Motif 215 (n=53)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O14497 | ARID1A | S1184 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O75152 | ZC3H11A | S116 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75376 | NCOR1 | S1383 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O95999 | BCL10 | S171 | psp | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| P14317 | HCLS1 | S320 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P27708 | CAD | S1828 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P52179 | MYOM1 | S1615 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54727 | RAD23B | S168 | ochoa | UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. |
| P78347 | GTF2I | S699 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| Q07157 | TJP1 | S1111 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q14161 | GIT2 | S634 | ochoa | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. {ECO:0000269|PubMed:10896954}. |
| Q14194 | CRMP1 | S542 | ochoa | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q14573 | ITPR3 | S946 | ochoa | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269|PubMed:30013099, ECO:0000269|PubMed:32949214, ECO:0000269|PubMed:35301323, ECO:0000269|PubMed:37898605, ECO:0000269|PubMed:8081734, ECO:0000269|PubMed:8288584}. |
| Q14676 | MDC1 | S1132 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1173 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1214 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1337 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1419 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1460 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1501 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1583 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S1624 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1705 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14766 | LTBP1 | S494 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q16555 | DPYSL2 | S542 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q5SW79 | CEP170 | S1384 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T1V6 | DDX59 | S37 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5UIP0 | RIF1 | S1403 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VTT5 | MYOM3 | S643 | ochoa | Myomesin-3 (Myomesin family member 3) | May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. {ECO:0000250}. |
| Q6GYQ0 | RALGAPA1 | S721 | ochoa | Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) | Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}. |
| Q6P5Z2 | PKN3 | S524 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q6UVJ0 | SASS6 | S507 | ochoa | Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) | Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). {ECO:0000250|UniProtKB:Q7ZVT3, ECO:0000250|UniProtKB:Q80UK7, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:22020124}. |
| Q76L83 | ASXL2 | S634 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7Z5J4 | RAI1 | S1394 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6E9 | RBBP6 | S815 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q8NI35 | PATJ | S645 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TF76 | HASPIN | S288 | ochoa|psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WUA4 | GTF3C2 | S773 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WWI1 | LMO7 | S1400 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WWN8 | ARAP3 | S1444 | ochoa | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
| Q8WXI9 | GATAD2B | S208 | ochoa | Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269|PubMed:11756549, ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:23644463, ECO:0000269|PubMed:28977666}. |
| Q92545 | TMEM131 | S1513 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92576 | PHF3 | S682 | ochoa | PHD finger protein 3 | None |
| Q96L14 | CEP170P1 | S93 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
| Q99706 | KIR2DL4 | S81 | ochoa | Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}. |
| Q9BTC0 | DIDO1 | S1541 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9C0D5 | TANC1 | S37 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9HC77 | CPAP | S892 | ochoa | Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) | Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}. |
| Q9NQS7 | INCENP | S510 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9P242 | NYAP2 | S206 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| P26641 | EEF1G | S25 | Sugiyama | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | Probably plays a role in anchoring the complex to other cellular components. |
