Motif 208 (n=158)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A1W2PP11 | None | S376 | ochoa | Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) | None |
A0AV96 | RBM47 | S540 | ochoa | RNA-binding protein 47 (RNA-binding motif protein 47) | Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:27050523, PubMed:31358901). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:27050523, ECO:0000269|PubMed:30844405, ECO:0000269|PubMed:31358901, ECO:0000269|PubMed:34160127}. |
A6NE02 | BTBD17 | S42 | ochoa | BTB/POZ domain-containing protein 17 (Galectin-3-binding protein-like) | None |
E9PAV3 | NACA | S1487 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
O00192 | ARVCF | S602 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
O00267 | SUPT5H | S812 | ochoa | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
O14497 | ARID1A | S1602 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
O14523 | C2CD2L | S426 | ochoa | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}. |
O14827 | RASGRF2 | S854 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
O14828 | SCAMP3 | S72 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
O15530 | PDPK1 | S36 | ochoa | 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477, PubMed:9707564, PubMed:9768361). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9707564, PubMed:9768361). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (PubMed:10226025, PubMed:12167717, PubMed:9094314). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (PubMed:16207722). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (PubMed:14585963). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (PubMed:17371830). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity). {ECO:0000250|UniProtKB:Q9Z2A0, ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10480933, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:12167717, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16207722, ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:17371830, ECO:0000269|PubMed:18835241, ECO:0000269|PubMed:9094314, ECO:0000269|PubMed:9368760, ECO:0000269|PubMed:9445476, ECO:0000269|PubMed:9445477, ECO:0000269|PubMed:9707564, ECO:0000269|PubMed:9768361}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:9445477}. |
O15534 | PER1 | S1007 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
O43310 | CTIF | S245 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
O43639 | NCK2 | S275 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
O43639 | NCK2 | S277 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
O75146 | HIP1R | S1027 | ochoa | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}. |
O75351 | VPS4B | S108 | ochoa | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission (PubMed:18687924). Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:16193069, ECO:0000269|PubMed:18606141}. |
O75420 | GIGYF1 | S412 | ochoa | GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1) | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:12771153}. |
O75533 | SF3B1 | S377 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
O75914 | PAK3 | S220 | ochoa | Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:21177870}. |
O76061 | STC2 | S250 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
O94823 | ATP10B | S1371 | ochoa | Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B) | Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269|PubMed:32172343}. |
O95180 | CACNA1H | S44 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
O95278 | EPM2A | S25 | psp | Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) | Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:25538239, PubMed:25544560, PubMed:26231210). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:14722920, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin (PubMed:23922729). Also promotes proteasome-independent protein degradation through the macroautophagy pathway (PubMed:20453062). {ECO:0000250|UniProtKB:Q9WUA5, ECO:0000269|PubMed:11001928, ECO:0000269|PubMed:11220751, ECO:0000269|PubMed:11739371, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:14722920, ECO:0000269|PubMed:16901901, ECO:0000269|PubMed:16971387, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:20453062, ECO:0000269|PubMed:22036712, ECO:0000269|PubMed:23624058, ECO:0000269|PubMed:23922729, ECO:0000269|PubMed:25538239, ECO:0000269|PubMed:25544560, ECO:0000269|PubMed:26231210}.; FUNCTION: [Isoform 2]: Does not bind to glycogen (PubMed:18617530). Lacks phosphatase activity and might function as a dominant-negative regulator for the phosphatase activity of isoform 1 and isoform 7 (PubMed:18617530, PubMed:22036712). {ECO:0000269|PubMed:18617530, ECO:0000269|PubMed:22036712}.; FUNCTION: [Isoform 7]: Has phosphatase activity (in vitro). {ECO:0000269|PubMed:22036712}. |
O95503 | CBX6 | S246 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
O95622 | ADCY5 | S155 | ochoa | Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:24700542, PubMed:26206488). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569, ECO:0000269|PubMed:26206488}. |
P00519 | ABL1 | S828 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
P03372 | ESR1 | S46 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
P04233 | CD74 | S45 | psp | HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)] | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}. |
P06127 | CD5 | S454 | ochoa | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
P07199 | CENPB | S168 | ochoa | Major centromere autoantigen B (Centromere protein B) (CENP-B) | Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). {ECO:0000269|PubMed:11726497, ECO:0000305}. |
P08237 | PFKM | S398 | ochoa | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
P08833 | IGFBP1 | S83 | psp | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:11397844, PubMed:15972819). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif (PubMed:7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:P21743, ECO:0000269|PubMed:11397844, ECO:0000269|PubMed:15972819, ECO:0000269|PubMed:3419931, ECO:0000269|PubMed:7504269}. |
P0C7M8 | CLEC2L | S55 | ochoa | C-type lectin domain family 2 member L | None |
P16402 | H1-3 | S42 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
P17600 | SYN1 | S71 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
P18031 | PTPN1 | S365 | ochoa | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) | Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}. |
P21333 | FLNA | S2048 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P21333 | FLNA | S2279 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P28290 | ITPRID2 | S1134 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
P28715 | ERCC5 | S356 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
P42166 | TMPO | S66 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
P42684 | ABL2 | S866 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
P46013 | MKI67 | S2925 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46087 | NOP2 | S666 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
P46089 | GPR3 | S237 | psp | G-protein coupled receptor 3 (ACCA orphan receptor) | Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700}. |
P46379 | BAG6 | S985 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
P50502 | ST13 | S181 | ochoa | Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein) | One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}. |
P51531 | SMARCA2 | S591 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SAMRCA2) (EC 3.6.4.-) (BRG1-associated factor 190B) (BAF190B) (Probable global transcription activator SNF2L2) (Protein brahma homolog) (hBRM) (SNF2-alpha) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6DIC0, ECO:0000269|PubMed:15075294, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P51532 | SMARCA4 | S613 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P55011 | SLC12A2 | S77 | ochoa|psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
P55011 | SLC12A2 | S79 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
P61964 | WDR5 | S22 | ochoa | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:P61965, ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:18840606, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
P78559 | MAP1A | Y773 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
Q00536 | CDK16 | S65 | ochoa|psp | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
Q12770 | SCAP | S943 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
Q13428 | TCOF1 | S475 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q14315 | FLNC | S1156 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
Q14653 | IRF3 | S188 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
Q14676 | MDC1 | S376 | ochoa|psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q14761 | PTPRCAP | S178 | ochoa | Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein) | None |
Q14766 | LTBP1 | S494 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
Q15149 | PLEC | S647 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q15274 | QPRT | S42 | ochoa | Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase) | Involved in the catabolism of quinolinic acid (QA). {ECO:0000269|PubMed:17868694, ECO:0000269|PubMed:24038671, ECO:0000269|PubMed:9473669}. |
