Motif 196 (n=106)

Position-wise Probabilities

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uniprot genes site source protein function
A0A087X0R7 SENP3-EIF4A1 S118 ochoa SENP3-EIF4A1 readthrough (NMD candidate) None
A0A0U1RQV5 None S26 ochoa Eukaryotic translation initiation factor 6 None
A1A5D9 BICDL2 S330 ochoa BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) None
K7ELQ4 ATF7-NPFF S311 ochoa ATF7-NPFF readthrough None
K7EQG2 None S30 ochoa Uncharacterized protein None
O14640 DVL1 S126 ochoa Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14686 KMT2D S2269 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O15069 NACAD S1130 ochoa NAC-alpha domain-containing protein 1 May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.
O60237 PPP1R12B S412 ochoa Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
O60353 FZD6 S683 ochoa Frizzled-6 (Fz-6) (hFz6) Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}.
O94916 NFAT5 S1197 psp Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}.
P04150 NR3C1 T411 ochoa Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.
P15884 TCF4 S340 ochoa Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.
P26651 ZFP36 T257 ochoa mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}.
P33240 CSTF2 S120 ochoa Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}.
P46092 CCR10 S329 ochoa C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2) Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
P46379 BAG6 S985 ochoa Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.
P54253 ATXN1 Y247 ochoa Ataxin-1 (Spinocerebellar ataxia type 1 protein) Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}.
P54725 RAD23A S100 ochoa UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}.
P55884 EIF3B S95 ochoa Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P56537 EIF6 S174 ochoa|psp Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}.
P61289 PSME3 S75 ochoa Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.
P98171 ARHGAP4 S906 ochoa Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.
Q00978 IRF9 S253 psp Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}.
Q02086 SP2 S187 ochoa Transcription factor Sp2 Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Q04637 EIF4G1 S204 ochoa Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.
Q07157 TJP1 S1579 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q07889 SOS1 S1229 ochoa Son of sevenless homolog 1 (SOS-1) Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}.
Q08462 ADCY2 S472 ochoa Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}.
Q09472 EP300 S106 psp Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.
Q12888 TP53BP1 S1437 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12979 ABR S366 ochoa Active breakpoint cluster region-related protein Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}.
Q12986 NFX1 S1095 ochoa Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
Q13207 TBX2 S386 ochoa T-box transcription factor TBX2 (T-box protein 2) Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}.
Q13469 NFATC2 S808 ochoa Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}.
Q13470 TNK1 S96 ochoa Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q13492 PICALM S474 ochoa Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.
Q14686 NCOA6 S1240 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q16513 PKN2 S622 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q2KHR3 QSER1 S759 ochoa Glutamine and serine-rich protein 1 Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}.
Q3T8J9 GON4L S2104 ochoa GON-4-like protein (GON-4 homolog) Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}.
Q5T6F2 UBAP2 S956 ochoa Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}.
Q5TGY3 AHDC1 S868 ochoa Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}.
Q63HR2 TNS2 S832 ochoa Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}.
Q6PGQ7 BORA S325 ochoa|psp Protein aurora borealis (HsBora) Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.
Q6ZNC4 ZNF704 S264 ochoa Zinc finger protein 704 Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}.
Q6ZRV2 FAM83H S523 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q6ZRV2 FAM83H S1068 ochoa Protein FAM83H May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}.
Q6ZVH7 ESPNL S372 ochoa Espin-like protein Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.
Q86SQ0 PHLDB2 S934 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86TP1 PRUNE1 S414 ochoa Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.
Q86X27 RALGPS2 S296 ochoa Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q8IWC1 MAP7D3 S533 ochoa MAP7 domain-containing protein 3 Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}.
Q8IY92 SLX4 S1354 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IZD0 SAMD14 S173 ochoa Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) None
Q8IZW8 TNS4 S416 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8N1W1 ARHGEF28 S720 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N3D4 EHBP1L1 S310 ochoa EH domain-binding protein 1-like protein 1 May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.
Q8N3F8 MICALL1 S589 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8NBV4 PLPP7 S43 ochoa Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}.
Q8NEA6 GLIS3 S623 ochoa Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}.
Q8TAP9 MPLKIP S47 ochoa M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
Q8TAQ2 SMARCC2 S555 ochoa SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q8TDM6 DLG5 S866 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TEH3 DENND1A S567 ochoa DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.
Q8TF72 SHROOM3 S754 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q92570 NR4A3 S387 ochoa Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}.
Q96D71 REPS1 S127 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96EY1 DNAJA3 S23 ochoa DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog) Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Q96FS4 SIPA1 S74 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q96JM3 CHAMP1 S459 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96MU7 YTHDC1 S146 ochoa YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}.
Q96PK6 RBM14 S215 ochoa RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}.
Q96PM9 ZNF385A S160 ochoa Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}.
Q96T58 SPEN S324 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99501 GAS2L1 S486 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99700 ATXN2 S530 ochoa Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}.
Q99856 ARID3A S371 ochoa AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}.
Q9BQC3 DPH2 S431 ochoa 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}.
Q9BV36 MLPH S162 ochoa Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}.
Q9BW04 SARG S453 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BXK5 BCL2L13 S429 ochoa Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) May promote the activation of caspase-3 and apoptosis.
Q9BY89 KIAA1671 S465 ochoa Uncharacterized protein KIAA1671 None
Q9GZN2 TGIF2 S153 ochoa Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}.
Q9GZP1 NRSN2 S178 ochoa Neurensin-2 May play a role in maintenance and/or transport of vesicles.
Q9H0H5 RACGAP1 S600 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H4L4 SENP3 S188 ochoa Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H6U6 BCAS3 S706 ochoa BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9H9J4 USP42 S863 ochoa Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9NRA0 SPHK2 S421 psp Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Q9NSI6 BRWD1 S696 ochoa Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Q9NTJ3 SMC4 S27 ochoa Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Q9NZJ0 DTL S520 ochoa Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}.
Q9NZN8 CNOT2 S120 ochoa CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Q9P1Y5 CAMSAP3 S685 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P202 WHRN S245 ochoa Whirlin (Autosomal recessive deafness type 31 protein) Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}.
Q9UBC2 EPS15L1 S362 ochoa Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.
Q9UJX2 CDC23 S576 ochoa Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9UMS6 SYNPO2 S820 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UN30 SCML1 S150 ochoa Sex comb on midleg-like protein 1 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}.
Q9UPW6 SATB2 S20 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9UQB8 BAIAP2 S475 ochoa BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Q9Y450 HBS1L S229 ochoa HBS1-like protein (EC 3.6.5.-) (ERFS) GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}.
Q9Y4B5 MTCL1 S1319 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y4F5 CEP170B S718 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
P11586 MTHFD1 S323 Sugiyama C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}.
