Motif 213 (n=182)

Position-wise Probabilities
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uniprot genes site source protein function
B7Z1M9 C2CD4D S128 ochoa C2 calcium-dependent domain-containing protein 4D None
O00291 HIP1 S338 ochoa Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}.
O00506 STK25 S231 ochoa Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}.
O43166 SIPA1L1 S255 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43293 DAPK3 S309 ochoa Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}.
O43683 BUB1 S679 psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O43847 NRDC S61 ochoa Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}.
O60318 MCM3AP S556 ochoa Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:20384790, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269|PubMed:11258703, ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:23652018}.
O60343 TBC1D4 S644 ochoa TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. {ECO:0000269|PubMed:15971998, ECO:0000269|PubMed:18771725, ECO:0000269|PubMed:22908308}.
O60741 HCN1 S770 psp Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (By similarity). {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}.
O75128 COBL S974 ochoa Protein cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
O75140 DEPDC5 S502 ochoa GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:31548394, PubMed:35338845). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:25457612, PubMed:29590090, PubMed:29769719, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway (PubMed:23723238, PubMed:25457612, PubMed:29769719). Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state (PubMed:29590090, PubMed:35338845). However, it does not execute the GAP activity, which is mediated by NPRL2 (PubMed:29590090). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29590090, ECO:0000269|PubMed:29769719, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:35338845}.
O75369 FLNB S1523 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75385 ULK1 S556 ochoa|psp Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75420 GIGYF1 S862 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75478 TADA2A S361 ochoa Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.
O75762 TRPA1 S43 ochoa Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}.
O94887 FARP2 S457 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O94913 PCF11 S1179 ochoa Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}.
O95865 DDAH2 S245 psp Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}.
O95997 PTTG1 S31 psp Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}.
P01009 SERPINA1 S260 ochoa Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; FUNCTION: [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
P03372 ESR1 S341 psp Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.
P04150 NR3C1 S44 ochoa Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.
P05177 CYP1A2 S82 ochoa Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}.
P08151 GLI1 S1078 psp Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P08833 IGFBP1 S83 psp Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}.
P16144 ITGB4 S1454 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P19367 HK1 S89 ochoa Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) (Hexokinase-A) Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.
P21333 FLNA S1454 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S1551 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S2053 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21730 C5AR1 S314 psp C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
P30530 AXL S851 ochoa Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}.
P31152 MAPK4 S386 ochoa Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
P33981 TTK S455 ochoa Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35916 FLT4 S1217 ochoa Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.
P38398 BRCA1 S1596 ochoa Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P41162 ETV3 S170 ochoa ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.
P46108 CRK S96 ochoa Adapter molecule crk (Proto-oncogene c-Crk) (p38) Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}.
P48552 NRIP1 S626 ochoa Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140) Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). {ECO:0000250|UniProtKB:Q8CBD1, ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:7641693}.
P54132 BLM S449 ochoa RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}.
P54762 EPHB1 S899 ochoa Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}.
P55198 MLLT6 S563 ochoa Protein AF-17 (ALL1-fused gene from chromosome 17 protein) None
P56524 HDAC4 S265 ochoa|psp Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P78314 SH3BP2 S278 ochoa|psp SH3 domain-binding protein 2 (3BP-2) Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
P78345 RPP38 S215 ochoa Ribonuclease P protein subunit p38 (RNaseP protein p38) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:10444065, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:9037013, ECO:0000269|PubMed:9630247}.
P78559 MAP1A S579 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q00872 MYBPC1 S825 ochoa Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}.
Q04721 NOTCH2 S2115 ochoa Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.
Q08188 TGM3 S124 ochoa Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain] Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. {ECO:0000250}.
Q12802 AKAP13 S1226 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12888 TP53BP1 S280 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12888 TP53BP1 S1480 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13131 PRKAA1 S467 psp 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.
Q13191 CBLB S634 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13423 NNT S769 ochoa NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase) The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753). {ECO:0000250|UniProtKB:P07001, ECO:0000269|PubMed:22634753}.
Q13470 TNK1 S582 ochoa Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q13625 TP53BP2 S361 ochoa|psp Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}.
Q13950 RUNX2 S347 psp Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.
Q14315 FLNC S480 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1161 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1449 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14315 FLNC S1545 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q15759 MAPK11 S261 psp Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}.
Q16473 TNXA S142 ochoa Putative tenascin-XA (TN-XA) None
Q16643 DBN1 S141 ochoa|psp Drebrin (Developmentally-regulated brain protein) Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.
Q2LD37 BLTP1 S2300 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q3MIX3 ADCK5 S42 ochoa Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
Q53GS7 GLE1 S41 ochoa mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). {ECO:0000269|PubMed:12668658, ECO:0000269|PubMed:16000379, ECO:0000269|PubMed:9618489}.
Q5JSZ5 PRRC2B S1826 ochoa Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) None
Q5JXC2 MIIP S113 ochoa Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45) Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}.
Q5T0W9 FAM83B S598 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q5TCZ1 SH3PXD2A S379 ochoa SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
Q5UIP0 RIF1 S1525 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q5VT52 RPRD2 S908 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q5W0B1 OBI1 S75 ochoa ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}.
Q641Q2 WASHC2A S1001 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q69YZ2 TMEM200B S282 ochoa Transmembrane protein 200B (Transmembrane protein TTMA) (Two transmembrane domain-containing family member B) None
Q6FI81 CIAPIN1 S287 ochoa Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.
Q6IQ23 PLEKHA7 S643 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6NYC8 PPP1R18 S163 ochoa Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}.
Q6W2J9 BCOR S422 ochoa BCL-6 corepressor (BCoR) Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.
Q6ZW31 SYDE1 S576 ochoa Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.
Q7L591 DOK3 S364 ochoa Docking protein 3 (Downstream of tyrosine kinase 3) DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
Q7L9B9 EEPD1 S149 ochoa Endonuclease/exonuclease/phosphatase family domain-containing protein 1 None
Q7Z3B3 KANSL1 S1021 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z402 TMC7 S86 ochoa Transmembrane channel-like protein 7 Acts as an inhibitory modulator of PIEZO2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton. {ECO:0000250|UniProtKB:Q8C428}.
Q7Z5R6 APBB1IP S55 ochoa Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Q86VY9 TMEM200A S384 ochoa Transmembrane protein 200A None
Q86XN8 MEX3D S592 ochoa RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}.
Q86YD1 PTOV1 S72 ochoa Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}.
Q8IVE3 PLEKHH2 S1458 ochoa Pleckstrin homology domain-containing family H member 2 In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
Q8IVL1 NAV2 S1502 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IYM2 SLFN12 S368 psp Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12) Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269|PubMed:30045019, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34272366, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:35104454}.
Q8IYT8 ULK2 S528 ochoa Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}.
Q8N1I0 DOCK4 S1750 ochoa Dedicator of cytokinesis protein 4 Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}.
Q8N612 FHIP1B S901 ochoa FHF complex subunit HOOK-interacting protein 1B (FHIP1B) (FTS- and Hook-interacting protein) (FHIP) Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}.
Q8NAA4 ATG16L2 S278 ochoa Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. {ECO:0000250|UniProtKB:Q6KAU8}.
Q8ND82 ZNF280C S515 ochoa Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) May function as a transcription factor.
Q8NHQ8 RASSF8 S105 ochoa Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) None
Q8TBE0 BAHD1 S545 ochoa Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}.
Q8TDM6 DLG5 S1164 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TF72 SHROOM3 S403 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WUM0 NUP133 S594 ochoa Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}.
Q8WYP5 AHCTF1 S506 ochoa Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}.
Q92545 TMEM131 S1179 ochoa Transmembrane protein 131 (Protein RW1) Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}.
Q92610 ZNF592 S529 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92621 NUP205 S1016 ochoa Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}.
Q92900 UPF1 S1084 psp Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250|UniProtKB:Q9EPU0, ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:12554878, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:19417104, ECO:0000269|PubMed:21145460, ECO:0000269|PubMed:21419344, ECO:0000269|PubMed:24726324, ECO:0000269|PubMed:25220460, ECO:0000269|PubMed:30218034}.
Q969G9 NKD1 S317 ochoa Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.
Q96BJ3 AIDA S162 ochoa Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist) Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}.
Q96C57 CUSTOS S58 ochoa Protein CUSTOS Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}.
Q96F46 IL17RA S629 ochoa|psp Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}.
Q96FS4 SIPA1 S79 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q96G01 BICD1 S609 ochoa Protein bicaudal D homolog 1 (Bic-D 1) Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Q96HB5 CCDC120 S360 ochoa Coiled-coil domain-containing protein 120 Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}.
Q96LA6 FCRL1 S67 ochoa Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a) Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Also plays a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q8R4Y0, ECO:0000269|PubMed:15479727}.
Q96PE1 ADGRA2 S1125 ochoa Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}.
Q96PE2 ARHGEF17 S862 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96T58 SPEN S3486 ochoa|psp Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q96TA1 NIBAN2 S728 ochoa Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}.
Q99594 TEAD3 S163 ochoa Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Q99856 ARID3A S371 ochoa AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.
Q99941 ATF6B S564 ochoa Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}.
Q9BT73 PSMG3 S58 ochoa Proteasome assembly chaperone 3 (PAC-3) (hPAC3) (Proteasome chaperone homolog 3) (Pba3) Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes. {ECO:0000269|PubMed:17189198}.
Q9C0H5 ARHGAP39 S406 ochoa Rho GTPase-activating protein 39 None
Q9H0H5 RACGAP1 S257 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H165 BCL11A S327 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H201 EPN3 S503 ochoa Epsin-3 (EPS-15-interacting protein 3) None
Q9H4B6 SAV1 S94 ochoa Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}.
Q9H4B7 TUBB1 S285 ochoa Tubulin beta-1 chain Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9H4G0 EPB41L1 S639 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9NPB6 PARD6A S319 ochoa Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.
Q9NQU5 PAK6 S360 psp Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Q9NQW6 ANLN S536 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NRL2 BAZ1A S1320 ochoa Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.
Q9NRL2 BAZ1A S1339 ochoa Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.
Q9P1Y5 CAMSAP3 S492 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P203 BTBD7 S956 ochoa BTB/POZ domain-containing protein 7 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.
Q9P267 MBD5 S264 ochoa Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:36180891). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:36180891}.
