Motif 212 (n=183)

Position-wise Probabilities
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uniprot genes site source protein function
A1A5D9 BICDL2 S330 ochoa BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) None
A6NDB9 PALM3 S124 ochoa Paralemmin-3 ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}.
A6NJU9 NPIPB13 S1099 ochoa Nuclear pore complex-interacting protein family member B13 None
A8MRT5 NPIPB5 S1065 ochoa Nuclear pore complex-interacting protein family member B5 None
C9JG80 NPIPB4 S1070 ochoa Nuclear pore complex-interacting protein family member B4 None
E5RHQ5 NPIPB11 S1122 ochoa Nuclear pore complex-interacting protein family member B11 None
O00506 STK25 S231 ochoa Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}.
O14939 PLD2 S146 psp Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}.
O14981 BTAF1 S91 ochoa TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.
O15258 RER1 S100 ochoa Protein RER1 Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. {ECO:0000250}.
O43303 CCP110 S337 ochoa Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.
O43303 CCP110 S384 ochoa Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.
O43426 SYNJ1 S1391 ochoa Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}.
O43896 KIF1C S983 ochoa Kinesin-like protein KIF1C Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}.
O60333 KIF1B S1468 ochoa Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}.
O75363 BCAS1 S115 ochoa Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}.
O75385 ULK1 S556 ochoa|psp Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75385 ULK1 S588 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75815 BCAR3 S269 ochoa Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.
O76024 WFS1 S32 ochoa Wolframin Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048). {ECO:0000269|PubMed:16989814, ECO:0000269|PubMed:23035048}.
O94761 RECQL4 S325 ochoa ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269|PubMed:15317757, ECO:0000269|PubMed:22730300, ECO:0000269|PubMed:28653661}.
O95180 CACNA1H S1099 ochoa Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.
O95466 FMNL1 S1044 ochoa Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
O95613 PCNT S2433 ochoa Pericentrin (Kendrin) (Pericentrin-B) Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}.
O95639 CPSF4 S230 ochoa Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}.
O95685 PPP1R3D S77 ochoa Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.
O95835 LATS1 S1107 ochoa Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}.
O95866 MPIG6B S208 ochoa Megakaryocyte and platelet inhibitory receptor G6b (Protein G6b) Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). {ECO:0000269|PubMed:12665801, ECO:0000269|PubMed:17311996, ECO:0000269|PubMed:27743390}.; FUNCTION: Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. {ECO:0000305|PubMed:11544253}.
P00519 ABL1 S828 ochoa Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P05023 ATP1A1 S668 ochoa Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}.
P06213 INSR S1216 psp Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.
P06400 RB1 S794 ochoa Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.
P07359 GP1BA S632 ochoa|psp Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin] GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
P07451 CA3 S100 ochoa Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}.
P10070 GLI2 S135 ochoa Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}.
P10636 MAPT S171 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11137 MAP2 S1640 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P13498 CYBA S153 ochoa|psp Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103, PubMed:17140397, PubMed:38355798). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:19948736). Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (PubMed:15824103, PubMed:17140397). {ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17140397, ECO:0000269|PubMed:19948736, ECO:0000269|PubMed:38355798}.
P20810 CAST S236 ochoa Calpastatin (Calpain inhibitor) (Sperm BS-17 component) Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P26358 DNMT1 T166 ochoa DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}.
P28290 ITPRID2 S1152 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P30260 CDC27 S192 ochoa Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P38159 RBMX S165 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P41145 OPRK1 S358 psp Kappa-type opioid receptor (K-OR-1) (KOR-1) G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.
P43403 ZAP70 S106 ochoa Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}.
P46013 MKI67 S2686 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P49450 CENPA S37 ochoa Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.
P51587 BRCA2 S76 ochoa|psp Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P51957 NEK4 S665 ochoa Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
P52179 MYOM1 S618 psp Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
P56945 BCAR1 S407 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P82094 TMF1 S136 ochoa TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}.
Q01780 EXOSC10 S217 ochoa Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}.
Q02218 OGDH S870 ochoa 2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050, PubMed:35272141). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). {ECO:0000269|PubMed:24495017, ECO:0000269|PubMed:25210035, ECO:0000269|PubMed:28435050, ECO:0000269|PubMed:29211711, ECO:0000303|PubMed:25210035}.
Q04721 NOTCH2 S2388 ochoa Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}.
Q07157 TJP1 S1196 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q10586 DBP S165 ochoa D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Q12789 GTF3C1 S1868 ochoa General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Q13191 CBLB S856 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13459 MYO9B S2049 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q13946 PDE7A S28 ochoa High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) (cAMP-specific phosphodiesterase 7A) Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912). {ECO:0000269|PubMed:19350606, ECO:0000269|PubMed:8389765, ECO:0000269|PubMed:9195912}.
Q13950 RUNX2 S347 psp Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.
Q13950 RUNX2 S388 psp Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}.
Q14157 UBAP2L S859 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14517 FAT1 S4476 ochoa Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.
Q14526 HIC1 S304 ochoa Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}.
Q14699 RFTN1 S238 ochoa Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.
Q15648 MED1 S770 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15648 MED1 S772 ochoa Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15751 HERC1 S2706 ochoa Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
Q16825 PTPN21 S538 ochoa Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) None
Q2M3V2 SOWAHA S264 ochoa Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) None
Q2TAL8 QRICH1 S240 ochoa Transcriptional regulator QRICH1 (Glutamine-rich protein 1) Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}.
Q2TAZ0 ATG2A S866 ochoa Autophagy-related protein 2 homolog A Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
Q58A45 PAN3 S368 ochoa PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.
Q5JTV8 TOR1AIP1 S60 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5SYE7 NHSL1 S328 ochoa NHS-like protein 1 None
Q5T6F2 UBAP2 S946 ochoa Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}.
Q5T8P6 RBM26 S487 ochoa RNA-binding protein 26 (CTCL tumor antigen se70-2) (RNA-binding motif protein 26) May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}.
Q5TEJ8 THEMIS2 S606 ochoa Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2) May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0, ECO:0000269|PubMed:20644716}.
Q5VT52 RPRD2 S491 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q658P3 STEAP3 S19 ochoa Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}.
Q68CZ2 TNS3 S1292 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6IAA8 LAMTOR1 S55 ochoa Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.
Q6KC79 NIPBL S305 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NTF9 RHBDD2 S266 ochoa Rhomboid domain-containing protein 2 None
Q6P0N0 MIS18BP1 S365 ochoa Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.
Q6PJI9 WDR59 S834 ochoa GATOR2 complex protein WDR59 (WD repeat-containing protein 59) As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027, ECO:0000269|PubMed:36577058}.
Q6ZMT1 STAC2 S112 ochoa SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}.
Q6ZNJ1 NBEAL2 S1836 ochoa Neurobeachin-like protein 2 Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.
Q7KZ85 SUPT6H S1535 ochoa Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. {ECO:0000269|PubMed:15060154, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:22316138, ECO:0000269|PubMed:23503590, ECO:0000269|PubMed:9514752}.
Q7L4E1 MIGA2 S220 ochoa Mitoguardin 2 (Protein FAM73B) Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}.
Q7RTP6 MICAL3 S1290 ochoa [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}.
Q7Z3B3 KANSL1 S1021 ochoa KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}.
Q7Z5J4 RAI1 S1064 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q7Z6Z7 HUWE1 S2931 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86TC9 MYPN S1051 ochoa Myopalladin (145 kDa sarcomeric protein) Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}.
Q86VI3 IQGAP3 S1429 ochoa Ras GTPase-activating-like protein IQGAP3 None
Q86X10 RALGAPB S1022 ochoa Ral GTPase-activating protein subunit beta (p170) Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q8IWR0 ZC3H7A S780 ochoa Zinc finger CCCH domain-containing protein 7A May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.
Q8IX21 SLF2 S653 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IY92 SLX4 S1452 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IYD8 FANCM S52 ochoa Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8N350 CBARP S503 ochoa Voltage-dependent calcium channel beta subunit-associated regulatory protein Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}.
Q8N3K9 CMYA5 S2854 ochoa Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}.
Q8N4C8 MINK1 S641 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N884 CGAS S64 ochoa Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}.
Q8NAX2 KDF1 S208 ochoa Keratinocyte differentiation factor 1 Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}.
Q8NBV4 PLPP7 S46 ochoa Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}.
Q8ND83 SLAIN1 S403 ochoa SLAIN motif-containing protein 1 Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269|PubMed:21646404}.
Q8NFC6 BOD1L1 S1989 ochoa Biorientation of chromosomes in cell division protein 1-like 1 Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}.
Q8NFH8 REPS2 S218 ochoa RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}.
Q8NG48 LINS1 S591 ochoa Protein Lines homolog 1 (Wnt-signaling molecule Lines homolog 1) None
Q8TDM6 DLG5 Y1077 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TEQ0 SNX29 S444 ochoa Sorting nexin-29 (RUN domain-containing protein 2A) None
Q8TEW0 PARD3 S924 ochoa Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}.
Q8TEW8 PARD3B S780 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUX9 CHMP7 S410 ochoa Charged multivesicular body protein 7 (Chromatin-modifying protein 7) ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
Q8WY36 BBX S177 ochoa HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.
Q92617 NPIPB3 S982 ochoa Nuclear pore complex-interacting protein family member B3 (Nuclear pore complex-interacting protein-like 3) (Protein pps22-1) None
Q92766 RREB1 S522 ochoa Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.
