Motif 214 (n=126)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5D6W6 | FITM1 | S82 | ochoa | Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1) | Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity) (PubMed:18160536). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity). {ECO:0000255|HAMAP-Rule:MF_03229, ECO:0000269|PubMed:18160536}. |
| A8MVW0 | FAM171A2 | S410 | ochoa | Protein FAM171A2 | None |
| O00139 | KIF2A | S100 | ochoa|psp | Kinesin-like protein KIF2A (Kinesin-2) (hK2) | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:30785839}. |
| O00192 | ARVCF | S915 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14639 | ABLIM1 | S655 | ochoa | Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) | May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. {ECO:0000250, ECO:0000269|PubMed:9245787}. |
| O15117 | FYB1 | S46 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15417 | TNRC18 | S999 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43683 | BUB1 | S402 | psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60292 | SIPA1L3 | S1440 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60336 | MAPKBP1 | S1165 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O75385 | ULK1 | S783 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O95155 | UBE4B | S358 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95359 | TACC2 | S124 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95425 | SVIL | S905 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95613 | PCNT | S2195 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P05187 | ALPP | S177 | ochoa | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P07384 | CAPN1 | S470 | ochoa | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}. |
| P09923 | ALPI | S174 | ochoa | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
| P15923 | TCF3 | S157 | ochoa | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250|UniProtKB:P15806, ECO:0000269|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269|PubMed:31696227}. |
| P16083 | NQO2 | S83 | ochoa | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}. |
| P22314 | UBA1 | S820 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P22736 | NR4A1 | S23 | ochoa | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P27708 | CAD | S1859 | ochoa|psp | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P27815 | PDE4A | S128 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P31629 | HIVEP2 | S71 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P36507 | MAP2K2 | S30 | ochoa | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P42166 | TMPO | S272 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P43119 | PTGIR | S328 | psp | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| P48634 | PRRC2A | S146 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49326 | FMO5 | S54 | ochoa | Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1) | Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:20947616, PubMed:26771671, PubMed:28783300). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}. |
| P50851 | LRBA | S2201 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51610 | HCFC1 | S2007 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P53814 | SMTN | S322 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55196 | AFDN | S1236 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P56524 | HDAC4 | S246 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| Q00613 | HSF1 | S344 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q00978 | IRF9 | S283 | ochoa | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}. |
| Q08J23 | NSUN2 | S724 | ochoa | RNA cytosine C(5)-methyltransferase NSUN2 (EC 2.1.1.-) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (mRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-) (tRNA cytosine C(5)-methyltransferase) (EC 2.1.1.-, EC 2.1.1.203) (tRNA methyltransferase 4 homolog) (hTrm4) | RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:17071714, PubMed:22995836, PubMed:31199786, PubMed:31358969). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay (PubMed:31199786). Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (PubMed:17071714, PubMed:22995836, PubMed:31199786). tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs) (PubMed:31199786). Also mediates C(5)-methylation of mitochondrial tRNAs (PubMed:31276587). Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay: mRNA stabilization involves YBX1 that specifically recognizes and binds m5C-modified transcripts (PubMed:22395603, PubMed:31358969, PubMed:34556860). Cytosine C(5)-methylation of mRNAs also regulates mRNA export: methylated transcripts are specifically recognized by THOC4/ALYREF, which mediates mRNA nucleo-cytoplasmic shuttling (PubMed:28418038). Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs (PubMed:23871666). Cytosine C(5)-methylation of vtRNA VTRNA1.1 promotes its processing into small-vault RNA4 (svRNA4) and regulates epidermal differentiation (PubMed:31186410). May act downstream of Myc to regulate epidermal cell growth and proliferation (By similarity). Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (PubMed:19596847). {ECO:0000250|UniProtKB:Q1HFZ0, ECO:0000269|PubMed:17071714, ECO:0000269|PubMed:19596847, ECO:0000269|PubMed:22395603, ECO:0000269|PubMed:22995836, ECO:0000269|PubMed:23871666, ECO:0000269|PubMed:28418038, ECO:0000269|PubMed:31186410, ECO:0000269|PubMed:31199786, ECO:0000269|PubMed:31276587, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:34556860}. |
| Q0JRZ9 | FCHO2 | S468 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q13224 | GRIN2B | S1415 | psp | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q14137 | BOP1 | S598 | ochoa | Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03027, ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. |
| Q14674 | ESPL1 | S1528 | ochoa | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q15021 | NCAPD2 | S1333 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15654 | TRIP6 | S189 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q32MQ0 | ZNF750 | S360 | ochoa | Zinc finger protein 750 | Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression. {ECO:0000269|PubMed:22364861}. |
| Q5FWE3 | PRRT3 | S777 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5SY16 | NOL9 | S105 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T1M5 | FKBP15 | S1065 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T5P2 | KIAA1217 | S1702 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q5VSL9 | STRIP1 | S335 | ochoa | Striatin-interacting protein 1 (Protein FAM40A) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399}. |
| Q66K74 | MAP1S | S546 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q6AW86 | ZNF324B | S79 | ochoa | Zinc finger protein 324B | May be involved in transcriptional regulation. |
| Q6N043 | ZNF280D | S530 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6P4F7 | ARHGAP11A | S941 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6P5Z2 | PKN3 | S488 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q6PKG0 | LARP1 | S548 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6XZF7 | DNMBP | S458 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZNC4 | ZNF704 | S264 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
| Q765P7 | MTSS2 | S538 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q86TC9 | MYPN | S719 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86Y01 | DTX1 | S195 | ochoa | E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1) | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Q86YV5 | PRAG1 | Y159 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
| Q8IZT6 | ASPM | S570 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N350 | CBARP | S322 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3V7 | SYNPO | S787 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N6T3 | ARFGAP1 | S159 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NCD3 | HJURP | S185 | ochoa|psp | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NEZ4 | KMT2C | S46 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TAQ2 | SMARCC2 | S555 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TB72 | PUM2 | S182 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q8TBE0 | BAHD1 | S206 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
