Motif 204 (n=167)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L390 | PLEKHG3 | S783 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NCI8 | C2orf78 | S819 | ochoa | Uncharacterized protein C2orf78 | None |
| A6NKD9 | CCDC85C | S246 | ochoa | Coiled-coil domain-containing protein 85C | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}. |
| A7KAX9 | ARHGAP32 | S1630 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| E7EW31 | PROB1 | S865 | ochoa | Proline-rich basic protein 1 | None |
| E9PAV3 | NACA | S1581 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| K7ENP7 | None | S20 | ochoa | INO80 complex subunit C | None |
| O00192 | ARVCF | S879 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14654 | IRS4 | S804 | psp | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14827 | RASGRF2 | S793 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
| O14964 | HGS | S310 | ochoa | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
| O15049 | N4BP3 | S176 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15049 | N4BP3 | S221 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15162 | PLSCR1 | Y69 | psp | Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b) | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:10770950, PubMed:18629440, PubMed:23590222, PubMed:23659204, PubMed:24343571, PubMed:24648509, PubMed:29748552, PubMed:32110987, PubMed:8663431, PubMed:9218461, PubMed:9485382, PubMed:9572851). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (PubMed:17567603, PubMed:27206388). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (By similarity). May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes (PubMed:15308695). Inhibits the functions of viral transactivators, including human T-cell leukemia virus (HTLV)-1 protein Tax, human immunodeficiency virus (HIV)-1 Tat, human hepatitis B virus (HBV) HBx, Epstein-Barr virus (EBV) BZLF1 and human cytomegalovirus IE1 and IE2 proteins through direct interactions (PubMed:22789739, PubMed:23501106, PubMed:25365352, PubMed:31434743, PubMed:35138119). Also mediates the inhibition of influenza virus infection by preventing nuclear import of the viral nucleoprotein/NP (PubMed:29352288, PubMed:35595813). Plays a crucial role as a defense factor against SARS-CoV-2 independently of its scramblase activity by directly targeting nascent viral vesicles to prevent virus-membrane fusion and the release of viral RNA into the host-cell cytosol (PubMed:37438530). {ECO:0000250|UniProtKB:Q9JJ00, ECO:0000269|PubMed:10770950, ECO:0000269|PubMed:15308695, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18629440, ECO:0000269|PubMed:21806988, ECO:0000269|PubMed:22789739, ECO:0000269|PubMed:23501106, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:23659204, ECO:0000269|PubMed:24343571, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:25365352, ECO:0000269|PubMed:26745724, ECO:0000269|PubMed:27206388, ECO:0000269|PubMed:29748552, ECO:0000269|PubMed:31434743, ECO:0000269|PubMed:32110987, ECO:0000269|PubMed:35138119, ECO:0000269|PubMed:37438530, ECO:0000269|PubMed:8663431, ECO:0000269|PubMed:9218461, ECO:0000269|PubMed:9485382, ECO:0000269|PubMed:9572851}.; FUNCTION: (Microbial infection) Acts as an attachment receptor for HCV. {ECO:0000269|PubMed:21806988}. |
| O43566 | RGS14 | S67 | ochoa | Regulator of G-protein signaling 14 (RGS14) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}. |
| O43602 | DCX | S304 | ochoa | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. {ECO:0000269|PubMed:22359282}. |
| O43847 | NRDC | S58 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60244 | MED14 | S1116 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O75152 | ZC3H11A | S759 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O95359 | TACC2 | S161 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P00519 | ABL1 | S1011 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P09874 | PARP1 | S385 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P12755 | SKI | S366 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P16383 | GCFC2 | S40 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P17600 | SYN1 | S568 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17936 | IGFBP3 | S148 | ochoa | Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}. |
| P21359 | NF1 | S2523 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P27816 | MAP4 | T900 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30872 | SSTR1 | S364 | ochoa | Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SST1) (SRIF-2) | Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. |
| P35568 | IRS1 | S1058 | psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35670 | ATP7B | S481 | psp | Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa] | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}. |
| P36871 | PGM1 | S134 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
| P40222 | TXLNA | S48 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P41440 | SLC19A1 | S515 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
| P43405 | SYK | S295 | psp | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P49790 | NUP153 | S164 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | S1764 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51608 | MECP2 | S68 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P52701 | MSH6 | S79 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P52735 | VAV2 | S663 | ochoa | Guanine nucleotide exchange factor VAV2 (VAV-2) | Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}. |
| P52948 | NUP98 | S1075 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P56524 | HDAC4 | S632 | ochoa|psp | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P78314 | SH3BP2 | S425 | ochoa | SH3 domain-binding protein 2 (3BP-2) | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. |
| P78347 | GTF2I | S710 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78559 | MAP1A | S1326 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P81408 | ENTREP3 | S469 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
| Q02086 | SP2 | S30 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q07157 | TJP1 | Y1199 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08211 | DHX9 | S321 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12802 | AKAP13 | S1363 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q13207 | TBX2 | S401 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13542 | EIF4EBP2 | S25 | ochoa | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957, ECO:0000269|PubMed:30765518}. |
| Q14126 | DSG2 | S939 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14157 | UBAP2L | S859 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14676 | MDC1 | S1732 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14738 | PPP2R5D | S60 | ochoa|psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14980 | NUMA1 | S1772 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
| Q15365 | PCBP1 | S246 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15942 | ZYX | S246 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q16555 | DPYSL2 | S537 | ochoa | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. |
| Q2KJY2 | KIF26B | S1033 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q53ET0 | CRTC2 | S516 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5H9R7 | PPP6R3 | S851 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5T035 | FAM120A2P | S45 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T0Z8 | C6orf132 | S575 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T5Y3 | CAMSAP1 | S431 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q66K74 | MAP1S | S900 | psp | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q69YH5 | CDCA2 | S614 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q69YU3 | ANKRD34A | S392 | ochoa | Ankyrin repeat domain-containing protein 34A | None |
| Q6NV74 | CRACDL | S315 | ochoa | CRACD-like protein | None |
| Q6NV74 | CRACDL | S316 | ochoa | CRACD-like protein | None |
| Q6P2E9 | EDC4 | S708 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PFW1 | PPIP5K1 | S1073 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6PI98 | INO80C | S20 | ochoa | INO80 complex subunit C (IES6 homolog) (hIes6) | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q6SPF0 | SAMD1 | S24 | ochoa | Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin) | Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor (PubMed:33980486). Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs (PubMed:33980486). Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (PubMed:16159594, PubMed:34006929). {ECO:0000269|PubMed:16159594, ECO:0000269|PubMed:33980486, ECO:0000269|PubMed:34006929}. |
