Motif 209 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1X283 | SH3PXD2B | S304 | ochoa | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}. |
| B7Z1M9 | C2CD4D | S128 | ochoa | C2 calcium-dependent domain-containing protein 4D | None |
| O14490 | DLGAP1 | S932 | ochoa | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | Part of the postsynaptic scaffold in neuronal cells. |
| O14908 | GIPC1 | S68 | ochoa | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | May be involved in G protein-linked signaling. |
| O15027 | SEC16A | S1193 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15049 | N4BP3 | S176 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15056 | SYNJ2 | S1127 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15479 | MAGEB2 | S77 | ochoa | Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| O15479 | MAGEB2 | S78 | ochoa | Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen) | May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}. |
| O43561 | LAT | S91 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O43660 | PLRG1 | S119 | ochoa | Pleiotropic regulator 1 | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11101529, ECO:0000269|PubMed:11544257, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| O43683 | BUB1 | S375 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
| O60264 | SMARCA5 | S29 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60264 | SMARCA5 | S31 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60264 | SMARCA5 | S32 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O75112 | LDB3 | S508 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75128 | COBL | S1227 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75369 | FLNB | S1529 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75385 | ULK1 | S781 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75676 | RPS6KA4 | S365 | ochoa | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| O75864 | PPP1R37 | S50 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O94811 | TPPP | S35 | ochoa | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) | Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:21316364, ECO:0000269|PubMed:21995432, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:26289831, ECO:0000269|PubMed:31522887}. |
| O95071 | UBR5 | Y1746 | ochoa | E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250|UniProtKB:Q80TP3, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:21118991, ECO:0000269|PubMed:21127351, ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692, ECO:0000269|PubMed:28689657, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:33208877, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37409633, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:37478862}. |
| O95219 | SNX4 | S22 | ochoa | Sorting nexin-4 | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). {ECO:0000269|PubMed:12668730, ECO:0000269|PubMed:17994011, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622}. |
| P00519 | ABL1 | S917 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P00519 | ABL1 | S919 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P0C7T5 | ATXN1L | S208 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0DPH7 | TUBA3C | S277 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | S277 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P18031 | PTPN1 | S365 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
| P27816 | MAP4 | S768 | psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29966 | MARCKS | S81 | ochoa | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL) | Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P26645, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:23704996, ECO:0000269|PubMed:36009319, ECO:0000269|PubMed:37949888}. |
| P31269 | HOXA9 | S205 | psp | Homeobox protein Hox-A9 (Homeobox protein Hox-1G) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity). {ECO:0000250|UniProtKB:P09631, ECO:0000269|PubMed:22269951}. |
| P35568 | IRS1 | S463 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35568 | IRS1 | S1058 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P38398 | BRCA1 | S1596 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40123 | CAP2 | S259 | ochoa | Adenylyl cyclase-associated protein 2 (CAP 2) | Involved in the regulation of actin polymerization. {ECO:0000269|PubMed:30518548}. |
| P40855 | PEX19 | S66 | ochoa | Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) | Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269|PubMed:10051604, ECO:0000269|PubMed:10704444, ECO:0000269|PubMed:11259404, ECO:0000269|PubMed:11883941, ECO:0000269|PubMed:14709540, ECO:0000269|PubMed:15007061}. |
| P42694 | HELZ | S1883 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
| P52945 | PDX1 | S61 | psp | Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| P53990 | IST1 | S293 | ochoa | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| P54259 | ATN1 | S188 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55199 | ELL | S401 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P55884 | EIF3B | S119 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P67809 | YBX1 | T30 | ochoa | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P68363 | TUBA1B | S277 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | S277 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78524 | DENND2B | S105 | ochoa | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480). {ECO:0000269|PubMed:29030480, ECO:0000269|PubMed:9632734}.; FUNCTION: [Isoform 2]: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}.; FUNCTION: [Isoform 3]: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). {ECO:0000305|PubMed:10229203, ECO:0000305|PubMed:9632734}. |
| Q01974 | ROR2 | S868 | ochoa | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) | Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {ECO:0000250|UniProtKB:Q9Z138, ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:25029443}. |
| Q03111 | MLLT1 | S296 | ochoa | Protein ENL (YEATS domain-containing protein 1) | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}. |
| Q05193 | DNM1 | S795 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
| Q10586 | DBP | S156 | ochoa | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Q13367 | AP3B2 | S272 | ochoa | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Q13501 | SQSTM1 | S229 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13596 | SNX1 | S32 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q147X3 | NAA30 | S134 | ochoa | N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) | Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex (PubMed:19398576, PubMed:37891180). Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly (PubMed:19398576, PubMed:37891180). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (PubMed:37891180). Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate (PubMed:19398576). {ECO:0000269|PubMed:19398576, ECO:0000269|PubMed:37891180}. |
| Q14847 | LASP1 | S198 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q15345 | LRRC41 | S281 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15691 | MAPRE1 | S155 | ochoa|psp | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
| Q2M2I8 | AAK1 | S642 | ochoa | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269|PubMed:11877457, ECO:0000269|PubMed:11877461, ECO:0000269|PubMed:12952931, ECO:0000269|PubMed:14617351, ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069, ECO:0000269|PubMed:21464124, ECO:0000269|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269|PubMed:25653444, ECO:0000305|PubMed:31136173}. |