| Q8TBP0 | TBC1D16 | S155 | ochoa | TBC1 domain family member 16 | May act as a GTPase-activating protein for Rab family protein(s). |
| Q8TD55 | PLEKHO2 | S167 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDN4 | CABLES1 | S168 | ochoa | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TEC5 | SH3RF2 | S112 | ochoa | E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) | Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436). {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}. |
| Q8WUI4 | HDAC7 | S155 | ochoa|psp | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
| Q92619 | ARHGAP45 | S84 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92750 | TAF4B | S59 | ochoa | Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105) | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Q96BX8 | MOB3A | S38 | psp | MOB kinase activator 3A (MOB-LAK) (Mob1 homolog 2A) (Mps one binder kinase activator-like 2A) | May regulate the activity of kinases. {ECO:0000250}. |
| Q96KG9 | SCYL1 | S462 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q96QB1 | DLC1 | S991 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96QT6 | PHF12 | S780 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96SN8 | CDK5RAP2 | S1061 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q9BTX1 | NDC1 | S489 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9BW04 | SARG | S185 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BWF3 | RBM4 | S337 | ochoa | RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) | RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:12628928, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:16777844, ECO:0000269|PubMed:16934801, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:19801630, ECO:0000269|PubMed:21343338, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:37548402}. |
| Q9BY44 | EIF2A | Y446 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9BYB0 | SHANK3 | S375 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BYB0 | SHANK3 | S1121 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BYV9 | BACH2 | S337 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9H4M7 | PLEKHA4 | S194 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9NPG4 | PCDH12 | S859 | ochoa | Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form] | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250|UniProtKB:O55134, ECO:0000269|PubMed:21402705}. |
| Q9NPG4 | PCDH12 | S906 | ochoa | Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form] | Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250|UniProtKB:O55134, ECO:0000269|PubMed:21402705}. |
| Q9NQ75 | CASS4 | S165 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NSV4 | DIAPH3 | S26 | ochoa | Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2) | Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250|UniProtKB:Q9Z207}. |
| Q9NVZ3 | NECAP2 | S181 | ochoa | Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2) | Involved in endocytosis. {ECO:0000250}. |
| Q9NY61 | AATF | S61 | ochoa | Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272, ECO:0000269|PubMed:34516797}. |
| Q9NYL2 | MAP3K20 | S757 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NYV4 | CDK12 | S1200 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P227 | ARHGAP23 | S545 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UBW5 | BIN2 | S451 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UGU0 | TCF20 | S574 | ochoa | Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) | Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269|PubMed:10995766}. |
| Q9UHR5 | SAP30BP | S104 | ochoa | SAP30-binding protein (Transcriptional regulator protein HCNGP) | Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). May be involved in the regulation of beta-2-microglobulin genes (By similarity). {ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:21221920}.; FUNCTION: (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC. {ECO:0000269|PubMed:21221920}. |
| Q9UJY5 | GGA1 | S355 | psp | ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712, PubMed:15886016). {ECO:0000250|UniProtKB:Q8R0H9, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:15886016, ECO:0000269|PubMed:27901063}. |
| Q9UKV0 | HDAC9 | S220 | ochoa|psp | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULQ0 | STRIP2 | S318 | ochoa | Striatin-interacting protein 2 (Protein FAM40B) | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:21834987). Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:21834987}. |
| Q9ULU4 | ZMYND8 | S655 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UPN7 | PPP6R1 | S759 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Q9UQB8 | BAIAP2 | S261 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9UQL6 | HDAC5 | S259 | ochoa|psp | Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}. |
| Q9Y2K2 | SIK3 | S551 | psp | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) | Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q6P4S6, ECO:0000269|PubMed:30232230, ECO:0000305|PubMed:29211348}. |
| Q9Y2X7 | GIT1 | S498 | ochoa|psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y3Q8 | TSC22D4 | S370 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4H2 | IRS2 | S594 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4H2 | IRS2 | S1100 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4W6 | AFG3L2 | S50 | ochoa | Mitochondrial inner membrane m-AAA protease component AFG3L2 (EC 3.4.24.-) (EC 3.6.-.-) (AFG3-like protein 2) (Paraplegin-like protein) | Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development (PubMed:19748354, PubMed:28396416, PubMed:29932645, PubMed:30683687, PubMed:31327635, PubMed:37917749, PubMed:38157846). AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354, PubMed:31327635). The m-AAA protease carries out quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:26504172, PubMed:30683687, PubMed:34718584). The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7 (PubMed:22354088, PubMed:29932645, PubMed:30252181). Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:29932645). Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP) (PubMed:30252181). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048, PubMed:28396416). Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435). Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39 (PubMed:37917749, PubMed:38157846). SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur (PubMed:37917749, PubMed:38157846). Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:17615298, PubMed:29545505, PubMed:30252181, PubMed:30683687, PubMed:32600459). May act by mediating processing of OMA1 precursor, participating in OMA1 maturation (PubMed:29545505). {ECO:0000269|PubMed:17615298, ECO:0000269|PubMed:19748354, ECO:0000269|PubMed:22354088, ECO:0000269|PubMed:26504172, ECO:0000269|PubMed:27642048, ECO:0000269|PubMed:28396416, ECO:0000269|PubMed:29545505, ECO:0000269|PubMed:29932645, ECO:0000269|PubMed:30252181, ECO:0000269|PubMed:30683687, ECO:0000269|PubMed:31327635, ECO:0000269|PubMed:32600459, ECO:0000269|PubMed:34718584, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:37917749, ECO:0000269|PubMed:38157846}. |
| Q9Y6J0 | CABIN1 | S1473 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P04040 | CAT | Y358 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| O60566 | BUB1B | S318 | Sugiyama | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Q96B18 | DACT3 | S422 | Sugiyama | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q8NDV7 | TNRC6A | S1047 | Sugiyama | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| P10070 | GLI2 | S863 | SIGNOR | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| Q13459 | MYO9B | S1308 | Sugiyama | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| O43159 | RRP8 | S309 | Sugiyama | Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| P30305 | CDC25B | S219 | SIGNOR | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P51452 | DUSP3 | S43 | Sugiyama | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-350054 | Notch-HLH transcription pathway | 0.000107 | 3.972 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.000816 | 3.088 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.001693 | 2.771 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.001671 | 2.777 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001588 | 2.799 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.001517 | 2.819 |