| P17096 | HMGA1 | S64 | SIGNOR | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Q9NY33 | DPP3 | S225 | Sugiyama | Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:1515063, PubMed:3233187). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:11209758, PubMed:3233187, PubMed:9425109). {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.000168 | 3.775 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.000298 | 3.526 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.001477 | 2.831 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.002475 | 2.606 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.024540 | 1.610 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 0.027566 | 1.560 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.074745 | 1.126 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.080482 | 1.094 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.019101 | 1.719 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.116934 | 0.932 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.127862 | 0.893 |
| R-HSA-72187 | mRNA 3'-end processing | 0.170265 | 0.769 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.198238 | 0.703 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.198238 | 0.703 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.205705 | 0.687 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.039577 | 1.403 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.083338 | 1.079 |
| R-HSA-191650 | Regulation of gap junction activity | 0.018461 | 1.734 |
| R-HSA-162592 | Integration of provirus | 0.045528 | 1.342 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.009127 | 2.040 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.105871 | 0.975 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.054387 | 1.265 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.057322 | 1.242 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.016557 | 1.781 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.135971 | 0.867 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.188174 | 0.725 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.051443 | 1.289 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.083338 | 1.079 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.135971 | 0.867 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.135971 | 0.867 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.125142 | 0.903 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.208179 | 0.682 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.125142 | 0.903 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.105871 | 0.975 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.067465 | 1.171 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.071863 | 1.143 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.091852 | 1.037 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.091852 | 1.037 |
| R-HSA-9707616 | Heme signaling | 0.020162 | 1.695 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.135971 | 0.867 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.135971 | 0.867 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.027566 | 1.560 |
| R-HSA-164843 | 2-LTR circle formation | 0.039577 | 1.403 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.045528 | 1.342 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.045528 | 1.342 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.054387 | 1.265 |
| R-HSA-420029 | Tight junction interactions | 0.091852 | 1.037 |
| R-HSA-68877 | Mitotic Prometaphase | 0.140652 | 0.852 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.043830 | 1.358 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.013263 | 1.877 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.108650 | 0.964 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.167675 | 0.776 |
| R-HSA-9843745 | Adipogenesis | 0.076567 | 1.116 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.077618 | 1.110 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.172847 | 0.762 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.193221 | 0.714 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.098944 | 1.005 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.116934 | 0.932 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.117799 | 0.929 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.048490 | 1.314 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.048490 | 1.314 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.048490 | 1.314 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.066073 | 1.180 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.114181 | 0.942 |
| R-HSA-75153 | Apoptotic execution phase | 0.012381 | 1.907 |