| Q3ZCQ8 | TIMM50 | S45 | ochoa | Mitochondrial import inner membrane translocase subunit TIM50 | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:30190335, PubMed:38828998). Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. {ECO:0000269|PubMed:15044455, ECO:0000269|PubMed:30190335, ECO:0000269|PubMed:38828998}.; FUNCTION: [Isoform 2]: May participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269|PubMed:16008839}. |
| Q5FWE3 | PRRT3 | S903 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5JTV8 | TOR1AIP1 | S40 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5T1J5 | CHCHD2P9 | S45 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q5T1J5 | CHCHD2P9 | S46 | ochoa | Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9) | None |
| Q66K74 | MAP1S | S610 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DK7 | MSL1 | S201 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6IAA8 | LAMTOR1 | S45 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
| Q6P0Q8 | MAST2 | S1717 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P2Q9 | PRPF8 | S26 | ochoa | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}. |
| Q6PEY2 | TUBA3E | S277 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PKG0 | LARP1 | S291 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6WKZ4 | RAB11FIP1 | S1171 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q71U36 | TUBA1A | S277 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L311 | ARMCX2 | S242 | ochoa | Armadillo repeat-containing X-linked protein 2 (ARM protein lost in epithelial cancers on chromosome X 2) (Protein ALEX2) | May regulate the dynamics and distribution of mitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. |
| Q7L5A3 | ATOSB | S255 | ochoa | Atos homolog protein B | Transcription regulator that may syncronize transcriptional and translational programs. {ECO:0000250|UniProtKB:Q8BR27}. |
| Q7Z2W4 | ZC3HAV1 | S249 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z7F0 | KHDC4 | S40 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q7Z7F0 | KHDC4 | S41 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q7Z7L8 | C11orf96 | S297 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86U38 | NOP9 | S58 | ochoa | Nucleolar protein 9 | None |
| Q8IU81 | IRF2BP1 | S436 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IY22 | CMIP | S660 | ochoa | C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}. |
| Q8IZ73 | RPUSD2 | S90 | ochoa | Pseudouridylate synthase RPUSD2 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 2) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. {ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}. |
| Q8N196 | SIX5 | S283 | ochoa | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}. |
| Q8N350 | CBARP | Y505 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N350 | CBARP | S621 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N684 | CPSF7 | S322 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8N9M1 | C19orf47 | S172 | ochoa | Uncharacterized protein C19orf47 | None |
| Q8NAF0 | ZNF579 | S196 | ochoa | Zinc finger protein 579 | May be involved in transcriptional regulation. |
| Q8NBI6 | XXYLT1 | S88 | ochoa | Xyloside xylosyltransferase 1 (EC 2.4.2.62) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase) | Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869). {ECO:0000269|PubMed:22117070, ECO:0000269|PubMed:8982869}. |
| Q8NEY1 | NAV1 | S1271 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8TBN0 | RAB3IL1 | S25 | ochoa | Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}. |
| Q8TF72 | SHROOM3 | S499 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WX93 | PALLD | S726 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE1 | ATRIP | S38 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WZ73 | RFFL | S35 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
| Q96B18 | DACT3 | S306 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96B97 | SH3KBP1 | S589 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96F46 | IL17RA | S629 | ochoa|psp | Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) | Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. |
| Q96S55 | WRNIP1 | S131 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q96S55 | WRNIP1 | S133 | ochoa | ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1) | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269|PubMed:15670210, ECO:0000269|PubMed:29053956}. |
| Q99583 | MNT | S210 | ochoa | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. |
| Q9BQE3 | TUBA1C | S277 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BQQ3 | GORASP1 | S243 | ochoa | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| Q9BSQ5 | CCM2 | S181 | ochoa | Cerebral cavernous malformations 2 protein (Malcavernin) | Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S114 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BTU6 | PI4K2A | S22 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BUJ2 | HNRNPUL1 | S727 | ochoa | Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) | Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}. |
| Q9C029 | TRIM7 | S107 | ochoa | E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7) | E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25851810, PubMed:32853985, PubMed:34062120). Acts as an antiviral effector against multiple viruses by targeting specific viral proteins for ubiquitination and degradation including norovirus NTPase protein or SARS-CoV-2 NSP5 and NSP8 proteins (PubMed:34062120, PubMed:35982226). Mechanistically, recognizes the C-terminal glutamine-containing motif usually generated by viral proteases that process the polyproteins and trigger their ubiquitination and subsequent degradation (PubMed:35867826, PubMed:35893676, PubMed:35982226). Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). Mediates the ubiquitination of the SIN3-HDAC chromatin remodeling complex component BRMS1 (PubMed:32853985). Modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells by ubiquitinating NCOA4, leading to its degradation (PubMed:36067704). {ECO:0000250|UniProtKB:Q923T7, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:32126128, ECO:0000269|PubMed:32853985, ECO:0000269|PubMed:34062120, ECO:0000269|PubMed:35867826, ECO:0000269|PubMed:35893676, ECO:0000269|PubMed:35982226, ECO:0000269|PubMed:36067704}.; FUNCTION: (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination. {ECO:0000269|PubMed:32641828}. |
| Q9H1R3 | MYLK2 | S120 | ochoa | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9H3S7 | PTPN23 | S1484 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9NQC3 | RTN4 | S182 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NRR5 | UBQLN4 | S135 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NXW2 | DNAJB12 | S81 | ochoa | DnaJ homolog subfamily B member 12 | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21148293, PubMed:21150129). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:21148293). Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). {ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27916661}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744). {ECO:0000269|PubMed:21673190, ECO:0000269|PubMed:24675744}. |
| Q9NZ56 | FMN2 | S317 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
| Q9NZV5 | SELENON | S30 | ochoa | Selenoprotein N (SelN) | [Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863, PubMed:19557870). {ECO:0000269|PubMed:18713863, ECO:0000269|PubMed:19557870, ECO:0000269|PubMed:25452428}.; FUNCTION: Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290). {ECO:0000269|PubMed:21131290}. |
| Q9P1Y5 | CAMSAP3 | S560 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9UGP4 | LIMD1 | S145 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UHD8 | SEPTIN9 | S59 | ochoa | Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1) | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}. |