| R-HSA-68877 | Mitotic Prometaphase | 0.002384 | 2.623 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.002940 | 2.532 |
| R-HSA-68886 | M Phase | 0.002478 | 2.606 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.002860 | 2.544 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.002860 | 2.544 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.002860 | 2.544 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.002860 | 2.544 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.002860 | 2.544 |
| R-HSA-68882 | Mitotic Anaphase | 0.004276 | 2.369 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.004374 | 2.359 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.008824 | 2.054 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.008824 | 2.054 |
| R-HSA-9646399 | Aggrephagy | 0.007794 | 2.108 |
| R-HSA-9663891 | Selective autophagy | 0.009813 | 2.008 |
| R-HSA-8854214 | TBC/RABGAPs | 0.009717 | 2.012 |
| R-HSA-1640170 | Cell Cycle | 0.009589 | 2.018 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.015378 | 1.813 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.014884 | 1.827 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.023210 | 1.634 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.023210 | 1.634 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.020241 | 1.694 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.020365 | 1.691 |
| R-HSA-162582 | Signal Transduction | 0.021615 | 1.665 |
| R-HSA-157118 | Signaling by NOTCH | 0.024396 | 1.613 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.025804 | 1.588 |
| R-HSA-9839394 | TGFBR3 expression | 0.029085 | 1.536 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.028854 | 1.540 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.027388 | 1.562 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.027388 | 1.562 |
| R-HSA-199991 | Membrane Trafficking | 0.028184 | 1.550 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.032438 | 1.489 |
| R-HSA-69275 | G2/M Transition | 0.031530 | 1.501 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.032600 | 1.487 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.030822 | 1.511 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.032666 | 1.486 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 0.049774 | 1.303 |
| R-HSA-74713 | IRS activation | 0.057828 | 1.238 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.057828 | 1.238 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.065813 | 1.182 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.073731 | 1.132 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 0.081583 | 1.088 |
| R-HSA-112412 | SOS-mediated signalling | 0.081583 | 1.088 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.081583 | 1.088 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.089369 | 1.049 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.097089 | 1.013 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.104744 | 0.980 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.112334 | 0.949 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.119861 | 0.921 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.127324 | 0.895 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.134725 | 0.871 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.134725 | 0.871 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.142063 | 0.848 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.149340 | 0.826 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.149340 | 0.826 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.149340 | 0.826 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.163709 | 0.786 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.184813 | 0.733 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.191730 | 0.717 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.191730 | 0.717 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.198588 | 0.702 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.205388 | 0.687 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.205388 | 0.687 |
| R-HSA-380287 | Centrosome maturation | 0.034481 | 1.462 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.218818 | 0.660 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.050591 | 1.296 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.257769 | 0.589 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.257769 | 0.589 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.264071 | 0.578 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.270319 | 0.568 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.270319 | 0.568 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.282659 | 0.549 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.282659 | 0.549 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.288751 | 0.539 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.300781 | 0.522 |
| R-HSA-3371511 | HSF1 activation | 0.306720 | 0.513 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.324239 | 0.489 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.329980 | 0.482 |
| R-HSA-3371568 | Attenuation phase | 0.329980 | 0.482 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.329980 | 0.482 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.053144 | 1.275 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.104744 | 0.980 |
| R-HSA-198203 | PI3K/AKT activation | 0.104744 | 0.980 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.312609 | 0.505 |
| R-HSA-3371556 | Cellular response to heat stress | 0.318927 | 0.496 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.065813 | 1.182 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.232022 | 0.634 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.232022 | 0.634 |
| R-HSA-4641265 | Repression of WNT target genes | 0.127324 | 0.895 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.057828 | 1.238 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.142063 | 0.848 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.163709 | 0.786 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.312609 | 0.505 |
| R-HSA-3928664 | Ephrin signaling | 0.177838 | 0.750 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 0.081583 | 1.088 |
| R-HSA-8949664 | Processing of SMDT1 | 0.134725 | 0.871 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.148821 | 0.827 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.172646 | 0.763 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.238540 | 0.622 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.249983 | 0.602 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.158479 | 0.800 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.041653 | 1.380 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 0.112334 | 0.949 |
| R-HSA-202670 | ERKs are inactivated | 0.119861 | 0.921 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 0.127324 | 0.895 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.245004 | 0.611 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.312609 | 0.505 |
| R-HSA-6798695 | Neutrophil degranulation | 0.114586 | 0.941 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.177838 | 0.750 |
| R-HSA-6807070 | PTEN Regulation | 0.148429 | 0.828 |
| R-HSA-74749 | Signal attenuation | 0.104744 | 0.980 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.184813 | 0.733 |
