Motif 201 (n=499)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A096LP49	CCDC187	S777	ochoa	Coiled-coil domain-containing protein 187	None
A0A0C4DFX4	None	S1767	ochoa	Snf2 related CREBBP activator protein	None
A0A1W2PPC1	PRR33	S207	ochoa	Proline rich 33	None
A4UGR9	XIRP2	S2348	ochoa	Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)	Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250\|UniProtKB:Q4U4S6, ECO:0000269\|PubMed:15454575}.
A6NFI3	ZNF316	S328	ochoa	Zinc finger protein 316	May be involved in transcriptional regulation. {ECO:0000250}.
A6NFX1	MFSD2B	S26	ochoa	Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b)	Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). {ECO:0000250\|UniProtKB:Q3T9M1, ECO:0000269\|PubMed:29045386, ECO:0000305\|PubMed:29563527}.
A6NGB9	WIPF3	S149	ochoa	WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)	May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity). {ECO:0000250}.
A6NJZ7	RIMBP3C	S1228	ochoa	RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3)	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250\|UniProtKB:Q3V0F0}.
A6NNM3	RIMBP3B	S1228	ochoa	RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2)	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250\|UniProtKB:Q3V0F0}.
A7MCY6	TBKBP1	S365	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
A8MZF0	PRR33	S59	ochoa	Proline-rich protein 33	None
E9PAV3	NACA	S1411	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
H0Y626	None	S38	ochoa	RING-type E3 ubiquitin transferase (EC 2.3.2.27)	None
O00186	STXBP3	S464	ochoa	Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)	Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.
O00213	APBB1	S205	ochoa	Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)	Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347). {ECO:0000250\|UniProtKB:Q9QXJ1, ECO:0000269\|PubMed:15031292, ECO:0000269\|PubMed:18468999, ECO:0000269\|PubMed:18922798, ECO:0000269\|PubMed:19234442, ECO:0000269\|PubMed:19343227, ECO:0000269\|PubMed:25342469, ECO:0000269\|PubMed:33938178, ECO:0000269\|PubMed:36250347}.
O00267	SUPT5H	S782	ochoa\|psp	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269\|PubMed:10075709, ECO:0000269\|PubMed:10199401, ECO:0000269\|PubMed:10393184, ECO:0000269\|PubMed:10421630, ECO:0000269\|PubMed:10454543, ECO:0000269\|PubMed:10757782, ECO:0000269\|PubMed:10912001, ECO:0000269\|PubMed:11112772, ECO:0000269\|PubMed:11553615, ECO:0000269\|PubMed:11809800, ECO:0000269\|PubMed:12653964, ECO:0000269\|PubMed:12718890, ECO:0000269\|PubMed:14701750, ECO:0000269\|PubMed:15136722, ECO:0000269\|PubMed:15380072, ECO:0000269\|PubMed:16214896, ECO:0000269\|PubMed:16427012, ECO:0000269\|PubMed:9450929, ECO:0000269\|PubMed:9514752, ECO:0000269\|PubMed:9857195}.
O00330	PDHX	S162	ochoa	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
O00499	BIN1	S303	ochoa	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)	Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250\|UniProtKB:O08839, ECO:0000269\|PubMed:24755653, ECO:0000269\|PubMed:27179792, ECO:0000269\|PubMed:28893863, ECO:0000269\|PubMed:8782822}.
O14497	ARID1A	S1320	ochoa	AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250\|UniProtKB:A2BH40, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
O14545	TRAFD1	S487	ochoa	TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)	Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16221674}.
O14686	KMT2D	S2654	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14686	KMT2D	S4359	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14686	KMT2D	S4974	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14920	IKBKB	S697	ochoa	Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250\|UniProtKB:O88351, ECO:0000269\|PubMed:11297557, ECO:0000269\|PubMed:14673179, ECO:0000269\|PubMed:15084260, ECO:0000269\|PubMed:17213322, ECO:0000269\|PubMed:19716809, ECO:0000269\|PubMed:20410276, ECO:0000269\|PubMed:20434986, ECO:0000269\|PubMed:20797629, ECO:0000269\|PubMed:21138416, ECO:0000269\|PubMed:25326418, ECO:0000269\|PubMed:30337470, ECO:0000269\|PubMed:32209697, ECO:0000269\|PubMed:38621137, ECO:0000269\|PubMed:9346484}.
O15164	TRIM24	S98	ochoa	Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269\|PubMed:16322096, ECO:0000269\|PubMed:19556538, ECO:0000269\|PubMed:21164480, ECO:0000269\|PubMed:24820418, ECO:0000269\|PubMed:32324863, ECO:0000269\|PubMed:33724611}.
O15297	PPM1D	S54	psp	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). {ECO:0000250\|UniProtKB:Q9QZ67, ECO:0000269\|PubMed:15870257, ECO:0000269\|PubMed:16311512, ECO:0000269\|PubMed:21283629, ECO:0000269\|PubMed:23242139}.
O15446	POLR1G	S490	ochoa	DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49)	Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269\|PubMed:34671025, ECO:0000269\|PubMed:34887565, ECO:0000269\|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269\|PubMed:10373416}.
O43294	TGFB1I1	S37	ochoa	Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)	Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269\|PubMed:10075738, ECO:0000269\|PubMed:11463817, ECO:0000269\|PubMed:11856738, ECO:0000269\|PubMed:12177201, ECO:0000269\|PubMed:12445807, ECO:0000269\|PubMed:12700349, ECO:0000269\|PubMed:15211577, ECO:0000269\|PubMed:15561701, ECO:0000269\|PubMed:16141357, ECO:0000269\|PubMed:16624805, ECO:0000269\|PubMed:16803896, ECO:0000269\|PubMed:16849583, ECO:0000269\|PubMed:17166536, ECO:0000269\|PubMed:17233630, ECO:0000269\|PubMed:9032249}.
O43464	HTRA2	S142	psp	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	[Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269\|PubMed:10873535, ECO:0000269\|PubMed:15200957, ECO:0000269\|PubMed:19502560, ECO:0000269\|PubMed:36758104, ECO:0000269\|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269\|PubMed:10995577}.
O60269	GPRIN2	S26	ochoa	G protein-regulated inducer of neurite outgrowth 2 (GRIN2)	May be involved in neurite outgrowth. {ECO:0000269\|PubMed:10480904}.
O60307	MAST3	S935	ochoa	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	None
O60337	MARCHF6	S31	ochoa	E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176) (RING-type E3 ubiquitin transferase MARCHF6)	Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis (PubMed:25088257, PubMed:35941365, PubMed:39216628). Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates) (PubMed:30425097, PubMed:35941365). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G-protein regulator RGS2 and the lipid droplet protein PLIN2 (PubMed:39216628). Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region (PubMed:35941365). Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins (PubMed:29519897). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). By ubiquitinating and thereby modulating the stability of many proteins of the cholesterol pathway including SQLE, CYP51A1, CYP11A1 and HMGCR, acts as a crucial post-translational regulator of cholesterol synthesis (PubMed:24449766, PubMed:31904814, PubMed:36958722). {ECO:0000250\|UniProtKB:Q6ZQ89, ECO:0000269\|PubMed:15673284, ECO:0000269\|PubMed:19651899, ECO:0000269\|PubMed:24449766, ECO:0000269\|PubMed:25088257, ECO:0000269\|PubMed:29519897, ECO:0000269\|PubMed:30425097, ECO:0000269\|PubMed:31904814, ECO:0000269\|PubMed:35941365, ECO:0000269\|PubMed:36958722, ECO:0000269\|PubMed:39216628}.
O60346	PHLPP1	S1359	psp	PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250\|UniProtKB:Q8CHE4, ECO:0000250\|UniProtKB:Q9WTR8, ECO:0000269\|PubMed:15808505, ECO:0000269\|PubMed:17386267, ECO:0000269\|PubMed:18162466, ECO:0000269\|PubMed:19079341, ECO:0000269\|PubMed:21986499, ECO:0000269\|PubMed:24530606}.
O60732	MAGEC1	S207	ochoa	Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen)	None
O60885	BRD4	S488	psp	Bromodomain-containing protein 4 (Protein HUNK1)	Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250\|UniProtKB:Q9ESU6, ECO:0000269\|PubMed:16109376, ECO:0000269\|PubMed:16109377, ECO:0000269\|PubMed:19103749, ECO:0000269\|PubMed:19596240, ECO:0000269\|PubMed:22334664, ECO:0000269\|PubMed:22509028, ECO:0000269\|PubMed:23086925, ECO:0000269\|PubMed:23317504, ECO:0000269\|PubMed:23589332, ECO:0000269\|PubMed:24360279, ECO:0000269\|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269\|PubMed:23728299}.
O75128	COBL	S317	ochoa	Protein cordon-bleu	Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269\|PubMed:21816349}.
O75145	PPFIA3	S683	ochoa	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3)	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269\|PubMed:9624153}.
O75175	CNOT3	S507	ochoa	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269\|PubMed:14707134, ECO:0000269\|PubMed:22342980, ECO:0000269\|PubMed:22367759}.
O75330	HMMR	S20	ochoa	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)	Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). {ECO:0000250\|UniProtKB:Q00547}.
O75376	NCOR1	S2098	ochoa	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250\|UniProtKB:Q60974, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:20812024}.
O75808	CAPN15	S233	ochoa	Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)	None
O76080	ZFAND5	S135	ochoa	AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)	Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269\|PubMed:14754897}.
O94761	RECQL4	S323	ochoa	ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)	An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269\|PubMed:15317757, ECO:0000269\|PubMed:22730300, ECO:0000269\|PubMed:28653661}.
O94880	PHF14	S574	ochoa	PHD finger protein 14	Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250\|UniProtKB:A0A286Y9D1, ECO:0000250\|UniProtKB:Q9D4H9, ECO:0000269\|PubMed:23688586}.
O94887	FARP2	S476	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)	Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O95251	KAT7	S99	ochoa	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250\|UniProtKB:Q5SVQ0, ECO:0000269\|PubMed:10438470, ECO:0000269\|PubMed:11278932, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:16997280, ECO:0000269\|PubMed:18832067, ECO:0000269\|PubMed:19187766, ECO:0000269\|PubMed:20129055, ECO:0000269\|PubMed:21753189, ECO:0000269\|PubMed:21856198, ECO:0000269\|PubMed:24065767, ECO:0000269\|PubMed:26620551, ECO:0000269\|PubMed:27270040, ECO:0000269\|PubMed:28719581, ECO:0000269\|PubMed:31767635, ECO:0000269\|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269\|PubMed:31827282}.
O95359	TACC2	S2321	ochoa	Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269\|PubMed:10749935}.
O95359	TACC2	S2576	ochoa	Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269\|PubMed:10749935}.
O95361	TRIM16	S38	ochoa	Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)	E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269\|PubMed:22629402, ECO:0000269\|PubMed:27693506, ECO:0000269\|PubMed:30143514}.
O95382	MAP3K6	S964	ochoa\|psp	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)	Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269\|PubMed:17210579, ECO:0000269\|PubMed:9875215}.
O95644	NFATC1	S772	ochoa	Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250\|UniProtKB:O88942, ECO:0000269\|PubMed:10358178}.
P04792	HSPB1	S65	ochoa	Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269\|PubMed:10383393, ECO:0000269\|PubMed:19166925, ECO:0000269\|PubMed:20178975, ECO:0000269\|PubMed:23728742}.
P09874	PARP1	S383	ochoa	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250\|UniProtKB:P11103, ECO:0000269\|PubMed:15607977, ECO:0000269\|PubMed:17177976, ECO:0000269\|PubMed:17396150, ECO:0000269\|PubMed:18055453, ECO:0000269\|PubMed:18172500, ECO:0000269\|PubMed:19344625, ECO:0000269\|PubMed:19661379, ECO:0000269\|PubMed:19764761, ECO:0000269\|PubMed:20388712, ECO:0000269\|PubMed:21680843, ECO:0000269\|PubMed:22464733, ECO:0000269\|PubMed:22582261, ECO:0000269\|PubMed:23230272, ECO:0000269\|PubMed:24906880, ECO:0000269\|PubMed:25043379, ECO:0000269\|PubMed:26344098, ECO:0000269\|PubMed:26626479, ECO:0000269\|PubMed:26626480, ECO:0000269\|PubMed:27067600, ECO:0000269\|PubMed:27256882, ECO:0000269\|PubMed:27257257, ECO:0000269\|PubMed:27471034, ECO:0000269\|PubMed:28190768, ECO:0000269\|PubMed:29954836, ECO:0000269\|PubMed:30104678, ECO:0000269\|PubMed:30257210, ECO:0000269\|PubMed:30356214, ECO:0000269\|PubMed:31796734, ECO:0000269\|PubMed:32028527, ECO:0000269\|PubMed:32241924, ECO:0000269\|PubMed:32315358, ECO:0000269\|PubMed:32358582, ECO:0000269\|PubMed:32844745, ECO:0000269\|PubMed:33186521, ECO:0000269\|PubMed:33412112, ECO:0000269\|PubMed:33589610, ECO:0000269\|PubMed:33683197, ECO:0000269\|PubMed:34049076, ECO:0000269\|PubMed:34465625, ECO:0000269\|PubMed:34625544, ECO:0000269\|PubMed:34732825, ECO:0000269\|PubMed:34737271, ECO:0000269\|PubMed:34795260, ECO:0000269\|PubMed:34874266, ECO:0000269\|PubMed:35124853, ECO:0000269\|PubMed:35393539, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:7852410, ECO:0000269\|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269\|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269\|PubMed:35104452}.
P10636	MAPT	S341	ochoa	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
P10636	MAPT	S428	ochoa	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
P10645	CHGA	S203	ochoa\|psp	Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]	[Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas.; FUNCTION: [Catestatin]: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172, PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). {ECO:0000269\|PubMed:15326220, ECO:0000269\|PubMed:15723172, ECO:0000269\|PubMed:21214543, ECO:0000269\|PubMed:24723458, ECO:0000303\|PubMed:18541522}.; FUNCTION: [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250\|UniProtKB:P26339}.
P15822	HIVEP1	S2341	ochoa	Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)	This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P17275	JUNB	Y182	psp	Transcription factor JunB (Transcription factor AP-1 subunit JunB)	Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250\|UniProtKB:P09450}.
P17661	DES	S42	ochoa	Desmin	Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250\|UniProtKB:P31001, ECO:0000269\|PubMed:24200904, ECO:0000269\|PubMed:25394388, ECO:0000269\|PubMed:26724190, ECO:0000303\|PubMed:25358400}.
P19622	EN2	S150	ochoa	Homeobox protein engrailed-2 (Homeobox protein en-2) (Hu-En-2)	None
P20749	BCL3	S122	psp	B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)	Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8453667}.
P20823	HNF1A	S303	ochoa	Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)	Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250\|UniProtKB:P22361, ECO:0000269\|PubMed:10966642, ECO:0000269\|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269\|PubMed:14728801, ECO:0000269\|PubMed:38018242}.
P21333	FLNA	S2558	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21860	ERBB3	S1094	ochoa	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269\|PubMed:15358134, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:27416908}.
P23497	SP100	S205	ochoa	Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269\|PubMed:11909962, ECO:0000269\|PubMed:14647468, ECO:0000269\|PubMed:15247905, ECO:0000269\|PubMed:15592518, ECO:0000269\|PubMed:15767676, ECO:0000269\|PubMed:16177824, ECO:0000269\|PubMed:17245429, ECO:0000269\|PubMed:21274506, ECO:0000269\|PubMed:21880768}.
P23588	EIF4B	S589	ochoa	Eukaryotic translation initiation factor 4B (eIF-4B)	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P24928	POLR2A	S1532	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1847	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1896	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1931	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1938	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P25054	APC	S2337	ochoa	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250\|UniProtKB:Q61315, ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:17293347, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19151759, ECO:0000269\|PubMed:19893577, ECO:0000269\|PubMed:20937854}.
P26358	DNMT1	S141	ochoa	DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)	Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269\|PubMed:16357870, ECO:0000269\|PubMed:18413740, ECO:0000269\|PubMed:18754681, ECO:0000269\|PubMed:24623306}.
P26651	ZFP36	S228	psp	mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250\|UniProtKB:P22893, ECO:0000269\|PubMed:10330172, ECO:0000269\|PubMed:10751406, ECO:0000269\|PubMed:11279239, ECO:0000269\|PubMed:11719186, ECO:0000269\|PubMed:12115244, ECO:0000269\|PubMed:12748283, ECO:0000269\|PubMed:15187101, ECO:0000269\|PubMed:15634918, ECO:0000269\|PubMed:15687258, ECO:0000269\|PubMed:15766526, ECO:0000269\|PubMed:16364915, ECO:0000269\|PubMed:16702957, ECO:0000269\|PubMed:17030620, ECO:0000269\|PubMed:17369404, ECO:0000269\|PubMed:18367721, ECO:0000269\|PubMed:19188452, ECO:0000269\|PubMed:20221403, ECO:0000269\|PubMed:20702587, ECO:0000269\|PubMed:21775632, ECO:0000269\|PubMed:23644599, ECO:0000269\|PubMed:25815583, ECO:0000269\|PubMed:26926077, ECO:0000269\|PubMed:27182009, ECO:0000269\|PubMed:27193233, ECO:0000269\|PubMed:31439631, ECO:0000269\|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269\|PubMed:14679154}.
P28290	ITPRID2	S207	ochoa	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	None
P28290	ITPRID2	S944	ochoa	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	None
P35568	IRS1	S766	ochoa	Insulin receptor substrate 1 (IRS-1)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:11171109, ECO:0000269\|PubMed:16878150, ECO:0000269\|PubMed:19639489, ECO:0000269\|PubMed:38625937, ECO:0000269\|PubMed:7541045, ECO:0000269\|PubMed:8265614}.
P37275	ZEB1	S693	ochoa	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250\|UniProtKB:Q64318, ECO:0000269\|PubMed:19935649, ECO:0000269\|PubMed:20175752, ECO:0000269\|PubMed:20418909}.
P38159	RBMX	S173	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P38159	RBMX	S308	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P41235	HNF4A	S436	ochoa\|psp	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)	Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250\|UniProtKB:P49698, ECO:0000269\|PubMed:30530698, ECO:0000269\|PubMed:30597922}.
P41235	HNF4A	S443	psp	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)	Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250\|UniProtKB:P49698, ECO:0000269\|PubMed:30530698, ECO:0000269\|PubMed:30597922}.
P42226	STAT6	S707	psp	Signal transducer and activator of transcription 6 (IL-4 Stat)	Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269\|PubMed:17210636, ECO:0000269\|PubMed:36758835, ECO:0000269\|PubMed:36884218}.
P46109	CRKL	S114	ochoa\|psp	Crk-like protein	May mediate the transduction of intracellular signals.
P46777	RPL5	S187	ochoa	Large ribosomal subunit protein uL18 (60S ribosomal protein L5)	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269\|PubMed:12962325, ECO:0000269\|PubMed:19061985, ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:24120868}.
P46821	MAP1B	S2280	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46937	YAP1	S105	ochoa	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P47736	RAP1GAP	S498	ochoa	Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)	GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269\|PubMed:15141215}.
P49023	PXN	S336	ochoa	Paxillin	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269\|PubMed:25015296}.
P49792	RANBP2	S955	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	S2518	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49796	RGS3	S730	ochoa	Regulator of G-protein signaling 3 (RGP3) (RGS3)	Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269\|PubMed:10749886, ECO:0000269\|PubMed:11294858, ECO:0000269\|PubMed:8602223, ECO:0000269\|PubMed:9858594}.
P50479	PDLIM4	S132	ochoa	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)	[Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250\|UniProtKB:P36202, ECO:0000269\|PubMed:19307596, ECO:0000269\|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269\|PubMed:21636573}.
P51587	BRCA2	S3291	psp	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269\|PubMed:15115758, ECO:0000269\|PubMed:15199141, ECO:0000269\|PubMed:15671039, ECO:0000269\|PubMed:18317453, ECO:0000269\|PubMed:20729832, ECO:0000269\|PubMed:20729858, ECO:0000269\|PubMed:20729859, ECO:0000269\|PubMed:21084279, ECO:0000269\|PubMed:21719596, ECO:0000269\|PubMed:24485656, ECO:0000269\|PubMed:24896180}.
P51798	CLCN7	S48	ochoa	H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)	Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250\|UniProtKB:P35523, ECO:0000269\|PubMed:18449189, ECO:0000269\|PubMed:21527911, ECO:0000269\|PubMed:31155284}.
P52735	VAV2	S583	ochoa	Guanine nucleotide exchange factor VAV2 (VAV-2)	Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.