| Q9ULM3 | YEATS2 | S372 | ochoa | YEATS domain-containing protein 2 | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27103431}. |
| Q9ULP9 | TBC1D24 | S472 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515). Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402). {ECO:0000269|PubMed:20727515, ECO:0000269|PubMed:20797691, ECO:0000269|PubMed:31257402}. |
| Q9UMN6 | KMT2B | S782 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UQ35 | SRRM2 | S2189 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQB8 | BAIAP2 | S484 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
| Q9Y2U8 | LEMD3 | S309 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
| Q9Y2X7 | GIT1 | S498 | ochoa|psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y2Y9 | KLF13 | S123 | psp | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y3Q8 | TSC22D4 | S207 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4F5 | CEP170B | S563 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | S1199 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6H1 | CHCHD2 | S45 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| Q9Y6H1 | CHCHD2 | S46 | ochoa | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP) | Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). {ECO:0000269|PubMed:23303788}. |
| Q96RD6 | PANX2 | S514 | SIGNOR | Pannexin-2 | Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q6IMP4, ECO:0000269|PubMed:36869038, ECO:0000269|PubMed:36973289}. |
| Q8TD08 | MAPK15 | S447 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q96RG2 | PASK | S996 | Sugiyama | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q9NQU5 | PAK6 | S224 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.430519e-09 | 8.845 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.938527e-09 | 8.713 |
| R-HSA-437239 | Recycling pathway of L1 | 1.972453e-09 | 8.705 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.814644e-09 | 8.551 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.424855e-09 | 8.465 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.183388e-08 | 7.927 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.760626e-08 | 7.559 |
| R-HSA-190828 | Gap junction trafficking | 2.555979e-08 | 7.592 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.882047e-08 | 7.311 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.135958e-08 | 7.289 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.062965e-07 | 6.973 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.094617e-07 | 6.961 |
| R-HSA-190861 | Gap junction assembly | 9.728805e-08 | 7.012 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.448568e-07 | 6.839 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 2.415811e-07 | 6.617 |
| R-HSA-9646399 | Aggrephagy | 2.422914e-07 | 6.616 |
| R-HSA-9663891 | Selective autophagy | 2.389710e-07 | 6.622 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.196838e-07 | 6.495 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.904039e-07 | 6.408 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.463893e-07 | 6.350 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 5.368955e-07 | 6.270 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.870334e-07 | 6.163 |
| R-HSA-68882 | Mitotic Anaphase | 1.363140e-06 | 5.865 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.423506e-06 | 5.847 |
| R-HSA-1632852 | Macroautophagy | 1.588513e-06 | 5.799 |
| R-HSA-199991 | Membrane Trafficking | 1.766010e-06 | 5.753 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 2.327115e-06 | 5.633 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.499396e-06 | 5.602 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.695652e-06 | 5.569 |
| R-HSA-373760 | L1CAM interactions | 2.614844e-06 | 5.583 |
| R-HSA-983189 | Kinesins | 2.760955e-06 | 5.559 |
| R-HSA-9612973 | Autophagy | 3.703580e-06 | 5.431 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.981877e-06 | 5.400 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.472727e-06 | 5.262 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.680207e-06 | 5.175 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.282383e-06 | 5.138 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 8.134544e-06 | 5.090 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 8.550446e-06 | 5.068 |
| R-HSA-5620924 | Intraflagellar transport | 1.160326e-05 | 4.935 |
| R-HSA-9833482 | PKR-mediated signaling | 1.451992e-05 | 4.838 |
| R-HSA-68877 | Mitotic Prometaphase | 2.017161e-05 | 4.695 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.519685e-05 | 4.599 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.860785e-05 | 4.544 |
| R-HSA-391251 | Protein folding | 3.688128e-05 | 4.433 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.963486e-05 | 4.402 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 4.972739e-05 | 4.303 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 5.455810e-05 | 4.263 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.998012e-05 | 4.222 |
| R-HSA-68886 | M Phase | 6.047090e-05 | 4.218 |
| R-HSA-1640170 | Cell Cycle | 7.453900e-05 | 4.128 |
| R-HSA-9609690 | HCMV Early Events | 1.296751e-04 | 3.887 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.486535e-04 | 3.828 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 1.524222e-04 | 3.817 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.756273e-04 | 3.323 |
| R-HSA-422475 | Axon guidance | 4.819603e-04 | 3.317 |
| R-HSA-69275 | G2/M Transition | 4.882167e-04 | 3.311 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.200370e-04 | 3.284 |
| R-HSA-5617833 | Cilium Assembly | 5.535189e-04 | 3.257 |
| R-HSA-9609646 | HCMV Infection | 6.734716e-04 | 3.172 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.868518e-04 | 3.163 |
| R-HSA-9675108 | Nervous system development | 8.888550e-04 | 3.051 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.079871e-03 | 2.967 |
| R-HSA-5358351 | Signaling by Hedgehog | 2.582601e-03 | 2.588 |
| R-HSA-913531 | Interferon Signaling | 3.105671e-03 | 2.508 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 3.594149e-03 | 2.444 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.324143e-03 | 2.364 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.065759e-03 | 2.295 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 5.867371e-03 | 2.232 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 6.885520e-03 | 2.162 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.192494e-03 | 2.143 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.053506e-02 | 1.977 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.106107e-02 | 1.956 |
| R-HSA-112316 | Neuronal System | 1.126288e-02 | 1.948 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 1.736089e-02 | 1.760 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 1.736089e-02 | 1.760 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.062697e-02 | 1.686 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.153608e-02 | 1.667 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.499555e-02 | 1.602 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.499555e-02 | 1.602 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.777503e-02 | 1.556 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 2.592877e-02 | 1.586 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.873665e-02 | 1.542 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.713561e-02 | 1.566 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.875425e-02 | 1.541 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 3.248652e-02 | 1.488 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.248652e-02 | 1.488 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.487312e-02 | 1.458 |
