Motif 208 (n=158)

Position-wise Probabilities

Download
uniprot genes site source protein function
A0A1W2PP11 None S376 ochoa Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) None
A0AV96 RBM47 S540 ochoa RNA-binding protein 47 (RNA-binding motif protein 47) Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:27050523, PubMed:31358901). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:27050523, ECO:0000269|PubMed:30844405, ECO:0000269|PubMed:31358901, ECO:0000269|PubMed:34160127}.
A6NE02 BTBD17 S42 ochoa BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) None
E9PAV3 NACA S1487 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
O00192 ARVCF S602 ochoa Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}.
O00267 SUPT5H S812 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O14497 ARID1A S1602 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14523 C2CD2L S426 ochoa Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}.
O14827 RASGRF2 S854 ochoa Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
O14828 SCAMP3 S72 ochoa Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
O15530 PDPK1 S36 ochoa 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}.
O15534 PER1 S1007 ochoa Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}.
O43310 CTIF S245 ochoa CBP80/20-dependent translation initiation factor Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.
O43639 NCK2 S275 ochoa Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}.
O43639 NCK2 S277 ochoa Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}.
O75146 HIP1R S1027 ochoa Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
O75351 VPS4B S108 ochoa Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:16193069, ECO:0000269|PubMed:18606141}.
O75420 GIGYF1 S412 ochoa GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}.
O75533 SF3B1 S377 ochoa Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}.
O75914 PAK3 S220 ochoa Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}.
O76061 STC2 S250 ochoa Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
O94823 ATP10B S1371 ochoa Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}.
O95180 CACNA1H S44 ochoa Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.
O95278 EPM2A S25 psp Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:25538239, PubMed:25544560, PubMed:26231210). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:14722920, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). {ECO:0000250|UniProtKB:Q9WUA5, ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:16901901, ECO:0000269|PubMed:16971387, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:20453062, ECO:0000269|PubMed:22036712, ECO:0000269|PubMed:23624058, ECO:0000269|PubMed:23922729, ECO:0000269|PubMed:25538239, ECO:0000269|PubMed:25544560, ECO:0000269|PubMed:26231210}.; FUNCTION: [Isoform 2]: Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712). {ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}.; FUNCTION: [Isoform 7]: Has phosphatase activity (in vitro). {ECO:0000269|PubMed:22036712}.
O95503 CBX6 S246 ochoa Chromobox protein homolog 6 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}.
O95622 ADCY5 S155 ochoa Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}.
P00519 ABL1 S828 ochoa Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
P03372 ESR1 S46 psp Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}.
P04233 CD74 S45 psp HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}.
P06127 CD5 S454 ochoa T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}.
P07199 CENPB S168 ochoa Major centromere autoantigen B (Centromere protein B) (CENP-B) Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}.
P08237 PFKM S398 ochoa ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
P08833 IGFBP1 S83 psp Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}.
P0C7M8 CLEC2L S55 ochoa C-type lectin domain family 2 member L None
P16402 H1-3 S42 ochoa Histone H1.3 (Histone H1c) (Histone H1s-2) Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P17600 SYN1 S71 ochoa Synapsin-1 (Brain protein 4.1) (Synapsin I) Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}.
P18031 PTPN1 S365 ochoa Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P21333 FLNA S2048 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P21333 FLNA S2279 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P28290 ITPRID2 S1134 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P28715 ERCC5 S356 ochoa DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}.
P42166 TMPO S66 ochoa Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42684 ABL2 S866 ochoa Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.
P46013 MKI67 S2925 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46087 NOP2 S666 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P46089 GPR3 S237 psp G-protein coupled receptor 3 (ACCA orphan receptor) Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}.
P46379 BAG6 S985 ochoa Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.
P50502 ST13 S181 ochoa Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}.
P51531 SMARCA2 S591 ochoa SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P51532 SMARCA4 S613 ochoa|psp SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
P55011 SLC12A2 S77 ochoa|psp Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
P55011 SLC12A2 S79 ochoa Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
P61964 WDR5 S22 ochoa WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
P78559 MAP1A Y773 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q00536 CDK16 S65 ochoa|psp Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.
Q12770 SCAP S943 ochoa Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}.
Q13428 TCOF1 S475 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q14315 FLNC S1156 ochoa Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}.
Q14653 IRF3 S188 psp Interferon regulatory factor 3 (IRF-3) Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.
Q14676 MDC1 S376 ochoa|psp Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14761 PTPRCAP S178 ochoa Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) None
Q14766 LTBP1 S494 ochoa Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}.
Q15149 PLEC S647 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15274 QPRT S42 ochoa Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase) Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}.
Q16566 CAMK4 S189 ochoa Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}.
Q3T8J9 GON4L S1571 ochoa GON-4-like protein (GON-4 homolog) Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.
Q3YEC7 RABL6 S365 ochoa Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}.
Q5VST9 OBSCN S6868 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VT06 CEP350 S1274 ochoa Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}.
Q5VV41 ARHGEF16 S107 ochoa Rho guanine nucleotide exchange factor 16 (Ephexin-4) Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.
Q66K64 DCAF15 S314 ochoa DDB1- and CUL4-associated factor 15 Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}.
Q66K74 MAP1S S610 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q674R7 ATG9B S867 ochoa Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}.
Q69YH5 CDCA2 S960 ochoa Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Q6IAA8 LAMTOR1 S42 ochoa Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}.
Q6NUJ5 PWWP2B S291 ochoa PWWP domain-containing protein 2B Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}.
Q6P1R3 MSANTD2 S39 ochoa Myb/SANT-like DNA-binding domain-containing protein 2 None
Q6P4R8 NFRKB S1033 ochoa Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}.
Q6UB99 ANKRD11 Y1851 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6UUV7 CRTC3 S169 ochoa CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
Q6ZMQ8 AATK S520 ochoa Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}.
Q7KZI7 MARK2 S498 ochoa Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}.
Q7Z5K2 WAPL S305 psp Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}.
Q86YV0 RASAL3 S58 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q86YV5 PRAG1 S879 ochoa Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}.
Q8IVL1 NAV2 S2365 ochoa Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.
Q8IX01 SUGP2 S772 ochoa SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) May play a role in mRNA splicing. {ECO:0000305}.
Q8IZP2 ST13P4 S177 ochoa Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) None
Q8N3E9 PLCD3 S559 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}.
Q8NBR6 MINDY2 S26 ochoa Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.
Q8ND56 LSM14A S219 ochoa Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.
Q8NFH5 NUP35 S25 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NI35 PATJ S351 ochoa InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.
Q8TAQ2 SMARCC2 S745 ochoa SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q8TBA6 GOLGA5 S88 ochoa Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
Q8TBC5 ZSCAN18 S345 ochoa Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) May be involved in transcriptional regulation.
Q8TD08 MAPK15 S379 psp Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
Q8TEK3 DOT1L S1243 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8TER5 ARHGEF40 S1491 ochoa Rho guanine nucleotide exchange factor 40 (Protein SOLO) May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8TF44 C2CD4C S74 ochoa C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) None
Q8TF71 SLC16A10 S36 ochoa Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}.
Q8WZ73 RFFL S35 ochoa E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}.
Q96A59 MARVELD3 S113 ochoa MARVEL domain-containing protein 3 As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}.
Q96L91 EP400 S2086 ochoa E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q9BQI7 PSD2 S191 ochoa PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) None
Q9BT25 HAUS8 S357 ochoa HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Q9BTC0 DIDO1 S500 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BTK6 PAGR1 S26 ochoa PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}.
Q9BTU6 PI4K2A S22 ochoa Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}.
Q9BWH6 RPAP1 S200 ochoa RNA polymerase II-associated protein 1 Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}.
Q9BYB0 SHANK3 S366 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BYB0 SHANK3 S1539 ochoa SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}.
Q9BZL4 PPP1R12C S602 ochoa Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}.
Q9BZS1 FOXP3 S274 psp Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}.
Q9C0J8 WDR33 S266 ochoa pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}.
Q9H1A4 ANAPC1 S529 ochoa Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9H1B7 IRF2BPL S519 ochoa Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}.
Q9H211 CDT1 S411 ochoa|psp DNA replication factor Cdt1 (Double parked homolog) (DUP) Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}.
Q9H4L5 OSBPL3 S265 ochoa Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}.
Q9H4Z2 ZNF335 S991 ochoa Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}.
Q9H5N1 RABEP2 S200 ochoa Rab GTPase-binding effector protein 2 (Rabaptin-5beta) Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}.
Q9H814 PHAX S39 ochoa Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}.
Q9H9H5 MAP6D1 S167 ochoa MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) May have microtubule-stabilizing activity. {ECO:0000250}.
Q9HC52 CBX8 S256 ochoa Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.