Q9P270 SLAIN2 S413 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UHY8 FEZ2 S65 ochoa Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) Involved in axonal outgrowth and fasciculation. {ECO:0000250}.
Q9UKV0 HDAC9 S239 ochoa|psp Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Q9ULI0 ATAD2B S137 ochoa ATPase family AAA domain-containing protein 2B None
Q9ULI3 HEG1 S1319 ochoa Protein HEG homolog 1 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Q9ULL1 PLEKHG1 S1128 ochoa Pleckstrin homology domain-containing family G member 1 None
Q9UMN6 KMT2B S936 ochoa Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q9UMS6 SYNPO2 S675 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UN70 PCDHGC3 S769 ochoa Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43) Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Q9UNH5 CDC14A S429 psp Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.
Q9UNN5 FAF1 S582 ochoa|psp FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity). {ECO:0000250|UniProtKB:P54731, ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.
Q9UQ35 SRRM2 S1501 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S1693 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQL6 HDAC5 S278 ochoa|psp Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.
Q9Y2I9 TBC1D30 S744 ochoa TBC1 domain family member 30 May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}.
Q9Y3S1 WNK2 S1276 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y446 PKP3 S331 ochoa Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y4F1 FARP1 S896 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4F5 CEP170B S673 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y520 PRRC2C S1983 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y597 KCTD3 S148 ochoa BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}.
Q9Y5I7 CLDN16 S147 psp Claudin-16 (Paracellin-1) (PCLN-1) Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:16234325, PubMed:18188451, PubMed:28028216). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:10390358, PubMed:11518780, PubMed:14628289, PubMed:16528408, PubMed:28028216). {ECO:0000269|PubMed:10390358, ECO:0000269|PubMed:11518780, ECO:0000269|PubMed:14628289, ECO:0000269|PubMed:16234325, ECO:0000269|PubMed:16528408, ECO:0000269|PubMed:18188451, ECO:0000269|PubMed:28028216}.
Q9Y5K6 CD2AP S86 ochoa CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.
P27695 APEX1 S129 Sugiyama DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}.
O75369 FLNB S458 Sugiyama Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Q16600 ZNF239 S46 GPS6 Zinc finger protein 239 (Zinc finger protein HOK-2) (Zinc finger protein MOK-2) May be involved in transcriptional regulation.
O60763 USO1 S32 Sugiyama General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.
P21127 CDK11B Y425 Sugiyama Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}.
Q14028 CNGB1 S958 Sugiyama Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP) Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:34699778). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity) (PubMed:34699778). {ECO:0000250|UniProtKB:A0A8I5ZN27, ECO:0000250|UniProtKB:Q28181, ECO:0000250|UniProtKB:Q9NQW8, ECO:0000269|PubMed:34699778}.; FUNCTION: [Isoform GARP2]: High affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. {ECO:0000269|PubMed:16407240}.
P16452 EPB42 S248 ELM Protein 4.2 (P4.2) (Erythrocyte membrane protein band 4.2) (Erythrocyte protein 4.2) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. {ECO:0000269|PubMed:35835865}.
Q8TD08 MAPK15 S415 Sugiyama Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
Q9UBU9 NXF1 S223 Sugiyama Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:9660949}.
P35916 FLT4 S1235 Sugiyama Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}.
P36894 BMPR1A S218 Sugiyama Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}.
O75534 CSDE1 S766 Sugiyama Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}.
Q32MK0 MYLK3 T426 Sugiyama Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}.
Q6EMK4 VASN S487 Sugiyama Vasorin (Protein slit-like 2) May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}.
Q99829 CPNE1 S130 Sugiyama Copine-1 (Chromobindin 17) (Copine I) Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.
O00410 IPO5 S726 Sugiyama Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.
P62191 PSMC1 S244 Sugiyama 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
O75369 FLNB T1620 Sugiyama Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
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reactome_id name p -log10_p
R-HSA-383280 Nuclear Receptor transcription pathway 1.610599e-07 6.793
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 9.970333e-05 4.001
R-HSA-8939902 Regulation of RUNX2 expression and activity 2.445474e-04 3.612
R-HSA-350054 Notch-HLH transcription pathway 4.424103e-04 3.354
R-HSA-8878166 Transcriptional regulation by RUNX2 1.459745e-03 2.836
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.534379e-03 2.814
R-HSA-212436 Generic Transcription Pathway 1.851468e-03 2.732
R-HSA-73857 RNA Polymerase II Transcription 2.114395e-03 2.675
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 2.604877e-03 2.584
R-HSA-74160 Gene expression (Transcription) 2.372592e-03 2.625
R-HSA-162582 Signal Transduction 2.972454e-03 2.527
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 4.302485e-03 2.366
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 4.556478e-03 2.341
R-HSA-157118 Signaling by NOTCH 5.428685e-03 2.265
R-HSA-2467813 Separation of Sister Chromatids 7.956425e-03 2.099
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 7.600837e-03 2.119
R-HSA-69620 Cell Cycle Checkpoints 8.225729e-03 2.085
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 8.408290e-03 2.075
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 8.408290e-03 2.075
R-HSA-9700645 ALK mutants bind TKIs 9.926195e-03 2.003
R-HSA-68882 Mitotic Anaphase 9.625701e-03 2.017
R-HSA-2555396 Mitotic Metaphase and Anaphase 9.855195e-03 2.006
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.292494e-02 1.889
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 1.329484e-02 1.876
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.382107e-02 1.859
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 1.571707e-02 1.804
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 1.992738e-02 1.701
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.874001e-02 1.727
R-HSA-8941326 RUNX2 regulates bone development 1.671720e-02 1.777
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 1.727784e-02 1.763
R-HSA-453276 Regulation of mitotic cell cycle 1.727784e-02 1.763
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 1.791662e-02 1.747
R-HSA-9013694 Signaling by NOTCH4 1.949899e-02 1.710
R-HSA-1640170 Cell Cycle 1.957932e-02 1.708
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.106758e-02 1.676
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 2.441445e-02 1.612
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 2.441445e-02 1.612
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 2.445052e-02 1.612
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 2.345339e-02 1.630
R-HSA-446353 Cell-extracellular matrix interactions 2.352409e-02 1.628
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 2.585783e-02 1.587
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 2.625482e-02 1.581
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 2.704795e-02 1.568
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 3.079222e-02 1.512
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 3.009789e-02 1.521
R-HSA-141424 Amplification of signal from the kinetochores 3.009789e-02 1.521
R-HSA-5687128 MAPK6/MAPK4 signaling 2.910766e-02 1.536
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 2.828138e-02 1.548
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 3.110786e-02 1.507
R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 3.639835e-02 1.439
R-HSA-5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) 3.639835e-02 1.439
R-HSA-9709603 Impaired BRCA2 binding to PALB2 3.606584e-02 1.443
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 3.882379e-02 1.411
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 3.882379e-02 1.411
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 3.882379e-02 1.411
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 3.882379e-02 1.411
