0.005 | -3 | 0.406 |
TAK1 |
0.710 | -0.142 | 1 | 0.505 |
PHKG2 |
0.710 | -0.125 | -3 | 0.695 |
NEK4 |
0.709 | -0.180 | 1 | 0.463 |
PKMYT1_TYR |
0.708 | 0.115 | 3 | 0.696 |
MAP2K4_TYR |
0.708 | 0.055 | -1 | 0.812 |
TESK1_TYR |
0.707 | 0.051 | 3 | 0.709 |
SLK |
0.707 | -0.089 | -2 | 0.649 |
MAP2K6_TYR |
0.707 | 0.030 | -1 | 0.804 |
MRCKA |
0.707 | -0.029 | -3 | 0.670 |
LOK |
0.707 | -0.094 | -2 | 0.679 |
LIMK2_TYR |
0.707 | 0.144 | -3 | 0.792 |
CAMK1D |
0.707 | -0.075 | -3 | 0.622 |
PDHK1_TYR |
0.706 | 0.016 | -1 | 0.808 |
OSR1 |
0.706 | -0.032 | 2 | 0.722 |
NEK1 |
0.705 | -0.138 | 1 | 0.466 |
DMPK1 |
0.705 | 0.010 | -3 | 0.685 |
STK33 |
0.704 | -0.147 | 2 | 0.560 |
PKN1 |
0.704 | -0.070 | -3 | 0.645 |
YSK1 |
0.702 | -0.095 | 2 | 0.733 |
MEK2 |
0.701 | -0.188 | 2 | 0.737 |
MST1 |
0.701 | -0.172 | 1 | 0.478 |
MAP2K7_TYR |
0.701 | -0.093 | 2 | 0.797 |
IRAK1 |
0.701 | -0.299 | -1 | 0.711 |
TXK |
0.700 | 0.029 | 1 | 0.566 |
TTK |
0.698 | -0.092 | -2 | 0.768 |
BMPR2_TYR |
0.698 | -0.049 | -1 | 0.761 |
YANK3 |
0.698 | -0.057 | 2 | 0.374 |
CHK2 |
0.697 | -0.061 | -3 | 0.576 |
ASK1 |
0.697 | -0.073 | 1 | 0.462 |
PINK1_TYR |
0.697 | -0.147 | 1 | 0.571 |
CRIK |
0.697 | 0.002 | -3 | 0.665 |
ROCK1 |
0.696 | -0.028 | -3 | 0.666 |
BIKE |
0.695 | -0.026 | 1 | 0.490 |
MYO3B |
0.695 | -0.057 | 2 | 0.750 |
YES1 |
0.695 | -0.039 | -1 | 0.816 |
LIMK1_TYR |
0.694 | -0.029 | 2 | 0.782 |
PKG1 |
0.693 | -0.061 | -2 | 0.500 |
ABL2 |
0.693 | -0.013 | -1 | 0.751 |
RET |
0.693 | -0.098 | 1 | 0.506 |
LCK |
0.692 | -0.012 | -1 | 0.772 |
FGR |
0.692 | -0.054 | 1 | 0.528 |
CSF1R |
0.692 | -0.051 | 3 | 0.638 |
ROS1 |
0.692 | -0.058 | 3 | 0.642 |
BLK |
0.691 | -0.012 | -1 | 0.769 |
ALPHAK3 |
0.691 | -0.104 | -1 | 0.701 |
EPHB4 |
0.690 | -0.085 | -1 | 0.733 |
MYO3A |
0.690 | -0.095 | 1 | 0.486 |
CAMK1A |
0.689 | -0.082 | -3 | 0.598 |
TYK2 |
0.689 | -0.134 | 1 | 0.491 |
TYRO3 |
0.689 | -0.118 | 3 | 0.653 |
JAK2 |
0.688 | -0.090 | 1 | 0.497 |
MST1R |
0.688 | -0.114 | 3 | 0.656 |
AAK1 |
0.688 | 0.026 | 1 | 0.432 |
ABL1 |
0.688 | -0.031 | -1 | 0.754 |
TAO1 |
0.688 | -0.096 | 1 | 0.436 |
RIPK2 |
0.688 | -0.293 | 1 | 0.435 |
NEK3 |
0.688 | -0.159 | 1 | 0.447 |
ITK |
0.687 | -0.068 | -1 | 0.746 |
EPHA6 |
0.687 | -0.108 | -1 | 0.737 |
TNK2 |
0.686 | -0.067 | 3 | 0.583 |
FER |
0.686 | -0.134 | 1 | 0.567 |
SRMS |
0.686 | -0.095 | 1 | 0.545 |
HCK |
0.686 | -0.085 | -1 | 0.770 |