P53350	PLK1	S335	psp	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250\|UniProtKB:P70032, ECO:0000250\|UniProtKB:Q5F2C3, ECO:0000269\|PubMed:11202906, ECO:0000269\|PubMed:12207013, ECO:0000269\|PubMed:12447691, ECO:0000269\|PubMed:12524548, ECO:0000269\|PubMed:12738781, ECO:0000269\|PubMed:12852856, ECO:0000269\|PubMed:12939256, ECO:0000269\|PubMed:14532005, ECO:0000269\|PubMed:14734534, ECO:0000269\|PubMed:15070733, ECO:0000269\|PubMed:15148369, ECO:0000269\|PubMed:15469984, ECO:0000269\|PubMed:15661742, ECO:0000269\|PubMed:16198290, ECO:0000269\|PubMed:16247472, ECO:0000269\|PubMed:16980960, ECO:0000269\|PubMed:17081991, ECO:0000269\|PubMed:17218258, ECO:0000269\|PubMed:17351640, ECO:0000269\|PubMed:17376779, ECO:0000269\|PubMed:17617734, ECO:0000269\|PubMed:18174154, ECO:0000269\|PubMed:18331714, ECO:0000269\|PubMed:18418051, ECO:0000269\|PubMed:18477460, ECO:0000269\|PubMed:18521620, ECO:0000269\|PubMed:18615013, ECO:0000269\|PubMed:18662541, ECO:0000269\|PubMed:18794143, ECO:0000269\|PubMed:19160488, ECO:0000269\|PubMed:19351716, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19468302, ECO:0000269\|PubMed:19473992, ECO:0000269\|PubMed:19509060, ECO:0000269\|PubMed:19597481, ECO:0000269\|PubMed:20679239, ECO:0000269\|PubMed:21857149, ECO:0000269\|PubMed:21880710, ECO:0000269\|PubMed:22325354, ECO:0000269\|PubMed:23455478, ECO:0000269\|PubMed:23509069, ECO:0000269\|PubMed:25503564, ECO:0000269\|PubMed:25986610, ECO:0000269\|PubMed:26811421, ECO:0000269\|PubMed:27979967, ECO:0000269\|PubMed:37440612, ECO:0000269\|PubMed:37674080, ECO:0000269\|PubMed:8991084}.
P54259	ATN1	S182	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P54259	ATN1	S887	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P55055	NR1H2	S27	ochoa	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)	Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250\|UniProtKB:Q60644, ECO:0000269\|PubMed:20159957, ECO:0000269\|PubMed:25661920}.
P60484	PTEN	S380	psp	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)	Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubMed:9593664, PubMed:9811831). Furthermore, this enzyme can also act as a cytosolic inositol 3-phosphatase acting on Ins(1,3,4,5,6)P5/inositol 1,3,4,5,6 pentakisphosphate and possibly Ins(1,3,4,5)P4/1D-myo-inositol 1,3,4,5-tetrakisphosphate (PubMed:11418101, PubMed:15979280). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:31492966, PubMed:37279284). The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation (PubMed:11707428). In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049). Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces PTEN phosphorylation which changes its binding preference from the p85 regulatory subunit of the PI3K kinase complex to DLC1 and results in translocation of the PTEN-DLC1 complex to the posterior of migrating cells to promote RHOA activation (PubMed:26166433). Meanwhile, TNS3 switches binding preference from DLC1 to p85 and the TNS3-p85 complex translocates to the leading edge of migrating cells to activate RAC1 activation (PubMed:26166433). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Involved in the regulation of synaptic function in excitatory hippocampal synapses. Recruited to the postsynaptic membrane upon NMDA receptor activation, is required for the modulation of synaptic activity during plasticity. Enhancement of lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses, activity required for NMDA receptor-dependent long-term depression (LTD) (By similarity). May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability (PubMed:10468583, PubMed:18716620). {ECO:0000250\|UniProtKB:O08586, ECO:0000250\|UniProtKB:O54857, ECO:0000269\|PubMed:10468583, ECO:0000269\|PubMed:11418101, ECO:0000269\|PubMed:11707428, ECO:0000269\|PubMed:15979280, ECO:0000269\|PubMed:16824732, ECO:0000269\|PubMed:18716620, ECO:0000269\|PubMed:22279049, ECO:0000269\|PubMed:26166433, ECO:0000269\|PubMed:26504226, ECO:0000269\|PubMed:31492966, ECO:0000269\|PubMed:37279284, ECO:0000269\|PubMed:9187108, ECO:0000269\|PubMed:9256433, ECO:0000269\|PubMed:9593664, ECO:0000269\|PubMed:9616126, ECO:0000269\|PubMed:9811831}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. {ECO:0000269\|PubMed:23744781}.
P85037	FOXK1	S257	ochoa	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250\|UniProtKB:P42128, ECO:0000269\|PubMed:17670796, ECO:0000269\|PubMed:24634419, ECO:0000269\|PubMed:25805136, ECO:0000269\|PubMed:25852164, ECO:0000269\|PubMed:30664650}.
Q03164	KMT2A	S2508	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q07889	SOS1	S1229	ochoa	Son of sevenless homolog 1 (SOS-1)	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250\|UniProtKB:Q62245, ECO:0000269\|PubMed:17339331, ECO:0000269\|PubMed:8493579}.
Q08AD1	CAMSAP2	S1019	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q08AD1	CAMSAP2	S1290	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q09666	AHNAK	S4908	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5289	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5552	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	S5651	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q12774	ARHGEF5	S468	ochoa	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250\|UniProtKB:E9Q7D5, ECO:0000269\|PubMed:14662653, ECO:0000269\|PubMed:15601624}.
Q12789	GTF3C1	S1962	ochoa	General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
Q12888	TP53BP1	S380	ochoa\|psp	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q12946	FOXF1	S335	ochoa	Forkhead box protein F1 (Forkhead-related activator 1) (FREAC-1) (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1)	Probable transcription activator for a number of lung-specific genes.
Q13330	MTA1	S558	ochoa	Metastasis-associated protein MTA1	Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250\|UniProtKB:Q8K4B0, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:17671180, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:21965678, ECO:0000269\|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269\|PubMed:15077195}.
Q13428	TCOF1	S1102	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13487	SNAPC2	S192	ochoa	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit)	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Q13501	SQSTM1	S224	ochoa	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)	Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250\|UniProtKB:Q64337, ECO:0000269\|PubMed:10356400, ECO:0000269\|PubMed:10747026, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:12471037, ECO:0000269\|PubMed:15340068, ECO:0000269\|PubMed:15802564, ECO:0000269\|PubMed:15911346, ECO:0000269\|PubMed:15953362, ECO:0000269\|PubMed:16079148, ECO:0000269\|PubMed:16286508, ECO:0000269\|PubMed:17580304, ECO:0000269\|PubMed:19931284, ECO:0000269\|PubMed:20168092, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:22017874, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:24128730, ECO:0000269\|PubMed:25101860, ECO:0000269\|PubMed:26344566, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:28404643, ECO:0000269\|PubMed:29343546, ECO:0000269\|PubMed:29496741, ECO:0000269\|PubMed:29507397, ECO:0000269\|PubMed:31857589, ECO:0000269\|PubMed:33393215, ECO:0000269\|PubMed:33472082, ECO:0000269\|PubMed:33509017, ECO:0000269\|PubMed:34471133, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:35831301, ECO:0000269\|PubMed:37306101, ECO:0000269\|PubMed:37802024}.
Q13541	EIF4EBP1	S44	ochoa	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:22684010, ECO:0000269\|PubMed:7935836}.
Q13542	EIF4EBP2	S44	ochoa	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957, PubMed:30765518). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity). {ECO:0000250\|UniProtKB:P70445, ECO:0000269\|PubMed:25533957, ECO:0000269\|PubMed:30765518}.
Q13671	RIN1	S210	ochoa	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:9144171, ECO:0000269\|PubMed:9208849}.
Q13796	SHROOM2	S436	ochoa	Protein Shroom2 (Apical-like protein) (Protein APXL)	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13873	BMPR2	S765	ochoa	Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250\|UniProtKB:O35607, ECO:0000269\|PubMed:12045205, ECO:0000269\|PubMed:24018044}.
Q14202	ZMYM3	S186	ochoa	Zinc finger MYM-type protein 3 (Zinc finger protein 261)	Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269\|PubMed:21834987}.
Q14596	NBR1	S825	ochoa	Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)	Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:24692539, PubMed:33577621). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (PubMed:24879152, PubMed:34471133). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (PubMed:35914352). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity). {ECO:0000250\|UniProtKB:P97432, ECO:0000269\|PubMed:19250911, ECO:0000269\|PubMed:24692539, ECO:0000269\|PubMed:24879152, ECO:0000269\|PubMed:33577621, ECO:0000269\|PubMed:34471133, ECO:0000269\|PubMed:35914352}.
Q14687	GSE1	S186	ochoa	Genetic suppressor element 1	None
Q14738	PPP2R5D	S533	ochoa	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q14766	LTBP1	S446	ochoa	Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)	Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269\|PubMed:15184403, ECO:0000269\|PubMed:2022183, ECO:0000269\|PubMed:22278742, ECO:0000269\|PubMed:8617200, ECO:0000269\|PubMed:8939931}.
Q15025	TNIP1	S123	psp	TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)	Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269\|PubMed:12220502, ECO:0000269\|PubMed:16684768, ECO:0000269\|PubMed:17016622, ECO:0000269\|PubMed:17632516, ECO:0000269\|PubMed:20010814, ECO:0000269\|PubMed:21885437}.
Q15173	PPP2R5B	S20	ochoa	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta)	As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269\|PubMed:21329884}.
Q15326	ZMYND11	S419	ochoa	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)	Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250\|UniProtKB:Q8R5C8, ECO:0000269\|PubMed:10734313, ECO:0000269\|PubMed:16565076, ECO:0000269\|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269\|PubMed:26845565}.
Q15459	SF3A1	S413	ochoa	Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:11533230, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:30315277, ECO:0000269\|PubMed:32494006}.
Q15633	TARBP2	S156	ochoa	RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)	Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250\|UniProtKB:P97473, ECO:0000255\|HAMAP-Rule:MF_03034, ECO:0000269\|PubMed:15973356, ECO:0000269\|PubMed:16142218, ECO:0000269\|PubMed:16271387, ECO:0000269\|PubMed:16357216, ECO:0000269\|PubMed:16424907, ECO:0000269\|PubMed:17452327, ECO:0000269\|PubMed:18178619, ECO:0000269\|PubMed:23063653, ECO:0000269\|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269\|PubMed:11438532, ECO:0000269\|PubMed:12475984, ECO:0000269\|PubMed:2011739, ECO:0000269\|PubMed:30626973}.
Q15642	TRIP10	S335	ochoa	Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)	Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269\|PubMed:11069762, ECO:0000269\|PubMed:16318909, ECO:0000269\|PubMed:16326391}.
Q15648	MED1	S1447	ochoa	Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269\|PubMed:10406464, ECO:0000269\|PubMed:11867769, ECO:0000269\|PubMed:12037571, ECO:0000269\|PubMed:12218053, ECO:0000269\|PubMed:12556447, ECO:0000269\|PubMed:14636573, ECO:0000269\|PubMed:15340084, ECO:0000269\|PubMed:15471764, ECO:0000269\|PubMed:15989967, ECO:0000269\|PubMed:16574658, ECO:0000269\|PubMed:24245781, ECO:0000269\|PubMed:9653119}.
Q15678	PTPN14	S328	ochoa	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269\|PubMed:10934049, ECO:0000269\|PubMed:12808048, ECO:0000269\|PubMed:17893246, ECO:0000269\|PubMed:20826270, ECO:0000269\|PubMed:22233626, ECO:0000269\|PubMed:22525271, ECO:0000269\|PubMed:22948661}.
Q15772	SPEG	S334	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15772	SPEG	S540	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15853	USF2	S155	psp	Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)	Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Q15942	ZYX	S143	ochoa	Zyxin (Zyxin-2)	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q15942	ZYX	S202	ochoa	Zyxin (Zyxin-2)	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q15942	ZYX	S281	ochoa	Zyxin (Zyxin-2)	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q15942	ZYX	S288	ochoa	Zyxin (Zyxin-2)	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16512	PKN1	S603	ochoa	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)	PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269\|PubMed:11104762, ECO:0000269\|PubMed:12514133, ECO:0000269\|PubMed:17332740, ECO:0000269\|PubMed:18066052, ECO:0000269\|PubMed:20188095, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:21754995, ECO:0000269\|PubMed:24248594, ECO:0000269\|PubMed:8557118, ECO:0000269\|PubMed:8621664, ECO:0000269\|PubMed:9175763}.
Q16665	HIF1A	S465	psp	Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)	Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250\|UniProtKB:Q61221, ECO:0000269\|PubMed:10202154, ECO:0000269\|PubMed:10594042, ECO:0000269\|PubMed:11292861, ECO:0000269\|PubMed:11566883, ECO:0000269\|PubMed:15465032, ECO:0000269\|PubMed:16543236, ECO:0000269\|PubMed:16973622, ECO:0000269\|PubMed:17610843, ECO:0000269\|PubMed:18658046, ECO:0000269\|PubMed:19528298, ECO:0000269\|PubMed:20624928, ECO:0000269\|PubMed:22009797, ECO:0000269\|PubMed:30125331, ECO:0000269\|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269\|PubMed:32697943}.
Q16666	IFI16	S418	ochoa	Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)	Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269\|PubMed:11146555, ECO:0000269\|PubMed:12894224, ECO:0000269\|PubMed:14654789, ECO:0000269\|PubMed:20890285, ECO:0000269\|PubMed:21573174, ECO:0000269\|PubMed:21575908, ECO:0000269\|PubMed:22046441, ECO:0000269\|PubMed:22291595, ECO:0000269\|PubMed:23027953, ECO:0000269\|PubMed:24198334, ECO:0000269\|PubMed:24413532, ECO:0000269\|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269\|PubMed:30104205}.
Q2M3G4	SHROOM1	S186	ochoa	Protein Shroom1 (Apical protein 2)	May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q2M3G4	SHROOM1	S408	ochoa	Protein Shroom1 (Apical protein 2)	May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q2VPK5	CTU2	S435	ochoa	Cytoplasmic tRNA 2-thiolation protein 2 (Cytosolic thiouridylase subunit 2)	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255\|HAMAP-Rule:MF_03054, ECO:0000269\|PubMed:19017811}.
Q3KQU3	MAP7D1	S483	ochoa	MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)	Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250\|UniProtKB:A2AJI0}.
Q4KMQ1	TPRN	S278	ochoa	Taperin	Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250\|UniProtKB:A2AI08, ECO:0000269\|PubMed:23213405}.
Q58EX7	PLEKHG4	S677	ochoa	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)	Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Q5QJ74	TBCEL	S41	ochoa	Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35)	Acts as a regulator of tubulin stability. {ECO:0000269\|PubMed:15728251}.
Q5QP82	DCAF10	S63	ochoa	DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)	May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:16949367}.
Q5SW79	CEP170	S1529	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5T0Z8	C6orf132	S456	ochoa	Uncharacterized protein C6orf132	None
Q5T6C5	ATXN7L2	S475	ochoa	Ataxin-7-like protein 2	None
Q5T6C5	ATXN7L2	S632	ochoa	Ataxin-7-like protein 2	None
Q5TZA2	CROCC	S1490	ochoa	Rootletin (Ciliary rootlet coiled-coil protein)	Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250\|UniProtKB:Q8CJ40, ECO:0000269\|PubMed:16203858, ECO:0000269\|PubMed:27623382}.
Q5VT52	RPRD2	S785	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VT52	RPRD2	S816	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VT52	RPRD2	S976	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VWJ9	SNX30	S27	ochoa	Sorting nexin-30	Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:32513819). Together with SNX4, involved in autophagosome assembly (PubMed:32513819). {ECO:0000269\|PubMed:32513819}.
Q5VY43	PEAR1	S1009	ochoa	Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)	Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250\|UniProtKB:Q8VIK5, ECO:0000269\|PubMed:36792666}.
Q63HR2	TNS2	S832	ochoa	Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)	Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250\|UniProtKB:Q8CGB6, ECO:0000269\|PubMed:15817639, ECO:0000269\|PubMed:20069572, ECO:0000269\|PubMed:23401856, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:28955049, ECO:0000269\|PubMed:30092354}.
Q6ICG6	KIAA0930	S304	ochoa	Uncharacterized protein KIAA0930	None
Q6NZY4	ZCCHC8	S500	ochoa	Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)	Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269\|PubMed:27871484, ECO:0000269\|PubMed:31488579, ECO:0000305\|PubMed:16263084}.
Q6P0Q8	MAST2	S1358	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PCD5	RFWD3	S46	psp	E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)	E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:21504906, ECO:0000269\|PubMed:21558276, ECO:0000269\|PubMed:26474068, ECO:0000269\|PubMed:28575657, ECO:0000269\|PubMed:28575658, ECO:0000269\|PubMed:28691929, ECO:0000269\|PubMed:33321094}.
Q6PCD5	RFWD3	S63	psp	E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)	E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094). {ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:21504906, ECO:0000269\|PubMed:21558276, ECO:0000269\|PubMed:26474068, ECO:0000269\|PubMed:28575657, ECO:0000269\|PubMed:28575658, ECO:0000269\|PubMed:28691929, ECO:0000269\|PubMed:33321094}.
Q6PKG0	LARP1	S577	ochoa	La-related protein 1 (La ribonucleoprotein domain family member 1)	RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:23711370, ECO:0000269\|PubMed:24532714, ECO:0000269\|PubMed:25940091, ECO:0000269\|PubMed:26206669, ECO:0000269\|PubMed:28379136, ECO:0000269\|PubMed:28650797, ECO:0000269\|PubMed:28673543, ECO:0000269\|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269\|PubMed:26735137}.
Q6UUV9	CRTC1	S424	ochoa	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250\|UniProtKB:Q157S1, ECO:0000250\|UniProtKB:Q68ED7, ECO:0000269\|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:16809310}.
Q6UWF3	SCIMP	S90	ochoa	SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein)	Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250\|UniProtKB:Q3UU41, ECO:0000269\|PubMed:21930792}.
Q6VMQ6	ATF7IP	S854	ochoa	Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:14536086, ECO:0000269\|PubMed:19106100, ECO:0000269\|PubMed:27732843}.
Q6VN20	RANBP10	S369	ochoa	Ran-binding protein 10 (RanBP10)	May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250\|UniProtKB:Q6VN19, ECO:0000269\|PubMed:18222118, ECO:0000269\|PubMed:29911972, ECO:0000305}.
Q6VN20	RANBP10	S376	ochoa	Ran-binding protein 10 (RanBP10)	May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250\|UniProtKB:Q6VN19, ECO:0000269\|PubMed:18222118, ECO:0000269\|PubMed:29911972, ECO:0000305}.
Q6ZRS2	SRCAP	S1944	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q6ZUM4	ARHGAP27	S455	ochoa	Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)	Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q70CQ2	USP34	S3411	ochoa	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269\|PubMed:21383061}.
Q70E73	RAPH1	S979	ochoa	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)	Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q711Q0	CEFIP	S1246	ochoa	Cardiac-enriched FHL2-interacting protein	Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250\|UniProtKB:M0RD54}.
Q7Z2K8	GPRIN1	S100	ochoa	G protein-regulated inducer of neurite outgrowth 1 (GRIN1)	May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z2Z1	TICRR	S1141	ochoa	Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)	Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269\|PubMed:20116089}.
Q7Z309	PABIR2	S119	ochoa	PABIR family member 2	None
Q7Z5L9	IRF2BP2	S406	ochoa	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269\|PubMed:12799427, ECO:0000269\|PubMed:20702774, ECO:0000269\|PubMed:21576369, ECO:0000269\|PubMed:27016798}.
Q7Z6Z7	HUWE1	S2926	ochoa	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250\|UniProtKB:P51593, ECO:0000250\|UniProtKB:Q7TMY8, ECO:0000269\|PubMed:15567145, ECO:0000269\|PubMed:15767685, ECO:0000269\|PubMed:15989956, ECO:0000269\|PubMed:15989957, ECO:0000269\|PubMed:17567951, ECO:0000269\|PubMed:18488021, ECO:0000269\|PubMed:19037095, ECO:0000269\|PubMed:19713937, ECO:0000269\|PubMed:20534529, ECO:0000269\|PubMed:26214738, ECO:0000269\|PubMed:27746020, ECO:0000269\|PubMed:30217973, ECO:0000269\|PubMed:35776542}.
Q86SQ0	PHLDB2	S565	ochoa	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12376540}.
Q86UU0	BCL9L	S1073	ochoa	B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2)	Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q86VM9	ZC3H18	S791	ochoa	Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)	None
Q86X10	RALGAPB	S377	ochoa	Ral GTPase-activating protein subunit beta (p170)	Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Q86XN7	PROSER1	S617	ochoa	Proline and serine-rich protein 1	Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). {ECO:0000269\|PubMed:34667079}.
Q86YN6	PPARGC1B	S263	ochoa	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269\|PubMed:11854298, ECO:0000269\|PubMed:12678921, ECO:0000269\|PubMed:15546003, ECO:0000269\|PubMed:23836911}.
Q86YN6	PPARGC1B	S384	ochoa	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269\|PubMed:11854298, ECO:0000269\|PubMed:12678921, ECO:0000269\|PubMed:15546003, ECO:0000269\|PubMed:23836911}.
Q8IV63	VRK3	S136	ochoa\|psp	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IVF2	AHNAK2	S56	ochoa	Protein AHNAK2	None
Q8IVF2	AHNAK2	S1112	ochoa	Protein AHNAK2	None
Q8IVF2	AHNAK2	S4419	ochoa	Protein AHNAK2	None
Q8IWE5	PLEKHM2	S371	ochoa	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)	Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:22172677, ECO:0000269\|PubMed:24088571, ECO:0000269\|PubMed:25898167, ECO:0000269\|PubMed:28325809}.