Q969G9 NKD1 S317 ochoa Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.
Q969W3 VCF1 S144 ochoa Protein VCF1 (VCP nuclear cofactor family member 1) None
Q96AY4 TTC28 S28 ochoa Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}.
Q96E09 PABIR1 S189 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96EY5 MVB12A S170 ochoa|psp Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.
Q96ID5 IGSF21 S389 ochoa Immunoglobulin superfamily member 21 (IgSF21) Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. {ECO:0000250|UniProtKB:Q7TNR6}.
Q96JK2 DCAF5 S496 ochoa DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}.
Q96PE2 ARHGEF17 S1002 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96PE2 ARHGEF17 S2005 ochoa Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}.
Q96SB4 SRPK1 S333 ochoa SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}.
Q99081 TCF12 S163 ochoa Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). {ECO:0000250|UniProtKB:Q61286, ECO:0000269|PubMed:32620954}.
Q99550 MPHOSPH9 S1006 ochoa M-phase phosphoprotein 9 Negatively regulates cilia formation by recruiting the CP110-CEP97 complex (a negative regulator of ciliogenesis) at the distal end of the mother centriole in ciliary cells (PubMed:30375385). At the beginning of cilia formation, MPHOSPH9 undergoes TTBK2-mediated phosphorylation and degradation via the ubiquitin-proteasome system and removes itself and the CP110-CEP97 complex from the distal end of the mother centriole, which subsequently promotes cilia formation (PubMed:30375385). {ECO:0000269|PubMed:30375385}.
Q99569 PKP4 S1153 ochoa Plakophilin-4 (p0071) Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}.
Q99640 PKMYT1 S473 ochoa Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
Q99755 PIP5K1A S71 ochoa Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:21477596, PubMed:22942276, PubMed:8955136). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (PubMed:19158393, PubMed:20660631). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro (PubMed:22942276). Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation (PubMed:19158393). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane (PubMed:20660631). Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197). {ECO:0000250|UniProtKB:P70182, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:19158393, ECO:0000269|PubMed:20660631, ECO:0000269|PubMed:21477596, ECO:0000269|PubMed:22942276, ECO:0000269|PubMed:8955136}.
Q9BRD0 BUD13 S175 ochoa BUD13 homolog Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}.
Q9BVT8 TMUB1 S113 ochoa Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}.
Q9BW04 SARG S281 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BW71 HIRIP3 S100 ochoa HIRA-interacting protein 3 Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}.
Q9H0W5 CCDC8 S273 ochoa Coiled-coil domain-containing protein 8 Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). {ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}.
Q9H1B7 IRF2BPL S219 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H4L5 OSBPL3 S309 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H7E2 TDRD3 S345 ochoa Tudor domain-containing protein 3 Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}.
Q9H910 JPT2 S75 ochoa Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}.
Q9NSY1 BMP2K S1111 ochoa BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.
Q9NUL3 STAU2 S93 ochoa Double-stranded RNA-binding protein Staufen homolog 2 RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}.
Q9P0V3 SH3BP4 S122 ochoa SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
Q9P206 NHSL3 S314 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P242 NYAP2 S154 ochoa Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P244 LRFN1 S731 ochoa Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}.
Q9UBY5 LPAR3 S331 ochoa Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Q9UEE9 CFDP1 S221 ochoa Craniofacial development protein 1 (Bucentaur) May play a role during embryogenesis. {ECO:0000250}.
Q9UHD8 SEPTIN9 S247 ochoa Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}.
Q9UHI6 DDX20 S47 ochoa Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
Q9UHY8 FEZ2 S65 ochoa Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) Involved in axonal outgrowth and fasciculation. {ECO:0000250}.
Q9UJY1 HSPB8 S24 ochoa|psp Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|UniProtKB:Q9JK92}.
Q9UKD1 GMEB2 S366 ochoa Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Q9UKE5 TNIK S659 ochoa TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
Q9ULH7 MRTFB S395 ochoa Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}.
Q9UQC2 GAB2 S404 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y2B5 VPS9D1 S116 ochoa VPS9 domain-containing protein 1 (Protein ATP-BL) None
Q9Y2K7 KDM2A S562 ochoa Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.
Q9Y3S1 WNK2 S49 ochoa Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}.
Q9Y4H2 IRS2 S805 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y520 PRRC2C S834 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
Q9Y6X6 MYO16 S1362 ochoa Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.
P00491 PNP S163 Sugiyama Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:9305964). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964). {ECO:0000269|PubMed:23438750, ECO:0000269|PubMed:9305964}.
P29401 TKT S305 Sugiyama Transketolase (TK) (EC 2.2.1.1) Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}.
Q9H4F8 SMOC1 S65 Sugiyama SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. {ECO:0000269|PubMed:20359165, ECO:0000269|PubMed:21194678, ECO:0000269|PubMed:21194680}.
P46060 RANGAP1 S454 Sugiyama Ran GTPase-activating protein 1 (RanGAP1) GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}.
Q92888 ARHGEF1 S545 Sugiyama Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}.
Q14204 DYNC1H1 S4162 Sugiyama Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.
Q8NAF0 ZNF579 S455 Sugiyama Zinc finger protein 579 May be involved in transcriptional regulation.
Q08289 CACNB2 S483 EPSD Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}.
Q9NZQ3 NCKIPSD S256 Sugiyama NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.
Q12959 DLG1 S733 Sugiyama Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.
Q15700 DLG2 S699 Sugiyama Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
P30305 CDC25B S219 SIGNOR M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P00966 ASS1 S189 Sugiyama Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}.
Q16512 PKN1 S296 Sugiyama Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.
Q96PE3 INPP4A S788 Sugiyama Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity) (PubMed:30071275). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). {ECO:0000250|UniProtKB:Q62784, ECO:0000250|UniProtKB:Q9EPW0, ECO:0000269|PubMed:15716355, ECO:0000269|PubMed:20463662, ECO:0000269|PubMed:30071275}.; FUNCTION: [Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3. {ECO:0000269|PubMed:9295334}.
Q9Y4K4 MAP4K5 S413 Sugiyama Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
Download
reactome_id name p -log10_p
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.000110 3.957
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.000096 4.016
R-HSA-8941326 RUNX2 regulates bone development 0.000256 3.591
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.001032 2.986
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.002787 2.555
R-HSA-74713 IRS activation 0.003762 2.425
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.005254 2.280
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.005254 2.280
R-HSA-8849932 Synaptic adhesion-like molecules 0.003371 2.472
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.004872 2.312
R-HSA-447038 NrCAM interactions 0.003762 2.425
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.005254 2.280
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.004590 2.338
R-HSA-9700206 Signaling by ALK in cancer 0.004590 2.338
R-HSA-8878166 Transcriptional regulation by RUNX2 0.007736 2.111
R-HSA-9620244 Long-term potentiation 0.007662 2.116
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.008983 2.047