Q9NR30 DDX21 S592 ochoa Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}.
Q9NR33 POLE4 S32 ochoa DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}.
Q9NSY1 BMP2K S392 ochoa BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.
Q9NSY1 BMP2K S1135 ochoa BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}.
Q9NZ56 FMN2 S317 ochoa Formin-2 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.
Q9NZM4 BICRA S1413 ochoa BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}.
Q9P206 NHSL3 S529 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P266 JCAD S696 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9P273 TENM3 S111 ochoa Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}.
Q9UJ90 KCNE5 S95 ochoa Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein) Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.
Q9UJD0 RIMS3 S22 ochoa Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) Regulates synaptic membrane exocytosis. {ECO:0000250}.
Q9UNZ2 NSFL1C S140 ochoa|psp NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPA5 BSN S2899 ochoa Protein bassoon (Zinc finger protein 231) Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}.
Q9UPN4 CEP131 S417 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UPU5 USP24 S2551 ochoa Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.
Q9UQB3 CTNND2 S461 ochoa Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}.
Q9Y261 FOXA2 S307 ochoa Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.
Q9Y3Q8 TSC22D4 S279 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y4H2 IRS2 S406 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
R4GMW8 BIVM-ERCC5 S810 ochoa DNA excision repair protein ERCC-5 None
P34932 HSPA4 S31 Sugiyama Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
P34932 HSPA4 S40 Sugiyama Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
Q13155 AIMP2 S51 Sugiyama Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}.
Q8NFI4 ST13P5 S181 Sugiyama Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) None
P05187 ALPP S192 Sugiyama Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.
P10696 ALPG S189 Sugiyama Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}.
P42167 TMPO S66 Sugiyama Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P09923 ALPI S189 Sugiyama Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}.
P14866 HNRNPL S471 Sugiyama Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}.
Q96EP5 DAZAP1 S195 Sugiyama DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) RNA-binding protein, which may be required during spermatogenesis.
O43175 PHGDH S280 Sugiyama D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}.
P51452 DUSP3 S43 Sugiyama Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.
Q8TD08 MAPK15 S447 Sugiyama Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
P14598 NCF1 S288 SIGNOR|EPSD|PSP Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}.
Download
reactome_id name p -log10_p
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.000005 5.341
R-HSA-9932451 SWI/SNF chromatin remodelers 0.000023 4.633
R-HSA-9932444 ATP-dependent chromatin remodelers 0.000023 4.633
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.000037 4.431
R-HSA-8878171 Transcriptional regulation by RUNX1 0.000074 4.128
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.000162 3.789
R-HSA-3214858 RMTs methylate histone arginines 0.000259 3.587
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.000994 3.003
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.000994 3.003
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.001160 2.936
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.002609 2.584
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.002437 2.613
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.004264 2.370
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.004264 2.370
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.005228 2.282
R-HSA-193648 NRAGE signals death through JNK 0.005072 2.295
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.005012 2.300
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.006258 2.204
R-HSA-9006925 Intracellular signaling by second messengers 0.005647 2.248
R-HSA-74160 Gene expression (Transcription) 0.006178 2.209
R-HSA-4839726 Chromatin organization 0.008484 2.071
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.008654 2.063
R-HSA-73857 RNA Polymerase II Transcription 0.008014 2.096
R-HSA-212436 Generic Transcription Pathway 0.008726 2.059
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.009564 2.019
R-HSA-428540 Activation of RAC1 0.011363 1.945
R-HSA-212165 Epigenetic regulation of gene expression 0.011576 1.936
R-HSA-9855142 Cellular responses to mechanical stimuli 0.011581 1.936
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.011339 1.945
R-HSA-9796292 Formation of axial mesoderm 0.014395 1.842
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.014395 1.842
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.014395 1.842
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.012705 1.896
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.013839 1.859
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.013900 1.857
R-HSA-416482 G alpha (12/13) signalling events 0.013839 1.859
R-HSA-194138 Signaling by VEGF 0.017453 1.758
R-HSA-446353 Cell-extracellular matrix interactions 0.017735 1.751
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.051719 1.286
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.051719 1.286
R-HSA-74713 IRS activation 0.071653 1.145
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.071653 1.145
R-HSA-9027283 Erythropoietin activates STAT5 0.091172 1.040
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.100777 0.997
R-HSA-2470946 Cohesin Loading onto Chromatin 0.100777 0.997
R-HSA-112412 SOS-mediated signalling 0.100777 0.997
R-HSA-446107 Type I hemidesmosome assembly 0.110282 0.957
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.110282 0.957
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 0.119686 0.922
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.128992 0.889
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 0.128992 0.889
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.147312 0.832
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.156327 0.806
R-HSA-170660 Adenylate cyclase activating pathway 0.165248 0.782
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 0.062310 1.205
R-HSA-9027284 Erythropoietin activates RAS 0.182809 0.738
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.182809 0.738
R-HSA-170670 Adenylate cyclase inhibitory pathway 0.182809 0.738
R-HSA-176412 Phosphorylation of the APC/C 0.191452 0.718
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.191452 0.718
R-HSA-5696400 Dual Incision in GG-NER 0.071080 1.148
R-HSA-77595 Processing of Intronless Pre-mRNAs 0.200003 0.699
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.086511 1.063
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.216837 0.664
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.089709 1.047
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.225122 0.648
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.225122 0.648
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.099505 1.002
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.241430 0.617
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.249456 0.603
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.249456 0.603
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.066349 1.178