| R-HSA-1566948 | Elastic fibre formation | 0.130573 | 0.884 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.135971 | 0.867 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.048317 | 1.316 |
| R-HSA-5578775 | Ion homeostasis | 0.180546 | 0.743 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.151968 | 0.818 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.151342 | 0.820 |
| R-HSA-5689877 | Josephin domain DUBs | 0.039577 | 1.403 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.063165 | 1.200 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.091852 | 1.037 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.144006 | 0.842 |
| R-HSA-1221632 | Meiotic synapsis | 0.172847 | 0.762 |
| R-HSA-8951664 | Neddylation | 0.172076 | 0.764 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.039577 | 1.403 |
| R-HSA-9909396 | Circadian clock | 0.077463 | 1.111 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.149322 | 0.826 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.190702 | 0.720 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.103817 | 0.984 |
| R-HSA-4839726 | Chromatin organization | 0.051132 | 1.291 |
| R-HSA-397014 | Muscle contraction | 0.162191 | 0.790 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.103085 | 0.987 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.162471 | 0.789 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.170265 | 0.769 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.172847 | 0.762 |
| R-HSA-73894 | DNA Repair | 0.114064 | 0.943 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.111419 | 0.953 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.033590 | 1.474 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.144006 | 0.842 |
| R-HSA-109581 | Apoptosis | 0.107762 | 0.968 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.130369 | 0.885 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.090654 | 1.043 |
| R-HSA-373755 | Semaphorin interactions | 0.020702 | 1.684 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.083338 | 1.079 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.114181 | 0.942 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.114181 | 0.942 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.151968 | 0.818 |
| R-HSA-437239 | Recycling pathway of L1 | 0.157236 | 0.803 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.044441 | 1.352 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.146668 | 0.834 |
| R-HSA-112043 | PLC beta mediated events | 0.193221 | 0.714 |
| R-HSA-1280218 | Adaptive Immune System | 0.111589 | 0.952 |
| R-HSA-1640170 | Cell Cycle | 0.189774 | 0.722 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.044566 | 1.351 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.180546 | 0.743 |
| R-HSA-5357801 | Programmed Cell Death | 0.154581 | 0.811 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.162471 | 0.789 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.162471 | 0.789 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.195733 | 0.708 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.185639 | 0.731 |
| R-HSA-112040 | G-protein mediated events | 0.208179 | 0.682 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.190702 | 0.720 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.190702 | 0.720 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.190702 | 0.720 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.190702 | 0.720 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.179834 | 0.745 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.105784 | 0.976 |
| R-HSA-2028269 | Signaling by Hippo | 0.066073 | 1.180 |
| R-HSA-74160 | Gene expression (Transcription) | 0.039168 | 1.407 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.052964 | 1.276 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.052964 | 1.276 |
| R-HSA-597592 | Post-translational protein modification | 0.145510 | 0.837 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.111419 | 0.953 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.190702 | 0.720 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.183096 | 0.737 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.041066 | 1.387 |
| R-HSA-421270 | Cell-cell junction organization | 0.205681 | 0.687 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.017208 | 1.764 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.035948 | 1.444 |
| R-HSA-212436 | Generic Transcription Pathway | 0.051194 | 1.291 |