Q16566 | CAMK4 | S189 | ochoa | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. |
Q3T8J9 | GON4L | S1571 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
Q3YEC7 | RABL6 | S365 | ochoa | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}. |
Q5VST9 | OBSCN | S6868 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
Q5VT06 | CEP350 | S1274 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
Q5VV41 | ARHGEF16 | S107 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
Q66K64 | DCAF15 | S314 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
Q66K74 | MAP1S | S610 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
Q674R7 | ATG9B | S867 | ochoa | Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}. |
Q69YH5 | CDCA2 | S960 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
Q6IAA8 | LAMTOR1 | S42 | ochoa | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). {ECO:0000250|UniProtKB:Q9CQ22, ECO:0000269|PubMed:19654316, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:20544018, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29123114, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:29285400, ECO:0000269|PubMed:30181260, ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:36476874}. |
Q6NUJ5 | PWWP2B | S291 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
Q6P1R3 | MSANTD2 | S39 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
Q6P4R8 | NFRKB | S1033 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
Q6UB99 | ANKRD11 | Y1851 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6UUV7 | CRTC3 | S169 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
Q6ZMQ8 | AATK | S520 | ochoa | Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) | May be involved in neuronal differentiation. {ECO:0000269|PubMed:10837911}. |
Q7KZI7 | MARK2 | S498 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q7Z5K2 | WAPL | S305 | psp | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}. |
Q86YV0 | RASAL3 | S58 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
Q86YV5 | PRAG1 | S879 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
Q8IVL1 | NAV2 | S2365 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
Q8IX01 | SUGP2 | S772 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
Q8IZP2 | ST13P4 | S177 | ochoa | Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4) | None |
Q8N3E9 | PLCD3 | S559 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}. |
Q8NBR6 | MINDY2 | S26 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
Q8ND56 | LSM14A | S219 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
Q8NFH5 | NUP35 | S25 | ochoa | Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}. |
Q8NI35 | PATJ | S351 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
Q8TAQ2 | SMARCC2 | S745 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q8TBA6 | GOLGA5 | S88 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
Q8TBC5 | ZSCAN18 | S345 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
Q8TD08 | MAPK15 | S379 | psp | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
Q8TEK3 | DOT1L | S1243 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8TER5 | ARHGEF40 | S1491 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
Q8TF44 | C2CD4C | S74 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
Q8TF71 | SLC16A10 | S36 | ochoa | Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000269|PubMed:11827462, ECO:0000269|PubMed:18337592, ECO:0000269|PubMed:28754537}. |
Q8WZ73 | RFFL | S35 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
Q96A59 | MARVELD3 | S113 | ochoa | MARVEL domain-containing protein 3 | As a component of tight junctions, plays a role in paracellular ion conductivity. {ECO:0000269|PubMed:20028514}. |
Q96L91 | EP400 | S2086 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Q9BQI7 | PSD2 | S191 | ochoa | PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2) | None |
Q9BT25 | HAUS8 | S357 | ochoa | HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:18362163, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
Q9BTC0 | DIDO1 | S500 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BTK6 | PAGR1 | S26 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
Q9BTU6 | PI4K2A | S22 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
Q9BWH6 | RPAP1 | S200 | ochoa | RNA polymerase II-associated protein 1 | Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
Q9BYB0 | SHANK3 | S366 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BYB0 | SHANK3 | S1539 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BZL4 | PPP1R12C | S602 | ochoa | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
Q9BZS1 | FOXP3 | S274 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
Q9C0J8 | WDR33 | S266 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
Q9H1A4 | ANAPC1 | S529 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
Q9H1B7 | IRF2BPL | S519 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
Q9H211 | CDT1 | S411 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
Q9H4L5 | OSBPL3 | S265 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
Q9H4Z2 | ZNF335 | S991 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
Q9H5N1 | RABEP2 | S200 | ochoa | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}. |
Q9H814 | PHAX | S39 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
Q9H9H5 | MAP6D1 | S167 | ochoa | MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21) | May have microtubule-stabilizing activity. {ECO:0000250}. |
Q9HC52 | CBX8 | S256 | ochoa | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
Q9NR30 | DDX21 | S592 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
Q9NR33 | POLE4 | S32 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
Q9NSY1 | BMP2K | S392 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
Q9NSY1 | BMP2K | S1135 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
Q9NZ56 | FMN2 | S317 | ochoa | Formin-2 | Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}. |
Q9NZM4 | BICRA | S1413 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269|PubMed:21555454, ECO:0000269|PubMed:29374058}. |
Q9P206 | NHSL3 | S529 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9P266 | JCAD | S696 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
Q9P273 | TENM3 | S111 | ochoa | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. {ECO:0000250|UniProtKB:Q9WTS6}. |
Q9UJ90 | KCNE5 | S95 | ochoa | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (AMME syndrome candidate gene 2 protein) (Potassium channel subunit beta MiRP4) (Potassium voltage-gated channel subfamily E member 1-like protein) | Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}. |
Q9UJD0 | RIMS3 | S22 | ochoa | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3) | Regulates synaptic membrane exocytosis. {ECO:0000250}. |
Q9UNZ2 | NSFL1C | S140 | ochoa|psp | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
Q9UPA5 | BSN | S2899 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
Q9UPN4 | CEP131 | S417 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
Q9UPU5 | USP24 | S2551 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
Q9UQB3 | CTNND2 | S461 | ochoa | Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) | Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. {ECO:0000250|UniProtKB:O35927, ECO:0000269|PubMed:25807484, ECO:0000269|PubMed:9971746}. |
Q9Y261 | FOXA2 | S307 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
Q9Y3Q8 | TSC22D4 | S279 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
Q9Y4H2 | IRS2 | S406 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
R4GMW8 | BIVM-ERCC5 | S810 | ochoa | DNA excision repair protein ERCC-5 | None |
P34932 | HSPA4 | S31 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
P34932 | HSPA4 | S40 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
Q13155 | AIMP2 | S51 | Sugiyama | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
Q8NFI4 | ST13P5 | S181 | Sugiyama | Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5) | None |
P05187 | ALPP | S192 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
P10696 | ALPG | S189 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
P42167 | TMPO | S66 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
P09923 | ALPI | S189 | Sugiyama | Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000250|UniProtKB:P15693}. |
P14866 | HNRNPL | S471 | Sugiyama | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284, ECO:0000269|PubMed:33174841, ECO:0000269|PubMed:36537238}. |
Q96EP5 | DAZAP1 | S195 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
O43175 | PHGDH | S280 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
P51452 | DUSP3 | S43 | Sugiyama | Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) | Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:10224087, PubMed:11863439). {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}. |
Q8TD08 | MAPK15 | S447 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