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.137640 0.861
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.295869 0.529
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.295869 0.529
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.035942 1.444
R-HSA-167287 HIV elongation arrest and recovery 0.303322 0.518
R-HSA-167290 Pausing and recovery of HIV elongation 0.303322 0.518
R-HSA-9006335 Signaling by Erythropoietin 0.310697 0.508
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.174568 0.758
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.174568 0.758
R-HSA-8957275 Post-translational protein phosphorylation 0.110822 0.955
R-HSA-8854518 AURKA Activation by TPX2 0.185941 0.731
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.212844 0.672
R-HSA-380287 Centrosome maturation 0.220602 0.656
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.275329 0.560
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.247911 0.606
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.283160 0.548
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.074088 1.130
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.276229 0.559
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.187254 0.728
R-HSA-198203 PI3K/AKT activation 0.128992 0.889
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.187254 0.728
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.187254 0.728
R-HSA-8939211 ESR-mediated signaling 0.291849 0.535
R-HSA-5576890 Phase 3 - rapid repolarisation 0.100777 0.997
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.021369 1.670
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.156327 0.806
R-HSA-6782135 Dual incision in TC-NER 0.155891 0.807
R-HSA-1606341 IRF3 mediated activation of type 1 IFN 0.071653 1.145
R-HSA-165158 Activation of AKT2 0.071653 1.145
R-HSA-8849472 PTK6 Down-Regulation 0.071653 1.145
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.208465 0.681
R-HSA-112399 IRS-mediated signalling 0.152203 0.818
R-HSA-113418 Formation of the Early Elongation Complex 0.303322 0.518
R-HSA-2428928 IRS-related events triggered by IGF1R 0.167052 0.777
R-HSA-3928664 Ephrin signaling 0.025284 1.597
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.200003 0.699
R-HSA-72086 mRNA Capping 0.310697 0.508
R-HSA-9734767 Developmental Cell Lineages 0.032434 1.489
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.159595 0.797
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 0.110282 0.957
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.303322 0.518
R-HSA-9009391 Extra-nuclear estrogen signaling 0.032313 1.491
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.126868 0.897
R-HSA-5619507 Activation of HOX genes during differentiation 0.126868 0.897
R-HSA-68962 Activation of the pre-replicative complex 0.056687 1.247
R-HSA-8985801 Regulation of cortical dendrite branching 0.041592 1.381
R-HSA-68952 DNA replication initiation 0.128992 0.889
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.147312 0.832
R-HSA-202670 ERKs are inactivated 0.147312 0.832
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.182809 0.738
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.071080 1.148
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.200003 0.699
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.216837 0.664
R-HSA-164378 PKA activation in glucagon signalling 0.216837 0.664
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.025611 1.592
R-HSA-109704 PI3K Cascade 0.126936 0.896
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.273031 0.564
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.273031 0.564
R-HSA-5693606 DNA Double Strand Break Response 0.189755 0.722
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.208975 0.680
R-HSA-74751 Insulin receptor signalling cascade 0.178347 0.749
R-HSA-2428924 IGF1R signaling cascade 0.178347 0.749
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.092941 1.032
R-HSA-9823730 Formation of definitive endoderm 0.029466 1.531
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.128992 0.889
R-HSA-74749 Signal attenuation 0.128992 0.889
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.065190 1.186
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.233319 0.632
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.205113 0.688
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.182138 0.740
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.220602 0.656
R-HSA-5696398 Nucleotide Excision Repair 0.129226 0.889
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 0.182809 0.738
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.257398 0.589
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.075585 1.122
R-HSA-112040 G-protein mediated events 0.189755 0.722
R-HSA-74752 Signaling by Insulin receptor 0.095634 1.019
R-HSA-162599 Late Phase of HIV Life Cycle 0.242129 0.616
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.216837 0.664
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.119892 0.921
R-HSA-9675151 Disorders of Developmental Biology 0.021369 1.670
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.128992 0.889
R-HSA-5576893 Phase 2 - plateau phase 0.200003 0.699
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.200003 0.699
R-HSA-420029 Tight junction interactions 0.280724 0.552
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.295869 0.529
R-HSA-194441 Metabolism of non-coding RNA 0.159595 0.797
R-HSA-191859 snRNP Assembly 0.159595 0.797
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.255741 0.592
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.288337 0.540
R-HSA-69002 DNA Replication Pre-Initiation 0.138809 0.858
R-HSA-2980766 Nuclear Envelope Breakdown 0.152203 0.818
R-HSA-111933 Calmodulin induced events 0.077137 1.113
R-HSA-6811438 Intra-Golgi traffic 0.096207 1.017
R-HSA-69052 Switching of origins to a post-replicative state 0.212844 0.672
R-HSA-111997 CaM pathway 0.077137 1.113
R-HSA-525793 Myogenesis 0.288337 0.540
R-HSA-68882 Mitotic Anaphase 0.242944 0.614
R-HSA-5693532 DNA Double-Strand Break Repair 0.273366 0.563
R-HSA-3214841 PKMTs methylate histone lysines 0.092941 1.032
R-HSA-3322077 Glycogen synthesis 0.233319 0.632
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.267494 0.573
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.245231 0.610
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.147312 0.832
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.200003 0.699
R-HSA-8943724 Regulation of PTEN gene transcription 0.036543 1.437
R-HSA-1834941 STING mediated induction of host immune responses 0.225122 0.648
R-HSA-68886 M Phase 0.258406 0.588
R-HSA-111996 Ca-dependent events 0.099505 1.002
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.061739 1.209
R-HSA-426117 Cation-coupled Chloride cotransporters 0.100777 0.997
R-HSA-444257 RSK activation 0.110282 0.957
R-HSA-877312 Regulation of IFNG signaling 0.156327 0.806
R-HSA-163615 PKA activation 0.216837 0.664
R-HSA-1489509 DAG and IP3 signaling 0.109583 0.960
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.249456 0.603
R-HSA-166208 mTORC1-mediated signalling 0.257398 0.589
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.265256 0.576
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.310697 0.508
R-HSA-162587 HIV Life Cycle 0.284837 0.545
R-HSA-438064 Post NMDA receptor activation events 0.083360 1.079
R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 0.200003 0.699
R-HSA-5656169 Termination of translesion DNA synthesis 0.310697 0.508
R-HSA-112043 PLC beta mediated events 0.167052 0.777