Download
reactome_id name p -log10_p
R-HSA-383280 Nuclear Receptor transcription pathway 1.777054e-10 9.750
R-HSA-212436 Generic Transcription Pathway 9.110113e-07 6.040
R-HSA-73857 RNA Polymerase II Transcription 2.011324e-06 5.697
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.756355e-05 4.755
R-HSA-74160 Gene expression (Transcription) 1.791015e-05 4.747
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 6.229066e-04 3.206
R-HSA-8878171 Transcriptional regulation by RUNX1 9.734808e-04 3.012
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 1.470455e-03 2.833
R-HSA-429947 Deadenylation of mRNA 1.981691e-03 2.703
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.186851e-03 2.660
R-HSA-429914 Deadenylation-dependent mRNA decay 2.308042e-03 2.637
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 2.013919e-03 2.696
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 3.613576e-03 2.442
R-HSA-2025928 Calcineurin activates NFAT 4.436138e-03 2.353
R-HSA-201681 TCF dependent signaling in response to WNT 6.436732e-03 2.191
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 7.302081e-03 2.137
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 8.670594e-03 2.062
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 9.669457e-03 2.015
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1.295457e-02 1.888
R-HSA-9856651 MITF-M-dependent gene expression 1.247111e-02 1.904
R-HSA-9730414 MITF-M-regulated melanocyte development 1.239482e-02 1.907
R-HSA-5339700 Signaling by TCF7L2 mutants 2.411221e-02 1.618
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 3.986556e-02 1.399
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 3.986556e-02 1.399
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 3.986556e-02 1.399
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 4.764734e-02 1.322
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 5.536653e-02 1.257
R-HSA-5340588 Signaling by RNF43 mutants 6.302363e-02 1.200
R-HSA-8951430 RUNX3 regulates WNT signaling 7.815351e-02 1.107
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 7.815351e-02 1.107
R-HSA-112412 SOS-mediated signalling 7.815351e-02 1.107
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 9.304093e-02 1.031
R-HSA-201688 WNT mediated activation of DVL 9.304093e-02 1.031
R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.149258e-01 0.940
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.221037e-01 0.913
R-HSA-179812 GRB2 events in EGFR signaling 1.221037e-01 0.913
R-HSA-170660 Adenylate cyclase activating pathway 1.292238e-01 0.889
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.292238e-01 0.889
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.362866e-01 0.866
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.432925e-01 0.844
R-HSA-170670 Adenylate cyclase inhibitory pathway 1.432925e-01 0.844
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.432925e-01 0.844
R-HSA-176412 Phosphorylation of the APC/C 1.502420e-01 0.823
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.502420e-01 0.823
R-HSA-1963640 GRB2 events in ERBB2 signaling 1.571356e-01 0.804
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 1.571356e-01 0.804
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.774852e-01 0.751
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.841594e-01 0.735
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.907799e-01 0.719
R-HSA-72649 Translation initiation complex formation 9.124246e-02 1.040
R-HSA-72702 Ribosomal scanning and start codon recognition 9.623297e-02 1.017
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.528953e-02 1.123
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.780577e-01 0.556
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.958620e-01 0.708
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.988052e-01 0.702
R-HSA-72689 Formation of a pool of free 40S subunits 2.135970e-01 0.670
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.674729e-01 0.573
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.674729e-01 0.573
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 1.292238e-01 0.889
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 1.012997e-01 0.994
R-HSA-77595 Processing of Intronless Pre-mRNAs 1.571356e-01 0.804
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 1.067602e-01 0.972
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 1.067602e-01 0.972
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 1.067602e-01 0.972
R-HSA-191650 Regulation of gap junction activity 4.764734e-02 1.322
R-HSA-8951936 RUNX3 regulates p14-ARF 1.221037e-01 0.913
R-HSA-9932451 SWI/SNF chromatin remodelers 2.230910e-01 0.652
R-HSA-9932444 ATP-dependent chromatin remodelers 2.230910e-01 0.652
R-HSA-72737 Cap-dependent Translation Initiation 9.044456e-02 1.044
R-HSA-8941856 RUNX3 regulates NOTCH signaling 1.221037e-01 0.913
R-HSA-4641265 Repression of WNT target genes 1.221037e-01 0.913
R-HSA-72613 Eukaryotic Translation Initiation 9.044456e-02 1.044
R-HSA-8849473 PTK6 Expression 7.815351e-02 1.107
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 3.519056e-02 1.454
R-HSA-9664420 Killing mechanisms 1.502420e-01 0.823
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 1.502420e-01 0.823
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.639737e-01 0.785
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.528953e-02 1.123
R-HSA-2424491 DAP12 signaling 2.541215e-01 0.595
R-HSA-2871809 FCERI mediated Ca+2 mobilization 8.887516e-02 1.051
R-HSA-5619507 Activation of HOX genes during differentiation 6.957464e-02 1.158
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 6.957464e-02 1.158
R-HSA-69560 Transcriptional activation of p53 responsive genes 4.764734e-02 1.322
R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 4.764734e-02 1.322
R-HSA-8851805 MET activates RAS signaling 1.221037e-01 0.913
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 4.065916e-02 1.391
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 5.454436e-02 1.263