| R-HSA-5688426 | Deubiquitination | 0.210222 | 0.677 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.213635 | 0.670 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.215555 | 0.666 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.215555 | 0.666 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.215555 | 0.666 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.217999 | 0.662 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.222865 | 0.652 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.222865 | 0.652 |
| R-HSA-4086398 | Ca2+ pathway | 0.222865 | 0.652 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.225050 | 0.648 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.225286 | 0.647 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.225286 | 0.647 |
| R-HSA-380287 | Centrosome maturation | 0.227700 | 0.643 |
| R-HSA-8852135 | Protein ubiquitination | 0.227700 | 0.643 |
| R-HSA-5689603 | UCH proteinases | 0.230107 | 0.638 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.230107 | 0.638 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.230107 | 0.638 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.231847 | 0.635 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.232506 | 0.634 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.234898 | 0.629 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.234898 | 0.629 |
| R-HSA-446728 | Cell junction organization | 0.236516 | 0.626 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.242031 | 0.616 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.242031 | 0.616 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.244394 | 0.612 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.246750 | 0.608 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.249098 | 0.604 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.249098 | 0.604 |
| R-HSA-1500620 | Meiosis | 0.251439 | 0.600 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.253774 | 0.596 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.253774 | 0.596 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.260734 | 0.584 |
| R-HSA-9679506 | SARS-CoV Infections | 0.265225 | 0.576 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.265338 | 0.576 |
| R-HSA-202424 | Downstream TCR signaling | 0.265338 | 0.576 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.267630 | 0.572 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.272192 | 0.565 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.274463 | 0.562 |
| R-HSA-1500931 | Cell-Cell communication | 0.280315 | 0.552 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.283477 | 0.547 |
| R-HSA-9824446 | Viral Infection Pathways | 0.283576 | 0.547 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.284929 | 0.545 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.287943 | 0.541 |
| R-HSA-422356 | Regulation of insulin secretion | 0.287943 | 0.541 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.292381 | 0.534 |
| R-HSA-111885 | Opioid Signalling | 0.301177 | 0.521 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.303359 | 0.518 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.303359 | 0.518 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.305534 | 0.515 |
| R-HSA-418346 | Platelet homeostasis | 0.307703 | 0.512 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.310257 | 0.508 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.314170 | 0.503 |
| R-HSA-202403 | TCR signaling | 0.316312 | 0.500 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.318287 | 0.497 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.324816 | 0.488 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.326926 | 0.486 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.331126 | 0.480 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.331126 | 0.480 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.331126 | 0.480 |
| R-HSA-373760 | L1CAM interactions | 0.333216 | 0.477 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.335300 | 0.475 |
| R-HSA-5693538 | Homology Directed Repair | 0.337378 | 0.472 |
| R-HSA-392499 | Metabolism of proteins | 0.338582 | 0.470 |
| R-HSA-162582 | Signal Transduction | 0.342877 | 0.465 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.343573 | 0.464 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 0.347671 | 0.459 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.349711 | 0.456 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.353772 | 0.451 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.353772 | 0.451 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.353772 | 0.451 |
| R-HSA-194138 | Signaling by VEGF | 0.353772 | 0.451 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.355793 | 0.449 |
| R-HSA-68886 | M Phase | 0.356968 | 0.447 |
| R-HSA-69481 | G2/M Checkpoints | 0.357807 | 0.446 |
| R-HSA-1474165 | Reproduction | 0.365805 | 0.437 |