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.290767e-02 1.483
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.439752e-02 1.463
R-HSA-8874177 ATF6B (ATF6-beta) activates chaperones 4.823576e-02 1.317
R-HSA-8941237 Invadopodia formation 5.992848e-02 1.222
R-HSA-1296061 HCN channels 7.147827e-02 1.146
R-HSA-5083630 Defective LFNG causes SCDO3 7.147827e-02 1.146
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 1.052873e-01 0.978
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 1.162825e-01 0.934
R-HSA-110357 Displacement of DNA glycosylase by APEX1 1.162825e-01 0.934
R-HSA-9632974 NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis 1.162825e-01 0.934
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 1.162825e-01 0.934
R-HSA-446107 Type I hemidesmosome assembly 1.271433e-01 0.896
R-HSA-8875656 MET receptor recycling 1.271433e-01 0.896
R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1.271433e-01 0.896
R-HSA-170984 ARMS-mediated activation 1.378712e-01 0.861
R-HSA-8875555 MET activates RAP1 and RAC1 1.484680e-01 0.828
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 5.692243e-02 1.245
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.794869e-01 0.746
R-HSA-9619483 Activation of AMPK downstream of NMDARs 6.687103e-02 1.175
R-HSA-9709570 Impaired BRCA2 binding to RAD51 7.030674e-02 1.153
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 7.379897e-02 1.132
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 7.734581e-02 1.112
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 7.734581e-02 1.112
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 2.093814e-01 0.679
R-HSA-1855170 IPs transport between nucleus and cytosol 8.459597e-02 1.073
R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 2.191034e-01 0.659
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 2.191034e-01 0.659
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 9.583574e-02 1.018
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 2.287064e-01 0.641
R-HSA-3928664 Ephrin signaling 2.475614e-01 0.606
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.475614e-01 0.606
R-HSA-1912420 Pre-NOTCH Processing in Golgi 2.568162e-01 0.590
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 1.276307e-01 0.894
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 2.659578e-01 0.575
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.749874e-01 0.561
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.485862e-01 0.828
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.014186e-01 0.521
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.701721e-01 0.769
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 3.100141e-01 0.509
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.745515e-01 0.758
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 2.749874e-01 0.561
R-HSA-5620916 VxPx cargo-targeting to cilium 2.659578e-01 0.575
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 6.687103e-02 1.175
R-HSA-354192 Integrin signaling 8.459597e-02 1.073
R-HSA-69618 Mitotic Spindle Checkpoint 4.997396e-02 1.301
R-HSA-5610780 Degradation of GLI1 by the proteasome 1.235295e-01 0.908
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 9.204286e-02 1.036
R-HSA-76009 Platelet Aggregation (Plug Formation) 1.401194e-01 0.854
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.405489e-02 1.356
R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 1.895747e-01 0.722
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.674465e-01 0.776
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.594218e-01 0.444
R-HSA-5693607 Processing of DNA double-strand break ends 9.905136e-02 1.004
R-HSA-5693537 Resolution of D-Loop Structures 8.829570e-02 1.054
R-HSA-8849473 PTK6 Expression 1.162825e-01 0.934
R-HSA-420029 Tight junction interactions 5.692243e-02 1.245
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 8.459597e-02 1.073
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 8.459597e-02 1.073
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 2.287064e-01 0.641
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.578252e-02 1.339
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 2.475614e-01 0.606
R-HSA-389977 Post-chaperonin tubulin folding pathway 2.659578e-01 0.575
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 1.745515e-01 0.758
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.051702e-01 0.688
R-HSA-204005 COPII-mediated vesicle transport 2.509379e-01 0.600
R-HSA-77595 Processing of Intronless Pre-mRNAs 2.287064e-01 0.641
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 2.839065e-01 0.547
R-HSA-5685942 HDR through Homologous Recombination (HRR) 2.372907e-01 0.625
R-HSA-4608870 Asymmetric localization of PCP proteins 1.401194e-01 0.854
R-HSA-5693538 Homology Directed Repair 2.243499e-01 0.649
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 3.281438e-01 0.484
R-HSA-199977 ER to Golgi Anterograde Transport 3.339471e-01 0.476
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 3.268908e-01 0.486
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 1.052873e-01 0.978
R-HSA-428543 Inactivation of CDC42 and RAC1 1.378712e-01 0.861
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1.484680e-01 0.828
R-HSA-192905 vRNP Assembly 1.589351e-01 0.799
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 2.191034e-01 0.659
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 9.204286e-02 1.036
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 9.204286e-02 1.036
R-HSA-180910 Vpr-mediated nuclear import of PICs 1.035520e-01 0.985
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2.381920e-01 0.623
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 2.475614e-01 0.606
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.401194e-01 0.854
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 1.389680e-01 0.857
R-HSA-9924644 Developmental Lineages of the Mammary Gland 2.600493e-01 0.585
R-HSA-201451 Signaling by BMP 3.351745e-01 0.475
R-HSA-9006931 Signaling by Nuclear Receptors 3.367481e-01 0.473
R-HSA-1500620 Meiosis 3.191288e-01 0.496
R-HSA-9009391 Extra-nuclear estrogen signaling 1.621526e-01 0.790
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 1.833633e-01 0.737
R-HSA-3295583 TRP channels 3.268908e-01 0.486
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 1.864014e-01 0.730
R-HSA-5693532 DNA Double-Strand Break Repair 1.629566e-01 0.788
R-HSA-5610787 Hedgehog 'off' state 4.997396e-02 1.301
R-HSA-5632684 Hedgehog 'on' state 7.553727e-02 1.122
R-HSA-139915 Activation of PUMA and translocation to mitochondria 1.162825e-01 0.934
R-HSA-171007 p38MAPK events 2.093814e-01 0.679
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 8.829570e-02 1.054
R-HSA-2028269 Signaling by Hippo 2.381920e-01 0.623
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.074721e-01 0.969
R-HSA-912446 Meiotic recombination 1.658120e-01 0.780
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 1.701721e-01 0.769
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 2.146515e-01 0.668
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.554928e-01 0.593
R-HSA-9907900 Proteasome assembly 1.359270e-01 0.867
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 2.011692e-01 0.696
R-HSA-525793 Myogenesis 3.268908e-01 0.486
R-HSA-5358351 Signaling by Hedgehog 1.270486e-01 0.896
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 8.288685e-02 1.082
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 9.415596e-02 1.026
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 2.381920e-01 0.623
R-HSA-190872 Transport of connexons to the plasma membrane 2.475614e-01 0.606
R-HSA-191859 snRNP Assembly 2.011692e-01 0.696
R-HSA-194441 Metabolism of non-coding RNA 2.011692e-01 0.696
R-HSA-168325 Viral Messenger RNA Synthesis 2.101472e-01 0.677
R-HSA-68877 Mitotic Prometaphase 1.240914e-01 0.906
R-HSA-169893 Prolonged ERK activation events 2.191034e-01 0.659
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 3.100141e-01 0.509
R-HSA-5693606 DNA Double Strand Break Response 2.372907e-01 0.625
R-HSA-8934903 Receptor Mediated Mitophagy 1.484680e-01 0.828
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.995390e-01 0.700
R-HSA-180746 Nuclear import of Rev protein 9.204286e-02 1.036
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 9.583574e-02 1.018
R-HSA-6784531 tRNA processing in the nucleus 5.683706e-02 1.245