R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus 0.012712 1.896
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.012339 1.909
R-HSA-8941332 RUNX2 regulates genes involved in cell migration 0.014192 1.848
R-HSA-9615710 Late endosomal microautophagy 0.010626 1.974
R-HSA-74749 Signal attenuation 0.012339 1.909
R-HSA-451306 Ionotropic activity of kainate receptors 0.014192 1.848
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.014168 1.849
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.014168 1.849
R-HSA-8878171 Transcriptional regulation by RUNX1 0.014638 1.835
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.016157 1.792
R-HSA-69278 Cell Cycle, Mitotic 0.019647 1.707
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.025262 1.598
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.025262 1.598
R-HSA-9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 0.073897 1.131
R-HSA-9735786 Nucleotide catabolism defects 0.073897 1.131
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.073897 1.131
R-HSA-5083630 Defective LFNG causes SCDO3 0.073897 1.131
R-HSA-9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen 0.085674 1.067
R-HSA-9846298 Defective binding of VWF variant to GPIb:IX:V 0.085674 1.067
R-HSA-9673221 Defective F9 activation 0.085674 1.067
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.097301 1.012
R-HSA-9027283 Erythropoietin activates STAT5 0.108782 0.963
R-HSA-9645135 STAT5 Activation 0.108782 0.963
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.027557 1.560
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.120117 0.920
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.120117 0.920
R-HSA-112412 SOS-mediated signalling 0.120117 0.920
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.153268 0.815
R-HSA-112308 Presynaptic depolarization and calcium channel opening 0.164040 0.785
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.185177 0.732
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.185177 0.732
R-HSA-9853506 OGDH complex synthesizes succinyl-CoA from 2-OG 0.195545 0.709
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.195545 0.709
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.195545 0.709
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.074620 1.127
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.078306 1.106
R-HSA-69166 Removal of the Flap Intermediate 0.205781 0.687
R-HSA-9027284 Erythropoietin activates RAS 0.215888 0.666
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.215888 0.666
R-HSA-176412 Phosphorylation of the APC/C 0.225867 0.646
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.235720 0.628
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.245448 0.610
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.245448 0.610
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.059650 1.224
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.255052 0.593
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.063825 1.195
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.063825 1.195
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.264535 0.578
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.264535 0.578
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.264535 0.578
R-HSA-8854518 AURKA Activation by TPX2 0.070333 1.153
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.273898 0.562
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.273898 0.562
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.273898 0.562
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.273898 0.562
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.283142 0.548
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.148015 0.830
R-HSA-774815 Nucleosome assembly 0.148015 0.830
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.086616 1.062
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.292269 0.534
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.292269 0.534
R-HSA-380287 Centrosome maturation 0.091537 1.038
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.318962 0.496
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.184013 0.735
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.327635 0.485
R-HSA-141424 Amplification of signal from the kinetochores 0.120549 0.919
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.120549 0.919
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.128986 0.889
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.344653 0.463
R-HSA-9006335 Signaling by Erythropoietin 0.361242 0.442
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.361242 0.442
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.283142 0.548
R-HSA-9639288 Amino acids regulate mTORC1 0.044316 1.353
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.134724 0.871
R-HSA-9646399 Aggrephagy 0.122122 0.913
R-HSA-69183 Processive synthesis on the lagging strand 0.215888 0.666
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.266716 0.574
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.266716 0.574
R-HSA-198203 PI3K/AKT activation 0.153268 0.815
R-HSA-6783310 Fanconi Anemia Pathway 0.148015 0.830
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.301280 0.521
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.266716 0.574
R-HSA-191650 Regulation of gap junction activity 0.073897 1.131
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.097301 1.012
R-HSA-73863 RNA Polymerase I Transcription Termination 0.344653 0.463
R-HSA-453276 Regulation of mitotic cell cycle 0.268156 0.572
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.268156 0.572
R-HSA-69618 Mitotic Spindle Checkpoint 0.055374 1.257
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.072567 1.139
R-HSA-5693537 Resolution of D-Loop Structures 0.093588 1.029
R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 0.120117 0.920
R-HSA-430116 GP1b-IX-V activation signalling 0.142358 0.847
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.174676 0.758
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.089690 1.047
R-HSA-5576893 Phase 2 - plateau phase 0.235720 0.628
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.245448 0.610
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.353001 0.452
R-HSA-69186 Lagging Strand Synthesis 0.283142 0.548
R-HSA-2467813 Separation of Sister Chromatids 0.205636 0.687
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.369379 0.433
R-HSA-9675126 Diseases of mitotic cell cycle 0.085843 1.066
R-HSA-9930044 Nuclear RNA decay 0.089690 1.047
R-HSA-74752 Signaling by Insulin receptor 0.143494 0.843
R-HSA-427413 NoRC negatively regulates rRNA expression 0.268156 0.572
R-HSA-74751 Insulin receptor signalling cascade 0.065962 1.181
R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 0.037654 1.424
R-HSA-8875513 MET interacts with TNS proteins 0.061970 1.208
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.073897 1.131
R-HSA-69478 G2/M DNA replication checkpoint 0.108782 0.963
R-HSA-2470946 Cohesin Loading onto Chromatin 0.120117 0.920
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.195545 0.709
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.195545 0.709
R-HSA-162588 Budding and maturation of HIV virion 0.082047 1.086
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.235720 0.628
R-HSA-113510 E2F mediated regulation of DNA replication 0.264535 0.578
R-HSA-350054 Notch-HLH transcription pathway 0.301280 0.521
R-HSA-912526 Interleukin receptor SHC signaling 0.310178 0.508
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.318962 0.496
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.318962 0.496
R-HSA-77387 Insulin receptor recycling 0.353001 0.452
R-HSA-5576892 Phase 0 - rapid depolarisation 0.353001 0.452
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.071486 1.146
R-HSA-2428928 IRS-related events triggered by IGF1R 0.221098 0.655
R-HSA-9613829 Chaperone Mediated Autophagy 0.255052 0.593
R-HSA-6794361 Neurexins and neuroligins 0.179442 0.746
R-HSA-112399 IRS-mediated signalling 0.202457 0.694
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.344234 0.463
R-HSA-68882 Mitotic Anaphase 0.186718 0.729
R-HSA-525793 Myogenesis 0.063920 1.194