R-HSA-68867 Assembly of the pre-replicative complex 0.298799 0.525
R-HSA-69278 Cell Cycle, Mitotic 0.096973 1.013
R-HSA-389356 Co-stimulation by CD28 0.119918 0.921
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.071653 1.145
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.156327 0.806
R-HSA-9697154 Disorders of Nervous System Development 0.156327 0.806
R-HSA-9005895 Pervasive developmental disorders 0.156327 0.806
R-HSA-3229121 Glycogen storage diseases 0.208465 0.681
R-HSA-912694 Regulation of IFNA/IFNB signaling 0.257398 0.589
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.265256 0.576
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.265256 0.576
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.288337 0.540
R-HSA-9841251 Mitochondrial unfolded protein response (UPRmt) 0.295869 0.529
R-HSA-1169408 ISG15 antiviral mechanism 0.220602 0.656
R-HSA-9909396 Circadian clock 0.074064 1.130
R-HSA-69306 DNA Replication 0.273366 0.563
R-HSA-3371556 Cellular response to heat stress 0.174088 0.759
R-HSA-1640170 Cell Cycle 0.089245 1.049
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 0.021369 1.670
R-HSA-140342 Apoptosis induced DNA fragmentation 0.128992 0.889
R-HSA-389359 CD28 dependent Vav1 pathway 0.165248 0.782
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.216837 0.664
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.288337 0.540
R-HSA-77387 Insulin receptor recycling 0.303322 0.518
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.170803 0.768
R-HSA-3247509 Chromatin modifying enzymes 0.019533 1.709
R-HSA-373753 Nephrin family interactions 0.233319 0.632
R-HSA-376176 Signaling by ROBO receptors 0.211503 0.675
R-HSA-69239 Synthesis of DNA 0.133988 0.873
R-HSA-69242 S Phase 0.101795 0.992
R-HSA-982772 Growth hormone receptor signaling 0.038579 1.414
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.051254 1.290
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.182809 0.738
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.241430 0.617
R-HSA-198753 ERK/MAPK targets 0.241430 0.617
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.249456 0.603
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.059309 1.227
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.193581 0.713
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.153618 0.814
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.119892 0.921
R-HSA-9860931 Response of endothelial cells to shear stress 0.035067 1.455
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.233847 0.631
R-HSA-2559583 Cellular Senescence 0.062266 1.206
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.074088 1.130
R-HSA-877300 Interferon gamma signaling 0.290589 0.537
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.240090 0.620
R-HSA-977347 Serine metabolism 0.249456 0.603
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.240090 0.620
R-HSA-2682334 EPH-Ephrin signaling 0.294893 0.530
R-HSA-909733 Interferon alpha/beta signaling 0.158661 0.800
R-HSA-9705683 SARS-CoV-2-host interactions 0.270686 0.568
R-HSA-9842860 Regulation of endogenous retroelements 0.033216 1.479
R-HSA-69206 G1/S Transition 0.187254 0.728
R-HSA-112315 Transmission across Chemical Synapses 0.300929 0.522
R-HSA-1257604 PIP3 activates AKT signaling 0.020047 1.698
R-HSA-430116 GP1b-IX-V activation signalling 0.119686 0.922
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.265256 0.576
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.051150 1.291
R-HSA-2586552 Signaling by Leptin 0.128992 0.889
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.119686 0.922
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.069870 1.156
R-HSA-381042 PERK regulates gene expression 0.074088 1.130
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.225122 0.648
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.273031 0.564
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.288337 0.540
R-HSA-1500931 Cell-Cell communication 0.027973 1.553
R-HSA-446728 Cell junction organization 0.040941 1.388
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.151115 0.821
R-HSA-354192 Integrin signaling 0.065190 1.186
R-HSA-9706369 Negative regulation of FLT3 0.191452 0.718
R-HSA-6807004 Negative regulation of MET activity 0.233319 0.632
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.280724 0.552
R-HSA-210745 Regulation of gene expression in beta cells 0.310697 0.508
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.098504 1.007
R-HSA-1266695 Interleukin-7 signaling 0.043487 1.362
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.046023 1.337
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.280724 0.552
R-HSA-9659379 Sensory processing of sound 0.236184 0.627
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.109583 0.960
R-HSA-5693538 Homology Directed Repair 0.166321 0.779
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.233541 0.632
R-HSA-69205 G1/S-Specific Transcription 0.077137 1.113
R-HSA-6807070 PTEN Regulation 0.230922 0.637
R-HSA-8983711 OAS antiviral response 0.156327 0.806
R-HSA-6804757 Regulation of TP53 Degradation 0.077137 1.113
R-HSA-8953897 Cellular responses to stimuli 0.041820 1.379
R-HSA-8986944 Transcriptional Regulation by MECP2 0.091464 1.039
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.310697 0.508
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.243999 0.613
R-HSA-2262752 Cellular responses to stress 0.215578 0.666
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.096207 1.017
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.086511 1.063
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.276229 0.559
R-HSA-75153 Apoptotic execution phase 0.113001 0.947
R-HSA-8853659 RET signaling 0.077137 1.113
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.303322 0.518
R-HSA-9856651 MITF-M-dependent gene expression 0.105137 0.978
R-HSA-9730414 MITF-M-regulated melanocyte development 0.103942 0.983
R-HSA-3700989 Transcriptional Regulation by TP53 0.259739 0.585
R-HSA-193704 p75 NTR receptor-mediated signalling 0.030550 1.515
R-HSA-73887 Death Receptor Signaling 0.111968 0.951
R-HSA-9675108 Nervous system development 0.311477 0.507
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.317994 0.498
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.317994 0.498
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.317994 0.498
R-HSA-421270 Cell-cell junction organization 0.325172 0.488
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.325214 0.488
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.325214 0.488
R-HSA-162588 Budding and maturation of HIV virion 0.325214 0.488
R-HSA-2129379 Molecules associated with elastic fibres 0.325214 0.488
R-HSA-9833109 Evasion by RSV of host interferon responses 0.325214 0.488
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.325214 0.488
R-HSA-186763 Downstream signal transduction 0.325214 0.488
R-HSA-3214847 HATs acetylate histones 0.326024 0.487
R-HSA-9614085 FOXO-mediated transcription 0.326024 0.487
R-HSA-70171 Glycolysis 0.329893 0.482
R-HSA-9675126 Diseases of mitotic cell cycle 0.332359 0.478
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.332359 0.478
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.333905 0.476
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.333905 0.476
R-HSA-2559580 Oxidative Stress Induced Senescence 0.337613 0.472
R-HSA-1855170 IPs transport between nucleus and cytosol 0.339428 0.469
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.339428 0.469
R-HSA-9022692 Regulation of MECP2 expression and activity 0.339428 0.469