P14598 | NCF1 | S288 | SIGNOR|EPSD|PSP | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.000005 | 5.341 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.000023 | 4.633 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.000023 | 4.633 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.000037 | 4.431 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000074 | 4.128 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.000162 | 3.789 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.000259 | 3.587 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.000994 | 3.003 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.000994 | 3.003 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.001160 | 2.936 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.002609 | 2.584 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.002437 | 2.613 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.004264 | 2.370 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.004264 | 2.370 |
R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.005228 | 2.282 |
R-HSA-193648 | NRAGE signals death through JNK | 0.005072 | 2.295 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.005012 | 2.300 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.006258 | 2.204 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.005647 | 2.248 |
R-HSA-74160 | Gene expression (Transcription) | 0.006178 | 2.209 |
R-HSA-4839726 | Chromatin organization | 0.008484 | 2.071 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.008654 | 2.063 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.008014 | 2.096 |
R-HSA-212436 | Generic Transcription Pathway | 0.008726 | 2.059 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.009564 | 2.019 |
R-HSA-428540 | Activation of RAC1 | 0.011363 | 1.945 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.011576 | 1.936 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.011581 | 1.936 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.011339 | 1.945 |
R-HSA-9796292 | Formation of axial mesoderm | 0.014395 | 1.842 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.014395 | 1.842 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.014395 | 1.842 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.012705 | 1.896 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.013839 | 1.859 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.013900 | 1.857 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.013839 | 1.859 |
R-HSA-194138 | Signaling by VEGF | 0.017453 | 1.758 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.017735 | 1.751 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.051719 | 1.286 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.051719 | 1.286 |
R-HSA-74713 | IRS activation | 0.071653 | 1.145 |
R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.071653 | 1.145 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 0.091172 | 1.040 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.100777 | 0.997 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.100777 | 0.997 |
R-HSA-112412 | SOS-mediated signalling | 0.100777 | 0.997 |
R-HSA-446107 | Type I hemidesmosome assembly | 0.110282 | 0.957 |
R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.110282 | 0.957 |
R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 0.119686 | 0.922 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.128992 | 0.889 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.128992 | 0.889 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.147312 | 0.832 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.156327 | 0.806 |
R-HSA-170660 | Adenylate cyclase activating pathway | 0.165248 | 0.782 |
R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.062310 | 1.205 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.182809 | 0.738 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.182809 | 0.738 |
R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.182809 | 0.738 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.191452 | 0.718 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.191452 | 0.718 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.071080 | 1.148 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.200003 | 0.699 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.086511 | 1.063 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.216837 | 0.664 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.089709 | 1.047 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.225122 | 0.648 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.225122 | 0.648 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.099505 | 1.002 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.241430 | 0.617 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.249456 | 0.603 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.249456 | 0.603 |
R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.066349 | 1.178 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.137640 | 0.861 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.295869 | 0.529 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.295869 | 0.529 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.035942 | 1.444 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.303322 | 0.518 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.303322 | 0.518 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.310697 | 0.508 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.174568 | 0.758 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.174568 | 0.758 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.110822 | 0.955 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.185941 | 0.731 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.212844 | 0.672 |
R-HSA-380287 | Centrosome maturation | 0.220602 | 0.656 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.275329 | 0.560 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.247911 | 0.606 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.283160 | 0.548 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.074088 | 1.130 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.276229 | 0.559 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.187254 | 0.728 |
R-HSA-198203 | PI3K/AKT activation | 0.128992 | 0.889 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.187254 | 0.728 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.187254 | 0.728 |
R-HSA-8939211 | ESR-mediated signaling | 0.291849 | 0.535 |
R-HSA-5576890 | Phase 3 - rapid repolarisation | 0.100777 | 0.997 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.021369 | 1.670 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.156327 | 0.806 |
R-HSA-6782135 | Dual incision in TC-NER | 0.155891 | 0.807 |
R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.071653 | 1.145 |
R-HSA-165158 | Activation of AKT2 | 0.071653 | 1.145 |
R-HSA-8849472 | PTK6 Down-Regulation | 0.071653 | 1.145 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.208465 | 0.681 |
R-HSA-112399 | IRS-mediated signalling | 0.152203 | 0.818 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.303322 | 0.518 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.167052 | 0.777 |
R-HSA-3928664 | Ephrin signaling | 0.025284 | 1.597 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.200003 | 0.699 |
R-HSA-72086 | mRNA Capping | 0.310697 | 0.508 |
R-HSA-9734767 | Developmental Cell Lineages | 0.032434 | 1.489 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.159595 | 0.797 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.110282 | 0.957 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.303322 | 0.518 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.032313 | 1.491 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.126868 | 0.897 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.126868 | 0.897 |
R-HSA-68962 | Activation of the pre-replicative complex | 0.056687 | 1.247 |
R-HSA-8985801 | Regulation of cortical dendrite branching | 0.041592 | 1.381 |
R-HSA-68952 | DNA replication initiation | 0.128992 | 0.889 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.147312 | 0.832 |
R-HSA-202670 | ERKs are inactivated | 0.147312 | 0.832 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.182809 | 0.738 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.071080 | 1.148 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.200003 | 0.699 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.216837 | 0.664 |
R-HSA-164378 | PKA activation in glucagon signalling | 0.216837 | 0.664 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.025611 | 1.592 |
R-HSA-109704 | PI3K Cascade | 0.126936 | 0.896 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.273031 | 0.564 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.273031 | 0.564 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.189755 | 0.722 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.208975 | 0.680 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.178347 | 0.749 |
R-HSA-2428924 | IGF1R signaling cascade | 0.178347 | 0.749 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.092941 | 1.032 |
R-HSA-9823730 | Formation of definitive endoderm | 0.029466 | 1.531 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.128992 | 0.889 |