R-HSA-8856828 Clathrin-mediated endocytosis 1.443327e-01 0.841
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.725463e-01 0.763
R-HSA-74749 Signal attenuation 1.003949e-01 0.998
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.149258e-01 0.940
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 2.356540e-01 0.628
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 2.780577e-01 0.556
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 2.165687e-01 0.664
R-HSA-8875513 MET interacts with TNS proteins 3.986556e-02 1.399
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 4.764734e-02 1.322
R-HSA-9034864 Activated NTRK3 signals through RAS 1.076897e-01 0.968
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 1.149258e-01 0.940
R-HSA-428540 Activation of RAC1 1.149258e-01 0.940
R-HSA-9026519 Activated NTRK2 signals through RAS 1.149258e-01 0.940
R-HSA-180336 SHC1 events in EGFR signaling 1.432925e-01 0.844
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.502420e-01 0.823
R-HSA-1250347 SHC1 events in ERBB4 signaling 1.571356e-01 0.804
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.571356e-01 0.804
R-HSA-4641263 Regulation of FZD by ubiquitination 1.639737e-01 0.785
R-HSA-164378 PKA activation in glucagon signalling 1.707568e-01 0.768
R-HSA-5654704 SHC-mediated cascade:FGFR3 1.907799e-01 0.719
R-HSA-5654719 SHC-mediated cascade:FGFR4 1.973471e-01 0.705
R-HSA-5654688 SHC-mediated cascade:FGFR1 2.167329e-01 0.664
R-HSA-5654699 SHC-mediated cascade:FGFR2 2.356540e-01 0.628
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 2.955081e-01 0.529
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 1.655347e-01 0.781
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.221037e-01 0.913
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 1.841594e-01 0.735
R-HSA-2428933 SHC-related events triggered by IGF1R 1.221037e-01 0.913
R-HSA-75067 Processing of Capped Intronless Pre-mRNA 2.167329e-01 0.664
R-HSA-8878159 Transcriptional regulation by RUNX3 2.195441e-01 0.658
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 2.721461e-01 0.565
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 2.706190e-01 0.568
R-HSA-195721 Signaling by WNT 4.634010e-02 1.334
R-HSA-2179392 EGFR Transactivation by Gastrin 1.003949e-01 0.998
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.571356e-01 0.804
R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.707568e-01 0.768
R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.774852e-01 0.751
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 2.167329e-01 0.664
R-HSA-1250196 SHC1 events in ERBB2 signaling 2.541215e-01 0.595
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 2.541215e-01 0.595
R-HSA-163359 Glucagon signaling in metabolic regulation 2.780577e-01 0.556
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 2.167329e-01 0.664
R-HSA-4086400 PCP/CE pathway 1.553922e-01 0.809
R-HSA-9818749 Regulation of NFE2L2 gene expression 7.061912e-02 1.151
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 1.221037e-01 0.913
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 1.432925e-01 0.844
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 1.432925e-01 0.844
R-HSA-3858494 Beta-catenin independent WNT signaling 1.295337e-01 0.888
R-HSA-918233 TRAF3-dependent IRF activation pathway 1.571356e-01 0.804
R-HSA-182971 EGFR downregulation 2.601784e-01 0.585
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.707568e-01 0.768
R-HSA-4086398 Ca2+ pathway 1.413725e-01 0.850
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 9.304093e-02 1.031
R-HSA-5358493 Synthesis of diphthamide-EEF2 1.149258e-01 0.940
R-HSA-9839394 TGFBR3 expression 2.678520e-02 1.572
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.221037e-01 0.913
R-HSA-6811555 PI5P Regulates TP53 Acetylation 1.292238e-01 0.889
R-HSA-9027284 Erythropoietin activates RAS 1.432925e-01 0.844
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 1.502420e-01 0.823
R-HSA-163615 PKA activation 1.707568e-01 0.768
R-HSA-909733 Interferon alpha/beta signaling 2.824901e-01 0.549
R-HSA-9664565 Signaling by ERBB2 KD Mutants 2.480154e-01 0.606
R-HSA-8853884 Transcriptional Regulation by VENTX 5.877837e-02 1.231
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 1.386029e-01 0.858
R-HSA-4839726 Chromatin organization 1.770120e-01 0.752
R-HSA-1227990 Signaling by ERBB2 in Cancer 2.541215e-01 0.595
R-HSA-9768777 Regulation of NPAS4 gene transcription 9.304093e-02 1.031
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1.221037e-01 0.913
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.639737e-01 0.785
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.639737e-01 0.785
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.774852e-01 0.751
R-HSA-5654706 FRS-mediated FGFR3 signaling 1.973471e-01 0.705
R-HSA-5654712 FRS-mediated FGFR4 signaling 2.038613e-01 0.691
R-HSA-5654693 FRS-mediated FGFR1 signaling 2.230910e-01 0.652
R-HSA-5654700 FRS-mediated FGFR2 signaling 2.418597e-01 0.616
R-HSA-177929 Signaling by EGFR 9.623297e-02 1.017
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 6.983383e-02 1.156
R-HSA-9816359 Maternal to zygotic transition (MZT) 2.621809e-02 1.581
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 5.042487e-02 1.297
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 2.839216e-01 0.547
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 5.536653e-02 1.257
R-HSA-9614657 FOXO-mediated transcription of cell death genes 1.707568e-01 0.768
R-HSA-167044 Signalling to RAS 1.907799e-01 0.719
R-HSA-9675126 Diseases of mitotic cell cycle 2.661864e-01 0.575
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 6.817808e-02 1.166
R-HSA-9930044 Nuclear RNA decay 2.721461e-01 0.565
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 1.734644e-01 0.761
R-HSA-1266695 Interleukin-7 signaling 2.678520e-02 1.572
R-HSA-1643713 Signaling by EGFR in Cancer 2.293979e-01 0.639
R-HSA-9768759 Regulation of NPAS4 gene expression 1.639737e-01 0.785
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 2.038613e-01 0.691