| R-HSA-9620244 | Long-term potentiation | 0.232022 | 0.634 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.238540 | 0.622 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.093113 | 1.031 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.288751 | 0.539 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.177838 | 0.750 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.249983 | 0.602 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.063961 | 1.194 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.137183 | 0.863 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.169259 | 0.771 |
| R-HSA-9612973 | Autophagy | 0.062182 | 1.206 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.065813 | 1.182 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.097089 | 1.013 |
| R-HSA-217271 | FMO oxidises nucleophiles | 0.119861 | 0.921 |
| R-HSA-159424 | Conjugation of carboxylic acids | 0.184813 | 0.733 |
| R-HSA-156587 | Amino Acid conjugation | 0.184813 | 0.733 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.044480 | 1.352 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.063961 | 1.194 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.038368 | 1.416 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.187837 | 0.726 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.132187 | 0.879 |
| R-HSA-1632852 | Macroautophagy | 0.046774 | 1.330 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.243710 | 0.613 |
| R-HSA-170968 | Frs2-mediated activation | 0.134725 | 0.871 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.106393 | 0.973 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.222529 | 0.653 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.205388 | 0.687 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.089369 | 1.049 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.104744 | 0.980 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.282659 | 0.549 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.294792 | 0.530 |
| R-HSA-5617833 | Cilium Assembly | 0.263133 | 0.580 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.286096 | 0.543 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.077893 | 1.109 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.097089 | 1.013 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.127324 | 0.895 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.205388 | 0.687 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.212131 | 0.673 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.218818 | 0.660 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.329980 | 0.482 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.329980 | 0.482 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.196498 | 0.707 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.300196 | 0.523 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.131444 | 0.881 |
| R-HSA-525793 | Myogenesis | 0.238540 | 0.622 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.282659 | 0.549 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.312609 | 0.505 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.215600 | 0.666 |
| R-HSA-169893 | Prolonged ERK activation events | 0.156555 | 0.805 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.328462 | 0.484 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.158693 | 0.799 |
| R-HSA-8964572 | Lipid particle organization | 0.073731 | 1.132 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.198588 | 0.702 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.238540 | 0.622 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.282659 | 0.549 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.318449 | 0.497 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.170803 | 0.768 |
| R-HSA-381042 | PERK regulates gene expression | 0.300781 | 0.522 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.197039 | 0.705 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.044066 | 1.356 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.097089 | 1.013 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.050280 | 1.299 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.177838 | 0.750 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.324239 | 0.489 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.300781 | 0.522 |
| R-HSA-4086398 | Ca2+ pathway | 0.151762 | 0.819 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.040014 | 1.398 |
| R-HSA-198753 | ERK/MAPK targets | 0.198588 | 0.702 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.205388 | 0.687 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.257769 | 0.589 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.096651 | 1.015 |
| R-HSA-9834899 | Specification of the neural plate border | 0.184813 | 0.733 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.114592 | 0.941 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.053220 | 1.274 |
| R-HSA-187687 | Signalling to ERKs | 0.300781 | 0.522 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.172646 | 0.763 |
| R-HSA-211000 | Gene Silencing by RNA | 0.268825 | 0.571 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.282659 | 0.549 |
| R-HSA-202433 | Generation of second messenger molecules | 0.329980 | 0.482 |
| R-HSA-68875 | Mitotic Prophase | 0.315812 | 0.501 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.101784 | 0.992 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.112334 | 0.949 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.200119 | 0.699 |
| R-HSA-74160 | Gene expression (Transcription) | 0.049024 | 1.310 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.234315 | 0.630 |
| R-HSA-2586552 | Signaling by Leptin | 0.104744 | 0.980 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.148821 | 0.827 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.054444 | 1.264 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.142063 | 0.848 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.309574 | 0.509 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.212869 | 0.672 |
| R-HSA-445144 | Signal transduction by L1 | 0.191730 | 0.717 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.123364 | 0.909 |
| R-HSA-5205647 | Mitophagy | 0.294792 | 0.530 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.149340 | 0.826 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.205388 | 0.687 |
| R-HSA-180024 | DARPP-32 events | 0.257769 | 0.589 |
| R-HSA-5673000 | RAF activation | 0.294792 | 0.530 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.120619 | 0.919 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.090932 | 1.041 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.049767 | 1.303 |
| R-HSA-1500931 | Cell-Cell communication | 0.320781 | 0.494 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.088100 | 1.055 |
| R-HSA-212436 | Generic Transcription Pathway | 0.044994 | 1.347 |
| R-HSA-166520 | Signaling by NTRKs | 0.054178 | 1.266 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.191730 | 0.717 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.256261 | 0.591 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.052417 | 1.281 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.257769 | 0.589 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.065889 | 1.181 |
| R-HSA-422475 | Axon guidance | 0.208335 | 0.681 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.218818 | 0.660 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.238540 | 0.622 |
| R-HSA-9675108 | Nervous system development | 0.254557 | 0.594 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.245004 | 0.611 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.264071 | 0.578 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.170803 | 0.768 |
| R-HSA-8853659 | RET signaling | 0.052417 | 1.281 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.232022 | 0.634 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.325146 | 0.488 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.218818 | 0.660 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.148429 | 0.828 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.312695 | 0.505 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.240576 | 0.619 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.193965 | 0.712 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.212494 | 0.673 |