| R-HSA-5576891 | Cardiac conduction | 0.367789 | 0.434 |
| R-HSA-9717189 | Sensory perception of taste | 0.367789 | 0.434 |
| R-HSA-163685 | Integration of energy metabolism | 0.379567 | 0.421 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.379567 | 0.421 |
| R-HSA-6807070 | PTEN Regulation | 0.385375 | 0.414 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.396832 | 0.401 |
| R-HSA-2262752 | Cellular responses to stress | 0.404914 | 0.393 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.408079 | 0.389 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.408079 | 0.389 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.409933 | 0.387 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.415463 | 0.381 |
| R-HSA-1989781 | PPARA activates gene expression | 0.417294 | 0.380 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.420941 | 0.376 |
| R-HSA-162587 | HIV Life Cycle | 0.420941 | 0.376 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.426369 | 0.370 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.433529 | 0.363 |
| R-HSA-5663205 | Infectious disease | 0.442268 | 0.354 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.451048 | 0.346 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.451048 | 0.346 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.451048 | 0.346 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.451048 | 0.346 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.452771 | 0.344 |
| R-HSA-2559583 | Cellular Senescence | 0.462995 | 0.334 |
| R-HSA-69275 | G2/M Transition | 0.473031 | 0.325 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.476336 | 0.322 |
| R-HSA-5617833 | Cilium Assembly | 0.479620 | 0.319 |
| R-HSA-9609690 | HCMV Early Events | 0.489352 | 0.310 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.489352 | 0.310 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.494053 | 0.306 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.517490 | 0.286 |
| R-HSA-68882 | Mitotic Anaphase | 0.522029 | 0.282 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.523533 | 0.281 |
| R-HSA-418990 | Adherens junctions interactions | 0.525032 | 0.280 |
| R-HSA-422475 | Axon guidance | 0.528488 | 0.277 |
| R-HSA-162906 | HIV Infection | 0.538319 | 0.269 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.541222 | 0.267 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.548366 | 0.261 |
| R-HSA-15869 | Metabolism of nucleotides | 0.551241 | 0.259 |
| R-HSA-157118 | Signaling by NOTCH | 0.556870 | 0.254 |
| R-HSA-9675108 | Nervous system development | 0.563128 | 0.249 |
| R-HSA-9609646 | HCMV Infection | 0.570641 | 0.244 |
| R-HSA-416476 | G alpha (q) signalling events | 0.589218 | 0.230 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.590771 | 0.229 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.602003 | 0.220 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.608248 | 0.216 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.610719 | 0.214 |
| R-HSA-9658195 | Leishmania infection | 0.610719 | 0.214 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.627594 | 0.202 |
| R-HSA-195721 | Signaling by WNT | 0.631116 | 0.200 |
| R-HSA-1474244 | Extracellular matrix organization | 0.667765 | 0.175 |
| R-HSA-1643685 | Disease | 0.681840 | 0.166 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.699885 | 0.155 |
| R-HSA-418594 | G alpha (i) signalling events | 0.739961 | 0.131 |
| R-HSA-1266738 | Developmental Biology | 0.747178 | 0.127 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.752116 | 0.124 |
| R-HSA-72766 | Translation | 0.757596 | 0.121 |
| R-HSA-199991 | Membrane Trafficking | 0.880165 | 0.055 |
| R-HSA-168256 | Immune System | 0.886410 | 0.052 |
| R-HSA-388396 | GPCR downstream signalling | 0.920460 | 0.036 |
| R-HSA-109582 | Hemostasis | 0.923017 | 0.035 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.928830 | 0.032 |
| R-HSA-168249 | Innate Immune System | 0.930024 | 0.032 |
| R-HSA-8953854 | Metabolism of RNA | 0.934855 | 0.029 |
| R-HSA-372790 | Signaling by GPCR | 0.939393 | 0.027 |
| R-HSA-9709957 | Sensory Perception | 0.982873 | 0.008 |
| R-HSA-556833 | Metabolism of lipids | 0.992699 | 0.003 |
| R-HSA-1430728 | Metabolism | 0.999785 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.743 | 0.146 | 2 | 0.581 |
PRKD1 |
0.733 | 0.133 | -3 | 0.720 |
NDR2 |
0.732 | 0.092 | -3 | 0.723 |
GRK1 |
0.731 | 0.160 | -2 | 0.740 |
CAMK2G |
0.731 | 0.149 | 2 | 0.679 |
MOS |
0.731 | 0.146 | 1 | 0.711 |
CAMK2B |
0.730 | 0.176 | 2 | 0.685 |
CAMK2D |
0.729 | 0.168 | -3 | 0.710 |
CAMK2A |
0.729 | 0.191 | 2 | 0.693 |
PIM3 |
0.729 | 0.072 | -3 | 0.696 |
LATS2 |
0.728 | 0.105 | -5 | 0.612 |
CDC7 |
0.727 | -0.014 | 1 | 0.684 |
MAPKAPK2 |