R-HSA-5621575 CD209 (DC-SIGN) signaling 2.167329e-01 0.664
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.907799e-01 0.719
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.907799e-01 0.719
R-HSA-5654708 Downstream signaling of activated FGFR3 2.480154e-01 0.606
R-HSA-5654716 Downstream signaling of activated FGFR4 2.541215e-01 0.595
R-HSA-5654696 Downstream signaling of activated FGFR2 2.897383e-01 0.538
R-HSA-5689877 Josephin domain DUBs 1.003949e-01 0.998
R-HSA-9675151 Disorders of Developmental Biology 1.571356e-01 0.804
R-HSA-9671555 Signaling by PDGFR in disease 1.973471e-01 0.705
R-HSA-912526 Interleukin receptor SHC signaling 2.103231e-01 0.677
R-HSA-5689901 Metalloprotease DUBs 2.293979e-01 0.639
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 1.222567e-01 0.913
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 2.721461e-01 0.565
R-HSA-5654687 Downstream signaling of activated FGFR1 2.897383e-01 0.538
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 1.610734e-01 0.793
R-HSA-9823730 Formation of definitive endoderm 1.841594e-01 0.735
R-HSA-5693537 Resolution of D-Loop Structures 2.780577e-01 0.556
R-HSA-9659379 Sensory processing of sound 1.582279e-01 0.801
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1.292238e-01 0.889
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 1.432925e-01 0.844
R-HSA-210993 Tie2 Signaling 1.707568e-01 0.768
R-HSA-392517 Rap1 signalling 1.774852e-01 0.751
R-HSA-111931 PKA-mediated phosphorylation of CREB 1.907799e-01 0.719
R-HSA-193648 NRAGE signals death through JNK 9.623297e-02 1.017
R-HSA-525793 Myogenesis 2.293979e-01 0.639
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.276511e-01 0.894
R-HSA-6806834 Signaling by MET 1.610734e-01 0.793
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 2.541215e-01 0.595
R-HSA-5655291 Signaling by FGFR4 in disease 1.362866e-01 0.866
R-HSA-156711 Polo-like kinase mediated events 1.707568e-01 0.768
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.331009e-01 0.876
R-HSA-8953854 Metabolism of RNA 2.624319e-01 0.581
R-HSA-1433559 Regulation of KIT signaling 1.362866e-01 0.866
R-HSA-4791275 Signaling by WNT in cancer 3.880242e-02 1.411
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 5.042487e-02 1.297
R-HSA-9907900 Proteasome assembly 6.757124e-02 1.170
R-HSA-166208 mTORC1-mediated signalling 2.038613e-01 0.691
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 9.623297e-02 1.017
R-HSA-186763 Downstream signal transduction 2.601784e-01 0.585
R-HSA-5633007 Regulation of TP53 Activity 1.774696e-01 0.751
R-HSA-9707616 Heme signaling 1.116474e-01 0.952
R-HSA-9819196 Zygotic genome activation (ZGA) 1.907799e-01 0.719
R-HSA-69275 G2/M Transition 2.337114e-01 0.631
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 1.907799e-01 0.719
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.293979e-01 0.639
R-HSA-453274 Mitotic G2-G2/M phases 2.380076e-01 0.623
R-HSA-9614085 FOXO-mediated transcription 2.255054e-01 0.647
R-HSA-3247509 Chromatin modifying enzymes 1.536464e-01 0.813
R-HSA-9034015 Signaling by NTRK3 (TRKC) 1.973471e-01 0.705
R-HSA-380108 Chemokine receptors bind chemokines 7.912519e-02 1.102
R-HSA-9006115 Signaling by NTRK2 (TRKB) 2.356540e-01 0.628
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 8.562729e-02 1.067
R-HSA-9842663 Signaling by LTK 1.221037e-01 0.913
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 4.642473e-02 1.333
R-HSA-9860931 Response of endothelial cells to shear stress 2.404579e-01 0.619
R-HSA-5655332 Signaling by FGFR3 in disease 2.356540e-01 0.628
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 1.432925e-01 0.844
R-HSA-1980145 Signaling by NOTCH2 2.839216e-01 0.547
R-HSA-9839373 Signaling by TGFBR3 7.212105e-02 1.142
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 2.734812e-01 0.563
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 2.167329e-01 0.664
R-HSA-9833109 Evasion by RSV of host interferon responses 2.601784e-01 0.585
R-HSA-8853659 RET signaling 2.955081e-01 0.529
R-HSA-9855142 Cellular responses to mechanical stimuli 2.734812e-01 0.563
R-HSA-3700989 Transcriptional Regulation by TP53 1.026975e-01 0.988
R-HSA-9006335 Signaling by Erythropoietin 2.480154e-01 0.606
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 9.623297e-02 1.017
R-HSA-9669938 Signaling by KIT in disease 2.038613e-01 0.691
R-HSA-9682385 FLT3 signaling in disease 2.955081e-01 0.529
R-HSA-5693538 Homology Directed Repair 2.914903e-01 0.535
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 2.219809e-02 1.654
R-HSA-416482 G alpha (12/13) signalling events 1.553922e-01 0.809
R-HSA-376176 Signaling by ROBO receptors 2.706190e-01 0.568
R-HSA-5688426 Deubiquitination 1.866830e-01 0.729
R-HSA-8941326 RUNX2 regulates bone development 4.840957e-02 1.315
R-HSA-1169408 ISG15 antiviral mechanism 1.469472e-01 0.833
R-HSA-187687 Signalling to ERKs 2.897383e-01 0.538
R-HSA-8983432 Interleukin-15 signaling 1.221037e-01 0.913
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 1.413725e-01 0.850
R-HSA-5621481 C-type lectin receptors (CLRs) 2.020103e-01 0.695
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 2.839216e-01 0.547
R-HSA-8878166 Transcriptional regulation by RUNX2 9.522202e-02 1.021
R-HSA-5607764 CLEC7A (Dectin-1) signaling 2.165687e-01 0.664
R-HSA-111933 Calmodulin induced events 2.955081e-01 0.529
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 2.418597e-01 0.616
R-HSA-354192 Integrin signaling 2.721461e-01 0.565
R-HSA-111997 CaM pathway 2.955081e-01 0.529
R-HSA-9006936 Signaling by TGFB family members 1.774696e-01 0.751
R-HSA-170834 Signaling by TGF-beta Receptor Complex 2.195441e-01 0.658
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 2.661864e-01 0.575
R-HSA-2028269 Signaling by Hippo 1.639737e-01 0.785
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 2.721461e-01 0.565
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.661864e-01 0.575
R-HSA-193704 p75 NTR receptor-mediated signalling 2.255054e-01 0.647