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.100382 0.998
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.188892 0.724
R-HSA-9823587 Defects of platelet adhesion to exposed collagen 0.097301 1.012
R-HSA-9735804 Diseases of nucleotide metabolism 0.195545 0.709
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.205781 0.687
R-HSA-6794362 Protein-protein interactions at synapses 0.032436 1.489
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.079698 1.099
R-HSA-212165 Epigenetic regulation of gene expression 0.152708 0.816
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.318962 0.496
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.310514 0.508
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.255052 0.593
R-HSA-2428924 IGF1R signaling cascade 0.235170 0.629
R-HSA-5693538 Homology Directed Repair 0.090694 1.042
R-HSA-73886 Chromosome Maintenance 0.249615 0.603
R-HSA-9612973 Autophagy 0.025426 1.595
R-HSA-2028269 Signaling by Hippo 0.032797 1.484
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.153268 0.815
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.070993 1.149
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.235720 0.628
R-HSA-6783984 Glycine degradation 0.235720 0.628
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.061721 1.210
R-HSA-9821993 Replacement of protamines by nucleosomes in the male pronucleus 0.318962 0.496
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.115043 0.939
R-HSA-420029 Tight junction interactions 0.327635 0.485
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.310514 0.508
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.329200 0.483
R-HSA-68877 Mitotic Prometaphase 0.137606 0.861
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.336198 0.473
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.239873 0.620
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.249615 0.603
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.025630 1.591
R-HSA-1632852 Macroautophagy 0.053691 1.270
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.116829 0.932
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.329098 0.483
R-HSA-8934903 Receptor Mediated Mitophagy 0.153268 0.815
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.235720 0.628
R-HSA-5334118 DNA methylation 0.361242 0.442
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.369379 0.433
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.058348 1.234
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.215998 0.666
R-HSA-9663891 Selective autophagy 0.128986 0.889
R-HSA-68886 M Phase 0.076142 1.118
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.325619 0.487
R-HSA-9664417 Leishmania phagocytosis 0.325619 0.487
R-HSA-9664407 Parasite infection 0.325619 0.487
R-HSA-9668250 Defective factor IX causes hemophilia B 0.153268 0.815
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.174676 0.758
R-HSA-69109 Leading Strand Synthesis 0.185177 0.732
R-HSA-69091 Polymerase switching 0.185177 0.732
R-HSA-1475029 Reversible hydration of carbon dioxide 0.195545 0.709
R-HSA-166208 mTORC1-mediated signalling 0.301280 0.521
R-HSA-429947 Deadenylation of mRNA 0.318962 0.496
R-HSA-9839394 TGFBR3 expression 0.327635 0.485
R-HSA-69275 G2/M Transition 0.049566 1.305
R-HSA-69231 Cyclin D associated events in G1 0.143623 0.843
R-HSA-69236 G1 Phase 0.143623 0.843
R-HSA-1640170 Cell Cycle 0.048881 1.311
R-HSA-453274 Mitotic G2-G2/M phases 0.051484 1.288
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 0.225867 0.646
R-HSA-9664420 Killing mechanisms 0.225867 0.646
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.336198 0.473
R-HSA-5656169 Termination of translesion DNA synthesis 0.361242 0.442
R-HSA-8856688 Golgi-to-ER retrograde transport 0.294339 0.531
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.063920 1.194
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.345519 0.462
R-HSA-8853659 RET signaling 0.105563 0.976
R-HSA-419408 Lysosphingolipid and LPA receptors 0.215888 0.666
R-HSA-1483148 Synthesis of PG 0.235720 0.628
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.117924 0.928
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.336198 0.473
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.202835 0.693
R-HSA-416482 G alpha (12/13) signalling events 0.301130 0.521
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.235129 0.629
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.215888 0.666
R-HSA-69242 S Phase 0.164965 0.783
R-HSA-438064 Post NMDA receptor activation events 0.035779 1.446
R-HSA-5693532 DNA Double-Strand Break Repair 0.177350 0.751
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.283142 0.548
R-HSA-109704 PI3K Cascade 0.170354 0.769
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.327635 0.485
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.336198 0.473
R-HSA-73894 DNA Repair 0.359401 0.444
R-HSA-199991 Membrane Trafficking 0.239645 0.620
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.126356 0.898
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.254006 0.595
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.148015 0.830
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.308109 0.511
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.153268 0.815
R-HSA-193648 NRAGE signals death through JNK 0.197825 0.704
R-HSA-983189 Kinesins 0.216423 0.665
R-HSA-8863678 Neurodegenerative Diseases 0.057106 1.243
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.057106 1.243
R-HSA-1483255 PI Metabolism 0.177136 0.752
R-HSA-9671793 Diseases of hemostasis 0.264535 0.578
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.120117 0.920
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.067425 1.171
R-HSA-75892 Platelet Adhesion to exposed collagen 0.195545 0.709
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.195545 0.709
R-HSA-175474 Assembly Of The HIV Virion 0.292269 0.534
R-HSA-70635 Urea cycle 0.336198 0.473
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.067425 1.171
R-HSA-8983432 Interleukin-15 signaling 0.185177 0.732
R-HSA-3214842 HDMs demethylate histones 0.327635 0.485
R-HSA-1483166 Synthesis of PA 0.202457 0.694
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.022694 1.644
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.063920 1.194
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.245448 0.610
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.283142 0.548
R-HSA-2559583 Cellular Senescence 0.044082 1.356
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.369379 0.433
R-HSA-9645723 Diseases of programmed cell death 0.128986 0.889
R-HSA-2586552 Signaling by Leptin 0.153268 0.815
R-HSA-1834941 STING mediated induction of host immune responses 0.264535 0.578
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.272874 0.564
R-HSA-73884 Base Excision Repair 0.361546 0.442
R-HSA-162582 Signal Transduction 0.125082 0.903
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.131308 0.882
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.142358 0.847
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.047407 1.324
R-HSA-419037 NCAM1 interactions 0.109643 0.960
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.245448 0.610
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.361242 0.442
R-HSA-69620 Cell Cycle Checkpoints 0.284493 0.546
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.038393 1.416
R-HSA-9755088 Ribavirin ADME 0.292269 0.534
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.137626 0.861
R-HSA-9707616 Heme signaling 0.225782 0.646
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.063920 1.194
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.327635 0.485
R-HSA-9909396 Circadian clock 0.123283 0.909
R-HSA-9833482 PKR-mediated signaling 0.310514 0.508
R-HSA-9694631 Maturation of nucleoprotein 0.264535 0.578
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.263439 0.579
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.101526 0.993
R-HSA-156711 Polo-like kinase mediated events 0.255052 0.593
R-HSA-162599 Late Phase of HIV Life Cycle 0.336056 0.474
R-HSA-2262752 Cellular responses to stress 0.118842 0.925
R-HSA-5358508 Mismatch Repair 0.255052 0.593