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.339428 0.469
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.339428 0.469
R-HSA-9733709 Cardiogenesis 0.339428 0.469
R-HSA-397795 G-protein beta:gamma signalling 0.339428 0.469
R-HSA-1266738 Developmental Biology 0.344937 0.462
R-HSA-111885 Opioid Signalling 0.345306 0.462
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.346422 0.460
R-HSA-163359 Glucagon signaling in metabolic regulation 0.346422 0.460
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.346422 0.460
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.346422 0.460
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.346422 0.460
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.349142 0.457
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.352971 0.452
R-HSA-180746 Nuclear import of Rev protein 0.353343 0.452
R-HSA-9692914 SARS-CoV-1-host interactions 0.356792 0.448
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.360192 0.443
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.364409 0.438
R-HSA-114604 GPVI-mediated activation cascade 0.366968 0.435
R-HSA-8941326 RUNX2 regulates bone development 0.366968 0.435
R-HSA-202403 TCR signaling 0.371992 0.429
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.371992 0.429
R-HSA-166166 MyD88-independent TLR4 cascade 0.371992 0.429
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.373672 0.428
R-HSA-933541 TRAF6 mediated IRF7 activation 0.373672 0.428
R-HSA-419037 NCAM1 interactions 0.373672 0.428
R-HSA-5689896 Ovarian tumor domain proteases 0.373672 0.428
R-HSA-73894 DNA Repair 0.378127 0.422
R-HSA-1483249 Inositol phosphate metabolism 0.379539 0.421
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.380306 0.420
R-HSA-1566948 Elastic fibre formation 0.380306 0.420
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.380306 0.420
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.386871 0.412
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.386871 0.412
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.386871 0.412
R-HSA-68877 Mitotic Prometaphase 0.391438 0.407
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.392299 0.406
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.393366 0.405
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.393366 0.405
R-HSA-167169 HIV Transcription Elongation 0.393366 0.405
R-HSA-177243 Interactions of Rev with host cellular proteins 0.393366 0.405
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.393366 0.405
R-HSA-1251985 Nuclear signaling by ERBB4 0.393366 0.405
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.393366 0.405
R-HSA-8982491 Glycogen metabolism 0.393366 0.405
R-HSA-202433 Generation of second messenger molecules 0.393366 0.405
R-HSA-422475 Axon guidance 0.395386 0.403
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.399793 0.398
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.399793 0.398
R-HSA-8853884 Transcriptional Regulation by VENTX 0.399793 0.398
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.399793 0.398
R-HSA-9607240 FLT3 Signaling 0.399793 0.398
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.399982 0.398
R-HSA-70326 Glucose metabolism 0.405646 0.392
R-HSA-1592230 Mitochondrial biogenesis 0.405646 0.392
R-HSA-9932298 Degradation of CRY and PER proteins 0.406152 0.391
R-HSA-991365 Activation of GABAB receptors 0.412444 0.385
R-HSA-977444 GABA B receptor activation 0.412444 0.385
R-HSA-165159 MTOR signalling 0.412444 0.385
R-HSA-379716 Cytosolic tRNA aminoacylation 0.412444 0.385
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.412444 0.385
R-HSA-8878166 Transcriptional regulation by RUNX2 0.413010 0.384
R-HSA-68875 Mitotic Prophase 0.416675 0.380
R-HSA-112316 Neuronal System 0.418331 0.378
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.418669 0.378
R-HSA-69231 Cyclin D associated events in G1 0.424829 0.372
R-HSA-69236 G1 Phase 0.424829 0.372
R-HSA-913531 Interferon Signaling 0.428362 0.368
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.430925 0.366
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.430925 0.366
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.430925 0.366
R-HSA-72165 mRNA Splicing - Minor Pathway 0.436956 0.360
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.436956 0.360
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.436956 0.360
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.442923 0.354
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.448828 0.348
R-HSA-9634597 GPER1 signaling 0.448828 0.348
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.449129 0.348
R-HSA-73893 DNA Damage Bypass 0.454670 0.342
R-HSA-5658442 Regulation of RAS by GAPs 0.460451 0.337
R-HSA-418990 Adherens junctions interactions 0.464185 0.333
R-HSA-72187 mRNA 3'-end processing 0.471831 0.326
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.471831 0.326
R-HSA-112382 Formation of RNA Pol II elongation complex 0.471831 0.326
R-HSA-68949 Orc1 removal from chromatin 0.471831 0.326
R-HSA-6794361 Neurexins and neuroligins 0.471831 0.326
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.471831 0.326
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.477431 0.321
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.477431 0.321
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.477431 0.321
R-HSA-9639288 Amino acids regulate mTORC1 0.477431 0.321
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.477431 0.321
R-HSA-1221632 Meiotic synapsis 0.477431 0.321
R-HSA-445355 Smooth Muscle Contraction 0.477431 0.321
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.482972 0.316
R-HSA-1852241 Organelle biogenesis and maintenance 0.488396 0.311
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.488454 0.311
R-HSA-418597 G alpha (z) signalling events 0.488454 0.311
R-HSA-162906 HIV Infection 0.488513 0.311
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.493879 0.306
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.493879 0.306
R-HSA-8935690 Digestion 0.493879 0.306
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.493879 0.306
R-HSA-381119 Unfolded Protein Response (UPR) 0.494162 0.306
R-HSA-1483166 Synthesis of PA 0.499246 0.302
R-HSA-1632852 Macroautophagy 0.500883 0.300
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.504557 0.297
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.507548 0.295
R-HSA-186712 Regulation of beta-cell development 0.509812 0.293
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.509812 0.293
R-HSA-352230 Amino acid transport across the plasma membrane 0.509812 0.293
R-HSA-977443 GABA receptor activation 0.515012 0.288
R-HSA-379724 tRNA Aminoacylation 0.515012 0.288
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.515012 0.288
R-HSA-73856 RNA Polymerase II Transcription Termination 0.520156 0.284
R-HSA-168325 Viral Messenger RNA Synthesis 0.520156 0.284
R-HSA-445717 Aquaporin-mediated transport 0.520156 0.284
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.520156 0.284
R-HSA-450294 MAP kinase activation 0.520156 0.284
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.525247 0.280
R-HSA-6784531 tRNA processing in the nucleus 0.525247 0.280
R-HSA-375165 NCAM signaling for neurite out-growth 0.525247 0.280
R-HSA-9707616 Heme signaling 0.525247 0.280
R-HSA-186797 Signaling by PDGF 0.525247 0.280
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.525247 0.280
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.527192 0.278
R-HSA-166520 Signaling by NTRKs 0.527192 0.278