| R-HSA-380287 | Centrosome maturation | 3.705734e-02 | 1.431 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.821332e-02 | 1.418 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.821332e-02 | 1.418 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.028455e-02 | 1.299 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.028455e-02 | 1.299 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.070432e-02 | 1.295 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 4.429322e-02 | 1.354 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.070432e-02 | 1.295 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.772909e-02 | 1.321 |
| R-HSA-112303 | Electric Transmission Across Gap Junctions | 5.118988e-02 | 1.291 |
| R-HSA-112307 | Transmission across Electrical Synapses | 5.118988e-02 | 1.291 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.028455e-02 | 1.299 |
| R-HSA-5205647 | Mitophagy | 5.070432e-02 | 1.295 |
| R-HSA-9008059 | Interleukin-37 signaling | 4.020182e-02 | 1.396 |
| R-HSA-109582 | Hemostasis | 5.092387e-02 | 1.293 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.291131e-02 | 1.276 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.291131e-02 | 1.276 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.291131e-02 | 1.276 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 5.391735e-02 | 1.268 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.695827e-02 | 1.244 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.705971e-02 | 1.244 |
| R-HSA-74713 | IRS activation | 5.946485e-02 | 1.226 |
| R-HSA-8849472 | PTK6 Down-Regulation | 5.946485e-02 | 1.226 |
| R-HSA-8866376 | Reelin signalling pathway | 5.946485e-02 | 1.226 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.973152e-02 | 1.224 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 6.206889e-02 | 1.207 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.429792e-02 | 1.192 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 6.766815e-02 | 1.170 |
| R-HSA-112412 | SOS-mediated signalling | 8.386223e-02 | 1.076 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 1.076311e-01 | 0.968 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 8.181797e-02 | 1.087 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 9.771623e-02 | 1.010 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 7.457432e-02 | 1.127 |
| R-HSA-198203 | PI3K/AKT activation | 1.076311e-01 | 0.968 |
| R-HSA-190873 | Gap junction degradation | 9.977699e-02 | 1.001 |
| R-HSA-1221632 | Meiotic synapsis | 1.004456e-01 | 0.998 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 9.952984e-02 | 1.002 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 1.004456e-01 | 0.998 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 9.185423e-02 | 1.037 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 9.185423e-02 | 1.037 |
| R-HSA-196025 | Formation of annular gap junctions | 9.185423e-02 | 1.037 |
| R-HSA-74749 | Signal attenuation | 1.076311e-01 | 0.968 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 8.386223e-02 | 1.076 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 9.977699e-02 | 1.001 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 9.977699e-02 | 1.001 |
| R-HSA-9664873 | Pexophagy | 1.076311e-01 | 0.968 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.076311e-01 | 0.968 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 8.386223e-02 | 1.076 |
| R-HSA-9675135 | Diseases of DNA repair | 8.181797e-02 | 1.087 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.845147e-02 | 1.007 |
| R-HSA-8854214 | TBC/RABGAPs | 7.420351e-02 | 1.130 |
| R-HSA-2586552 | Signaling by Leptin | 1.076311e-01 | 0.968 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.680596e-02 | 1.061 |
| R-HSA-162582 | Signal Transduction | 1.080570e-01 | 0.966 |
| R-HSA-5693538 | Homology Directed Repair | 1.103403e-01 | 0.957 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 1.154172e-01 | 0.938 |
| R-HSA-186712 | Regulation of beta-cell development | 1.172466e-01 | 0.931 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.181125e-01 | 0.928 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 1.383731e-01 | 0.859 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 1.607373e-01 | 0.794 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.680632e-01 | 0.775 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 1.896621e-01 | 0.722 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.967373e-01 | 0.706 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.967373e-01 | 0.706 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.967373e-01 | 0.706 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.967373e-01 | 0.706 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.037511e-01 | 0.691 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.379185e-01 | 0.624 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.466262e-01 | 0.834 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 1.773102e-01 | 0.751 |
| R-HSA-72172 | mRNA Splicing | 1.346806e-01 | 0.871 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.383731e-01 | 0.859 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.835654e-01 | 0.736 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.680632e-01 | 0.775 |
| R-HSA-3928664 | Ephrin signaling | 1.825250e-01 | 0.739 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.680632e-01 | 0.775 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.232869e-01 | 0.909 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 1.406313e-01 | 0.852 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.231358e-01 | 0.910 |
| R-HSA-1268020 | Mitochondrial protein import | 1.258958e-01 | 0.900 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.533473e-01 | 0.814 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.025115e-01 | 0.694 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.307876e-01 | 0.883 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.496434e-01 | 0.825 |
| R-HSA-1500620 | Meiosis | 1.961690e-01 | 0.707 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 1.618330e-01 | 0.791 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 1.383731e-01 | 0.859 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.458928e-01 | 0.836 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.618330e-01 | 0.791 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.248774e-01 | 0.648 |
| R-HSA-9842663 | Signaling by LTK | 1.307876e-01 | 0.883 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.312035e-01 | 0.636 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.458928e-01 | 0.836 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 1.825250e-01 | 0.739 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 1.201125e-01 | 0.920 |
| R-HSA-428540 | Activation of RAC1 | 1.231358e-01 | 0.910 |
| R-HSA-877312 | Regulation of IFNG signaling | 1.307876e-01 | 0.883 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1.533473e-01 | 0.814 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.175968e-01 | 0.662 |
| R-HSA-9609507 | Protein localization | 1.897975e-01 | 0.722 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 2.175968e-01 | 0.662 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 1.258958e-01 | 0.900 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 1.825250e-01 | 0.739 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 2.107041e-01 | 0.676 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.920026e-01 | 0.717 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.680632e-01 | 0.775 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.107041e-01 | 0.676 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.248774e-01 | 0.648 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.175968e-01 | 0.662 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.854076e-01 | 0.732 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 2.107041e-01 | 0.676 |