0.724 | 0.094 | -3 | 0.584 |
CLK3 |
0.724 | 0.052 | 1 | 0.663 |
PRPK |
0.722 | -0.056 | -1 | 0.741 |
ATR |
0.722 | 0.054 | 1 | 0.736 |
PRKD2 |
0.722 | 0.070 | -3 | 0.635 |
PIM1 |
0.720 | 0.078 | -3 | 0.620 |
DSTYK |
0.720 | 0.021 | 2 | 0.588 |
NEK6 |
0.720 | 0.035 | -2 | 0.774 |
GCN2 |
0.720 | -0.069 | 2 | 0.564 |
ERK5 |
0.720 | 0.034 | 1 | 0.708 |
SRPK1 |
0.719 | 0.041 | -3 | 0.616 |
CDKL1 |
0.719 | 0.019 | -3 | 0.673 |
CDKL5 |
0.719 | 0.032 | -3 | 0.672 |
MAPKAPK3 |
0.719 | 0.049 | -3 | 0.637 |
CAMK1B |
0.719 | -0.005 | -3 | 0.713 |
WNK1 |
0.718 | 0.009 | -2 | 0.769 |
PDHK4 |
0.718 | -0.127 | 1 | 0.696 |
SKMLCK |
0.717 | 0.015 | -2 | 0.753 |
TGFBR2 |
0.717 | 0.004 | -2 | 0.737 |
RSK2 |
0.717 | 0.013 | -3 | 0.640 |
BMPR2 |
0.717 | -0.029 | -2 | 0.790 |
NDR1 |
0.717 | 0.003 | -3 | 0.690 |
RIPK3 |
0.716 | -0.046 | 3 | 0.538 |
TSSK1 |
0.716 | 0.027 | -3 | 0.738 |
FAM20C |
0.716 | 0.008 | 2 | 0.431 |
CHAK2 |
0.715 | -0.012 | -1 | 0.762 |
ULK2 |
0.715 | -0.106 | 2 | 0.507 |
AMPKA1 |
0.715 | -0.012 | -3 | 0.705 |
PKN3 |
0.715 | 0.001 | -3 | 0.679 |
TBK1 |
0.715 | -0.078 | 1 | 0.593 |
NLK |
0.715 | -0.050 | 1 | 0.665 |
IKKB |
0.714 | -0.059 | -2 | 0.633 |
ICK |
0.714 | 0.034 | -3 | 0.713 |
NEK7 |
0.714 | -0.062 | -3 | 0.772 |
PDHK1 |
0.713 | -0.118 | 1 | 0.688 |
MTOR |
0.713 | -0.103 | 1 | 0.633 |
HIPK4 |
0.713 | 0.008 | 1 | 0.657 |
P90RSK |
0.713 | -0.004 | -3 | 0.644 |
MASTL |
0.712 | -0.060 | -2 | 0.726 |
GRK5 |
0.712 | -0.051 | -3 | 0.722 |
TSSK2 |
0.712 | 0.021 | -5 | 0.806 |
IKKA |
0.712 | 0.001 | -2 | 0.638 |
NIK |
0.711 | -0.033 | -3 | 0.733 |
DNAPK |
0.710 | 0.117 | 1 | 0.636 |
IKKE |
0.710 | -0.083 | 1 | 0.580 |
RAF1 |
0.710 | -0.129 | 1 | 0.687 |
MLK2 |
0.710 | 0.019 | 2 | 0.515 |
MARK4 |
0.710 | -0.059 | 4 | 0.569 |
TGFBR1 |
0.709 | 0.073 | -2 | 0.764 |
AMPKA2 |
0.709 | -0.014 | -3 | 0.671 |
ATM |
0.709 | 0.043 | 1 | 0.698 |
BCKDK |
0.709 | -0.076 | -1 | 0.702 |
DAPK2 |
0.709 | -0.033 | -3 | 0.734 |
CAMLCK |
0.709 | -0.039 | -2 | 0.718 |
KIS |
0.709 | 0.001 | 1 | 0.543 |
CHK1 |
0.709 | 0.101 | -3 | 0.692 |
PKCD |
0.708 | -0.005 | 2 | 0.479 |
GRK6 |
0.708 | -0.035 | 1 | 0.692 |
GRK4 |
0.708 | -0.025 | -2 | 0.773 |
ULK1 |
0.707 | -0.102 | -3 | 0.714 |
MLK1 |
0.707 | -0.105 | 2 | 0.481 |
PKACG |
0.707 | -0.022 | -2 | 0.621 |
BMPR1B |
0.707 | 0.069 | 1 | 0.655 |
NUAK2 |
0.707 | -0.054 | -3 | 0.679 |
RIPK1 |
0.707 | -0.078 | 1 | 0.707 |
AURC |
0.706 | 0.010 | -2 | 0.535 |
ALK4 |
0.706 | 0.042 | -2 | 0.774 |
ANKRD3 |
0.706 | -0.036 | 1 | 0.728 |
PKN2 |
0.706 | -0.043 | -3 | 0.670 |
SRPK2 |
0.706 | 0.009 | -3 | 0.537 |
GRK7 |
0.705 | 0.050 | 1 | 0.637 |
LATS1 |
0.705 | 0.029 | -3 | 0.753 |
HUNK |
0.705 | -0.116 | 2 | 0.553 |
MELK |
0.705 | -0.015 | -3 | 0.658 |
RSK3 |
0.705 | -0.038 | -3 | 0.627 |
MST4 |
0.705 | -0.072 | 2 | 0.532 |
PRKD3 |
0.705 | 0.029 | -3 | 0.601 |
IRE1 |
0.704 | -0.067 | 1 | 0.698 |
MSK1 |
0.704 | 0.018 | -3 | 0.602 |
SRPK3 |
0.704 | 0.011 | -3 | 0.583 |
DLK |
0.704 | -0.064 | 1 | 0.677 |
MPSK1 |
0.704 | 0.143 | 1 | 0.707 |
MNK2 |
0.704 | -0.012 | -2 | 0.658 |
NEK9 |
0.703 | -0.110 | 2 | 0.540 |
RSK4 |
0.703 | 0.015 | -3 | 0.615 |
IRE2 |
0.703 | -0.046 | 2 | 0.446 |
TTBK2 |
0.703 | -0.091 | 2 | 0.456 |
PKCA |
0.703 | -0.006 | 2 | 0.405 |
WNK3 |
0.703 | -0.181 | 1 | 0.683 |
SMG1 |
0.702 | 0.010 | 1 | 0.711 |
NUAK1 |
0.702 | -0.029 | -3 | 0.634 |
CDK7 |
0.702 | -0.015 | 1 | 0.516 |
CDK1 |
0.702 | 0.006 | 1 | 0.480 |
CDK8 |
0.701 | -0.027 | 1 | 0.509 |
MSK2 |
0.701 | -0.024 | -3 | 0.608 |
MLK3 |
0.701 | -0.029 | 2 | 0.417 |
CAMK4 |
0.701 | -0.054 | -3 | 0.654 |
PKR |
0.700 | -0.037 | 1 | 0.726 |
PKCB |
0.700 | -0.027 | 2 | 0.415 |
P70S6KB |
0.699 | -0.048 | -3 | 0.644 |
DYRK2 |
0.699 | -0.018 | 1 | 0.589 |
PAK6 |
0.699 | 0.004 | -2 | 0.546 |
QSK |
0.699 | -0.052 | 4 | 0.565 |
MLK4 |
0.699 | -0.045 | 2 | 0.418 |
TLK2 |
0.699 | 0.010 | 1 | 0.668 |
ALK2 |
0.699 | 0.050 | -2 | 0.772 |
PLK1 |
0.699 | -0.053 | -2 | 0.719 |
PLK4 |
0.699 | -0.030 | 2 | 0.418 |
CDK18 |
0.699 | -0.001 | 1 | 0.471 |
PKACB |
0.699 | 0.020 | -2 | 0.555 |
PASK |
0.698 | 0.085 | -3 | 0.728 |
PRKX |
0.698 | 0.042 | -3 | 0.519 |
PAK1 |
0.698 | -0.054 | -2 | 0.649 |
NIM1 |
0.698 | -0.124 | 3 | 0.526 |
PKCZ |
0.698 | -0.040 | 2 | 0.459 |
CDK19 |
0.697 | -0.024 | 1 | 0.481 |
ACVR2B |
0.697 | 0.029 | -2 | 0.731 |
VRK2 |
0.697 | -0.092 | 1 | 0.742 |
CDK5 |
0.697 | -0.016 | 1 | 0.542 |
ACVR2A |
0.696 | 0.017 | -2 | 0.719 |
PKCG |
0.696 | -0.046 | 2 | 0.401 |
PAK3 |
0.696 | -0.072 | -2 | 0.641 |
PHKG1 |
0.696 | -0.062 | -3 | 0.672 |
PKG2 |
0.695 | -0.017 | -2 | 0.548 |
GSK3B |
0.695 | -0.016 | 4 | 0.318 |
PLK3 |
0.695 | -0.055 | 2 | 0.571 |
GSK3A |
0.695 | 0.008 | 4 | 0.318 |
MNK1 |
0.694 | -0.034 | -2 | 0.661 |
DCAMKL1 |