| Q6UXY8 | TMC5 | S149 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q6WCQ1 | MPRIP | S377 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZUJ8 | PIK3AP1 | S562 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q7L2J0 | MEPCE | S353 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7LDG7 | RASGRP2 | S576 | ochoa | RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}. |
| Q7Z2K8 | GPRIN1 | S799 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2Z1 | TICRR | S1420 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3K3 | POGZ | S438 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z434 | MAVS | S408 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z5R6 | APBB1IP | S526 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q86UU0 | BCL9L | S1478 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86UU1 | PHLDB1 | S506 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86XK3 | SFR1 | S48 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q8IU81 | IRF2BP1 | S371 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IY63 | AMOTL1 | S809 | ochoa | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8IZT6 | ASPM | S240 | ochoa | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:15972725, ECO:0000269|PubMed:28436967}. |
| Q8N111 | CEND1 | S108 | ochoa | Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen) | Involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9JKC6}. |
| Q8N3F8 | MICALL1 | S589 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3J3 | HROB | S380 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N4C8 | MINK1 | S749 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N6F7 | GCSAM | S158 | ochoa | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| Q8NAX2 | KDF1 | S157 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
| Q8TBC5 | ZSCAN18 | S349 | ochoa | Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447) | May be involved in transcriptional regulation. |
| Q8TBZ3 | WDR20 | S441 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8TDC3 | BRSK1 | S430 | ochoa | Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. |
| Q8TE68 | EPS8L1 | T202 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TEC5 | SH3RF2 | S508 | ochoa | E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2) | Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436). {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}. |
| Q8TF72 | SHROOM3 | S1171 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF76 | HASPIN | S216 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WU20 | FRS2 | S161 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WU20 | FRS2 | S177 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
| Q8WUB8 | PHF10 | S27 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WX93 | PALLD | S725 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE0 | CASKIN2 | S393 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q92508 | PIEZO1 | S393 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92859 | NEO1 | S1268 | ochoa | Neogenin (Immunoglobulin superfamily DCC subclass member 2) | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}. |
| Q92997 | DVL3 | S116 | ochoa|psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q93052 | LPP | S246 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q96B18 | DACT3 | S520 | ochoa | Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3) | May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269|PubMed:18538736}. |
| Q96B97 | SH3KBP1 | S587 | ochoa|psp | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96CC6 | RHBDF1 | S49 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96CW6 | SLC7A6OS | S168 | ochoa | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q96CX2 | KCTD12 | S200 | ochoa|psp | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96D05 | FAM241B | S62 | ochoa | Protein FAM241B | May play a role in lysosome homeostasis. {ECO:0000269|PubMed:31270356}. |
| Q96IQ9 | ZNF414 | S68 | ochoa | Zinc finger protein 414 | May be involved in transcriptional regulation. |
| Q96RT7 | TUBGCP6 | S1304 | ochoa | Gamma-tubulin complex component 6 (GCP-6) | Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:11694571, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q99700 | ATXN2 | S675 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99704 | DOK1 | S313 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q9BRG2 | SH2D3A | S158 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BSJ8 | ESYT1 | S626 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9BVT8 | TMUB1 | S113 | ochoa | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3, ECO:0000269|PubMed:21343306}.; FUNCTION: [iHOPS]: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity). {ECO:0000250|UniProtKB:Q9JMG3}. |
| Q9C0C2 | TNKS1BP1 | S260 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1463 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZM8 | NDEL1 | S213 | ochoa | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9H0B6 | KLC2 | S589 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H3P2 | NELFA | S340 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H3S7 | PTPN23 | S1121 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H3S7 | PTPN23 | S1122 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H3T3 | SEMA6B | S802 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H8Y8 | GORASP2 | S408 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HBL0 | TNS1 | S1413 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9NQ84 | GPRC5C | S368 | ochoa | G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) | This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}. |
| Q9NQC3 | RTN4 | S107 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NUE0 | ZDHHC18 | S59 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NZB2 | FAM120A | S396 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9NZN8 | CNOT2 | S99 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
| Q9NZT2 | OGFR | S361 | ochoa | Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor) | Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. |
| Q9P0Z9 | PIPOX | S300 | ochoa | Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) | Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}. |
| Q9P219 | CCDC88C | S1778 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P244 | LRFN1 | S705 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P2J2 | IGSF9 | S797 | ochoa | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}. |
| Q9UBW5 | BIN2 | S357 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UBY9 | HSPB7 | S54 | ochoa | Heat shock protein beta-7 (HspB7) (Cardiovascular heat shock protein) (cvHsp) | None |
| Q9UJM3 | ERRFI1 | Y341 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9ULV3 | CIZ1 | S265 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMS6 | SYNPO2 | S155 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMS6 | SYNPO2 | S1064 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPN4 | CEP131 | S47 | ochoa|psp | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9Y2W2 | WBP11 | S600 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y2Y9 | KLF13 | S268 | ochoa | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y4H2 | IRS2 | S804 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y5U2 | TSSC4 | S93 | ochoa | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
| Q9Y613 | FHOD1 | S510 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y6R0 | NUMBL | S305 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| P29401 | TKT | S308 | Sugiyama | Transketolase (TK) (EC 2.2.1.1) | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000269|PubMed:27259054}. |
| O75676 | RPS6KA4 | S402 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| P00519 | ABL1 | S642 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| O15357 | INPPL1 | S189 | Sugiyama | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| Q99759 | MAP3K3 | S197 | iPTMNet|EPSD | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| P42566 | EPS15 | S655 | Sugiyama | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| Q9NQU5 | PAK6 | S301 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| P42679 | MATK | S484 | Sugiyama | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. {ECO:0000269|PubMed:9171348}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.000060 | 4.221 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.000068 | 4.166 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.000068 | 4.166 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.000087 | 4.059 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.000087 | 4.059 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.000098 | 4.008 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.000123 | 3.910 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.000187 | 3.728 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.000206 | 3.685 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.000153 | 3.817 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.000098 | 4.008 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.000110 | 3.958 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000206 | 3.685 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.000206 | 3.685 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000169 | 3.772 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.000187 | 3.728 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.000227 | 3.643 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000245 | 3.611 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000334 | 3.477 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.000357 | 3.448 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.000388 | 3.411 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.000499 | 3.302 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.000544 | 3.264 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000578 | 3.238 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.000889 | 3.051 |