R-HSA-74749 | Signal attenuation | 0.128992 | 0.889 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.065190 | 1.186 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.233319 | 0.632 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.205113 | 0.688 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.182138 | 0.740 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.220602 | 0.656 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.129226 | 0.889 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.182809 | 0.738 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.257398 | 0.589 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.075585 | 1.122 |
R-HSA-112040 | G-protein mediated events | 0.189755 | 0.722 |
R-HSA-74752 | Signaling by Insulin receptor | 0.095634 | 1.019 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.242129 | 0.616 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.216837 | 0.664 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.119892 | 0.921 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.021369 | 1.670 |
R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.128992 | 0.889 |
R-HSA-5576893 | Phase 2 - plateau phase | 0.200003 | 0.699 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.200003 | 0.699 |
R-HSA-420029 | Tight junction interactions | 0.280724 | 0.552 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.295869 | 0.529 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.159595 | 0.797 |
R-HSA-191859 | snRNP Assembly | 0.159595 | 0.797 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.255741 | 0.592 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.288337 | 0.540 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.138809 | 0.858 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.152203 | 0.818 |
R-HSA-111933 | Calmodulin induced events | 0.077137 | 1.113 |
R-HSA-6811438 | Intra-Golgi traffic | 0.096207 | 1.017 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.212844 | 0.672 |
R-HSA-111997 | CaM pathway | 0.077137 | 1.113 |
R-HSA-525793 | Myogenesis | 0.288337 | 0.540 |
R-HSA-68882 | Mitotic Anaphase | 0.242944 | 0.614 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.273366 | 0.563 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.092941 | 1.032 |
R-HSA-3322077 | Glycogen synthesis | 0.233319 | 0.632 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.267494 | 0.573 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.245231 | 0.610 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.147312 | 0.832 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.200003 | 0.699 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.036543 | 1.437 |
R-HSA-1834941 | STING mediated induction of host immune responses | 0.225122 | 0.648 |
R-HSA-68886 | M Phase | 0.258406 | 0.588 |
R-HSA-111996 | Ca-dependent events | 0.099505 | 1.002 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.061739 | 1.209 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.100777 | 0.997 |
R-HSA-444257 | RSK activation | 0.110282 | 0.957 |
R-HSA-877312 | Regulation of IFNG signaling | 0.156327 | 0.806 |
R-HSA-163615 | PKA activation | 0.216837 | 0.664 |
R-HSA-1489509 | DAG and IP3 signaling | 0.109583 | 0.960 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.249456 | 0.603 |
R-HSA-166208 | mTORC1-mediated signalling | 0.257398 | 0.589 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.265256 | 0.576 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.310697 | 0.508 |
R-HSA-162587 | HIV Life Cycle | 0.284837 | 0.545 |
R-HSA-438064 | Post NMDA receptor activation events | 0.083360 | 1.079 |
R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.200003 | 0.699 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.310697 | 0.508 |
R-HSA-112043 | PLC beta mediated events | 0.167052 | 0.777 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.298799 | 0.525 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.096973 | 1.013 |
R-HSA-389356 | Co-stimulation by CD28 | 0.119918 | 0.921 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.071653 | 1.145 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.156327 | 0.806 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.156327 | 0.806 |
R-HSA-9005895 | Pervasive developmental disorders | 0.156327 | 0.806 |
R-HSA-3229121 | Glycogen storage diseases | 0.208465 | 0.681 |
R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.257398 | 0.589 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.265256 | 0.576 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.265256 | 0.576 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.288337 | 0.540 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.295869 | 0.529 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.220602 | 0.656 |
R-HSA-9909396 | Circadian clock | 0.074064 | 1.130 |
R-HSA-69306 | DNA Replication | 0.273366 | 0.563 |
R-HSA-3371556 | Cellular response to heat stress | 0.174088 | 0.759 |
R-HSA-1640170 | Cell Cycle | 0.089245 | 1.049 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.021369 | 1.670 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.128992 | 0.889 |
R-HSA-389359 | CD28 dependent Vav1 pathway | 0.165248 | 0.782 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.216837 | 0.664 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.288337 | 0.540 |
R-HSA-77387 | Insulin receptor recycling | 0.303322 | 0.518 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.170803 | 0.768 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.019533 | 1.709 |
R-HSA-373753 | Nephrin family interactions | 0.233319 | 0.632 |
R-HSA-376176 | Signaling by ROBO receptors | 0.211503 | 0.675 |
R-HSA-69239 | Synthesis of DNA | 0.133988 | 0.873 |
R-HSA-69242 | S Phase | 0.101795 | 0.992 |
R-HSA-982772 | Growth hormone receptor signaling | 0.038579 | 1.414 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.051254 | 1.290 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.182809 | 0.738 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.241430 | 0.617 |
R-HSA-198753 | ERK/MAPK targets | 0.241430 | 0.617 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.249456 | 0.603 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.059309 | 1.227 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.193581 | 0.713 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.153618 | 0.814 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.119892 | 0.921 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.035067 | 1.455 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.233847 | 0.631 |
R-HSA-2559583 | Cellular Senescence | 0.062266 | 1.206 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.074088 | 1.130 |
R-HSA-877300 | Interferon gamma signaling | 0.290589 | 0.537 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.240090 | 0.620 |
R-HSA-977347 | Serine metabolism | 0.249456 | 0.603 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.240090 | 0.620 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.294893 | 0.530 |
R-HSA-909733 | Interferon alpha/beta signaling | 0.158661 | 0.800 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.270686 | 0.568 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.033216 | 1.479 |
R-HSA-69206 | G1/S Transition | 0.187254 | 0.728 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.300929 | 0.522 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.020047 | 1.698 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.119686 | 0.922 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.265256 | 0.576 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.051150 | 1.291 |
R-HSA-2586552 | Signaling by Leptin | 0.128992 | 0.889 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.119686 | 0.922 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.069870 | 1.156 |
R-HSA-381042 | PERK regulates gene expression | 0.074088 | 1.130 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.225122 | 0.648 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.273031 | 0.564 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.288337 | 0.540 |
R-HSA-1500931 | Cell-Cell communication | 0.027973 | 1.553 |
R-HSA-446728 | Cell junction organization | 0.040941 | 1.388 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.151115 | 0.821 |
R-HSA-354192 | Integrin signaling | 0.065190 | 1.186 |
R-HSA-9706369 | Negative regulation of FLT3 | 0.191452 | 0.718 |
R-HSA-6807004 | Negative regulation of MET activity | 0.233319 | 0.632 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.280724 | 0.552 |
R-HSA-210745 | Regulation of gene expression in beta cells | 0.310697 | 0.508 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.098504 | 1.007 |
R-HSA-1266695 | Interleukin-7 signaling | 0.043487 | 1.362 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.046023 | 1.337 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.280724 | 0.552 |
R-HSA-9659379 | Sensory processing of sound | 0.236184 | 0.627 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.109583 | 0.960 |
R-HSA-5693538 | Homology Directed Repair | 0.166321 | 0.779 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.233541 | 0.632 |
R-HSA-69205 | G1/S-Specific Transcription | 0.077137 | 1.113 |
R-HSA-6807070 | PTEN Regulation | 0.230922 | 0.637 |