Q8IWE5	PLEKHM2	S766	ochoa	Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)	Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:22172677, ECO:0000269\|PubMed:24088571, ECO:0000269\|PubMed:25898167, ECO:0000269\|PubMed:28325809}.
Q8IX07	ZFPM1	S638	ochoa	Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IY81	FTSJ3	S598	ochoa	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255\|HAMAP-Rule:MF_03163, ECO:0000269\|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269\|PubMed:30626973}.
Q8IYB3	SRRM1	S227	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8IZ21	PHACTR4	S177	ochoa	Phosphatase and actin regulator 4	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZD4	DCP1B	S511	ochoa	mRNA-decapping enzyme 1B (EC 3.6.1.62)	May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250\|UniProtKB:Q9NPI6}.
Q8IZL2	MAML2	S471	ochoa	Mastermind-like protein 2 (Mam-2)	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. {ECO:0000269\|PubMed:12370315, ECO:0000269\|PubMed:12386158, ECO:0000269\|PubMed:12539049}.
Q8IZP0	ABI1	S216	ochoa\|psp	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269\|PubMed:11003655, ECO:0000269\|PubMed:18328268}.
Q8N183	NDUFAF2	S149	ochoa	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein)	Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211, PubMed:19384974). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). Is involved in the initial steps of cilia formation, including removal of CP110 from the mother centrioles, docking of membrane vesicles to the mother centrioles, and establishment of the transition zone (PubMed:38949024). {ECO:0000269\|PubMed:16200211, ECO:0000269\|PubMed:19384974, ECO:0000269\|PubMed:27626371, ECO:0000269\|PubMed:38949024}.
Q8N1F8	STK11IP	S404	psp	Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)	May regulate STK11/LKB1 function by controlling its subcellular localization. {ECO:0000269\|PubMed:11741830}.
Q8N1G1	REXO1	S365	ochoa	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1)	Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269\|PubMed:12943681}.
Q8N3F8	MICALL1	S309	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3F8	MICALL1	S493	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3F8	MICALL1	S513	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3L3	TXLNB	S554	ochoa	Beta-taxilin (Muscle-derived protein 77) (hMDP77)	Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}.
Q8N4C8	MINK1	S555	ochoa	Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250\|UniProtKB:F1LP90, ECO:0000250\|UniProtKB:Q9JM52, ECO:0000269\|PubMed:10708748, ECO:0000269\|PubMed:16337592, ECO:0000269\|PubMed:18930710, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N4C8	MINK1	S601	ochoa	Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250\|UniProtKB:F1LP90, ECO:0000250\|UniProtKB:Q9JM52, ECO:0000269\|PubMed:10708748, ECO:0000269\|PubMed:16337592, ECO:0000269\|PubMed:18930710, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N4L2	PIP4P2	S47	ochoa	Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)	Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250\|UniProtKB:Q9CZX7, ECO:0000269\|PubMed:16365287}.
Q8N684	CPSF7	Y74	ochoa	Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)	Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269\|PubMed:17024186, ECO:0000269\|PubMed:20695905, ECO:0000269\|PubMed:23187700, ECO:0000269\|PubMed:29276085, ECO:0000269\|PubMed:8626397}.
Q8N6H7	ARFGAP2	S368	ochoa	ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289)	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269\|PubMed:17760859}.
Q8N7J2	AMER2	S233	ochoa	APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)	Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269\|PubMed:22128170}.
Q8NAX2	KDF1	S209	ochoa	Keratinocyte differentiation factor 1	Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250\|UniProtKB:A2A9F4}.
Q8NBZ0	INO80E	S106	ochoa	INO80 complex subunit E (Coiled-coil domain-containing protein 95)	Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Q8NC74	RBBP8NL	S392	ochoa	RBBP8 N-terminal-like protein	None
Q8ND04	SMG8	S668	ochoa	Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269\|PubMed:19417104}.
Q8NDI1	EHBP1	S302	ochoa	EH domain-binding protein 1	May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250\|UniProtKB:Q69ZW3, ECO:0000269\|PubMed:14676205, ECO:0000305\|PubMed:27552051}.
Q8NEZ4	KMT2C	S3526	ochoa	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:24081332, ECO:0000269\|PubMed:25561738}.
Q8NHV4	NEDD1	S557	psp	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19509060}.
Q8TAP9	MPLKIP	S66	ochoa	M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein)	May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269\|PubMed:17310276}.
Q8TBC3	SHKBP1	S161	ochoa	SH3KBP1-binding protein 1 (SETA-binding protein 1)	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250\|UniProtKB:Q6P7W2}.
Q8TD19	NEK9	S836	ochoa	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)	Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269\|PubMed:11864968, ECO:0000269\|PubMed:12101123, ECO:0000269\|PubMed:12840024, ECO:0000269\|PubMed:14660563, ECO:0000269\|PubMed:19941817, ECO:0000269\|PubMed:26522158}.
Q8TF76	HASPIN	S188	psp	Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)	Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269\|PubMed:11228240, ECO:0000269\|PubMed:15681610, ECO:0000269\|PubMed:17084365, ECO:0000269\|PubMed:20705812, ECO:0000269\|PubMed:20929775}.
Q8WXD9	CASKIN1	S826	ochoa	Caskin-1 (CASK-interacting protein 1)	May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXE9	STON2	S269	ochoa	Stonin-2 (Stoned B)	Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269\|PubMed:11381094, ECO:0000269\|PubMed:11454741, ECO:0000269\|PubMed:21102408}.
Q8WXG6	MADD	S935	ochoa	MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)	Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064). {ECO:0000250\|UniProtKB:O08873, ECO:0000250\|UniProtKB:Q80U28, ECO:0000269\|PubMed:11577081, ECO:0000269\|PubMed:18559336, ECO:0000269\|PubMed:20937701, ECO:0000269\|PubMed:32761064, ECO:0000269\|PubMed:9115275}.
Q8WXI9	GATAD2B	S313	ochoa	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2A (PubMed:16415179). Targets MBD3 to discrete loci in the nucleus (PubMed:11756549). May play a role in synapse development (PubMed:23644463). {ECO:0000269\|PubMed:11756549, ECO:0000269\|PubMed:12183469, ECO:0000269\|PubMed:16415179, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:23644463, ECO:0000269\|PubMed:28977666}.
Q92576	PHF3	S868	ochoa	PHD finger protein 3	None
Q92619	ARHGAP45	S949	ochoa	Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)]	Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269\|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269\|PubMed:12601144, ECO:0000269\|PubMed:8260714, ECO:0000269\|PubMed:8532022, ECO:0000269\|PubMed:9798702}.
Q92622	RUBCN	S671	ochoa	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)	Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). {ECO:0000269\|PubMed:20974968, ECO:0000269\|PubMed:21062745}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967). {ECO:0000269\|PubMed:22423966, ECO:0000269\|PubMed:22423967}.
Q92733	PRCC	S97	ochoa	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)	May regulate cell cycle progression through interaction with MAD2L2. {ECO:0000269\|PubMed:11717438}.
Q92738	USP6NL	S798	ochoa	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269\|PubMed:11099046, ECO:0000269\|PubMed:17562788, ECO:0000269\|PubMed:17684057}.
Q92888	ARHGEF1	S863	ochoa	Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)	Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250\|UniProtKB:Q61210, ECO:0000269\|PubMed:20098430, ECO:0000269\|PubMed:30521495, ECO:0000269\|PubMed:8810315, ECO:0000269\|PubMed:9641915, ECO:0000269\|PubMed:9641916}.
Q96AP7	ESAM	S368	ochoa	Endothelial cell-selective adhesion molecule	Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250\|UniProtKB:Q925F2}.
Q96C90	PPP1R14B	S32	ochoa	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein)	Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). {ECO:0000250}.
Q96CJ1	EAF2	S151	ochoa	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)	Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269\|PubMed:12446457, ECO:0000269\|PubMed:12907652, ECO:0000269\|PubMed:16006523}.
Q96E39	RBMXL1	S161	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96E39	RBMXL1	S173	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96E39	RBMXL1	S308	ochoa	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96EC8	YIPF6	S24	ochoa	Protein YIPF6 (YIP1 family member 6)	May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269\|PubMed:28286305}.
Q96EP0	RNF31	S451	ochoa	E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)	E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269\|PubMed:17006537, ECO:0000269\|PubMed:19136968, ECO:0000269\|PubMed:20005846, ECO:0000269\|PubMed:21455173, ECO:0000269\|PubMed:21455180, ECO:0000269\|PubMed:21455181, ECO:0000269\|PubMed:22863777, ECO:0000269\|PubMed:23708998, ECO:0000269\|PubMed:27458237, ECO:0000269\|PubMed:27777308, ECO:0000269\|PubMed:28189684, ECO:0000269\|PubMed:28481331, ECO:0000269\|PubMed:34012115}.
Q96EY8	MMAB	S179	ochoa	Corrinoid adenosyltransferase MMAB (EC 2.5.1.-) (ATP:co(I)rrinoid adenosyltransferase MMAB) (Methylmalonic aciduria type B protein)	Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191). Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable). {ECO:0000269\|PubMed:12514191, ECO:0000305\|PubMed:28497574}.
Q96HH9	GRAMD2B	S58	ochoa	GRAM domain-containing protein 2B (HCV NS3-transactivated protein 2)	None
Q96IF1	AJUBA	S69	ochoa	LIM domain-containing protein ajuba	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269\|PubMed:12417594, ECO:0000269\|PubMed:13678582, ECO:0000269\|PubMed:15870274, ECO:0000269\|PubMed:16413547, ECO:0000269\|PubMed:17909014, ECO:0000269\|PubMed:18805794, ECO:0000269\|PubMed:20303269, ECO:0000269\|PubMed:20616046, ECO:0000269\|PubMed:22286099}.
Q96IF1	AJUBA	S119	ochoa\|psp	LIM domain-containing protein ajuba	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269\|PubMed:12417594, ECO:0000269\|PubMed:13678582, ECO:0000269\|PubMed:15870274, ECO:0000269\|PubMed:16413547, ECO:0000269\|PubMed:17909014, ECO:0000269\|PubMed:18805794, ECO:0000269\|PubMed:20303269, ECO:0000269\|PubMed:20616046, ECO:0000269\|PubMed:22286099}.
Q96II8	LRCH3	S583	ochoa	DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)	As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. {ECO:0000269\|PubMed:29467281}.
Q96JC9	EAF1	S165	ochoa	ELL-associated factor 1	Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269\|PubMed:11418481, ECO:0000269\|PubMed:16006523}.
Q96JH7	VCPIP1	S768	ochoa\|psp	Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)	Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250\|UniProtKB:Q8CF97, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269\|PubMed:28584101}.
Q96JM2	ZNF462	S1451	ochoa	Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)	Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250\|UniProtKB:B1AWL2, ECO:0000269\|PubMed:20219459, ECO:0000269\|PubMed:21570965}.
Q96JM3	CHAMP1	S267	ochoa	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269\|PubMed:21063390}.
Q96KQ7	EHMT2	S133	ochoa	Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250\|UniProtKB:Q9Z148, ECO:0000269\|PubMed:11316813, ECO:0000269\|PubMed:18438403, ECO:0000269\|PubMed:20084102, ECO:0000269\|PubMed:20118233, ECO:0000269\|PubMed:22387026, ECO:0000269\|PubMed:8457211}.
Q96KQ7	EHMT2	S569	ochoa\|psp	Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)	Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250\|UniProtKB:Q9Z148, ECO:0000269\|PubMed:11316813, ECO:0000269\|PubMed:18438403, ECO:0000269\|PubMed:20084102, ECO:0000269\|PubMed:20118233, ECO:0000269\|PubMed:22387026, ECO:0000269\|PubMed:8457211}.
Q96L14	CEP170P1	S238	ochoa	Cep170-like protein (CEP170 pseudogene 1)	None
Q96N67	DOCK7	S873	ochoa	Dedicator of cytokinesis protein 7	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250\|UniProtKB:Q8R1A4, ECO:0000269\|PubMed:16982419, ECO:0000269\|PubMed:29467281}.
Q96P48	ARAP1	S738	ochoa	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)	Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (PubMed:11804590, PubMed:19666464). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (PubMed:11804590). Has a preference for ARF1 and ARF5 (PubMed:11804590, PubMed:19666464). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (PubMed:22573888). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (By similarity). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (By similarity). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (By similarity). Regulates the endocytic trafficking of EGFR (PubMed:18764928, PubMed:18939958, PubMed:21275903). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (PubMed:38682696). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (By similarity). {ECO:0000250\|UniProtKB:Q4LDD4, ECO:0000269\|PubMed:11804590, ECO:0000269\|PubMed:18764928, ECO:0000269\|PubMed:18939958, ECO:0000269\|PubMed:19666464, ECO:0000269\|PubMed:21275903, ECO:0000269\|PubMed:22573888, ECO:0000269\|PubMed:38682696}.
Q96RT7	TUBGCP6	S1304	ochoa	Gamma-tubulin complex component 6 (GCP-6)	Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269\|PubMed:11694571, ECO:0000269\|PubMed:38305685, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
Q96ST3	SIN3A	S274	ochoa	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250\|UniProtKB:Q60520, ECO:0000269\|PubMed:12150998}.
Q96T58	SPEN	S3466	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q99501	GAS2L1	S620	ochoa	GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1)	Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269\|PubMed:12584248, ECO:0000269\|PubMed:24706950}.
Q99569	PKP4	Y261	ochoa	Plakophilin-4 (p0071)	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269\|PubMed:17115030}.
Q99593	TBX5	S41	ochoa	T-box transcription factor TBX5 (T-box protein 5)	DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:26917986, PubMed:27035640, PubMed:29174768, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). {ECO:0000269\|PubMed:25725155, ECO:0000269\|PubMed:25963046, ECO:0000269\|PubMed:26917986, ECO:0000269\|PubMed:26926761, ECO:0000269\|PubMed:27035640, ECO:0000269\|PubMed:29174768, ECO:0000269\|PubMed:8988164}.
Q99698	LYST	S2088	ochoa	Lysosomal-trafficking regulator (Beige homolog)	Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (PubMed:11984006, PubMed:25216107). Might regulate trafficking of effectors involved in exocytosis (PubMed:25425525). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (PubMed:26478006). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (By similarity). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250\|UniProtKB:P97412, ECO:0000269\|PubMed:11984006, ECO:0000269\|PubMed:25216107, ECO:0000269\|PubMed:25425525, ECO:0000269\|PubMed:26478006, ECO:0000269\|PubMed:27881733}.
Q99700	ATXN2	S667	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q99700	ATXN2	S1213	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q9BST9	RTKN	S543	ochoa	Rhotekin	Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269\|PubMed:10940294, ECO:0000269\|PubMed:15480428, ECO:0000269\|PubMed:16007136}.
Q9BUA3	SPINDOC	S248	ochoa	Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC)	Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269\|PubMed:33574238, ECO:0000269\|PubMed:34737271}.
Q9BW72	HIGD2A	S25	ochoa	HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b)	Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes. {ECO:0000269\|PubMed:22342701}.
Q9BWH6	RPAP1	S80	ochoa	RNA polymerase II-associated protein 1	Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269\|PubMed:17643375}.
Q9BZ72	PITPNM2	S894	ochoa	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269\|PubMed:10022914}.
Q9BZ95	NSD3	S561	ochoa	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)	Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269\|PubMed:16682010}.
Q9BZ95	NSD3	S568	ochoa	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)	Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269\|PubMed:16682010}.
Q9BZI1	IRX2	S317	ochoa	Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2)	None
Q9C0B0	UNK	S336	psp	RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5)	Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269\|PubMed:25737280}.
Q9C0B5	ZDHHC5	S529	ochoa	Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250\|UniProtKB:Q8VDZ4, ECO:0000269\|PubMed:21820437, ECO:0000269\|PubMed:26334723, ECO:0000269\|PubMed:29185452, ECO:0000269\|PubMed:31402609, ECO:0000269\|PubMed:31649195, ECO:0000269\|PubMed:32958780, ECO:0000269\|PubMed:34293401, ECO:0000269\|PubMed:38092000, ECO:0000269\|PubMed:38530158, ECO:0000269\|PubMed:38599239}.
Q9C0H5	ARHGAP39	S251	ochoa	Rho GTPase-activating protein 39	None
Q9GZV5	WWTR1	S62	ochoa	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269\|PubMed:11118213, ECO:0000269\|PubMed:18227151, ECO:0000269\|PubMed:18568018, ECO:0000269\|PubMed:19010321, ECO:0000269\|PubMed:23911299}.
Q9H1K0	RBSN	S592	ochoa	Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)	Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269\|PubMed:11062261, ECO:0000269\|PubMed:11788822, ECO:0000269\|PubMed:15020713, ECO:0000269\|PubMed:22308388}.
Q9H330	TMEM245	S30	ochoa	Transmembrane protein 245 (Protein CG-2)	None
Q9H6K5	PRR36	S1123	ochoa	Proline-rich protein 36	None
Q9H792	PEAK1	S823	ochoa	Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)	Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269\|PubMed:20534451, ECO:0000269\|PubMed:23105102, ECO:0000269\|PubMed:23846654, ECO:0000269\|PubMed:35687021}.
Q9HB58	SP110	S157	ochoa	Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)	Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HCE3	ZNF532	S314	ochoa	Zinc finger protein 532	May be involved in transcriptional regulation.
Q9HCK8	CHD8	S2218	ochoa	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255\|HAMAP-Rule:MF_03071, ECO:0000269\|PubMed:17938208, ECO:0000269\|PubMed:18378692, ECO:0000269\|PubMed:28533432, ECO:0000269\|PubMed:36537238}.
Q9HCM1	RESF1	S1255	ochoa	Retroelement silencing factor 1	Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250\|UniProtKB:Q5DTW7}.
Q9NP71	MLXIPL	S602	ochoa	Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)	Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (By similarity). {ECO:0000250\|UniProtKB:Q2VPU4, ECO:0000250\|UniProtKB:Q9HAP2}.
Q9NPG3	UBN1	S734	ochoa	Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)	Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:19029251}.
Q9NPI6	DCP1A	S367	ochoa	mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269\|PubMed:11836524, ECO:0000269\|PubMed:12417715, ECO:0000269\|PubMed:33813271}.
Q9NQ75	CASS4	S305	ochoa	Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)	Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269\|PubMed:18256281}.
Q9NQC3	RTN4	S182	ochoa	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269\|PubMed:24262037, ECO:0000269\|PubMed:25612671, ECO:0000269\|PubMed:26906412, ECO:0000269\|PubMed:27619977, ECO:0000269\|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:10667797, ECO:0000269\|PubMed:11201742, ECO:0000269\|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:11126360, ECO:0000269\|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:16965550}.
Q9NQS1	AVEN	S277	ochoa	Cell death regulator Aven	Protects against apoptosis mediated by Apaf-1.
Q9NQU5	PAK6	S165	ochoa\|psp	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269\|PubMed:14573606, ECO:0000269\|PubMed:20054820}.
Q9NR48	ASH1L	S918	ochoa	Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)	Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250\|UniProtKB:Q99MY8, ECO:0000269\|PubMed:21239497}.
Q9NVR5	DNAAF2	S240	ochoa	Protein kintoun (Dynein assembly factor 2, axonemal)	Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255\|HAMAP-Rule:MF_03069}.
Q9NZB2	FAM120A	S435	ochoa	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A)	Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269\|PubMed:19015244}.
Q9P1Y6	PHRF1	S1371	ochoa	PHD and RING finger domain-containing protein 1	None
Q9P266	JCAD	S719	ochoa	Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD)	None
Q9P266	JCAD	S1002	ochoa	Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD)	None
Q9P2R6	RERE	S955	ochoa	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein)	Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269\|PubMed:11331249}.
Q9UBC2	EPS15L1	S804	ochoa	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.
Q9UBF9	MYOT	S29	ochoa	Myotilin (57 kDa cytoskeletal protein) (Myofibrillar titin-like Ig domains protein) (Titin immunoglobulin domain protein)	Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. {ECO:0000269\|PubMed:12499399}.
Q9UBW5	BIN2	S349	ochoa	Bridging integrator 2 (Breast cancer-associated protein 1)	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269\|PubMed:23285027}.
Q9UFD9	RIMBP3	S1228	ochoa	RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1)	Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250\|UniProtKB:Q3V0F0}.
Q9UGP4	LIMD1	S298	ochoa	LIM domain-containing protein 1	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269\|PubMed:15542589, ECO:0000269\|PubMed:20303269, ECO:0000269\|PubMed:20616046, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:22286099}.
Q9UHV7	MED13	S481	ochoa	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:16595664}.
Q9UIS9	MBD1	S311	ochoa	Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)	Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269\|PubMed:10454587, ECO:0000269\|PubMed:10648624, ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:12697822, ECO:0000269\|PubMed:12711603, ECO:0000269\|PubMed:14555760, ECO:0000269\|PubMed:14610093, ECO:0000269\|PubMed:9207790, ECO:0000269\|PubMed:9774669}.