| R-HSA-68875 | Mitotic Prophase | 0.000854 | 3.069 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.000993 | 3.003 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.001037 | 2.984 |
| R-HSA-191859 | snRNP Assembly | 0.001016 | 2.993 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.001016 | 2.993 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.001157 | 2.937 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.001232 | 2.909 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.001344 | 2.872 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.001497 | 2.825 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.001497 | 2.825 |
| R-HSA-70171 | Glycolysis | 0.001681 | 2.774 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.002140 | 2.670 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.002142 | 2.669 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.002197 | 2.658 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.002572 | 2.590 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.002892 | 2.539 |
| R-HSA-74713 | IRS activation | 0.002892 | 2.539 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.002892 | 2.539 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.002914 | 2.535 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.003007 | 2.522 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.003452 | 2.462 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.003612 | 2.442 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.003749 | 2.426 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003749 | 2.426 |
| R-HSA-70326 | Glucose metabolism | 0.003788 | 2.422 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.005773 | 2.239 |
| R-HSA-112412 | SOS-mediated signalling | 0.005773 | 2.239 |
| R-HSA-68886 | M Phase | 0.006011 | 2.221 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.006935 | 2.159 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.009546 | 2.020 |
| R-HSA-198203 | PI3K/AKT activation | 0.009546 | 2.020 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.007853 | 2.105 |
| R-HSA-74749 | Signal attenuation | 0.009546 | 2.020 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.009075 | 2.042 |
| R-HSA-182971 | EGFR downregulation | 0.008572 | 2.067 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.009509 | 2.022 |
| R-HSA-2586552 | Signaling by Leptin | 0.009546 | 2.020 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.009225 | 2.035 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.009676 | 2.014 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.009676 | 2.014 |
| R-HSA-354192 | Integrin signaling | 0.009877 | 2.005 |
| R-HSA-68877 | Mitotic Prometaphase | 0.010335 | 1.986 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.012525 | 1.902 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.011333 | 1.946 |
| R-HSA-8853659 | RET signaling | 0.012819 | 1.892 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.011333 | 1.946 |
| R-HSA-211000 | Gene Silencing by RNA | 0.011333 | 1.946 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.013756 | 1.862 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.014147 | 1.849 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.014147 | 1.849 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.014147 | 1.849 |
| R-HSA-9610379 | HCMV Late Events | 0.014476 | 1.839 |
| R-HSA-162587 | HIV Life Cycle | 0.014476 | 1.839 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.015309 | 1.815 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.016399 | 1.785 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.017647 | 1.753 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.019572 | 1.708 |
| R-HSA-1640170 | Cell Cycle | 0.017443 | 1.758 |
| R-HSA-3371556 | Cellular response to heat stress | 0.018505 | 1.733 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.020120 | 1.696 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.021873 | 1.660 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.021873 | 1.660 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.022109 | 1.655 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.022150 | 1.655 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.022315 | 1.651 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.023504 | 1.629 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.024238 | 1.616 |
| R-HSA-2028269 | Signaling by Hippo | 0.025610 | 1.592 |
| R-HSA-109704 | PI3K Cascade | 0.027890 | 1.555 |
| R-HSA-168255 | Influenza Infection | 0.024716 | 1.607 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.030122 | 1.521 |
| R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 0.032981 | 1.482 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.032981 | 1.482 |
| R-HSA-9635644 | Inhibition of membrane repair | 0.032981 | 1.482 |
| R-HSA-9609690 | HCMV Early Events | 0.034819 | 1.458 |
| R-HSA-177929 | Signaling by EGFR | 0.035721 | 1.447 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.035721 | 1.447 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.035843 | 1.446 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.036853 | 1.434 |
| R-HSA-112399 | IRS-mediated signalling | 0.037125 | 1.430 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.037208 | 1.429 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.043733 | 1.359 |
| R-HSA-429947 | Deadenylation of mRNA | 0.044957 | 1.347 |
| R-HSA-983189 | Kinesins | 0.041505 | 1.382 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.040017 | 1.398 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.039728 | 1.401 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.047661 | 1.322 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.042312 | 1.374 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.047730 | 1.321 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.047856 | 1.320 |
| R-HSA-525793 | Myogenesis | 0.050423 | 1.297 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.053241 | 1.274 |
| R-HSA-422475 | Axon guidance | 0.054318 | 1.265 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.054365 | 1.265 |
| R-HSA-5619102 | SLC transporter disorders | 0.057915 | 1.237 |
| R-HSA-373760 | L1CAM interactions | 0.059150 | 1.228 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.059963 | 1.222 |
| R-HSA-162906 | HIV Infection | 0.060296 | 1.220 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.075279 | 1.123 |
| R-HSA-191650 | Regulation of gap junction activity | 0.064880 | 1.188 |
| R-HSA-2424491 | DAP12 signaling | 0.062019 | 1.207 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.074418 | 1.128 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.064880 | 1.188 |
| R-HSA-8866376 | Reelin signalling pathway | 0.075279 | 1.123 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.065986 | 1.181 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.064880 | 1.188 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.075279 | 1.123 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.068124 | 1.167 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.065876 | 1.181 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.080889 | 1.092 |
| R-HSA-162582 | Signal Transduction | 0.081612 | 1.088 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.077739 | 1.109 |
| R-HSA-9675108 | Nervous system development | 0.077201 | 1.112 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.062019 | 1.207 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.072832 | 1.138 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.063294 | 1.199 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.068124 | 1.167 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.061836 | 1.209 |
| R-HSA-6806834 | Signaling by MET | 0.076817 | 1.115 |
| R-HSA-72306 | tRNA processing | 0.062269 | 1.206 |