R-HSA-8983711 | OAS antiviral response | 0.156327 | 0.806 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.077137 | 1.113 |
R-HSA-8953897 | Cellular responses to stimuli | 0.041820 | 1.379 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.091464 | 1.039 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.310697 | 0.508 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.243999 | 0.613 |
R-HSA-2262752 | Cellular responses to stress | 0.215578 | 0.666 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.096207 | 1.017 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.086511 | 1.063 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.276229 | 0.559 |
R-HSA-75153 | Apoptotic execution phase | 0.113001 | 0.947 |
R-HSA-8853659 | RET signaling | 0.077137 | 1.113 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.303322 | 0.518 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.105137 | 0.978 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.103942 | 0.983 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.259739 | 0.585 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.030550 | 1.515 |
R-HSA-73887 | Death Receptor Signaling | 0.111968 | 0.951 |
R-HSA-9675108 | Nervous system development | 0.311477 | 0.507 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.317994 | 0.498 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.317994 | 0.498 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.317994 | 0.498 |
R-HSA-421270 | Cell-cell junction organization | 0.325172 | 0.488 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.325214 | 0.488 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.325214 | 0.488 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.325214 | 0.488 |
R-HSA-2129379 | Molecules associated with elastic fibres | 0.325214 | 0.488 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.325214 | 0.488 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.325214 | 0.488 |
R-HSA-186763 | Downstream signal transduction | 0.325214 | 0.488 |
R-HSA-3214847 | HATs acetylate histones | 0.326024 | 0.487 |
R-HSA-9614085 | FOXO-mediated transcription | 0.326024 | 0.487 |
R-HSA-70171 | Glycolysis | 0.329893 | 0.482 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.332359 | 0.478 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.332359 | 0.478 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.333905 | 0.476 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.333905 | 0.476 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.337613 | 0.472 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.339428 | 0.469 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.339428 | 0.469 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.339428 | 0.469 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.339428 | 0.469 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.339428 | 0.469 |
R-HSA-9733709 | Cardiogenesis | 0.339428 | 0.469 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.339428 | 0.469 |
R-HSA-1266738 | Developmental Biology | 0.344937 | 0.462 |
R-HSA-111885 | Opioid Signalling | 0.345306 | 0.462 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.346422 | 0.460 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.346422 | 0.460 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.346422 | 0.460 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.346422 | 0.460 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.346422 | 0.460 |
R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.349142 | 0.457 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.352971 | 0.452 |
R-HSA-180746 | Nuclear import of Rev protein | 0.353343 | 0.452 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.356792 | 0.448 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.360192 | 0.443 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.364409 | 0.438 |
R-HSA-114604 | GPVI-mediated activation cascade | 0.366968 | 0.435 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.366968 | 0.435 |
R-HSA-202403 | TCR signaling | 0.371992 | 0.429 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.371992 | 0.429 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.371992 | 0.429 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.373672 | 0.428 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.373672 | 0.428 |
R-HSA-419037 | NCAM1 interactions | 0.373672 | 0.428 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.373672 | 0.428 |
R-HSA-73894 | DNA Repair | 0.378127 | 0.422 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.379539 | 0.421 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.380306 | 0.420 |
R-HSA-1566948 | Elastic fibre formation | 0.380306 | 0.420 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.380306 | 0.420 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.386871 | 0.412 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.386871 | 0.412 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.386871 | 0.412 |
R-HSA-68877 | Mitotic Prometaphase | 0.391438 | 0.407 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.392299 | 0.406 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.393366 | 0.405 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.393366 | 0.405 |
R-HSA-167169 | HIV Transcription Elongation | 0.393366 | 0.405 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.393366 | 0.405 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.393366 | 0.405 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.393366 | 0.405 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.393366 | 0.405 |
R-HSA-8982491 | Glycogen metabolism | 0.393366 | 0.405 |
R-HSA-202433 | Generation of second messenger molecules | 0.393366 | 0.405 |
R-HSA-422475 | Axon guidance | 0.395386 | 0.403 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.399793 | 0.398 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.399793 | 0.398 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.399793 | 0.398 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.399793 | 0.398 |
R-HSA-9607240 | FLT3 Signaling | 0.399793 | 0.398 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.399982 | 0.398 |
R-HSA-70326 | Glucose metabolism | 0.405646 | 0.392 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.405646 | 0.392 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.406152 | 0.391 |
R-HSA-991365 | Activation of GABAB receptors | 0.412444 | 0.385 |
R-HSA-977444 | GABA B receptor activation | 0.412444 | 0.385 |
R-HSA-165159 | MTOR signalling | 0.412444 | 0.385 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.412444 | 0.385 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.412444 | 0.385 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.413010 | 0.384 |
R-HSA-68875 | Mitotic Prophase | 0.416675 | 0.380 |
R-HSA-112316 | Neuronal System | 0.418331 | 0.378 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.418669 | 0.378 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.424829 | 0.372 |
R-HSA-69236 | G1 Phase | 0.424829 | 0.372 |
R-HSA-913531 | Interferon Signaling | 0.428362 | 0.368 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.430925 | 0.366 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.430925 | 0.366 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.430925 | 0.366 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.436956 | 0.360 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.436956 | 0.360 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.436956 | 0.360 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.442923 | 0.354 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.448828 | 0.348 |
R-HSA-9634597 | GPER1 signaling | 0.448828 | 0.348 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.449129 | 0.348 |
R-HSA-73893 | DNA Damage Bypass | 0.454670 | 0.342 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.460451 | 0.337 |
R-HSA-418990 | Adherens junctions interactions | 0.464185 | 0.333 |
R-HSA-72187 | mRNA 3'-end processing | 0.471831 | 0.326 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.471831 | 0.326 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.471831 | 0.326 |
R-HSA-68949 | Orc1 removal from chromatin | 0.471831 | 0.326 |
R-HSA-6794361 | Neurexins and neuroligins | 0.471831 | 0.326 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.471831 | 0.326 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.477431 | 0.321 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.477431 | 0.321 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.477431 | 0.321 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 0.477431 | 0.321 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.477431 | 0.321 |
R-HSA-1221632 | Meiotic synapsis | 0.477431 | 0.321 |
R-HSA-445355 | Smooth Muscle Contraction | 0.477431 | 0.321 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.482972 | 0.316 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.488396 | 0.311 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.488454 | 0.311 |
R-HSA-418597 | G alpha (z) signalling events | 0.488454 | 0.311 |
R-HSA-162906 | HIV Infection | 0.488513 | 0.311 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.493879 | 0.306 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.493879 | 0.306 |