| R-HSA-73887 | Death Receptor Signaling | 1.920026e-01 | 0.717 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.244298e-01 | 0.649 |
| R-HSA-1280218 | Adaptive Immune System | 2.254303e-01 | 0.647 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.379185e-01 | 0.624 |
| R-HSA-6806834 | Signaling by MET | 1.804336e-01 | 0.744 |
| R-HSA-2262752 | Cellular responses to stress | 1.241188e-01 | 0.906 |
| R-HSA-9824446 | Viral Infection Pathways | 2.063643e-01 | 0.685 |
| R-HSA-1266695 | Interleukin-7 signaling | 2.379185e-01 | 0.624 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.025115e-01 | 0.694 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.184645e-01 | 0.661 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.358028e-01 | 0.867 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.875991e-01 | 0.727 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.053659e-01 | 0.687 |
| R-HSA-73894 | DNA Repair | 2.409140e-01 | 0.618 |
| R-HSA-525793 | Myogenesis | 2.445752e-01 | 0.612 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.445752e-01 | 0.612 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 2.445752e-01 | 0.612 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.506489e-01 | 0.601 |
| R-HSA-3214847 | HATs acetylate histones | 2.506489e-01 | 0.601 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 2.511742e-01 | 0.600 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 2.511742e-01 | 0.600 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.575579e-01 | 0.589 |
| R-HSA-167287 | HIV elongation arrest and recovery | 2.577159e-01 | 0.589 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 2.577159e-01 | 0.589 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.577159e-01 | 0.589 |
| R-HSA-77387 | Insulin receptor recycling | 2.577159e-01 | 0.589 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.577159e-01 | 0.589 |
| R-HSA-1483255 | PI Metabolism | 2.603422e-01 | 0.584 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 2.642009e-01 | 0.578 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.668074e-01 | 0.574 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.668074e-01 | 0.574 |
| R-HSA-2424491 | DAP12 signaling | 2.706296e-01 | 0.568 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 2.706296e-01 | 0.568 |
| R-HSA-182971 | EGFR downregulation | 2.770026e-01 | 0.558 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.797359e-01 | 0.553 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.797359e-01 | 0.553 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.895831e-01 | 0.538 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.895831e-01 | 0.538 |
| R-HSA-354192 | Integrin signaling | 2.895831e-01 | 0.538 |
| R-HSA-390522 | Striated Muscle Contraction | 2.957917e-01 | 0.529 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.957917e-01 | 0.529 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.023159e-01 | 0.520 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.080223e-01 | 0.511 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.140958e-01 | 0.503 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.140958e-01 | 0.503 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.140958e-01 | 0.503 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 3.200916e-01 | 0.495 |
| R-HSA-68875 | Mitotic Prophase | 3.279712e-01 | 0.484 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.311622e-01 | 0.480 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 3.319274e-01 | 0.479 |
| R-HSA-201556 | Signaling by ALK | 3.319274e-01 | 0.479 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.319274e-01 | 0.479 |
| R-HSA-202433 | Generation of second messenger molecules | 3.377684e-01 | 0.471 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 3.377684e-01 | 0.471 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 3.377684e-01 | 0.471 |
| R-HSA-167169 | HIV Transcription Elongation | 3.377684e-01 | 0.471 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.435587e-01 | 0.464 |
| R-HSA-8951664 | Neddylation | 3.533499e-01 | 0.452 |
| R-HSA-69481 | G2/M Checkpoints | 3.533739e-01 | 0.452 |
| R-HSA-114608 | Platelet degranulation | 3.533739e-01 | 0.452 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.535189e-01 | 0.452 |
| R-HSA-165159 | MTOR signalling | 3.549889e-01 | 0.450 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.565272e-01 | 0.448 |
| R-HSA-1266738 | Developmental Biology | 3.613849e-01 | 0.442 |
| R-HSA-1474165 | Reproduction | 3.659541e-01 | 0.437 |
| R-HSA-2172127 | DAP12 interactions | 3.662214e-01 | 0.436 |
| R-HSA-69236 | G1 Phase | 3.662214e-01 | 0.436 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.662214e-01 | 0.436 |
| R-HSA-774815 | Nucleosome assembly | 3.717646e-01 | 0.430 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 3.717646e-01 | 0.430 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.717646e-01 | 0.430 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.717646e-01 | 0.430 |
| R-HSA-9909396 | Circadian clock | 3.722098e-01 | 0.429 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.753285e-01 | 0.426 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.772597e-01 | 0.423 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 3.772597e-01 | 0.423 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.772597e-01 | 0.423 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.772597e-01 | 0.423 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 3.827071e-01 | 0.417 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.827071e-01 | 0.417 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.842031e-01 | 0.415 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.881071e-01 | 0.411 |
| R-HSA-6807070 | PTEN Regulation | 3.969781e-01 | 0.401 |
| R-HSA-109704 | PI3K Cascade | 3.987668e-01 | 0.399 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 4.000436e-01 | 0.398 |
| R-HSA-9664417 | Leishmania phagocytosis | 4.000436e-01 | 0.398 |
| R-HSA-9664407 | Parasite infection | 4.000436e-01 | 0.398 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.031018e-01 | 0.395 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.040274e-01 | 0.394 |
| R-HSA-912446 | Meiotic recombination | 4.040274e-01 | 0.394 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.091963e-01 | 0.388 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.092422e-01 | 0.388 |
| R-HSA-72187 | mRNA 3'-end processing | 4.092422e-01 | 0.388 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.092422e-01 | 0.388 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.144117e-01 | 0.383 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.144117e-01 | 0.383 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.144117e-01 | 0.383 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.144117e-01 | 0.383 |
| R-HSA-4839726 | Chromatin organization | 4.193819e-01 | 0.377 |
| R-HSA-72649 | Translation initiation complex formation | 4.195363e-01 | 0.377 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.246164e-01 | 0.372 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.246164e-01 | 0.372 |
| R-HSA-166520 | Signaling by NTRKs | 4.272965e-01 | 0.369 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.296523e-01 | 0.367 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.296523e-01 | 0.367 |
| R-HSA-177929 | Signaling by EGFR | 4.296523e-01 | 0.367 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.296523e-01 | 0.367 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.296523e-01 | 0.367 |