| R-HSA-9609646 | HCMV Infection | 0.084038 | 1.076 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.084189 | 1.075 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.084189 | 1.075 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.087187 | 1.060 |
| R-HSA-201556 | Signaling by ALK | 0.094323 | 1.025 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.095733 | 1.019 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.095733 | 1.019 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.105790 | 0.976 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.105790 | 0.976 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.125573 | 0.901 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.135300 | 0.869 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.144920 | 0.839 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.144920 | 0.839 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.144920 | 0.839 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.144920 | 0.839 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.154434 | 0.811 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.163842 | 0.786 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.163842 | 0.786 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.163842 | 0.786 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.163842 | 0.786 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.163842 | 0.786 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.163842 | 0.786 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.191446 | 0.718 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.191446 | 0.718 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.200445 | 0.698 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.218144 | 0.661 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.235454 | 0.628 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.243965 | 0.613 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.260707 | 0.584 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.095885 | 1.018 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.196818 | 0.706 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.229414 | 0.639 |
| R-HSA-380287 | Centrosome maturation | 0.237626 | 0.624 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.216435 | 0.665 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 0.235454 | 0.628 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 0.243965 | 0.613 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.268938 | 0.570 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.243965 | 0.613 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.260707 | 0.584 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.268938 | 0.570 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.163842 | 0.786 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.218144 | 0.661 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.274709 | 0.561 |
| R-HSA-72172 | mRNA Splicing | 0.242504 | 0.615 |
| R-HSA-163754 | Insulin effects increased synthesis of Xylulose-5-Phosphate | 0.105790 | 0.976 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.200445 | 0.698 |
| R-HSA-9664420 | Killing mechanisms | 0.200445 | 0.698 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.172793 | 0.762 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.182347 | 0.739 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.269016 | 0.570 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.101265 | 0.995 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.260707 | 0.584 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.209344 | 0.679 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.115737 | 0.937 |
| R-HSA-192814 | vRNA Synthesis | 0.144920 | 0.839 |
| R-HSA-4839744 | Signaling by APC mutants | 0.144920 | 0.839 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.154434 | 0.811 |
| R-HSA-202670 | ERKs are inactivated | 0.154434 | 0.811 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.154434 | 0.811 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.154434 | 0.811 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.226847 | 0.644 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.226847 | 0.644 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.268938 | 0.570 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.285130 | 0.545 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.204918 | 0.688 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.182347 | 0.739 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.235454 | 0.628 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.109563 | 0.960 |
| R-HSA-5358508 | Mismatch Repair | 0.226847 | 0.644 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.105790 | 0.976 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.191446 | 0.718 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.268938 | 0.570 |
| R-HSA-170968 | Frs2-mediated activation | 0.173146 | 0.762 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.125573 | 0.901 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.173146 | 0.762 |
| R-HSA-2172127 | DAP12 interactions | 0.115549 | 0.937 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.144920 | 0.839 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.173146 | 0.762 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.182347 | 0.739 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.209344 | 0.679 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.257026 | 0.590 |
| R-HSA-9664407 | Parasite infection | 0.257026 | 0.590 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.257026 | 0.590 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.233718 | 0.631 |
| R-HSA-9842663 | Signaling by LTK | 0.163842 | 0.786 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.191446 | 0.718 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.107233 | 0.970 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.191217 | 0.718 |
| R-HSA-169893 | Prolonged ERK activation events | 0.200445 | 0.698 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.115737 | 0.937 |
| R-HSA-428540 | Activation of RAC1 | 0.154434 | 0.811 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.163842 | 0.786 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.191446 | 0.718 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.200445 | 0.698 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.148125 | 0.829 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.260017 | 0.585 |
| R-HSA-68882 | Mitotic Anaphase | 0.271702 | 0.566 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.274164 | 0.562 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.138968 | 0.857 |
| R-HSA-445144 | Signal transduction by L1 | 0.243965 | 0.613 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.119076 | 0.924 |
| R-HSA-449836 | Other interleukin signaling | 0.235454 | 0.628 |
| R-HSA-70370 | Galactose catabolism | 0.209344 | 0.679 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.277079 | 0.557 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.174390 | 0.758 |
| R-HSA-8953854 | Metabolism of RNA | 0.163628 | 0.786 |
| R-HSA-447043 | Neurofascin interactions | 0.095733 | 1.019 |
| R-HSA-392517 | Rap1 signalling | 0.235454 | 0.628 |
| R-HSA-198753 | ERK/MAPK targets | 0.252383 | 0.598 |
| R-HSA-437239 | Recycling pathway of L1 | 0.126576 | 0.898 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.119203 | 0.924 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.277079 | 0.557 |
| R-HSA-74160 | Gene expression (Transcription) | 0.166806 | 0.778 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.279461 | 0.554 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.160974 | 0.793 |
| R-HSA-212436 | Generic Transcription Pathway | 0.227163 | 0.644 |
| R-HSA-5635838 | Activation of SMO | 0.200445 | 0.698 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.226847 | 0.644 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.230357 | 0.638 |
| R-HSA-5693538 | Homology Directed Repair | 0.184489 | 0.734 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.144920 | 0.839 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.108343 | 0.965 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.260707 | 0.584 |
| R-HSA-166520 | Signaling by NTRKs | 0.116807 | 0.933 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.217134 | 0.663 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.201751 | 0.695 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.173512 | 0.761 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.226847 | 0.644 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.235454 | 0.628 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 0.252383 | 0.598 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.260707 | 0.584 |
| R-HSA-9833482 | PKR-mediated signaling | 0.258216 | 0.588 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.130306 | 0.885 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.097776 | 1.010 |