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.277590 0.557
R-HSA-9651496 Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 0.235720 0.628
R-HSA-8953897 Cellular responses to stimuli 0.071823 1.144
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.085843 1.066
R-HSA-2559580 Oxidative Stress Induced Senescence 0.058348 1.234
R-HSA-9855142 Cellular responses to mechanical stimuli 0.219317 0.659
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.195545 0.709
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.245448 0.610
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.287016 0.542
R-HSA-375165 NCAM signaling for neurite out-growth 0.225782 0.646
R-HSA-5620971 Pyroptosis 0.353001 0.452
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.205781 0.687
R-HSA-1266695 Interleukin-7 signaling 0.327635 0.485
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.264535 0.578
R-HSA-982772 Growth hormone receptor signaling 0.310178 0.508
R-HSA-75153 Apoptotic execution phase 0.152434 0.817
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.255052 0.593
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.301280 0.521
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.207101 0.684
R-HSA-8986944 Transcriptional Regulation by MECP2 0.366122 0.436
R-HSA-381038 XBP1(S) activates chaperone genes 0.343125 0.465
R-HSA-381070 IRE1alpha activates chaperones 0.370686 0.431
R-HSA-1483257 Phospholipid metabolism 0.377013 0.424
R-HSA-1257604 PIP3 activates AKT signaling 0.377013 0.424
R-HSA-399719 Trafficking of AMPA receptors 0.377413 0.423
R-HSA-186763 Downstream signal transduction 0.377413 0.423
R-HSA-73887 Death Receptor Signaling 0.377663 0.423
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.379590 0.421
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.384297 0.415
R-HSA-69190 DNA strand elongation 0.385346 0.414
R-HSA-9610379 HCMV Late Events 0.387995 0.411
R-HSA-162587 HIV Life Cycle 0.387995 0.411
R-HSA-9711097 Cellular response to starvation 0.391430 0.407
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.393177 0.405
R-HSA-1839124 FGFR1 mutant receptor activation 0.393177 0.405
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.393177 0.405
R-HSA-354192 Integrin signaling 0.393177 0.405
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.393177 0.405
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.393177 0.405
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.397781 0.400
R-HSA-74160 Gene expression (Transcription) 0.402874 0.395
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.408544 0.389
R-HSA-1980145 Signaling by NOTCH2 0.408544 0.389
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.408544 0.389
R-HSA-5696400 Dual Incision in GG-NER 0.408544 0.389
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.408544 0.389
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.408544 0.389
R-HSA-5205647 Mitophagy 0.408544 0.389
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.408544 0.389
R-HSA-193704 p75 NTR receptor-mediated signalling 0.411128 0.386
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.413898 0.383
R-HSA-5610787 Hedgehog 'off' state 0.415545 0.381
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.416081 0.381
R-HSA-917977 Transferrin endocytosis and recycling 0.416081 0.381
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.416081 0.381
R-HSA-2559585 Oncogene Induced Senescence 0.416081 0.381
R-HSA-212300 PRC2 methylates histones and DNA 0.423523 0.373
R-HSA-74158 RNA Polymerase III Transcription 0.423523 0.373
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.423523 0.373
R-HSA-9682385 FLT3 signaling in disease 0.423523 0.373
R-HSA-114604 GPVI-mediated activation cascade 0.423523 0.373
R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.423523 0.373
R-HSA-422475 Axon guidance 0.437723 0.359
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.438125 0.358
R-HSA-74217 Purine salvage 0.438125 0.358
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.438125 0.358
R-HSA-8875878 MET promotes cell motility 0.438125 0.358
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.445287 0.351
R-HSA-71336 Pentose phosphate pathway 0.445287 0.351
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.445287 0.351
R-HSA-201556 Signaling by ALK 0.445287 0.351
R-HSA-112315 Transmission across Chemical Synapses 0.447289 0.349
R-HSA-69239 Synthesis of DNA 0.450262 0.347
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.452254 0.345
R-HSA-9678108 SARS-CoV-1 Infection 0.452254 0.345
R-HSA-202433 Generation of second messenger molecules 0.452358 0.345
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.452358 0.345
R-HSA-451927 Interleukin-2 family signaling 0.452358 0.345
R-HSA-177243 Interactions of Rev with host cellular proteins 0.452358 0.345
R-HSA-9609646 HCMV Infection 0.454245 0.343
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.459340 0.338
R-HSA-9607240 FLT3 Signaling 0.459340 0.338
R-HSA-8853884 Transcriptional Regulation by VENTX 0.459340 0.338
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.459340 0.338
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.466233 0.331
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.466233 0.331
R-HSA-5655302 Signaling by FGFR1 in disease 0.466233 0.331
R-HSA-1483249 Inositol phosphate metabolism 0.471364 0.327
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.473038 0.325
R-HSA-165159 MTOR signalling 0.473038 0.325
R-HSA-110329 Cleavage of the damaged pyrimidine 0.473038 0.325
R-HSA-73928 Depyrimidination 0.473038 0.325
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.473038 0.325
R-HSA-9710421 Defective pyroptosis 0.479758 0.319
R-HSA-1433557 Signaling by SCF-KIT 0.479758 0.319
R-HSA-8854214 TBC/RABGAPs 0.479758 0.319
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.491976 0.308
R-HSA-9006925 Intracellular signaling by second messengers 0.493895 0.306
R-HSA-5653656 Vesicle-mediated transport 0.494182 0.306
R-HSA-373760 L1CAM interactions 0.496038 0.304
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.499408 0.302
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.499408 0.302
R-HSA-9675135 Diseases of DNA repair 0.499408 0.302
R-HSA-2299718 Condensation of Prophase Chromosomes 0.499408 0.302
R-HSA-9839373 Signaling by TGFBR3 0.499408 0.302
R-HSA-5357905 Regulation of TNFR1 signaling 0.499408 0.302
R-HSA-5617833 Cilium Assembly 0.500987 0.300
R-HSA-9711123 Cellular response to chemical stress 0.503854 0.298
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.504099 0.297
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.505793 0.296
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.505793 0.296
R-HSA-9675108 Nervous system development 0.508416 0.294
R-HSA-9694516 SARS-CoV-2 Infection 0.510714 0.292
R-HSA-9031628 NGF-stimulated transcription 0.512096 0.291
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.516035 0.287
R-HSA-73893 DNA Damage Bypass 0.518320 0.285
R-HSA-157858 Gap junction trafficking and regulation 0.518320 0.285
R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.518320 0.285
R-HSA-73857 RNA Polymerase II Transcription 0.527745 0.278
R-HSA-912446 Meiotic recombination 0.530531 0.275
R-HSA-3371571 HSF1-dependent transactivation 0.530531 0.275
R-HSA-194138 Signaling by VEGF 0.535503 0.271
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.536520 0.270
R-HSA-72187 mRNA 3'-end processing 0.536520 0.270
R-HSA-73772 RNA Polymerase I Promoter Escape 0.536520 0.270
R-HSA-112382 Formation of RNA Pol II elongation complex 0.536520 0.270
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.536520 0.270
R-HSA-9658195 Leishmania infection 0.538434 0.269
R-HSA-9824443 Parasitic Infection Pathways 0.538434 0.269
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.542434 0.266
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.542434 0.266
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.542434 0.266
R-HSA-445355 Smooth Muscle Contraction 0.542434 0.266
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.546925 0.262
R-HSA-72649 Translation initiation complex formation 0.548272 0.261
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.548272 0.261