0.694 | -0.021 | -3 | 0.623 |
JNK2 |
0.694 | 0.008 | 1 | 0.467 |
AURB |
0.694 | -0.031 | -2 | 0.531 |
SIK |
0.694 | -0.057 | -3 | 0.604 |
CDK3 |
0.694 | 0.011 | 1 | 0.436 |
IRAK4 |
0.693 | -0.054 | 1 | 0.717 |
CDK13 |
0.693 | -0.043 | 1 | 0.497 |
HIPK2 |
0.693 | 0.003 | 1 | 0.498 |
CAMK1G |
0.693 | -0.028 | -3 | 0.603 |
PERK |
0.693 | -0.060 | -2 | 0.750 |
QIK |
0.692 | -0.111 | -3 | 0.696 |
CHAK1 |
0.692 | -0.118 | 2 | 0.450 |
P38B |
0.692 | -0.002 | 1 | 0.515 |
BRSK2 |
0.692 | -0.088 | -3 | 0.665 |
CLK1 |
0.692 | -0.029 | -3 | 0.582 |
NEK2 |
0.692 | -0.096 | 2 | 0.499 |
MAPKAPK5 |
0.692 | -0.046 | -3 | 0.580 |
PKCH |
0.691 | -0.078 | 2 | 0.399 |
CDK17 |
0.691 | -0.019 | 1 | 0.415 |
PIM2 |
0.691 | 0.002 | -3 | 0.597 |
JNK3 |
0.691 | -0.011 | 1 | 0.500 |
CLK2 |
0.691 | -0.004 | -3 | 0.589 |
CLK4 |
0.691 | -0.039 | -3 | 0.604 |
MARK3 |
0.691 | -0.071 | 4 | 0.518 |
MARK2 |
0.691 | -0.076 | 4 | 0.498 |
MEK1 |
0.691 | -0.136 | 2 | 0.566 |
YSK4 |
0.690 | -0.093 | 1 | 0.615 |
HIPK1 |
0.690 | -0.007 | 1 | 0.601 |
MYLK4 |
0.690 | -0.048 | -2 | 0.645 |
AKT2 |
0.690 | -0.008 | -3 | 0.538 |
WNK4 |
0.690 | -0.077 | -2 | 0.764 |
CAMK1D |
0.690 | 0.010 | -3 | 0.536 |
BRSK1 |
0.690 | -0.073 | -3 | 0.637 |
NEK5 |
0.689 | -0.017 | 1 | 0.727 |
P38A |
0.689 | -0.026 | 1 | 0.575 |
CDK2 |
0.689 | -0.042 | 1 | 0.562 |
CK2A2 |
0.688 | 0.047 | 1 | 0.544 |
PAK2 |
0.688 | -0.089 | -2 | 0.631 |
TLK1 |
0.688 | -0.013 | -2 | 0.780 |
BRAF |
0.688 | 0.002 | -4 | 0.747 |
MAK |
0.687 | 0.071 | -2 | 0.650 |
ERK1 |
0.687 | -0.028 | 1 | 0.502 |
BUB1 |
0.687 | 0.124 | -5 | 0.812 |
GRK2 |
0.687 | -0.046 | -2 | 0.660 |
HRI |
0.687 | -0.117 | -2 | 0.753 |
SGK3 |
0.686 | -0.036 | -3 | 0.607 |
CDK9 |
0.686 | -0.056 | 1 | 0.511 |
SSTK |
0.686 | -0.048 | 4 | 0.557 |
DCAMKL2 |
0.686 | -0.046 | -3 | 0.649 |
CDK12 |
0.686 | -0.047 | 1 | 0.470 |
MEKK1 |
0.686 | -0.104 | 1 | 0.675 |
GAK |
0.685 | 0.092 | 1 | 0.767 |
BMPR1A |
0.685 | 0.013 | 1 | 0.629 |
DYRK4 |
0.685 | -0.021 | 1 | 0.501 |
HIPK3 |
0.685 | -0.028 | 1 | 0.590 |
CDK16 |
0.685 | -0.010 | 1 | 0.436 |
ZAK |
0.684 | -0.093 | 1 | 0.630 |
IRAK1 |
0.684 | -0.128 | -1 | 0.701 |
DYRK1A |
0.684 | -0.040 | 1 | 0.576 |
MARK1 |
0.683 | -0.099 | 4 | 0.534 |
CDK14 |
0.683 | -0.028 | 1 | 0.511 |
PKACA |
0.683 | -0.010 | -2 | 0.503 |
SNRK |
0.683 | -0.153 | 2 | 0.425 |
ERK2 |
0.683 | -0.061 | 1 | 0.529 |
PRP4 |
0.683 | -0.040 | -3 | 0.634 |
PKCT |
0.682 | -0.068 | 2 | 0.419 |
PAK4 |
0.682 | -0.022 | -2 | 0.513 |
P38G |
0.681 | -0.033 | 1 | 0.409 |
CDK10 |
0.681 | -0.025 | 1 | 0.499 |
DRAK1 |
0.681 | -0.111 | 1 | 0.627 |
LKB1 |
0.681 | 0.037 | -3 | 0.739 |
SMMLCK |
0.680 | -0.054 | -3 | 0.669 |
MEK5 |
0.680 | -0.173 | 2 | 0.527 |
PAK5 |
0.680 | -0.040 | -2 | 0.500 |
CK1E |
0.680 | -0.031 | -3 | 0.408 |
AURA |
0.680 | -0.060 | -2 | 0.509 |
MEKK2 |
0.679 | -0.097 | 2 | 0.513 |
PINK1 |
0.679 | -0.115 | 1 | 0.683 |
CK2A1 |
0.678 | 0.029 | 1 | 0.521 |
MST3 |
0.678 | -0.084 | 2 | 0.496 |
DYRK1B |
0.678 | -0.041 | 1 | 0.521 |
PLK2 |
0.678 | -0.026 | -3 | 0.647 |
MEKK3 |
0.678 | -0.137 | 1 | 0.658 |
CAMK1A |
0.678 | 0.014 | -3 | 0.487 |
CK1D |
0.677 | -0.012 | -3 | 0.358 |
AKT1 |
0.676 | -0.026 | -3 | 0.551 |
TTBK1 |
0.676 | -0.124 | 2 | 0.392 |
DAPK3 |
0.676 | -0.034 | -3 | 0.637 |
TAO3 |
0.676 | -0.078 | 1 | 0.634 |
AKT3 |
0.675 | 0.019 | -3 | 0.482 |
CAMKK2 |
0.675 | -0.021 | -2 | 0.624 |
PBK |
0.675 | 0.085 | 1 | 0.730 |
P70S6K |
0.675 | -0.065 | -3 | 0.562 |
DYRK3 |
0.675 | -0.046 | 1 | 0.613 |
GRK3 |
0.675 | -0.047 | -2 | 0.635 |
CAMKK1 |
0.674 | -0.069 | -2 | 0.635 |
PKCI |
0.674 | -0.086 | 2 | 0.415 |
P38D |
0.674 | -0.034 | 1 | 0.450 |
MOK |
0.673 | 0.016 | 1 | 0.663 |
CK1A2 |
0.673 | -0.033 | -3 | 0.354 |
PKCE |
0.673 | -0.059 | 2 | 0.384 |
ERK7 |
0.673 | -0.049 | 2 | 0.266 |
EEF2K |
0.673 | -0.055 | 3 | 0.640 |
BIKE |
0.672 | 0.128 | 1 | 0.717 |
GCK |
0.671 | -0.026 | 1 | 0.638 |
PHKG2 |
0.671 | -0.128 | -3 | 0.621 |
JNK1 |
0.671 | -0.031 | 1 | 0.456 |
CHK2 |
0.670 | -0.024 | -3 | 0.470 |
CDK6 |
0.670 | -0.036 | 1 | 0.495 |
SBK |
0.670 | 0.019 | -3 | 0.424 |
NEK4 |
0.670 | -0.089 | 1 | 0.675 |
HGK |
0.670 | -0.048 | 3 | 0.649 |
NEK11 |
0.670 | -0.138 | 1 | 0.628 |
TNIK |
0.670 | -0.019 | 3 | 0.634 |
MST2 |
0.670 | -0.072 | 1 | 0.661 |
MEKK6 |
0.669 | -0.100 | 1 | 0.658 |
MAP3K15 |
0.669 | -0.078 | 1 | 0.616 |
PDK1 |
0.669 | -0.082 | 1 | 0.659 |
MINK |
0.668 | -0.067 | 1 | 0.647 |
STK33 |
0.668 | -0.096 | 2 | 0.362 |
NEK1 |
0.668 | -0.068 | 1 | 0.697 |
TAO2 |
0.667 | -0.132 | 2 | 0.541 |
CK1G1 |
0.667 | -0.084 | -3 | 0.398 |
VRK1 |
0.667 | -0.107 | 2 | 0.552 |
DAPK1 |
0.667 | -0.051 | -3 | 0.619 |
PKN1 |
0.667 | -0.058 | -3 | 0.572 |
NEK8 |
0.667 | -0.146 | 2 | 0.495 |
TAK1 |
0.666 | -0.046 | 1 | 0.661 |
LRRK2 |
0.666 | -0.131 | 2 | 0.539 |