R-HSA-912631 Regulation of signaling by CBL 2.568162e-01 0.590
R-HSA-8856688 Golgi-to-ER retrograde transport 2.769354e-01 0.558
R-HSA-1912422 Pre-NOTCH Expression and Processing 2.020114e-01 0.695
R-HSA-5689603 UCH proteinases 2.782779e-01 0.556
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.646068e-01 0.577
R-HSA-194313 VEGF ligand-receptor interactions 9.415596e-02 1.026
R-HSA-428540 Activation of RAC1 1.692743e-01 0.771
R-HSA-8951936 RUNX3 regulates p14-ARF 1.794869e-01 0.746
R-HSA-446205 Synthesis of GDP-mannose 1.794869e-01 0.746
R-HSA-2485179 Activation of the phototransduction cascade 2.191034e-01 0.659
R-HSA-187687 Signalling to ERKs 9.583574e-02 1.018
R-HSA-177243 Interactions of Rev with host cellular proteins 1.154285e-01 0.938
R-HSA-176033 Interactions of Vpr with host cellular proteins 1.154285e-01 0.938
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.194617e-01 0.923
R-HSA-69473 G2/M DNA damage checkpoint 8.230318e-02 1.085
R-HSA-68886 M Phase 6.434833e-02 1.191
R-HSA-448424 Interleukin-17 signaling 2.509379e-01 0.600
R-HSA-9768777 Regulation of NPAS4 gene transcription 1.378712e-01 0.861
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 3.594218e-01 0.444
R-HSA-983189 Kinesins 2.056528e-01 0.687
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 2.146515e-01 0.668
R-HSA-6794361 Neurexins and neuroligins 1.701721e-01 0.769
R-HSA-1632852 Macroautophagy 1.335057e-01 0.875
R-HSA-9675135 Diseases of DNA repair 1.443396e-01 0.841
R-HSA-450341 Activation of the AP-1 family of transcription factors 1.378712e-01 0.861
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 2.093814e-01 0.679
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 2.191034e-01 0.659
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.074721e-01 0.969
R-HSA-167044 Signalling to RAS 2.749874e-01 0.561
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.443396e-01 0.841
R-HSA-5578749 Transcriptional regulation by small RNAs 2.600493e-01 0.585
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 3.351745e-01 0.475
R-HSA-9768759 Regulation of NPAS4 gene expression 2.381920e-01 0.623
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 1.401194e-01 0.854
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 1.401194e-01 0.854
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.418361e-01 0.616
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 9.171376e-02 1.038
R-HSA-9612973 Autophagy 1.700663e-01 0.769
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.895747e-01 0.722
R-HSA-9018681 Biosynthesis of protectins 1.995390e-01 0.700
R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.114314e-01 0.953
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 8.932045e-02 1.049
R-HSA-5689901 Metalloprotease DUBs 3.268908e-01 0.486
R-HSA-69481 G2/M Checkpoints 1.006998e-01 0.997
R-HSA-4086400 PCP/CE pathway 2.873841e-01 0.542
R-HSA-8878171 Transcriptional regulation by RUNX1 1.902454e-01 0.721
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 3.351745e-01 0.475
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 3.236400e-01 0.490
R-HSA-373753 Nephrin family interactions 2.659578e-01 0.575
R-HSA-2980766 Nuclear Envelope Breakdown 1.922386e-01 0.716
R-HSA-9932444 ATP-dependent chromatin remodelers 3.185044e-01 0.497
R-HSA-9932451 SWI/SNF chromatin remodelers 3.185044e-01 0.497
R-HSA-69278 Cell Cycle, Mitotic 6.208368e-02 1.207
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 6.687103e-02 1.175
R-HSA-9027307 Biosynthesis of maresin-like SPMs 2.287064e-01 0.641
R-HSA-392517 Rap1 signalling 2.568162e-01 0.590
R-HSA-198753 ERK/MAPK targets 2.749874e-01 0.561
R-HSA-193648 NRAGE signals death through JNK 1.877935e-01 0.726
R-HSA-174414 Processive synthesis on the C-strand of the telomere 3.351745e-01 0.475
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 2.405919e-01 0.619
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 3.574474e-01 0.447
R-HSA-70171 Glycolysis 1.591923e-01 0.798
R-HSA-162909 Host Interactions of HIV factors 2.438644e-01 0.613
R-HSA-8878159 Transcriptional regulation by RUNX3 1.504150e-01 0.823
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 1.378712e-01 0.861
R-HSA-1169408 ISG15 antiviral mechanism 8.461480e-02 1.073
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 3.514388e-01 0.454
R-HSA-6794362 Protein-protein interactions at synapses 3.191288e-01 0.496
R-HSA-194138 Signaling by VEGF 9.689487e-02 1.014
R-HSA-4420097 VEGFA-VEGFR2 Pathway 2.147135e-01 0.668
R-HSA-430116 GP1b-IX-V activation signalling 1.378712e-01 0.861
R-HSA-9663891 Selective autophagy 3.371267e-01 0.472
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specif... 2.927165e-01 0.534
R-HSA-114452 Activation of BH3-only proteins 3.594218e-01 0.444
R-HSA-69275 G2/M Transition 2.489337e-01 0.604
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.692743e-01 0.771
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 1.895747e-01 0.722
R-HSA-199418 Negative regulation of the PI3K/AKT network 2.669570e-01 0.574
R-HSA-453274 Mitotic G2-G2/M phases 2.542882e-01 0.595
R-HSA-381042 PERK regulates gene expression 9.583574e-02 1.018
R-HSA-69615 G1/S DNA Damage Checkpoints 2.191648e-01 0.659
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 3.100858e-01 0.509
R-HSA-68875 Mitotic Prophase 2.308213e-01 0.637
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 3.171388e-01 0.499
R-HSA-1912408 Pre-NOTCH Transcription and Translation 1.278364e-01 0.893
R-HSA-9018682 Biosynthesis of maresins 3.014186e-01 0.521
R-HSA-5669034 TNFs bind their physiological receptors 3.100141e-01 0.509
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 2.600493e-01 0.585
R-HSA-438064 Post NMDA receptor activation events 3.326395e-01 0.478
R-HSA-8848021 Signaling by PTK6 2.191648e-01 0.659
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 2.191648e-01 0.659
R-HSA-70326 Glucose metabolism 2.211281e-01 0.655
R-HSA-3700989 Transcriptional Regulation by TP53 1.501960e-01 0.823
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.359270e-01 0.867
R-HSA-8983711 OAS antiviral response 1.794869e-01 0.746
R-HSA-3000170 Syndecan interactions 3.014186e-01 0.521
R-HSA-3000157 Laminin interactions 3.185044e-01 0.497
R-HSA-416482 G alpha (12/13) signalling events 2.873841e-01 0.542
R-HSA-1500931 Cell-Cell communication 1.249447e-01 0.903
R-HSA-446728 Cell junction organization 1.656852e-01 0.781
R-HSA-8953750 Transcriptional Regulation by E2F6 1.114314e-01 0.953
R-HSA-381119 Unfolded Protein Response (UPR) 3.037031e-01 0.518
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 3.268908e-01 0.486
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.646068e-01 0.577
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.298624e-01 0.887
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 6.366983e-02 1.196
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 1.966975e-01 0.706
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 5.302263e-02 1.276
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 5.302263e-02 1.276
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 5.302263e-02 1.276
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 5.302263e-02 1.276
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.922386e-01 0.716
R-HSA-2219528 PI3K/AKT Signaling in Cancer 2.243499e-01 0.649
R-HSA-9614085 FOXO-mediated transcription 1.562490e-01 0.806
R-HSA-1257604 PIP3 activates AKT signaling 3.500065e-01 0.456
R-HSA-5633007 Regulation of TP53 Activity 7.138217e-02 1.146
R-HSA-2644603 Signaling by NOTCH1 in Cancer 5.302263e-02 1.276
R-HSA-1980143 Signaling by NOTCH1 8.695401e-02 1.061
R-HSA-73887 Death Receptor Signaling 3.574474e-01 0.447
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.607974e-01 0.443
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 3.673071e-01 0.435
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 3.673071e-01 0.435
R-HSA-399719 Trafficking of AMPA receptors 3.673071e-01 0.435
R-HSA-5694530 Cargo concentration in the ER 3.673071e-01 0.435
R-HSA-186763 Downstream signal transduction 3.673071e-01 0.435
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 3.750958e-01 0.426
R-HSA-6807878 COPI-mediated anterograde transport 3.814351e-01 0.419
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 3.814351e-01 0.419
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 3.827891e-01 0.417
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 3.827891e-01 0.417