Q9UJX2	CDC23	S576	ochoa	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
Q9UKL3	CASP8AP2	S1672	ochoa	CASP8-associated protein 2 (FLICE-associated huge protein)	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Q9UKY7	CDV3	S166	ochoa	Protein CDV3 homolog	None
Q9ULC0	EMCN	S237	ochoa	Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14)	Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Q9ULM3	YEATS2	S545	ochoa	YEATS domain-containing protein 2	Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). {ECO:0000269\|PubMed:18838386, ECO:0000269\|PubMed:19103755, ECO:0000269\|PubMed:27103431}.
Q9ULV3	CIZ1	S578	ochoa	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	May regulate the subcellular localization of CIP/WAF1.
Q9UMS4	PRPF19	S149	ochoa\|psp	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)	Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity). {ECO:0000250\|UniProtKB:Q99KP6, ECO:0000250\|UniProtKB:Q9JMJ4, ECO:0000269\|PubMed:11082287, ECO:0000269\|PubMed:11435423, ECO:0000269\|PubMed:12960389, ECO:0000269\|PubMed:15660529, ECO:0000269\|PubMed:16223718, ECO:0000269\|PubMed:16332694, ECO:0000269\|PubMed:16388800, ECO:0000269\|PubMed:17349974, ECO:0000269\|PubMed:18263876, ECO:0000269\|PubMed:21536736, ECO:0000269\|PubMed:24332808, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:30705154, ECO:0000303\|PubMed:17981804, ECO:0000303\|PubMed:20595234}.
Q9UMS6	SYNPO2	S1063	ochoa	Synaptopodin-2 (Genethonin-2) (Myopodin)	Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250\|UniProtKB:D4A702, ECO:0000250\|UniProtKB:Q91YE8, ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:23225103, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213, ECO:0000305\|PubMed:16885336, ECO:0000305\|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269\|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269\|PubMed:22915763, ECO:0000269\|PubMed:24005909, ECO:0000269\|PubMed:25883213}.
Q9UNF0	PACSIN2	S305	ochoa	Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)	Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250\|UniProtKB:Q9WVE8, ECO:0000269\|PubMed:21693584, ECO:0000269\|PubMed:23129763, ECO:0000269\|PubMed:23236520, ECO:0000269\|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269\|PubMed:29891700, ECO:0000269\|PubMed:31242077, ECO:0000269\|PubMed:31801866}.
Q9UNF0	PACSIN2	S354	ochoa	Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)	Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250\|UniProtKB:Q9WVE8, ECO:0000269\|PubMed:21693584, ECO:0000269\|PubMed:23129763, ECO:0000269\|PubMed:23236520, ECO:0000269\|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269\|PubMed:29891700, ECO:0000269\|PubMed:31242077, ECO:0000269\|PubMed:31801866}.
Q9UPS6	SETD1B	S395	ochoa	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250\|UniProtKB:Q8CFT2, ECO:0000269\|PubMed:17355966, ECO:0000269\|PubMed:25561738}.
Q9UPT8	ZC3H4	S679	ochoa	Zinc finger CCCH domain-containing protein 4	RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269\|PubMed:33767452, ECO:0000269\|PubMed:33913806}.
Q9Y2H5	PLEKHA6	S384	ochoa	Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)	None
Q9Y2W1	THRAP3	S408	ochoa	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269\|PubMed:20123736, ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.
Q9Y314	NOSIP	S152	ochoa	Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein)	E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250\|UniProtKB:Q9D6T0, ECO:0000269\|PubMed:11149895, ECO:0000269\|PubMed:15548660, ECO:0000269\|PubMed:16135813}.
Q9Y3X0	CCDC9	S390	ochoa	Coiled-coil domain-containing protein 9	Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305\|PubMed:33973408}.
Q9Y4B5	MTCL1	S1319	ochoa	Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)	Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269\|PubMed:23902687, ECO:0000269\|PubMed:33587225}.
Q9Y4F1	FARP1	S23	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)	Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y4F5	CEP170B	S492	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y4F5	CEP170B	S718	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y4H2	IRS2	S594	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y4R8	TELO2	S639	ochoa	Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)	Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269\|PubMed:12670948, ECO:0000269\|PubMed:20810650}.
Q9Y6G9	DYNC1LI1	S412	ochoa	Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269\|PubMed:19229290, ECO:0000269\|PubMed:20026645}.
Q9Y6J0	CABIN1	S2159	ochoa	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:9655484}.
Q9Y6J9	TAF6L	S481	ochoa	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha)	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250\|UniProtKB:Q8R2K4, ECO:0000305\|PubMed:9674419}.
Q7Z4V5	HDGFL2	S300	Sugiyama	Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)	Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719). {ECO:0000269\|PubMed:25689719, ECO:0000269\|PubMed:26721387, ECO:0000269\|PubMed:32459350}.
Q16719	KYNU	S443	Sugiyama	Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269\|PubMed:11985583, ECO:0000269\|PubMed:17300176, ECO:0000269\|PubMed:28792876, ECO:0000269\|PubMed:8706755, ECO:0000269\|PubMed:9180257}.
Q9C0C7	AMBRA1	S1252	SIGNOR	Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)	Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:20921139, PubMed:23524951, PubMed:24587252, PubMed:32333458, PubMed:33854232, PubMed:33854235, PubMed:33854239). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins such as BECN1, CCND1, CCND2, CCND3, ELOC and ULK1 (PubMed:23524951, PubMed:33854232, PubMed:33854235, PubMed:33854239). Acts as an upstream master regulator of the transition from G1 to S cell phase: AMBRA1 specifically recognizes and binds phosphorylated cyclin-D (CCND1, CCND2 and CCND3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (PubMed:33854232, PubMed:33854235, PubMed:33854239). By controlling the transition from G1 to S phase and cyclin-D degradation, AMBRA1 acts as a tumor suppressor that promotes genomic integrity during DNA replication and counteracts developmental abnormalities and tumor growth (PubMed:33854232, PubMed:33854235, PubMed:33854239). AMBRA1 also regulates the cell cycle by promoting MYC dephosphorylation and degradation independently of the DCX(AMBRA1) complex: acts via interaction with the catalytic subunit of protein phosphatase 2A (PPP2CA), which enhances interaction between PPP2CA and MYC, leading to MYC dephosphorylation and degradation (PubMed:25438055, PubMed:25803737). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:25499913, PubMed:30166453). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (PubMed:21358617). In normal conditions, AMBRA1 is tethered to the cytoskeleton via interaction with dyneins DYNLL1 and DYNLL2 (PubMed:20921139). Upon autophagy induction, AMBRA1 is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (PubMed:20921139). The DCX(AMBRA1) complex mediates 'Lys-63'-linked ubiquitination of BECN1, increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). In collaboration with TRAF6, AMBRA1 mediates 'Lys-63'-linked ubiquitination of ULK1 following autophagy induction, promoting ULK1 stability and kinase activity (PubMed:23524951). Also activates ULK1 via interaction with TRIM32: TRIM32 stimulates ULK1 through unanchored 'Lys-63'-linked polyubiquitin chains (PubMed:31123703). Also acts as an activator of mitophagy via interaction with PRKN and LC3 proteins (MAP1LC3A, MAP1LC3B or MAP1LC3C); possibly by bringing damaged mitochondria onto autophagosomes (PubMed:21753002, PubMed:25215947). Also activates mitophagy by acting as a cofactor for HUWE1; acts by promoting HUWE1-mediated ubiquitination of MFN2 (PubMed:30217973). AMBRA1 is also involved in regulatory T-cells (Treg) differentiation by promoting FOXO3 dephosphorylation independently of the DCX(AMBRA1) complex: acts via interaction with PPP2CA, which enhances interaction between PPP2CA and FOXO3, leading to FOXO3 dephosphorylation and stabilization (PubMed:30513302). May act as a regulator of intracellular trafficking, regulating the localization of active PTK2/FAK and SRC (By similarity). Also involved in transcription regulation by acting as a scaffold for protein complexes at chromatin (By similarity). {ECO:0000250\|UniProtKB:A2AH22, ECO:0000269\|PubMed:20921139, ECO:0000269\|PubMed:21358617, ECO:0000269\|PubMed:21753002, ECO:0000269\|PubMed:23524951, ECO:0000269\|PubMed:24587252, ECO:0000269\|PubMed:25215947, ECO:0000269\|PubMed:25438055, ECO:0000269\|PubMed:25499913, ECO:0000269\|PubMed:25803737, ECO:0000269\|PubMed:30166453, ECO:0000269\|PubMed:30217973, ECO:0000269\|PubMed:30513302, ECO:0000269\|PubMed:31123703, ECO:0000269\|PubMed:32333458, ECO:0000269\|PubMed:33854232, ECO:0000269\|PubMed:33854235, ECO:0000269\|PubMed:33854239}.
Q99626	CDX2	S287	SIGNOR	Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)	Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250\|UniProtKB:P43241, ECO:0000250\|UniProtKB:Q04649, ECO:0000269\|PubMed:28473536}.
P51858	HDGF	S40	Sugiyama	Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)	[Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269\|PubMed:11751870, ECO:0000269\|PubMed:15491618, ECO:0000269\|PubMed:17974029, ECO:0000269\|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269\|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269\|PubMed:26845719}.
P24928	POLR2A	S1623	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1644	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1651	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1665	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1672	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1693	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1714	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1721	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1735	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1763	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1784	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1948	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
Q14432	PDE3A	S273	Sugiyama	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)	Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269\|PubMed:1315035, ECO:0000269\|PubMed:25961942, ECO:0000269\|PubMed:27975297, ECO:0000269\|PubMed:31420216, ECO:0000269\|PubMed:34707099, ECO:0000269\|PubMed:8155697, ECO:0000269\|PubMed:8695850}.
O14545	TRAFD1	S191	Sugiyama	TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)	Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16221674}.
Q96L34	MARK4	S557	Sugiyama	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)	Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250\|UniProtKB:Q8CIP4, ECO:0000269\|PubMed:14594945, ECO:0000269\|PubMed:15009667, ECO:0000269\|PubMed:23184942, ECO:0000269\|PubMed:23400999, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:25123532, ECO:0000269\|PubMed:28656979}.
Q9H093	NUAK2	S573	Sugiyama	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)	Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269\|PubMed:14575707, ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:15345718, ECO:0000269\|PubMed:19927127, ECO:0000269\|PubMed:32845958}.
Q9NQU5	PAK6	S146	Sugiyama	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269\|PubMed:14573606, ECO:0000269\|PubMed:20054820}.
Q8WWI1	LMO7	S1410	Sugiyama	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
A1A4S6	ARHGAP10	S591	ochoa	Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)	GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250\|UniProtKB:Q6Y5D8, ECO:0000269\|PubMed:11432776, ECO:0000269\|PubMed:32344433}.
A5PL33	KRBA1	S182	ochoa	Protein KRBA1	None
A5PL33	KRBA1	S355	ochoa	Protein KRBA1	None
A6NKF1	SAC3D1	S41	ochoa	SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1)	Involved in centrosome duplication and mitotic progression. {ECO:0000250}.
D6RIA3	C4orf54	S1707	ochoa	Uncharacterized protein C4orf54 (Familial obliterative portal venopathy)	None
E9PAV3	NACA	S949	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S972	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1018	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1042	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1066	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1112	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1135	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1623	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
H3BNR1	BORCS8-MEF2B	S205	ochoa	BORCS8-MEF2B readthrough	None
O14686	KMT2D	S2260	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O15015	ZNF646	S1442	ochoa	Zinc finger protein 646	May be involved in transcriptional regulation.
O15047	SETD1A	S1153	ochoa	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250\|UniProtKB:E9PYH6, ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:25561738, ECO:0000269\|PubMed:29937342, ECO:0000269\|PubMed:31197650, ECO:0000269\|PubMed:32346159, ECO:0000269\|PubMed:38003223}.
O15357	INPPL1	S1104	ochoa\|psp	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250\|UniProtKB:F1PNY0, ECO:0000250\|UniProtKB:Q6P549, ECO:0000250\|UniProtKB:Q9WVR3, ECO:0000269\|PubMed:11016922, ECO:0000269\|PubMed:11349134, ECO:0000269\|PubMed:11739414, ECO:0000269\|PubMed:12235291, ECO:0000269\|PubMed:12676785, ECO:0000269\|PubMed:12690104, ECO:0000269\|PubMed:15668240, ECO:0000269\|PubMed:15735664, ECO:0000269\|PubMed:16824732, ECO:0000269\|PubMed:17135240, ECO:0000269\|PubMed:21624956, ECO:0000269\|PubMed:23273569, ECO:0000269\|PubMed:9660833}.
O43521	BCL2L11	S69	psp	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269\|PubMed:11997495, ECO:0000269\|PubMed:15486195, ECO:0000269\|PubMed:15661735, ECO:0000269\|PubMed:9430630}.
O60240	PLIN1	S458	ochoa	Perilipin-1 (Lipid droplet-associated protein)	Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269\|PubMed:23399566}.
O60307	MAST3	S1215	ochoa	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	None
O60308	CEP104	S314	ochoa	Centrosomal protein of 104 kDa (Cep104)	Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269\|PubMed:23970417}.
O60336	MAPKBP1	S1314	ochoa	Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)	Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q6NS57, ECO:0000269\|PubMed:22700971}.
O75064	DENND4B	S1092	ochoa	DENN domain-containing protein 4B	Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269\|PubMed:20937701}.
O75161	NPHP4	S478	ochoa	Nephrocystin-4 (Nephroretinin)	Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250\|UniProtKB:B0DOB4, ECO:0000250\|UniProtKB:P59240, ECO:0000269\|PubMed:21498478, ECO:0000269\|PubMed:21555462, ECO:0000269\|PubMed:21565611, ECO:0000269\|PubMed:22654112, ECO:0000305\|PubMed:19755384}.
O75179	ANKRD17	S2045	ochoa\|psp	Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)	Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250\|UniProtKB:Q99NH0, ECO:0000269\|PubMed:17276651, ECO:0000269\|PubMed:19150984, ECO:0000269\|PubMed:22328336, ECO:0000269\|PubMed:23711367}.
P06401	PGR	S25	ochoa	Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)	The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269\|PubMed:10757795, ECO:0000269\|PubMed:1587864, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269\|PubMed:7969170, ECO:0000269\|PubMed:8180103, ECO:0000269\|PubMed:8264658, ECO:0000305, ECO:0000305\|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269\|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
P15408	FOSL2	S83	ochoa	Fos-related antigen 2 (FRA-2)	Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250\|UniProtKB:P47930, ECO:0000250\|UniProtKB:P51145}.
P23677	ITPKA	S95	ochoa	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)	Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269\|PubMed:12747803, ECO:0000269\|PubMed:15350214, ECO:0000269\|PubMed:1847047}.
P27987	ITPKB	S43	ochoa	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)	Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269\|PubMed:11846419, ECO:0000269\|PubMed:12747803, ECO:0000269\|PubMed:1654894}.
P29692	EEF1D	S133	ochoa\|psp	Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4)	[Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
P31350	RRM2	S20	ochoa\|psp	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
P36956	SREBF1	S117	ochoa\|psp	Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]	[Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250\|UniProtKB:Q9WTN3, ECO:0000269\|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250\|UniProtKB:Q9WTN3, ECO:0000269\|PubMed:12177166, ECO:0000269\|PubMed:32322062, ECO:0000269\|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250\|UniProtKB:Q9WTN3, ECO:0000269\|PubMed:12177166, ECO:0000269\|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250\|UniProtKB:Q9WTN3, ECO:0000269\|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305\|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305\|PubMed:7759101}.
P42694	HELZ	S1463	ochoa	Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein)	May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P46821	MAP1B	S1396	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P47974	ZFP36L2	S440	ochoa	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250\|UniProtKB:P23949, ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496, ECO:0000269\|PubMed:25106868, ECO:0000269\|PubMed:34611029}.
P48551	IFNAR2	S384	ochoa\|psp	Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)	Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:12105218, PubMed:28165510, PubMed:9121453). {ECO:0000269\|PubMed:10049744, ECO:0000269\|PubMed:10556041, ECO:0000269\|PubMed:11682488, ECO:0000269\|PubMed:12105218, ECO:0000269\|PubMed:17517919, ECO:0000269\|PubMed:21854986, ECO:0000269\|PubMed:26424569, ECO:0000269\|PubMed:28165510, ECO:0000269\|PubMed:32972995, ECO:0000269\|PubMed:7665574, ECO:0000269\|PubMed:7759950, ECO:0000269\|PubMed:8181059, ECO:0000269\|PubMed:8798579, ECO:0000269\|PubMed:8969169, ECO:0000269\|PubMed:9121453}.; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. {ECO:0000269\|PubMed:7759950}.
P51610	HCFC1	S1507	ochoa	Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]	Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250\|UniProtKB:D3ZN95, ECO:0000269\|PubMed:10629049, ECO:0000269\|PubMed:10675337, ECO:0000269\|PubMed:10779346, ECO:0000269\|PubMed:12244100, ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:14532282, ECO:0000269\|PubMed:15190068, ECO:0000269\|PubMed:16624878, ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:20200153, ECO:0000269\|PubMed:23629655, ECO:0000269\|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269\|PubMed:10629049, ECO:0000269\|PubMed:17578910}.
P54259	ATN1	S168	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P54259	ATN1	S661	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P54259	ATN1	S677	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P58012	FOXL2	S323	psp	Forkhead box protein L2	Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269\|PubMed:16153597, ECO:0000269\|PubMed:19010791, ECO:0000269\|PubMed:19429596, ECO:0000269\|PubMed:19744555}.
P98088	MUC5AC	S2239	ochoa	Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM)	Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269\|PubMed:14535999, ECO:0000303\|PubMed:14535999, ECO:0000303\|PubMed:14718370}.
Q00587	CDC42EP1	S113	ochoa	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)	Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269\|PubMed:10430899}.
Q00613	HSF1	S314	ochoa\|psp	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)	Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269\|PubMed:10359787, ECO:0000269\|PubMed:11447121, ECO:0000269\|PubMed:11583998, ECO:0000269\|PubMed:12659875, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:14707147, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:16278218, ECO:0000269\|PubMed:17897941, ECO:0000269\|PubMed:18451878, ECO:0000269\|PubMed:1871105, ECO:0000269\|PubMed:18794143, ECO:0000269\|PubMed:1986252, ECO:0000269\|PubMed:25963659, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:26727489, ECO:0000269\|PubMed:26754925, ECO:0000269\|PubMed:34723967, ECO:0000269\|PubMed:7623826, ECO:0000269\|PubMed:7760831, ECO:0000269\|PubMed:7935471, ECO:0000269\|PubMed:8455624, ECO:0000269\|PubMed:8940068, ECO:0000269\|PubMed:8946918, ECO:0000269\|PubMed:9121459, ECO:0000269\|PubMed:9341107, ECO:0000269\|PubMed:9499401, ECO:0000269\|PubMed:9535852, ECO:0000269\|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269\|PubMed:27189267}.
Q02040	AKAP17A	S499	ochoa	A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)	Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269\|PubMed:16982639, ECO:0000269\|PubMed:19840947}.
Q02080	MEF2B	S188	ochoa	Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2)	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Q03001	DST	S7416	ochoa	Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250\|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269\|PubMed:10428034, ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Q04323	UBXN1	S200	ochoa\|psp	UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)	Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Also prevents the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. {ECO:0000269\|PubMed:20351172, ECO:0000269\|PubMed:23545497, ECO:0000269\|PubMed:25681446, ECO:0000269\|PubMed:28152074}.
Q06190	PPP2R3A	S687	ochoa	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B)	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q07157	TJP1	S919	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07889	SOS1	S1193	psp	Son of sevenless homolog 1 (SOS-1)	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250\|UniProtKB:Q62245, ECO:0000269\|PubMed:17339331, ECO:0000269\|PubMed:8493579}.
Q12778	FOXO1	S416	psp	Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250\|UniProtKB:A4L7N3, ECO:0000250\|UniProtKB:G3V7R4, ECO:0000250\|UniProtKB:Q9R1E0, ECO:0000269\|PubMed:10358076, ECO:0000269\|PubMed:12228231, ECO:0000269\|PubMed:15220471, ECO:0000269\|PubMed:15890677, ECO:0000269\|PubMed:17024043, ECO:0000269\|PubMed:18356527, ECO:0000269\|PubMed:19221179, ECO:0000269\|PubMed:19483080, ECO:0000269\|PubMed:20543840, ECO:0000269\|PubMed:21245099, ECO:0000269\|PubMed:31063815}.
Q13136	PPFIA1	S708	ochoa	Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269\|PubMed:7796809}.
Q13319	CDK5R2	S173	psp	Cyclin-dependent kinase 5 activator 2 (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (p39) (p39I)	Activator of CDK5/TPKII.
Q13459	MYO9B	S2035	ochoa	Unconventional myosin-IXb (Unconventional myosin-9b)	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269\|PubMed:26529257, ECO:0000269\|PubMed:9490638}.
Q13573	SNW1	S232	ochoa	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269\|PubMed:10644367, ECO:0000269\|PubMed:11278756, ECO:0000269\|PubMed:11371506, ECO:0000269\|PubMed:11514567, ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12840015, ECO:0000269\|PubMed:14985122, ECO:0000269\|PubMed:15194481, ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:18794151, ECO:0000269\|PubMed:19818711, ECO:0000269\|PubMed:21245387, ECO:0000269\|PubMed:21460037, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:9632709, ECO:0000305\|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269\|PubMed:10644367}.