R-HSA-8935690 | Digestion | 0.493879 | 0.306 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.493879 | 0.306 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.494162 | 0.306 |
R-HSA-1483166 | Synthesis of PA | 0.499246 | 0.302 |
R-HSA-1632852 | Macroautophagy | 0.500883 | 0.300 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.504557 | 0.297 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.507548 | 0.295 |
R-HSA-186712 | Regulation of beta-cell development | 0.509812 | 0.293 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.509812 | 0.293 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.509812 | 0.293 |
R-HSA-977443 | GABA receptor activation | 0.515012 | 0.288 |
R-HSA-379724 | tRNA Aminoacylation | 0.515012 | 0.288 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.515012 | 0.288 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.520156 | 0.284 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.520156 | 0.284 |
R-HSA-445717 | Aquaporin-mediated transport | 0.520156 | 0.284 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.520156 | 0.284 |
R-HSA-450294 | MAP kinase activation | 0.520156 | 0.284 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.525247 | 0.280 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.525247 | 0.280 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.525247 | 0.280 |
R-HSA-9707616 | Heme signaling | 0.525247 | 0.280 |
R-HSA-186797 | Signaling by PDGF | 0.525247 | 0.280 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.525247 | 0.280 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.527192 | 0.278 |
R-HSA-166520 | Signaling by NTRKs | 0.527192 | 0.278 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.530283 | 0.275 |
R-HSA-373755 | Semaphorin interactions | 0.530283 | 0.275 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.530283 | 0.275 |
R-HSA-8848021 | Signaling by PTK6 | 0.530283 | 0.275 |
R-HSA-8963743 | Digestion and absorption | 0.530283 | 0.275 |
R-HSA-9758941 | Gastrulation | 0.530414 | 0.275 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.535267 | 0.271 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.545077 | 0.264 |
R-HSA-5683057 | MAPK family signaling cascades | 0.548270 | 0.261 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.549905 | 0.260 |
R-HSA-196807 | Nicotinate metabolism | 0.549905 | 0.260 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.549905 | 0.260 |
R-HSA-9612973 | Autophagy | 0.552555 | 0.258 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.552563 | 0.258 |
R-HSA-167172 | Transcription of the HIV genome | 0.554681 | 0.256 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.554681 | 0.256 |
R-HSA-5688426 | Deubiquitination | 0.560533 | 0.251 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.562992 | 0.249 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.564084 | 0.249 |
R-HSA-448424 | Interleukin-17 signaling | 0.564084 | 0.249 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.564874 | 0.248 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.568711 | 0.245 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.568711 | 0.245 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.568711 | 0.245 |
R-HSA-109581 | Apoptosis | 0.570943 | 0.243 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.573289 | 0.242 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.573289 | 0.242 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.573289 | 0.242 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.576950 | 0.239 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.577819 | 0.238 |
R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.577819 | 0.238 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.582003 | 0.235 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.582301 | 0.235 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.582301 | 0.235 |
R-HSA-1236394 | Signaling by ERBB4 | 0.582301 | 0.235 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 0.582301 | 0.235 |
R-HSA-5689603 | UCH proteinases | 0.591124 | 0.228 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.599761 | 0.222 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.600367 | 0.222 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.604011 | 0.219 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.605807 | 0.218 |
R-HSA-6806834 | Signaling by MET | 0.608217 | 0.216 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.611707 | 0.213 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.612378 | 0.213 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.616495 | 0.210 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.624600 | 0.204 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.628588 | 0.202 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.628588 | 0.202 |
R-HSA-1500620 | Meiosis | 0.628588 | 0.202 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.639319 | 0.194 |
R-HSA-69275 | G2/M Transition | 0.641630 | 0.193 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.646872 | 0.189 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.646872 | 0.189 |
R-HSA-202424 | Downstream TCR signaling | 0.651647 | 0.186 |
R-HSA-112310 | Neurotransmitter release cycle | 0.651647 | 0.186 |
R-HSA-73884 | Base Excision Repair | 0.651647 | 0.186 |
R-HSA-5617833 | Cilium Assembly | 0.652054 | 0.186 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.654266 | 0.184 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.654623 | 0.184 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.662238 | 0.179 |
R-HSA-1474290 | Collagen formation | 0.669772 | 0.174 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.673283 | 0.172 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.675814 | 0.170 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.677066 | 0.169 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.680194 | 0.167 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.680194 | 0.167 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.683594 | 0.165 |
R-HSA-422356 | Regulation of insulin secretion | 0.686959 | 0.163 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.686959 | 0.163 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.686959 | 0.163 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.686959 | 0.163 |
R-HSA-72172 | mRNA Splicing | 0.689017 | 0.162 |
R-HSA-192105 | Synthesis of bile acids and bile salts | 0.690288 | 0.161 |
R-HSA-5357801 | Programmed Cell Death | 0.691363 | 0.160 |
R-HSA-8953854 | Metabolism of RNA | 0.693103 | 0.159 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.693582 | 0.159 |
R-HSA-5610787 | Hedgehog 'off' state | 0.693582 | 0.159 |
R-HSA-1483255 | PI Metabolism | 0.700066 | 0.155 |
R-HSA-397014 | Muscle contraction | 0.707385 | 0.150 |
R-HSA-9833110 | RSV-host interactions | 0.709537 | 0.149 |
R-HSA-211000 | Gene Silencing by RNA | 0.718710 | 0.143 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.721704 | 0.142 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.721704 | 0.142 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.724665 | 0.140 |
R-HSA-194068 | Bile acid and bile salt metabolism | 0.727596 | 0.138 |
R-HSA-6803157 | Antimicrobial peptides | 0.730495 | 0.136 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.736202 | 0.133 |
R-HSA-388396 | GPCR downstream signalling | 0.744312 | 0.128 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.744538 | 0.128 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.744538 | 0.128 |
R-HSA-72312 | rRNA processing | 0.749387 | 0.125 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.757853 | 0.120 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.757853 | 0.120 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.762984 | 0.117 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.765509 | 0.116 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.765509 | 0.116 |
R-HSA-2132295 | MHC class II antigen presentation | 0.768007 | 0.115 |
R-HSA-162909 | Host Interactions of HIV factors | 0.770478 | 0.113 |
R-HSA-162582 | Signal Transduction | 0.772816 | 0.112 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.777737 | 0.109 |
R-HSA-114608 | Platelet degranulation | 0.780105 | 0.108 |
R-HSA-69481 | G2/M Checkpoints | 0.780105 | 0.108 |
R-HSA-1474165 | Reproduction | 0.789331 | 0.103 |
R-HSA-5576891 | Cardiac conduction | 0.791576 | 0.102 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.795996 | 0.099 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.796199 | 0.099 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.804559 | 0.094 |
R-HSA-163685 | Integration of energy metabolism | 0.804559 | 0.094 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.805061 | 0.094 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.806643 | 0.093 |
R-HSA-5358351 | Signaling by Hedgehog | 0.808705 | 0.092 |
R-HSA-9664407 | Parasite infection | 0.812764 | 0.090 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.812764 | 0.090 |
R-HSA-9664417 | Leishmania phagocytosis | 0.812764 | 0.090 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.814761 | 0.089 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.820627 | 0.086 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.822540 | 0.085 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.828429 | 0.082 |