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 3.827891e-01 0.417
R-HSA-109581 Apoptosis 3.841653e-01 0.415
R-HSA-8957275 Post-translational protein phosphorylation 3.901530e-01 0.409
R-HSA-390522 Striated Muscle Contraction 3.903881e-01 0.409
R-HSA-180534 Vpu mediated degradation of CD4 3.903881e-01 0.409
R-HSA-8939211 ESR-mediated signaling 3.924442e-01 0.406
R-HSA-3214847 HATs acetylate histones 3.944916e-01 0.404
R-HSA-193704 p75 NTR receptor-mediated signalling 3.944916e-01 0.404
R-HSA-1980145 Signaling by NOTCH2 3.978941e-01 0.400
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 3.978941e-01 0.400
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 3.978941e-01 0.400
R-HSA-190861 Gap junction assembly 3.978941e-01 0.400
R-HSA-5205647 Mitophagy 3.978941e-01 0.400
R-HSA-168638 NOD1/2 Signaling Pathway 3.978941e-01 0.400
R-HSA-5619102 SLC transporter disorders 4.007416e-01 0.397
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 4.053081e-01 0.392
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 4.053081e-01 0.392
R-HSA-169911 Regulation of Apoptosis 4.053081e-01 0.392
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 4.074224e-01 0.390
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 4.074224e-01 0.390
R-HSA-180585 Vif-mediated degradation of APOBEC3G 4.126312e-01 0.384
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 4.126312e-01 0.384
R-HSA-72306 tRNA processing 4.139144e-01 0.383
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 4.198647e-01 0.377
R-HSA-4641258 Degradation of DVL 4.198647e-01 0.377
R-HSA-4641257 Degradation of AXIN 4.198647e-01 0.377
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 4.198647e-01 0.377
R-HSA-5689896 Ovarian tumor domain proteases 4.198647e-01 0.377
R-HSA-5619115 Disorders of transmembrane transporters 4.201179e-01 0.377
R-HSA-9909648 Regulation of PD-L1(CD274) expression 4.204674e-01 0.376
R-HSA-4839726 Chromatin organization 4.256208e-01 0.371
R-HSA-8875878 MET promotes cell motility 4.270094e-01 0.370
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 4.302512e-01 0.366
R-HSA-9700206 Signaling by ALK in cancer 4.328749e-01 0.364
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.328749e-01 0.364
R-HSA-211000 Gene Silencing by RNA 4.328749e-01 0.364
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 4.340667e-01 0.362
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 4.340667e-01 0.362
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 4.340667e-01 0.362
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 4.340667e-01 0.362
R-HSA-69541 Stabilization of p53 4.340667e-01 0.362
R-HSA-2672351 Stimuli-sensing channels 4.370608e-01 0.359
R-HSA-9646399 Aggrephagy 4.410374e-01 0.356
R-HSA-1251985 Nuclear signaling by ERBB4 4.410374e-01 0.356
R-HSA-9604323 Negative regulation of NOTCH4 signaling 4.410374e-01 0.356
R-HSA-8941858 Regulation of RUNX3 expression and activity 4.410374e-01 0.356
R-HSA-5688426 Deubiquitination 4.420493e-01 0.355
R-HSA-168255 Influenza Infection 4.432040e-01 0.353
R-HSA-73933 Resolution of Abasic Sites (AP sites) 4.479227e-01 0.349
R-HSA-5423646 Aflatoxin activation and detoxification 4.479227e-01 0.349
R-HSA-5362768 Hh mutants are degraded by ERAD 4.479227e-01 0.349
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 4.479227e-01 0.349
R-HSA-3214841 PKMTs methylate histone lysines 4.479227e-01 0.349
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 4.479227e-01 0.349
R-HSA-1483249 Inositol phosphate metabolism 4.536357e-01 0.343
R-HSA-5674135 MAP2K and MAPK activation 4.547236e-01 0.342
R-HSA-9656223 Signaling by RAF1 mutants 4.547236e-01 0.342
R-HSA-9932298 Degradation of CRY and PER proteins 4.547236e-01 0.342
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 4.547236e-01 0.342
R-HSA-5610783 Degradation of GLI2 by the proteasome 4.547236e-01 0.342
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 4.547236e-01 0.342
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 4.547236e-01 0.342
R-HSA-165159 MTOR signalling 4.614412e-01 0.336
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 4.614412e-01 0.336
R-HSA-9734767 Developmental Cell Lineages 4.637349e-01 0.334
R-HSA-9006925 Intracellular signaling by second messengers 4.638966e-01 0.334
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 4.658836e-01 0.332
R-HSA-5387390 Hh mutants abrogate ligand secretion 4.680764e-01 0.330
R-HSA-8854214 TBC/RABGAPs 4.680764e-01 0.330
R-HSA-3928662 EPHB-mediated forward signaling 4.746303e-01 0.324
R-HSA-190828 Gap junction trafficking 4.746303e-01 0.324
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 4.746303e-01 0.324
R-HSA-156581 Methylation 4.746303e-01 0.324
R-HSA-5683057 MAPK family signaling cascades 4.757610e-01 0.323
R-HSA-5678895 Defective CFTR causes cystic fibrosis 4.811038e-01 0.318
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 4.811038e-01 0.318
R-HSA-9824272 Somitogenesis 4.811038e-01 0.318
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 4.874979e-01 0.312
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 4.874979e-01 0.312
R-HSA-9649948 Signaling downstream of RAS mutants 4.874979e-01 0.312
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 4.874979e-01 0.312
R-HSA-6802949 Signaling by RAS mutants 4.874979e-01 0.312
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 4.874979e-01 0.312
R-HSA-5357905 Regulation of TNFR1 signaling 4.874979e-01 0.312
R-HSA-76002 Platelet activation, signaling and aggregation 4.930581e-01 0.307
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 4.938137e-01 0.306
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 4.938137e-01 0.306
R-HSA-437239 Recycling pathway of L1 4.938137e-01 0.306
R-HSA-9609690 HCMV Early Events 4.968671e-01 0.304
R-HSA-3371556 Cellular response to heat stress 4.977379e-01 0.303
R-HSA-5620924 Intraflagellar transport 5.000520e-01 0.301
R-HSA-2132295 MHC class II antigen presentation 5.055116e-01 0.296
R-HSA-73894 DNA Repair 5.061930e-01 0.296
R-HSA-157858 Gap junction trafficking and regulation 5.062138e-01 0.296
R-HSA-9766229 Degradation of CDH1 5.062138e-01 0.296
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 5.062138e-01 0.296
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 5.062138e-01 0.296
R-HSA-69563 p53-Dependent G1 DNA Damage Response 5.062138e-01 0.296
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 5.091225e-01 0.293
R-HSA-389948 Co-inhibition by PD-1 5.091225e-01 0.293
R-HSA-5658442 Regulation of RAS by GAPs 5.123000e-01 0.290
R-HSA-948021 Transport to the Golgi and subsequent modification 5.151920e-01 0.288
R-HSA-376176 Signaling by ROBO receptors 5.182118e-01 0.285
R-HSA-2514856 The phototransduction cascade 5.183116e-01 0.285
R-HSA-1169091 Activation of NF-kappaB in B cells 5.183116e-01 0.285
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5.183116e-01 0.285
R-HSA-5358346 Hedgehog ligand biogenesis 5.183116e-01 0.285
R-HSA-2262752 Cellular responses to stress 5.223158e-01 0.282
R-HSA-72187 mRNA 3'-end processing 5.242494e-01 0.280
R-HSA-68949 Orc1 removal from chromatin 5.242494e-01 0.280
R-HSA-9634815 Transcriptional Regulation by NPAS4 5.242494e-01 0.280
R-HSA-114608 Platelet degranulation 5.246030e-01 0.280
R-HSA-5357801 Programmed Cell Death 5.272108e-01 0.278
R-HSA-187037 Signaling by NTRK1 (TRKA) 5.283617e-01 0.277
R-HSA-1221632 Meiotic synapsis 5.301144e-01 0.276
R-HSA-9639288 Amino acids regulate mTORC1 5.301144e-01 0.276
R-HSA-8948751 Regulation of PTEN stability and activity 5.301144e-01 0.276
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 5.359075e-01 0.271
R-HSA-1474165 Reproduction 5.395172e-01 0.268
R-HSA-9909396 Circadian clock 5.468530e-01 0.262
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 5.472813e-01 0.262
R-HSA-177929 Signaling by EGFR 5.472813e-01 0.262
R-HSA-109606 Intrinsic Pathway for Apoptosis 5.472813e-01 0.262
R-HSA-75893 TNF signaling 5.472813e-01 0.262
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 5.478437e-01 0.261
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 5.504903e-01 0.259
R-HSA-9764561 Regulation of CDH1 Function 5.528638e-01 0.257
R-HSA-913531 Interferon Signaling 5.604279e-01 0.251
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 5.638241e-01 0.249
R-HSA-180786 Extension of Telomeres 5.638241e-01 0.249
R-HSA-9018519 Estrogen-dependent gene expression 5.648347e-01 0.248
R-HSA-3858494 Beta-catenin independent WNT signaling 5.648347e-01 0.248