Q14CZ0	HAPSTR1	S167	ochoa	HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein)	Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269\|PubMed:33660365, ECO:0000269\|PubMed:35776542}.
Q15561	TEAD4	S205	ochoa	Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:19324877}.
Q15583	TGIF1	S95	ochoa	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)	Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
Q15744	CEBPE	S188	ochoa	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon)	Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). {ECO:0000269\|PubMed:10359588, ECO:0000269\|PubMed:26019275}.
Q2Q1W2	TRIM71	S187	ochoa	E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)	E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250\|UniProtKB:Q1PSW8, ECO:0000269\|PubMed:23125361, ECO:0000269\|PubMed:28431233, ECO:0000305\|PubMed:24239284}.
Q2QGD7	ZXDC	S34	ochoa	Zinc finger protein ZXDC (ZXD-like zinc finger protein)	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269\|PubMed:16600381, ECO:0000269\|PubMed:17493635, ECO:0000269\|PubMed:17696781}.
Q3KQU3	MAP7D1	S28	ochoa	MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)	Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250\|UniProtKB:A2AJI0}.
Q4KMQ1	TPRN	S274	ochoa	Taperin	Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250\|UniProtKB:A2AI08, ECO:0000269\|PubMed:23213405}.
Q52LD8	RFTN2	S453	ochoa	Raftlin-2 (Raft-linking protein 2)	Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250\|UniProtKB:Q8CHX7}.
Q5SW79	CEP170	S1522	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5SXM2	SNAPC4	S1224	ochoa	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit)	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269\|PubMed:12621023, ECO:0000269\|PubMed:9418884}.
Q5TCX8	MAP3K21	S115	ochoa	Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)	Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways. {ECO:0000269\|PubMed:21602844}.
Q5TGY3	AHDC1	S1476	ochoa	Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1)	Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269\|PubMed:35585237}.
Q5VWG9	TAF3	S809	ochoa	Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)	The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269\|PubMed:11438666, ECO:0000269\|PubMed:33795473}.
Q68CZ2	TNS3	S660	ochoa	Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250\|UniProtKB:Q5SSZ5, ECO:0000269\|PubMed:17643115, ECO:0000269\|PubMed:26166433, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:31905841, ECO:0000269\|PubMed:35687021, ECO:0000305}.
Q6J9G0	STYK1	S74	ochoa	Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)	Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}.
Q6NUN9	ZNF746	S613	ochoa\|psp	Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)	Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269\|PubMed:21376232, ECO:0000269\|PubMed:31856708}.
Q6P9H4	CNKSR3	S325	ochoa	Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein)	Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC). {ECO:0000269\|PubMed:22851176}.
Q6ZSS7	MFSD6	S755	ochoa	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)	None
Q6ZW31	SYDE1	S51	ochoa	Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)	GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269\|PubMed:27917469}.
Q86W56	PARG	S22	ochoa	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)	Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269\|PubMed:15450800, ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:23102699, ECO:0000269\|PubMed:23474714, ECO:0000269\|PubMed:23481255, ECO:0000269\|PubMed:24906880, ECO:0000269\|PubMed:27257257, ECO:0000269\|PubMed:33186521, ECO:0000269\|PubMed:34019811, ECO:0000269\|PubMed:34321462}.
Q86XF7	ZNF575	S49	ochoa	Zinc finger protein 575	May be involved in transcriptional regulation.
Q86Y01	DTX1	S279	ochoa	E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)	Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269\|PubMed:11564735, ECO:0000269\|PubMed:11869684, ECO:0000269\|PubMed:9590294}.
Q86YN6	PPARGC1B	S256	ochoa	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)	Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269\|PubMed:11854298, ECO:0000269\|PubMed:12678921, ECO:0000269\|PubMed:15546003, ECO:0000269\|PubMed:23836911}.
Q8IV63	VRK3	S115	psp	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IV63	VRK3	S122	ochoa\|psp	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IV63	VRK3	S129	ochoa\|psp	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IWD4	CCDC117	S53	ochoa	Coiled-coil domain-containing protein 117	Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B. {ECO:0000269\|PubMed:30742009}.
Q8IX07	ZFPM1	S901	ochoa	Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IY33	MICALL2	S249	ochoa	MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)	Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q3TN34}.
Q8IY33	MICALL2	T375	ochoa	MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)	Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q3TN34}.
Q8IY33	MICALL2	S658	ochoa	MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)	Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q3TN34}.
Q8IY33	MICALL2	S726	ochoa	MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)	Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q3TN34}.
Q8IY81	FTSJ3	S584	ochoa	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255\|HAMAP-Rule:MF_03163, ECO:0000269\|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269\|PubMed:30626973}.
Q8IYB3	SRRM1	S414	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8N6S5	ARL6IP6	S80	ochoa	ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1)	None
Q8NAX2	KDF1	S186	ochoa	Keratinocyte differentiation factor 1	Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250\|UniProtKB:A2A9F4}.
Q8NC74	RBBP8NL	S210	ochoa	RBBP8 N-terminal-like protein	None
Q8NC74	RBBP8NL	S251	ochoa	RBBP8 N-terminal-like protein	None
Q8NEZ4	KMT2C	S28	ochoa	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:24081332, ECO:0000269\|PubMed:25561738}.
Q8TBN0	RAB3IL1	S35	ochoa	Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)	Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269\|PubMed:20937701}.
Q8TE85	GRHL3	S493	ochoa	Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)	Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). {ECO:0000250\|UniProtKB:Q5FWH3, ECO:0000269\|PubMed:12549979, ECO:0000269\|PubMed:21081122, ECO:0000269\|PubMed:24360809, ECO:0000269\|PubMed:25347468}.
Q8TEK3	DOT1L	S826	ochoa	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269\|PubMed:12123582, ECO:0000269\|PubMed:12628190}.
Q8TF74	WIPF2	S235	ochoa	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269\|PubMed:11829459, ECO:0000269\|PubMed:12213210}.
Q8TF74	WIPF2	S303	ochoa	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269\|PubMed:11829459, ECO:0000269\|PubMed:12213210}.
Q8WXD9	CASKIN1	S819	ochoa	Caskin-1 (CASK-interacting protein 1)	May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WY91	THAP4	S299	ochoa	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269\|PubMed:30524950, ECO:0000269\|PubMed:32295384}.
Q92738	USP6NL	S784	ochoa	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269\|PubMed:11099046, ECO:0000269\|PubMed:17562788, ECO:0000269\|PubMed:17684057}.
Q92738	USP6NL	S791	ochoa	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269\|PubMed:11099046, ECO:0000269\|PubMed:17562788, ECO:0000269\|PubMed:17684057}.
Q92918	MAP4K1	S447	ochoa	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)	Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250\|UniProtKB:P70218, ECO:0000269\|PubMed:24362026, ECO:0000269\|PubMed:26437443, ECO:0000269\|PubMed:8824585}.
Q969V6	MRTFA	S785	ochoa	Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)	Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250\|UniProtKB:Q8K4J6, ECO:0000269\|PubMed:26224645}.
Q969V6	MRTFA	S792	ochoa	Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)	Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250\|UniProtKB:Q8K4J6, ECO:0000269\|PubMed:26224645}.
Q96HA1	POM121	S188	ochoa	Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)	Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269\|PubMed:17900573}.
Q96HR8	NAF1	S98	ochoa	H/ACA ribonucleoprotein complex non-core subunit NAF1 (hNAF1)	RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. {ECO:0000269\|PubMed:16618814}.
Q96JM3	CHAMP1	S507	ochoa	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269\|PubMed:21063390}.
Q96L14	CEP170P1	S231	ochoa	Cep170-like protein (CEP170 pseudogene 1)	None
Q96QC0	PPP1R10	S545	ochoa	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99)	Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250\|UniProtKB:Q80W00, ECO:0000269\|PubMed:18360108, ECO:0000269\|PubMed:30158517, ECO:0000269\|PubMed:31677974, ECO:0000269\|PubMed:33264625, ECO:0000269\|PubMed:39603239, ECO:0000269\|PubMed:39603240, ECO:0000269\|PubMed:9450550}.
Q96RY5	CRAMP1	S75	ochoa	Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein)	None
Q9BQG0	MYBBP1A	S1241	ochoa	Myb-binding protein 1A	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250\|UniProtKB:Q7TPV4, ECO:0000269\|PubMed:29065309}.
Q9BQG0	MYBBP1A	S1248	ochoa	Myb-binding protein 1A	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250\|UniProtKB:Q7TPV4, ECO:0000269\|PubMed:29065309}.
Q9BT49	THAP7	S162	ochoa	THAP domain-containing protein 7	Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000269\|PubMed:15561719}.
Q9BVG8	KIFC3	S41	ochoa	Kinesin-like protein KIFC3	Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269\|PubMed:19041755}.
Q9BZF1	OSBPL8	S68	ochoa	Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)	Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:17991739, ECO:0000269\|PubMed:21698267, ECO:0000269\|PubMed:26206935}.
Q9C0C4	SEMA4C	S772	ochoa	Semaphorin-4C	Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269\|PubMed:17498836}.
Q9H3T3	SEMA6B	S794	ochoa	Semaphorin-6B (Semaphorin-Z) (Sema Z)	Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250\|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269\|PubMed:32302524, ECO:0000269\|PubMed:32589945}.
Q9H7L9	SUDS3	S248	ochoa	Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)	Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269\|PubMed:12724404, ECO:0000269\|PubMed:21239494}.
Q9H987	SYNPO2L	S945	ochoa	Synaptopodin 2-like protein	Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}.
Q9NQC3	RTN4	S152	ochoa	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269\|PubMed:24262037, ECO:0000269\|PubMed:25612671, ECO:0000269\|PubMed:26906412, ECO:0000269\|PubMed:27619977, ECO:0000269\|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:10667797, ECO:0000269\|PubMed:11201742, ECO:0000269\|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:11126360, ECO:0000269\|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:16965550}.
Q9NRA0	SPHK2	S484	ochoa	Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)	Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250\|UniProtKB:Q9JIA7, ECO:0000269\|PubMed:12954646, ECO:0000269\|PubMed:16103110, ECO:0000269\|PubMed:16118219, ECO:0000269\|PubMed:19168031, ECO:0000269\|PubMed:19729656, ECO:0000269\|PubMed:20959514}.
Q9NRR6	INPP5E	S38	ochoa	Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity). {ECO:0000250\|UniProtKB:Q9JII1, ECO:0000269\|PubMed:10764818}.
Q9NYB9	ABI2	S216	ochoa	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)	Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250\|UniProtKB:P62484, ECO:0000269\|PubMed:10498863, ECO:0000269\|PubMed:15572692, ECO:0000269\|PubMed:21107423, ECO:0000269\|PubMed:7590236, ECO:0000269\|PubMed:8649853}.
Q9P1Y5	CAMSAP3	S554	ochoa	Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250\|UniProtKB:Q80VC9, ECO:0000269\|PubMed:19041755, ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:26715742, ECO:0000269\|PubMed:27693509, ECO:0000269\|PubMed:27802168, ECO:0000269\|PubMed:28089391, ECO:0000269\|PubMed:28386021}.
Q9P1Y5	CAMSAP3	S814	ochoa	Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250\|UniProtKB:Q80VC9, ECO:0000269\|PubMed:19041755, ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:26715742, ECO:0000269\|PubMed:27693509, ECO:0000269\|PubMed:27802168, ECO:0000269\|PubMed:28089391, ECO:0000269\|PubMed:28386021}.
Q9P266	JCAD	S400	ochoa	Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD)	None
Q9ULC8	ZDHHC8	S682	ochoa	Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250\|UniProtKB:Q5Y5T5, ECO:0000305\|PubMed:19556522, ECO:0000305\|PubMed:23034182, ECO:0000305\|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269\|PubMed:34599882}.
Q9UN79	SOX13	S268	ochoa	Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)	Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250\|UniProtKB:Q04891, ECO:0000269\|PubMed:10871192, ECO:0000269\|PubMed:20028982}.
Q9UPS6	SETD1B	S1275	ochoa	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250\|UniProtKB:Q8CFT2, ECO:0000269\|PubMed:17355966, ECO:0000269\|PubMed:25561738}.
Q9Y4B5	MTCL1	S263	ochoa	Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)	Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269\|PubMed:23902687, ECO:0000269\|PubMed:33587225}.
Q9Y4F5	CEP170B	S986	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y5W3	KLF2	S177	ochoa\|psp	Krueppel-like factor 2 (Lung krueppel-like factor)	Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). {ECO:0000269\|PubMed:21063504, ECO:0000269\|PubMed:28167758}.
P35658	NUP214	S678	Sugiyama	Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)	Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269\|PubMed:31178128, ECO:0000269\|PubMed:9049309, ECO:0000303\|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269\|PubMed:25410864}.
Q92558	WASF1	S397	iPTMNet	Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250\|UniProtKB:Q8R5H6, ECO:0000269\|PubMed:29961568, ECO:0000269\|PubMed:9889097}.

Download

reactome_id	name	p	-log10_p
R-HSA-3214841	PKMTs methylate histone lysines	0.000001	5.852
R-HSA-212165	Epigenetic regulation of gene expression	0.000002	5.683
R-HSA-3247509	Chromatin modifying enzymes	0.000043	4.364
R-HSA-4839726	Chromatin organization	0.000093	4.030
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	0.000134	3.874
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.000172	3.764
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.000210	3.678
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.000429	3.368
R-HSA-210745	Regulation of gene expression in beta cells	0.000512	3.291
R-HSA-186712	Regulation of beta-cell development	0.000687	3.163
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.001287	2.890
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.001519	2.818
R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	0.002135	2.671
R-HSA-74160	Gene expression (Transcription)	0.001931	2.714
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.002180	2.662
R-HSA-162582	Signal Transduction	0.002084	2.681
R-HSA-9700206	Signaling by ALK in cancer	0.002180	2.662
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.002388	2.622
R-HSA-112412	SOS-mediated signalling	0.002920	2.535
R-HSA-9031528	NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo...	0.002920	2.535
R-HSA-2028269	Signaling by Hippo	0.003597	2.444
R-HSA-9831926	Nephron development	0.004204	2.376
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	0.004204	2.376
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.004594	2.338
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	0.005291	2.276
R-HSA-74749	Signal attenuation	0.006033	2.219
R-HSA-4839744	Signaling by APC mutants	0.007383	2.132
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.007383	2.132
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.007383	2.132
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.007383	2.132
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.007079	2.150
R-HSA-5339716	Signaling by GSK3beta mutants	0.008898	2.051
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.010582	1.975
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.010582	1.975
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.010582	1.975
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.010582	1.975
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.010582	1.975
R-HSA-9843745	Adipogenesis	0.009190	2.037
R-HSA-4839735	Signaling by AXIN mutants	0.008898	2.051
R-HSA-4839748	Signaling by AMER1 mutants	0.008898	2.051
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.008362	2.078
R-HSA-73887	Death Receptor Signaling	0.009951	2.002
R-HSA-201556	Signaling by ALK	0.009988	2.001
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.009531	2.021
R-HSA-8878159	Transcriptional regulation by RUNX3	0.011859	1.926
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.011859	1.926
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	0.012505	1.903
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	0.012438	1.905
R-HSA-9796292	Formation of axial mesoderm	0.012438	1.905
R-HSA-193704	p75 NTR receptor-mediated signalling	0.013105	1.883
R-HSA-9027284	Erythropoietin activates RAS	0.016675	1.778
R-HSA-196299	Beta-catenin phosphorylation cascade	0.016675	1.778
R-HSA-446353	Cell-extracellular matrix interactions	0.016675	1.778
R-HSA-74713	IRS activation	0.016714	1.777
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.018151	1.741
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.018151	1.741
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.018151	1.741
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	0.019083	1.719
R-HSA-9758920	Formation of lateral plate mesoderm	0.021436	1.669
R-HSA-9675151	Disorders of Developmental Biology	0.021623	1.665
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.021436	1.669
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.024657	1.608
R-HSA-427413	NoRC negatively regulates rRNA expression	0.024713	1.607
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.027499	1.561
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.026643	1.574
R-HSA-9614657	FOXO-mediated transcription of cell death genes	0.027287	1.564
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.027446	1.562
R-HSA-1236394	Signaling by ERBB4	0.028885	1.539
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.032302	1.491
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.031117	1.507
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.033494	1.475
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.032185	1.492
R-HSA-3214815	HDACs deacetylate histones	0.033053	1.481
R-HSA-193648	NRAGE signals death through JNK	0.034985	1.456
R-HSA-383280	Nuclear Receptor transcription pathway	0.035131	1.454
R-HSA-5689896	Ovarian tumor domain proteases	0.035926	1.445
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.035926	1.445
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	0.054243	1.266
R-HSA-9763198	Impaired BRCA2 binding to SEM1 (DSS1)	0.054243	1.266
R-HSA-9709275	Impaired BRCA2 translocation to the nucleus	0.054243	1.266
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.080253	1.096
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E...	0.080253	1.096
R-HSA-5602636	IKBKB deficiency causes SCID	0.080253	1.096
R-HSA-3359471	Defective MMAB causes MMA, cblB type	0.080253	1.096
R-HSA-5674404	PTEN Loss of Function in Cancer	0.080253	1.096
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.105550	0.977
R-HSA-3249367	STAT6-mediated induction of chemokines	0.130152	0.886
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.130152	0.886
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	0.130152	0.886
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	0.130152	0.886
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.154079	0.812
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.154079	0.812
R-HSA-8875555	MET activates RAP1 and RAC1	0.051719	1.286
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	0.177349	0.751
R-HSA-203754	NOSIP mediated eNOS trafficking	0.177349	0.751
R-HSA-9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	0.066435	1.178
R-HSA-202670	ERKs are inactivated	0.066435	1.178
R-HSA-8985586	SLIT2:ROBO1 increases RHOA activity	0.199981	0.699
R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	0.199981	0.699
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.082346	1.084
R-HSA-9027283	Erythropoietin activates STAT5	0.221991	0.654
R-HSA-350054	Notch-HLH transcription pathway	0.044543	1.351
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.099278	1.003
R-HSA-176412	Phosphorylation of the APC/C	0.108078	0.966
R-HSA-8948747	Regulation of PTEN localization	0.243397	0.614
R-HSA-9031525	NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake	0.243397	0.614
R-HSA-8875656	MET receptor recycling	0.264215	0.578
R-HSA-9006335	Signaling by Erythropoietin	0.075723	1.121
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.080793	1.093
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.145085	0.838
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.086007	1.065
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.086007	1.065
R-HSA-1855170	IPs transport between nucleus and cytosol	0.096846	1.014
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.096846	1.014