R-HSA-4641258 Degradation of DVL 3.012314e-01 0.521
R-HSA-933541 TRAF6 mediated IRF7 activation 3.012314e-01 0.521
R-HSA-196757 Metabolism of folate and pterines 3.012314e-01 0.521
R-HSA-212165 Epigenetic regulation of gene expression 3.054025e-01 0.515
R-HSA-8875878 MET promotes cell motility 3.069085e-01 0.513
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 3.125399e-01 0.505
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 3.125399e-01 0.505
R-HSA-201556 Signaling by ALK 3.125399e-01 0.505
R-HSA-5696395 Formation of Incision Complex in GG-NER 3.181259e-01 0.497
R-HSA-3371568 Attenuation phase 3.181259e-01 0.497
R-HSA-8941858 Regulation of RUNX3 expression and activity 3.181259e-01 0.497
R-HSA-451927 Interleukin-2 family signaling 3.181259e-01 0.497
R-HSA-3214841 PKMTs methylate histone lysines 3.236668e-01 0.490
R-HSA-9607240 FLT3 Signaling 3.236668e-01 0.490
R-HSA-187037 Signaling by NTRK1 (TRKA) 3.243414e-01 0.489
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 3.291630e-01 0.483
R-HSA-5655302 Signaling by FGFR1 in disease 3.291630e-01 0.483
R-HSA-991365 Activation of GABAB receptors 3.346149e-01 0.475
R-HSA-977444 GABA B receptor activation 3.346149e-01 0.475
R-HSA-400508 Incretin synthesis, secretion, and inactivation 3.346149e-01 0.475
R-HSA-111996 Ca-dependent events 3.346149e-01 0.475
R-HSA-165159 MTOR signalling 3.346149e-01 0.475
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 3.346149e-01 0.475
R-HSA-9843745 Adipogenesis 3.362008e-01 0.473
R-HSA-9909396 Circadian clock 3.391565e-01 0.470
R-HSA-5654743 Signaling by FGFR4 3.400228e-01 0.468
R-HSA-1433557 Signaling by SCF-KIT 3.400228e-01 0.468
R-HSA-2172127 DAP12 interactions 3.453871e-01 0.462
R-HSA-3214858 RMTs methylate histone arginines 3.453871e-01 0.462
R-HSA-3928662 EPHB-mediated forward signaling 3.453871e-01 0.462
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.453871e-01 0.462
R-HSA-162582 Signal Transduction 3.453893e-01 0.462
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 3.507082e-01 0.455
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 3.507082e-01 0.455
R-HSA-6783310 Fanconi Anemia Pathway 3.507082e-01 0.455
R-HSA-5654741 Signaling by FGFR3 3.507082e-01 0.455
R-HSA-76009 Platelet Aggregation (Plug Formation) 3.507082e-01 0.455
R-HSA-1489509 DAG and IP3 signaling 3.507082e-01 0.455
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 3.559863e-01 0.449
R-HSA-2299718 Condensation of Prophase Chromosomes 3.559863e-01 0.449
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.559863e-01 0.449
R-HSA-75153 Apoptotic execution phase 3.559863e-01 0.449
R-HSA-9948299 Ribosome-associated quality control 3.597294e-01 0.444
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.612218e-01 0.442
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 3.664151e-01 0.436
R-HSA-9634597 GPER1 signaling 3.664151e-01 0.436
R-HSA-9031628 NGF-stimulated transcription 3.664151e-01 0.436
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 3.715665e-01 0.430
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 3.715665e-01 0.430
R-HSA-69563 p53-Dependent G1 DNA Damage Response 3.715665e-01 0.430
R-HSA-157858 Gap junction trafficking and regulation 3.715665e-01 0.430
R-HSA-73893 DNA Damage Bypass 3.715665e-01 0.430
R-HSA-73894 DNA Repair 3.734600e-01 0.428
R-HSA-5655253 Signaling by FGFR2 in disease 3.766763e-01 0.424
R-HSA-3371571 HSF1-dependent transactivation 3.817449e-01 0.418
R-HSA-1640170 Cell Cycle 3.822465e-01 0.418
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.867726e-01 0.413
R-HSA-72187 mRNA 3'-end processing 3.867726e-01 0.413
R-HSA-9634815 Transcriptional Regulation by NPAS4 3.867726e-01 0.413
R-HSA-166520 Signaling by NTRKs 3.915708e-01 0.407
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 3.917597e-01 0.407
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 3.917597e-01 0.407
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 3.917597e-01 0.407
R-HSA-432722 Golgi Associated Vesicle Biogenesis 3.917597e-01 0.407
R-HSA-69620 Cell Cycle Checkpoints 3.943478e-01 0.404
R-HSA-9758941 Gastrulation 3.944319e-01 0.404
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 3.967065e-01 0.402
R-HSA-9679191 Potential therapeutics for SARS 3.972869e-01 0.401
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.016135e-01 0.396
R-HSA-418597 G alpha (z) signalling events 4.016135e-01 0.396
R-HSA-9012852 Signaling by NOTCH3 4.016135e-01 0.396
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 4.029786e-01 0.395
R-HSA-5693532 DNA Double-Strand Break Repair 4.058151e-01 0.392
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.064808e-01 0.391
R-HSA-5654736 Signaling by FGFR1 4.064808e-01 0.391
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 4.086451e-01 0.389
R-HSA-73887 Death Receptor Signaling 4.086451e-01 0.389
R-HSA-112399 IRS-mediated signalling 4.113088e-01 0.386
R-HSA-1989781 PPARA activates gene expression 4.114688e-01 0.386
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 4.160979e-01 0.381
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 4.170963e-01 0.380
R-HSA-913531 Interferon Signaling 4.174975e-01 0.379
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 4.208483e-01 0.376
R-HSA-186712 Regulation of beta-cell development 4.208483e-01 0.376
R-HSA-877300 Interferon gamma signaling 4.226971e-01 0.374
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 4.255603e-01 0.371
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 4.255603e-01 0.371
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 4.255603e-01 0.371
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 4.255603e-01 0.371
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 4.255603e-01 0.371
R-HSA-977443 GABA receptor activation 4.255603e-01 0.371
R-HSA-2644603 Signaling by NOTCH1 in Cancer 4.255603e-01 0.371
R-HSA-983189 Kinesins 4.255603e-01 0.371
R-HSA-1227986 Signaling by ERBB2 4.255603e-01 0.371
R-HSA-1660661 Sphingolipid de novo biosynthesis 4.255603e-01 0.371
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 4.255603e-01 0.371