| R-HSA-418990 | Adherens junctions interactions | 0.330092 | 0.481 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.335673 | 0.474 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.335673 | 0.474 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.335673 | 0.474 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.341318 | 0.467 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.341318 | 0.467 |
| R-HSA-167161 | HIV Transcription Initiation | 0.341318 | 0.467 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.341318 | 0.467 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.341318 | 0.467 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.341318 | 0.467 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.341318 | 0.467 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.341318 | 0.467 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.341318 | 0.467 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.352465 | 0.453 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.357968 | 0.446 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.357968 | 0.446 |
| R-HSA-373752 | Netrin-1 signaling | 0.357968 | 0.446 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.363425 | 0.440 |
| R-HSA-774815 | Nucleosome assembly | 0.363425 | 0.440 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.363425 | 0.440 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.363425 | 0.440 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.363425 | 0.440 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 0.363425 | 0.440 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.367142 | 0.435 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.368836 | 0.433 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.368836 | 0.433 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.368836 | 0.433 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.368836 | 0.433 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.368836 | 0.433 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.368836 | 0.433 |
| R-HSA-75153 | Apoptotic execution phase | 0.368836 | 0.433 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.368836 | 0.433 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.374282 | 0.427 |
| R-HSA-5620924 | Intraflagellar transport | 0.379521 | 0.421 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.380330 | 0.420 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.380462 | 0.420 |
| R-HSA-9664407 | Parasite infection | 0.386353 | 0.413 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.386353 | 0.413 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.386353 | 0.413 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.389355 | 0.410 |
| R-HSA-109704 | PI3K Cascade | 0.390026 | 0.409 |
| R-HSA-2262752 | Cellular responses to stress | 0.390694 | 0.408 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.395212 | 0.403 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.395341 | 0.403 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.395341 | 0.403 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.400355 | 0.398 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.400355 | 0.398 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.400355 | 0.398 |
| R-HSA-4839726 | Chromatin organization | 0.401573 | 0.396 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.405454 | 0.392 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.405454 | 0.392 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.405454 | 0.392 |
| R-HSA-421270 | Cell-cell junction organization | 0.406129 | 0.391 |
| R-HSA-72649 | Translation initiation complex formation | 0.410510 | 0.387 |
| R-HSA-69242 | S Phase | 0.413135 | 0.384 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.415523 | 0.381 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.415523 | 0.381 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.417474 | 0.379 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.420494 | 0.376 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.420494 | 0.376 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.420494 | 0.376 |
| R-HSA-8935690 | Digestion | 0.420494 | 0.376 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.420494 | 0.376 |
| R-HSA-75893 | TNF signaling | 0.420494 | 0.376 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.420494 | 0.376 |
| R-HSA-112399 | IRS-mediated signalling | 0.425423 | 0.371 |
| R-HSA-1483166 | Synthesis of PA | 0.425423 | 0.371 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.430311 | 0.366 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.430311 | 0.366 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.430311 | 0.366 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.430669 | 0.366 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.430669 | 0.366 |
| R-HSA-73887 | Death Receptor Signaling | 0.430669 | 0.366 |
| R-HSA-191859 | snRNP Assembly | 0.435157 | 0.361 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.435157 | 0.361 |
| R-HSA-9033241 | Peroxisomal protein import | 0.435157 | 0.361 |
| R-HSA-162587 | HIV Life Cycle | 0.439334 | 0.357 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.439962 | 0.357 |
| R-HSA-983189 | Kinesins | 0.439962 | 0.357 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.439962 | 0.357 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.444727 | 0.352 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.444727 | 0.352 |
| R-HSA-450294 | MAP kinase activation | 0.444727 | 0.352 |
| R-HSA-877300 | Interferon gamma signaling | 0.445070 | 0.352 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.447926 | 0.349 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.449451 | 0.347 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.449451 | 0.347 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.449451 | 0.347 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.449451 | 0.347 |
| R-HSA-913531 | Interferon Signaling | 0.450946 | 0.346 |
| R-HSA-109581 | Apoptosis | 0.453614 | 0.343 |
| R-HSA-8963743 | Digestion and absorption | 0.454136 | 0.343 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.458780 | 0.338 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.458780 | 0.338 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.463386 | 0.334 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.463386 | 0.334 |
| R-HSA-446728 | Cell junction organization | 0.466483 | 0.331 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.467953 | 0.330 |
| R-HSA-167172 | Transcription of the HIV genome | 0.476971 | 0.322 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.476971 | 0.322 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.478793 | 0.320 |
| R-HSA-72306 | tRNA processing | 0.478793 | 0.320 |
| R-HSA-418555 | G alpha (s) signalling events | 0.481547 | 0.317 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.485837 | 0.314 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.485837 | 0.314 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.485837 | 0.314 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.485837 | 0.314 |
| R-HSA-448424 | Interleukin-17 signaling | 0.485837 | 0.314 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.487029 | 0.312 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.487029 | 0.312 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.489757 | 0.310 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.490214 | 0.310 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.490214 | 0.310 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.490214 | 0.310 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.490214 | 0.310 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.490317 | 0.310 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.492475 | 0.308 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.494554 | 0.306 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.498858 | 0.302 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.498858 | 0.302 |