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.530283 0.275
R-HSA-373755 Semaphorin interactions 0.530283 0.275
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.530283 0.275
R-HSA-8848021 Signaling by PTK6 0.530283 0.275
R-HSA-8963743 Digestion and absorption 0.530283 0.275
R-HSA-9758941 Gastrulation 0.530414 0.275
R-HSA-936837 Ion transport by P-type ATPases 0.535267 0.271
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.545077 0.264
R-HSA-5683057 MAPK family signaling cascades 0.548270 0.261
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.549905 0.260
R-HSA-196807 Nicotinate metabolism 0.549905 0.260
R-HSA-9958863 SLC-mediated transport of amino acids 0.549905 0.260
R-HSA-9612973 Autophagy 0.552555 0.258
R-HSA-9694516 SARS-CoV-2 Infection 0.552563 0.258
R-HSA-167172 Transcription of the HIV genome 0.554681 0.256
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.554681 0.256
R-HSA-5688426 Deubiquitination 0.560533 0.251
R-HSA-388841 Regulation of T cell activation by CD28 family 0.562992 0.249
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.564084 0.249
R-HSA-448424 Interleukin-17 signaling 0.564084 0.249
R-HSA-5633007 Regulation of TP53 Activity 0.564874 0.248
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.568711 0.245
R-HSA-453276 Regulation of mitotic cell cycle 0.568711 0.245
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.568711 0.245
R-HSA-109581 Apoptosis 0.570943 0.243
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.573289 0.242
R-HSA-5578749 Transcriptional regulation by small RNAs 0.573289 0.242
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.573289 0.242
R-HSA-2467813 Separation of Sister Chromatids 0.576950 0.239
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.577819 0.238
R-HSA-5663084 Diseases of carbohydrate metabolism 0.577819 0.238
R-HSA-9006931 Signaling by Nuclear Receptors 0.582003 0.235
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.582301 0.235
R-HSA-69473 G2/M DNA damage checkpoint 0.582301 0.235
R-HSA-1236394 Signaling by ERBB4 0.582301 0.235
R-HSA-1222556 ROS and RNS production in phagocytes 0.582301 0.235
R-HSA-5689603 UCH proteinases 0.591124 0.228
R-HSA-383280 Nuclear Receptor transcription pathway 0.599761 0.222
R-HSA-5621481 C-type lectin receptors (CLRs) 0.600367 0.222
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.604011 0.219
R-HSA-76002 Platelet activation, signaling and aggregation 0.605807 0.218
R-HSA-6806834 Signaling by MET 0.608217 0.216
R-HSA-9678108 SARS-CoV-1 Infection 0.611707 0.213
R-HSA-5693607 Processing of DNA double-strand break ends 0.612378 0.213
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.616495 0.210
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.624600 0.204
R-HSA-6794362 Protein-protein interactions at synapses 0.628588 0.202
R-HSA-5687128 MAPK6/MAPK4 signaling 0.628588 0.202
R-HSA-1500620 Meiosis 0.628588 0.202
R-HSA-5673001 RAF/MAP kinase cascade 0.639319 0.194
R-HSA-69275 G2/M Transition 0.641630 0.193
R-HSA-453274 Mitotic G2-G2/M phases 0.646872 0.189
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.646872 0.189
R-HSA-202424 Downstream TCR signaling 0.651647 0.186
R-HSA-112310 Neurotransmitter release cycle 0.651647 0.186
R-HSA-73884 Base Excision Repair 0.651647 0.186
R-HSA-5617833 Cilium Assembly 0.652054 0.186
R-HSA-5684996 MAPK1/MAPK3 signaling 0.654266 0.184
R-HSA-168898 Toll-like Receptor Cascades 0.654623 0.184
R-HSA-72163 mRNA Splicing - Major Pathway 0.662238 0.179
R-HSA-1474290 Collagen formation 0.669772 0.174
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.673283 0.172
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.675814 0.170
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.677066 0.169
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.680194 0.167
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.680194 0.167
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.683594 0.165
R-HSA-422356 Regulation of insulin secretion 0.686959 0.163
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.686959 0.163
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.686959 0.163
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.686959 0.163
R-HSA-72172 mRNA Splicing 0.689017 0.162
R-HSA-192105 Synthesis of bile acids and bile salts 0.690288 0.161
R-HSA-5357801 Programmed Cell Death 0.691363 0.160
R-HSA-8953854 Metabolism of RNA 0.693103 0.159
R-HSA-69618 Mitotic Spindle Checkpoint 0.693582 0.159
R-HSA-5610787 Hedgehog 'off' state 0.693582 0.159
R-HSA-1483255 PI Metabolism 0.700066 0.155
R-HSA-397014 Muscle contraction 0.707385 0.150
R-HSA-9833110 RSV-host interactions 0.709537 0.149
R-HSA-211000 Gene Silencing by RNA 0.718710 0.143
R-HSA-1236975 Antigen processing-Cross presentation 0.721704 0.142
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.721704 0.142
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.724665 0.140
R-HSA-194068 Bile acid and bile salt metabolism 0.727596 0.138
R-HSA-6803157 Antimicrobial peptides 0.730495 0.136
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.736202 0.133
R-HSA-388396 GPCR downstream signalling 0.744312 0.128
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.744538 0.128
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.744538 0.128
R-HSA-72312 rRNA processing 0.749387 0.125
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.757853 0.120
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.757853 0.120
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.762984 0.117
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.765509 0.116
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.765509 0.116
R-HSA-2132295 MHC class II antigen presentation 0.768007 0.115
R-HSA-162909 Host Interactions of HIV factors 0.770478 0.113
R-HSA-162582 Signal Transduction 0.772816 0.112
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.777737 0.109
R-HSA-114608 Platelet degranulation 0.780105 0.108
R-HSA-69481 G2/M Checkpoints 0.780105 0.108
R-HSA-1474165 Reproduction 0.789331 0.103
R-HSA-5576891 Cardiac conduction 0.791576 0.102
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.795996 0.099
R-HSA-69620 Cell Cycle Checkpoints 0.796199 0.099
R-HSA-9018519 Estrogen-dependent gene expression 0.804559 0.094
R-HSA-163685 Integration of energy metabolism 0.804559 0.094
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.805061 0.094
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.806643 0.093
R-HSA-5358351 Signaling by Hedgehog 0.808705 0.092
R-HSA-9664407 Parasite infection 0.812764 0.090
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.812764 0.090
R-HSA-9664417 Leishmania phagocytosis 0.812764 0.090
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.814761 0.089
R-HSA-8856828 Clathrin-mediated endocytosis 0.820627 0.086
R-HSA-2871837 FCERI mediated NF-kB activation 0.822540 0.085
R-HSA-1280215 Cytokine Signaling in Immune system 0.828429 0.082
R-HSA-372790 Signaling by GPCR 0.828671 0.082
R-HSA-9658195 Leishmania infection 0.831022 0.080
R-HSA-9824443 Parasitic Infection Pathways 0.831022 0.080
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.832408 0.080
R-HSA-9609507 Protein localization 0.838876 0.076
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.842298 0.075
R-HSA-9610379 HCMV Late Events 0.845648 0.073
R-HSA-9711097 Cellular response to starvation 0.847296 0.072
R-HSA-1483257 Phospholipid metabolism 0.849517 0.071
R-HSA-9006936 Signaling by TGFB family members 0.850541 0.070
R-HSA-2408522 Selenoamino acid metabolism 0.856825 0.067
R-HSA-5619102 SLC transporter disorders 0.861365 0.065