R-HSA-73856 RNA Polymerase II Transcription Termination 4.302343e-01 0.366
R-HSA-2428928 IRS-related events triggered by IGF1R 4.302343e-01 0.366
R-HSA-445717 Aquaporin-mediated transport 4.302343e-01 0.366
R-HSA-8939902 Regulation of RUNX2 expression and activity 4.302343e-01 0.366
R-HSA-9793380 Formation of paraxial mesoderm 4.302343e-01 0.366
R-HSA-112043 PLC beta mediated events 4.302343e-01 0.366
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 4.348705e-01 0.362
R-HSA-6784531 tRNA processing in the nucleus 4.348705e-01 0.362
R-HSA-375165 NCAM signaling for neurite out-growth 4.348705e-01 0.362
R-HSA-9616222 Transcriptional regulation of granulopoiesis 4.348705e-01 0.362
R-HSA-186797 Signaling by PDGF 4.348705e-01 0.362
R-HSA-69615 G1/S DNA Damage Checkpoints 4.394693e-01 0.357
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 4.394693e-01 0.357
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 4.394693e-01 0.357
R-HSA-8848021 Signaling by PTK6 4.394693e-01 0.357
R-HSA-74751 Insulin receptor signalling cascade 4.440310e-01 0.353
R-HSA-2428924 IGF1R signaling cascade 4.440310e-01 0.353
R-HSA-9824443 Parasitic Infection Pathways 4.440498e-01 0.353
R-HSA-9658195 Leishmania infection 4.440498e-01 0.353
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.485558e-01 0.348
R-HSA-1234174 Cellular response to hypoxia 4.485558e-01 0.348
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 4.557075e-01 0.341
R-HSA-112040 G-protein mediated events 4.574961e-01 0.340
R-HSA-5693606 DNA Double Strand Break Response 4.574961e-01 0.340
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.574961e-01 0.340
R-HSA-9909648 Regulation of PD-L1(CD274) expression 4.611054e-01 0.336
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 4.619122e-01 0.335
R-HSA-199991 Membrane Trafficking 4.627933e-01 0.335
R-HSA-5689880 Ub-specific processing proteases 4.637928e-01 0.334
R-HSA-195253 Degradation of beta-catenin by the destruction complex 4.706376e-01 0.327
R-HSA-9764560 Regulation of CDH1 Gene Transcription 4.706376e-01 0.327
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 4.706376e-01 0.327
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 4.749474e-01 0.323
R-HSA-453276 Regulation of mitotic cell cycle 4.749474e-01 0.323
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 4.749474e-01 0.323
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 4.749474e-01 0.323
R-HSA-199992 trans-Golgi Network Vesicle Budding 4.792225e-01 0.319
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 4.792225e-01 0.319
R-HSA-69052 Switching of origins to a post-replicative state 4.834630e-01 0.316
R-HSA-69473 G2/M DNA damage checkpoint 4.876693e-01 0.312
R-HSA-1226099 Signaling by FGFR in disease 4.876693e-01 0.312
R-HSA-9013694 Signaling by NOTCH4 4.876693e-01 0.312
R-HSA-1236394 Signaling by ERBB4 4.876693e-01 0.312
R-HSA-1980143 Signaling by NOTCH1 4.959801e-01 0.305
R-HSA-375276 Peptide ligand-binding receptors 4.980034e-01 0.303
R-HSA-72766 Translation 4.996056e-01 0.301
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 5.000852e-01 0.301
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.031436e-01 0.298
R-HSA-1280218 Adaptive Immune System 5.046945e-01 0.297
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 5.081961e-01 0.294
R-HSA-5654738 Signaling by FGFR2 5.122024e-01 0.291
R-HSA-5693607 Processing of DNA double-strand break ends 5.161764e-01 0.287
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 5.161764e-01 0.287
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 5.201182e-01 0.284
R-HSA-69278 Cell Cycle, Mitotic 5.218734e-01 0.282
R-HSA-9707564 Cytoprotection by HMOX1 5.240281e-01 0.281
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 5.279065e-01 0.277
R-HSA-389948 Co-inhibition by PD-1 5.332695e-01 0.273
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 5.355693e-01 0.271
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 5.393543e-01 0.268
R-HSA-156902 Peptide chain elongation 5.468327e-01 0.262
R-HSA-1236974 ER-Phagosome pathway 5.505266e-01 0.259
R-HSA-373080 Class B/2 (Secretin family receptors) 5.541906e-01 0.256
R-HSA-1912408 Pre-NOTCH Transcription and Translation 5.578250e-01 0.254
R-HSA-156842 Eukaryotic Translation Elongation 5.650057e-01 0.248
R-HSA-74752 Signaling by Insulin receptor 5.650057e-01 0.248
R-HSA-2682334 EPH-Ephrin signaling 5.650057e-01 0.248
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 5.685526e-01 0.245
R-HSA-68867 Assembly of the pre-replicative complex 5.685526e-01 0.245
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 5.755605e-01 0.240
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 5.755605e-01 0.240
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 5.790219e-01 0.237
R-HSA-72764 Eukaryotic Translation Termination 5.790219e-01 0.237
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 5.824553e-01 0.235
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 5.824553e-01 0.235
R-HSA-190236 Signaling by FGFR 5.892391e-01 0.230
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 5.906779e-01 0.229
R-HSA-3214847 HATs acetylate histones 5.925898e-01 0.227
R-HSA-69618 Mitotic Spindle Checkpoint 5.959134e-01 0.225
R-HSA-5610787 Hedgehog 'off' state 5.959134e-01 0.225
R-HSA-2408557 Selenocysteine synthesis 5.992101e-01 0.222
R-HSA-9842860 Regulation of endogenous retroelements 6.024801e-01 0.220
R-HSA-192823 Viral mRNA Translation 6.057236e-01 0.218
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 6.089409e-01 0.215
R-HSA-111885 Opioid Signalling 6.089409e-01 0.215
R-HSA-72312 rRNA processing 6.095577e-01 0.215
R-HSA-9833110 RSV-host interactions 6.121321e-01 0.213
R-HSA-5696398 Nucleotide Excision Repair 6.152975e-01 0.211
R-HSA-9692914 SARS-CoV-1-host interactions 6.184372e-01 0.209
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 6.215515e-01 0.207
R-HSA-69239 Synthesis of DNA 6.215515e-01 0.207
R-HSA-1236975 Antigen processing-Cross presentation 6.246405e-01 0.204
R-HSA-69002 DNA Replication Pre-Initiation 6.277046e-01 0.202