AAK1 |
0.664 | 0.152 | 1 | 0.649 |
TTK |
0.663 | -0.026 | -2 | 0.756 |
CDK4 |
0.663 | -0.054 | 1 | 0.463 |
MRCKA |
0.663 | -0.046 | -3 | 0.589 |
KHS1 |
0.663 | -0.039 | 1 | 0.635 |
DMPK1 |
0.662 | 0.007 | -3 | 0.582 |
ROCK2 |
0.662 | -0.038 | -3 | 0.627 |
SGK1 |
0.661 | -0.036 | -3 | 0.461 |
HPK1 |
0.660 | -0.081 | 1 | 0.625 |
MST1 |
0.660 | -0.090 | 1 | 0.645 |
MRCKB |
0.660 | -0.050 | -3 | 0.573 |
LOK |
0.660 | -0.094 | -2 | 0.633 |
KHS2 |
0.659 | -0.033 | 1 | 0.638 |
PKG1 |
0.658 | -0.053 | -2 | 0.462 |
NEK3 |
0.657 | -0.103 | 1 | 0.638 |
YANK3 |
0.656 | -0.067 | 2 | 0.247 |
CRIK |
0.656 | -0.012 | -3 | 0.564 |
HASPIN |
0.656 | -0.018 | -1 | 0.662 |
YSK1 |
0.656 | -0.117 | 2 | 0.498 |
PDHK3_TYR |
0.655 | 0.184 | 4 | 0.618 |
MEK2 |
0.655 | -0.197 | 2 | 0.547 |
OSR1 |
0.654 | -0.052 | 2 | 0.494 |
SLK |
0.654 | -0.097 | -2 | 0.592 |
RIPK2 |
0.653 | -0.211 | 1 | 0.586 |
MYO3B |
0.648 | -0.075 | 2 | 0.497 |
PDHK4_TYR |
0.648 | 0.135 | 2 | 0.617 |
EPHA6 |
0.648 | 0.105 | -1 | 0.788 |
TESK1_TYR |
0.645 | 0.054 | 3 | 0.640 |
ASK1 |
0.644 | -0.097 | 1 | 0.599 |
BMPR2_TYR |
0.644 | 0.091 | -1 | 0.796 |
ROCK1 |
0.644 | -0.071 | -3 | 0.581 |
EPHB4 |
0.643 | 0.059 | -1 | 0.743 |
MAP2K6_TYR |
0.643 | 0.052 | -1 | 0.764 |
ALPHAK3 |
0.642 | -0.070 | -1 | 0.666 |
PKMYT1_TYR |
0.642 | -0.061 | 3 | 0.602 |
MAP2K4_TYR |
0.641 | 0.019 | -1 | 0.743 |
TXK |
0.641 | 0.116 | 1 | 0.703 |
TNK2 |
0.641 | 0.049 | 3 | 0.536 |
LCK |
0.641 | 0.104 | -1 | 0.780 |
PDHK1_TYR |
0.640 | 0.072 | -1 | 0.770 |
MYO3A |
0.640 | -0.115 | 1 | 0.647 |
EPHA4 |
0.639 | 0.048 | 2 | 0.560 |
LIMK2_TYR |
0.639 | -0.004 | -3 | 0.778 |
CK1A |
0.638 | -0.059 | -3 | 0.276 |
MAP2K7_TYR |
0.638 | -0.072 | 2 | 0.595 |
ITK |
0.638 | 0.036 | -1 | 0.737 |
EPHB3 |
0.637 | 0.067 | -1 | 0.735 |
TYRO3 |
0.637 | -0.030 | 3 | 0.576 |
SRMS |
0.636 | 0.033 | 1 | 0.724 |
BLK |
0.636 | 0.076 | -1 | 0.773 |
TAO1 |
0.635 | -0.149 | 1 | 0.572 |
EPHB1 |
0.635 | 0.037 | 1 | 0.715 |
FGR |
0.635 | 0.019 | 1 | 0.759 |
HCK |
0.634 | 0.024 | -1 | 0.764 |
STLK3 |
0.634 | -0.122 | 1 | 0.596 |
RET |
0.634 | -0.063 | 1 | 0.678 |
EPHB2 |
0.634 | 0.035 | -1 | 0.725 |
YES1 |
0.633 | -0.026 | -1 | 0.749 |
EPHA7 |
0.633 | 0.046 | 2 | 0.543 |
FYN |
0.632 | 0.084 | -1 | 0.777 |
MST1R |
0.632 | -0.067 | 3 | 0.572 |
JAK3 |
0.632 | -0.001 | 1 | 0.644 |
FER |
0.632 | -0.042 | 1 | 0.749 |
PINK1_TYR |
0.631 | -0.164 | 1 | 0.690 |
EPHA1 |
0.631 | 0.016 | 3 | 0.547 |
ROS1 |
0.631 | -0.088 | 3 | 0.540 |
BMX |
0.630 | 0.022 | -1 | 0.648 |
DDR1 |
0.630 | -0.129 | 4 | 0.541 |
LIMK1_TYR |
0.629 | -0.142 | 2 | 0.565 |
JAK2 |
0.629 | -0.081 | 1 | 0.674 |
TYK2 |
0.629 | -0.134 | 1 | 0.683 |
EPHA3 |
0.629 | 0.014 | 2 | 0.545 |
AXL |
0.629 | -0.040 | 3 | 0.570 |
MERTK |
0.629 | -0.023 | 3 | 0.539 |
CSF1R |
0.628 | -0.093 | 3 | 0.557 |
FGFR2 |
0.628 | -0.058 | 3 | 0.593 |
ABL2 |
0.627 | -0.040 | -1 | 0.688 |
EPHA5 |
0.627 | 0.038 | 2 | 0.558 |
TEK |
0.627 | -0.048 | 3 | 0.540 |
INSRR |
0.626 | -0.056 | 3 | 0.541 |
TNK1 |
0.626 | -0.065 | 3 | 0.532 |
TNNI3K_TYR |
0.625 | -0.014 | 1 | 0.714 |
MET |
0.625 | -0.010 | 3 | 0.554 |
PDGFRB |
0.625 | -0.105 | 3 | 0.579 |
YANK2 |
0.625 | -0.084 | 2 | 0.249 |
TEC |
0.624 | -0.030 | -1 | 0.641 |
DDR2 |
0.623 | -0.053 | 3 | 0.550 |
EPHA8 |
0.623 | 0.037 | -1 | 0.752 |
PTK6 |
0.623 | -0.075 | -1 | 0.650 |
FGFR1 |
0.623 | -0.069 | 3 | 0.559 |
LYN |
0.623 | 0.011 | 3 | 0.506 |
KDR |
0.622 | -0.052 | 3 | 0.536 |
ABL1 |
0.622 | -0.074 | -1 | 0.679 |
PTK2 |
0.622 | 0.078 | -1 | 0.791 |
KIT |
0.621 | -0.088 | 3 | 0.578 |
SRC |
0.619 | -0.001 | -1 | 0.743 |
ERBB2 |
0.618 | -0.041 | 1 | 0.636 |
EPHA2 |
0.617 | 0.042 | -1 | 0.712 |
BTK |
0.617 | -0.125 | -1 | 0.684 |
FLT3 |
0.617 | -0.145 | 3 | 0.564 |
PDGFRA |
0.616 | -0.140 | 3 | 0.572 |
LTK |
0.616 | -0.091 | 3 | 0.513 |
FLT1 |
0.616 | -0.015 | -1 | 0.744 |
FRK |
0.616 | -0.049 | -1 | 0.740 |
PTK2B |
0.616 | -0.052 | -1 | 0.677 |
FGFR3 |
0.616 | -0.078 | 3 | 0.575 |
WEE1_TYR |
0.615 | -0.084 | -1 | 0.654 |
CK1G3 |
0.615 | -0.079 | -3 | 0.231 |
JAK1 |
0.614 | -0.108 | 1 | 0.619 |
ALK |
0.614 | -0.127 | 3 | 0.502 |
NEK10_TYR |
0.613 | -0.101 | 1 | 0.515 |
NTRK1 |
0.612 | -0.129 | -1 | 0.693 |
NTRK2 |
0.611 | -0.127 | 3 | 0.550 |
INSR |
0.611 | -0.121 | 3 | 0.515 |
EGFR |
0.611 | -0.030 | 1 | 0.563 |
NTRK3 |
0.611 | -0.059 | -1 | 0.647 |
ERBB4 |
0.611 | 0.023 | 1 | 0.591 |
SYK |
0.610 | 0.055 | -1 | 0.731 |
FLT4 |
0.608 | -0.125 | 3 | 0.536 |
CK1G2 |
0.605 | -0.052 | -3 | 0.315 |
FGFR4 |
0.604 | -0.070 | -1 | 0.653 |
CSK |
0.604 | -0.100 | 2 | 0.547 |
MATK |
0.604 | -0.096 | -1 | 0.607 |
IGF1R |
0.600 | -0.105 | 3 | 0.477 |
FES |
0.596 | -0.082 | -1 | 0.623 |
ZAP70 |
0.590 | 0.017 | -1 | 0.662 |
MUSK |
0.590 | -0.126 | 1 | 0.556 |