FYN |
0.685 | -0.023 | -1 | 0.752 |
JAK1 |
0.684 | -0.024 | 1 | 0.444 |
JAK3 |
0.682 | -0.134 | 1 | 0.497 |
BMX |
0.682 | -0.064 | -1 | 0.659 |
KIT |
0.682 | -0.115 | 3 | 0.630 |
TNNI3K_TYR |
0.682 | -0.007 | 1 | 0.518 |
NEK10_TYR |
0.681 | -0.074 | 1 | 0.416 |
INSRR |
0.681 | -0.148 | 3 | 0.607 |
DDR1 |
0.680 | -0.178 | 4 | 0.746 |
TNK1 |
0.680 | -0.048 | 3 | 0.646 |
FGFR2 |
0.680 | -0.113 | 3 | 0.624 |
MET |
0.679 | -0.099 | 3 | 0.612 |
KDR |
0.678 | -0.119 | 3 | 0.599 |
EPHA4 |
0.678 | -0.107 | 2 | 0.717 |
FLT3 |
0.677 | -0.155 | 3 | 0.648 |
CK1G3 |
0.677 | -0.054 | -3 | 0.367 |
MERTK |
0.677 | -0.119 | 3 | 0.610 |
WEE1_TYR |
0.677 | -0.076 | -1 | 0.704 |
EPHB1 |
0.677 | -0.158 | 1 | 0.533 |
TEC |
0.677 | -0.118 | -1 | 0.696 |
FGFR1 |
0.676 | -0.112 | 3 | 0.610 |
TEK |
0.675 | -0.112 | 3 | 0.586 |
EPHB2 |
0.675 | -0.144 | -1 | 0.714 |
EPHB3 |
0.674 | -0.150 | -1 | 0.718 |
PDGFRB |
0.674 | -0.199 | 3 | 0.647 |
PTK6 |
0.674 | -0.133 | -1 | 0.721 |
LYN |
0.674 | -0.101 | 3 | 0.588 |
STLK3 |
0.674 | -0.193 | 1 | 0.449 |
SRC |
0.673 | -0.077 | -1 | 0.767 |
BTK |
0.673 | -0.172 | -1 | 0.727 |
AXL |
0.672 | -0.165 | 3 | 0.610 |
FRK |
0.671 | -0.115 | -1 | 0.768 |
MATK |
0.670 | -0.093 | -1 | 0.686 |
FGFR3 |
0.670 | -0.131 | 3 | 0.599 |
ALK |
0.670 | -0.156 | 3 | 0.579 |
ERBB2 |
0.668 | -0.170 | 1 | 0.486 |
DDR2 |
0.668 | -0.063 | 3 | 0.573 |
FLT1 |
0.668 | -0.164 | -1 | 0.719 |
LTK |
0.668 | -0.164 | 3 | 0.595 |
PTK2B |
0.667 | -0.101 | -1 | 0.746 |
PDGFRA |
0.667 | -0.208 | 3 | 0.648 |
EPHA7 |
0.667 | -0.139 | 2 | 0.706 |
CSK |
0.666 | -0.105 | 2 | 0.720 |
INSR |
0.665 | -0.157 | 3 | 0.599 |
YANK2 |
0.665 | -0.081 | 2 | 0.386 |
EGFR |
0.664 | -0.092 | 1 | 0.425 |
NTRK3 |
0.664 | -0.140 | -1 | 0.695 |
NTRK1 |
0.664 | -0.212 | -1 | 0.733 |
EPHA1 |
0.662 | -0.179 | 3 | 0.599 |
SYK |
0.662 | -0.065 | -1 | 0.649 |
EPHA8 |
0.662 | -0.127 | -1 | 0.694 |
FGFR4 |
0.662 | -0.106 | -1 | 0.701 |
EPHA3 |
0.661 | -0.187 | 2 | 0.689 |
FLT4 |
0.661 | -0.200 | 3 | 0.610 |
CK1G2 |
0.660 | -0.059 | -3 | 0.443 |
NTRK2 |
0.659 | -0.237 | 3 | 0.601 |
EPHA5 |
0.659 | -0.163 | 2 | 0.694 |
PTK2 |
0.657 | -0.086 | -1 | 0.635 |
ERBB4 |
0.656 | -0.095 | 1 | 0.465 |
ZAP70 |
0.651 | -0.047 | -1 | 0.581 |
IGF1R |
0.649 | -0.167 | 3 | 0.541 |
MUSK |
0.647 | -0.150 | 1 | 0.410 |
EPHA2 |
0.647 | -0.158 | -1 | 0.641 |
FES |
0.640 | -0.156 | -1 | 0.655 |