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.548272 0.261
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.548272 0.261
R-HSA-5357801 Programmed Cell Death 0.550450 0.259
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.554036 0.256
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.554036 0.256
R-HSA-5673001 RAF/MAP kinase cascade 0.559106 0.253
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.559727 0.252
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.559727 0.252
R-HSA-72702 Ribosomal scanning and start codon recognition 0.559727 0.252
R-HSA-5578775 Ion homeostasis 0.559727 0.252
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.559727 0.252
R-HSA-75893 TNF signaling 0.559727 0.252
R-HSA-5576891 Cardiac conduction 0.561847 0.250
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.565437 0.248
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.570893 0.243
R-HSA-6782135 Dual incision in TC-NER 0.570893 0.243
R-HSA-397014 Muscle contraction 0.571169 0.243
R-HSA-6798695 Neutrophil degranulation 0.575242 0.240
R-HSA-194441 Metabolism of non-coding RNA 0.576370 0.239
R-HSA-191859 snRNP Assembly 0.576370 0.239
R-HSA-180786 Extension of Telomeres 0.576370 0.239
R-HSA-429914 Deadenylation-dependent mRNA decay 0.576370 0.239
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.576370 0.239
R-HSA-5684996 MAPK1/MAPK3 signaling 0.576782 0.239
R-HSA-8943724 Regulation of PTEN gene transcription 0.581778 0.235
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.581778 0.235
R-HSA-163685 Integration of energy metabolism 0.583570 0.234
R-HSA-73856 RNA Polymerase II Transcription Termination 0.587116 0.231
R-HSA-8956321 Nucleotide salvage 0.587116 0.231
R-HSA-5358351 Signaling by Hedgehog 0.590633 0.229
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.592387 0.227
R-HSA-6784531 tRNA processing in the nucleus 0.592387 0.227
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.592387 0.227
R-HSA-186797 Signaling by PDGF 0.592387 0.227
R-HSA-381119 Unfolded Protein Response (UPR) 0.594131 0.226
R-HSA-112316 Neuronal System 0.597428 0.224
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.597591 0.224
R-HSA-8848021 Signaling by PTK6 0.597591 0.224
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.597591 0.224
R-HSA-936837 Ion transport by P-type ATPases 0.602729 0.220
R-HSA-9679506 SARS-CoV Infections 0.607148 0.217
R-HSA-8856828 Clathrin-mediated endocytosis 0.611288 0.214
R-HSA-162906 HIV Infection 0.613539 0.212
R-HSA-5693606 DNA Double Strand Break Response 0.617754 0.209
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.621316 0.207
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.622635 0.206
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.622635 0.206
R-HSA-5218859 Regulated Necrosis 0.622635 0.206
R-HSA-166520 Signaling by NTRKs 0.627890 0.202
R-HSA-69202 Cyclin E associated events during G1/S transition 0.632213 0.199
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.632213 0.199
R-HSA-1852241 Organelle biogenesis and maintenance 0.634231 0.198
R-HSA-9856651 MITF-M-dependent gene expression 0.634375 0.198
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.636911 0.196
R-HSA-5632684 Hedgehog 'on' state 0.636911 0.196
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.636911 0.196
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.637585 0.195
R-HSA-212436 Generic Transcription Pathway 0.638081 0.195
R-HSA-74259 Purine catabolism 0.641549 0.193
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.641549 0.193
R-HSA-69306 DNA Replication 0.643938 0.191
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.646128 0.190
R-HSA-69052 Switching of origins to a post-replicative state 0.646128 0.190
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.647082 0.189
R-HSA-157118 Signaling by NOTCH 0.647931 0.188
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.650649 0.187
R-HSA-1226099 Signaling by FGFR in disease 0.650649 0.187
R-HSA-9013694 Signaling by NOTCH4 0.650649 0.187
R-HSA-1222556 ROS and RNS production in phagocytes 0.650649 0.187
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.655112 0.184
R-HSA-71403 Citric acid cycle (TCA cycle) 0.655112 0.184
R-HSA-917937 Iron uptake and transport 0.655112 0.184
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.655112 0.184
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.659519 0.181
R-HSA-9694635 Translation of Structural Proteins 0.663869 0.178
R-HSA-9006936 Signaling by TGFB family members 0.665486 0.177
R-HSA-73864 RNA Polymerase I Transcription 0.668165 0.175
R-HSA-383280 Nuclear Receptor transcription pathway 0.668165 0.175
R-HSA-109581 Apoptosis 0.671448 0.173
R-HSA-9659379 Sensory processing of sound 0.672405 0.172
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.672405 0.172
R-HSA-421270 Cell-cell junction organization 0.675305 0.171
R-HSA-6806834 Signaling by MET 0.676592 0.170
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.680725 0.167
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.684806 0.164
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.684806 0.164
R-HSA-9707564 Cytoprotection by HMOX1 0.688835 0.162
R-HSA-5683057 MAPK family signaling cascades 0.692594 0.160
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.692813 0.159
R-HSA-1500620 Meiosis 0.696740 0.157
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.700617 0.155
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.704445 0.152
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.705431 0.152
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.705431 0.152
R-HSA-9824446 Viral Infection Pathways 0.714336 0.146
R-HSA-76002 Platelet activation, signaling and aggregation 0.727419 0.138
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.729910 0.137
R-HSA-68867 Assembly of the pre-replicative complex 0.733365 0.135
R-HSA-446728 Cell junction organization 0.735785 0.133
R-HSA-9837999 Mitochondrial protein degradation 0.736776 0.133
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.737844 0.132
R-HSA-375276 Peptide ligand-binding receptors 0.738906 0.131
R-HSA-72689 Formation of a pool of free 40S subunits 0.743468 0.129
R-HSA-983712 Ion channel transport 0.746157 0.127
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.746751 0.127
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.746751 0.127
R-HSA-6807878 COPI-mediated anterograde transport 0.746751 0.127
R-HSA-157579 Telomere Maintenance 0.749991 0.125
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.749991 0.125
R-HSA-8957275 Post-translational protein phosphorylation 0.753191 0.123
R-HSA-422356 Regulation of insulin secretion 0.753191 0.123
R-HSA-3214847 HATs acetylate histones 0.756349 0.121
R-HSA-192105 Synthesis of bile acids and bile salts 0.756349 0.121
R-HSA-72163 mRNA Splicing - Major Pathway 0.757859 0.120
R-HSA-9609690 HCMV Early Events 0.762409 0.118
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.762409 0.118
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.771549 0.113
R-HSA-9860931 Response of endothelial cells to shear stress 0.771549 0.113
R-HSA-9833110 RSV-host interactions 0.774474 0.111
R-HSA-5696398 Nucleotide Excision Repair 0.777361 0.109
R-HSA-376176 Signaling by ROBO receptors 0.777755 0.109
R-HSA-1483206 Glycerophospholipid biosynthesis 0.777755 0.109
R-HSA-9692914 SARS-CoV-1-host interactions 0.780212 0.108
R-HSA-72172 mRNA Splicing 0.781979 0.107
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.785804 0.105
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.785804 0.105
R-HSA-1236975 Antigen processing-Cross presentation 0.785804 0.105
R-HSA-2672351 Stimuli-sensing channels 0.785804 0.105
R-HSA-69002 DNA Replication Pre-Initiation 0.788548 0.103
R-HSA-202403 TCR signaling 0.791256 0.102
R-HSA-194068 Bile acid and bile salt metabolism 0.791256 0.102
R-HSA-9730414 MITF-M-regulated melanocyte development 0.800127 0.097
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.804287 0.095
R-HSA-1500931 Cell-Cell communication 0.805469 0.094
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.806795 0.093
R-HSA-2029485 Role of phospholipids in phagocytosis 0.809270 0.092
R-HSA-418990 Adherens junctions interactions 0.809623 0.092