R-HSA-9679506 SARS-CoV Infections 0.863641 0.064
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.867197 0.062
R-HSA-72306 tRNA processing 0.867197 0.062
R-HSA-418555 G alpha (s) signalling events 0.868616 0.061
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.870021 0.060
R-HSA-9664433 Leishmania parasite growth and survival 0.871410 0.060
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.871410 0.060
R-HSA-5689880 Ub-specific processing proteases 0.871410 0.060
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.872785 0.059
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.874145 0.058
R-HSA-168255 Influenza Infection 0.879442 0.056
R-HSA-8957322 Metabolism of steroids 0.882117 0.054
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.883584 0.054
R-HSA-201681 TCF dependent signaling in response to WNT 0.884517 0.053
R-HSA-1474244 Extracellular matrix organization 0.888949 0.051
R-HSA-983712 Ion channel transport 0.891735 0.050
R-HSA-9609690 HCMV Early Events 0.899590 0.046
R-HSA-389948 Co-inhibition by PD-1 0.903822 0.044
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.906878 0.042
R-HSA-1483206 Glycerophospholipid biosynthesis 0.906878 0.042
R-HSA-8951664 Neddylation 0.924117 0.034
R-HSA-199991 Membrane Trafficking 0.927709 0.033
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.931135 0.031
R-HSA-109582 Hemostasis 0.932674 0.030
R-HSA-202733 Cell surface interactions at the vascular wall 0.936144 0.029
R-HSA-425407 SLC-mediated transmembrane transport 0.938107 0.028
R-HSA-1280218 Adaptive Immune System 0.940242 0.027
R-HSA-5619115 Disorders of transmembrane transporters 0.942678 0.026
R-HSA-418594 G alpha (i) signalling events 0.943384 0.025
R-HSA-9609646 HCMV Infection 0.944506 0.025
R-HSA-597592 Post-translational protein modification 0.950405 0.022
R-HSA-9711123 Cellular response to chemical stress 0.954315 0.020
R-HSA-195721 Signaling by WNT 0.966981 0.015
R-HSA-449147 Signaling by Interleukins 0.969462 0.013
R-HSA-5653656 Vesicle-mediated transport 0.978137 0.010
R-HSA-168249 Innate Immune System 0.978166 0.010
R-HSA-196854 Metabolism of vitamins and cofactors 0.983871 0.007
R-HSA-9824446 Viral Infection Pathways 0.984798 0.007
R-HSA-168256 Immune System 0.990996 0.004
R-HSA-5668914 Diseases of metabolism 0.991972 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 0.992063 0.003
R-HSA-72766 Translation 0.992145 0.003
R-HSA-6798695 Neutrophil degranulation 0.994217 0.003
R-HSA-382551 Transport of small molecules 0.994655 0.002
R-HSA-5663205 Infectious disease 0.998299 0.001
R-HSA-392499 Metabolism of proteins 0.998967 0.000
R-HSA-1643685 Disease 0.999287 0.000
R-HSA-556833 Metabolism of lipids 0.999947 0.000
R-HSA-9709957 Sensory Perception 0.999986 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
KISKIS 0.855 0.323 1 0.734
CLK3CLK3 0.851 0.277 1 0.825
HIPK4HIPK4 0.848 0.350 1 0.821
COTCOT 0.847 0.120 2 0.822
MOSMOS 0.840 0.199 1 0.844
CDC7CDC7 0.839 0.074 1 0.814
SRPK1SRPK1 0.836 0.172 -3 0.720
GRK1GRK1 0.835 0.161 -2 0.789
NDR2NDR2 0.835 0.124 -3 0.832
PIM3PIM3 0.833 0.085 -3 0.813
PRPKPRPK 0.832 0.031 -1 0.878
PRKD1PRKD1 0.832 0.208 -3 0.816
ERK5ERK5 0.830 0.141 1 0.822
DYRK2DYRK2 0.830 0.225 1 0.773
MTORMTOR 0.829 -0.011 1 0.720
ATRATR 0.829 0.098 1 0.819
HIPK2HIPK2 0.826 0.253 1 0.693
NLKNLK 0.826 0.074 1 0.818
GCN2GCN2 0.826 -0.033 2 0.753
CDK19CDK19 0.826 0.182 1 0.668
CDKL5CDKL5 0.826 0.108 -3 0.774
SKMLCKSKMLCK 0.825 0.097 -2 0.846
CDK8CDK8 0.825 0.155 1 0.699
IKKBIKKB 0.825 -0.069 -2 0.712
CHAK2CHAK2 0.825 0.075 -1 0.804
CLK2CLK2 0.825 0.208 -3 0.698
BMPR1BBMPR1B 0.825 0.166 1 0.764
BMPR2BMPR2 0.824 0.015 -2 0.881
CDKL1CDKL1 0.824 0.066 -3 0.777
TGFBR2TGFBR2 0.822 0.044 -2 0.832
CDK1CDK1 0.822 0.158 1 0.685
DSTYKDSTYK 0.822 -0.058 2 0.848
NEK6NEK6 0.821 0.034 -2 0.869
IKKAIKKA 0.820 0.043 -2 0.708
SRPK2SRPK2 0.820 0.112 -3 0.647
PRKD2PRKD2 0.820 0.125 -3 0.737
ICKICK 0.820 0.114 -3 0.814
CAMK2GCAMK2G 0.819 -0.098 2 0.765
CDK18CDK18 0.819 0.188 1 0.660
CAMK1BCAMK1B 0.819 -0.041 -3 0.813
RSK2RSK2 0.819 0.053 -3 0.740
GRK5GRK5 0.819 -0.067 -3 0.841
PDHK4PDHK4 0.818 -0.246 1 0.776
TBK1TBK1 0.818 -0.088 1 0.622
TGFBR1TGFBR1 0.818 0.124 -2 0.835
SRPK3SRPK3 0.818 0.101 -3 0.695
RAF1RAF1 0.817 -0.149 1 0.748
P38BP38B 0.817 0.197 1 0.694
HIPK1HIPK1 0.817 0.208 1 0.778
CDK13CDK13 0.816 0.133 1 0.685
CDK5CDK5 0.816 0.153 1 0.729
IKKEIKKE 0.816 -0.096 1 0.618
GRK7GRK7 0.816 0.104 1 0.706
CDK7CDK7 0.816 0.127 1 0.711
MAPKAPK2MAPKAPK2 0.815 0.079 -3 0.709
DYRK4DYRK4 0.815 0.206 1 0.700
PIM1PIM1 0.815 0.047 -3 0.751
LATS2LATS2 0.814 0.031 -5 0.692
DAPK2DAPK2 0.814 0.008 -3 0.829
P38DP38D 0.814 0.214 1 0.635
NDR1NDR1 0.814 -0.024 -3 0.803
CAMLCKCAMLCK 0.814 -0.007 -2 0.821
ULK2ULK2 0.814 -0.164 2 0.725
PDHK1PDHK1 0.814 -0.167 1 0.758
MLK1MLK1 0.813 -0.103 2 0.765
P90RSKP90RSK 0.813 0.033 -3 0.741
CDK3CDK3 0.813 0.156 1 0.634
LATS1LATS1 0.813 0.139 -3 0.846
CAMK2DCAMK2D 0.813 -0.003 -3 0.810
NEK7NEK7 0.813 -0.124 -3 0.831
MARK4MARK4 0.813 -0.024 4 0.832
CLK4CLK4 0.812 0.114 -3 0.717
AURCAURC 0.812 0.071 -2 0.626
P38AP38A 0.812 0.166 1 0.743
ATMATM 0.812 0.037 1 0.765
ERK1ERK1 0.812 0.155 1 0.675
MAPKAPK3MAPKAPK3 0.811 0.038 -3 0.750
P38GP38G 0.811 0.152 1 0.611
NIKNIK 0.811 -0.095 -3 0.833
NUAK2NUAK2 0.811 -0.039 -3 0.791
FAM20CFAM20C 0.811 0.031 2 0.597
JNK2JNK2 0.810 0.146 1 0.660
JNK3JNK3 0.810 0.125 1 0.691
WNK1WNK1 0.810 -0.069 -2 0.866
ACVR2BACVR2B 0.810 0.090 -2 0.826
PKN3PKN3 0.810 -0.047 -3 0.784
GRK6GRK6 0.810 -0.076 1 0.777
ALK4ALK4 0.810 0.052 -2 0.858
MST4MST4 0.809 -0.058 2 0.822
MLK2MLK2 0.809 -0.008 2 0.776
CAMK2BCAMK2B 0.808 0.020 2 0.747
GRK4GRK4 0.808 -0.081 -2 0.840
CDK12CDK12 0.808 0.122 1 0.662
RIPK3RIPK3 0.808 -0.154 3 0.580
CLK1CLK1 0.808 0.109 -3 0.685
RSK3RSK3 0.808 -0.000 -3 0.727
MASTLMASTL 0.808 -0.179 -2 0.810
ACVR2AACVR2A 0.807 0.064 -2 0.819
CAMK2ACAMK2A 0.807 0.023 2 0.764
CDK17CDK17 0.807 0.143 1 0.613
TLK2TLK2 0.807 0.079 1 0.735
BCKDKBCKDK 0.807 -0.161 -1 0.760
SMG1SMG1 0.807 0.039 1 0.780
PKACGPKACG 0.806 -0.021 -2 0.706
ALK2ALK2 0.806 0.075 -2 0.841
MLK3MLK3 0.806 -0.022 2 0.689
HUNKHUNK 0.806 -0.172 2 0.758
PKCDPKCD 0.806 -0.013 2 0.727
DYRK1ADYRK1A 0.804 0.139 1 0.760
AMPKA1AMPKA1 0.804 -0.064 -3 0.816
CDK9CDK9 0.804 0.095 1 0.692
PKACBPKACB 0.804 0.060 -2 0.638
PKN2PKN2 0.803 -0.086 -3 0.789
VRK2VRK2 0.803 0.004 1 0.833
BMPR1ABMPR1A 0.803 0.095 1 0.742
P70S6KBP70S6KB 0.803 -0.039 -3 0.753
NEK9NEK9 0.803 -0.131 2 0.787
DLKDLK 0.803 -0.155 1 0.758
HIPK3HIPK3 0.803 0.162 1 0.756
TSSK1TSSK1 0.803 0.001 -3 0.836
DYRK1BDYRK1B 0.802 0.145 1 0.714
PRP4PRP4 0.802 0.115 -3 0.711
TSSK2TSSK2 0.802 -0.043 -5 0.764
DNAPKDNAPK 0.801 0.058 1 0.671
PKRPKR 0.801 -0.010 1 0.805
IRE1IRE1 0.801 -0.084 1 0.762
ANKRD3ANKRD3 0.801 -0.169 1 0.790
PKCBPKCB 0.801 -0.011 2 0.682
RSK4RSK4 0.800 0.033 -3 0.718
ULK1ULK1 0.800 -0.218 -3 0.777
CDK2CDK2 0.800 0.039 1 0.748
QSKQSK 0.800 -0.013 4 0.802
MPSK1MPSK1 0.799 0.166 1 0.745
NIM1NIM1 0.799 -0.105 3 0.635
AMPKA2AMPKA2 0.799 -0.049 -3 0.784
PKCAPKCA 0.799 -0.001 2 0.674
MAKMAK 0.798 0.210 -2 0.747
DYRK3DYRK3 0.798 0.124 1 0.790
MEK1MEK1 0.797 -0.145 2 0.794
MSK2MSK2 0.797 -0.037 -3 0.731
WNK3WNK3 0.797 -0.293 1 0.735
RIPK1RIPK1 0.797 -0.219 1 0.762
YSK4YSK4 0.797 -0.087 1 0.672
PRKD3PRKD3 0.797 0.013 -3 0.698
MSK1MSK1 0.796 0.006 -3 0.725
MLK4MLK4 0.796 -0.085 2 0.668
CK1ECK1E 0.796 0.022 -3 0.581
PLK1PLK1 0.796 -0.116 -2 0.806
PAK1PAK1 0.796 -0.051 -2 0.750
CDK14CDK14 0.796 0.111 1 0.689
PRKXPRKX 0.796 0.047 -3 0.642
ERK2ERK2 0.795 0.067 1 0.705
MNK2MNK2 0.795 -0.031 -2 0.756
CHAK1CHAK1 0.795 -0.109 2 0.742
PASKPASK 0.794 0.071 -3 0.844