R-HSA-2871796 FCERI mediated MAPK activation 6.367486e-01 0.196
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 6.376803e-01 0.195
R-HSA-1912422 Pre-NOTCH Expression and Processing 6.397145e-01 0.194
R-HSA-1266738 Developmental Biology 6.457327e-01 0.190
R-HSA-4420097 VEGFA-VEGFR2 Pathway 6.513399e-01 0.186
R-HSA-9007101 Rab regulation of trafficking 6.570122e-01 0.182
R-HSA-1592230 Mitochondrial biogenesis 6.570122e-01 0.182
R-HSA-2980736 Peptide hormone metabolism 6.570122e-01 0.182
R-HSA-388841 Regulation of T cell activation by CD28 family 6.588937e-01 0.181
R-HSA-68875 Mitotic Prophase 6.653494e-01 0.177
R-HSA-9759194 Nuclear events mediated by NFE2L2 6.680836e-01 0.175
R-HSA-3371556 Cellular response to heat stress 6.680836e-01 0.175
R-HSA-5653656 Vesicle-mediated transport 6.717392e-01 0.173
R-HSA-2132295 MHC class II antigen presentation 6.734855e-01 0.172
R-HSA-422475 Axon guidance 6.797000e-01 0.168
R-HSA-194138 Signaling by VEGF 6.814252e-01 0.167
R-HSA-9711123 Cellular response to chemical stress 6.816474e-01 0.166
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 6.840290e-01 0.165
R-HSA-69481 G2/M Checkpoints 6.866116e-01 0.163
R-HSA-9679506 SARS-CoV Infections 6.929391e-01 0.159
R-HSA-8856688 Golgi-to-ER retrograde transport 7.016734e-01 0.154
R-HSA-9018519 Estrogen-dependent gene expression 7.136744e-01 0.146
R-HSA-163685 Integration of energy metabolism 7.136744e-01 0.146
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 7.160165e-01 0.145
R-HSA-5358351 Signaling by Hedgehog 7.183396e-01 0.144
R-HSA-9664407 Parasite infection 7.229293e-01 0.141
R-HSA-9664422 FCGR3A-mediated phagocytosis 7.229293e-01 0.141
R-HSA-9664417 Leishmania phagocytosis 7.229293e-01 0.141
R-HSA-372790 Signaling by GPCR 7.244983e-01 0.140
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 7.251962e-01 0.140
R-HSA-9675108 Nervous system development 7.267485e-01 0.139
R-HSA-69242 S Phase 7.426814e-01 0.129
R-HSA-9755511 KEAP1-NFE2L2 pathway 7.489498e-01 0.126
R-HSA-9609507 Protein localization 7.530443e-01 0.123
R-HSA-69306 DNA Replication 7.530443e-01 0.123
R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.570725e-01 0.121
R-HSA-9711097 Cellular response to starvation 7.629928e-01 0.117
R-HSA-109581 Apoptosis 7.706644e-01 0.113
R-HSA-2467813 Separation of Sister Chromatids 7.744073e-01 0.111
R-HSA-2408522 Selenoamino acid metabolism 7.744073e-01 0.111
R-HSA-72306 tRNA processing 7.870364e-01 0.104
R-HSA-418555 G alpha (s) signalling events 7.887823e-01 0.103
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 7.922316e-01 0.101
R-HSA-9664433 Leishmania parasite growth and survival 7.922316e-01 0.101
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 7.922316e-01 0.101
R-HSA-9764265 Regulation of CDH1 Expression and Function 7.922316e-01 0.101
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 7.939353e-01 0.100
R-HSA-1280215 Cytokine Signaling in Immune system 7.942829e-01 0.100
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 7.956251e-01 0.099
R-HSA-9678108 SARS-CoV-1 Infection 7.956251e-01 0.099
R-HSA-168255 Influenza Infection 8.022478e-01 0.096
R-HSA-2559583 Cellular Senescence 8.038699e-01 0.095
R-HSA-597592 Post-translational protein modification 8.157771e-01 0.088
R-HSA-68877 Mitotic Prometaphase 8.237939e-01 0.084
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 8.280986e-01 0.082
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 8.336763e-01 0.079
R-HSA-428157 Sphingolipid metabolism 8.350424e-01 0.078
R-HSA-5357801 Programmed Cell Death 8.417078e-01 0.075
R-HSA-68886 M Phase 8.423075e-01 0.075
R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.433110e-01 0.074
R-HSA-8953897 Cellular responses to stimuli 8.439057e-01 0.074
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 8.505925e-01 0.070
R-HSA-392499 Metabolism of proteins 8.521624e-01 0.069
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 8.539766e-01 0.069
R-HSA-68882 Mitotic Anaphase 8.554454e-01 0.068
R-HSA-2555396 Mitotic Metaphase and Anaphase 8.566340e-01 0.067
R-HSA-418990 Adherens junctions interactions 8.578129e-01 0.067
R-HSA-8951664 Neddylation 8.612922e-01 0.065
R-HSA-418594 G alpha (i) signalling events 8.657324e-01 0.063
R-HSA-9705683 SARS-CoV-2-host interactions 8.690853e-01 0.061
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.712310e-01 0.060
R-HSA-500792 GPCR ligand binding 8.770243e-01 0.057
R-HSA-8939211 ESR-mediated signaling 8.784697e-01 0.056
R-HSA-202733 Cell surface interactions at the vascular wall 8.784697e-01 0.056
R-HSA-157118 Signaling by NOTCH 8.814470e-01 0.055
R-HSA-421270 Cell-cell junction organization 8.917576e-01 0.050
R-HSA-388396 GPCR downstream signalling 8.919478e-01 0.050
R-HSA-449147 Signaling by Interleukins 9.000073e-01 0.046
R-HSA-416476 G alpha (q) signalling events 9.028008e-01 0.044
R-HSA-76002 Platelet activation, signaling and aggregation 9.105281e-01 0.041
R-HSA-446728 Cell junction organization 9.134455e-01 0.039
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 9.141600e-01 0.039
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.162684e-01 0.038
R-HSA-5673001 RAF/MAP kinase cascade 9.209904e-01 0.036
R-HSA-5684996 MAPK1/MAPK3 signaling 9.254481e-01 0.034
R-HSA-2262752 Cellular responses to stress 9.300616e-01 0.031
R-HSA-1500931 Cell-Cell communication 9.368551e-01 0.028
R-HSA-1852241 Organelle biogenesis and maintenance 9.389195e-01 0.027
R-HSA-112315 Transmission across Chemical Synapses 9.404236e-01 0.027
R-HSA-8957322 Metabolism of steroids 9.409168e-01 0.026
R-HSA-9006925 Intracellular signaling by second messengers 9.491321e-01 0.023
R-HSA-5683057 MAPK family signaling cascades 9.512056e-01 0.022
R-HSA-9694516 SARS-CoV-2 Infection 9.520114e-01 0.021
R-HSA-9006931 Signaling by Nuclear Receptors 9.572936e-01 0.019
R-HSA-168256 Immune System 9.573555e-01 0.019
R-HSA-196854 Metabolism of vitamins and cofactors 9.576480e-01 0.019
R-HSA-9824446 Viral Infection Pathways 9.607254e-01 0.017
R-HSA-5663205 Infectious disease 9.735991e-01 0.012