| R-HSA-75893 | TNF signaling | 4.296523e-01 | 0.367 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.332663e-01 | 0.363 |
| R-HSA-112399 | IRS-mediated signalling | 4.346444e-01 | 0.362 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.346444e-01 | 0.362 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.392031e-01 | 0.357 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.395932e-01 | 0.357 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 4.493620e-01 | 0.347 |
| R-HSA-9610379 | HCMV Late Events | 4.538966e-01 | 0.343 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.541829e-01 | 0.343 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.541829e-01 | 0.343 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.589618e-01 | 0.338 |
| R-HSA-877300 | Interferon gamma signaling | 4.597130e-01 | 0.338 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.626078e-01 | 0.335 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.629593e-01 | 0.334 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.636991e-01 | 0.334 |
| R-HSA-8848021 | Signaling by PTK6 | 4.636991e-01 | 0.334 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.683953e-01 | 0.329 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.683953e-01 | 0.329 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.730507e-01 | 0.325 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.730507e-01 | 0.325 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.730507e-01 | 0.325 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.817537e-01 | 0.317 |
| R-HSA-168256 | Immune System | 4.863800e-01 | 0.313 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.867752e-01 | 0.313 |
| R-HSA-167172 | Transcription of the HIV genome | 4.867752e-01 | 0.313 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 4.867752e-01 | 0.313 |
| R-HSA-448424 | Interleukin-17 signaling | 4.957272e-01 | 0.305 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.001448e-01 | 0.301 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.001448e-01 | 0.301 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.001448e-01 | 0.301 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.001448e-01 | 0.301 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.045240e-01 | 0.297 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.049189e-01 | 0.297 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 5.088651e-01 | 0.293 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.174344e-01 | 0.286 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.174344e-01 | 0.286 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.223257e-01 | 0.282 |
| R-HSA-4086400 | PCP/CE pathway | 5.300107e-01 | 0.276 |
| R-HSA-9659379 | Sensory processing of sound | 5.341301e-01 | 0.272 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.382136e-01 | 0.269 |
| R-HSA-5663205 | Infectious disease | 5.391268e-01 | 0.268 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.419724e-01 | 0.266 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.541952e-01 | 0.256 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.581041e-01 | 0.253 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.581041e-01 | 0.253 |
| R-HSA-70268 | Pyruvate metabolism | 5.696276e-01 | 0.244 |
| R-HSA-74160 | Gene expression (Transcription) | 5.814904e-01 | 0.235 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.953684e-01 | 0.225 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 5.989187e-01 | 0.223 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.989187e-01 | 0.223 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.059267e-01 | 0.218 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.067706e-01 | 0.217 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.128131e-01 | 0.213 |
| R-HSA-422356 | Regulation of insulin secretion | 6.162114e-01 | 0.210 |
| R-HSA-190236 | Signaling by FGFR | 6.162114e-01 | 0.210 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.165490e-01 | 0.210 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.229193e-01 | 0.206 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.262295e-01 | 0.203 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.362970e-01 | 0.196 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.406836e-01 | 0.193 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.423525e-01 | 0.192 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.516928e-01 | 0.186 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.516928e-01 | 0.186 |
| R-HSA-202403 | TCR signaling | 6.577848e-01 | 0.182 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 6.637709e-01 | 0.178 |
| R-HSA-449147 | Signaling by Interleukins | 6.713982e-01 | 0.173 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.754330e-01 | 0.170 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 6.782852e-01 | 0.169 |
| R-HSA-909733 | Interferon alpha/beta signaling | 6.782852e-01 | 0.169 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.782852e-01 | 0.169 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 6.811125e-01 | 0.167 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 6.811125e-01 | 0.167 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 6.866933e-01 | 0.163 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 6.894473e-01 | 0.161 |
| R-HSA-73886 | Chromosome Maintenance | 6.948832e-01 | 0.158 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.002247e-01 | 0.155 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.080633e-01 | 0.150 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.080633e-01 | 0.150 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.080633e-01 | 0.150 |
| R-HSA-194138 | Signaling by VEGF | 7.080633e-01 | 0.150 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.108762e-01 | 0.148 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.206780e-01 | 0.142 |
| R-HSA-597592 | Post-translational protein modification | 7.208574e-01 | 0.142 |
| R-HSA-212436 | Generic Transcription Pathway | 7.330417e-01 | 0.135 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.397450e-01 | 0.131 |
| R-HSA-163685 | Integration of energy metabolism | 7.397450e-01 | 0.131 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.423240e-01 | 0.129 |
| R-HSA-9658195 | Leishmania infection | 7.423240e-01 | 0.129 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 7.553435e-01 | 0.122 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.553649e-01 | 0.122 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.638689e-01 | 0.117 |
| R-HSA-1483257 | Phospholipid metabolism | 7.647353e-01 | 0.116 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 7.662701e-01 | 0.116 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.680102e-01 | 0.115 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.720793e-01 | 0.112 |
| R-HSA-162587 | HIV Life Cycle | 7.857711e-01 | 0.105 |
| R-HSA-9711097 | Cellular response to starvation | 7.876592e-01 | 0.104 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.876592e-01 | 0.104 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.338329e-01 | 0.079 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.360863e-01 | 0.078 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.429016e-01 | 0.074 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.515881e-01 | 0.070 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.587728e-01 | 0.066 |
| R-HSA-397014 | Muscle contraction | 8.707748e-01 | 0.060 |
| R-HSA-8953854 | Metabolism of RNA | 8.744817e-01 | 0.058 |
| R-HSA-9679506 | SARS-CoV Infections | 8.834680e-01 | 0.054 |
| R-HSA-162906 | HIV Infection | 8.869046e-01 | 0.052 |
| R-HSA-1643685 | Disease | 8.895465e-01 | 0.051 |