R-HSA-372790 | Signaling by GPCR | 0.828671 | 0.082 |
R-HSA-9658195 | Leishmania infection | 0.831022 | 0.080 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.831022 | 0.080 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.832408 | 0.080 |
R-HSA-9609507 | Protein localization | 0.838876 | 0.076 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.842298 | 0.075 |
R-HSA-9610379 | HCMV Late Events | 0.845648 | 0.073 |
R-HSA-9711097 | Cellular response to starvation | 0.847296 | 0.072 |
R-HSA-1483257 | Phospholipid metabolism | 0.849517 | 0.071 |
R-HSA-9006936 | Signaling by TGFB family members | 0.850541 | 0.070 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.856825 | 0.067 |
R-HSA-5619102 | SLC transporter disorders | 0.861365 | 0.065 |
R-HSA-9679506 | SARS-CoV Infections | 0.863641 | 0.064 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.867197 | 0.062 |
R-HSA-72306 | tRNA processing | 0.867197 | 0.062 |
R-HSA-418555 | G alpha (s) signalling events | 0.868616 | 0.061 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.870021 | 0.060 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.871410 | 0.060 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.871410 | 0.060 |
R-HSA-5689880 | Ub-specific processing proteases | 0.871410 | 0.060 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.872785 | 0.059 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.874145 | 0.058 |
R-HSA-168255 | Influenza Infection | 0.879442 | 0.056 |
R-HSA-8957322 | Metabolism of steroids | 0.882117 | 0.054 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.883584 | 0.054 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.884517 | 0.053 |
R-HSA-1474244 | Extracellular matrix organization | 0.888949 | 0.051 |
R-HSA-983712 | Ion channel transport | 0.891735 | 0.050 |
R-HSA-9609690 | HCMV Early Events | 0.899590 | 0.046 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.903822 | 0.044 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.906878 | 0.042 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.906878 | 0.042 |
R-HSA-8951664 | Neddylation | 0.924117 | 0.034 |
R-HSA-199991 | Membrane Trafficking | 0.927709 | 0.033 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.931135 | 0.031 |
R-HSA-109582 | Hemostasis | 0.932674 | 0.030 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.936144 | 0.029 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.938107 | 0.028 |
R-HSA-1280218 | Adaptive Immune System | 0.940242 | 0.027 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.942678 | 0.026 |
R-HSA-418594 | G alpha (i) signalling events | 0.943384 | 0.025 |
R-HSA-9609646 | HCMV Infection | 0.944506 | 0.025 |
R-HSA-597592 | Post-translational protein modification | 0.950405 | 0.022 |
R-HSA-9711123 | Cellular response to chemical stress | 0.954315 | 0.020 |
R-HSA-195721 | Signaling by WNT | 0.966981 | 0.015 |
R-HSA-449147 | Signaling by Interleukins | 0.969462 | 0.013 |
R-HSA-5653656 | Vesicle-mediated transport | 0.978137 | 0.010 |
R-HSA-168249 | Innate Immune System | 0.978166 | 0.010 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.983871 | 0.007 |
R-HSA-9824446 | Viral Infection Pathways | 0.984798 | 0.007 |
R-HSA-168256 | Immune System | 0.990996 | 0.004 |
R-HSA-5668914 | Diseases of metabolism | 0.991972 | 0.004 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.992063 | 0.003 |
R-HSA-72766 | Translation | 0.992145 | 0.003 |
R-HSA-6798695 | Neutrophil degranulation | 0.994217 | 0.003 |
R-HSA-382551 | Transport of small molecules | 0.994655 | 0.002 |
R-HSA-5663205 | Infectious disease | 0.998299 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 0.998967 | 0.000 |
R-HSA-1643685 | Disease | 0.999287 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999947 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999986 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
KIS |
0.855 | 0.323 | 1 | 0.734 |
CLK3 |
0.851 | 0.277 | 1 | 0.825 |
HIPK4 |
0.848 | 0.350 | 1 | 0.821 |
COT |
0.847 | 0.120 | 2 | 0.822 |
MOS |
0.840 | 0.199 | 1 | 0.844 |
CDC7 |
0.839 | 0.074 | 1 | 0.814 |
SRPK1 |
0.836 | 0.172 | -3 | 0.720 |
GRK1 |
0.835 | 0.161 | -2 | 0.789 |
NDR2 |
0.835 | 0.124 | -3 | 0.832 |
PIM3 |
0.833 | 0.085 | -3 | 0.813 |
PRPK |
0.832 | 0.031 | -1 | 0.878 |
PRKD1 |
0.832 | 0.208 | -3 | 0.816 |
ERK5 |
0.830 | 0.141 | 1 | 0.822 |
DYRK2 |
0.830 | 0.225 | 1 | 0.773 |
MTOR |
0.829 | -0.011 | 1 | 0.720 |
ATR |
0.829 | 0.098 | 1 | 0.819 |
HIPK2 |
0.826 | 0.253 | 1 | 0.693 |
NLK |
0.826 | 0.074 | 1 | 0.818 |
GCN2 |
0.826 | -0.033 | 2 | 0.753 |
CDK19 |
0.826 | 0.182 | 1 | 0.668 |
CDKL5 |
0.826 | 0.108 | -3 | 0.774 |
SKMLCK |
0.825 | 0.097 | -2 | 0.846 |
CDK8 |
0.825 | 0.155 | 1 | 0.699 |
IKKB |
0.825 | -0.069 | -2 | 0.712 |
CHAK2 |
0.825 | 0.075 | -1 | 0.804 |
CLK2 |
0.825 | 0.208 | -3 | 0.698 |
BMPR1B |
0.825 | 0.166 | 1 | 0.764 |
BMPR2 |
0.824 | 0.015 | -2 | 0.881 |
CDKL1 |
0.824 | 0.066 | -3 | 0.777 |
TGFBR2 |
0.822 | 0.044 | -2 | 0.832 |
CDK1 |
0.822 | 0.158 | 1 | 0.685 |
DSTYK |
0.822 | -0.058 | 2 | 0.848 |
NEK6 |
0.821 | 0.034 | -2 | 0.869 |
IKKA |
0.820 | 0.043 | -2 | 0.708 |
SRPK2 |
0.820 | 0.112 | -3 | 0.647 |
PRKD2 |
0.820 | 0.125 | -3 | 0.737 |
ICK |
0.820 | 0.114 | -3 | 0.814 |
CAMK2G |
0.819 | -0.098 | 2 | 0.765 |
CDK18 |
0.819 | 0.188 | 1 | 0.660 |
CAMK1B |
0.819 | -0.041 | -3 | 0.813 |
RSK2 |
0.819 | 0.053 | -3 | 0.740 |
GRK5 |
0.819 | -0.067 | -3 | 0.841 |
PDHK4 |
0.818 | -0.246 | 1 | 0.776 |
TBK1 |
0.818 | -0.088 | 1 | 0.622 |
TGFBR1 |
0.818 | 0.124 | -2 | 0.835 |
SRPK3 |
0.818 | 0.101 | -3 | 0.695 |
RAF1 |
0.817 | -0.149 | 1 | 0.748 |
P38B |
0.817 | 0.197 | 1 | 0.694 |
HIPK1 |
0.817 | 0.208 | 1 | 0.778 |
CDK13 |
0.816 | 0.133 | 1 | 0.685 |
CDK5 |
0.816 | 0.153 | 1 | 0.729 |
IKKE |
0.816 | -0.096 | 1 | 0.618 |
GRK7 |
0.816 | 0.104 | 1 | 0.706 |
CDK7 |
0.816 | 0.127 | 1 | 0.711 |
MAPKAPK2 |
0.815 | 0.079 | -3 | 0.709 |
DYRK4 |
0.815 | 0.206 | 1 | 0.700 |
PIM1 |
0.815 | 0.047 | -3 | 0.751 |
LATS2 |
0.814 | 0.031 | -5 | 0.692 |
DAPK2 |
0.814 | 0.008 | -3 | 0.829 |
P38D |
0.814 | 0.214 | 1 | 0.635 |
NDR1 |
0.814 | -0.024 | -3 | 0.803 |
CAMLCK |
0.814 | -0.007 | -2 | 0.821 |
ULK2 |
0.814 | -0.164 | 2 | 0.725 |
PDHK1 |
0.814 | -0.167 | 1 | 0.758 |
MLK1 |
0.813 | -0.103 | 2 | 0.765 |
P90RSK |
0.813 | 0.033 | -3 | 0.741 |
CDK3 |
0.813 | 0.156 | 1 | 0.634 |
LATS1 |
0.813 | 0.139 | -3 | 0.846 |
CAMK2D |
0.813 | -0.003 | -3 | 0.810 |
NEK7 |
0.813 | -0.124 | -3 | 0.831 |
MARK4 |
0.813 | -0.024 | 4 | 0.832 |
CLK4 |
0.812 | 0.114 | -3 | 0.717 |
AURC |
0.812 | 0.071 | -2 | 0.626 |
P38A |
0.812 | 0.166 | 1 | 0.743 |
ATM |
0.812 | 0.037 | 1 | 0.765 |
ERK1 |
0.812 | 0.155 | 1 | 0.675 |
MAPKAPK3 |
0.811 | 0.038 | -3 | 0.750 |
P38G |
0.811 | 0.152 | 1 | 0.611 |
NIK |
0.811 | -0.095 | -3 | 0.833 |
NUAK2 |
0.811 | -0.039 | -3 | 0.791 |
FAM20C |
0.811 | 0.031 | 2 | 0.597 |
JNK2 |
0.810 | 0.146 | 1 | 0.660 |
JNK3 |
0.810 | 0.125 | 1 | 0.691 |
WNK1 |
0.810 | -0.069 | -2 | 0.866 |
ACVR2B |
0.810 | 0.090 | -2 | 0.826 |
PKN3 |
0.810 | -0.047 | -3 | 0.784 |
GRK6 |
0.810 | -0.076 | 1 | 0.777 |
ALK4 |
0.810 | 0.052 | -2 | 0.858 |
MST4 |
0.809 | -0.058 | 2 | 0.822 |
MLK2 |
0.809 | -0.008 | 2 | 0.776 |
CAMK2B |
0.808 | 0.020 | 2 | 0.747 |
GRK4 |
0.808 | -0.081 | -2 | 0.840 |
CDK12 |
0.808 | 0.122 | 1 | 0.662 |
RIPK3 |
0.808 | -0.154 | 3 | 0.580 |
CLK1 |
0.808 | 0.109 | -3 | 0.685 |
RSK3 |
0.808 | -0.000 | -3 | 0.727 |
MASTL |
0.808 | -0.179 | -2 | 0.810 |
ACVR2A |
0.807 | 0.064 | -2 | 0.819 |
CAMK2A |
0.807 | 0.023 | 2 | 0.764 |
CDK17 |
0.807 | 0.143 | 1 | 0.613 |
TLK2 |
0.807 | 0.079 | 1 | 0.735 |
BCKDK |
0.807 | -0.161 | -1 | 0.760 |
SMG1 |
0.807 | 0.039 | 1 | 0.780 |
PKACG |
0.806 | -0.021 | -2 | 0.706 |
ALK2 |
0.806 | 0.075 | -2 | 0.841 |
MLK3 |
0.806 | -0.022 | 2 | 0.689 |
HUNK |
0.806 | -0.172 | 2 | 0.758 |
PKCD |
0.806 | -0.013 | 2 | 0.727 |
DYRK1A |
0.804 | 0.139 | 1 | 0.760 |
AMPKA1 |
0.804 | -0.064 | -3 | 0.816 |
CDK9 |
0.804 | 0.095 | 1 | 0.692 |
PKACB |
0.804 | 0.060 | -2 | 0.638 |
PKN2 |
0.803 | -0.086 | -3 | 0.789 |
VRK2 |
0.803 | 0.004 | 1 | 0.833 |
BMPR1A |
0.803 | 0.095 | 1 | 0.742 |
P70S6KB |
0.803 | -0.039 | -3 | 0.753 |
NEK9 |
0.803 | -0.131 | 2 | 0.787 |
DLK |
0.803 | -0.155 | 1 | 0.758 |
HIPK3 |
0.803 | 0.162 | 1 | 0.756 |
TSSK1 |
0.803 | 0.001 | -3 | 0.836 |
DYRK1B |
0.802 | 0.145 | 1 | 0.714 |
PRP4 |
0.802 | 0.115 | -3 | 0.711 |
TSSK2 |
0.802 | -0.043 | -5 | 0.764 |
DNAPK |
0.801 | 0.058 | 1 | 0.671 |
PKR |
0.801 | -0.010 | 1 | 0.805 |
IRE1 |
0.801 | -0.084 | 1 | 0.762 |
ANKRD3 |
0.801 | -0.169 | 1 | 0.790 |
PKCB |
0.801 | -0.011 | 2 | 0.682 |
RSK4 |
0.800 | 0.033 | -3 | 0.718 |
ULK1 |
0.800 | -0.218 | -3 | 0.777 |
CDK2 |
0.800 | 0.039 | 1 | 0.748 |
QSK |
0.800 | -0.013 | 4 | 0.802 |
MPSK1 |
0.799 | 0.166 | 1 | 0.745 |
NIM1 |
0.799 | -0.105 | 3 | 0.635 |
AMPKA2 |
0.799 | -0.049 | -3 | 0.784 |
PKCA |
0.799 | -0.001 | 2 | 0.674 |
MAK |
0.798 | 0.210 | -2 | 0.747 |
DYRK3 |
0.798 | 0.124 | 1 | 0.790 |
MEK1 |
0.797 | -0.145 | 2 | 0.794 |
MSK2 |
0.797 | -0.037 | -3 | 0.731 |
WNK3 |
0.797 | -0.293 | 1 | 0.735 |
RIPK1 |
0.797 | -0.219 | 1 | 0.762 |
YSK4 |
0.797 | -0.087 | 1 | 0.672 |
PRKD3 |
0.797 | 0.013 | -3 | 0.698 |
MSK1 |
0.796 | 0.006 | -3 | 0.725 |
MLK4 |