| R-HSA-9749641 | Aspirin ADME | 0.498858 | 0.302 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.503125 | 0.298 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.505217 | 0.297 |
| R-HSA-2559583 | Cellular Senescence | 0.505932 | 0.296 |
| R-HSA-8852135 | Protein ubiquitination | 0.507356 | 0.295 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.507356 | 0.295 |
| R-HSA-5689603 | UCH proteinases | 0.511551 | 0.291 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.515711 | 0.288 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.519835 | 0.284 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.519835 | 0.284 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.522347 | 0.282 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.526980 | 0.278 |
| R-HSA-9833482 | PKR-mediated signaling | 0.527980 | 0.277 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.532001 | 0.274 |
| R-HSA-977225 | Amyloid fiber formation | 0.532001 | 0.274 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.535987 | 0.271 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.536403 | 0.271 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.543860 | 0.265 |
| R-HSA-9609690 | HCMV Early Events | 0.547420 | 0.262 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.547420 | 0.262 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.547747 | 0.261 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.547747 | 0.261 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.551600 | 0.258 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.555421 | 0.255 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.555421 | 0.255 |
| R-HSA-5357801 | Programmed Cell Death | 0.572100 | 0.243 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.574047 | 0.241 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.581278 | 0.236 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.588388 | 0.230 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.588388 | 0.230 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.588792 | 0.230 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.605642 | 0.218 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.605642 | 0.218 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.605642 | 0.218 |
| R-HSA-3214847 | HATs acetylate histones | 0.609005 | 0.215 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.609005 | 0.215 |
| R-HSA-70171 | Glycolysis | 0.612341 | 0.213 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.612341 | 0.213 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.618926 | 0.208 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.618926 | 0.208 |
| R-HSA-1483255 | PI Metabolism | 0.618926 | 0.208 |
| R-HSA-162906 | HIV Infection | 0.622935 | 0.206 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.625132 | 0.204 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.625401 | 0.204 |
| R-HSA-111885 | Opioid Signalling | 0.625401 | 0.204 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.628597 | 0.202 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.628597 | 0.202 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.628597 | 0.202 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.630208 | 0.201 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.631767 | 0.199 |
| R-HSA-72312 | rRNA processing | 0.633823 | 0.198 |
| R-HSA-418346 | Platelet homeostasis | 0.634909 | 0.197 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.641114 | 0.193 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.641114 | 0.193 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.641114 | 0.193 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.644177 | 0.191 |
| R-HSA-202403 | TCR signaling | 0.647215 | 0.189 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.647215 | 0.189 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.647215 | 0.189 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.653212 | 0.185 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.656173 | 0.183 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.656173 | 0.183 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.664905 | 0.177 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.664905 | 0.177 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.667766 | 0.175 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.670604 | 0.174 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.670604 | 0.174 |
| R-HSA-373760 | L1CAM interactions | 0.670604 | 0.174 |
| R-HSA-9609646 | HCMV Infection | 0.671005 | 0.173 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.673417 | 0.172 |
| R-HSA-70326 | Glucose metabolism | 0.673417 | 0.172 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.678972 | 0.168 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.678972 | 0.168 |
| R-HSA-73886 | Chromosome Maintenance | 0.684433 | 0.165 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.687129 | 0.163 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.687129 | 0.163 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.689802 | 0.161 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.692453 | 0.160 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.692453 | 0.160 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.697686 | 0.156 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.697686 | 0.156 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.697686 | 0.156 |
| R-HSA-69206 | G1/S Transition | 0.697686 | 0.156 |
| R-HSA-194138 | Signaling by VEGF | 0.697686 | 0.156 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.710387 | 0.149 |
| R-HSA-1266738 | Developmental Biology | 0.713247 | 0.147 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.717751 | 0.144 |
| R-HSA-9909396 | Circadian clock | 0.717751 | 0.144 |
| R-HSA-168249 | Innate Immune System | 0.720533 | 0.142 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.722747 | 0.141 |
| R-HSA-9658195 | Leishmania infection | 0.727867 | 0.138 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.727867 | 0.138 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.729614 | 0.137 |
| R-HSA-1483257 | Phospholipid metabolism | 0.750719 | 0.125 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.753999 | 0.123 |
| R-HSA-195721 | Signaling by WNT | 0.755397 | 0.122 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.758192 | 0.120 |
| R-HSA-9758941 | Gastrulation | 0.760262 | 0.119 |
| R-HSA-168256 | Immune System | 0.765654 | 0.116 |
| R-HSA-9609507 | Protein localization | 0.768367 | 0.114 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.772317 | 0.112 |
| R-HSA-9610379 | HCMV Late Events | 0.776200 | 0.110 |
| R-HSA-9711097 | Cellular response to starvation | 0.778117 | 0.109 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.781901 | 0.107 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.785445 | 0.105 |
| R-HSA-112316 | Neuronal System | 0.788936 | 0.103 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.791534 | 0.102 |
| R-HSA-5619102 | SLC transporter disorders | 0.794650 | 0.100 |
| R-HSA-1280218 | Adaptive Immune System | 0.809522 | 0.092 |
| R-HSA-168255 | Influenza Infection | 0.816396 | 0.088 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.822615 | 0.085 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.824077 | 0.084 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.834432 | 0.079 |
| R-HSA-211859 | Biological oxidations | 0.845031 | 0.073 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.850709 | 0.070 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.850709 | 0.070 |
| R-HSA-6805567 | Keratinization | 0.855773 | 0.068 |
| R-HSA-597592 | Post-translational protein modification | 0.857111 | 0.067 |
| R-HSA-397014 | Muscle contraction | 0.863051 | 0.064 |
| R-HSA-9748784 | Drug ADME | 0.869965 | 0.060 |
| R-HSA-8951664 | Neddylation | 0.873291 | 0.059 |
| R-HSA-15869 | Metabolism of nucleotides | 0.888695 | 0.051 |
| R-HSA-8939211 | ESR-mediated signaling | 0.889653 | 0.051 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.891544 | 0.050 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.898795 | 0.046 |