| R-HSA-3322077 | Glycogen synthesis | 0.243965 | 0.613 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.237626 | 0.624 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.121653 | 0.915 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.165924 | 0.780 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.165971 | 0.780 |
| R-HSA-75153 | Apoptotic execution phase | 0.122872 | 0.911 |
| R-HSA-73887 | Death Receptor Signaling | 0.128185 | 0.892 |
| R-HSA-9679506 | SARS-CoV Infections | 0.197811 | 0.704 |
| R-HSA-913531 | Interferon Signaling | 0.168548 | 0.773 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.179327 | 0.746 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.164897 | 0.783 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.277635 | 0.557 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.180716 | 0.743 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 0.293091 | 0.533 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.293091 | 0.533 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.293091 | 0.533 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.293091 | 0.533 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 0.293091 | 0.533 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.296206 | 0.528 |
| R-HSA-449147 | Signaling by Interleukins | 0.297966 | 0.526 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.299240 | 0.524 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.300964 | 0.521 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.300964 | 0.521 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.300964 | 0.521 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.308750 | 0.510 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.308750 | 0.510 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.308750 | 0.510 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.308750 | 0.510 |
| R-HSA-201451 | Signaling by BMP | 0.308750 | 0.510 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.314432 | 0.502 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.316450 | 0.500 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.316450 | 0.500 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.316450 | 0.500 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.316450 | 0.500 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.316450 | 0.500 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.316450 | 0.500 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.316450 | 0.500 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.316450 | 0.500 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.324064 | 0.489 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.324064 | 0.489 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.324064 | 0.489 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.324064 | 0.489 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.324064 | 0.489 |
| R-HSA-180024 | DARPP-32 events | 0.324064 | 0.489 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.324064 | 0.489 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.331594 | 0.479 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.331594 | 0.479 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.339041 | 0.470 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.339041 | 0.470 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.340235 | 0.468 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.346405 | 0.460 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.353688 | 0.451 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.353688 | 0.451 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.353688 | 0.451 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.353688 | 0.451 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.353688 | 0.451 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.353688 | 0.451 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.360386 | 0.443 |
| R-HSA-390522 | Striated Muscle Contraction | 0.360889 | 0.443 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.360889 | 0.443 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.360889 | 0.443 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.366085 | 0.436 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.368012 | 0.434 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.368012 | 0.434 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.368012 | 0.434 |
| R-HSA-5673000 | RAF activation | 0.368012 | 0.434 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.368385 | 0.434 |
| R-HSA-5688426 | Deubiquitination | 0.369471 | 0.432 |
| R-HSA-9833110 | RSV-host interactions | 0.372370 | 0.429 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.375055 | 0.426 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.375055 | 0.426 |
| R-HSA-187687 | Signalling to ERKs | 0.375055 | 0.426 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.376345 | 0.424 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.380333 | 0.420 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.382020 | 0.418 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.382020 | 0.418 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.388908 | 0.410 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.388908 | 0.410 |
| R-HSA-4641258 | Degradation of DVL | 0.388908 | 0.410 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.388908 | 0.410 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.388908 | 0.410 |
| R-HSA-71064 | Lysine catabolism | 0.388908 | 0.410 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.388908 | 0.410 |
| R-HSA-69275 | G2/M Transition | 0.402200 | 0.396 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.402455 | 0.395 |
| R-HSA-71336 | Pentose phosphate pathway | 0.402455 | 0.395 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.402455 | 0.395 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.403868 | 0.394 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.408168 | 0.389 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.409116 | 0.388 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.409116 | 0.388 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.409116 | 0.388 |
| R-HSA-167169 | HIV Transcription Elongation | 0.409116 | 0.388 |
| R-HSA-8982491 | Glycogen metabolism | 0.409116 | 0.388 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.411627 | 0.385 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.411627 | 0.385 |
| R-HSA-109582 | Hemostasis | 0.412336 | 0.385 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.415704 | 0.381 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.415704 | 0.381 |
| R-HSA-9607240 | FLT3 Signaling | 0.415704 | 0.381 |
| R-HSA-73894 | DNA Repair | 0.419995 | 0.377 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.422218 | 0.374 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.422218 | 0.374 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.422218 | 0.374 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.422218 | 0.374 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.423173 | 0.373 |
| R-HSA-9658195 | Leishmania infection | 0.434639 | 0.362 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.434639 | 0.362 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.435031 | 0.361 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.435031 | 0.361 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.435031 | 0.361 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.438385 | 0.358 |
| R-HSA-373752 | Netrin-1 signaling | 0.441331 | 0.355 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.441331 | 0.355 |
| R-HSA-69236 | G1 Phase | 0.441331 | 0.355 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.443572 | 0.353 |
| R-HSA-1643685 | Disease | 0.445358 | 0.351 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.445909 | 0.351 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.447562 | 0.349 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.452299 | 0.345 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.453377 | 0.344 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.453377 | 0.344 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.453723 | 0.343 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.453723 | 0.343 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.453723 | 0.343 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.453723 | 0.343 |
| R-HSA-9675135 | Diseases of DNA repair | 0.453723 | 0.343 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.459816 | 0.337 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.464472 | 0.333 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.464472 | 0.333 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.465841 | 0.332 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.465841 | 0.332 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.471799 | 0.326 |