| R-HSA-157118 | Signaling by NOTCH | 8.992561e-01 | 0.046 |
| R-HSA-5688426 | Deubiquitination | 9.118517e-01 | 0.040 |
| R-HSA-6798695 | Neutrophil degranulation | 9.241170e-01 | 0.034 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.307106e-01 | 0.031 |
| R-HSA-195721 | Signaling by WNT | 9.399340e-01 | 0.027 |
| R-HSA-392499 | Metabolism of proteins | 9.501360e-01 | 0.022 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.591126e-01 | 0.018 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.664301e-01 | 0.015 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.721969e-01 | 0.012 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.738915e-01 | 0.011 |
| R-HSA-168249 | Innate Immune System | 9.811879e-01 | 0.008 |
| R-HSA-72766 | Translation | 9.816176e-01 | 0.008 |
| R-HSA-382551 | Transport of small molecules | 9.998836e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999853e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999896e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.830 | 0.265 | 1 | 0.825 |
COT |
0.825 | 0.165 | 2 | 0.749 |
SRPK1 |
0.820 | 0.196 | -3 | 0.746 |
PIM3 |
0.818 | 0.156 | -3 | 0.800 |
HIPK4 |
0.818 | 0.201 | 1 | 0.809 |
NDR2 |
0.815 | 0.136 | -3 | 0.795 |
MOS |
0.815 | 0.147 | 1 | 0.829 |
PRKD1 |
0.813 | 0.190 | -3 | 0.788 |
MTOR |
0.812 | 0.110 | 1 | 0.750 |
CDKL5 |
0.811 | 0.164 | -3 | 0.774 |
CDC7 |
0.810 | 0.037 | 1 | 0.806 |
KIS |
0.809 | 0.141 | 1 | 0.722 |
GRK1 |
0.809 | 0.147 | -2 | 0.766 |
CDKL1 |
0.808 | 0.133 | -3 | 0.773 |
PRPK |
0.808 | 0.024 | -1 | 0.819 |
RSK2 |
0.807 | 0.123 | -3 | 0.752 |
FAM20C |
0.807 | 0.218 | 2 | 0.736 |
PIM1 |
0.806 | 0.142 | -3 | 0.747 |
IKKB |
0.806 | -0.010 | -2 | 0.711 |
CLK2 |
0.806 | 0.212 | -3 | 0.728 |
ERK5 |
0.805 | 0.135 | 1 | 0.859 |
SKMLCK |
0.805 | 0.132 | -2 | 0.813 |
PRKD2 |
0.804 | 0.117 | -3 | 0.735 |
CAMK2D |
0.804 | 0.121 | -3 | 0.767 |
DYRK2 |
0.803 | 0.163 | 1 | 0.751 |
NLK |
0.803 | 0.060 | 1 | 0.818 |
SRPK2 |
0.803 | 0.136 | -3 | 0.672 |
DSTYK |
0.802 | 0.004 | 2 | 0.806 |
ATR |
0.802 | 0.025 | 1 | 0.789 |
CAMK1B |
0.802 | 0.040 | -3 | 0.792 |
MST4 |
0.802 | 0.093 | 2 | 0.742 |
MARK4 |
0.801 | 0.099 | 4 | 0.755 |
CDK18 |
0.800 | 0.164 | 1 | 0.647 |
PDHK4 |
0.800 | -0.110 | 1 | 0.797 |
P90RSK |
0.800 | 0.105 | -3 | 0.758 |
CAMK2G |
0.800 | -0.012 | 2 | 0.772 |
ICK |
0.800 | 0.125 | -3 | 0.803 |
NDR1 |
0.799 | 0.044 | -3 | 0.778 |
CHAK2 |
0.799 | 0.052 | -1 | 0.775 |
BMPR2 |
0.799 | -0.051 | -2 | 0.831 |
CDK1 |
0.799 | 0.153 | 1 | 0.672 |
MAPKAPK2 |
0.798 | 0.106 | -3 | 0.706 |
RSK3 |
0.798 | 0.094 | -3 | 0.743 |
LATS2 |
0.798 | 0.070 | -5 | 0.732 |
WNK1 |
0.798 | 0.040 | -2 | 0.857 |
RAF1 |
0.798 | -0.070 | 1 | 0.792 |
SRPK3 |
0.797 | 0.113 | -3 | 0.709 |
HIPK2 |
0.797 | 0.165 | 1 | 0.671 |
BMPR1B |
0.796 | 0.124 | 1 | 0.780 |
CDK5 |
0.796 | 0.155 | 1 | 0.725 |
GCN2 |
0.796 | -0.142 | 2 | 0.678 |
PKN3 |
0.796 | 0.035 | -3 | 0.773 |
CDK3 |
0.796 | 0.200 | 1 | 0.620 |
CAMK2B |
0.796 | 0.107 | 2 | 0.793 |
TBK1 |
0.796 | -0.061 | 1 | 0.682 |
CAMK2A |
0.796 | 0.109 | 2 | 0.799 |
NUAK2 |
0.795 | 0.052 | -3 | 0.784 |
MAPKAPK3 |
0.795 | 0.060 | -3 | 0.732 |
LATS1 |
0.795 | 0.172 | -3 | 0.817 |
PKCD |
0.795 | 0.079 | 2 | 0.664 |
NIK |
0.794 | 0.002 | -3 | 0.789 |
GRK5 |
0.794 | -0.082 | -3 | 0.768 |
HIPK1 |
0.794 | 0.165 | 1 | 0.757 |
CAMLCK |
0.794 | 0.021 | -2 | 0.785 |
IKKE |
0.793 | -0.058 | 1 | 0.682 |
MLK1 |
0.793 | -0.052 | 2 | 0.693 |
PDHK1 |
0.793 | -0.131 | 1 | 0.788 |
AURC |
0.793 | 0.054 | -2 | 0.581 |
NEK6 |
0.793 | -0.027 | -2 | 0.812 |
IKKA |
0.793 | -0.002 | -2 | 0.699 |
ULK2 |
0.793 | -0.115 | 2 | 0.623 |
PKN2 |
0.792 | 0.035 | -3 | 0.762 |
DAPK2 |
0.792 | 0.028 | -3 | 0.798 |
CLK4 |
0.792 | 0.115 | -3 | 0.731 |
CDK8 |
0.792 | 0.071 | 1 | 0.691 |
CDK7 |
0.792 | 0.087 | 1 | 0.706 |
CDK19 |
0.792 | 0.088 | 1 | 0.661 |
RSK4 |
0.791 | 0.105 | -3 | 0.733 |
TGFBR2 |
0.790 | -0.051 | -2 | 0.728 |
BCKDK |
0.790 | -0.075 | -1 | 0.741 |
AMPKA1 |
0.789 | 0.027 | -3 | 0.785 |
PKACG |
0.789 | 0.026 | -2 | 0.695 |
PKCB |
0.789 | 0.086 | 2 | 0.620 |
CLK1 |
0.789 | 0.123 | -3 | 0.707 |
DYRK4 |
0.789 | 0.156 | 1 | 0.678 |
PKACB |
0.789 | 0.085 | -2 | 0.610 |
MLK2 |
0.789 | -0.007 | 2 | 0.688 |
TSSK2 |
0.789 | 0.047 | -5 | 0.826 |
P38B |
0.789 | 0.134 | 1 | 0.700 |
JNK2 |
0.789 | 0.135 | 1 | 0.658 |
PKCA |
0.789 | 0.081 | 2 | 0.613 |
QSK |
0.788 | 0.077 | 4 | 0.739 |
TSSK1 |
0.788 | 0.061 | -3 | 0.809 |
P70S6KB |
0.788 | 0.022 | -3 | 0.744 |
P38A |
0.787 | 0.115 | 1 | 0.754 |
GRK7 |
0.787 | 0.065 | 1 | 0.729 |
RIPK3 |
0.787 | -0.095 | 3 | 0.689 |
MLK3 |
0.787 | 0.000 | 2 | 0.645 |
CDK13 |
0.787 | 0.080 | 1 | 0.681 |
PRKX |
0.786 | 0.099 | -3 | 0.668 |
JNK3 |
0.786 | 0.117 | 1 | 0.685 |
PKCG |
0.786 | 0.051 | 2 | 0.629 |
MASTL |
0.786 | -0.118 | -2 | 0.799 |
PKR |
0.786 | 0.055 | 1 | 0.791 |
HUNK |
0.785 | -0.093 | 2 | 0.665 |
GRK6 |
0.785 | -0.063 | 1 | 0.787 |
NEK7 |
0.785 | -0.160 | -3 | 0.732 |
NIM1 |
0.785 | 0.020 | 3 | 0.722 |
AMPKA2 |
0.784 | 0.032 | -3 | 0.762 |
PRKD3 |
0.784 | 0.064 | -3 | 0.708 |
MSK1 |
0.784 | 0.062 | -3 | 0.725 |
CDK17 |
0.784 | 0.108 | 1 | 0.598 |
MSK2 |
0.784 | 0.032 | -3 | 0.724 |
TGFBR1 |
0.783 | 0.032 | -2 | 0.753 |
DNAPK |
0.783 | 0.083 | 1 | 0.681 |
AKT2 |
0.783 | 0.096 | -3 | 0.675 |
MAK |
0.783 | 0.206 | -2 | 0.650 |
P38G |
0.783 | 0.111 | 1 | 0.597 |
MNK2 |
0.783 | 0.017 | -2 | 0.729 |
ERK1 |
0.782 | 0.093 | 1 | 0.684 |
PIM2 |
0.782 | 0.092 | -3 | 0.715 |
MPSK1 |
0.782 | 0.179 | 1 | 0.763 |
HIPK3 |
0.782 | 0.122 | 1 | 0.748 |
DLK |
0.782 | -0.136 | 1 | 0.764 |
CDK12 |
0.782 | 0.087 | 1 | 0.656 |
ATM |
0.781 | -0.018 | 1 | 0.735 |
PAK1 |
0.781 | -0.017 | -2 | 0.721 |
IRE1 |
0.781 | -0.061 | 1 | 0.749 |
NEK9 |
0.780 | -0.125 | 2 | 0.683 |
CDK2 |
0.780 | 0.100 | 1 | 0.733 |
MARK3 |
0.780 | 0.048 | 4 | 0.684 |
GRK4 |
0.780 | -0.117 | -2 | 0.788 |
QIK |
0.780 | -0.020 | -3 | 0.754 |
SIK |
0.779 | 0.042 | -3 | 0.700 |
PRP4 |
0.779 | 0.094 | -3 | 0.726 |
ALK4 |
0.779 | -0.039 | -2 | 0.781 |
ANKRD3 |
0.779 | -0.146 | 1 | 0.791 |
DYRK1A |
0.779 | 0.105 | 1 | 0.747 |
PASK |
0.778 | 0.117 | -3 | 0.815 |
PKCZ |
0.778 | 0.013 | 2 | 0.634 |
TTBK2 |
0.778 | -0.135 | 2 | 0.572 |
SGK3 |
0.778 | 0.069 | -3 | 0.732 |
YSK4 |
0.778 | -0.042 | 1 | 0.715 |
ALK2 |
0.778 | 0.029 | -2 | 0.761 |
PKG2 |
0.778 | 0.032 | -2 | 0.615 |
TLK2 |
0.777 | -0.017 | 1 | 0.757 |
RIPK1 |
0.777 | -0.139 | 1 | 0.747 |
WNK3 |
0.777 | -0.227 | 1 | 0.755 |
VRK2 |
0.777 | -0.042 | 1 | 0.822 |
CDK14 |
0.777 | 0.106 | 1 | 0.682 |
MST3 |
0.777 | 0.092 | 2 | 0.718 |
MNK1 |
0.777 | 0.004 | -2 | 0.735 |
BRSK1 |
0.776 | 0.001 | -3 | 0.734 |
PAK3 |
0.776 | -0.050 | -2 | 0.724 |
SMG1 |
0.776 | -0.041 | 1 | 0.745 |
DYRK3 |
0.776 | 0.107 | 1 | 0.759 |
MARK2 |
0.776 | 0.026 | 4 | 0.660 |
CDK9 |
0.776 | 0.056 | 1 | 0.687 |
PHKG1 |
0.776 | -0.039 | -3 | 0.756 |
ULK1 |
0.776 | -0.208 | -3 | 0.700 |
CK1E |
0.775 | 0.022 | -3 | 0.515 |
P38D |
0.775 | 0.120 | 1 | 0.616 |
ACVR2B |
0.775 | -0.010 | -2 | 0.740 |
PKCH |
0.775 | -0.004 | 2 | 0.592 |
CHK1 |
0.775 | 0.018 | -3 | 0.762 |
MEK1 |
0.774 | -0.116 | 2 | 0.707 |
AURB |
0.774 | -0.014 | -2 | 0.581 |
CDK16 |
0.774 | 0.103 | 1 | 0.616 |
PAK6 |
0.773 | -0.004 | -2 | 0.631 |
DCAMKL1 |
0.773 | 0.049 | -3 | 0.735 |
MLK4 |
0.773 | -0.082 | 2 | 0.609 |
ACVR2A |
0.773 | -0.035 | -2 | 0.721 |
MELK |
0.773 | -0.036 | -3 | 0.741 |
MYLK4 |
0.773 | -0.009 | -2 | 0.706 |
DYRK1B |
0.773 | 0.095 | 1 | 0.691 |
CDK10 |
0.773 | 0.095 | 1 | 0.669 |
NUAK1 |
0.772 | -0.023 | -3 | 0.730 |
BRSK2 |
0.772 | -0.045 | -3 | 0.739 |
BMPR1A |
0.771 | 0.046 | 1 | 0.752 |
MOK |
0.771 | 0.160 | 1 | 0.799 |
CK1D |
0.770 | 0.029 | -3 | 0.466 |
ERK7 |
0.770 | 0.047 | 2 | 0.476 |
NEK2 |
0.770 | -0.098 | 2 | 0.660 |
IRE2 |
0.769 | -0.096 | 2 | 0.578 |
GSK3A |
0.769 | 0.040 | 4 | 0.403 |
CHAK1 |
0.769 | -0.116 | 2 | 0.622 |