R-HSA-9027277	Erythropoietin activates Phospholipase C gamma (PLCG)	0.304153	0.517
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.102464	0.989
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.184228	0.735
R-HSA-163765	ChREBP activates metabolic gene expression	0.323303	0.490
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.194243	0.712
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.194243	0.712
R-HSA-112382	Formation of RNA Pol II elongation complex	0.088826	1.051
R-HSA-429947	Deadenylation of mRNA	0.204325	0.690
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.341927	0.466
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	0.341927	0.466
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.092949	1.032
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.138669	0.858
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.145079	0.838
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.360040	0.444
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.360040	0.444
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	0.360040	0.444
R-HSA-179812	GRB2 events in EGFR signaling	0.360040	0.444
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.234864	0.629
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.234864	0.629
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.245108	0.611
R-HSA-167287	HIV elongation arrest and recovery	0.245108	0.611
R-HSA-113418	Formation of the Early Elongation Complex	0.245108	0.611
R-HSA-167290	Pausing and recovery of HIV elongation	0.245108	0.611
R-HSA-9861559	PDH complex synthesizes acetyl-CoA from PYR	0.377655	0.423
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.394787	0.404
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.124985	0.903
R-HSA-141424	Amplification of signal from the kinetochores	0.124985	0.903
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.191899	0.717
R-HSA-3371511	HSF1 activation	0.337096	0.472
R-HSA-1989781	PPARA activates gene expression	0.114483	0.941
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.244155	0.612
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	0.295152	0.530
R-HSA-3371568	Attenuation phase	0.377053	0.424
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.377053	0.424
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.377053	0.424
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.317815	0.498
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.396661	0.402
R-HSA-167161	HIV Transcription Initiation	0.396661	0.402
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.396661	0.402
R-HSA-8854518	AURKA Activation by TPX2	0.340502	0.468
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.135742	0.867
R-HSA-72163	mRNA Splicing - Major Pathway	0.246709	0.608
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.393107	0.405
R-HSA-72172	mRNA Splicing	0.289738	0.538
R-HSA-167172	Transcription of the HIV genome	0.355601	0.449
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.059481	1.226
R-HSA-167169	HIV Transcription Elongation	0.377053	0.424
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.080793	1.093
R-HSA-72086	mRNA Capping	0.255368	0.593
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.265636	0.576
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.128999	0.889
R-HSA-1234174	Cellular response to hypoxia	0.332942	0.478
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.164447	0.784
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.224646	0.649
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.299105	0.524
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.377053	0.424
R-HSA-8943724	Regulation of PTEN gene transcription	0.043401	1.363
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.049724	1.303
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	0.228188	0.642
R-HSA-198203	PI3K/AKT activation	0.051719	1.286
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.199981	0.699
R-HSA-389513	Co-inhibition by CTLA4	0.154707	0.810
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.125406	0.902
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.367150	0.435
R-HSA-3371556	Cellular response to heat stress	0.325012	0.488
R-HSA-9614085	FOXO-mediated transcription	0.090139	1.045
R-HSA-191650	Regulation of gap junction activity	0.154079	0.812
R-HSA-428540	Activation of RAC1	0.066435	1.178
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	0.108208	0.966
R-HSA-6807070	PTEN Regulation	0.271107	0.567
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.077008	1.113
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.225046	0.648
R-HSA-5619507	Activation of HOX genes during differentiation	0.225046	0.648
R-HSA-74158	RNA Polymerase III Transcription	0.120057	0.921
R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.074252	1.129
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.072316	1.141
R-HSA-69618	Mitotic Spindle Checkpoint	0.093092	1.031
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.335889	0.474
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.081663	1.088
R-HSA-8851805	MET activates RAS signaling	0.074252	1.129
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.138669	0.858
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.114263	0.942
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.120057	0.921
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.325012	0.488
R-HSA-8849473	PTK6 Expression	0.243397	0.614
R-HSA-2025928	Calcineurin activates NFAT	0.284462	0.546
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.052788	1.277
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.265636	0.576
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	0.280098	0.553
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	0.406358	0.391
R-HSA-72613	Eukaryotic Translation Initiation	0.298015	0.526
R-HSA-72737	Cap-dependent Translation Initiation	0.298015	0.526
R-HSA-2424491	DAP12 signaling	0.265636	0.576
R-HSA-9842860	Regulation of endogenous retroelements	0.099154	1.004
R-HSA-73864	RNA Polymerase I Transcription	0.220508	0.657
R-HSA-68877	Mitotic Prometaphase	0.242904	0.615
R-HSA-2467813	Separation of Sister Chromatids	0.397218	0.401
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.204325	0.690
R-HSA-162599	Late Phase of HIV Life Cycle	0.290010	0.538
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.370655	0.431
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.221991	0.654
R-HSA-9614399	Regulation of localization of FOXO transcription factors	0.323303	0.490
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.234864	0.629
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	0.394787	0.404
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.306629	0.513
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.208926	0.680
R-HSA-74751	Insulin receptor signalling cascade	0.325378	0.488
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.255368	0.593
R-HSA-2428928	IRS-related events triggered by IGF1R	0.302698	0.519
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.046762	1.330
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	0.145079	0.838
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	0.145079	0.838
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.210149	0.677
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.295152	0.530
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.295152	0.530
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.295152	0.530
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.295152	0.530
R-HSA-1257604	PIP3 activates AKT signaling	0.106876	0.971
R-HSA-1980143	Signaling by NOTCH1	0.088234	1.054
R-HSA-4791275	Signaling by WNT in cancer	0.091359	1.039
R-HSA-8943723	Regulation of PTEN mRNA translation	0.194243	0.712
R-HSA-2428924	IGF1R signaling cascade	0.325378	0.488
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.105550	0.977
R-HSA-8875513	MET interacts with TNS proteins	0.130152	0.886
R-HSA-9022538	Loss of MECP2 binding ability to 5mC-DNA	0.130152	0.886
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	0.154079	0.812
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.066435	1.178
R-HSA-209560	NF-kB is activated and signals survival	0.066435	1.178
R-HSA-5603029	IkBA variant leads to EDA-ID	0.199981	0.699
R-HSA-176417	Phosphorylation of Emi1	0.199981	0.699
R-HSA-114516	Disinhibition of SNARE formation	0.243397	0.614
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.264215	0.578
R-HSA-446107	Type I hemidesmosome assembly	0.264215	0.578
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.135596	0.868
R-HSA-428543	Inactivation of CDC42 and RAC1	0.284462	0.546
R-HSA-9034864	Activated NTRK3 signals through RAS	0.323303	0.490
R-HSA-192814	vRNA Synthesis	0.323303	0.490
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.126154	0.899
R-HSA-8875878	MET promotes cell motility	0.132359	0.878
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.341927	0.466
R-HSA-9026519	Activated NTRK2 signals through RAS	0.341927	0.466
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.214463	0.669
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.145079	0.838
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.360040	0.444
R-HSA-429914	Deadenylation-dependent mRNA decay	0.119508	0.923
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.377655	0.423
R-HSA-168325	Viral Messenger RNA Synthesis	0.129016	0.889
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.185386	0.732
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	0.316821	0.499
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.156061	0.807
R-HSA-9664417	Leishmania phagocytosis	0.152620	0.816
R-HSA-9664407	Parasite infection	0.152620	0.816
R-HSA-9664422	FCGR3A-mediated phagocytosis	0.152620	0.816
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.332942	0.478
R-HSA-156711	Polo-like kinase mediated events	0.135596	0.868
R-HSA-9646399	Aggrephagy	0.377053	0.424
R-HSA-9664873	Pexophagy	0.051719	1.286
R-HSA-193639	p75NTR signals via NF-kB	0.099278	1.003
R-HSA-2980766	Nuclear Envelope Breakdown	0.036985	1.432
R-HSA-9909396	Circadian clock	0.234318	0.630
R-HSA-209543	p75NTR recruits signalling complexes	0.074252	1.129
R-HSA-112399	IRS-mediated signalling	0.272598	0.564
R-HSA-9006925	Intracellular signaling by second messengers	0.215296	0.667
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.316821	0.499
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.211630	0.674
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	0.370655	0.431
R-HSA-1834941	STING mediated induction of host immune responses	0.145085	0.838
R-HSA-5357905	Regulation of TNFR1 signaling	0.066041	1.180
R-HSA-162587	HIV Life Cycle	0.362793	0.440
R-HSA-9842663	Signaling by LTK	0.074252	1.129
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.074252	1.129
R-HSA-9005895	Pervasive developmental disorders	0.074252	1.129
R-HSA-9697154	Disorders of Nervous System Development	0.074252	1.129
R-HSA-9603381	Activated NTRK3 signals through PI3K	0.243397	0.614
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.264215	0.578
R-HSA-9930044	Nuclear RNA decay	0.096846	1.014
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.102464	0.989
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.184228	0.735
R-HSA-2428933	SHC-related events triggered by IGF1R	0.360040	0.444
R-HSA-5578749	Transcriptional regulation by small RNAs	0.186324	0.730
R-HSA-9707616	Heme signaling	0.310254	0.508
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.265636	0.576
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	0.066027	1.180
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.082346	1.084
R-HSA-193697	p75NTR regulates axonogenesis	0.284462	0.546
R-HSA-166208	mTORC1-mediated signalling	0.184228	0.735
R-HSA-75893	TNF signaling	0.105848	0.975
R-HSA-68875	Mitotic Prophase	0.319588	0.495
R-HSA-8953854	Metabolism of RNA	0.282524	0.549
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.186324	0.730
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.105819	0.975
R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.221991	0.654
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.117076	0.932
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.164447	0.784
R-HSA-2179392	EGFR Transactivation by Gastrin	0.304153	0.517
R-HSA-1483226	Synthesis of PI	0.323303	0.490
R-HSA-912526	Interleukin receptor SHC signaling	0.194243	0.712
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.038556	1.414
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.204325	0.690
R-HSA-9617629	Regulation of FOXO transcriptional activity by acetylation	0.360040	0.444
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.245108	0.611
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.394787	0.404
R-HSA-194441	Metabolism of non-coding RNA	0.287618	0.541
R-HSA-191859	snRNP Assembly	0.287618	0.541
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.139563	0.855
R-HSA-9006931	Signaling by Nuclear Receptors	0.275068	0.561
R-HSA-5655302	Signaling by FGFR1 in disease	0.396661	0.402
R-HSA-186763	Downstream signal transduction	0.086007	1.065
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.295152	0.530
R-HSA-69275	G2/M Transition	0.347894	0.459
R-HSA-1592230	Mitochondrial biogenesis	0.303388	0.518
R-HSA-453274	Mitotic G2-G2/M phases	0.356855	0.448
R-HSA-1251985	Nuclear signaling by ERBB4	0.043901	1.358
R-HSA-6806834	Signaling by MET	0.102172	0.991
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.066027	1.180
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.284462	0.546
R-HSA-198753	ERK/MAPK targets	0.164447	0.784
R-HSA-180746	Nuclear import of Rev protein	0.108208	0.966
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.360040	0.444
R-HSA-205043	NRIF signals cell death from the nucleus	0.394787	0.404
R-HSA-9663891	Selective autophagy	0.286736	0.543
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.294859	0.530
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.287618	0.541
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.224646	0.649
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	0.108078	0.966
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	0.264215	0.578
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.284462	0.546
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.284462	0.546
R-HSA-9022702	MECP2 regulates transcription of neuronal ligands	0.304153	0.517
R-HSA-9671555	Signaling by PDGFR in disease	0.174292	0.759
R-HSA-177243	Interactions of Rev with host cellular proteins	0.145079	0.838
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.145079	0.838
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.151584	0.819
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.224646	0.649
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	0.360040	0.444
R-HSA-937039	IRAK1 recruits IKK complex	0.360040	0.444
R-HSA-8866427	VLDLR internalisation and degradation	0.360040	0.444
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.360040	0.444
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.394787	0.404
R-HSA-8878171	Transcriptional regulation by RUNX1	0.045924	1.338
R-HSA-8941326	RUNX2 regulates bone development	0.337096	0.472
R-HSA-211000	Gene Silencing by RNA	0.240246	0.619
R-HSA-73857	RNA Polymerase II Transcription	0.054327	1.265
R-HSA-177929	Signaling by EGFR	0.265120	0.577
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.268332	0.571
R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.061408	1.212
R-HSA-170968	Frs2-mediated activation	0.377655	0.423
R-HSA-5693606	DNA Double Strand Break Response	0.348056	0.458
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.138828	0.858
R-HSA-8848021	Signaling by PTK6	0.138828	0.858
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	0.326979	0.485
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.186651	0.729
R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.174292	0.759
R-HSA-212436	Generic Transcription Pathway	0.113944	0.943
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	0.199981	0.699
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.040744	1.390
R-HSA-111458	Formation of apoptosome	0.304153	0.517
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.323303	0.490
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.132359	0.878
R-HSA-8949664	Processing of SMDT1	0.377655	0.423
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.192372	0.716
R-HSA-416482	G alpha (12/13) signalling events	0.220508	0.657
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.370655	0.431
R-HSA-3214847	HATs acetylate histones	0.367855	0.434
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.310254	0.508
R-HSA-8953750	Transcriptional Regulation by E2F6	0.138669	0.858
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.224646	0.649
R-HSA-1226099	Signaling by FGFR in disease	0.400547	0.397
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.154678	0.811
R-HSA-9006936	Signaling by TGFB family members	0.064640	1.190
R-HSA-1483249	Inositol phosphate metabolism	0.061326	1.212
R-HSA-5688426	Deubiquitination	0.241747	0.617
R-HSA-9860276	SLC15A4:TASL-dependent IRF5 activation	0.199981	0.699
R-HSA-5578768	Physiological factors	0.090694	1.042
R-HSA-388844	Receptor-type tyrosine-protein phosphatases	0.108078	0.966
R-HSA-9627069	Regulation of the apoptosome activity	0.304153	0.517
R-HSA-8853659	RET signaling	0.120057	0.921
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.341927	0.466
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.138669	0.858
R-HSA-5673000	RAF activation	0.316821	0.499
R-HSA-1266738	Developmental Biology	0.049892	1.302
R-HSA-194138	Signaling by VEGF	0.199262	0.701
R-HSA-186797	Signaling by PDGF	0.310254	0.508
R-HSA-187687	Signalling to ERKs	0.326979	0.485
R-HSA-8986944	Transcriptional Regulation by MECP2	0.063499	1.197
R-HSA-168255	Influenza Infection	0.316770	0.499
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.290010	0.538
R-HSA-9733709	Cardiogenesis	0.296407	0.528
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.243397	0.614
R-HSA-9762293	Regulation of CDH11 gene transcription	0.284462	0.546
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	0.304153	0.517
R-HSA-9022692	Regulation of MECP2 expression and activity	0.296407	0.528
R-HSA-6784531	tRNA processing in the nucleus	0.310254	0.508
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.308775	0.510
R-HSA-388841	Regulation of T cell activation by CD28 family	0.245064	0.611
R-HSA-201681	TCF dependent signaling in response to WNT	0.206035	0.686
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.151584	0.819
R-HSA-9679191	Potential therapeutics for SARS	0.192329	0.716
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.049588	1.305
R-HSA-166520	Signaling by NTRKs	0.096469	1.016
R-HSA-5655291	Signaling by FGFR4 in disease	0.394787	0.404
R-HSA-70171	Glycolysis	0.374117	0.427
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.243397	0.614
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.255368	0.593
R-HSA-1433559	Regulation of KIT signaling	0.394787	0.404
R-HSA-450294	MAP kinase activation	0.302698	0.519
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.168345	0.774
R-HSA-9856651	MITF-M-dependent gene expression	0.101440	0.994
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.310254	0.508
R-HSA-9819196	Zygotic genome activation (ZGA)	0.164447	0.784
R-HSA-389948	Co-inhibition by PD-1	0.269930	0.569
R-HSA-448424	Interleukin-17 signaling	0.370655	0.431
R-HSA-432142	Platelet sensitization by LDL	0.135596	0.868
R-HSA-430116	GP1b-IX-V activation signalling	0.284462	0.546
R-HSA-8963896	HDL assembly	0.394787	0.404
R-HSA-9833110	RSV-host interactions	0.405324	0.392
R-HSA-2586552	Signaling by Leptin	0.051719	1.286
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.164863	0.783
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.186324	0.730
R-HSA-165159	MTOR signalling	0.406358	0.391
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	0.264215	0.578
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.284462	0.546
R-HSA-9730414	MITF-M-regulated melanocyte development	0.326225	0.486
R-HSA-9758941	Gastrulation	0.188557	0.725
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.207713	0.683
R-HSA-9694548	Maturation of spike protein	0.386891	0.412
R-HSA-9830369	Kidney development	0.159301	0.798
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.091359	1.039
R-HSA-109581	Apoptosis	0.387380	0.412
R-HSA-449147	Signaling by Interleukins	0.348361	0.458
R-HSA-8853884	Transcriptional Regulation by VENTX	0.386891	0.412
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.306629	0.513
R-HSA-9008059	Interleukin-37 signaling	0.265636	0.576
R-HSA-69205	G1/S-Specific Transcription	0.337096	0.472
R-HSA-9607240	FLT3 Signaling	0.151584	0.819
R-HSA-1483255	PI Metabolism	0.210149	0.677
R-HSA-8983711	OAS antiviral response	0.360040	0.444
R-HSA-8983432	Interleukin-15 signaling	0.360040	0.444
R-HSA-5675221	Negative regulation of MAPK pathway	0.396661	0.402
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	0.296407	0.528
R-HSA-75153	Apoptotic execution phase	0.192372	0.716
R-HSA-451927	Interleukin-2 family signaling	0.377053	0.424
R-HSA-8863678	Neurodegenerative Diseases	0.204325	0.690
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	0.204325	0.690
R-HSA-381038	XBP1(S) activates chaperone genes	0.274444	0.562