R-HSA-72737 Cap-dependent Translation Initiation 0.811714 0.091
R-HSA-72613 Eukaryotic Translation Initiation 0.811714 0.091
R-HSA-9007101 Rab regulation of trafficking 0.814127 0.089
R-HSA-1592230 Mitochondrial biogenesis 0.814127 0.089
R-HSA-8951664 Neddylation 0.815127 0.089
R-HSA-68875 Mitotic Prophase 0.821182 0.086
R-HSA-3371556 Cellular response to heat stress 0.823474 0.084
R-HSA-9705683 SARS-CoV-2-host interactions 0.827422 0.082
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.827971 0.082
R-HSA-2132295 MHC class II antigen presentation 0.827971 0.082
R-HSA-6809371 Formation of the cornified envelope 0.830176 0.081
R-HSA-162909 Host Interactions of HIV factors 0.830176 0.081
R-HSA-69206 G1/S Transition 0.834503 0.079
R-HSA-3247509 Chromatin modifying enzymes 0.837372 0.077
R-HSA-69481 G2/M Checkpoints 0.838720 0.076
R-HSA-8956319 Nucleotide catabolism 0.842830 0.074
R-HSA-1474165 Reproduction 0.846836 0.072
R-HSA-9843745 Adipogenesis 0.848801 0.071
R-HSA-1474228 Degradation of the extracellular matrix 0.850740 0.070
R-HSA-4839726 Chromatin organization 0.860024 0.065
R-HSA-9018519 Estrogen-dependent gene expression 0.860073 0.065
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.861868 0.065
R-HSA-1643685 Disease 0.864667 0.063
R-HSA-6807070 PTEN Regulation 0.865391 0.063
R-HSA-199977 ER to Golgi Anterograde Transport 0.880169 0.055
R-HSA-9679191 Potential therapeutics for SARS 0.884727 0.053
R-HSA-1989781 PPARA activates gene expression 0.891944 0.050
R-HSA-5663205 Infectious disease 0.892302 0.049
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.894703 0.048
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.902057 0.045
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.912149 0.040
R-HSA-72306 tRNA processing 0.912149 0.040
R-HSA-418594 G alpha (i) signalling events 0.912992 0.040
R-HSA-418555 G alpha (s) signalling events 0.913279 0.039
R-HSA-5689880 Ub-specific processing proteases 0.915495 0.038
R-HSA-168255 Influenza Infection 0.921812 0.035
R-HSA-8953854 Metabolism of RNA 0.924897 0.034
R-HSA-3781865 Diseases of glycosylation 0.926716 0.033
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.930418 0.031
R-HSA-168249 Innate Immune System 0.933053 0.030
R-HSA-8957322 Metabolism of steroids 0.935700 0.029
R-HSA-1474244 Extracellular matrix organization 0.940326 0.027
R-HSA-948021 Transport to the Golgi and subsequent modification 0.941968 0.026
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.942716 0.026
R-HSA-388396 GPCR downstream signalling 0.943521 0.025
R-HSA-6805567 Keratinization 0.945612 0.024
R-HSA-109582 Hemostasis 0.947692 0.023
R-HSA-3700989 Transcriptional Regulation by TP53 0.949501 0.023
R-HSA-9748784 Drug ADME 0.953457 0.021
R-HSA-72312 rRNA processing 0.961196 0.017
R-HSA-15869 Metabolism of nucleotides 0.963162 0.016
R-HSA-8939211 ESR-mediated signaling 0.963638 0.016
R-HSA-1280218 Adaptive Immune System 0.966244 0.015
R-HSA-913531 Interferon Signaling 0.966406 0.015
R-HSA-372790 Signaling by GPCR 0.970680 0.013
R-HSA-5688426 Deubiquitination 0.971228 0.013
R-HSA-416476 G alpha (q) signalling events 0.974409 0.011
R-HSA-5668914 Diseases of metabolism 0.979381 0.009
R-HSA-500792 GPCR ligand binding 0.985319 0.006
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.990634 0.004
R-HSA-9006931 Signaling by Nuclear Receptors 0.992979 0.003
R-HSA-1266738 Developmental Biology 0.996145 0.002
R-HSA-446203 Asparagine N-linked glycosylation 0.996806 0.001
R-HSA-72766 Translation 0.997087 0.001
R-HSA-71291 Metabolism of amino acids and derivatives 0.997731 0.001
R-HSA-449147 Signaling by Interleukins 0.997912 0.001
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.997932 0.001
R-HSA-168256 Immune System 0.999295 0.000
R-HSA-1280215 Cytokine Signaling in Immune system 0.999656 0.000
R-HSA-556833 Metabolism of lipids 0.999739 0.000
R-HSA-382551 Transport of small molecules 0.999808 0.000
R-HSA-597592 Post-translational protein modification 0.999841 0.000
R-HSA-392499 Metabolism of proteins 0.999999 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CDC7CDC7 0.882 0.249 1 0.890
COTCOT 0.877 0.067 2 0.765
PIM3PIM3 0.875 0.192 -3 0.840
CLK3CLK3 0.875 0.236 1 0.796
MOSMOS 0.872 0.174 1 0.884
NDR2NDR2 0.868 0.104 -3 0.832
PRKD1PRKD1 0.867 0.210 -3 0.827
RSK2RSK2 0.867 0.185 -3 0.785
HIPK4HIPK4 0.867 0.210 1 0.732
PRPKPRPK 0.866 -0.059 -1 0.860
CAMK1BCAMK1B 0.865 0.091 -3 0.862
SRPK1SRPK1 0.864 0.194 -3 0.777
NLKNLK 0.864 0.063 1 0.801
IKKBIKKB 0.863 -0.046 -2 0.766
RAF1RAF1 0.862 -0.016 1 0.834
CDKL1CDKL1 0.862 0.107 -3 0.828
P90RSKP90RSK 0.862 0.147 -3 0.790
PIM1PIM1 0.861 0.172 -3 0.791
MTORMTOR 0.861 -0.058 1 0.774
TBK1TBK1 0.861 -0.057 1 0.729
PRKD2PRKD2 0.861 0.173 -3 0.773
GRK1GRK1 0.860 0.103 -2 0.791
CDKL5CDKL5 0.859 0.118 -3 0.821
ERK5ERK5 0.859 0.035 1 0.771
ATRATR 0.859 0.002 1 0.769
DAPK2DAPK2 0.859 0.159 -3 0.864
NDR1NDR1 0.859 0.064 -3 0.826
DSTYKDSTYK 0.859 -0.041 2 0.778
IKKEIKKE 0.859 -0.062 1 0.727
PKN3PKN3 0.859 0.054 -3 0.826
SKMLCKSKMLCK 0.858 0.107 -2 0.903
RSK3RSK3 0.858 0.123 -3 0.777
BMPR2BMPR2 0.858 -0.093 -2 0.898
CAMK2GCAMK2G 0.858 -0.071 2 0.735
CAMLCKCAMLCK 0.858 0.104 -2 0.901
PDHK4PDHK4 0.857 -0.226 1 0.832
GCN2GCN2 0.857 -0.176 2 0.724
BMPR1BBMPR1B 0.857 0.226 1 0.881
CHAK2CHAK2 0.857 0.086 -1 0.818
AURCAURC 0.856 0.159 -2 0.726
KISKIS 0.856 0.088 1 0.658
GRK5GRK5 0.855 -0.037 -3 0.851
ULK2ULK2 0.855 -0.154 2 0.720
LATS2LATS2 0.855 0.061 -5 0.784
ICKICK 0.855 0.118 -3 0.855
MAPKAPK2MAPKAPK2 0.855 0.135 -3 0.744
NUAK2NUAK2 0.855 0.064 -3 0.831
P70S6KBP70S6KB 0.855 0.106 -3 0.800
AMPKA1AMPKA1 0.855 0.098 -3 0.837
TGFBR2TGFBR2 0.855 0.009 -2 0.800
NIKNIK 0.855 0.023 -3 0.867
SRPK2SRPK2 0.855 0.170 -3 0.708
NEK6NEK6 0.854 -0.020 -2 0.867
MAPKAPK3MAPKAPK3 0.854 0.095 -3 0.776
GRK6GRK6 0.854 0.040 1 0.859
PDHK1PDHK1 0.854 -0.167 1 0.808
TSSK2TSSK2 0.853 0.098 -5 0.846
PKACGPKACG 0.853 0.095 -2 0.804
RSK4RSK4 0.853 0.178 -3 0.757
CAMK2DCAMK2D 0.852 0.024 -3 0.838
MARK4MARK4 0.852 0.018 4 0.846
PKN2PKN2 0.852 0.045 -3 0.824
SRPK3SRPK3 0.851 0.162 -3 0.757
MST4MST4 0.851 0.009 2 0.761
AMPKA2AMPKA2 0.851 0.108 -3 0.808
LATS1LATS1 0.850 0.152 -3 0.839
WNK1WNK1 0.850 -0.031 -2 0.902
IKKAIKKA 0.850 -0.020 -2 0.749
NEK7NEK7 0.849 -0.134 -3 0.860
TGFBR1TGFBR1 0.849 0.106 -2 0.805
CLK2CLK2 0.849 0.223 -3 0.757
TSSK1TSSK1 0.849 0.092 -3 0.850
DYRK2DYRK2 0.849 0.094 1 0.660
RIPK3RIPK3 0.848 -0.105 3 0.764
ALK4ALK4 0.848 0.086 -2 0.837
CAMK2ACAMK2A 0.848 0.094 2 0.710
PKCDPKCD 0.848 0.043 2 0.706
MLK1MLK1 0.848 -0.129 2 0.718
CAMK2BCAMK2B 0.848 0.063 2 0.698
FAM20CFAM20C 0.847 0.041 2 0.560
HUNKHUNK 0.847 -0.128 2 0.708
PIM2PIM2 0.846 0.172 -3 0.759
PKACBPKACB 0.846 0.154 -2 0.742
CDK8CDK8 0.846 0.022 1 0.640
MSK1MSK1 0.846 0.124 -3 0.762
PRKD3PRKD3 0.846 0.111 -3 0.753
MSK2MSK2 0.846 0.064 -3 0.768
CLK4CLK4 0.845 0.136 -3 0.773
ULK1ULK1 0.845 -0.192 -3 0.822
PLK1PLK1 0.845 0.002 -2 0.818
BCKDKBCKDK 0.845 -0.172 -1 0.784
MASTLMASTL 0.845 -0.203 -2 0.840
GRK7GRK7 0.844 0.101 1 0.784
AURBAURB 0.844 0.114 -2 0.724
ACVR2BACVR2B 0.844 0.124 -2 0.804
PAK1PAK1 0.844 0.041 -2 0.842
CDK19CDK19 0.843 0.039 1 0.604
CLK1CLK1 0.843 0.144 -3 0.749
HIPK2HIPK2 0.843 0.138 1 0.581
ACVR2AACVR2A 0.843 0.098 -2 0.791
DLKDLK 0.843 -0.126 1 0.818
NIM1NIM1 0.843 -0.064 3 0.811
CAMK4CAMK4 0.842 -0.016 -3 0.806
QSKQSK 0.842 0.071 4 0.827
HIPK1HIPK1 0.842 0.139 1 0.677
WNK3WNK3 0.842 -0.227 1 0.771
NEK9NEK9 0.842 -0.149 2 0.749
GRK4GRK4 0.841 -0.130 -2 0.826
PAK3PAK3 0.841 0.010 -2 0.843
AURAAURA 0.841 0.102 -2 0.694
PKG2PKG2 0.841 0.111 -2 0.744
CDK7CDK7 0.841 0.033 1 0.656
PRKXPRKX 0.841 0.170 -3 0.674
MLK2MLK2 0.840 -0.117 2 0.745
MELKMELK 0.840 0.015 -3 0.794
ATMATM 0.840 -0.065 1 0.710
AKT2AKT2 0.840 0.132 -3 0.706
SGK3SGK3 0.840 0.110 -3 0.758
BRSK1BRSK1 0.840 0.036 -3 0.786
IRE1IRE1 0.840 -0.073 1 0.723
ANKRD3ANKRD3 0.839 -0.165 1 0.816
MYLK4MYLK4 0.839 0.080 -2 0.832
JNK2JNK2 0.839 0.068 1 0.608
ALK2ALK2 0.839 0.068 -2 0.813
CDK13CDK13 0.839 0.027 1 0.629
RIPK1RIPK1 0.839 -0.180 1 0.765
MLK3MLK3 0.839 -0.063 2 0.659
JNK3JNK3 0.838 0.044 1 0.637
BMPR1ABMPR1A 0.838 0.159 1 0.861
PKCAPKCA 0.838 0.033 2 0.651
MEK1MEK1 0.838 -0.090 2 0.771
CDK5CDK5 0.838 0.056 1 0.669
IRE2IRE2 0.837 -0.029 2 0.687