PKACA |
0.769 | 0.050 | -2 | 0.559 |
CAMK4 |
0.768 | -0.130 | -3 | 0.740 |
AURA |
0.768 | -0.021 | -2 | 0.540 |
MARK1 |
0.768 | -0.013 | 4 | 0.700 |
ERK2 |
0.768 | 0.023 | 1 | 0.708 |
TAO3 |
0.767 | 0.026 | 1 | 0.733 |
PKCE |
0.767 | 0.065 | 2 | 0.612 |
CK1G1 |
0.767 | 0.003 | -3 | 0.506 |
WNK4 |
0.767 | -0.044 | -2 | 0.868 |
MEKK2 |
0.766 | -0.042 | 2 | 0.657 |
PKCT |
0.766 | 0.016 | 2 | 0.594 |
MAPKAPK5 |
0.766 | -0.047 | -3 | 0.680 |
PAK2 |
0.766 | -0.093 | -2 | 0.706 |
MEKK1 |
0.766 | -0.087 | 1 | 0.745 |
GRK2 |
0.766 | -0.073 | -2 | 0.670 |
PLK1 |
0.766 | -0.160 | -2 | 0.730 |
PERK |
0.765 | -0.130 | -2 | 0.781 |
GAK |
0.765 | 0.066 | 1 | 0.810 |
DRAK1 |
0.765 | -0.079 | 1 | 0.685 |
TNIK |
0.764 | 0.130 | 3 | 0.855 |
PLK4 |
0.764 | -0.069 | 2 | 0.468 |
MEKK3 |
0.764 | -0.114 | 1 | 0.742 |
AKT1 |
0.764 | 0.044 | -3 | 0.686 |
SSTK |
0.764 | -0.001 | 4 | 0.728 |
MEK5 |
0.764 | -0.172 | 2 | 0.679 |
ZAK |
0.764 | -0.104 | 1 | 0.707 |
NEK5 |
0.763 | -0.053 | 1 | 0.776 |
CAMK1G |
0.763 | -0.027 | -3 | 0.704 |
BUB1 |
0.763 | 0.135 | -5 | 0.804 |
GSK3B |
0.763 | -0.013 | 4 | 0.397 |
GCK |
0.763 | 0.077 | 1 | 0.760 |
JNK1 |
0.762 | 0.075 | 1 | 0.642 |
PLK3 |
0.762 | -0.131 | 2 | 0.695 |
CK1A2 |
0.762 | 0.000 | -3 | 0.467 |
BRAF |
0.761 | -0.113 | -4 | 0.700 |
SMMLCK |
0.761 | -0.031 | -3 | 0.758 |
PDK1 |
0.760 | 0.003 | 1 | 0.719 |
AKT3 |
0.760 | 0.079 | -3 | 0.635 |
PKCI |
0.760 | -0.010 | 2 | 0.605 |
TLK1 |
0.759 | -0.121 | -2 | 0.775 |
CDK6 |
0.759 | 0.077 | 1 | 0.662 |
HPK1 |
0.759 | 0.070 | 1 | 0.746 |
IRAK4 |
0.759 | -0.092 | 1 | 0.747 |
HGK |
0.759 | 0.051 | 3 | 0.837 |
DCAMKL2 |
0.758 | -0.039 | -3 | 0.745 |
MINK |
0.758 | 0.070 | 1 | 0.747 |
DAPK3 |
0.758 | 0.022 | -3 | 0.748 |
SGK1 |
0.758 | 0.084 | -3 | 0.618 |
HRI |
0.758 | -0.201 | -2 | 0.792 |
SNRK |
0.758 | -0.175 | 2 | 0.523 |
PINK1 |
0.758 | -0.171 | 1 | 0.803 |
KHS1 |
0.757 | 0.109 | 1 | 0.745 |
CAMK1D |
0.757 | 0.013 | -3 | 0.649 |
MEKK6 |
0.757 | 0.010 | 1 | 0.757 |
GRK3 |
0.757 | -0.054 | -2 | 0.634 |
KHS2 |
0.757 | 0.109 | 1 | 0.757 |
LKB1 |
0.756 | -0.026 | -3 | 0.728 |
EEF2K |
0.756 | 0.012 | 3 | 0.808 |
TAO2 |
0.755 | -0.058 | 2 | 0.713 |
CK2A2 |
0.755 | -0.001 | 1 | 0.661 |
P70S6K |
0.755 | -0.017 | -3 | 0.675 |
NEK11 |
0.755 | -0.110 | 1 | 0.724 |
SBK |
0.755 | 0.098 | -3 | 0.575 |
ROCK2 |
0.755 | 0.065 | -3 | 0.742 |
MST2 |
0.755 | -0.031 | 1 | 0.762 |
CDK4 |
0.754 | 0.059 | 1 | 0.647 |
PHKG2 |
0.754 | -0.077 | -3 | 0.721 |
TAK1 |
0.754 | -0.031 | 1 | 0.776 |
MAP3K15 |
0.754 | -0.001 | 1 | 0.695 |
CAMKK1 |
0.753 | -0.129 | -2 | 0.718 |
LRRK2 |
0.752 | -0.050 | 2 | 0.702 |
DAPK1 |
0.751 | 0.005 | -3 | 0.737 |
PKN1 |
0.751 | 0.004 | -3 | 0.687 |
CHK2 |
0.750 | 0.035 | -3 | 0.620 |
CAMKK2 |
0.750 | -0.120 | -2 | 0.711 |
NEK4 |
0.749 | -0.093 | 1 | 0.743 |
NEK8 |
0.749 | -0.184 | 2 | 0.669 |
MRCKB |
0.749 | 0.024 | -3 | 0.691 |
PBK |
0.749 | 0.048 | 1 | 0.750 |
PAK5 |
0.748 | -0.066 | -2 | 0.579 |
LOK |
0.747 | -0.050 | -2 | 0.734 |
CK2A1 |
0.747 | -0.010 | 1 | 0.635 |
PDHK3_TYR |
0.747 | 0.229 | 4 | 0.815 |
TTBK1 |
0.747 | -0.189 | 2 | 0.502 |
NEK1 |
0.746 | -0.054 | 1 | 0.744 |
VRK1 |
0.745 | -0.071 | 2 | 0.657 |
PAK4 |
0.744 | -0.058 | -2 | 0.570 |
DMPK1 |
0.744 | 0.053 | -3 | 0.710 |
YSK1 |
0.744 | -0.021 | 2 | 0.667 |
PLK2 |
0.743 | -0.066 | -3 | 0.682 |
MRCKA |
0.742 | -0.012 | -3 | 0.701 |
CAMK1A |
0.742 | 0.005 | -3 | 0.627 |
IRAK1 |
0.741 | -0.265 | -1 | 0.716 |
MST1 |
0.741 | -0.092 | 1 | 0.740 |
SLK |
0.741 | -0.077 | -2 | 0.684 |
HASPIN |
0.739 | 0.008 | -1 | 0.682 |
MAP2K4_TYR |
0.739 | 0.125 | -1 | 0.833 |
STK33 |
0.738 | -0.139 | 2 | 0.512 |
PKMYT1_TYR |
0.738 | 0.126 | 3 | 0.805 |
OSR1 |
0.738 | -0.029 | 2 | 0.651 |
MYO3B |
0.737 | 0.028 | 2 | 0.683 |
CRIK |
0.737 | 0.050 | -3 | 0.699 |
MAP2K6_TYR |
0.736 | 0.080 | -1 | 0.823 |
PDHK4_TYR |
0.736 | 0.072 | 2 | 0.782 |
BIKE |
0.736 | 0.039 | 1 | 0.710 |
LIMK2_TYR |
0.736 | 0.118 | -3 | 0.795 |
TESK1_TYR |
0.736 | 0.023 | 3 | 0.838 |
ROCK1 |
0.736 | 0.017 | -3 | 0.700 |
MEK2 |
0.735 | -0.194 | 2 | 0.648 |
CK1A |
0.735 | -0.008 | -3 | 0.385 |
NEK3 |
0.734 | -0.088 | 1 | 0.697 |
PKG1 |
0.734 | -0.022 | -2 | 0.548 |
BMPR2_TYR |
0.734 | 0.045 | -1 | 0.824 |
YANK3 |
0.732 | -0.050 | 2 | 0.364 |
EPHA6 |
0.732 | 0.098 | -1 | 0.786 |
MAP2K7_TYR |
0.731 | -0.064 | 2 | 0.741 |
TTK |
0.730 | -0.075 | -2 | 0.747 |
AAK1 |
0.730 | 0.098 | 1 | 0.627 |
PDHK1_TYR |
0.729 | -0.027 | -1 | 0.825 |
MYO3A |
0.729 | -0.018 | 1 | 0.734 |
ASK1 |
0.729 | -0.071 | 1 | 0.678 |
ABL2 |
0.726 | 0.078 | -1 | 0.751 |
PINK1_TYR |
0.725 | -0.141 | 1 | 0.778 |
EPHB4 |
0.725 | 0.029 | -1 | 0.759 |
TXK |
0.725 | 0.079 | 1 | 0.790 |
FGR |
0.724 | 0.032 | 1 | 0.816 |
ABL1 |
0.723 | 0.072 | -1 | 0.753 |
TAO1 |
0.723 | -0.078 | 1 | 0.659 |
RIPK2 |
0.722 | -0.299 | 1 | 0.656 |
LCK |
0.722 | 0.067 | -1 | 0.796 |
TNK2 |
0.721 | 0.039 | 3 | 0.699 |
LIMK1_TYR |
0.721 | -0.088 | 2 | 0.708 |
ALPHAK3 |
0.721 | -0.076 | -1 | 0.719 |
BLK |
0.721 | 0.090 | -1 | 0.797 |
RET |
0.720 | -0.096 | 1 | 0.749 |
JAK2 |
0.720 | -0.060 | 1 | 0.749 |
TYRO3 |
0.720 | -0.063 | 3 | 0.750 |
TYK2 |
0.720 | -0.100 | 1 | 0.753 |
YES1 |
0.719 | -0.010 | -1 | 0.823 |
HCK |
0.719 | 0.015 | -1 | 0.794 |
SRMS |
0.719 | 0.019 | 1 | 0.814 |
ROS1 |
0.719 | -0.052 | 3 | 0.722 |
EPHA4 |
0.718 | 0.005 | 2 | 0.718 |
ITK |
0.718 | 0.012 | -1 | 0.759 |
MST1R |
0.718 | -0.108 | 3 | 0.760 |
CSF1R |
0.717 | -0.062 | 3 | 0.741 |
FER |
0.716 | -0.069 | 1 | 0.836 |
FYN |
0.714 | 0.060 | -1 | 0.795 |
TNNI3K_TYR |
0.714 | 0.016 | 1 | 0.772 |
EPHB3 |
0.712 | -0.019 | -1 | 0.743 |
DDR1 |
0.711 | -0.149 | 4 | 0.718 |
EPHB1 |
0.710 | -0.065 | 1 | 0.806 |
JAK3 |
0.710 | -0.116 | 1 | 0.713 |
JAK1 |
0.710 | -0.027 | 1 | 0.687 |
MERTK |
0.709 | -0.033 | 3 | 0.711 |
EPHB2 |
0.709 | -0.031 | -1 | 0.733 |
BMX |
0.709 | -0.020 | -1 | 0.678 |
KIT |
0.708 | -0.097 | 3 | 0.734 |
TNK1 |
0.708 | -0.061 | 3 | 0.733 |
EPHA7 |
0.707 | -0.022 | 2 | 0.692 |
MET |
0.706 | -0.077 | 3 | 0.727 |
NEK10_TYR |
0.706 | -0.098 | 1 | 0.618 |
TEC |
0.705 | -0.051 | -1 | 0.707 |
FGFR2 |
0.705 | -0.142 | 3 | 0.720 |
LYN |
0.705 | -0.016 | 3 | 0.660 |
AXL |
0.705 | -0.089 | 3 | 0.708 |
STLK3 |
0.705 | -0.213 | 1 | 0.678 |
INSRR |
0.705 | -0.135 | 3 | 0.675 |
KDR |
0.705 | -0.122 | 3 | 0.700 |
WEE1_TYR |
0.705 | -0.081 | -1 | 0.704 |
CK1G3 |
0.705 | -0.042 | -3 | 0.342 |
BTK |
0.703 | -0.127 | -1 | 0.727 |
PTK2 |
0.703 | 0.036 | -1 | 0.744 |
EPHA3 |
0.703 | -0.080 | 2 | 0.676 |
FLT3 |
0.703 | -0.161 | 3 | 0.743 |
PDGFRB |
0.702 | -0.200 | 3 | 0.747 |
PTK2B |
0.702 | -0.013 | -1 | 0.741 |
PTK6 |
0.702 | -0.153 | -1 | 0.708 |
EPHA1 |
0.702 | -0.062 | 3 | 0.702 |
SRC |
0.702 | -0.008 | -1 | 0.799 |
TEK |
0.701 | -0.152 | 3 | 0.670 |
YANK2 |
0.700 | -0.076 | 2 | 0.389 |
FRK |
0.700 | -0.071 | -1 | 0.775 |
LTK |
0.700 | -0.107 | 3 | 0.681 |
FGFR1 |
0.699 | -0.170 | 3 | 0.696 |
EPHA8 |
0.698 | -0.040 | -1 | 0.743 |
EPHA5 |
0.698 | -0.040 | 2 | 0.703 |
SYK |
0.697 | 0.022 | -1 | 0.711 |
FLT1 |
0.697 | -0.137 | -1 | 0.753 |
ALK |
0.696 | -0.155 | 3 | 0.651 |
MATK |
0.696 | -0.094 | -1 | 0.674 |
ERBB2 |
0.696 | -0.156 | 1 | 0.702 |
PDGFRA |
0.694 | -0.246 | 3 | 0.751 |
FGFR3 |
0.694 | -0.157 | 3 | 0.690 |
NTRK1 |
0.693 | -0.205 | -1 | 0.743 |
CSK |
0.693 | -0.103 | 2 | 0.688 |
NTRK3 |
0.692 | -0.125 | -1 | 0.698 |
DDR2 |
0.692 | -0.070 | 3 | 0.662 |
EGFR |
0.692 | -0.079 | 1 | 0.611 |
CK1G2 |
0.689 | -0.039 | -3 | 0.424 |
INSR |
0.688 | -0.176 | 3 | 0.663 |
EPHA2 |
0.688 | -0.052 | -1 | 0.695 |
FGFR4 |
0.688 | -0.096 | -1 | 0.704 |
NTRK2 |
0.684 | -0.263 | 3 | 0.679 |
FLT4 |
0.684 | -0.243 | 3 | 0.688 |
ERBB4 |
0.683 | -0.046 | 1 | 0.650 |
ZAP70 |
0.681 | 0.003 | -1 | 0.648 |
IGF1R |
0.674 | -0.168 | 3 | 0.594 |
MUSK |
0.672 | -0.179 | 1 | 0.606 |
FES |
0.669 | -0.132 | -1 | 0.674 |