R-HSA-8943724 Regulation of PTEN gene transcription 5.692036e-01 0.245
R-HSA-351202 Metabolism of polyamines 5.692036e-01 0.245
R-HSA-73856 RNA Polymerase II Transcription Termination 5.745170e-01 0.241
R-HSA-450294 MAP kinase activation 5.745170e-01 0.241
R-HSA-9793380 Formation of paraxial mesoderm 5.745170e-01 0.241
R-HSA-6807070 PTEN Regulation 5.753768e-01 0.240
R-HSA-9707616 Heme signaling 5.797653e-01 0.237
R-HSA-186797 Signaling by PDGF 5.797653e-01 0.237
R-HSA-8953897 Cellular responses to stimuli 5.836994e-01 0.234
R-HSA-373755 Semaphorin interactions 5.849491e-01 0.233
R-HSA-199991 Membrane Trafficking 5.873383e-01 0.231
R-HSA-162599 Late Phase of HIV Life Cycle 5.891429e-01 0.230
R-HSA-211981 Xenobiotics 5.900693e-01 0.229
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 5.900693e-01 0.229
R-HSA-162906 HIV Infection 5.902404e-01 0.229
R-HSA-9705683 SARS-CoV-2-host interactions 5.929751e-01 0.227
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 5.951267e-01 0.225
R-HSA-1234174 Cellular response to hypoxia 5.951267e-01 0.225
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 6.001220e-01 0.222
R-HSA-3247509 Chromatin modifying enzymes 6.091362e-01 0.215
R-HSA-166520 Signaling by NTRKs 6.091694e-01 0.215
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 6.099293e-01 0.215
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 6.099293e-01 0.215
R-HSA-9856651 MITF-M-dependent gene expression 6.156788e-01 0.211
R-HSA-8953854 Metabolism of RNA 6.170860e-01 0.210
R-HSA-9755511 KEAP1-NFE2L2 pathway 6.189024e-01 0.208
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 6.194972e-01 0.208
R-HSA-69202 Cyclin E associated events during G1/S transition 6.194972e-01 0.208
R-HSA-195253 Degradation of beta-catenin by the destruction complex 6.194972e-01 0.208
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 6.241933e-01 0.205
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.288317e-01 0.201
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 6.288317e-01 0.201
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 6.334131e-01 0.198
R-HSA-69052 Switching of origins to a post-replicative state 6.334131e-01 0.198
R-HSA-9610379 HCMV Late Events 6.378097e-01 0.195
R-HSA-162587 HIV Life Cycle 6.378097e-01 0.195
R-HSA-1236394 Signaling by ERBB4 6.379382e-01 0.195
R-HSA-446203 Asparagine N-linked glycosylation 6.417368e-01 0.193
R-HSA-380287 Centrosome maturation 6.424078e-01 0.192
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 6.424078e-01 0.192
R-HSA-71403 Citric acid cycle (TCA cycle) 6.424078e-01 0.192
R-HSA-3000171 Non-integrin membrane-ECM interactions 6.424078e-01 0.192
R-HSA-9006936 Signaling by TGFB family members 6.469855e-01 0.189
R-HSA-9609646 HCMV Infection 6.501168e-01 0.187
R-HSA-421270 Cell-cell junction organization 6.525746e-01 0.185
R-HSA-5619084 ABC transporter disorders 6.554898e-01 0.183
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 6.597437e-01 0.181
R-HSA-9659379 Sensory processing of sound 6.597437e-01 0.181
R-HSA-6806834 Signaling by MET 6.639454e-01 0.178
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 6.639454e-01 0.178
R-HSA-9833482 PKR-mediated signaling 6.639454e-01 0.178
R-HSA-388841 Regulation of T cell activation by CD28 family 6.646794e-01 0.177
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 6.680954e-01 0.175
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.802421e-01 0.167
R-HSA-6802957 Oncogenic MAPK signaling 6.841919e-01 0.165
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 6.880931e-01 0.162
R-HSA-390466 Chaperonin-mediated protein folding 6.957523e-01 0.158
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 6.995115e-01 0.155
R-HSA-422475 Axon guidance 7.031696e-01 0.153
R-HSA-1236974 ER-Phagosome pathway 7.032244e-01 0.153
R-HSA-73884 Base Excision Repair 7.068916e-01 0.151
R-HSA-202424 Downstream TCR signaling 7.068916e-01 0.151
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 7.140914e-01 0.146
R-HSA-2682334 EPH-Ephrin signaling 7.176251e-01 0.144
R-HSA-391251 Protein folding 7.176251e-01 0.144
R-HSA-68867 Assembly of the pre-replicative complex 7.211153e-01 0.142
R-HSA-1474290 Collagen formation 7.245625e-01 0.140
R-HSA-112316 Neuronal System 7.248179e-01 0.140
R-HSA-983712 Ion channel transport 7.288624e-01 0.137
R-HSA-5617833 Cilium Assembly 7.312936e-01 0.136
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 7.313303e-01 0.136
R-HSA-1296071 Potassium Channels 7.346519e-01 0.134
R-HSA-5607764 CLEC7A (Dectin-1) signaling 7.346519e-01 0.134
R-HSA-170834 Signaling by TGF-beta Receptor Complex 7.379327e-01 0.132
R-HSA-157579 Telomere Maintenance 7.379327e-01 0.132
R-HSA-975871 MyD88 cascade initiated on plasma membrane 7.411731e-01 0.130
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 7.411731e-01 0.130
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 7.411731e-01 0.130
R-HSA-382556 ABC-family proteins mediated transport 7.475347e-01 0.126
R-HSA-9020702 Interleukin-1 signaling 7.506570e-01 0.125
R-HSA-2559580 Oxidative Stress Induced Senescence 7.537408e-01 0.123
R-HSA-9675108 Nervous system development 7.584484e-01 0.120
R-HSA-9860931 Response of endothelial cells to shear stress 7.597950e-01 0.119
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 7.657012e-01 0.116
R-HSA-69239 Synthesis of DNA 7.714628e-01 0.113
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 7.742905e-01 0.111
R-HSA-1236975 Antigen processing-Cross presentation 7.742905e-01 0.111
R-HSA-975155 MyD88 dependent cascade initiated on endosome 7.770834e-01 0.110
R-HSA-69002 DNA Replication Pre-Initiation 7.770834e-01 0.110
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 7.798420e-01 0.108
R-HSA-166166 MyD88-independent TLR4 cascade 7.798420e-01 0.108
R-HSA-202403 TCR signaling 7.798420e-01 0.108
R-HSA-9730414 MITF-M-regulated melanocyte development 7.843108e-01 0.106
R-HSA-927802 Nonsense-Mediated Decay (NMD) 7.852575e-01 0.105
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 7.852575e-01 0.105
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 7.879154e-01 0.104
R-HSA-9855142 Cellular responses to mechanical stimuli 7.905405e-01 0.102
R-HSA-1852241 Organelle biogenesis and maintenance 7.930834e-01 0.101
R-HSA-5628897 TP53 Regulates Metabolic Genes 7.956942e-01 0.099
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 7.956942e-01 0.099
R-HSA-212165 Epigenetic regulation of gene expression 7.979534e-01 0.098
R-HSA-112315 Transmission across Chemical Synapses 7.979534e-01 0.098
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 7.986972e-01 0.098
R-HSA-8951664 Neddylation 7.998364e-01 0.097
R-HSA-373760 L1CAM interactions 8.007217e-01 0.097
R-HSA-9007101 Rab regulation of trafficking 8.031891e-01 0.095
R-HSA-1592230 Mitochondrial biogenesis 8.031891e-01 0.095
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 8.080330e-01 0.093
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 8.080330e-01 0.093
R-HSA-5653656 Vesicle-mediated transport 8.081563e-01 0.093
R-HSA-73886 Chromosome Maintenance 8.127583e-01 0.090
R-HSA-9759194 Nuclear events mediated by NFE2L2 8.127583e-01 0.090
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 8.150774e-01 0.089
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 8.150774e-01 0.089
R-HSA-6809371 Formation of the cornified envelope 8.196302e-01 0.086
R-HSA-977606 Regulation of Complement cascade 8.218646e-01 0.085
R-HSA-69206 G1/S Transition 8.240714e-01 0.084
R-HSA-9694516 SARS-CoV-2 Infection 8.362815e-01 0.078
R-HSA-597592 Post-translational protein modification 8.386118e-01 0.076
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 8.387760e-01 0.076
R-HSA-6798695 Neutrophil degranulation 8.443822e-01 0.073
R-HSA-9948299 Ribosome-associated quality control 8.540892e-01 0.068
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.576857e-01 0.067
R-HSA-9664407 Parasite infection 8.576857e-01 0.067
R-HSA-9664417 Leishmania phagocytosis 8.576857e-01 0.067
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 8.594508e-01 0.066
R-HSA-8856828 Clathrin-mediated endocytosis 8.646163e-01 0.063
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 8.646163e-01 0.063
R-HSA-2871837 FCERI mediated NF-kB activation 8.662958e-01 0.062
R-HSA-166658 Complement cascade 8.679546e-01 0.062
R-HSA-453279 Mitotic G1 phase and G1/S transition 8.695929e-01 0.061
R-HSA-2187338 Visual phototransduction 8.712110e-01 0.060