| R-HSA-9766229 | Degradation of CDH1 | 0.471799 | 0.326 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.471799 | 0.326 |
| R-HSA-199991 | Membrane Trafficking | 0.473635 | 0.325 |
| R-HSA-195721 | Signaling by WNT | 0.476289 | 0.322 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.477691 | 0.321 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.477691 | 0.321 |
| R-HSA-9748787 | Azathioprine ADME | 0.477691 | 0.321 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.483518 | 0.316 |
| R-HSA-72187 | mRNA 3'-end processing | 0.489281 | 0.310 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.489281 | 0.310 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.489281 | 0.310 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.494979 | 0.305 |
| R-HSA-163685 | Integration of energy metabolism | 0.510977 | 0.292 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.511697 | 0.291 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.514444 | 0.289 |
| R-HSA-5621480 | Dectin-2 family | 0.517147 | 0.286 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.517147 | 0.286 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.517895 | 0.286 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.519890 | 0.284 |
| R-HSA-9824446 | Viral Infection Pathways | 0.521792 | 0.283 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.522536 | 0.282 |
| R-HSA-9033241 | Peroxisomal protein import | 0.527865 | 0.277 |
| R-HSA-180786 | Extension of Telomeres | 0.527865 | 0.277 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.533136 | 0.273 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.533136 | 0.273 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.533136 | 0.273 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.533136 | 0.273 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.533136 | 0.273 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.533136 | 0.273 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.538347 | 0.269 |
| R-HSA-450294 | MAP kinase activation | 0.538347 | 0.269 |
| R-HSA-9707616 | Heme signaling | 0.543501 | 0.265 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.543501 | 0.265 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.548597 | 0.261 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.548597 | 0.261 |
| R-HSA-373755 | Semaphorin interactions | 0.548597 | 0.261 |
| R-HSA-8848021 | Signaling by PTK6 | 0.548597 | 0.261 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.548597 | 0.261 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.553637 | 0.257 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.561263 | 0.251 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.561263 | 0.251 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.563550 | 0.249 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.564482 | 0.248 |
| R-HSA-167172 | Transcription of the HIV genome | 0.573244 | 0.242 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.573244 | 0.242 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.574038 | 0.241 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.582723 | 0.235 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.582723 | 0.235 |
| R-HSA-448424 | Interleukin-17 signaling | 0.582723 | 0.235 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.587384 | 0.231 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.591993 | 0.228 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.591993 | 0.228 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.592693 | 0.227 |
| R-HSA-109581 | Apoptosis | 0.598776 | 0.223 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.601059 | 0.221 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.601059 | 0.221 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.601059 | 0.221 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.605516 | 0.218 |
| R-HSA-5689603 | UCH proteinases | 0.609924 | 0.215 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.609924 | 0.215 |
| R-HSA-4086400 | PCP/CE pathway | 0.618593 | 0.209 |
| R-HSA-9659379 | Sensory processing of sound | 0.622855 | 0.206 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.627070 | 0.203 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.627070 | 0.203 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.627070 | 0.203 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.631238 | 0.200 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.631238 | 0.200 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.633843 | 0.198 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.633843 | 0.198 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.633843 | 0.198 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.643467 | 0.191 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.643467 | 0.191 |
| R-HSA-5663205 | Infectious disease | 0.643707 | 0.191 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.647453 | 0.189 |
| R-HSA-446728 | Cell junction organization | 0.649239 | 0.188 |
| R-HSA-2559583 | Cellular Senescence | 0.653176 | 0.185 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.658003 | 0.182 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.659147 | 0.181 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.670455 | 0.174 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.670455 | 0.174 |
| R-HSA-73884 | Base Excision Repair | 0.670455 | 0.174 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.681390 | 0.167 |
| R-HSA-2029481 | FCGR activation | 0.684954 | 0.164 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.691964 | 0.160 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.694320 | 0.158 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.698818 | 0.156 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.698818 | 0.156 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.698818 | 0.156 |
| R-HSA-157579 | Telomere Maintenance | 0.702189 | 0.154 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.702189 | 0.154 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.705521 | 0.151 |
| R-HSA-190236 | Signaling by FGFR | 0.705521 | 0.151 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.705521 | 0.151 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.705521 | 0.151 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.705521 | 0.151 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.711022 | 0.148 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.712992 | 0.147 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.715299 | 0.146 |
| R-HSA-5357801 | Programmed Cell Death | 0.717944 | 0.144 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.718486 | 0.144 |
| R-HSA-1483255 | PI Metabolism | 0.718486 | 0.144 |
| R-HSA-111885 | Opioid Signalling | 0.724753 | 0.140 |
| R-HSA-1500931 | Cell-Cell communication | 0.726943 | 0.138 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.727835 | 0.138 |
| R-HSA-2262752 | Cellular responses to stress | 0.730626 | 0.136 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.730882 | 0.136 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.733895 | 0.134 |
| R-HSA-418346 | Platelet homeostasis | 0.733895 | 0.134 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.735729 | 0.133 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.739822 | 0.131 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.742735 | 0.129 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.745617 | 0.127 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.745617 | 0.127 |
| R-HSA-418990 | Adherens junctions interactions | 0.746355 | 0.127 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.754070 | 0.123 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.759549 | 0.119 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.762243 | 0.118 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.764907 | 0.116 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.764907 | 0.116 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.770146 | 0.113 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.775269 | 0.111 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.775269 | 0.111 |
| R-HSA-73886 | Chromosome Maintenance | 0.780279 | 0.108 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.780279 | 0.108 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.782742 | 0.106 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.782742 | 0.106 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.787586 | 0.104 |
| R-HSA-388396 | GPCR downstream signalling | 0.789579 | 0.103 |
| R-HSA-194138 | Signaling by VEGF | 0.792322 | 0.101 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.794651 | 0.100 |
| R-HSA-114608 | Platelet degranulation | 0.796954 | 0.099 |
| R-HSA-69481 | G2/M Checkpoints | 0.796954 | 0.099 |
| R-HSA-421270 | Cell-cell junction organization | 0.807693 | 0.093 |
| R-HSA-9843745 | Adipogenesis | 0.808088 | 0.093 |