PKCZPKCZ 0.794 -0.042 2 0.726
CK2A2CK2A2 0.794 0.071 1 0.726
TTBK2TTBK2 0.794 -0.217 2 0.643
IRE2IRE2 0.794 -0.091 2 0.681
PKCGPKCG 0.793 -0.068 2 0.678
CDK16CDK16 0.793 0.121 1 0.626
PKG2PKG2 0.793 -0.000 -2 0.634
PERKPERK 0.793 -0.033 -2 0.852
AURBAURB 0.792 -0.008 -2 0.624
GRK2GRK2 0.792 -0.051 -2 0.720
AURAAURA 0.792 -0.002 -2 0.605
PHKG1PHKG1 0.792 -0.080 -3 0.791
PAK3PAK3 0.792 -0.093 -2 0.739
PIM2PIM2 0.792 0.014 -3 0.705
JNK1JNK1 0.791 0.096 1 0.654
GSK3AGSK3A 0.791 0.053 4 0.468
CK1DCK1D 0.791 0.041 -3 0.534
MARK3MARK3 0.791 -0.037 4 0.765
CDK10CDK10 0.791 0.099 1 0.681
AKT2AKT2 0.791 0.014 -3 0.646
MNK1MNK1 0.790 -0.035 -2 0.761
QIKQIK 0.790 -0.152 -3 0.798
NEK2NEK2 0.790 -0.116 2 0.769
PLK3PLK3 0.789 -0.120 2 0.722
CAMK4CAMK4 0.789 -0.161 -3 0.775
SIKSIK 0.789 -0.064 -3 0.723
SGK3SGK3 0.789 -0.019 -3 0.727
MYLK4MYLK4 0.788 -0.061 -2 0.734
BUB1BUB1 0.788 0.279 -5 0.718
NUAK1NUAK1 0.788 -0.092 -3 0.738
DRAK1DRAK1 0.788 -0.095 1 0.709
MELKMELK 0.788 -0.106 -3 0.763
MARK2MARK2 0.787 -0.064 4 0.741
PKCHPKCH 0.787 -0.098 2 0.661
TLK1TLK1 0.787 -0.064 -2 0.847
GSK3BGSK3B 0.787 0.001 4 0.460
MST3MST3 0.787 -0.035 2 0.804
NEK5NEK5 0.786 -0.049 1 0.765
BRSK1BRSK1 0.786 -0.099 -3 0.747
CHK1CHK1 0.785 -0.056 -3 0.800
MOKMOK 0.785 0.153 1 0.815
TAO3TAO3 0.785 -0.034 1 0.714
PAK6PAK6 0.785 -0.030 -2 0.656
ERK7ERK7 0.785 0.053 2 0.522
PAK2PAK2 0.785 -0.109 -2 0.735
CK2A1CK2A1 0.784 0.057 1 0.709
MEKK1MEKK1 0.784 -0.140 1 0.738
CK1A2CK1A2 0.784 0.009 -3 0.531
BRSK2BRSK2 0.783 -0.130 -3 0.769
HRIHRI 0.783 -0.165 -2 0.855
DCAMKL1DCAMKL1 0.783 -0.053 -3 0.737
MEK5MEK5 0.783 -0.254 2 0.776
GAKGAK 0.783 0.013 1 0.798
ZAKZAK 0.783 -0.152 1 0.699
MEKK2MEKK2 0.783 -0.141 2 0.750
PKACAPKACA 0.782 0.016 -2 0.587
GRK3GRK3 0.782 -0.042 -2 0.687
PLK4PLK4 0.782 -0.140 2 0.559
PINK1PINK1 0.781 -0.158 1 0.801
MAPKAPK5MAPKAPK5 0.781 -0.111 -3 0.696
CK1G1CK1G1 0.780 -0.035 -3 0.555
MEKK3MEKK3 0.780 -0.230 1 0.729
WNK4WNK4 0.780 -0.138 -2 0.871
CDK6CDK6 0.780 0.086 1 0.669
MARK1MARK1 0.779 -0.114 4 0.777
LKB1LKB1 0.778 0.004 -3 0.810
BRAFBRAF 0.778 -0.190 -4 0.782
DAPK3DAPK3 0.777 -0.010 -3 0.753
CAMK1GCAMK1G 0.777 -0.097 -3 0.710
SSTKSSTK 0.777 -0.063 4 0.790
GCKGCK 0.776 -0.008 1 0.702
SMMLCKSMMLCK 0.776 -0.092 -3 0.772
CDK4CDK4 0.776 0.080 1 0.654
CAMKK2CAMKK2 0.775 -0.071 -2 0.710
EEF2KEEF2K 0.775 -0.047 3 0.712
TNIKTNIK 0.775 0.014 3 0.773
PKCTPKCT 0.775 -0.089 2 0.668
SNRKSNRK 0.775 -0.249 2 0.628
MST2MST2 0.775 -0.071 1 0.719
CAMKK1CAMKK1 0.774 -0.142 -2 0.709
IRAK4IRAK4 0.774 -0.173 1 0.757
AKT1AKT1 0.774 -0.018 -3 0.665
PDHK3_TYRPDHK3_TYR 0.773 0.280 4 0.884
PDK1PDK1 0.773 -0.106 1 0.710
PKCEPKCE 0.772 -0.041 2 0.667
TAO2TAO2 0.771 -0.139 2 0.793
NEK11NEK11 0.771 -0.201 1 0.695
VRK1VRK1 0.771 -0.062 2 0.774
P70S6KP70S6K 0.771 -0.077 -3 0.673
DAPK1DAPK1 0.770 -0.029 -3 0.739
HGKHGK 0.770 -0.056 3 0.756
MINKMINK 0.770 -0.072 1 0.692
NEK8NEK8 0.770 -0.197 2 0.767
MAP3K15MAP3K15 0.770 -0.066 1 0.676
PKCIPKCI 0.769 -0.098 2 0.691
PBKPBK 0.769 0.041 1 0.732
MEKK6MEKK6 0.769 -0.102 1 0.718
CAMK1DCAMK1D 0.769 -0.055 -3 0.641
PLK2PLK2 0.769 -0.058 -3 0.738
HPK1HPK1 0.768 -0.064 1 0.687
LRRK2LRRK2 0.768 -0.128 2 0.798
TAK1TAK1 0.767 -0.133 1 0.714
KHS1KHS1 0.767 0.000 1 0.681
DCAMKL2DCAMKL2 0.767 -0.133 -3 0.749
NEK1NEK1 0.766 -0.065 1 0.734
ROCK2ROCK2 0.766 0.013 -3 0.748
OSR1OSR1 0.766 0.032 2 0.756
NEK4NEK4 0.766 -0.151 1 0.713
MAP2K4_TYRMAP2K4_TYR 0.765 0.145 -1 0.886
PDHK4_TYRPDHK4_TYR 0.765 0.158 2 0.849
SGK1SGK1 0.765 0.001 -3 0.579
AKT3AKT3 0.765 -0.001 -3 0.596
MAP2K6_TYRMAP2K6_TYR 0.764 0.102 -1 0.884
KHS2KHS2 0.764 -0.015 1 0.694
PAK5PAK5 0.763 -0.082 -2 0.604
PHKG2PHKG2 0.763 -0.168 -3 0.728
MST1MST1 0.763 -0.112 1 0.701
PKMYT1_TYRPKMYT1_TYR 0.762 0.086 3 0.729
LOKLOK 0.761 -0.082 -2 0.726
PAK4PAK4 0.761 -0.073 -2 0.615
SBKSBK 0.761 0.024 -3 0.528
SLKSLK 0.761 -0.077 -2 0.683
TTBK1TTBK1 0.761 -0.254 2 0.560
TESK1_TYRTESK1_TYR 0.760 0.051 3 0.765
BMPR2_TYRBMPR2_TYR 0.759 0.037 -1 0.886
PDHK1_TYRPDHK1_TYR 0.758 0.015 -1 0.882
LIMK2_TYRLIMK2_TYR 0.758 0.116 -3 0.860
CHK2CHK2 0.758 -0.048 -3 0.583
MRCKBMRCKB 0.757 -0.046 -3 0.687
STK33STK33 0.757 -0.184 2 0.558
CK1ACK1A 0.757 0.004 -3 0.445
MRCKAMRCKA 0.756 -0.059 -3 0.705
TTKTTK 0.756 -0.041 -2 0.844
IRAK1IRAK1 0.756 -0.368 -1 0.719
ABL2ABL2 0.756 0.197 -1 0.804
TXKTXK 0.756 0.126 1 0.815
MEK2MEK2 0.756 -0.236 2 0.759
PKN1PKN1 0.755 -0.096 -3 0.680
YSK1YSK1 0.755 -0.130 2 0.766
EPHB4EPHB4 0.755 0.090 -1 0.833
DMPK1DMPK1 0.754 -0.004 -3 0.697
MAP2K7_TYRMAP2K7_TYR 0.754 -0.148 2 0.815
MYO3BMYO3B 0.754 -0.010 2 0.782
EPHA6EPHA6 0.753 0.041 -1 0.853
CAMK1ACAMK1A 0.753 -0.051 -3 0.601
HASPINHASPIN 0.752 -0.050 -1 0.636
ABL1ABL1 0.751 0.170 -1 0.794
BIKEBIKE 0.750 0.011 1 0.691
LCKLCK 0.748 0.067 -1 0.841
FGRFGR 0.748 0.020 1 0.799
PINK1_TYRPINK1_TYR 0.747 -0.210 1 0.778
ROCK1ROCK1 0.747 -0.034 -3 0.703
YANK3YANK3 0.747 -0.079 2 0.360
NEK3NEK3 0.747 -0.161 1 0.683
BLKBLK 0.746 0.065 -1 0.832
ALPHAK3ALPHAK3 0.746 -0.075 -1 0.806
JAK2JAK2 0.745 -0.021 1 0.723
RETRET 0.745 -0.072 1 0.735
ITKITK 0.745 0.019 -1 0.807
ASK1ASK1 0.745 -0.131 1 0.660
EPHA4EPHA4 0.745 0.015 2 0.733
RIPK2RIPK2 0.745 -0.343 1 0.647
FERFER 0.745 -0.046 1 0.817
CRIKCRIK 0.745 -0.011 -3 0.677
ROS1ROS1 0.745 -0.071 3 0.635
MST1RMST1R 0.745 -0.066 3 0.702
LIMK1_TYRLIMK1_TYR 0.745 -0.126 2 0.800
PKG1PKG1 0.744 -0.073 -2 0.555
HCKHCK 0.744 -0.008 -1 0.839
CSF1RCSF1R 0.744 -0.031 3 0.668
TYRO3TYRO3 0.744 -0.076 3 0.680
MYO3AMYO3A 0.744 -0.111 1 0.714
SRMSSRMS 0.743 -0.012 1 0.799
TYK2TYK2 0.743 -0.135 1 0.725
YES1YES1 0.743 -0.051 -1 0.840
TNK2TNK2 0.742 0.004 3 0.625
BMXBMX 0.742 0.018 -1 0.765
EPHB3EPHB3 0.740 0.000 -1 0.813
AAK1AAK1 0.740 0.073 1 0.603
EPHB2EPHB2 0.740 0.012 -1 0.808
EPHB1EPHB1 0.740 -0.039 1 0.791
TAO1TAO1 0.738 -0.134 1 0.630
TNNI3K_TYRTNNI3K_TYR 0.738 0.024 1 0.782
FYNFYN 0.738 0.027 -1 0.836
METMET 0.738 -0.008 3 0.678
JAK3JAK3 0.737 -0.111 1 0.709
MERTKMERTK 0.737 -0.009 3 0.653
KITKIT 0.736 -0.072 3 0.666
DDR1DDR1 0.736 -0.200 4 0.813
INSRRINSRR 0.735 -0.136 3 0.599
JAK1JAK1 0.735 -0.037 1 0.654
STLK3STLK3 0.732 -0.188 1 0.664
TECTEC 0.732 -0.075 -1 0.744
PTK2BPTK2B 0.731 0.040 -1 0.760
KDRKDR 0.731 -0.112 3 0.617
WEE1_TYRWEE1_TYR 0.730 -0.060 -1 0.768
FGFR2FGFR2 0.730 -0.175 3 0.647
EPHA7EPHA7 0.730 -0.054 2 0.725
TNK1TNK1 0.730 -0.073 3 0.669
EPHA3EPHA3 0.730 -0.065 2 0.699
PTK2PTK2 0.730 0.063 -1 0.818
LYNLYN 0.729 -0.060 3 0.589
PTK6PTK6 0.729 -0.129 -1 0.745
FLT3FLT3 0.728 -0.162 3 0.679
SYKSYK 0.728 0.060 -1 0.814
TEKTEK 0.728 -0.172 3 0.597
PDGFRBPDGFRB 0.728 -0.186 3 0.673
AXLAXL 0.728 -0.119 3 0.639
BTKBTK 0.726 -0.179 -1 0.768
EPHA5EPHA5 0.725 -0.033 2 0.713
NEK10_TYRNEK10_TYR 0.725 -0.122 1 0.563
DDR2DDR2 0.725 -0.053 3 0.575
SRCSRC 0.725 -0.066 -1 0.818
FGFR1FGFR1 0.724 -0.194 3 0.624
EPHA1EPHA1 0.724 -0.082 3 0.659
ALKALK 0.724 -0.153 3 0.582
NTRK3NTRK3 0.724 -0.089 -1 0.792
EPHA8EPHA8 0.723 -0.054 -1 0.803
FLT1FLT1 0.723 -0.121 -1 0.832
FRKFRK 0.723 -0.100 -1 0.825
LTKLTK 0.723 -0.141 3 0.606
NTRK1NTRK1 0.722 -0.181 -1 0.825
CK1G3CK1G3 0.721 -0.051 -3 0.395
ERBB2ERBB2 0.721 -0.177 1 0.684
FGFR3FGFR3 0.720 -0.178 3 0.616
INSRINSR 0.720 -0.168 3 0.589
MATKMATK 0.719 -0.089 -1 0.727
PDGFRAPDGFRA 0.718 -0.246 3 0.679
EGFREGFR 0.718 -0.086 1 0.603
EPHA2EPHA2 0.717 -0.033 -1 0.788
NTRK2NTRK2 0.716 -0.224 3 0.613
ZAP70ZAP70 0.714 0.072 -1 0.758
CSKCSK 0.714 -0.136 2 0.728
FGFR4FGFR4 0.713 -0.107 -1 0.782
FLT4FLT4 0.712 -0.246 3 0.599
CK1G2CK1G2 0.712 -0.036 -3 0.479
YANK2YANK2 0.710 -0.116 2 0.374
ERBB4ERBB4 0.709 -0.070 1 0.638
IGF1RIGF1R 0.707 -0.152 3 0.531
MUSKMUSK 0.701 -0.148 1 0.589
FESFES 0.699 -0.131 -1 0.737