R-HSA-9711123 Cellular response to chemical stress 8.725538e-01 0.059
R-HSA-69242 S Phase 8.728091e-01 0.059
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 8.728091e-01 0.059
R-HSA-109582 Hemostasis 8.730036e-01 0.059
R-HSA-9758941 Gastrulation 8.743874e-01 0.058
R-HSA-1280215 Cytokine Signaling in Immune system 8.752910e-01 0.058
R-HSA-9679191 Potential therapeutics for SARS 8.759463e-01 0.058
R-HSA-2142753 Arachidonate metabolism 8.790065e-01 0.056
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 8.790065e-01 0.056
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.790065e-01 0.056
R-HSA-446652 Interleukin-1 family signaling 8.790065e-01 0.056
R-HSA-69306 DNA Replication 8.805084e-01 0.055
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 8.863325e-01 0.052
R-HSA-9711097 Cellular response to starvation 8.877438e-01 0.052
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 8.877438e-01 0.052
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.889983e-01 0.051
R-HSA-5673001 RAF/MAP kinase cascade 8.964653e-01 0.047
R-HSA-211897 Cytochrome P450 - arranged by substrate type 8.996864e-01 0.046
R-HSA-5684996 MAPK1/MAPK3 signaling 9.034649e-01 0.044
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 9.045800e-01 0.044
R-HSA-195721 Signaling by WNT 9.053825e-01 0.043
R-HSA-5621481 C-type lectin receptors (CLRs) 9.057658e-01 0.043
R-HSA-5689880 Ub-specific processing proteases 9.080936e-01 0.042
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 9.080936e-01 0.042
R-HSA-9764265 Regulation of CDH1 Expression and Function 9.080936e-01 0.042
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 9.092359e-01 0.041
R-HSA-2559583 Cellular Senescence 9.157994e-01 0.038
R-HSA-201681 TCF dependent signaling in response to WNT 9.189018e-01 0.037
R-HSA-3781865 Diseases of glycosylation 9.199104e-01 0.036
R-HSA-375276 Peptide ligand-binding receptors 9.218904e-01 0.035
R-HSA-8868773 rRNA processing in the nucleus and cytosol 9.238217e-01 0.034
R-HSA-168898 Toll-like Receptor Cascades 9.266299e-01 0.033
R-HSA-9679506 SARS-CoV Infections 9.277891e-01 0.033
R-HSA-72163 mRNA Splicing - Major Pathway 9.293351e-01 0.032
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 9.310832e-01 0.031
R-HSA-1474244 Extracellular matrix organization 9.323144e-01 0.030
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.353438e-01 0.029
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 9.368695e-01 0.028
R-HSA-1483206 Glycerophospholipid biosynthesis 9.368695e-01 0.028
R-HSA-72172 mRNA Splicing 9.384320e-01 0.028
R-HSA-6805567 Keratinization 9.399561e-01 0.027
R-HSA-397014 Muscle contraction 9.443068e-01 0.025
R-HSA-418990 Adherens junctions interactions 9.483437e-01 0.023
R-HSA-72312 rRNA processing 9.566664e-01 0.019
R-HSA-449147 Signaling by Interleukins 9.600173e-01 0.018
R-HSA-156580 Phase II - Conjugation of compounds 9.603128e-01 0.018
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.610145e-01 0.017
R-HSA-211945 Phase I - Functionalization of compounds 9.756973e-01 0.011
R-HSA-9824443 Parasitic Infection Pathways 9.765983e-01 0.010
R-HSA-9658195 Leishmania infection 9.765983e-01 0.010
R-HSA-1280218 Adaptive Immune System 9.799900e-01 0.009
R-HSA-1483257 Phospholipid metabolism 9.803825e-01 0.009
R-HSA-1428517 Aerobic respiration and respiratory electron transport 9.890233e-01 0.005
R-HSA-9824446 Viral Infection Pathways 9.895106e-01 0.005
R-HSA-1266738 Developmental Biology 9.937869e-01 0.003
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 9.944602e-01 0.002
R-HSA-418594 G alpha (i) signalling events 9.953027e-01 0.002
R-HSA-8978868 Fatty acid metabolism 9.953027e-01 0.002
R-HSA-5668914 Diseases of metabolism 9.963566e-01 0.002
R-HSA-72766 Translation 9.964480e-01 0.002
R-HSA-388396 GPCR downstream signalling 9.972856e-01 0.001
R-HSA-392499 Metabolism of proteins 9.979074e-01 0.001
R-HSA-168249 Innate Immune System 9.981470e-01 0.001
R-HSA-1643685 Disease 9.981780e-01 0.001
R-HSA-372790 Signaling by GPCR 9.988870e-01 0.000
R-HSA-211859 Biological oxidations 9.989287e-01 0.000
R-HSA-168256 Immune System 9.993403e-01 0.000
R-HSA-500792 GPCR ligand binding 9.995403e-01 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 9.996833e-01 0.000
R-HSA-382551 Transport of small molecules 9.997170e-01 0.000
R-HSA-5663205 Infectious disease 9.997985e-01 0.000
R-HSA-9709957 Sensory Perception 9.999851e-01 0.000
R-HSA-381753 Olfactory Signaling Pathway 9.999873e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999999e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK4HIPK4 0.814 0.240 1 0.753
MARK4MARK4 0.812 0.414 4 0.559
QSKQSK 0.811 0.418 4 0.592
MARK3MARK3 0.809 0.471 4 0.656
AMPKA1AMPKA1 0.807 0.326 -3 0.895
MARK2MARK2 0.806 0.454 4 0.638
AURCAURC 0.805 0.186 -2 0.806
AMPKA2AMPKA2 0.804 0.297 -3 0.875
PRKD1PRKD1 0.803 0.147 -3 0.882
CDC7CDC7 0.803 0.122 1 0.828
SIKSIK 0.801 0.333 -3 0.828
PIM3PIM3 0.801 0.118 -3 0.884
CDKL5CDKL5 0.801 0.134 -3 0.877
PRKD2PRKD2 0.800 0.154 -3 0.848
CLK3CLK3 0.799 0.116 1 0.789
NDR2NDR2 0.799 0.078 -3 0.875
TSSK1TSSK1 0.799 0.241 -3 0.908
SKMLCKSKMLCK 0.797 0.155 -2 0.939
NUAK2NUAK2 0.796 0.157 -3 0.894
COTCOT 0.795 -0.045 2 0.594
CAMK1BCAMK1B 0.795 0.125 -3 0.910
CDKL1CDKL1 0.794 0.108 -3 0.879
RSK3RSK3 0.794 0.115 -3 0.849
MARK1MARK1 0.794 0.377 4 0.604
NDR1NDR1 0.793 0.082 -3 0.882
BRSK2BRSK2 0.793 0.227 -3 0.865
RSK2RSK2 0.793 0.099 -3 0.859
ICKICK 0.792 0.126 -3 0.900
MOSMOS 0.792 0.064 1 0.852
QIKQIK 0.791 0.253 -3 0.875
BRSK1BRSK1 0.791 0.208 -3 0.852
AURBAURB 0.791 0.160 -2 0.804
DAPK2DAPK2 0.790 0.158 -3 0.908
P90RSKP90RSK 0.790 0.092 -3 0.858
CAMLCKCAMLCK 0.790 0.138 -2 0.927
MST4MST4 0.789 0.051 2 0.635
NUAK1NUAK1 0.789 0.183 -3 0.855
PKACGPKACG 0.789 0.115 -2 0.848
SRPK1SRPK1 0.789 0.093 -3 0.839
PIM1PIM1 0.789 0.107 -3 0.856
ERK5ERK5 0.789 0.055 1 0.839
NLKNLK 0.788 0.029 1 0.793
RAF1RAF1 0.788 0.042 1 0.827
PRKD3PRKD3 0.788 0.127 -3 0.830
PRPKPRPK 0.787 -0.065 -1 0.889
TSSK2TSSK2 0.787 0.161 -5 0.861
CHAK2CHAK2 0.787 0.098 -1 0.882
NIM1NIM1 0.786 0.117 3 0.742
WNK1WNK1 0.786 0.041 -2 0.918
PKACBPKACB 0.786 0.153 -2 0.809
PKCDPKCD 0.786 0.055 2 0.571
ATRATR 0.785 0.039 1 0.812
P70S6KBP70S6KB 0.785 0.086 -3 0.867
MNK2MNK2 0.785 0.095 -2 0.890
GCN2GCN2 0.785 -0.078 2 0.560
PAK1PAK1 0.785 0.097 -2 0.895
SSTKSSTK 0.784 0.262 4 0.523
MTORMTOR 0.784 -0.039 1 0.755
NIKNIK 0.784 0.069 -3 0.902
TGFBR2TGFBR2 0.784 0.003 -2 0.798
PAK3PAK3 0.783 0.092 -2 0.883
PKN3PKN3 0.783 0.017 -3 0.879
TBK1TBK1 0.783 -0.020 1 0.720
MELKMELK 0.783 0.141 -3 0.866
PKN2PKN2 0.783 0.029 -3 0.882
MAPKAPK3MAPKAPK3 0.783 0.080 -3 0.844
PKG2PKG2 0.783 0.128 -2 0.800
NEK6NEK6 0.782 -0.022 -2 0.849
ULK2ULK2 0.782 -0.096 2 0.573
RIPK3RIPK3 0.781 -0.014 3 0.737
PRKXPRKX 0.781 0.153 -3 0.765
PDHK4PDHK4 0.781 -0.122 1 0.829
HIPK2HIPK2 0.781 0.103 1 0.572
SRPK2SRPK2 0.781 0.092 -3 0.778
CLK4CLK4 0.780 0.121 -3 0.849
RSK4RSK4 0.780 0.100 -3 0.828
KISKIS 0.780 0.048 1 0.650
LATS2LATS2 0.780 0.017 -5 0.759
HIPK1HIPK1 0.780 0.111 1 0.680
MYLK4MYLK4 0.780 0.136 -2 0.882
BMPR2BMPR2 0.779 -0.068 -2 0.878
CLK1CLK1 0.778 0.115 -3 0.834
CDK7CDK7 0.778 0.044 1 0.632
MSK2MSK2 0.778 0.081 -3 0.827
DYRK2DYRK2 0.778 0.062 1 0.662
WNK3WNK3 0.778 -0.022 1 0.804
PHKG1PHKG1 0.778 0.039 -3 0.872
HUNKHUNK 0.777 -0.010 2 0.541
AKT2AKT2 0.777 0.122 -3 0.790
PDHK1PDHK1 0.777 -0.094 1 0.813
IKKBIKKB 0.777 -0.078 -2 0.736
IRE1IRE1 0.777 -0.040 1 0.797
MNK1MNK1 0.777 0.072 -2 0.889
PKCBPKCB 0.777 0.019 2 0.529
MAPKAPK2MAPKAPK2 0.777 0.064 -3 0.813
PKCAPKCA 0.776 0.018 2 0.538
PIM2PIM2 0.776 0.119 -3 0.836
PAK2PAK2 0.776 0.093 -2 0.882
MSK1MSK1 0.776 0.101 -3 0.828
IKKEIKKE 0.776 -0.054 1 0.715
PAK6PAK6 0.776 0.082 -2 0.830
SGK3SGK3 0.776 0.104 -3 0.838
CAMK4CAMK4 0.776 0.051 -3 0.868
NEK7NEK7 0.775 -0.075 -3 0.840
CAMK1GCAMK1G 0.775 0.123 -3 0.841
CLK2CLK2 0.775 0.108 -3 0.831
CAMK2DCAMK2D 0.774 -0.033 -3 0.885
PKACAPKACA 0.774 0.145 -2 0.764
DYRK1ADYRK1A 0.774 0.093 1 0.692
PKCGPKCG 0.774 0.001 2 0.527
PKCZPKCZ 0.774 0.023 2 0.579
MLK2MLK2 0.774 -0.042 2 0.606
LATS1LATS1 0.773 0.043 -3 0.878
AURAAURA 0.773 0.109 -2 0.787
DSTYKDSTYK 0.773 -0.115 2 0.605
HIPK3HIPK3 0.772 0.086 1 0.685
MASTLMASTL 0.772 -0.092 -2 0.827
MLK1MLK1 0.772 -0.106 2 0.570
CAMK2GCAMK2G 0.772 -0.130 2 0.541
CHAK1CHAK1 0.772 0.020 2 0.649
CDK18CDK18 0.771 0.021 1 0.567
RIPK1RIPK1 0.771 -0.051 1 0.802
PKCHPKCH 0.770 -0.001 2 0.513
NEK9NEK9 0.770 -0.088 2 0.605
SNRKSNRK 0.770 0.046 2 0.491
SRPK3SRPK3 0.769 0.051 -3 0.811
IRE2IRE2 0.769 -0.038 2 0.534