| R-HSA-9909396 | Circadian clock | 0.810241 | 0.091 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.812370 | 0.090 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.820650 | 0.086 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.833864 | 0.079 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.837976 | 0.077 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.840301 | 0.076 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.841595 | 0.075 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.843373 | 0.074 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.845132 | 0.073 |
| R-HSA-597592 | Post-translational protein modification | 0.852718 | 0.069 |
| R-HSA-9609507 | Protein localization | 0.853637 | 0.069 |
| R-HSA-1989781 | PPARA activates gene expression | 0.856907 | 0.067 |
| R-HSA-418594 | G alpha (i) signalling events | 0.859522 | 0.066 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.860105 | 0.065 |
| R-HSA-372790 | Signaling by GPCR | 0.864889 | 0.063 |
| R-HSA-168256 | Immune System | 0.871418 | 0.060 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.881928 | 0.055 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.884569 | 0.053 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.884569 | 0.053 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.887151 | 0.052 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.895186 | 0.048 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.897990 | 0.047 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.897990 | 0.047 |
| R-HSA-3781865 | Diseases of glycosylation | 0.898080 | 0.047 |
| R-HSA-1266738 | Developmental Biology | 0.898163 | 0.047 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.900362 | 0.046 |
| R-HSA-983712 | Ion channel transport | 0.903690 | 0.044 |
| R-HSA-5617833 | Cilium Assembly | 0.904774 | 0.043 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.905847 | 0.043 |
| R-HSA-112316 | Neuronal System | 0.912840 | 0.040 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.916879 | 0.038 |
| R-HSA-6805567 | Keratinization | 0.921459 | 0.036 |
| R-HSA-397014 | Muscle contraction | 0.926625 | 0.033 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.926625 | 0.033 |
| R-HSA-9748784 | Drug ADME | 0.931453 | 0.031 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.940181 | 0.027 |
| R-HSA-168249 | Innate Immune System | 0.941050 | 0.026 |
| R-HSA-157118 | Signaling by NOTCH | 0.946603 | 0.024 |
| R-HSA-4839726 | Chromatin organization | 0.951795 | 0.021 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.955483 | 0.020 |
| R-HSA-1280218 | Adaptive Immune System | 0.957453 | 0.019 |
| R-HSA-416476 | G alpha (q) signalling events | 0.959355 | 0.018 |
| R-HSA-6798695 | Neutrophil degranulation | 0.971310 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 0.971447 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.981068 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.987020 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.990902 | 0.004 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.993404 | 0.003 |
| R-HSA-5668914 | Diseases of metabolism | 0.993772 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.997641 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.999042 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999317 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999877 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.868 | 0.367 | 1 | 0.796 |
CLK3 |
0.867 | 0.310 | 1 | 0.799 |
PRKD1 |
0.866 | 0.351 | -3 | 0.885 |
SRPK1 |
0.865 | 0.353 | -3 | 0.889 |
COT |
0.862 | 0.149 | 2 | 0.838 |
PRKD2 |
0.862 | 0.334 | -3 | 0.865 |
PIM3 |
0.861 | 0.273 | -3 | 0.909 |
RSK2 |
0.861 | 0.316 | -3 | 0.888 |
CDKL1 |
0.860 | 0.340 | -3 | 0.917 |
NDR2 |
0.859 | 0.212 | -3 | 0.881 |
CDKL5 |
0.859 | 0.328 | -3 | 0.910 |
SKMLCK |
0.859 | 0.326 | -2 | 0.863 |
P90RSK |
0.857 | 0.302 | -3 | 0.892 |
CAMK2D |
0.857 | 0.290 | -3 | 0.897 |
ICK |
0.856 | 0.351 | -3 | 0.925 |
SRPK2 |
0.856 | 0.328 | -3 | 0.842 |
MTOR |
0.855 | 0.119 | 1 | 0.819 |
RSK3 |
0.855 | 0.291 | -3 | 0.881 |
MAPKAPK2 |
0.855 | 0.313 | -3 | 0.843 |
PIM1 |
0.855 | 0.302 | -3 | 0.893 |
DYRK2 |
0.854 | 0.272 | 1 | 0.725 |
CAMK1B |
0.854 | 0.254 | -3 | 0.926 |
MAPKAPK3 |
0.853 | 0.292 | -3 | 0.862 |
CLK2 |
0.853 | 0.370 | -3 | 0.876 |
CDC7 |
0.853 | 0.063 | 1 | 0.770 |
IKKB |
0.852 | 0.055 | -2 | 0.716 |
AURC |
0.852 | 0.251 | -2 | 0.673 |
HIPK2 |
0.851 | 0.294 | 1 | 0.642 |
WNK1 |
0.850 | 0.183 | -2 | 0.857 |
CLK4 |
0.850 | 0.325 | -3 | 0.890 |
MSK1 |
0.850 | 0.309 | -3 | 0.869 |
CAMK2A |
0.849 | 0.275 | 2 | 0.827 |
MOS |
0.849 | 0.092 | 1 | 0.805 |
NDR1 |
0.849 | 0.186 | -3 | 0.892 |
PRPK |
0.849 | -0.001 | -1 | 0.840 |
NLK |
0.849 | 0.121 | 1 | 0.836 |
LATS2 |
0.849 | 0.174 | -5 | 0.716 |
PKACG |
0.849 | 0.223 | -2 | 0.723 |
CAMK2B |
0.849 | 0.256 | 2 | 0.817 |
CLK1 |
0.849 | 0.337 | -3 | 0.868 |
TBK1 |
0.849 | 0.071 | 1 | 0.774 |
MSK2 |
0.848 | 0.278 | -3 | 0.876 |
RAF1 |
0.848 | 0.096 | 1 | 0.842 |
PKACB |
0.848 | 0.297 | -2 | 0.682 |
SRPK3 |
0.847 | 0.282 | -3 | 0.878 |
CAMLCK |
0.847 | 0.243 | -2 | 0.840 |
PKN3 |
0.847 | 0.203 | -3 | 0.901 |
PDHK4 |
0.847 | -0.042 | 1 | 0.855 |
RSK4 |
0.846 | 0.298 | -3 | 0.863 |
DAPK2 |
0.846 | 0.262 | -3 | 0.920 |
NUAK2 |
0.846 | 0.191 | -3 | 0.912 |
ATR |
0.846 | 0.055 | 1 | 0.790 |
CAMK2G |
0.845 | 0.029 | 2 | 0.832 |
HIPK1 |
0.845 | 0.296 | 1 | 0.742 |
PRKD3 |
0.845 | 0.284 | -3 | 0.867 |
PAK1 |
0.845 | 0.215 | -2 | 0.805 |
IKKE |
0.844 | 0.045 | 1 | 0.771 |
MARK4 |
0.844 | 0.124 | 4 | 0.750 |
MST4 |
0.844 | 0.130 | 2 | 0.799 |
ERK5 |
0.844 | 0.073 | 1 | 0.801 |
RIPK3 |
0.844 | 0.085 | 3 | 0.758 |
NIK |
0.844 | 0.195 | -3 | 0.908 |
P70S6KB |
0.843 | 0.219 | -3 | 0.897 |
PKCD |
0.843 | 0.208 | 2 | 0.747 |
DYRK1A |
0.843 | 0.298 | 1 | 0.748 |
PKN2 |
0.843 | 0.180 | -3 | 0.899 |
CHAK2 |
0.842 | 0.087 | -1 | 0.845 |
KIS |
0.842 | 0.101 | 1 | 0.702 |
GRK1 |
0.842 | 0.105 | -2 | 0.723 |
PAK3 |
0.842 | 0.187 | -2 | 0.801 |
DSTYK |
0.842 | -0.007 | 2 | 0.863 |
PRKX |
0.841 | 0.289 | -3 | 0.798 |
AMPKA1 |
0.841 | 0.157 | -3 | 0.899 |
PAK6 |
0.841 | 0.208 | -2 | 0.735 |
DYRK4 |
0.840 | 0.240 | 1 | 0.651 |
ULK2 |
0.840 | -0.056 | 2 | 0.754 |
MNK2 |
0.840 | 0.189 | -2 | 0.798 |
PDHK1 |
0.840 | -0.058 | 1 | 0.853 |
GCN2 |
0.840 | -0.139 | 2 | 0.779 |
AKT2 |
0.840 | 0.308 | -3 | 0.842 |
CDK8 |
0.840 | 0.105 | 1 | 0.693 |
BMPR2 |
0.839 | -0.104 | -2 | 0.824 |
SGK3 |
0.839 | 0.290 | -3 | 0.861 |
CDK19 |
0.839 | 0.125 | 1 | 0.657 |
AMPKA2 |
0.838 | 0.179 | -3 | 0.885 |
TSSK1 |
0.838 | 0.172 | -3 | 0.902 |
AURB |
0.838 | 0.200 | -2 | 0.672 |
NIM1 |
0.837 | 0.118 | 3 | 0.764 |
IKKA |
0.837 | 0.016 | -2 | 0.712 |
HIPK3 |
0.837 | 0.271 | 1 | 0.740 |
MYLK4 |
0.837 | 0.227 | -2 | 0.782 |
LATS1 |
0.837 | 0.222 | -3 | 0.874 |
DYRK3 |
0.837 | 0.289 | 1 | 0.745 |
CDK7 |
0.836 | 0.110 | 1 | 0.686 |
PKG2 |
0.836 | 0.210 | -2 | 0.667 |
PKCA |
0.836 | 0.181 | 2 | 0.686 |
TSSK2 |
0.836 | 0.127 | -5 | 0.834 |
CDK18 |
0.835 | 0.150 | 1 | 0.624 |
BCKDK |
0.835 | -0.034 | -1 | 0.757 |
GRK5 |
0.835 | -0.076 | -3 | 0.852 |
JNK2 |
0.835 | 0.159 | 1 | 0.646 |
QSK |
0.835 | 0.171 | 4 | 0.720 |
PKCG |
0.835 | 0.158 | 2 | 0.701 |
MAPKAPK5 |
0.835 | 0.215 | -3 | 0.858 |
NEK6 |
0.834 | -0.050 | -2 | 0.798 |
MASTL |
0.834 | -0.057 | -2 | 0.782 |
PKACA |
0.834 | 0.273 | -2 | 0.635 |
PKCB |
0.833 | 0.162 | 2 | 0.691 |
HUNK |
0.833 | -0.042 | 2 | 0.773 |
DYRK1B |
0.833 | 0.221 | 1 | 0.666 |
RIPK1 |
0.833 | 0.021 | 1 | 0.800 |
SIK |
0.833 | 0.196 | -3 | 0.866 |
TGFBR2 |
0.833 | -0.038 | -2 | 0.714 |
MAK |
0.833 | 0.372 | -2 | 0.814 |
GRK6 |
0.832 | 0.006 | 1 | 0.809 |
FAM20C |
0.832 | 0.144 | 2 | 0.705 |
PAK2 |
0.832 | 0.149 | -2 | 0.785 |
NEK7 |
0.832 | -0.120 | -3 | 0.844 |
MLK2 |
0.832 | 0.026 | 2 | 0.780 |
NUAK1 |
0.832 | 0.152 | -3 | 0.877 |
PHKG1 |
0.832 | 0.142 | -3 | 0.892 |
MELK |
0.832 | 0.164 | -3 | 0.878 |
CAMK4 |
0.832 | 0.101 | -3 | 0.885 |
PIM2 |
0.832 | 0.247 | -3 | 0.873 |
MLK1 |
0.832 | -0.074 | 2 | 0.768 |
DLK |
0.831 | 0.008 | 1 | 0.835 |
MNK1 |
0.831 | 0.162 | -2 | 0.793 |
DCAMKL1 |
0.831 | 0.238 | -3 | 0.867 |
NEK9 |
0.830 | -0.042 | 2 | 0.789 |
WNK3 |
0.830 | -0.084 | 1 | 0.813 |
BRSK1 |
0.830 | 0.148 | -3 | 0.880 |
ULK1 |
0.829 | -0.115 | -3 | 0.807 |
AURA |
0.829 | 0.171 | -2 | 0.660 |
PKCZ |
0.829 | 0.125 | 2 | 0.739 |
P38B |
0.829 | 0.142 | 1 | 0.658 |
QIK |
0.828 | 0.078 | -3 | 0.890 |
AKT1 |
0.828 | 0.285 | -3 | 0.842 |
P38A |
0.828 | 0.133 | 1 | 0.721 |
CDK13 |
0.828 | 0.073 | 1 | 0.664 |
JNK3 |
0.828 | 0.115 | 1 | 0.674 |
DNAPK |
0.828 | 0.091 | 1 | 0.702 |
CAMK1G |
0.827 | 0.193 | -3 | 0.890 |
ATM |
0.827 | -0.012 | 1 | 0.719 |
GRK7 |
0.825 | 0.068 | 1 | 0.760 |
BRSK2 |
0.825 | 0.082 | -3 | 0.879 |
MARK3 |
0.825 | 0.101 | 4 | 0.672 |
PKCH |
0.825 | 0.118 | 2 | 0.682 |
ANKRD3 |
0.825 | -0.070 | 1 | 0.840 |
ERK1 |
0.825 | 0.106 | 1 | 0.652 |
IRE1 |
0.825 | -0.027 | 1 | 0.770 |
CDK1 |
0.824 | 0.085 | 1 | 0.651 |
CDK12 |
0.824 | 0.091 | 1 | 0.642 |
CDK14 |
0.824 | 0.149 | 1 | 0.669 |