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.234864	0.629
R-HSA-1266695	Interleukin-7 signaling	0.214463	0.669
R-HSA-381070	IRE1alpha activates chaperones	0.311535	0.506
R-HSA-982772	Growth hormone receptor signaling	0.194243	0.712
R-HSA-380287	Centrosome maturation	0.407962	0.389
R-HSA-1169408	ISG15 antiviral mechanism	0.407962	0.389
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.411448	0.386
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.411448	0.386
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.411448	0.386
R-HSA-180336	SHC1 events in EGFR signaling	0.411448	0.386
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	0.411448	0.386
R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.411448	0.386
R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	0.411448	0.386
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.411448	0.386
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.411448	0.386
R-HSA-5696398	Nucleotide Excision Repair	0.411534	0.386
R-HSA-5689603	UCH proteinases	0.415348	0.382
R-HSA-73776	RNA Polymerase II Promoter Escape	0.415979	0.381
R-HSA-9018519	Estrogen-dependent gene expression	0.423247	0.373
R-HSA-2172127	DAP12 interactions	0.425522	0.371
R-HSA-5083636	Defective GALNT12 causes CRCS1	0.427651	0.369
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	0.427651	0.369
R-HSA-5083625	Defective GALNT3 causes HFTC	0.427651	0.369
R-HSA-9758274	Regulation of NF-kappa B signaling	0.427651	0.369
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.427651	0.369
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.427651	0.369
R-HSA-9945266	Differentiation of T cells	0.427651	0.369
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	0.427651	0.369
R-HSA-9634600	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	0.427651	0.369
R-HSA-169893	Prolonged ERK activation events	0.427651	0.369
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.430077	0.366
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.430077	0.366
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.434982	0.362
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.437323	0.359
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.443409	0.353
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	0.443409	0.353
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.443409	0.353
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.443409	0.353
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.443409	0.353
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	0.443409	0.353
R-HSA-9690406	Transcriptional regulation of testis differentiation	0.443409	0.353
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.444358	0.352
R-HSA-9833482	PKR-mediated signaling	0.444579	0.352
R-HSA-2262752	Cellular responses to stress	0.448544	0.348
R-HSA-1632852	Macroautophagy	0.450256	0.347
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.454551	0.342
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.454551	0.342
R-HSA-5083632	Defective C1GALT1C1 causes TNPS	0.458735	0.338
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.458735	0.338
R-HSA-1963642	PI3K events in ERBB2 signaling	0.458735	0.338
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.458735	0.338
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.458735	0.338
R-HSA-9909505	Modulation of host responses by IFN-stimulated genes	0.458735	0.338
R-HSA-389356	Co-stimulation by CD28	0.462847	0.335
R-HSA-9031628	NGF-stimulated transcription	0.462847	0.335
R-HSA-9707564	Cytoprotection by HMOX1	0.466120	0.332
R-HSA-8856828	Clathrin-mediated endocytosis	0.466305	0.331
R-HSA-69278	Cell Cycle, Mitotic	0.471101	0.327
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.471955	0.326
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.473218	0.325
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.473639	0.325
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.473639	0.325
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.473639	0.325
R-HSA-210993	Tie2 Signaling	0.473639	0.325
R-HSA-180292	GAB1 signalosome	0.473639	0.325
R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.473639	0.325
R-HSA-111471	Apoptotic factor-mediated response	0.473639	0.325
R-HSA-1852241	Organelle biogenesis and maintenance	0.476267	0.322
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.478671	0.320
R-HSA-2559583	Cellular Senescence	0.479994	0.319
R-HSA-109704	PI3K Cascade	0.480969	0.318
R-HSA-5655253	Signaling by FGFR2 in disease	0.480969	0.318
R-HSA-68882	Mitotic Anaphase	0.486765	0.313
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.488133	0.311
R-HSA-9709603	Impaired BRCA2 binding to PALB2	0.488133	0.311
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.488133	0.311
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.488133	0.311
R-HSA-912631	Regulation of signaling by CBL	0.488133	0.311
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.488133	0.311
R-HSA-392517	Rap1 signalling	0.488133	0.311
R-HSA-3371571	HSF1-dependent transactivation	0.489889	0.310
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.491155	0.309
R-HSA-1280215	Cytokine Signaling in Immune system	0.491570	0.308
R-HSA-9007101	Rab regulation of trafficking	0.496486	0.304
R-HSA-70326	Glucose metabolism	0.496486	0.304
R-HSA-72187	mRNA 3'-end processing	0.498711	0.302
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.502230	0.299
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	0.502230	0.299
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	0.502230	0.299
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.502230	0.299
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	0.502230	0.299
R-HSA-445144	Signal transduction by L1	0.502230	0.299
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	0.507435	0.295
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.507435	0.295
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.508035	0.294
R-HSA-9645723	Diseases of programmed cell death	0.508035	0.294
R-HSA-8878166	Transcriptional regulation by RUNX2	0.508219	0.294
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.515939	0.287
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.515939	0.287
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.515939	0.287
R-HSA-167044	Signalling to RAS	0.515939	0.287
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.515939	0.287
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.515939	0.287
R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	0.515939	0.287
R-HSA-72649	Translation initiation complex formation	0.516060	0.287
R-HSA-5693532	DNA Double-Strand Break Repair	0.518650	0.285
R-HSA-73884	Base Excision Repair	0.521623	0.283
R-HSA-9012852	Signaling by NOTCH3	0.524584	0.280
R-HSA-195721	Signaling by WNT	0.527828	0.278
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.529271	0.276
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.529271	0.276
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.529271	0.276
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.529271	0.276
R-HSA-8949215	Mitochondrial calcium ion transport	0.529271	0.276
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.533007	0.273
R-HSA-72702	Ribosomal scanning and start codon recognition	0.533007	0.273
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.533007	0.273
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.533007	0.273
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.533007	0.273
R-HSA-9612973	Autophagy	0.533936	0.273
R-HSA-9705683	SARS-CoV-2-host interactions	0.538617	0.269
R-HSA-156842	Eukaryotic Translation Elongation	0.541615	0.266
R-HSA-74752	Signaling by Insulin receptor	0.541615	0.266
R-HSA-912694	Regulation of IFNA/IFNB signaling	0.542237	0.266
R-HSA-6803529	FGFR2 alternative splicing	0.542237	0.266
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.542237	0.266
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.542237	0.266
R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m...	0.542237	0.266
R-HSA-9669938	Signaling by KIT in disease	0.542237	0.266
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	0.542237	0.266
R-HSA-6782135	Dual incision in TC-NER	0.549544	0.260
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu...	0.549544	0.260
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.549544	0.260
R-HSA-9609690	HCMV Early Events	0.554568	0.256
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.554673	0.256
R-HSA-977068	Termination of O-glycan biosynthesis	0.554846	0.256
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.554846	0.256
R-HSA-1640170	Cell Cycle	0.561199	0.251
R-HSA-8953897	Cellular responses to stimuli	0.563118	0.249
R-HSA-1227986	Signaling by ERBB2	0.565666	0.247
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.565666	0.247
R-HSA-933542	TRAF6 mediated NF-kB activation	0.567109	0.246
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.567109	0.246
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.567109	0.246
R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	0.567109	0.246
R-HSA-8963898	Plasma lipoprotein assembly	0.567109	0.246
R-HSA-72689	Formation of a pool of free 40S subunits	0.567506	0.246
R-HSA-68886	M Phase	0.569894	0.244
R-HSA-73856	RNA Polymerase II Transcription Termination	0.573569	0.241
R-HSA-9793380	Formation of paraxial mesoderm	0.573569	0.241
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	0.579035	0.237
R-HSA-9932451	SWI/SNF chromatin remodelers	0.579035	0.237
R-HSA-9932444	ATP-dependent chromatin remodelers	0.579035	0.237
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.579035	0.237
R-HSA-2160916	Hyaluronan degradation	0.579035	0.237
R-HSA-1482801	Acyl chain remodelling of PS	0.579035	0.237
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.579035	0.237
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.579035	0.237
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.581368	0.236
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.581368	0.236
R-HSA-376176	Signaling by ROBO receptors	0.585624	0.232
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.586326	0.232
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.586326	0.232
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.586326	0.232
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.589062	0.230
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.589062	0.230
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.590633	0.229
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	0.590633	0.229
R-HSA-1643713	Signaling by EGFR in Cancer	0.590633	0.229
R-HSA-525793	Myogenesis	0.590633	0.229
R-HSA-9703465	Signaling by FLT3 fusion proteins	0.590633	0.229
R-HSA-5357801	Programmed Cell Death	0.598589	0.223
R-HSA-73863	RNA Polymerase I Transcription Termination	0.601912	0.220
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.601912	0.220
R-HSA-201451	Signaling by BMP	0.601912	0.220
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.601912	0.220
R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.601912	0.220
R-HSA-5655332	Signaling by FGFR3 in disease	0.601912	0.220
R-HSA-9759218	Cobalamin (Cbl) metabolism	0.601912	0.220
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	0.604132	0.219
R-HSA-9619483	Activation of AMPK downstream of NMDARs	0.612881	0.213
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.612881	0.213
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	0.612881	0.213
R-HSA-73894	DNA Repair	0.616253	0.210
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.622883	0.206
R-HSA-9709570	Impaired BRCA2 binding to RAD51	0.623549	0.205
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.623549	0.205
R-HSA-5334118	DNA methylation	0.623549	0.205
R-HSA-5654708	Downstream signaling of activated FGFR3	0.623549	0.205
R-HSA-180024	DARPP-32 events	0.623549	0.205
R-HSA-9759475	Regulation of CDH11 Expression and Function	0.623549	0.205
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	0.625948	0.203
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.625948	0.203
R-HSA-381119	Unfolded Protein Response (UPR)	0.632887	0.199
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	0.633010	0.199
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.633887	0.198
R-HSA-8863795	Downregulation of ERBB2 signaling	0.633923	0.198
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.633923	0.198
R-HSA-5654716	Downstream signaling of activated FGFR4	0.633923	0.198
R-HSA-114452	Activation of BH3-only proteins	0.633923	0.198
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.639968	0.194
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.639968	0.194
R-HSA-9679506	SARS-CoV Infections	0.641566	0.193
R-HSA-2129379	Molecules associated with elastic fibres	0.644012	0.191
R-HSA-182971	EGFR downregulation	0.644012	0.191
R-HSA-9833109	Evasion by RSV of host interferon responses	0.644012	0.191
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.646821	0.189
R-HSA-453276	Regulation of mitotic cell cycle	0.646821	0.189
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.650713	0.187
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.650713	0.187
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.653571	0.185
R-HSA-9937080	Developmental Lineage of Multipotent Pancreatic Progenitor Cells	0.653823	0.185
R-HSA-9675126	Diseases of mitotic cell cycle	0.653823	0.185
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.656198	0.183
R-HSA-69620	Cell Cycle Checkpoints	0.657318	0.182
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	0.660218	0.180
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.661620	0.179
R-HSA-166166	MyD88-independent TLR4 cascade	0.661620	0.179
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.663365	0.178
R-HSA-1839124	FGFR1 mutant receptor activation	0.663365	0.178
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	0.663365	0.178
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.663365	0.178
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	0.663365	0.178
R-HSA-354192	Integrin signaling	0.663365	0.178
R-HSA-9013694	Signaling by NOTCH4	0.666762	0.176
R-HSA-390522	Striated Muscle Contraction	0.672644	0.172
R-HSA-5693537	Resolution of D-Loop Structures	0.672644	0.172
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.672644	0.172
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.673204	0.172
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.677516	0.169
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	0.681668	0.166
R-HSA-5696400	Dual Incision in GG-NER	0.681668	0.166
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	0.681668	0.166
R-HSA-1980145	Signaling by NOTCH2	0.681668	0.166
R-HSA-2142845	Hyaluronan metabolism	0.681668	0.166
R-HSA-5205647	Mitophagy	0.681668	0.166
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	0.681668	0.166
R-HSA-901042	Calnexin/calreticulin cycle	0.681668	0.166
R-HSA-168638	NOD1/2 Signaling Pathway	0.681668	0.166
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	0.681668	0.166
R-HSA-9694635	Translation of Structural Proteins	0.685785	0.164
R-HSA-162906	HIV Infection	0.686564	0.163
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.690444	0.161
R-HSA-169911	Regulation of Apoptosis	0.690444	0.161
R-HSA-5654696	Downstream signaling of activated FGFR2	0.690444	0.161
R-HSA-5654687	Downstream signaling of activated FGFR1	0.690444	0.161
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.690444	0.161
R-HSA-913531	Interferon Signaling	0.690488	0.161
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.691925	0.160
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.692855	0.159
R-HSA-5617833	Cilium Assembly	0.692887	0.159
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.697844	0.156
R-HSA-9659379	Sensory processing of sound	0.697967	0.156
R-HSA-446652	Interleukin-1 family signaling	0.698016	0.156
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	0.698978	0.156
R-HSA-212300	PRC2 methylates histones and DNA	0.698978	0.156
R-HSA-114604	GPVI-mediated activation cascade	0.698978	0.156
R-HSA-163560	Triglyceride catabolism	0.698978	0.156
R-HSA-9682385	FLT3 signaling in disease	0.698978	0.156
R-HSA-1839126	FGFR2 mutant receptor activation	0.698978	0.156
R-HSA-9694516	SARS-CoV-2 Infection	0.701560	0.154
R-HSA-5654738	Signaling by FGFR2	0.703909	0.152
R-HSA-5693538	Homology Directed Repair	0.712442	0.147
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.715349	0.145
R-HSA-1566948	Elastic fibre formation	0.715349	0.145
R-HSA-202131	Metabolism of nitric oxide: NOS3 activation and regulation	0.715349	0.145
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.715349	0.145
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.715503	0.145
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.717186	0.144
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.717186	0.144
R-HSA-9610379	HCMV Late Events	0.719165	0.143
R-HSA-8939211	ESR-mediated signaling	0.722100	0.141
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.723198	0.141
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.723198	0.141
R-HSA-8964043	Plasma lipoprotein clearance	0.723198	0.141
R-HSA-446728	Cell junction organization	0.725337	0.139
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.726714	0.139
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.726714	0.139
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.730831	0.136
R-HSA-9670095	Inhibition of DNA recombination at telomere	0.730831	0.136
R-HSA-5260271	Diseases of Immune System	0.730831	0.136
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.730831	0.136
R-HSA-71240	Tryptophan catabolism	0.730831	0.136
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.731055	0.136
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.731055	0.136
R-HSA-6802957	Oncogenic MAPK signaling	0.732178	0.135
R-HSA-5687128	MAPK6/MAPK4 signaling	0.732178	0.135
R-HSA-6794362	Protein-protein interactions at synapses	0.732178	0.135
R-HSA-9658195	Leishmania infection	0.734697	0.134
R-HSA-9824443	Parasitic Infection Pathways	0.734697	0.134
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.738255	0.132
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.738255	0.132
R-HSA-162909	Host Interactions of HIV factors	0.740000	0.131
R-HSA-110329	Cleavage of the damaged pyrimidine	0.752494	0.123
R-HSA-73928	Depyrimidination	0.752494	0.123
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.752494	0.123
R-HSA-156902	Peptide chain elongation	0.753113	0.123
R-HSA-9710421	Defective pyroptosis	0.759321	0.120
R-HSA-5654743	Signaling by FGFR4	0.759321	0.120
R-HSA-1433557	Signaling by SCF-KIT	0.759321	0.120
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.759321	0.120
R-HSA-112310	Neurotransmitter release cycle	0.763043	0.117
R-HSA-202424	Downstream TCR signaling	0.763043	0.117
R-HSA-9609646	HCMV Infection	0.763971	0.117
R-HSA-3214858	RMTs methylate histone arginines	0.765960	0.116
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.765960	0.116
R-HSA-199991	Membrane Trafficking	0.767275	0.115
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	0.767877	0.115
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.767877	0.115
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.772416	0.112
R-HSA-5654741	Signaling by FGFR3	0.772416	0.112
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.772416	0.112
R-HSA-72306	tRNA processing	0.772516	0.112
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.772625	0.112
R-HSA-1483257	Phospholipid metabolism	0.775432	0.110
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	0.777288	0.109
R-HSA-9772573	Late SARS-CoV-2 Infection Events	0.777288	0.109
R-HSA-72165	mRNA Splicing - Minor Pathway	0.778695	0.109
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.778695	0.109
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	0.778695	0.109
R-HSA-2299718	Condensation of Prophase Chromosomes	0.778695	0.109
R-HSA-9675135	Diseases of DNA repair	0.778695	0.109
R-HSA-9861718	Regulation of pyruvate metabolism	0.778695	0.109
R-HSA-5689880	Ub-specific processing proteases	0.782851	0.106
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.784801	0.105
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	0.784801	0.105
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.784801	0.105
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.784801	0.105
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.785036	0.105
R-HSA-9837999	Mitochondrial protein degradation	0.786364	0.104
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.789531	0.103
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.790738	0.102
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	0.790779	0.102
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	0.795113	0.100
R-HSA-72764	Eukaryotic Translation Termination	0.795113	0.100
R-HSA-157858	Gap junction trafficking and regulation	0.796513	0.099
R-HSA-6807878	COPI-mediated anterograde transport	0.799368	0.097
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.799368	0.097
R-HSA-9748787	Azathioprine ADME	0.802128	0.096
R-HSA-5683057	MAPK family signaling cascades	0.803163	0.095
R-HSA-912446	Meiotic recombination	0.807588	0.093
R-HSA-1169091	Activation of NF-kappaB in B cells	0.807588	0.093
R-HSA-9864848	Complex IV assembly	0.807588	0.093
R-HSA-190236	Signaling by FGFR	0.807644	0.093