BCKDKBCKDK 0.769 -0.113 -1 0.835
GSK3BGSK3B 0.768 -0.042 4 0.138
CDK8CDK8 0.768 -0.002 1 0.616
GRK1GRK1 0.768 -0.042 -2 0.797
MLK3MLK3 0.767 -0.069 2 0.533
ANKRD3ANKRD3 0.767 -0.064 1 0.841
DCAMKL1DCAMKL1 0.767 0.072 -3 0.847
AKT1AKT1 0.767 0.120 -3 0.801
PKRPKR 0.767 -0.026 1 0.835
CDK19CDK19 0.767 0.011 1 0.579
CAMK2ACAMK2A 0.767 -0.014 2 0.524
P38AP38A 0.767 0.038 1 0.690
DYRK3DYRK3 0.767 0.104 1 0.683
DYRK1BDYRK1B 0.767 0.074 1 0.617
NEK2NEK2 0.767 -0.004 2 0.612
CHK1CHK1 0.766 0.060 -3 0.864
MPSK1MPSK1 0.766 0.101 1 0.809
MAKMAK 0.766 0.142 -2 0.848
ULK1ULK1 0.766 -0.144 -3 0.808
FAM20CFAM20C 0.766 -0.038 2 0.394
CAMK2BCAMK2B 0.766 -0.044 2 0.507
GRK5GRK5 0.765 -0.149 -3 0.840
PKCTPKCT 0.765 0.028 2 0.529
IKKAIKKA 0.765 -0.058 -2 0.715
CAMK1DCAMK1D 0.764 0.117 -3 0.777
ATMATM 0.764 -0.010 1 0.744
DAPK3DAPK3 0.764 0.137 -3 0.862
PHKG2PHKG2 0.764 0.026 -3 0.856
BMPR1BBMPR1B 0.764 0.041 1 0.803
GSK3AGSK3A 0.764 -0.034 4 0.140
CDK5CDK5 0.763 -0.005 1 0.655
ALK4ALK4 0.763 -0.014 -2 0.827
P70S6KP70S6K 0.763 0.073 -3 0.803
BUB1BUB1 0.762 0.158 -5 0.798
SMMLCKSMMLCK 0.762 0.093 -3 0.882
TGFBR1TGFBR1 0.762 0.001 -2 0.794
CDK14CDK14 0.762 0.024 1 0.609
DLKDLK 0.761 -0.147 1 0.812
MOKMOK 0.761 0.131 1 0.733
PKCIPKCI 0.761 0.032 2 0.551
VRK2VRK2 0.761 -0.079 1 0.843
TTBK2TTBK2 0.761 -0.136 2 0.508
AKT3AKT3 0.760 0.120 -3 0.738
P38BP38B 0.760 0.034 1 0.613
PAK5PAK5 0.760 0.092 -2 0.779
IRAK4IRAK4 0.760 -0.028 1 0.802
WNK4WNK4 0.760 -0.014 -2 0.905
DYRK4DYRK4 0.760 0.036 1 0.581
SMG1SMG1 0.760 -0.001 1 0.767
MEK1MEK1 0.759 -0.057 2 0.600
PKCEPKCE 0.759 0.045 2 0.523
ERK1ERK1 0.759 0.012 1 0.600
CAMK1ACAMK1A 0.759 0.144 -3 0.754
DCAMKL2DCAMKL2 0.758 0.035 -3 0.869
CDK17CDK17 0.758 0.001 1 0.505
GRK6GRK6 0.758 -0.127 1 0.813
GRK7GRK7 0.758 -0.003 1 0.749
ROCK2ROCK2 0.758 0.144 -3 0.851
CDK13CDK13 0.757 -0.024 1 0.601
SGK1SGK1 0.757 0.118 -3 0.723
MRCKBMRCKB 0.757 0.128 -3 0.819
PAK4PAK4 0.757 0.083 -2 0.795
TLK2TLK2 0.757 -0.043 1 0.780
CDK1CDK1 0.756 -0.000 1 0.588
MAPKAPK5MAPKAPK5 0.756 0.003 -3 0.805
MST3MST3 0.756 -0.006 2 0.611
CDK10CDK10 0.756 0.024 1 0.594
PERKPERK 0.755 -0.065 -2 0.823
YSK4YSK4 0.755 -0.099 1 0.768
PLK1PLK1 0.755 -0.107 -2 0.795
NEK5NEK5 0.755 -0.011 1 0.832
DAPK1DAPK1 0.754 0.105 -3 0.853
CDK12CDK12 0.754 -0.015 1 0.572
DNAPKDNAPK 0.754 -0.019 1 0.680
CDK9CDK9 0.754 -0.025 1 0.610
PLK4PLK4 0.754 -0.071 2 0.427
JNK2JNK2 0.754 -0.006 1 0.572
MRCKAMRCKA 0.753 0.123 -3 0.828
CHK2CHK2 0.753 0.090 -3 0.745
PKN1PKN1 0.753 0.045 -3 0.817
GRK4GRK4 0.753 -0.155 -2 0.823
DRAK1DRAK1 0.753 -0.058 1 0.772
MLK4MLK4 0.752 -0.127 2 0.514
ACVR2BACVR2B 0.752 -0.004 -2 0.781
ACVR2AACVR2A 0.752 -0.023 -2 0.773
CDK16CDK16 0.752 0.002 1 0.524
HRIHRI 0.752 -0.083 -2 0.838
LKB1LKB1 0.752 0.095 -3 0.831
ERK2ERK2 0.751 -0.024 1 0.638
P38GP38G 0.751 -0.001 1 0.502
PKG1PKG1 0.751 0.120 -2 0.724
MEKK1MEKK1 0.750 -0.082 1 0.790
MEK5MEK5 0.750 -0.121 2 0.598
PBKPBK 0.750 0.121 1 0.827
ERK7ERK7 0.750 -0.003 2 0.413
DMPK1DMPK1 0.750 0.154 -3 0.837
CDK2CDK2 0.749 -0.028 1 0.672
ALK2ALK2 0.749 -0.047 -2 0.804
PASKPASK 0.749 -0.001 -3 0.892
TAO3TAO3 0.749 -0.016 1 0.789
PRP4PRP4 0.749 -0.006 -3 0.761
MEKK2MEKK2 0.748 -0.085 2 0.575
JNK3JNK3 0.747 -0.027 1 0.603
PINK1PINK1 0.747 -0.058 1 0.802
CDK3CDK3 0.747 0.003 1 0.527
PLK3PLK3 0.747 -0.086 2 0.510
MEKK6MEKK6 0.746 -0.021 1 0.803
TLK1TLK1 0.746 -0.063 -2 0.811
GAKGAK 0.745 0.034 1 0.872
ZAKZAK 0.745 -0.139 1 0.752
BRAFBRAF 0.745 -0.090 -4 0.814
ROCK1ROCK1 0.745 0.133 -3 0.828
NEK4NEK4 0.745 0.008 1 0.796
CRIKCRIK 0.745 0.136 -3 0.803
CK1ECK1E 0.744 -0.033 -3 0.530
P38DP38D 0.744 0.013 1 0.524
BMPR1ABMPR1A 0.744 0.004 1 0.770
GRK2GRK2 0.744 -0.054 -2 0.715
SBKSBK 0.743 0.092 -3 0.692
NEK11NEK11 0.743 -0.078 1 0.767
PDK1PDK1 0.743 0.002 1 0.763
NEK8NEK8 0.743 -0.065 2 0.592
LOKLOK 0.742 0.024 -2 0.795
GCKGCK 0.742 0.021 1 0.805
TAO2TAO2 0.742 -0.053 2 0.618
MAP3K15MAP3K15 0.742 -0.020 1 0.744
NEK1NEK1 0.741 0.030 1 0.804
IRAK1IRAK1 0.740 -0.107 -1 0.790
MEKK3MEKK3 0.740 -0.168 1 0.802
TNIKTNIK 0.740 -0.004 3 0.814
CAMKK2CAMKK2 0.740 -0.019 -2 0.751
HPK1HPK1 0.739 0.024 1 0.787
HGKHGK 0.739 -0.017 3 0.810
MINKMINK 0.739 -0.015 1 0.794
KHS1KHS1 0.738 0.036 1 0.778
TTBK1TTBK1 0.737 -0.116 2 0.452
LRRK2LRRK2 0.736 -0.048 2 0.615
KHS2KHS2 0.736 0.031 1 0.791
CAMKK1CAMKK1 0.735 -0.107 -2 0.743
CDK6CDK6 0.735 -0.023 1 0.589
CK1G1CK1G1 0.734 -0.059 -3 0.506
MST2MST2 0.734 -0.063 1 0.808
CK1DCK1D 0.734 -0.023 -3 0.474
CDK4CDK4 0.734 -0.024 1 0.558
VRK1VRK1 0.733 -0.063 2 0.573
CK1A2CK1A2 0.733 -0.026 -3 0.480
YSK1YSK1 0.732 -0.047 2 0.600
NEK3NEK3 0.731 -0.040 1 0.755
EEF2KEEF2K 0.731 -0.097 3 0.759
MEK2MEK2 0.730 -0.080 2 0.589
STK33STK33 0.730 -0.093 2 0.457
SLKSLK 0.730 -0.023 -2 0.730
MST1MST1 0.729 -0.047 1 0.793
TAK1TAK1 0.728 -0.073 1 0.804
GRK3GRK3 0.727 -0.069 -2 0.673
TTKTTK 0.725 -0.022 -2 0.820
MYO3BMYO3B 0.725 -0.005 2 0.629
JNK1JNK1 0.725 -0.039 1 0.554
CK2A2CK2A2 0.724 -0.045 1 0.730
YANK3YANK3 0.724 -0.043 2 0.297
HASPINHASPIN 0.724 0.006 -1 0.764
RIPK2RIPK2 0.724 -0.131 1 0.717
BIKEBIKE 0.722 0.048 1 0.771
PDHK3_TYRPDHK3_TYR 0.721 0.102 4 0.324
PLK2PLK2 0.721 -0.069 -3 0.779
LIMK2_TYRLIMK2_TYR 0.720 0.119 -3 0.900
TAO1TAO1 0.719 -0.044 1 0.714
OSR1OSR1 0.717 -0.077 2 0.603
TESK1_TYRTESK1_TYR 0.716 0.043 3 0.843
CK2A1CK2A1 0.716 -0.059 1 0.714
PKMYT1_TYRPKMYT1_TYR 0.715 0.046 3 0.828
MYO3AMYO3A 0.714 -0.048 1 0.770
MAP2K4_TYRMAP2K4_TYR 0.711 0.003 -1 0.902
ASK1ASK1 0.711 -0.081 1 0.721
AAK1AAK1 0.711 0.072 1 0.684
PDHK4_TYRPDHK4_TYR 0.711 0.019 2 0.634
MAP2K7_TYRMAP2K7_TYR 0.709 -0.038 2 0.612
LIMK1_TYRLIMK1_TYR 0.708 -0.005 2 0.628
TNK2TNK2 0.708 0.044 3 0.760
ABL2ABL2 0.707 0.037 -1 0.822
ROS1ROS1 0.706 -0.000 3 0.757
MAP2K6_TYRMAP2K6_TYR 0.706 -0.081 -1 0.899
ABL1ABL1 0.705 0.039 -1 0.818
TNNI3K_TYRTNNI3K_TYR 0.705 0.049 1 0.799
RETRET 0.704 -0.037 1 0.787
TNK1TNK1 0.704 0.037 3 0.764
PINK1_TYRPINK1_TYR 0.704 -0.110 1 0.821
TYK2TYK2 0.703 -0.036 1 0.785
EPHA6EPHA6 0.703 -0.030 -1 0.850
MST1RMST1R 0.703 -0.032 3 0.800
TYRO3TYRO3 0.702 -0.048 3 0.775
DDR1DDR1 0.702 -0.052 4 0.307
EPHB4EPHB4 0.702 -0.028 -1 0.833
PDHK1_TYRPDHK1_TYR 0.701 -0.071 -1 0.897
BMPR2_TYRBMPR2_TYR 0.701 -0.073 -1 0.872
CK1ACK1A 0.701 -0.041 -3 0.378
JAK1JAK1 0.700 0.052 1 0.724
FGRFGR 0.700 -0.017 1 0.881
JAK2JAK2 0.700 -0.041 1 0.776
NEK10_TYRNEK10_TYR 0.699 0.044 1 0.671
BLKBLK 0.698 0.064 -1 0.827
LCKLCK 0.698 0.035 -1 0.823
TXKTXK 0.698 0.017 1 0.858
CSF1RCSF1R 0.696 -0.060 3 0.781
YES1YES1 0.696 -0.038 -1 0.860
STLK3STLK3 0.696 -0.120 1 0.733
ALPHAK3ALPHAK3 0.696 -0.110 -1 0.784
DDR2DDR2 0.694 0.006 3 0.720
HCKHCK 0.693 -0.027 -1 0.826
PDGFRBPDGFRB 0.693 -0.076 3 0.787
FERFER 0.692 -0.072 1 0.860
JAK3JAK3 0.691 -0.076 1 0.763
AXLAXL 0.691 -0.055 3 0.762
ALKALK 0.689 -0.036 3 0.712
INSRRINSRR 0.689 -0.084 3 0.724
ITKITK 0.688 -0.069 -1 0.802
EPHB1EPHB1 0.688 -0.071 1 0.836
EPHA4EPHA4 0.688 -0.076 2 0.518
EPHB3EPHB3 0.688 -0.069 -1 0.813
LTKLTK 0.687 -0.051 3 0.738
KDRKDR 0.687 -0.073 3 0.745
SRMSSRMS 0.687 -0.090 1 0.845
MERTKMERTK 0.687 -0.059 3 0.761
PDGFRAPDGFRA 0.686 -0.105 3 0.787
EPHB2EPHB2 0.685 -0.068 -1 0.804
METMET 0.684 -0.071 3 0.781
YANK2YANK2 0.684 -0.074 2 0.306
FLT3FLT3 0.684 -0.116 3 0.766
EPHA1EPHA1 0.684 -0.063 3 0.758
FGFR2FGFR2 0.684 -0.121 3 0.767
PTK2BPTK2B 0.683 -0.022 -1 0.793
TECTEC 0.683 -0.059 -1 0.748
FGFR1FGFR1 0.683 -0.079 3 0.746
TEKTEK 0.683 -0.097 3 0.714
BTKBTK 0.682 -0.105 -1 0.777
KITKIT 0.682 -0.108 3 0.776
BMXBMX 0.681 -0.050 -1 0.721
WEE1_TYRWEE1_TYR 0.680 -0.090 -1 0.774
PTK6PTK6 0.680 -0.092 -1 0.745
EPHA7EPHA7 0.680 -0.082 2 0.529
INSRINSR 0.679 -0.090 3 0.707
FYNFYN 0.679 -0.032 -1 0.798
LYNLYN 0.677 -0.056 3 0.701
EPHA3EPHA3 0.676 -0.115 2 0.503
NTRK1NTRK1 0.676 -0.144 -1 0.830
FRKFRK 0.675 -0.091 -1 0.826
NTRK2NTRK2 0.675 -0.117 3 0.735
NTRK3NTRK3 0.672 -0.099 -1 0.780
SRCSRC 0.671 -0.061 -1 0.804
ERBB2ERBB2 0.670 -0.141 1 0.735
MATKMATK 0.669 -0.085 -1 0.748
FGFR3FGFR3 0.669 -0.135 3 0.739
FLT4FLT4 0.668 -0.153 3 0.733
EPHA5EPHA5 0.667 -0.115 2 0.497
EPHA8EPHA8 0.666 -0.094 -1 0.784
CK1G3CK1G3 0.666 -0.078 -3 0.327
FLT1FLT1 0.666 -0.148 -1 0.815
PTK2PTK2 0.666 -0.043 -1 0.760
CSKCSK 0.663 -0.125 2 0.530
MUSKMUSK 0.661 -0.093 1 0.650
IGF1RIGF1R 0.657 -0.124 3 0.645
EGFREGFR 0.657 -0.114 1 0.639
FGFR4FGFR4 0.655 -0.118 -1 0.768
EPHA2EPHA2 0.655 -0.114 -1 0.748
SYKSYK 0.652 -0.083 -1 0.746
CK1G2CK1G2 0.650 -0.078 -3 0.422
FESFES 0.647 -0.098 -1 0.705
ERBB4ERBB4 0.646 -0.098 1 0.659
ZAP70ZAP70 0.635 -0.064 -1 0.686