0.796 | -0.085 | 2 | 0.668 |
CK1E |
0.796 | 0.022 | -3 | 0.581 |
PLK1 |
0.796 | -0.116 | -2 | 0.806 |
PAK1 |
0.796 | -0.051 | -2 | 0.750 |
CDK14 |
0.796 | 0.111 | 1 | 0.689 |
PRKX |
0.796 | 0.047 | -3 | 0.642 |
ERK2 |
0.795 | 0.067 | 1 | 0.705 |
MNK2 |
0.795 | -0.031 | -2 | 0.756 |
CHAK1 |
0.795 | -0.109 | 2 | 0.742 |
PASK |
0.794 | 0.071 | -3 | 0.844 |
PKCZ |
0.794 | -0.042 | 2 | 0.726 |
CK2A2 |
0.794 | 0.071 | 1 | 0.726 |
TTBK2 |
0.794 | -0.217 | 2 | 0.643 |
IRE2 |
0.794 | -0.091 | 2 | 0.681 |
PKCG |
0.793 | -0.068 | 2 | 0.678 |
CDK16 |
0.793 | 0.121 | 1 | 0.626 |
PKG2 |
0.793 | -0.000 | -2 | 0.634 |
PERK |
0.793 | -0.033 | -2 | 0.852 |
AURB |
0.792 | -0.008 | -2 | 0.624 |
GRK2 |
0.792 | -0.051 | -2 | 0.720 |
AURA |
0.792 | -0.002 | -2 | 0.605 |
PHKG1 |
0.792 | -0.080 | -3 | 0.791 |
PAK3 |
0.792 | -0.093 | -2 | 0.739 |
PIM2 |
0.792 | 0.014 | -3 | 0.705 |
JNK1 |
0.791 | 0.096 | 1 | 0.654 |
GSK3A |
0.791 | 0.053 | 4 | 0.468 |
CK1D |
0.791 | 0.041 | -3 | 0.534 |
MARK3 |
0.791 | -0.037 | 4 | 0.765 |
CDK10 |
0.791 | 0.099 | 1 | 0.681 |
AKT2 |
0.791 | 0.014 | -3 | 0.646 |
MNK1 |
0.790 | -0.035 | -2 | 0.761 |
QIK |
0.790 | -0.152 | -3 | 0.798 |
NEK2 |
0.790 | -0.116 | 2 | 0.769 |
PLK3 |
0.789 | -0.120 | 2 | 0.722 |
CAMK4 |
0.789 | -0.161 | -3 | 0.775 |
SIK |
0.789 | -0.064 | -3 | 0.723 |
SGK3 |
0.789 | -0.019 | -3 | 0.727 |
MYLK4 |
0.788 | -0.061 | -2 | 0.734 |
BUB1 |
0.788 | 0.279 | -5 | 0.718 |
NUAK1 |
0.788 | -0.092 | -3 | 0.738 |
DRAK1 |
0.788 | -0.095 | 1 | 0.709 |
MELK |
0.788 | -0.106 | -3 | 0.763 |
MARK2 |
0.787 | -0.064 | 4 | 0.741 |
PKCH |
0.787 | -0.098 | 2 | 0.661 |
TLK1 |
0.787 | -0.064 | -2 | 0.847 |
GSK3B |
0.787 | 0.001 | 4 | 0.460 |
MST3 |
0.787 | -0.035 | 2 | 0.804 |
NEK5 |
0.786 | -0.049 | 1 | 0.765 |
BRSK1 |
0.786 | -0.099 | -3 | 0.747 |
CHK1 |
0.785 | -0.056 | -3 | 0.800 |
MOK |
0.785 | 0.153 | 1 | 0.815 |
TAO3 |
0.785 | -0.034 | 1 | 0.714 |
PAK6 |
0.785 | -0.030 | -2 | 0.656 |
ERK7 |
0.785 | 0.053 | 2 | 0.522 |
PAK2 |
0.785 | -0.109 | -2 | 0.735 |
CK2A1 |
0.784 | 0.057 | 1 | 0.709 |
MEKK1 |
0.784 | -0.140 | 1 | 0.738 |
CK1A2 |
0.784 | 0.009 | -3 | 0.531 |
BRSK2 |
0.783 | -0.130 | -3 | 0.769 |
HRI |
0.783 | -0.165 | -2 | 0.855 |
DCAMKL1 |
0.783 | -0.053 | -3 | 0.737 |
MEK5 |
0.783 | -0.254 | 2 | 0.776 |
GAK |
0.783 | 0.013 | 1 | 0.798 |
ZAK |
0.783 | -0.152 | 1 | 0.699 |
MEKK2 |
0.783 | -0.141 | 2 | 0.750 |
PKACA |
0.782 | 0.016 | -2 | 0.587 |
GRK3 |
0.782 | -0.042 | -2 | 0.687 |
PLK4 |
0.782 | -0.140 | 2 | 0.559 |
PINK1 |
0.781 | -0.158 | 1 | 0.801 |
MAPKAPK5 |
0.781 | -0.111 | -3 | 0.696 |
CK1G1 |
0.780 | -0.035 | -3 | 0.555 |
MEKK3 |
0.780 | -0.230 | 1 | 0.729 |
WNK4 |
0.780 | -0.138 | -2 | 0.871 |
CDK6 |
0.780 | 0.086 | 1 | 0.669 |
MARK1 |
0.779 | -0.114 | 4 | 0.777 |
LKB1 |
0.778 | 0.004 | -3 | 0.810 |
BRAF |
0.778 | -0.190 | -4 | 0.782 |
DAPK3 |
0.777 | -0.010 | -3 | 0.753 |
CAMK1G |
0.777 | -0.097 | -3 | 0.710 |
SSTK |
0.777 | -0.063 | 4 | 0.790 |
GCK |
0.776 | -0.008 | 1 | 0.702 |
SMMLCK |
0.776 | -0.092 | -3 | 0.772 |
CDK4 |
0.776 | 0.080 | 1 | 0.654 |
CAMKK2 |
0.775 | -0.071 | -2 | 0.710 |
EEF2K |
0.775 | -0.047 | 3 | 0.712 |
TNIK |
0.775 | 0.014 | 3 | 0.773 |
PKCT |
0.775 | -0.089 | 2 | 0.668 |
SNRK |
0.775 | -0.249 | 2 | 0.628 |
MST2 |
0.775 | -0.071 | 1 | 0.719 |
CAMKK1 |
0.774 | -0.142 | -2 | 0.709 |
IRAK4 |
0.774 | -0.173 | 1 | 0.757 |
AKT1 |
0.774 | -0.018 | -3 | 0.665 |
PDHK3_TYR |
0.773 | 0.280 | 4 | 0.884 |
PDK1 |
0.773 | -0.106 | 1 | 0.710 |
PKCE |
0.772 | -0.041 | 2 | 0.667 |
TAO2 |
0.771 | -0.139 | 2 | 0.793 |
NEK11 |
0.771 | -0.201 | 1 | 0.695 |
VRK1 |
0.771 | -0.062 | 2 | 0.774 |
P70S6K |
0.771 | -0.077 | -3 | 0.673 |
DAPK1 |
0.770 | -0.029 | -3 | 0.739 |
HGK |
0.770 | -0.056 | 3 | 0.756 |
MINK |
0.770 | -0.072 | 1 | 0.692 |
NEK8 |
0.770 | -0.197 | 2 | 0.767 |
MAP3K15 |
0.770 | -0.066 | 1 | 0.676 |
PKCI |
0.769 | -0.098 | 2 | 0.691 |
PBK |
0.769 | 0.041 | 1 | 0.732 |
MEKK6 |
0.769 | -0.102 | 1 | 0.718 |
CAMK1D |
0.769 | -0.055 | -3 | 0.641 |
PLK2 |
0.769 | -0.058 | -3 | 0.738 |
HPK1 |
0.768 | -0.064 | 1 | 0.687 |
LRRK2 |
0.768 | -0.128 | 2 | 0.798 |
TAK1 |
0.767 | -0.133 | 1 | 0.714 |
KHS1 |
0.767 | 0.000 | 1 | 0.681 |
DCAMKL2 |
0.767 | -0.133 | -3 | 0.749 |
NEK1 |
0.766 | -0.065 | 1 | 0.734 |
ROCK2 |
0.766 | 0.013 | -3 | 0.748 |
OSR1 |
0.766 | 0.032 | 2 | 0.756 |
NEK4 |
0.766 | -0.151 | 1 | 0.713 |
MAP2K4_TYR |
0.765 | 0.145 | -1 | 0.886 |
PDHK4_TYR |
0.765 | 0.158 | 2 | 0.849 |
SGK1 |
0.765 | 0.001 | -3 | 0.579 |
AKT3 |
0.765 | -0.001 | -3 | 0.596 |
MAP2K6_TYR |
0.764 | 0.102 | -1 | 0.884 |
KHS2 |
0.764 | -0.015 | 1 | 0.694 |
PAK5 |
0.763 | -0.082 | -2 | 0.604 |
PHKG2 |
0.763 | -0.168 | -3 | 0.728 |
MST1 |
0.763 | -0.112 | 1 | 0.701 |
PKMYT1_TYR |
0.762 | 0.086 | 3 | 0.729 |
LOK |
0.761 | -0.082 | -2 | 0.726 |
PAK4 |
0.761 | -0.073 | -2 | 0.615 |
SBK |
0.761 | 0.024 | -3 | 0.528 |
SLK |
0.761 | -0.077 | -2 | 0.683 |
TTBK1 |
0.761 | -0.254 | 2 | 0.560 |
TESK1_TYR |
0.760 | 0.051 | 3 | 0.765 |
BMPR2_TYR |
0.759 | 0.037 | -1 | 0.886 |
PDHK1_TYR |
0.758 | 0.015 | -1 | 0.882 |
LIMK2_TYR |
0.758 | 0.116 | -3 | 0.860 |
CHK2 |
0.758 | -0.048 | -3 | 0.583 |
MRCKB |
0.757 | -0.046 | -3 | 0.687 |
STK33 |
0.757 | -0.184 | 2 | 0.558 |
CK1A |
0.757 | 0.004 | -3 | 0.445 |
MRCKA |
0.756 | -0.059 | -3 | 0.705 |
TTK |
0.756 | -0.041 | -2 | 0.844 |
IRAK1 |
0.756 | -0.368 | -1 | 0.719 |
ABL2 |
0.756 | 0.197 | -1 | 0.804 |
TXK |
0.756 | 0.126 | 1 | 0.815 |
MEK2 |
0.756 | -0.236 | 2 | 0.759 |
PKN1 |
0.755 | -0.096 | -3 | 0.680 |
YSK1 |
0.755 | -0.130 | 2 | 0.766 |
EPHB4 |
0.755 | 0.090 | -1 | 0.833 |
DMPK1 |
0.754 | -0.004 | -3 | 0.697 |
MAP2K7_TYR |
0.754 | -0.148 | 2 | 0.815 |
MYO3B |
0.754 | -0.010 | 2 | 0.782 |
EPHA6 |
0.753 | 0.041 | -1 | 0.853 |
CAMK1A |
0.753 | -0.051 | -3 | 0.601 |
HASPIN |
0.752 | -0.050 | -1 | 0.636 |
ABL1 |
0.751 | 0.170 | -1 | 0.794 |
BIKE |
0.750 | 0.011 | 1 | 0.691 |
LCK |
0.748 | 0.067 | -1 | 0.841 |
FGR |
0.748 | 0.020 | 1 | 0.799 |
PINK1_TYR |
0.747 | -0.210 | 1 | 0.778 |
ROCK1 |
0.747 | -0.034 | -3 | 0.703 |
YANK3 |
0.747 | -0.079 | 2 | 0.360 |
NEK3 |
0.747 | -0.161 | 1 | 0.683 |
BLK |
0.746 | 0.065 | -1 | 0.832 |
ALPHAK3 |
0.746 | -0.075 | -1 | 0.806 |
JAK2 |
0.745 | -0.021 | 1 | 0.723 |
RET |
0.745 | -0.072 | 1 | 0.735 |
ITK |
0.745 | 0.019 | -1 | 0.807 |
ASK1 |
0.745 | -0.131 | 1 | 0.660 |
EPHA4 |
0.745 | 0.015 | 2 | 0.733 |
RIPK2 |
0.745 | -0.343 | 1 | 0.647 |
FER |
0.745 | -0.046 | 1 | 0.817 |
CRIK |
0.745 | -0.011 | -3 | 0.677 |
ROS1 |
0.745 | -0.071 | 3 | 0.635 |
MST1R |
0.745 | -0.066 | 3 | 0.702 |
LIMK1_TYR |
0.745 | -0.126 | 2 | 0.800 |
PKG1 |
0.744 | -0.073 | -2 | 0.555 |
HCK |
0.744 | -0.008 | -1 | 0.839 |
CSF1R |
0.744 | -0.031 | 3 | 0.668 |
TYRO3 |
0.744 | -0.076 | 3 | 0.680 |
MYO3A |
0.744 | -0.111 | 1 | 0.714 |
SRMS |
0.743 | -0.012 | 1 | 0.799 |
TYK2 |
0.743 | -0.135 | 1 | 0.725 |
YES1 |
0.743 | -0.051 | -1 | 0.840 |
TNK2 |
0.742 | 0.004 | 3 | 0.625 |
BMX |
0.742 | 0.018 | -1 | 0.765 |
EPHB3 |
0.740 | 0.000 | -1 | 0.813 |
AAK1 |
0.740 | 0.073 | 1 | 0.603 |
EPHB2 |
0.740 | 0.012 | -1 | 0.808 |
EPHB1 |
0.740 | -0.039 | 1 | 0.791 |
TAO1 |
0.738 | -0.134 | 1 | 0.630 |
TNNI3K_TYR |
0.738 | 0.024 | 1 | 0.782 |
FYN |
0.738 | 0.027 | -1 | 0.836 |
MET |
0.738 | -0.008 | 3 | 0.678 |
JAK3 |
0.737 | -0.111 | 1 | 0.709 |
MERTK |
0.737 | -0.009 | 3 | 0.653 |
KIT |
0.736 | -0.072 | 3 | 0.666 |
DDR1 |
0.736 | -0.200 | 4 | 0.813 |
INSRR |
0.735 | -0.136 | 3 | 0.599 |
JAK1 |
0.735 | -0.037 | 1 | 0.654 |
STLK3 |
0.732 | -0.188 | 1 | 0.664 |
TEC |
0.732 | -0.075 | -1 | 0.744 |
PTK2B |
0.731 | 0.040 | -1 | 0.760 |
KDR |
0.731 | -0.112 | 3 | 0.617 |
WEE1_TYR |
0.730 | -0.060 | -1 | 0.768 |
FGFR2 |
0.730 | -0.175 | 3 | 0.647 |
EPHA7 |
0.730 | -0.054 | 2 | 0.725 |
TNK1 |
0.730 | -0.073 | 3 | 0.669 |
EPHA3 |
0.730 | -0.065 | 2 | 0.699 |
PTK2 |
0.730 | 0.063 | -1 | 0.818 |
LYN |
0.729 | -0.060 | 3 | 0.589 |
PTK6 |
0.729 | -0.129 | -1 | 0.745 |
FLT3 |
0.728 | -0.162 | 3 | 0.679 |
SYK |
0.728 | 0.060 | -1 | 0.814 |
TEK |
0.728 | -0.172 | 3 | 0.597 |
PDGFRB |
0.728 | -0.186 | 3 | 0.673 |
AXL |
0.728 | -0.119 | 3 | 0.639 |
BTK |
0.726 | -0.179 | -1 | 0.768 |
EPHA5 |
0.725 | -0.033 | 2 | 0.713 |
NEK10_TYR |
0.725 | -0.122 | 1 | 0.563 |
DDR2 |
0.725 | -0.053 | 3 | 0.575 |
SRC |
0.725 | -0.066 | -1 | 0.818 |
FGFR1 |
0.724 | -0.194 | 3 | 0.624 |
EPHA1 |
0.724 | -0.082 | 3 | 0.659 |
ALK |
0.724 | -0.153 | 3 | 0.582 |
NTRK3 |
0.724 | -0.089 | -1 | 0.792 |
EPHA8 |
0.723 | -0.054 | -1 | 0.803 |
FLT1 |
0.723 | -0.121 | -1 | 0.832 |
FRK |
0.723 | -0.100 | -1 | 0.825 |
LTK |
0.723 | -0.141 | 3 | 0.606 |
NTRK1 |
0.722 | -0.181 | -1 | 0.825 |
CK1G3 |
0.721 | -0.051 | -3 | 0.395 |
ERBB2 |
0.721 | -0.177 | 1 | 0.684 |
FGFR3 |
0.720 | -0.178 | 3 | 0.616 |
INSR |
0.720 | -0.168 | 3 | 0.589 |
MATK |
0.719 | -0.089 | -1 | 0.727 |
PDGFRA |
0.718 | -0.246 | 3 | 0.679 |
EGFR |
0.718 | -0.086 | 1 | 0.603 |
EPHA2 |
0.717 | -0.033 | -1 | 0.788 |
NTRK2 |
0.716 | -0.224 | 3 | 0.613 |
ZAP70 |
0.714 | 0.072 | -1 | 0.758 |
CSK |
0.714 | -0.136 | 2 | 0.728 |
FGFR4 |
0.713 | -0.107 | -1 | 0.782 |
FLT4 |
0.712 | -0.246 | 3 | 0.599 |
CK1G2 |
0.712 | -0.036 | -3 | 0.479 |
YANK2 |
0.710 | -0.116 | 2 | 0.374 |
ERBB4 |
0.709 | -0.070 | 1 | 0.638 |
IGF1R |
0.707 | -0.152 | 3 | 0.531 |
MUSK |
0.701 | -0.148 | 1 | 0.589 |
FES |
0.699 | -0.131 | -1 | 0.737 |