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.812899	0.090
R-HSA-73772	RNA Polymerase I Promoter Escape	0.812899	0.090
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	0.818063	0.087
R-HSA-8948751	Regulation of PTEN stability and activity	0.818063	0.087
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.818063	0.087
R-HSA-445355	Smooth Muscle Contraction	0.818063	0.087
R-HSA-2408557	Selenocysteine synthesis	0.819488	0.086
R-HSA-9020702	Interleukin-1 signaling	0.819488	0.086
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.823084	0.085
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.823084	0.085
R-HSA-2559580	Oxidative Stress Induced Senescence	0.823289	0.084
R-HSA-192823	Viral mRNA Translation	0.827018	0.082
R-HSA-1500931	Cell-Cell communication	0.827611	0.082
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.827968	0.082
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.827968	0.082
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.830676	0.081
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	0.830676	0.081
R-HSA-9860931	Response of endothelial cells to shear stress	0.830676	0.081
R-HSA-5654736	Signaling by FGFR1	0.832717	0.080
R-HSA-168898	Toll-like Receptor Cascades	0.837214	0.077
R-HSA-5621480	Dectin-2 family	0.837335	0.077
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.837335	0.077
R-HSA-418346	Platelet homeostasis	0.841235	0.075
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.841798	0.075
R-HSA-9824446	Viral Infection Pathways	0.844271	0.074
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	0.844620	0.073
R-HSA-8979227	Triglyceride metabolism	0.846193	0.073
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.846193	0.073
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.846845	0.072
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.850440	0.070
R-HSA-5362517	Signaling by Retinoic Acid	0.850440	0.070
R-HSA-157118	Signaling by NOTCH	0.850740	0.070
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	0.853107	0.069
R-HSA-202403	TCR signaling	0.854386	0.068
R-HSA-8939902	Regulation of RUNX2 expression and activity	0.854570	0.068
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.858586	0.066
R-HSA-1268020	Mitochondrial protein import	0.858586	0.066
R-HSA-375165	NCAM signaling for neurite out-growth	0.858586	0.066
R-HSA-2871796	FCERI mediated MAPK activation	0.860583	0.065
R-HSA-5673001	RAF/MAP kinase cascade	0.861415	0.065
R-HSA-6799198	Complex I biogenesis	0.862492	0.064
R-HSA-373755	Semaphorin interactions	0.862492	0.064
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.863590	0.064
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.866289	0.062
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.866538	0.062
R-HSA-9855142	Cellular responses to mechanical stimuli	0.866538	0.062
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.866753	0.062
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.868748	0.061
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.873574	0.059
R-HSA-5633007	Regulation of TP53 Activity	0.873626	0.059
R-HSA-5684996	MAPK1/MAPK3 signaling	0.874823	0.058
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.877066	0.057
R-HSA-913709	O-linked glycosylation of mucins	0.880462	0.055
R-HSA-397014	Muscle contraction	0.887743	0.052
R-HSA-5619102	SLC transporter disorders	0.889459	0.051
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.890099	0.051
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.890099	0.051
R-HSA-9759194	Nuclear events mediated by NFE2L2	0.890550	0.050
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.893136	0.049
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	0.893136	0.049
R-HSA-9734767	Developmental Cell Lineages	0.896022	0.048
R-HSA-69052	Switching of origins to a post-replicative state	0.896089	0.048
R-HSA-4086398	Ca2+ pathway	0.896089	0.048
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.897689	0.047
R-HSA-69473	G2/M DNA damage checkpoint	0.898961	0.046
R-HSA-5621481	C-type lectin receptors (CLRs)	0.899658	0.046
R-HSA-69206	G1/S Transition	0.902095	0.045
R-HSA-8951664	Neddylation	0.904110	0.044
R-HSA-9711123	Cellular response to chemical stress	0.904128	0.044
R-HSA-114608	Platelet degranulation	0.906387	0.043
R-HSA-191273	Cholesterol biosynthesis	0.909677	0.041
R-HSA-9675108	Nervous system development	0.912639	0.040
R-HSA-76002	Platelet activation, signaling and aggregation	0.913126	0.039
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.914602	0.039
R-HSA-5576891	Cardiac conduction	0.916361	0.038
R-HSA-5693607	Processing of DNA double-strand break ends	0.916963	0.038
R-HSA-8856688	Golgi-to-ER retrograde transport	0.918232	0.037
R-HSA-1500620	Meiosis	0.925774	0.033
R-HSA-3700989	Transcriptional Regulation by TP53	0.925992	0.033
R-HSA-163685	Integration of energy metabolism	0.927012	0.033
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.928297	0.032
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.929823	0.032
R-HSA-9948299	Ribosome-associated quality control	0.930269	0.031
R-HSA-70268	Pyruvate metabolism	0.931764	0.031
R-HSA-390466	Chaperonin-mediated protein folding	0.931764	0.031
R-HSA-438064	Post NMDA receptor activation events	0.931764	0.031
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.934037	0.030
R-HSA-1236974	ER-Phagosome pathway	0.935487	0.029
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.938995	0.027
R-HSA-2682334	EPH-Ephrin signaling	0.942335	0.026
R-HSA-391251	Protein folding	0.942335	0.026
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.943298	0.025
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.943773	0.025
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge...	0.943931	0.025
R-HSA-68867	Assembly of the pre-replicative complex	0.943931	0.025
R-HSA-199977	ER to Golgi Anterograde Transport	0.944594	0.025
R-HSA-1474290	Collagen formation	0.945483	0.024
R-HSA-1280218	Adaptive Immune System	0.946612	0.024
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.946991	0.024
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.949501	0.023
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.949885	0.022
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.949885	0.022
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.950662	0.022
R-HSA-157579	Telomere Maintenance	0.951272	0.022
R-HSA-8957275	Post-translational protein phosphorylation	0.952621	0.021
R-HSA-5653656	Vesicle-mediated transport	0.954556	0.020
R-HSA-422475	Axon guidance	0.954612	0.020
R-HSA-9009391	Extra-nuclear estrogen signaling	0.956448	0.019
R-HSA-9711097	Cellular response to starvation	0.957108	0.019
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.957654	0.019
R-HSA-877300	Interferon gamma signaling	0.958101	0.019
R-HSA-111885	Opioid Signalling	0.959967	0.018
R-HSA-418990	Adherens junctions interactions	0.962078	0.017
R-HSA-2408522	Selenoamino acid metabolism	0.962745	0.016
R-HSA-69239	Synthesis of DNA	0.964221	0.016
R-HSA-1236975	Antigen processing-Cross presentation	0.965212	0.015
R-HSA-2672351	Stimuli-sensing channels	0.965212	0.015
R-HSA-69002	DNA Replication Pre-Initiation	0.966176	0.015
R-HSA-6803157	Antimicrobial peptides	0.968024	0.014
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.970595	0.013
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.970595	0.013
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.971424	0.013
R-HSA-72312	rRNA processing	0.971810	0.012
R-HSA-909733	Interferon alpha/beta signaling	0.972986	0.012
R-HSA-373760	L1CAM interactions	0.973735	0.012
R-HSA-611105	Respiratory electron transport	0.973897	0.011
R-HSA-2980736	Peptide hormone metabolism	0.974463	0.011
R-HSA-168256	Immune System	0.974838	0.011
R-HSA-73886	Chromosome Maintenance	0.977179	0.010
R-HSA-2132295	MHC class II antigen presentation	0.978427	0.009
R-HSA-6809371	Formation of the cornified envelope	0.979025	0.009
R-HSA-5619115	Disorders of transmembrane transporters	0.979594	0.009
R-HSA-69481	G2/M Checkpoints	0.981257	0.008
R-HSA-421270	Cell-cell junction organization	0.981295	0.008
R-HSA-1474165	Reproduction	0.983252	0.007
R-HSA-597592	Post-translational protein modification	0.983714	0.007
R-HSA-1474228	Degradation of the extracellular matrix	0.984169	0.007
R-HSA-428157	Sphingolipid metabolism	0.985001	0.007
R-HSA-948021	Transport to the Golgi and subsequent modification	0.985362	0.006
R-HSA-1483206	Glycerophospholipid biosynthesis	0.985713	0.006
R-HSA-3858494	Beta-catenin independent WNT signaling	0.986247	0.006
R-HSA-72766	Translation	0.986579	0.006
R-HSA-5173105	O-linked glycosylation	0.986629	0.006
R-HSA-8957322	Metabolism of steroids	0.986792	0.006
R-HSA-5663205	Infectious disease	0.988343	0.005
R-HSA-1643685	Disease	0.989115	0.005
R-HSA-2871837	FCERI mediated NF-kB activation	0.989326	0.005
R-HSA-69242	S Phase	0.990463	0.004
R-HSA-9609507	Protein localization	0.991717	0.004
R-HSA-69306	DNA Replication	0.991717	0.004
R-HSA-202733	Cell surface interactions at the vascular wall	0.993962	0.003
R-HSA-109582	Hemostasis	0.994898	0.002
R-HSA-418555	G alpha (s) signalling events	0.995152	0.002
R-HSA-112315	Transmission across Chemical Synapses	0.996301	0.002
R-HSA-3781865	Diseases of glycosylation	0.996641	0.001
R-HSA-1474244	Extracellular matrix organization	0.996927	0.001
R-HSA-416476	G alpha (q) signalling events	0.996928	0.001
R-HSA-983712	Ion channel transport	0.997084	0.001
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.997224	0.001
R-HSA-6798695	Neutrophil degranulation	0.997337	0.001
R-HSA-1630316	Glycosaminoglycan metabolism	0.997395	0.001
R-HSA-1428517	Aerobic respiration and respiratory electron transport	0.997567	0.001
R-HSA-6805567	Keratinization	0.998247	0.001
R-HSA-168249	Innate Immune System	0.998383	0.001
R-HSA-446203	Asparagine N-linked glycosylation	0.998425	0.001
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.998520	0.001
R-HSA-9748784	Drug ADME	0.998751	0.001
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.999111	0.000
R-HSA-15869	Metabolism of nucleotides	0.999250	0.000
R-HSA-392499	Metabolism of proteins	0.999624	0.000
R-HSA-112316	Neuronal System	0.999890	0.000
R-HSA-418594	G alpha (i) signalling events	0.999926	0.000
R-HSA-5668914	Diseases of metabolism	0.999956	0.000
R-HSA-388396	GPCR downstream signalling	0.999962	0.000
R-HSA-556833	Metabolism of lipids	0.999971	0.000
R-HSA-196854	Metabolism of vitamins and cofactors	0.999980	0.000
R-HSA-372790	Signaling by GPCR	0.999994	0.000
R-HSA-71291	Metabolism of amino acids and derivatives	0.999998	0.000
R-HSA-382551	Transport of small molecules	1.000000	0.000
R-HSA-9709957	Sensory Perception	1.000000	0.000
R-HSA-1430728	Metabolism	1.000000	-0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CDK18	0.886	0.777	1	0.936
HIPK2	0.886	0.720	1	0.939
CDK19	0.884	0.747	1	0.940
KIS	0.884	0.668	1	0.935
CLK3	0.882	0.534	1	0.808
CDK1	0.880	0.741	1	0.946
JNK2	0.880	0.793	1	0.951
CDK8	0.880	0.737	1	0.936
DYRK2	0.879	0.703	1	0.932
P38G	0.879	0.777	1	0.938
CDK7	0.879	0.739	1	0.943
CDK17	0.877	0.763	1	0.930
P38B	0.877	0.782	1	0.943
CDK3	0.876	0.680	1	0.936
ERK1	0.875	0.756	1	0.946
HIPK4	0.875	0.527	1	0.819
CDK5	0.874	0.724	1	0.932
CDK13	0.873	0.722	1	0.943
JNK3	0.872	0.770	1	0.947
DYRK4	0.871	0.703	1	0.953
CDK12	0.871	0.724	1	0.946
P38D	0.870	0.764	1	0.939
HIPK1	0.869	0.651	1	0.921
P38A	0.868	0.746	1	0.929
CDK16	0.868	0.731	1	0.927
SRPK1	0.866	0.353	-3	0.741
NLK	0.866	0.652	1	0.840
CDK9	0.864	0.696	1	0.945
CDK10	0.863	0.682	1	0.937
ERK5	0.862	0.439	1	0.781
CDK14	0.862	0.717	1	0.933
CLK2	0.860	0.426	-3	0.732
DYRK1B	0.860	0.652	1	0.934
COT	0.857	0.058	2	0.885
MAK	0.857	0.574	-2	0.869
DYRK1A	0.857	0.567	1	0.911
MTOR	0.856	0.250	1	0.671
ERK2	0.856	0.704	1	0.935
HIPK3	0.856	0.615	1	0.900
ICK	0.855	0.417	-3	0.826
CDKL5	0.854	0.245	-3	0.777
SRPK2	0.851	0.271	-3	0.659
JNK1	0.851	0.682	1	0.939
CLK1	0.849	0.378	-3	0.714
CLK4	0.849	0.355	-3	0.736
DYRK3	0.849	0.506	1	0.899
CDKL1	0.848	0.193	-3	0.781
NDR2	0.848	0.087	-3	0.854
PIM3	0.847	0.065	-3	0.835
CDK6	0.847	0.676	1	0.931
CDC7	0.846	-0.010	1	0.576
CDK2	0.846	0.517	1	0.904
CDK4	0.846	0.696	1	0.941
MOS	0.846	0.084	1	0.606
PRKD1	0.845	0.108	-3	0.835
SRPK3	0.842	0.236	-3	0.704
RSK2	0.841	0.070	-3	0.757
PRPK	0.840	-0.038	-1	0.879
ATR	0.839	0.016	1	0.596
SKMLCK	0.838	0.063	-2	0.891
MOK	0.838	0.492	1	0.858
PRP4	0.837	0.421	-3	0.767
PRKD2	0.837	0.063	-3	0.765
GRK1	0.837	0.083	-2	0.805
P90RSK	0.837	0.058	-3	0.760
IKKB	0.837	-0.107	-2	0.740
TBK1	0.835	-0.104	1	0.492
CHAK2	0.835	0.025	-1	0.841
AURC	0.835	0.085	-2	0.694
NDR1	0.834	0.003	-3	0.824
PIM1	0.833	0.063	-3	0.768
CAMK1B	0.833	-0.017	-3	0.819
RSK3	0.833	0.035	-3	0.747
IKKE	0.832	-0.117	1	0.489
PDHK4	0.832	-0.160	1	0.612
RAF1	0.832	-0.164	1	0.564
WNK1	0.831	-0.031	-2	0.910
PKN3	0.831	-0.012	-3	0.808
MST4	0.831	-0.007	2	0.878
BMPR2	0.831	-0.145	-2	0.868
NUAK2	0.830	0.018	-3	0.816
NEK6	0.830	-0.034	-2	0.830
GCN2	0.830	-0.203	2	0.809
CAMLCK	0.829	0.029	-2	0.867
PKCD	0.829	0.033	2	0.807
NIK	0.829	-0.028	-3	0.842
PKN2	0.829	-0.019	-3	0.811
RSK4	0.828	0.078	-3	0.746
MLK2	0.828	0.015	2	0.847
PKACG	0.828	0.016	-2	0.769
IKKA	0.828	-0.030	-2	0.731
MAPKAPK3	0.828	-0.013	-3	0.768
DSTYK	0.828	-0.144	2	0.901
MAPKAPK2	0.827	0.017	-3	0.731
ULK2	0.827	-0.187	2	0.793
GRK5	0.827	-0.112	-3	0.819
DAPK2	0.827	0.006	-3	0.834
MLK3	0.826	0.019	2	0.771
LATS2	0.826	-0.009	-5	0.733
MLK1	0.826	-0.102	2	0.839
CAMK2D	0.826	-0.037	-3	0.815
RIPK3	0.826	-0.103	3	0.730
TGFBR2	0.825	-0.077	-2	0.765
CAMK2G	0.825	-0.111	2	0.794
PDHK1	0.825	-0.184	1	0.585
P70S6KB	0.825	0.011	-3	0.763
PKACB	0.824	0.069	-2	0.702
PKCA	0.824	0.054	2	0.755
ERK7	0.824	0.254	2	0.567
MARK4	0.824	-0.043	4	0.815
GRK7	0.824	0.064	1	0.554
PKCB	0.823	0.024	2	0.767
BMPR1B	0.823	0.021	1	0.552
AMPKA1	0.823	-0.041	-3	0.834
MNK2	0.823	0.022	-2	0.815
LATS1	0.822	0.086	-3	0.870
PAK1	0.821	0.001	-2	0.823
PKCG	0.821	0.013	2	0.762
BCKDK	0.821	-0.146	-1	0.809
NEK7	0.821	-0.181	-3	0.825
CAMK2A	0.821	0.021	2	0.789
MPSK1	0.820	0.198	1	0.559
GSK3A	0.820	0.221	4	0.486
PKG2	0.820	0.048	-2	0.707
AMPKA2	0.820	-0.020	-3	0.805
MASTL	0.820	-0.152	-2	0.819
HUNK	0.820	-0.147	2	0.819
IRE1	0.819	-0.067	1	0.533
PRKD3	0.819	0.011	-3	0.722
AKT2	0.819	0.060	-3	0.666
NEK9	0.818	-0.151	2	0.853
PAK3	0.818	-0.028	-2	0.813
DLK	0.818	-0.149	1	0.574
TSSK1	0.818	-0.015	-3	0.856
DNAPK	0.818	0.005	1	0.528
PRKX	0.817	0.070	-3	0.682
MNK1	0.817	0.024	-2	0.818
SGK3	0.817	0.037	-3	0.754
TSSK2	0.817	-0.050	-5	0.831
MSK2	0.817	-0.018	-3	0.734
MSK1	0.817	0.024	-3	0.735
PKCZ	0.817	-0.006	2	0.801
CAMK2B	0.817	-0.025	2	0.767
GRK6	0.816	-0.124	1	0.568
PHKG1	0.816	-0.045	-3	0.807
VRK2	0.816	0.093	1	0.647
SMG1	0.815	-0.035	1	0.558
PAK6	0.815	0.028	-2	0.736
ULK1	0.815	-0.207	-3	0.774
TGFBR1	0.814	-0.025	-2	0.784
AURB	0.814	0.020	-2	0.688
RIPK1	0.814	-0.186	1	0.547
ALK4	0.814	-0.049	-2	0.813
NIM1	0.813	-0.095	3	0.764
WNK3	0.813	-0.244	1	0.545
ATM	0.813	-0.080	1	0.545
YSK4	0.812	-0.111	1	0.519
QSK	0.812	-0.026	4	0.790
PIM2	0.812	0.043	-3	0.718
GRK4	0.812	-0.158	-2	0.813
PKR	0.812	-0.066	1	0.570
PKCH	0.811	-0.035	2	0.746
MLK4	0.811	-0.075	2	0.747
ANKRD3	0.810	-0.201	1	0.582
IRE2	0.810	-0.067	2	0.757
CAMK4	0.810	-0.121	-3	0.787
TTBK2	0.810	-0.190	2	0.707
NEK2	0.810	-0.109	2	0.832
MELK	0.809	-0.077	-3	0.781
MST3	0.809	0.010	2	0.869
TLK2	0.809	-0.078	1	0.533
MYLK4	0.808	-0.021	-2	0.794
PAK2	0.808	-0.051	-2	0.804
CHAK1	0.808	-0.128	2	0.800
PASK	0.808	0.059	-3	0.862
CK1E	0.807	-0.000	-3	0.542
MEK1	0.807	-0.162	2	0.852
AURA	0.807	0.004	-2	0.659
FAM20C	0.807	-0.030	2	0.588
QIK	0.806	-0.124	-3	0.801
BRSK1	0.806	-0.064	-3	0.769
NUAK1	0.806	-0.070	-3	0.760
DCAMKL1	0.806	-0.028	-3	0.772
PKACA	0.805	0.036	-2	0.656
DRAK1	0.805	-0.095	1	0.532
GSK3B	0.804	0.071	4	0.478
ACVR2B	0.804	-0.087	-2	0.764
SIK	0.804	-0.063	-3	0.730
AKT1	0.804	0.030	-3	0.692
ALK2	0.804	-0.068	-2	0.790
ACVR2A	0.804	-0.094	-2	0.751
BRSK2	0.804	-0.096	-3	0.785
TAO3	0.804	-0.009	1	0.562
PLK1	0.803	-0.171	-2	0.754
MARK3	0.802	-0.052	4	0.735
PINK1	0.802	0.046	1	0.689
PKCT	0.802	-0.029	2	0.754
CHK1	0.802	-0.052	-3	0.812
GRK2	0.801	-0.079	-2	0.711
NEK5	0.801	-0.090	1	0.552
MEK5	0.801	-0.155	2	0.841
ZAK	0.799	-0.141	1	0.531
BUB1	0.799	0.140	-5	0.787
MEKK2	0.799	-0.115	2	0.823
PKCE	0.798	0.021	2	0.749
AKT3	0.798	0.054	-3	0.623
WNK4	0.798	-0.118	-2	0.902
CK1D	0.798	0.010	-3	0.493
PLK4	0.798	-0.118	2	0.617
BMPR1A	0.797	-0.044	1	0.529
MEKK1	0.797	-0.154	1	0.548
MAPKAPK5	0.797	-0.117	-3	0.695
GCK	0.797	0.004	1	0.559
PKCI	0.797	-0.027	2	0.768
IRAK4	0.797	-0.119	1	0.525
MARK2	0.797	-0.086	4	0.701
LKB1	0.796	0.001	-3	0.823
PERK	0.796	-0.179	-2	0.809
MEKK3	0.796	-0.191	1	0.556
CAMK1G	0.796	-0.079	-3	0.722
SGK1	0.796	0.056	-3	0.600
SSTK	0.795	-0.042	4	0.778
SMMLCK	0.795	-0.042	-3	0.782
P70S6K	0.795	-0.028	-3	0.676
PAK5	0.795	-0.016	-2	0.682
CK1G1	0.794	-0.052	-3	0.528
PLK3	0.794	-0.169	2	0.757
NEK11	0.794	-0.119	1	0.559
TNIK	0.793	0.015	3	0.877
PDK1	0.793	-0.046	1	0.565
BRAF	0.793	-0.169	-4	0.808
SNRK	0.793	-0.200	2	0.677
PAK4	0.793	0.001	-2	0.689
GAK	0.792	-0.029	1	0.587
DCAMKL2	0.792	-0.076	-3	0.778
HPK1	0.792	-0.018	1	0.554
MAP3K15	0.792	-0.030	1	0.530
HRI	0.792	-0.220	-2	0.822
CK1A2	0.792	-0.019	-3	0.491
TAO2	0.791	-0.068	2	0.860
HGK	0.791	-0.028	3	0.873
KHS1	0.791	0.025	1	0.539
MEKK6	0.791	-0.063	1	0.553
MARK1	0.790	-0.118	4	0.758
PHKG2	0.790	-0.108	-3	0.754
EEF2K	0.789	-0.035	3	0.842
DAPK3	0.789	-0.019	-3	0.776
CAMKK2	0.789	-0.101	-2	0.757
TLK1	0.789	-0.182	-2	0.798
KHS2	0.789	0.032	1	0.556
PKN1	0.788	-0.031	-3	0.693
SBK	0.788	0.093	-3	0.551
ROCK2	0.788	0.030	-3	0.774
GRK3	0.788	-0.080	-2	0.669
MINK	0.787	-0.079	1	0.533
LRRK2	0.787	-0.032	2	0.853
CAMKK1	0.787	-0.179	-2	0.748
LOK	0.786	-0.049	-2	0.778
CAMK1D	0.786	-0.053	-3	0.663
NEK4	0.785	-0.138	1	0.526
PBK	0.785	-0.001	1	0.529
MRCKB	0.785	0.011	-3	0.707
NEK8	0.785	-0.193	2	0.832
MST2	0.785	-0.123	1	0.549
DAPK1	0.784	-0.023	-3	0.756
CK2A2	0.784	-0.048	1	0.470
NEK1	0.783	-0.096	1	0.527
VRK1	0.783	-0.100	2	0.843
TAK1	0.783	-0.138	1	0.546
SLK	0.782	-0.062	-2	0.727
MRCKA	0.781	-0.009	-3	0.725
CHK2	0.781	-0.034	-3	0.612
PDHK3_TYR	0.780	0.286	4	0.905
TTBK1	0.779	-0.208	2	0.619
HASPIN	0.778	0.020	-1	0.708
YSK1	0.778	-0.085	2	0.833
DMPK1	0.778	0.041	-3	0.730
CK2A1	0.776	-0.051	1	0.457
MST1	0.775	-0.144	1	0.531
CRIK	0.775	0.042	-3	0.701
CAMK1A	0.775	-0.039	-3	0.635
OSR1	0.774	-0.050	2	0.826
IRAK1	0.773	-0.303	-1	0.780
STK33	0.773	-0.153	2	0.615
PKG1	0.772	-0.023	-2	0.626
LIMK2_TYR	0.772	0.195	-3	0.870
PDHK4_TYR	0.771	0.136	2	0.887
ROCK1	0.771	-0.005	-3	0.725
TESK1_TYR	0.770	0.097	3	0.878
PLK2	0.769	-0.114	-3	0.728
MYO3B	0.769	-0.041	2	0.845
MAP2K4_TYR	0.769	0.062	-1	0.889
MEK2	0.768	-0.232	2	0.822
PKMYT1_TYR	0.768	0.131	3	0.846
NEK3	0.768	-0.136	1	0.523
BIKE	0.766	-0.023	1	0.510
MAP2K6_TYR	0.766	0.039	-1	0.888
ASK1	0.765	-0.098	1	0.520
MAP2K7_TYR	0.764	-0.062	2	0.862
RIPK2	0.763	-0.283	1	0.494
TAO1	0.762	-0.091	1	0.501
BMPR2_TYR	0.762	0.002	-1	0.866
TTK	0.761	-0.124	-2	0.783
PDHK1_TYR	0.761	-0.023	-1	0.883
MYO3A	0.761	-0.088	1	0.535
CK1A	0.761	-0.034	-3	0.407
AAK1	0.760	0.032	1	0.459
YANK3	0.758	-0.070	2	0.392
PINK1_TYR	0.757	-0.169	1	0.596
RET	0.756	-0.101	1	0.560
LIMK1_TYR	0.755	-0.040	2	0.856
TXK	0.752	-0.007	1	0.557
CSF1R	0.752	-0.071	3	0.777
EPHA6	0.752	-0.065	-1	0.838
ROS1	0.752	-0.095	3	0.757
JAK2	0.751	-0.096	1	0.561
EPHB4	0.751	-0.072	-1	0.824
MST1R	0.751	-0.109	3	0.795
ABL2	0.751	-0.058	-1	0.813
TYRO3	0.751	-0.121	3	0.784
ALPHAK3	0.750	-0.127	-1	0.774
TYK2	0.749	-0.197	1	0.545
TNK2	0.749	-0.040	3	0.734
TNNI3K_TYR	0.748	0.005	1	0.574
ABL1	0.748	-0.072	-1	0.809
FGR	0.747	-0.119	1	0.564
NEK10_TYR	0.747	-0.084	1	0.476
JAK1	0.746	-0.046	1	0.515
DDR1	0.746	-0.144	4	0.813
STLK3	0.746	-0.198	1	0.501
TNK1	0.745	-0.039	3	0.770
JAK3	0.745	-0.132	1	0.548
YES1	0.745	-0.105	-1	0.852
ITK	0.744	-0.088	-1	0.819
LCK	0.742	-0.072	-1	0.837
FGFR2	0.740	-0.101	3	0.769
FER	0.740	-0.196	1	0.579
KDR	0.740	-0.099	3	0.733
HCK	0.740	-0.138	-1	0.837
SRMS	0.739	-0.149	1	0.560
KIT	0.739	-0.140	3	0.776
BLK	0.739	-0.066	-1	0.828
EPHA4	0.738	-0.100	2	0.762
MERTK	0.738	-0.114	3	0.751
INSRR	0.738	-0.173	3	0.722
EPHB1	0.737	-0.154	1	0.565
TEK	0.736	-0.079	3	0.712
BMX	0.736	-0.085	-1	0.733
MET	0.735	-0.114	3	0.764
AXL	0.735	-0.155	3	0.749
PDGFRB	0.735	-0.224	3	0.786
FGFR1	0.735	-0.109	3	0.735
WEE1_TYR	0.735	-0.094	-1	0.775
EPHB3	0.735	-0.150	-1	0.809
DDR2	0.734	-0.027	3	0.704
FYN	0.732	-0.075	-1	0.813
EPHB2	0.731	-0.160	-1	0.798
FLT3	0.731	-0.231	3	0.783
TEC	0.731	-0.149	-1	0.751
CK1G3	0.730	-0.064	-3	0.361
PDGFRA	0.729	-0.236	3	0.785
FLT1	0.729	-0.156	-1	0.817
FGFR3	0.728	-0.123	3	0.736
BTK	0.728	-0.224	-1	0.795
EPHA7	0.728	-0.128	2	0.762
ALK	0.727	-0.187	3	0.690
PTK6	0.725	-0.227	-1	0.768
PTK2B	0.725	-0.105	-1	0.785
EPHA1	0.725	-0.162	3	0.742
LTK	0.725	-0.195	3	0.715
FRK	0.725	-0.162	-1	0.834
YANK2	0.724	-0.097	2	0.409
ERBB2	0.723	-0.211	1	0.519
NTRK3	0.723	-0.165	-1	0.777
NTRK1	0.722	-0.259	-1	0.820
EPHA3	0.722	-0.178	2	0.731
LYN	0.722	-0.154	3	0.700
INSR	0.721	-0.207	3	0.704
MATK	0.720	-0.135	-1	0.728
FLT4	0.720	-0.217	3	0.729
SRC	0.720	-0.138	-1	0.809
EGFR	0.719	-0.136	1	0.458
NTRK2	0.718	-0.276	3	0.724
CSK	0.717	-0.172	2	0.765
SYK	0.717	-0.081	-1	0.759
PTK2	0.717	-0.065	-1	0.765
EPHA8	0.716	-0.149	-1	0.785
EPHA5	0.715	-0.172	2	0.743
FGFR4	0.715	-0.140	-1	0.764
CK1G2	0.711	-0.069	-3	0.450
MUSK	0.709	-0.177	1	0.443
ERBB4	0.707	-0.114	1	0.475
EPHA2	0.706	-0.149	-1	0.753
ZAP70	0.705	-0.051	-1	0.690
IGF1R	0.703	-0.204	3	0.639
FES	0.691	-0.187	-1	0.713