| R-HSA-5688426 | Deubiquitination | 0.905564 | 0.043 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.910013 | 0.041 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.915618 | 0.038 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.923290 | 0.035 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.925260 | 0.034 |
| R-HSA-8953854 | Metabolism of RNA | 0.936879 | 0.028 |
| R-HSA-1474244 | Extracellular matrix organization | 0.951162 | 0.022 |
| R-HSA-9679506 | SARS-CoV Infections | 0.958616 | 0.018 |
| R-HSA-392499 | Metabolism of proteins | 0.962352 | 0.017 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.963037 | 0.016 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.969223 | 0.014 |
| R-HSA-109582 | Hemostasis | 0.969782 | 0.013 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.971047 | 0.013 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.972041 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 0.975042 | 0.011 |
| R-HSA-449147 | Signaling by Interleukins | 0.975359 | 0.011 |
| R-HSA-72766 | Translation | 0.979411 | 0.009 |
| R-HSA-1643685 | Disease | 0.979821 | 0.009 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.983604 | 0.007 |
| R-HSA-9824446 | Viral Infection Pathways | 0.989818 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 0.992114 | 0.003 |
| R-HSA-5663205 | Infectious disease | 0.992640 | 0.003 |
| R-HSA-500792 | GPCR ligand binding | 0.994961 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.995893 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996102 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.998481 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999840 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.798 | 0.264 | 1 | 0.829 |
CLK3 |
0.793 | 0.195 | 1 | 0.822 |
HIPK2 |
0.790 | 0.260 | 1 | 0.761 |
SRPK1 |
0.788 | 0.202 | -3 | 0.818 |
DYRK2 |
0.785 | 0.242 | 1 | 0.813 |
CDKL5 |
0.783 | 0.184 | -3 | 0.834 |
HIPK1 |
0.783 | 0.259 | 1 | 0.818 |
CDC7 |
0.780 | 0.100 | 1 | 0.755 |
SRPK2 |
0.779 | 0.175 | -3 | 0.758 |
CDKL1 |
0.778 | 0.158 | -3 | 0.837 |
NLK |
0.778 | 0.180 | 1 | 0.839 |
PRKD2 |
0.778 | 0.138 | -3 | 0.813 |
NUAK2 |
0.778 | 0.164 | -3 | 0.863 |
PIM3 |
0.777 | 0.100 | -3 | 0.855 |
PRKD1 |
0.776 | 0.134 | -3 | 0.837 |
CDK7 |
0.776 | 0.172 | 1 | 0.777 |
ICK |
0.776 | 0.188 | -3 | 0.859 |
CDK19 |
0.775 | 0.189 | 1 | 0.747 |
CLK1 |
0.775 | 0.188 | -3 | 0.806 |
CLK2 |
0.775 | 0.202 | -3 | 0.815 |
RSK2 |
0.774 | 0.127 | -3 | 0.825 |
HIPK3 |
0.774 | 0.258 | 1 | 0.799 |
CDK8 |
0.773 | 0.174 | 1 | 0.768 |
MAPKAPK3 |
0.773 | 0.119 | -3 | 0.810 |
AMPKA2 |
0.772 | 0.171 | -3 | 0.837 |
WNK1 |
0.772 | 0.123 | -2 | 0.831 |
AMPKA1 |
0.772 | 0.154 | -3 | 0.853 |
DYRK1A |
0.771 | 0.231 | 1 | 0.808 |
SRPK3 |
0.771 | 0.168 | -3 | 0.788 |
CDK18 |
0.771 | 0.195 | 1 | 0.728 |
KIS |
0.771 | 0.158 | 1 | 0.785 |
PIM1 |
0.771 | 0.121 | -3 | 0.834 |
MTOR |
0.771 | 0.016 | 1 | 0.733 |
CLK4 |
0.771 | 0.164 | -3 | 0.825 |
CAMK1B |
0.770 | 0.102 | -3 | 0.861 |
P90RSK |
0.770 | 0.116 | -3 | 0.822 |
ERK5 |
0.769 | 0.109 | 1 | 0.767 |
COT |
0.769 | -0.044 | 2 | 0.808 |
MARK4 |
0.769 | 0.129 | 4 | 0.836 |
CDK13 |
0.769 | 0.177 | 1 | 0.760 |
DYRK4 |
0.769 | 0.215 | 1 | 0.766 |
DYRK3 |
0.769 | 0.218 | 1 | 0.820 |
TSSK1 |
0.768 | 0.148 | -3 | 0.862 |
MAPKAPK2 |
0.768 | 0.101 | -3 | 0.787 |
RSK3 |
0.767 | 0.117 | -3 | 0.811 |
MOS |
0.767 | 0.026 | 1 | 0.784 |
PRPK |
0.767 | 0.007 | -1 | 0.302 |
NDR2 |
0.767 | 0.017 | -3 | 0.838 |
CDK5 |
0.767 | 0.190 | 1 | 0.779 |
QSK |
0.767 | 0.148 | 4 | 0.826 |
JNK2 |
0.767 | 0.207 | 1 | 0.749 |
DYRK1B |
0.766 | 0.214 | 1 | 0.766 |
MOK |
0.766 | 0.261 | 1 | 0.797 |
CDK10 |
0.766 | 0.205 | 1 | 0.748 |
SIK |
0.765 | 0.140 | -3 | 0.796 |
CDK9 |
0.765 | 0.179 | 1 | 0.765 |
CDK12 |
0.764 | 0.177 | 1 | 0.744 |
PRKD3 |
0.764 | 0.132 | -3 | 0.802 |
AURC |
0.764 | 0.071 | -2 | 0.595 |
RAF1 |
0.764 | 0.007 | 1 | 0.737 |
P70S6KB |
0.764 | 0.099 | -3 | 0.827 |
CHAK2 |
0.764 | 0.027 | -1 | 0.267 |
ATR |
0.764 | 0.063 | 1 | 0.722 |
MAK |
0.764 | 0.240 | -2 | 0.754 |
NDR1 |
0.763 | 0.044 | -3 | 0.841 |
P38A |
0.761 | 0.196 | 1 | 0.776 |
NIK |
0.761 | 0.089 | -3 | 0.848 |
P38B |
0.761 | 0.203 | 1 | 0.739 |
MST4 |
0.761 | 0.026 | 2 | 0.826 |
P38G |
0.761 | 0.194 | 1 | 0.694 |
ERK1 |
0.761 | 0.181 | 1 | 0.736 |
PKN2 |
0.761 | 0.064 | -3 | 0.845 |
SKMLCK |
0.761 | 0.054 | -2 | 0.800 |
TSSK2 |
0.761 | 0.117 | -5 | 0.842 |
CAMLCK |
0.761 | 0.077 | -2 | 0.774 |
PKACG |
0.760 | 0.058 | -2 | 0.672 |
NUAK1 |
0.760 | 0.114 | -3 | 0.814 |
JNK3 |
0.760 | 0.184 | 1 | 0.763 |
CDK1 |
0.760 | 0.157 | 1 | 0.753 |
TBK1 |
0.759 | -0.005 | 1 | 0.637 |
PDHK4 |
0.759 | -0.078 | 1 | 0.761 |
PKCD |
0.759 | 0.065 | 2 | 0.746 |
PKN3 |
0.759 | 0.043 | -3 | 0.831 |
CAMK2D |
0.759 | 0.046 | -3 | 0.834 |
IKKB |
0.758 | -0.073 | -2 | 0.681 |
PDHK1 |
0.758 | -0.004 | 1 | 0.750 |
RSK4 |
0.758 | 0.105 | -3 | 0.801 |
AKT2 |
0.758 | 0.129 | -3 | 0.774 |
DAPK2 |
0.758 | 0.069 | -3 | 0.858 |
CDK17 |
0.757 | 0.168 | 1 | 0.694 |
MNK2 |
0.757 | 0.066 | -2 | 0.736 |
QIK |
0.757 | 0.074 | -3 | 0.830 |
PKACB |
0.757 | 0.091 | -2 | 0.607 |
MARK3 |
0.757 | 0.129 | 4 | 0.801 |
PKCB |
0.757 | 0.084 | 2 | 0.708 |
PAK6 |
0.757 | 0.084 | -2 | 0.657 |
CDK14 |
0.757 | 0.180 | 1 | 0.756 |
PIM2 |
0.756 | 0.133 | -3 | 0.803 |
MELK |
0.756 | 0.077 | -3 | 0.823 |
P38D |
0.756 | 0.203 | 1 | 0.708 |
NIM1 |
0.755 | 0.044 | 3 | 0.772 |
NEK6 |
0.755 | -0.008 | -2 | 0.741 |
LATS2 |
0.755 | 0.002 | -5 | 0.712 |
BCKDK |
0.755 | -0.075 | -1 | 0.260 |
BMPR2 |
0.755 | -0.146 | -2 | 0.774 |
IRE1 |
0.755 | 0.062 | 1 | 0.685 |
PRKX |
0.755 | 0.090 | -3 | 0.760 |
SGK3 |
0.754 | 0.112 | -3 | 0.811 |
IKKE |
0.754 | -0.045 | 1 | 0.638 |
PHKG1 |
0.753 | 0.055 | -3 | 0.838 |
HUNK |
0.753 | 0.035 | 2 | 0.762 |
PKCA |
0.753 | 0.063 | 2 | 0.704 |
ULK2 |
0.753 | -0.071 | 2 | 0.742 |
BRSK1 |
0.753 | 0.087 | -3 | 0.818 |
PKCZ |
0.753 | 0.068 | 2 | 0.759 |
DSTYK |
0.752 | -0.050 | 2 | 0.843 |
CDK16 |
0.752 | 0.181 | 1 | 0.705 |
GCN2 |
0.752 | -0.151 | 2 | 0.772 |
WNK3 |
0.752 | -0.078 | 1 | 0.698 |
PKCG |
0.752 | 0.048 | 2 | 0.704 |
MSK2 |
0.752 | 0.055 | -3 | 0.804 |
PAK3 |
0.751 | 0.039 | -2 | 0.728 |
BRSK2 |
0.751 | 0.077 | -3 | 0.822 |
MARK2 |
0.751 | 0.110 | 4 | 0.773 |
CDK3 |
0.751 | 0.154 | 1 | 0.708 |
PKG2 |
0.751 | 0.060 | -2 | 0.608 |
PAK1 |
0.751 | 0.041 | -2 | 0.732 |
MLK1 |
0.750 | -0.065 | 2 | 0.771 |
CAMK2A |
0.750 | 0.034 | 2 | 0.751 |
GRK1 |
0.750 | -0.034 | -2 | 0.721 |
NEK9 |
0.749 | -0.014 | 2 | 0.811 |
GRK5 |
0.749 | -0.112 | -3 | 0.802 |
CAMK2G |
0.749 | -0.097 | 2 | 0.760 |
MNK1 |
0.749 | 0.045 | -2 | 0.741 |
ERK2 |
0.749 | 0.139 | 1 | 0.766 |
AURB |
0.748 | 0.043 | -2 | 0.595 |
NEK7 |
0.748 | -0.074 | -3 | 0.777 |
RIPK3 |
0.748 | -0.081 | 3 | 0.677 |
MSK1 |
0.748 | 0.066 | -3 | 0.802 |
MYLK4 |
0.747 | 0.061 | -2 | 0.700 |
TGFBR2 |
0.747 | -0.082 | -2 | 0.639 |
AKT1 |
0.747 | 0.107 | -3 | 0.785 |
CDK4 |
0.747 | 0.182 | 1 | 0.739 |
CAMK4 |
0.746 | -0.011 | -3 | 0.829 |
PKCH |
0.746 | 0.054 | 2 | 0.688 |
MLK2 |
0.746 | -0.043 | 2 | 0.786 |
CAMK2B |
0.745 | 0.003 | 2 | 0.727 |
PKACA |
0.745 | 0.091 | -2 | 0.557 |
MARK1 |
0.745 | 0.088 | 4 | 0.802 |
PKR |
0.745 | 0.015 | 1 | 0.739 |
PRP4 |
0.745 | 0.095 | -3 | 0.695 |
MAPKAPK5 |
0.745 | 0.046 | -3 | 0.773 |
RIPK1 |
0.745 | -0.101 | 1 | 0.696 |
CAMK1G |
0.744 | 0.072 | -3 | 0.807 |
SSTK |
0.744 | 0.096 | 4 | 0.797 |
NEK2 |
0.744 | 0.045 | 2 | 0.805 |
CHAK1 |
0.744 | -0.003 | 2 | 0.782 |
WNK4 |
0.744 | 0.075 | -2 | 0.826 |
P70S6K |
0.743 | 0.096 | -3 | 0.768 |
DCAMKL1 |
0.743 | 0.072 | -3 | 0.823 |
BMPR1B |
0.743 | 0.010 | 1 | 0.704 |
GRK6 |
0.743 | -0.074 | 1 | 0.725 |
MPSK1 |
0.742 | 0.080 | 1 | 0.677 |
CDK2 |
0.742 | 0.090 | 1 | 0.783 |
DLK |
0.742 | -0.119 | 1 | 0.716 |
LATS1 |
0.742 | -0.015 | -3 | 0.840 |
PKCT |
0.741 | 0.070 | 2 | 0.695 |
IKKA |
0.741 | -0.088 | -2 | 0.677 |
CHK1 |
0.741 | 0.038 | -3 | 0.800 |
PKCI |
0.741 | 0.078 | 2 | 0.724 |
MLK3 |
0.741 | -0.039 | 2 | 0.711 |
TTBK2 |
0.741 | -0.074 | 2 | 0.689 |
CDK6 |
0.740 | 0.161 | 1 | 0.739 |
ATM |
0.740 | -0.059 | 1 | 0.662 |
DNAPK |
0.740 | 0.021 | 1 | 0.624 |
IRE2 |
0.740 | 0.010 | 2 | 0.695 |