TTBK2 |
0.824 | -0.097 | 2 | 0.683 |
CDK5 |
0.824 | 0.096 | 1 | 0.698 |
NEK2 |
0.823 | 0.030 | 2 | 0.772 |
PKR |
0.823 | 0.045 | 1 | 0.813 |
CDK17 |
0.823 | 0.099 | 1 | 0.577 |
BMPR1B |
0.823 | 0.041 | 1 | 0.747 |
AKT3 |
0.823 | 0.313 | -3 | 0.795 |
PAK4 |
0.823 | 0.190 | -2 | 0.700 |
YSK4 |
0.823 | 0.005 | 1 | 0.802 |
PAK5 |
0.823 | 0.179 | -2 | 0.683 |
TGFBR1 |
0.823 | -0.001 | -2 | 0.725 |
MLK3 |
0.822 | -0.025 | 2 | 0.705 |
GRK4 |
0.822 | -0.124 | -2 | 0.756 |
MARK2 |
0.822 | 0.070 | 4 | 0.652 |
P38G |
0.822 | 0.102 | 1 | 0.576 |
ALK4 |
0.822 | -0.040 | -2 | 0.750 |
CDK9 |
0.822 | 0.067 | 1 | 0.674 |
CDK10 |
0.822 | 0.159 | 1 | 0.650 |
CAMK1D |
0.822 | 0.244 | -3 | 0.817 |
PASK |
0.821 | 0.195 | -3 | 0.911 |
SMMLCK |
0.821 | 0.210 | -3 | 0.911 |
PLK1 |
0.821 | -0.051 | -2 | 0.740 |
CHK1 |
0.821 | 0.101 | -3 | 0.838 |
SMG1 |
0.821 | -0.043 | 1 | 0.745 |
MEK1 |
0.820 | -0.068 | 2 | 0.807 |
P70S6K |
0.820 | 0.192 | -3 | 0.847 |
SGK1 |
0.820 | 0.304 | -3 | 0.780 |
VRK2 |
0.820 | -0.058 | 1 | 0.857 |
MOK |
0.820 | 0.315 | 1 | 0.744 |
PKCT |
0.820 | 0.158 | 2 | 0.686 |
TLK2 |
0.819 | -0.027 | 1 | 0.787 |
DCAMKL2 |
0.818 | 0.146 | -3 | 0.882 |
SNRK |
0.818 | 0.008 | 2 | 0.662 |
MPSK1 |
0.818 | 0.141 | 1 | 0.773 |
MARK1 |
0.817 | 0.066 | 4 | 0.691 |
CHAK1 |
0.817 | -0.056 | 2 | 0.756 |
WNK4 |
0.817 | 0.060 | -2 | 0.840 |
DAPK3 |
0.816 | 0.238 | -3 | 0.897 |
P38D |
0.816 | 0.114 | 1 | 0.578 |
CK1E |
0.816 | 0.047 | -3 | 0.597 |
MST3 |
0.816 | 0.094 | 2 | 0.789 |
PLK4 |
0.815 | -0.014 | 2 | 0.607 |
ERK2 |
0.815 | 0.041 | 1 | 0.695 |
PRP4 |
0.815 | 0.052 | -3 | 0.743 |
PKCE |
0.814 | 0.177 | 2 | 0.686 |
SSTK |
0.814 | 0.088 | 4 | 0.721 |
PKCI |
0.814 | 0.126 | 2 | 0.702 |
PLK3 |
0.814 | -0.074 | 2 | 0.779 |
GSK3A |
0.814 | 0.083 | 4 | 0.470 |
GSK3B |
0.814 | 0.055 | 4 | 0.464 |
MLK4 |
0.814 | -0.065 | 2 | 0.680 |
PHKG2 |
0.814 | 0.101 | -3 | 0.874 |
SBK |
0.814 | 0.295 | -3 | 0.753 |
IRE2 |
0.813 | -0.059 | 2 | 0.712 |
CDK3 |
0.813 | 0.083 | 1 | 0.591 |
DAPK1 |
0.813 | 0.234 | -3 | 0.896 |
CDK16 |
0.812 | 0.097 | 1 | 0.593 |
NEK5 |
0.812 | 0.014 | 1 | 0.811 |
CAMK1A |
0.812 | 0.250 | -3 | 0.807 |
MRCKB |
0.812 | 0.255 | -3 | 0.856 |
ALK2 |
0.812 | -0.048 | -2 | 0.723 |
DRAK1 |
0.812 | -0.008 | 1 | 0.745 |
CHK2 |
0.812 | 0.256 | -3 | 0.798 |
ACVR2A |
0.812 | -0.060 | -2 | 0.709 |
TAO3 |
0.812 | 0.063 | 1 | 0.812 |
ACVR2B |
0.812 | -0.056 | -2 | 0.719 |
ROCK2 |
0.811 | 0.266 | -3 | 0.870 |
CK1G1 |
0.811 | 0.043 | -3 | 0.588 |
PKN1 |
0.810 | 0.199 | -3 | 0.856 |
BRAF |
0.810 | -0.021 | -4 | 0.854 |
MEK5 |
0.810 | -0.112 | 2 | 0.787 |
GRK2 |
0.810 | -0.058 | -2 | 0.660 |
PDK1 |
0.809 | 0.136 | 1 | 0.791 |
MRCKA |
0.809 | 0.225 | -3 | 0.860 |
CDK2 |
0.809 | -0.016 | 1 | 0.730 |
IRAK4 |
0.808 | -0.019 | 1 | 0.780 |
MEKK3 |
0.807 | -0.105 | 1 | 0.819 |
LKB1 |
0.807 | 0.060 | -3 | 0.827 |
MEKK1 |
0.807 | -0.090 | 1 | 0.811 |
MEKK2 |
0.807 | -0.051 | 2 | 0.766 |
ZAK |
0.807 | -0.087 | 1 | 0.803 |
NEK11 |
0.806 | -0.002 | 1 | 0.804 |
CK1D |
0.806 | 0.035 | -3 | 0.552 |
GCK |
0.806 | 0.132 | 1 | 0.823 |
PINK1 |
0.805 | -0.136 | 1 | 0.805 |
CK1A2 |
0.805 | 0.045 | -3 | 0.559 |
PERK |
0.805 | -0.157 | -2 | 0.751 |
JNK1 |
0.804 | 0.069 | 1 | 0.629 |
HPK1 |
0.804 | 0.153 | 1 | 0.815 |
GAK |
0.804 | 0.035 | 1 | 0.808 |
MAP3K15 |
0.803 | 0.091 | 1 | 0.792 |
MEKK6 |
0.803 | 0.079 | 1 | 0.804 |
ERK7 |
0.803 | 0.039 | 2 | 0.521 |
TLK1 |
0.803 | -0.115 | -2 | 0.768 |
DMPK1 |
0.803 | 0.262 | -3 | 0.873 |
NEK4 |
0.802 | 0.031 | 1 | 0.802 |
KHS1 |
0.802 | 0.196 | 1 | 0.814 |
HGK |
0.802 | 0.084 | 3 | 0.840 |
TNIK |
0.802 | 0.122 | 3 | 0.837 |
CAMKK2 |
0.802 | -0.030 | -2 | 0.723 |
HRI |
0.801 | -0.205 | -2 | 0.785 |
TAO2 |
0.800 | -0.022 | 2 | 0.808 |
BMPR1A |
0.800 | -0.036 | 1 | 0.721 |
CAMKK1 |
0.800 | -0.099 | -2 | 0.717 |
CDK4 |
0.800 | 0.088 | 1 | 0.632 |
TTBK1 |
0.800 | -0.128 | 2 | 0.615 |
MINK |
0.800 | 0.089 | 1 | 0.820 |
NEK8 |
0.799 | -0.083 | 2 | 0.780 |
KHS2 |
0.799 | 0.175 | 1 | 0.825 |
CRIK |
0.798 | 0.248 | -3 | 0.841 |
LOK |
0.798 | 0.061 | -2 | 0.738 |
PKG1 |
0.798 | 0.176 | -2 | 0.576 |
ROCK1 |
0.797 | 0.237 | -3 | 0.859 |
CDK6 |
0.797 | 0.062 | 1 | 0.647 |
LRRK2 |
0.796 | -0.006 | 2 | 0.815 |
BUB1 |
0.796 | 0.120 | -5 | 0.773 |
GRK3 |
0.796 | -0.056 | -2 | 0.611 |
IRAK1 |
0.795 | -0.169 | -1 | 0.741 |
NEK1 |
0.795 | 0.021 | 1 | 0.795 |
STK33 |
0.795 | -0.049 | 2 | 0.614 |
PBK |
0.794 | 0.068 | 1 | 0.726 |
TAK1 |
0.794 | 0.003 | 1 | 0.826 |
MST2 |
0.793 | -0.053 | 1 | 0.819 |
SLK |
0.792 | 0.005 | -2 | 0.681 |
EEF2K |
0.792 | -0.030 | 3 | 0.800 |
CK2A2 |
0.791 | 0.002 | 1 | 0.638 |
HASPIN |
0.789 | 0.108 | -1 | 0.772 |
PLK2 |
0.789 | -0.059 | -3 | 0.740 |
VRK1 |
0.788 | -0.093 | 2 | 0.789 |
YSK1 |
0.788 | 0.013 | 2 | 0.760 |
PDHK3_TYR |
0.788 | 0.225 | 4 | 0.835 |
MST1 |
0.788 | -0.045 | 1 | 0.812 |
RIPK2 |
0.784 | -0.149 | 1 | 0.762 |
CK2A1 |
0.783 | -0.004 | 1 | 0.620 |
NEK3 |
0.782 | -0.037 | 1 | 0.774 |
MEK2 |
0.782 | -0.171 | 2 | 0.767 |
YANK3 |
0.780 | -0.008 | 2 | 0.419 |
MAP2K4_TYR |
0.779 | 0.116 | -1 | 0.843 |
ASK1 |
0.779 | 0.006 | 1 | 0.780 |
PDHK4_TYR |
0.778 | 0.061 | 2 | 0.868 |
TESK1_TYR |
0.778 | 0.052 | 3 | 0.862 |
LIMK2_TYR |
0.778 | 0.143 | -3 | 0.882 |
MAP2K6_TYR |
0.777 | 0.057 | -1 | 0.837 |
MYO3B |
0.777 | 0.021 | 2 | 0.783 |
PKMYT1_TYR |
0.777 | 0.060 | 3 | 0.839 |
MAP2K7_TYR |
0.775 | -0.027 | 2 | 0.843 |
OSR1 |
0.774 | -0.066 | 2 | 0.752 |
BMPR2_TYR |
0.773 | 0.046 | -1 | 0.836 |
BIKE |
0.773 | 0.002 | 1 | 0.688 |
PDHK1_TYR |
0.772 | 0.008 | -1 | 0.833 |
CK1A |
0.771 | 0.009 | -3 | 0.466 |
TAO1 |
0.770 | -0.040 | 1 | 0.757 |
TTK |
0.770 | -0.082 | -2 | 0.753 |
PINK1_TYR |
0.769 | -0.083 | 1 | 0.828 |
MYO3A |
0.769 | -0.032 | 1 | 0.791 |
RET |
0.768 | 0.008 | 1 | 0.815 |
EPHA6 |
0.768 | 0.072 | -1 | 0.790 |
TNK2 |
0.766 | 0.090 | 3 | 0.738 |
LIMK1_TYR |
0.765 | -0.084 | 2 | 0.826 |
EPHB4 |
0.764 | 0.027 | -1 | 0.766 |
MST1R |
0.764 | -0.036 | 3 | 0.798 |
DDR1 |
0.763 | -0.040 | 4 | 0.761 |
ABL2 |
0.762 | 0.024 | -1 | 0.757 |
AAK1 |
0.761 | 0.047 | 1 | 0.589 |
ALPHAK3 |
0.761 | -0.099 | -1 | 0.740 |
JAK2 |
0.761 | -0.048 | 1 | 0.810 |
CSF1R |
0.761 | -0.028 | 3 | 0.787 |
ROS1 |
0.761 | -0.039 | 3 | 0.751 |
TYK2 |
0.760 | -0.113 | 1 | 0.809 |
TNK1 |
0.760 | 0.054 | 3 | 0.768 |
TYRO3 |
0.760 | -0.092 | 3 | 0.777 |
TXK |
0.759 | 0.048 | 1 | 0.784 |
NEK10_TYR |
0.758 | 0.015 | 1 | 0.719 |
ABL1 |
0.758 | -0.002 | -1 | 0.751 |
JAK3 |
0.757 | -0.059 | 1 | 0.795 |
FGR |
0.757 | -0.079 | 1 | 0.824 |
STLK3 |
0.756 | -0.147 | 1 | 0.776 |
YES1 |
0.756 | -0.071 | -1 | 0.798 |
JAK1 |
0.755 | 0.023 | 1 | 0.774 |
TNNI3K_TYR |
0.755 | 0.028 | 1 | 0.818 |
EPHA4 |
0.754 | -0.030 | 2 | 0.783 |
KDR |
0.753 | -0.038 | 3 | 0.757 |
SRMS |
0.753 | -0.057 | 1 | 0.805 |
INSRR |
0.752 | -0.084 | 3 | 0.725 |
FGFR2 |
0.752 | -0.096 | 3 | 0.781 |
KIT |
0.752 | -0.079 | 3 | 0.787 |
MERTK |
0.752 | -0.036 | 3 | 0.768 |
ITK |
0.751 | -0.044 | -1 | 0.753 |
AXL |
0.751 | -0.056 | 3 | 0.767 |
LCK |
0.751 | -0.022 | -1 | 0.777 |
HCK |
0.751 | -0.083 | -1 | 0.773 |
FER |
0.751 | -0.157 | 1 | 0.817 |
EPHB3 |
0.750 | -0.045 | -1 | 0.740 |
BMX |
0.749 | -0.019 | -1 | 0.697 |
PDGFRB |
0.749 | -0.131 | 3 | 0.787 |
EPHB1 |
0.749 | -0.085 | 1 | 0.807 |
DDR2 |
0.748 | 0.044 | 3 | 0.711 |
MET |
0.748 | -0.065 | 3 | 0.772 |
BLK |
0.748 | -0.016 | -1 | 0.774 |
EPHB2 |
0.748 | -0.059 | -1 | 0.736 |
FGFR1 |
0.747 | -0.120 | 3 | 0.748 |
CK1G3 |
0.747 | -0.010 | -3 | 0.423 |
FLT3 |
0.746 | -0.146 | 3 | 0.780 |
FYN |
0.746 | -0.010 | -1 | 0.766 |
TEK |
0.746 | -0.129 | 3 | 0.711 |
EPHA1 |
0.744 | -0.033 | 3 | 0.755 |
EPHA7 |
0.744 | -0.032 | 2 | 0.777 |
YANK2 |
0.743 | -0.055 | 2 | 0.439 |
EPHA3 |
0.743 | -0.086 | 2 | 0.753 |
PDGFRA |
0.743 | -0.167 | 3 | 0.781 |
FLT1 |
0.743 | -0.091 | -1 | 0.751 |
WEE1_TYR |
0.742 | -0.108 | -1 | 0.741 |
TEC |
0.742 | -0.108 | -1 | 0.701 |
LTK |
0.741 | -0.110 | 3 | 0.723 |
NTRK1 |
0.741 | -0.154 | -1 | 0.757 |
PTK2B |
0.741 | -0.039 | -1 | 0.734 |
FGFR3 |
0.741 | -0.121 | 3 | 0.753 |
ERBB2 |
0.740 | -0.134 | 1 | 0.778 |
BTK |
0.740 | -0.194 | -1 | 0.722 |
ALK |
0.739 | -0.145 | 3 | 0.689 |
PTK6 |
0.739 | -0.200 | -1 | 0.693 |
NTRK3 |
0.738 | -0.096 | -1 | 0.709 |
FLT4 |
0.737 | -0.150 | 3 | 0.750 |
INSR |
0.736 | -0.150 | 3 | 0.705 |
EPHA5 |
0.736 | -0.069 | 2 | 0.770 |
NTRK2 |
0.736 | -0.190 | 3 | 0.738 |
LYN |
0.736 | -0.110 | 3 | 0.714 |
FRK |
0.735 | -0.121 | -1 | 0.762 |
SRC |
0.735 | -0.082 | -1 | 0.757 |
PTK2 |
0.734 | 0.010 | -1 | 0.734 |
CSK |
0.734 | -0.101 | 2 | 0.777 |
EPHA8 |
0.733 | -0.071 | -1 | 0.728 |
EGFR |
0.733 | -0.081 | 1 | 0.694 |
FGFR4 |
0.732 | -0.077 | -1 | 0.705 |
MATK |
0.731 | -0.128 | -1 | 0.693 |
SYK |
0.726 | -0.045 | -1 | 0.704 |
EPHA2 |
0.724 | -0.067 | -1 | 0.695 |
ERBB4 |
0.723 | -0.051 | 1 | 0.691 |
CK1G2 |
0.722 | -0.054 | -3 | 0.512 |
IGF1R |
0.721 | -0.150 | 3 | 0.644 |
MUSK |
0.716 | -0.168 | 1 | 0.679 |
ZAP70 |
0.714 | -0.017 | -1 | 0.669 |
FES |
0.708 | -0.161 | -1 | 0.675 |