DYRK1ADYRK1A 0.837 0.104 1 0.698
PAK2PAK2 0.837 0.015 -2 0.826
PKCBPKCB 0.837 0.004 2 0.652
PKCGPKCG 0.837 -0.001 2 0.654
PAK6PAK6 0.837 0.059 -2 0.773
CDK1CDK1 0.837 0.049 1 0.628
TTBK2TTBK2 0.837 -0.195 2 0.643
HIPK3HIPK3 0.836 0.110 1 0.671
NUAK1NUAK1 0.836 0.003 -3 0.785
MNK1MNK1 0.836 0.038 -2 0.859
QIKQIK 0.836 -0.052 -3 0.827
SIKSIK 0.836 0.038 -3 0.763
PKRPKR 0.836 -0.060 1 0.782
CDK18CDK18 0.836 0.052 1 0.587
VRK2VRK2 0.836 -0.152 1 0.819
PHKG1PHKG1 0.836 -0.022 -3 0.814
MNK2MNK2 0.835 -0.000 -2 0.848
CHAK1CHAK1 0.835 -0.053 2 0.752
MARK3MARK3 0.835 0.044 4 0.781
NEK2NEK2 0.835 -0.058 2 0.750
DRAK1DRAK1 0.834 0.029 1 0.829
YSK4YSK4 0.834 -0.110 1 0.765
P38AP38A 0.834 0.035 1 0.675
PLK3PLK3 0.834 -0.069 2 0.693
GRK2GRK2 0.834 0.023 -2 0.715
P38BP38B 0.833 0.052 1 0.612
MARK2MARK2 0.833 0.012 4 0.753
MLK4MLK4 0.832 -0.090 2 0.644
PKCHPKCH 0.832 -0.019 2 0.642
CDK12CDK12 0.832 0.026 1 0.602
CHK1CHK1 0.832 0.015 -3 0.801
BRSK2BRSK2 0.832 -0.039 -3 0.802
DNAPKDNAPK 0.832 -0.029 1 0.652
DYRK4DYRK4 0.832 0.073 1 0.600
CDK9CDK9 0.832 0.004 1 0.634
P70S6KP70S6K 0.832 0.090 -3 0.723
ERK1ERK1 0.831 0.026 1 0.603
PKACAPKACA 0.831 0.129 -2 0.697
DYRK1BDYRK1B 0.831 0.087 1 0.630
PASKPASK 0.831 0.107 -3 0.857
PKCZPKCZ 0.830 -0.045 2 0.709
SSTKSSTK 0.830 0.056 4 0.807
TLK2TLK2 0.830 -0.088 1 0.736
P38GP38G 0.830 0.033 1 0.539
DCAMKL1DCAMKL1 0.830 0.022 -3 0.771
SNRKSNRK 0.830 -0.123 2 0.655
SMG1SMG1 0.829 -0.083 1 0.708
CDK14CDK14 0.829 0.057 1 0.632
DYRK3DYRK3 0.829 0.103 1 0.672
CDK17CDK17 0.828 0.022 1 0.543
MPSK1MPSK1 0.828 0.102 1 0.736
CAMK1GCAMK1G 0.828 0.006 -3 0.773
CK2A2CK2A2 0.828 0.158 1 0.819
BRAFBRAF 0.827 -0.081 -4 0.829
AKT1AKT1 0.827 0.116 -3 0.714
SMMLCKSMMLCK 0.827 0.059 -3 0.824
DAPK3DAPK3 0.827 0.131 -3 0.797
MARK1MARK1 0.827 -0.011 4 0.795
MAPKAPK5MAPKAPK5 0.826 -0.049 -3 0.740
CDK10CDK10 0.826 0.091 1 0.618
ERK2ERK2 0.826 -0.026 1 0.645
CK1ECK1E 0.826 -0.000 -3 0.561
P38DP38D 0.826 0.067 1 0.537
PRP4PRP4 0.825 -0.019 -3 0.717
PLK4PLK4 0.824 -0.150 2 0.598
PERKPERK 0.824 -0.145 -2 0.840
CAMK1DCAMK1D 0.824 0.070 -3 0.697
CDK3CDK3 0.824 0.042 1 0.563
DAPK1DAPK1 0.823 0.133 -3 0.785
PINK1PINK1 0.823 -0.101 1 0.768
MST3MST3 0.823 -0.014 2 0.745
MEK5MEK5 0.823 -0.224 2 0.751
WNK4WNK4 0.822 -0.116 -2 0.892
MEKK1MEKK1 0.822 -0.176 1 0.763
GSK3BGSK3B 0.822 0.030 4 0.518
TLK1TLK1 0.822 -0.112 -2 0.831
ZAKZAK 0.822 -0.162 1 0.755
HRIHRI 0.822 -0.176 -2 0.860
GRK3GRK3 0.822 0.014 -2 0.664
CDK16CDK16 0.821 0.040 1 0.557
NEK5NEK5 0.821 -0.117 1 0.772
PKCTPKCT 0.821 -0.011 2 0.654
CDK2CDK2 0.821 -0.054 1 0.706
SGK1SGK1 0.821 0.139 -3 0.634
MAKMAK 0.821 0.162 -2 0.788
CK1DCK1D 0.820 0.017 -3 0.515
DCAMKL2DCAMKL2 0.820 -0.040 -3 0.795
AKT3AKT3 0.820 0.134 -3 0.652
GSK3AGSK3A 0.820 0.049 4 0.523
MEKK3MEKK3 0.820 -0.211 1 0.783
PHKG2PHKG2 0.819 -0.036 -3 0.776
CK2A1CK2A1 0.819 0.145 1 0.806
MEKK2MEKK2 0.819 -0.168 2 0.725
IRAK4IRAK4 0.819 -0.130 1 0.726
TAO3TAO3 0.818 -0.053 1 0.774
PKCIPKCI 0.818 -0.004 2 0.676
GAKGAK 0.817 0.013 1 0.828
BUB1BUB1 0.817 0.185 -5 0.821
ERK7ERK7 0.817 0.009 2 0.503
PKCEPKCE 0.816 0.045 2 0.641
CK1A2CK1A2 0.816 0.004 -3 0.514
LKB1LKB1 0.816 0.003 -3 0.817
PDK1PDK1 0.816 -0.042 1 0.764
JNK1JNK1 0.816 0.020 1 0.604
CK1G1CK1G1 0.815 -0.044 -3 0.556
CAMKK1CAMKK1 0.815 -0.122 -2 0.785
PAK5PAK5 0.815 0.018 -2 0.708
MOKMOK 0.815 0.139 1 0.678
PKN1PKN1 0.814 0.039 -3 0.732
EEF2KEEF2K 0.814 0.010 3 0.888
GCKGCK 0.814 0.030 1 0.804
PAK4PAK4 0.813 0.023 -2 0.715
NEK8NEK8 0.813 -0.159 2 0.740
TAO2TAO2 0.812 -0.087 2 0.766
CHK2CHK2 0.812 0.073 -3 0.649
CDK6CDK6 0.812 0.043 1 0.607
CAMKK2CAMKK2 0.812 -0.089 -2 0.788
TNIKTNIK 0.812 0.044 3 0.908
MINKMINK 0.812 0.011 1 0.769
MRCKAMRCKA 0.812 0.092 -3 0.753
HGKHGK 0.811 0.010 3 0.907
CDK4CDK4 0.811 0.038 1 0.587
NEK11NEK11 0.811 -0.179 1 0.779
ROCK2ROCK2 0.811 0.103 -3 0.776
MRCKBMRCKB 0.811 0.089 -3 0.738
HPK1HPK1 0.810 0.038 1 0.789
CAMK1ACAMK1A 0.810 0.068 -3 0.671
NEK4NEK4 0.810 -0.090 1 0.744
PLK2PLK2 0.809 -0.044 -3 0.776
IRAK1IRAK1 0.809 -0.252 -1 0.733
TTBK1TTBK1 0.809 -0.211 2 0.570
MEKK6MEKK6 0.808 -0.095 1 0.758
PBKPBK 0.808 0.069 1 0.743
SBKSBK 0.808 0.093 -3 0.599
KHS1KHS1 0.808 0.074 1 0.760
MST2MST2 0.808 -0.109 1 0.794
TAK1TAK1 0.807 -0.094 1 0.800
MAP3K15MAP3K15 0.807 -0.100 1 0.737
NEK1NEK1 0.806 -0.060 1 0.748
KHS2KHS2 0.806 0.087 1 0.780
LOKLOK 0.806 -0.035 -2 0.812
LRRK2LRRK2 0.805 -0.125 2 0.774
DMPK1DMPK1 0.804 0.124 -3 0.758
CRIKCRIK 0.802 0.137 -3 0.725
VRK1VRK1 0.802 -0.188 2 0.755
PDHK3_TYRPDHK3_TYR 0.802 0.221 4 0.903
MEK2MEK2 0.801 -0.183 2 0.755
MST1MST1 0.800 -0.110 1 0.768
STK33STK33 0.798 -0.169 2 0.565
SLKSLK 0.798 -0.087 -2 0.742
YSK1YSK1 0.797 -0.092 2 0.727
PKG1PKG1 0.797 0.042 -2 0.667
RIPK2RIPK2 0.796 -0.252 1 0.713
ROCK1ROCK1 0.796 0.074 -3 0.746
MAP2K4_TYRMAP2K4_TYR 0.794 0.093 -1 0.872
TESK1_TYRTESK1_TYR 0.792 0.041 3 0.915
MAP2K6_TYRMAP2K6_TYR 0.791 0.034 -1 0.875
OSR1OSR1 0.791 -0.073 2 0.728
PDHK4_TYRPDHK4_TYR 0.790 0.042 2 0.801
NEK3NEK3 0.790 -0.148 1 0.706
TTKTTK 0.790 -0.061 -2 0.822
HASPINHASPIN 0.790 -0.019 -1 0.679
BIKEBIKE 0.790 0.032 1 0.710
LIMK2_TYRLIMK2_TYR 0.789 0.096 -3 0.876
PKMYT1_TYRPKMYT1_TYR 0.789 -0.003 3 0.882
BMPR2_TYRBMPR2_TYR 0.788 0.021 -1 0.860
PDHK1_TYRPDHK1_TYR 0.788 0.016 -1 0.882
MYO3BMYO3B 0.787 -0.027 2 0.762
MAP2K7_TYRMAP2K7_TYR 0.787 -0.166 2 0.785
ASK1ASK1 0.787 -0.135 1 0.729
CK1ACK1A 0.787 0.006 -3 0.427
EPHA6EPHA6 0.787 0.047 -1 0.859
YANK3YANK3 0.787 -0.072 2 0.366
PINK1_TYRPINK1_TYR 0.785 -0.114 1 0.811
ALPHAK3ALPHAK3 0.785 -0.068 -1 0.781
TXKTXK 0.783 0.137 1 0.879
EPHB4EPHB4 0.783 0.007 -1 0.839
MYO3AMYO3A 0.783 -0.074 1 0.738
TAO1TAO1 0.779 -0.115 1 0.694
RETRET 0.779 -0.103 1 0.755
ROS1ROS1 0.779 -0.029 3 0.810
LIMK1_TYRLIMK1_TYR 0.778 -0.127 2 0.788
ABL2ABL2 0.778 0.001 -1 0.818
TYRO3TYRO3 0.778 -0.092 3 0.839
AAK1AAK1 0.777 0.083 1 0.609
TYK2TYK2 0.777 -0.126 1 0.751
FGRFGR 0.776 -0.009 1 0.831
INSRRINSRR 0.776 -0.037 3 0.775
MST1RMST1R 0.775 -0.136 3 0.845
YES1YES1 0.775 -0.039 -1 0.849
FERFER 0.775 -0.065 1 0.859
CSF1RCSF1R 0.775 -0.087 3 0.818
LCKLCK 0.774 0.047 -1 0.840
JAK2JAK2 0.774 -0.122 1 0.748
EPHA4EPHA4 0.773 -0.035 2 0.689
HCKHCK 0.773 -0.038 -1 0.836
ABL1ABL1 0.772 -0.038 -1 0.807
EPHB1EPHB1 0.772 -0.038 1 0.841
SRMSSRMS 0.772 -0.047 1 0.858
BLKBLK 0.772 0.048 -1 0.840
ITKITK 0.772 -0.025 -1 0.802
TNK2TNK2 0.772 -0.022 3 0.770
JAK3JAK3 0.772 -0.105 1 0.751
DDR1DDR1 0.772 -0.171 4 0.817
EPHB3EPHB3 0.770 -0.056 -1 0.825
NEK10_TYRNEK10_TYR 0.770 -0.023 1 0.664
STLK3STLK3 0.770 -0.212 1 0.717
EPHB2EPHB2 0.770 -0.042 -1 0.815
JAK1JAK1 0.768 0.010 1 0.709
BMXBMX 0.768 -0.007 -1 0.734
MERTKMERTK 0.768 -0.058 3 0.795
TNNI3K_TYRTNNI3K_TYR 0.767 -0.014 1 0.735
PDGFRBPDGFRB 0.766 -0.155 3 0.835
KITKIT 0.765 -0.138 3 0.819
TECTEC 0.765 -0.047 -1 0.739
FGFR2FGFR2 0.764 -0.188 3 0.805
TNK1TNK1 0.764 -0.088 3 0.818
AXLAXL 0.764 -0.118 3 0.797
FLT3FLT3 0.764 -0.156 3 0.833
ALKALK 0.763 -0.085 3 0.746
EPHA7EPHA7 0.763 -0.058 2 0.695
FYNFYN 0.762 -0.016 -1 0.822
KDRKDR 0.761 -0.150 3 0.769
PTK6PTK6 0.761 -0.138 -1 0.749
TEKTEK 0.761 -0.178 3 0.764
BTKBTK 0.760 -0.163 -1 0.767
PDGFRAPDGFRA 0.760 -0.184 3 0.831
LTKLTK 0.760 -0.122 3 0.761
FGFR1FGFR1 0.760 -0.195 3 0.789
PTK2BPTK2B 0.760 -0.016 -1 0.771
METMET 0.759 -0.132 3 0.809
WEE1_TYRWEE1_TYR 0.759 -0.090 -1 0.747
NTRK1NTRK1 0.758 -0.186 -1 0.826
EPHA3EPHA3 0.758 -0.133 2 0.672
EPHA1EPHA1 0.758 -0.112 3 0.792
INSRINSR 0.758 -0.132 3 0.764
FRKFRK 0.756 -0.109 -1 0.840
EPHA5EPHA5 0.756 -0.081 2 0.676
LYNLYN 0.755 -0.093 3 0.751
CK1G3CK1G3 0.755 -0.053 -3 0.382
ERBB2ERBB2 0.755 -0.181 1 0.745
NTRK3NTRK3 0.755 -0.119 -1 0.790
FLT1FLT1 0.755 -0.160 -1 0.839
DDR2DDR2 0.754 -0.061 3 0.746
NTRK2NTRK2 0.753 -0.205 3 0.777
PTK2PTK2 0.753 0.020 -1 0.786
EPHA8EPHA8 0.753 -0.086 -1 0.814
FGFR3FGFR3 0.753 -0.205 3 0.776
SRCSRC 0.752 -0.086 -1 0.817
YANK2YANK2 0.750 -0.110 2 0.375
FLT4FLT4 0.749 -0.233 3 0.763
SYKSYK 0.749 -0.009 -1 0.793
EGFREGFR 0.748 -0.119 1 0.660
MATKMATK 0.748 -0.142 -1 0.738
EPHA2EPHA2 0.745 -0.090 -1 0.785
CSKCSK 0.744 -0.185 2 0.698
IGF1RIGF1R 0.743 -0.131 3 0.701
FGFR4FGFR4 0.741 -0.162 -1 0.782
MUSKMUSK 0.740 -0.151 1 0.647
ERBB4ERBB4 0.737 -0.094 1 0.699
CK1G2CK1G2 0.737 -0.059 -3 0.473
FESFES 0.731 -0.114 -1 0.710
ZAP70ZAP70 0.722 -0.078 -1 0.712