PAK2 |
0.740 | 0.008 | -2 | 0.714 |
MASTL |
0.740 | -0.150 | -2 | 0.752 |
ULK1 |
0.739 | -0.103 | -3 | 0.731 |
VRK2 |
0.739 | -0.015 | 1 | 0.784 |
FAM20C |
0.739 | -0.004 | 2 | 0.554 |
SMG1 |
0.739 | -0.043 | 1 | 0.679 |
PKCE |
0.738 | 0.090 | 2 | 0.698 |
CAMK1D |
0.738 | 0.092 | -3 | 0.753 |
CK1E |
0.738 | 0.038 | -3 | 0.612 |
AKT3 |
0.738 | 0.116 | -3 | 0.733 |
ERK7 |
0.738 | 0.100 | 2 | 0.576 |
PHKG2 |
0.737 | 0.059 | -3 | 0.819 |
AURA |
0.737 | 0.018 | -2 | 0.572 |
SBK |
0.737 | 0.140 | -3 | 0.685 |
BUB1 |
0.737 | 0.129 | -5 | 0.858 |
MST3 |
0.736 | 0.054 | 2 | 0.819 |
CHK2 |
0.736 | 0.114 | -3 | 0.735 |
MEK1 |
0.736 | -0.054 | 2 | 0.792 |
ANKRD3 |
0.736 | -0.138 | 1 | 0.728 |
PAK5 |
0.736 | 0.045 | -2 | 0.599 |
GRK4 |
0.735 | -0.138 | -2 | 0.721 |
SGK1 |
0.735 | 0.117 | -3 | 0.715 |
SNRK |
0.734 | -0.038 | 2 | 0.636 |
GRK7 |
0.734 | -0.029 | 1 | 0.659 |
JNK1 |
0.733 | 0.140 | 1 | 0.735 |
PKN1 |
0.733 | 0.090 | -3 | 0.789 |
MLK4 |
0.733 | -0.061 | 2 | 0.682 |
ALK4 |
0.733 | -0.074 | -2 | 0.695 |
CAMK1A |
0.732 | 0.109 | -3 | 0.737 |
IRAK4 |
0.732 | -0.015 | 1 | 0.685 |
PAK4 |
0.732 | 0.040 | -2 | 0.606 |
YSK4 |
0.732 | -0.080 | 1 | 0.665 |
SMMLCK |
0.732 | 0.043 | -3 | 0.837 |
CK1G1 |
0.731 | 0.043 | -3 | 0.592 |
CK1D |
0.731 | 0.041 | -3 | 0.569 |
LKB1 |
0.730 | 0.106 | -3 | 0.766 |
TGFBR1 |
0.729 | -0.071 | -2 | 0.663 |
MRCKB |
0.729 | 0.094 | -3 | 0.788 |
PINK1 |
0.729 | -0.020 | 1 | 0.767 |
TLK2 |
0.728 | -0.056 | 1 | 0.680 |
TAO3 |
0.728 | -0.013 | 1 | 0.690 |
ROCK2 |
0.728 | 0.097 | -3 | 0.823 |
MEK5 |
0.727 | -0.071 | 2 | 0.781 |
DAPK3 |
0.727 | 0.062 | -3 | 0.837 |
PERK |
0.727 | -0.087 | -2 | 0.699 |
NEK5 |
0.726 | -0.013 | 1 | 0.695 |
DCAMKL2 |
0.726 | 0.004 | -3 | 0.833 |
BRAF |
0.726 | -0.044 | -4 | 0.815 |
ACVR2A |
0.726 | -0.085 | -2 | 0.626 |
CK1A2 |
0.726 | 0.032 | -3 | 0.577 |
ACVR2B |
0.726 | -0.084 | -2 | 0.645 |
PLK1 |
0.724 | -0.144 | -2 | 0.679 |
PASK |
0.724 | -0.023 | -3 | 0.862 |
ALK2 |
0.724 | -0.083 | -2 | 0.669 |
HPK1 |
0.724 | 0.066 | 1 | 0.699 |
NEK4 |
0.724 | 0.073 | 1 | 0.687 |
GSK3A |
0.724 | 0.026 | 4 | 0.422 |
GRK2 |
0.724 | -0.064 | -2 | 0.615 |
MEKK6 |
0.723 | 0.070 | 1 | 0.673 |
MEKK1 |
0.723 | -0.101 | 1 | 0.694 |
CAMKK2 |
0.723 | 0.039 | -2 | 0.720 |
HRI |
0.722 | -0.125 | -2 | 0.706 |
DRAK1 |
0.722 | -0.089 | 1 | 0.627 |
TNIK |
0.722 | 0.070 | 3 | 0.861 |
ZAK |
0.722 | -0.096 | 1 | 0.666 |
GSK3B |
0.722 | -0.003 | 4 | 0.417 |
HGK |
0.722 | 0.060 | 3 | 0.855 |
MEKK2 |
0.722 | -0.050 | 2 | 0.761 |
TAO2 |
0.722 | -0.009 | 2 | 0.814 |
MRCKA |
0.722 | 0.065 | -3 | 0.797 |
KHS2 |
0.721 | 0.091 | 1 | 0.709 |
LRRK2 |
0.721 | 0.020 | 2 | 0.822 |
TLK1 |
0.721 | -0.074 | -2 | 0.689 |
KHS1 |
0.720 | 0.079 | 1 | 0.695 |
CRIK |
0.720 | 0.129 | -3 | 0.783 |
CAMKK1 |
0.720 | -0.029 | -2 | 0.720 |
DMPK1 |
0.720 | 0.113 | -3 | 0.815 |
GCK |
0.720 | 0.017 | 1 | 0.703 |
GAK |
0.719 | -0.016 | 1 | 0.716 |
HASPIN |
0.719 | 0.008 | -1 | 0.222 |
PDK1 |
0.719 | -0.013 | 1 | 0.676 |
DAPK1 |
0.719 | 0.046 | -3 | 0.831 |
MEKK3 |
0.718 | -0.129 | 1 | 0.692 |
BMPR1A |
0.718 | -0.050 | 1 | 0.689 |
PKG1 |
0.718 | 0.051 | -2 | 0.530 |
NEK1 |
0.718 | 0.070 | 1 | 0.680 |
LOK |
0.718 | 0.017 | -2 | 0.700 |
NEK11 |
0.718 | -0.061 | 1 | 0.677 |
PLK3 |
0.717 | -0.131 | 2 | 0.717 |
ROCK1 |
0.717 | 0.094 | -3 | 0.798 |
MINK |
0.716 | 0.024 | 1 | 0.690 |
NEK8 |
0.716 | -0.069 | 2 | 0.784 |
PLK4 |
0.716 | -0.107 | 2 | 0.573 |
PBK |
0.716 | 0.040 | 1 | 0.633 |
IRAK1 |
0.715 | -0.139 | -1 | 0.233 |
EEF2K |
0.715 | 0.033 | 3 | 0.821 |
MAP3K15 |
0.715 | -0.009 | 1 | 0.649 |
TTBK1 |
0.713 | -0.108 | 2 | 0.600 |
VRK1 |
0.712 | -0.044 | 2 | 0.773 |
GRK3 |
0.710 | -0.061 | -2 | 0.571 |
YSK1 |
0.710 | 0.015 | 2 | 0.793 |
CK2A2 |
0.710 | -0.036 | 1 | 0.644 |
TAK1 |
0.710 | -0.072 | 1 | 0.699 |
PDHK3_TYR |
0.709 | 0.085 | 4 | 0.830 |
SLK |
0.709 | -0.047 | -2 | 0.644 |
LIMK2_TYR |
0.708 | 0.133 | -3 | 0.831 |
STK33 |
0.706 | -0.071 | 2 | 0.585 |
NEK3 |
0.706 | -0.002 | 1 | 0.646 |
MST2 |
0.705 | -0.093 | 1 | 0.701 |
MYO3B |
0.704 | 0.054 | 2 | 0.810 |
TESK1_TYR |
0.703 | 0.035 | 3 | 0.862 |
MAP2K4_TYR |
0.701 | -0.005 | -1 | 0.288 |
PKMYT1_TYR |
0.700 | 0.030 | 3 | 0.805 |
CK2A1 |
0.699 | -0.040 | 1 | 0.626 |
MEK2 |
0.698 | -0.110 | 2 | 0.769 |
MST1 |
0.698 | -0.095 | 1 | 0.685 |
PDHK4_TYR |
0.698 | -0.042 | 2 | 0.828 |
TAO1 |
0.696 | -0.017 | 1 | 0.624 |
MAP2K6_TYR |
0.696 | -0.046 | -1 | 0.289 |
TNNI3K_TYR |
0.695 | 0.168 | 1 | 0.723 |
MAP2K7_TYR |
0.695 | -0.067 | 2 | 0.812 |
CK1A |
0.695 | 0.019 | -3 | 0.489 |
RIPK2 |
0.695 | -0.165 | 1 | 0.622 |
OSR1 |
0.694 | -0.057 | 2 | 0.768 |
LIMK1_TYR |
0.694 | -0.003 | 2 | 0.813 |
BIKE |
0.694 | -0.014 | 1 | 0.605 |
PINK1_TYR |
0.692 | -0.076 | 1 | 0.729 |
BMPR2_TYR |
0.691 | -0.096 | -1 | 0.270 |
MYO3A |
0.691 | -0.013 | 1 | 0.702 |
PDHK1_TYR |
0.689 | -0.124 | -1 | 0.270 |
RET |
0.689 | -0.052 | 1 | 0.692 |
PLK2 |
0.689 | -0.105 | -3 | 0.680 |
ASK1 |
0.689 | -0.074 | 1 | 0.640 |
TTK |
0.687 | -0.074 | -2 | 0.682 |
YANK3 |
0.685 | -0.041 | 2 | 0.382 |
TYK2 |
0.685 | -0.038 | 1 | 0.682 |
ABL2 |
0.685 | -0.054 | -1 | 0.246 |
ROS1 |
0.684 | -0.036 | 3 | 0.749 |
EPHA6 |
0.684 | -0.084 | -1 | 0.268 |
TYRO3 |
0.684 | -0.081 | 3 | 0.772 |
ALPHAK3 |
0.683 | -0.087 | -1 | 0.246 |
EPHB4 |
0.683 | -0.117 | -1 | 0.245 |
TXK |
0.683 | -0.064 | 1 | 0.721 |
NEK10_TYR |
0.683 | 0.001 | 1 | 0.580 |
AAK1 |
0.682 | 0.008 | 1 | 0.518 |
MST1R |
0.682 | -0.108 | 3 | 0.756 |
ABL1 |
0.682 | -0.058 | -1 | 0.246 |
JAK2 |
0.682 | -0.050 | 1 | 0.686 |
JAK1 |
0.681 | 0.038 | 1 | 0.632 |
DDR1 |
0.680 | -0.062 | 4 | 0.763 |
TNK1 |
0.679 | -0.025 | 3 | 0.750 |
TNK2 |
0.678 | -0.066 | 3 | 0.687 |
WEE1_TYR |
0.678 | -0.050 | -1 | 0.229 |
FGR |
0.678 | -0.088 | 1 | 0.707 |
JAK3 |
0.677 | -0.113 | 1 | 0.660 |
CSF1R |
0.677 | -0.096 | 3 | 0.731 |
ITK |
0.677 | -0.105 | -1 | 0.231 |
LCK |
0.675 | -0.081 | -1 | 0.254 |
FER |
0.675 | -0.128 | 1 | 0.743 |
BMX |
0.675 | -0.098 | -1 | 0.199 |
YES1 |
0.672 | -0.140 | -1 | 0.250 |
BLK |
0.671 | -0.082 | -1 | 0.245 |
HCK |
0.671 | -0.146 | -1 | 0.247 |
EPHB1 |
0.671 | -0.144 | 1 | 0.715 |
STLK3 |
0.671 | -0.133 | 1 | 0.641 |
SRMS |
0.670 | -0.147 | 1 | 0.725 |
INSRR |
0.670 | -0.125 | 3 | 0.700 |
PDGFRB |
0.669 | -0.134 | 3 | 0.757 |
CK1G3 |
0.669 | 0.002 | -3 | 0.447 |
AXL |
0.669 | -0.122 | 3 | 0.718 |
EPHB3 |
0.669 | -0.151 | -1 | 0.243 |
PTK6 |
0.669 | -0.150 | -1 | 0.229 |
TEC |
0.669 | -0.135 | -1 | 0.202 |
MERTK |
0.669 | -0.119 | 3 | 0.715 |
EPHA4 |
0.667 | -0.125 | 2 | 0.719 |
EPHB2 |
0.667 | -0.159 | -1 | 0.233 |
KIT |
0.667 | -0.144 | 3 | 0.724 |
KDR |
0.667 | -0.114 | 3 | 0.680 |
BTK |
0.666 | -0.184 | -1 | 0.213 |
FLT3 |
0.666 | -0.135 | 3 | 0.755 |
FGFR2 |
0.666 | -0.153 | 3 | 0.724 |
MET |
0.666 | -0.126 | 3 | 0.726 |
TEK |
0.665 | -0.140 | 3 | 0.685 |
ALK |
0.665 | -0.100 | 3 | 0.661 |
DDR2 |
0.664 | -0.009 | 3 | 0.658 |
FGFR1 |
0.664 | -0.131 | 3 | 0.706 |
PDGFRA |
0.662 | -0.157 | 3 | 0.753 |
LTK |
0.661 | -0.121 | 3 | 0.665 |
EPHA1 |
0.661 | -0.132 | 3 | 0.701 |
PTK2B |
0.659 | -0.098 | -1 | 0.252 |
FYN |
0.659 | -0.130 | -1 | 0.238 |
MATK |
0.658 | -0.127 | -1 | 0.212 |
EPHA7 |
0.657 | -0.156 | 2 | 0.723 |
INSR |
0.656 | -0.123 | 3 | 0.683 |
FRK |
0.655 | -0.156 | -1 | 0.243 |
EPHA3 |
0.655 | -0.176 | 2 | 0.692 |
FLT1 |
0.654 | -0.190 | -1 | 0.235 |
ERBB2 |
0.654 | -0.171 | 1 | 0.642 |
FGFR3 |
0.653 | -0.173 | 3 | 0.687 |
LYN |
0.652 | -0.168 | 3 | 0.643 |
NTRK1 |
0.652 | -0.221 | -1 | 0.246 |
YANK2 |
0.651 | -0.055 | 2 | 0.392 |
NTRK2 |
0.650 | -0.210 | 3 | 0.680 |
NTRK3 |
0.650 | -0.169 | -1 | 0.241 |
CSK |
0.650 | -0.141 | 2 | 0.724 |
PTK2 |
0.650 | -0.106 | -1 | 0.228 |
SYK |
0.649 | -0.112 | -1 | 0.226 |
FLT4 |
0.648 | -0.200 | 3 | 0.666 |
EPHA5 |
0.647 | -0.178 | 2 | 0.695 |
SRC |
0.647 | -0.162 | -1 | 0.236 |
EPHA8 |
0.646 | -0.173 | -1 | 0.221 |
EGFR |
0.645 | -0.140 | 1 | 0.553 |
MUSK |
0.642 | -0.142 | 1 | 0.524 |
CK1G2 |
0.642 | -0.036 | -3 | 0.523 |
FGFR4 |
0.640 | -0.162 | -1 | 0.226 |
IGF1R |
0.638 | -0.147 | 3 | 0.613 |
ZAP70 |
0.636 | -0.082 | -1 | 0.216 |
EPHA2 |
0.635 | -0.187 | -1 | 0.205 |
ERBB4 |
0.634 | -0.127 | 1 | 0.584 |
FES |
0.630 | -0.164 | -1 | 0.200 |