R-HSA-112316 Neuronal System 9.823978e-01 0.008
R-HSA-168249 Innate Immune System 9.876192e-01 0.005
R-HSA-109582 Hemostasis 9.904586e-01 0.004
R-HSA-71291 Metabolism of amino acids and derivatives 9.950298e-01 0.002
R-HSA-1643685 Disease 9.980573e-01 0.001
R-HSA-9709957 Sensory Perception 9.997149e-01 0.000
R-HSA-556833 Metabolism of lipids 9.997335e-01 0.000
R-HSA-382551 Transport of small molecules 9.997787e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.853 0.452 1 0.847
SRPK1SRPK1 0.850 0.482 -3 0.845
HIPK4HIPK4 0.848 0.516 1 0.853
HIPK2HIPK2 0.844 0.563 1 0.848
PIM3PIM3 0.841 0.340 -3 0.866
KISKIS 0.841 0.415 1 0.864
DYRK2DYRK2 0.841 0.536 1 0.879
SRPK2SRPK2 0.839 0.442 -3 0.812
CDKL1CDKL1 0.838 0.432 -3 0.854
CDKL5CDKL5 0.838 0.406 -3 0.854
COTCOT 0.837 0.135 2 0.820
CDK18CDK18 0.836 0.468 1 0.838
CLK2CLK2 0.836 0.462 -3 0.844
NLKNLK 0.835 0.427 1 0.874
ICKICK 0.834 0.465 -3 0.857
HIPK1HIPK1 0.833 0.545 1 0.881
NDR2NDR2 0.832 0.214 -3 0.841
PIM1PIM1 0.832 0.345 -3 0.853
CDK7CDK7 0.831 0.433 1 0.868
CDK5CDK5 0.830 0.435 1 0.874
CDK1CDK1 0.829 0.431 1 0.853
MOSMOS 0.829 0.185 1 0.782
DYRK1ADYRK1A 0.829 0.535 1 0.874
DYRK4DYRK4 0.829 0.505 1 0.855
CDK19CDK19 0.828 0.412 1 0.828
CDC7CDC7 0.827 0.094 1 0.747
CLK1CLK1 0.827 0.439 -3 0.807
CDK8CDK8 0.827 0.399 1 0.843
SRPK3SRPK3 0.827 0.379 -3 0.824
CLK4CLK4 0.827 0.415 -3 0.832
RSK2RSK2 0.827 0.304 -3 0.848
JNK2JNK2 0.827 0.467 1 0.844
MTORMTOR 0.827 0.132 1 0.734
CDK17CDK17 0.826 0.443 1 0.809
PRKD1PRKD1 0.826 0.276 -3 0.812
P38GP38G 0.825 0.451 1 0.809
SKMLCKSKMLCK 0.825 0.239 -2 0.839
P90RSKP90RSK 0.824 0.307 -3 0.851
PKN3PKN3 0.824 0.236 -3 0.832
PRKD2PRKD2 0.824 0.297 -3 0.818
RSK3RSK3 0.824 0.292 -3 0.835
ERK5ERK5 0.824 0.221 1 0.808
MAKMAK 0.823 0.531 -2 0.726
NUAK2NUAK2 0.823 0.258 -3 0.843
CAMK1BCAMK1B 0.823 0.246 -3 0.831
CDK3CDK3 0.823 0.409 1 0.825
JNK3JNK3 0.822 0.441 1 0.857
P38BP38B 0.822 0.440 1 0.838
DYRK1BDYRK1B 0.822 0.492 1 0.861
NDR1NDR1 0.821 0.186 -3 0.837
HIPK3HIPK3 0.821 0.512 1 0.867
CDK14CDK14 0.821 0.464 1 0.858
DYRK3DYRK3 0.821 0.479 1 0.871
CDK13CDK13 0.820 0.394 1 0.857
ERK1ERK1 0.820 0.420 1 0.837
PKCDPKCD 0.819 0.210 2 0.754
P38AP38A 0.819 0.421 1 0.864
MAPKAPK2MAPKAPK2 0.819 0.276 -3 0.819
PRPKPRPK 0.818 -0.039 -1 0.800
CDK16CDK16 0.818 0.428 1 0.821
CDK10CDK10 0.818 0.448 1 0.854
CDK12CDK12 0.817 0.409 1 0.842
ATRATR 0.817 0.065 1 0.717
RSK4RSK4 0.817 0.290 -3 0.853
PKN2PKN2 0.817 0.180 -3 0.801
PKACBPKACB 0.816 0.248 -2 0.656
MARK4MARK4 0.816 0.149 4 0.811
CAMLCKCAMLCK 0.816 0.198 -2 0.808
AMPKA1AMPKA1 0.816 0.206 -3 0.823
RAF1RAF1 0.815 -0.015 1 0.700
DSTYKDSTYK 0.815 -0.027 2 0.841
DAPK2DAPK2 0.815 0.230 -3 0.822
CDK9CDK9 0.815 0.397 1 0.859
P70S6KBP70S6KB 0.815 0.238 -3 0.832
AMPKA2AMPKA2 0.814 0.238 -3 0.824
AKT2AKT2 0.814 0.330 -3 0.804
AURCAURC 0.814 0.140 -2 0.624
MAPKAPK3MAPKAPK3 0.814 0.234 -3 0.805
LATS2LATS2 0.814 0.124 -5 0.721
PRKXPRKX 0.814 0.270 -3 0.800
NIKNIK 0.814 0.179 -3 0.801
PKACGPKACG 0.813 0.173 -2 0.736
IKKBIKKB 0.812 -0.069 -2 0.708
P38DP38D 0.812 0.425 1 0.816
GCN2GCN2 0.812 -0.127 2 0.749
PKCBPKCB 0.812 0.199 2 0.714
QSKQSK 0.812 0.228 4 0.805
WNK1WNK1 0.812 0.083 -2 0.846
TBK1TBK1 0.811 -0.075 1 0.592
CDK2CDK2 0.811 0.308 1 0.870
BMPR2BMPR2 0.811 -0.101 -2 0.845
PRKD3PRKD3 0.811 0.287 -3 0.791
MSK2MSK2 0.811 0.237 -3 0.824
NUAK1NUAK1 0.811 0.227 -3 0.820
TGFBR2TGFBR2 0.810 0.018 -2 0.782
GRK1GRK1 0.810 0.067 -2 0.795
MST4MST4 0.810 0.050 2 0.796
LATS1LATS1 0.810 0.192 -3 0.847
PDHK4PDHK4 0.810 -0.178 1 0.734
CAMK2DCAMK2D 0.810 0.128 -3 0.798
RIPK3RIPK3 0.809 -0.006 3 0.792
MSK1MSK1 0.809 0.239 -3 0.823
ERK2ERK2 0.809 0.381 1 0.852
CAMK2ACAMK2A 0.809 0.187 2 0.755
PIM2PIM2 0.809 0.308 -3 0.822
PKCAPKCA 0.809 0.169 2 0.703
NEK6NEK6 0.809 -0.022 -2 0.836
TSSK1TSSK1 0.809 0.171 -3 0.832
SIKSIK 0.808 0.251 -3 0.791
PKCGPKCG 0.808 0.149 2 0.715
BMPR1BBMPR1B 0.808 0.105 1 0.699
SGK3SGK3 0.807 0.269 -3 0.810
IKKEIKKE 0.807 -0.101 1 0.591
MOKMOK 0.807 0.486 1 0.858
CHAK2CHAK2 0.807 0.001 -1 0.764
CAMK2GCAMK2G 0.807 -0.081 2 0.754
CAMK2BCAMK2B 0.806 0.132 2 0.727
ULK2ULK2 0.806 -0.131 2 0.721
MLK1MLK1 0.806 -0.060 2 0.776
MLK2MLK2 0.806 0.037 2 0.775
GRK7GRK7 0.805 0.096 1 0.683
MYLK4MYLK4 0.804 0.185 -2 0.740
PAK1PAK1 0.804 0.109 -2 0.745
NEK7NEK7 0.804 -0.122 -3 0.688
PHKG1PHKG1 0.804 0.151 -3 0.815
MELKMELK 0.803 0.195 -3 0.803
NIM1NIM1 0.803 0.090 3 0.805
MNK2MNK2 0.803 0.097 -2 0.747
MLK3MLK3 0.803 0.041 2 0.723
TSSK2TSSK2 0.803 0.100 -5 0.798
GRK5GRK5 0.803 -0.119 -3 0.730
IKKAIKKA 0.803 -0.042 -2 0.708
PKG2PKG2 0.802 0.167 -2 0.656
PKCZPKCZ 0.802 0.127 2 0.739
FAM20CFAM20C 0.802 0.045 2 0.592
MARK3MARK3 0.801 0.160 4 0.771
PDHK1PDHK1 0.801 -0.197 1 0.704
JNK1JNK1 0.801 0.376 1 0.843
PAK3PAK3 0.801 0.081 -2 0.739
HUNKHUNK 0.801 -0.072 2 0.749
MASTLMASTL 0.800 -0.095 -2 0.789
PRP4PRP4 0.800 0.247 -3 0.663
CAMK4CAMK4 0.800 0.086 -3 0.801
ATMATM 0.800 -0.005 1 0.663
BRSK1BRSK1 0.799 0.173 -3 0.810
QIKQIK 0.799 0.099 -3 0.781
AURBAURB 0.799 0.091 -2 0.621
IRE1IRE1 0.799 0.005 1 0.662
TGFBR1TGFBR1 0.799 0.034 -2 0.801
PKACAPKACA 0.799 0.229 -2 0.603
AKT3AKT3 0.798 0.326 -3 0.779
DLKDLK 0.798 -0.074 1 0.686
PKCHPKCH 0.798 0.125 2 0.690
ALK4ALK4 0.798 0.020 -2 0.815
ANKRD3ANKRD3 0.798 -0.049 1 0.714
BCKDKBCKDK 0.797 -0.122 -1 0.781
MARK2MARK2 0.797 0.137 4 0.738
RIPK1RIPK1 0.797 -0.055 1 0.678
AKT1AKT1 0.797 0.263 -3 0.805
CAMK1GCAMK1G 0.797 0.208 -3 0.811
DCAMKL1DCAMKL1 0.797 0.214 -3 0.810
CDK6CDK6 0.797 0.380 1 0.848
NEK9NEK9 0.797 -0.108 2 0.775
MNK1MNK1 0.797 0.089 -2 0.753
CDK4CDK4 0.796 0.406 1 0.838
WNK3WNK3 0.796 -0.140 1 0.673
ERK7ERK7 0.796 0.195 2 0.576
CHK1CHK1 0.796 0.129 -3 0.805
MLK4MLK4 0.795 -0.010 2 0.703
GRK6GRK6 0.795 -0.094 1 0.714
IRE2IRE2 0.795 0.008 2 0.705
PKRPKR 0.795 0.013 1 0.712
SGK1SGK1 0.794 0.330 -3 0.773
BRSK2BRSK2 0.794 0.102 -3 0.791
PAK6PAK6 0.794 0.086 -2 0.634
ULK1ULK1 0.794 -0.178 -3 0.658
MEK1MEK1 0.793 -0.060 2 0.789
PASKPASK 0.792 0.188 -3 0.855
ACVR2BACVR2B 0.792 -0.004 -2 0.780
PKCTPKCT 0.791 0.152 2 0.691
GRK4GRK4 0.791 -0.137 -2 0.823
TTBK2TTBK2 0.791 -0.139 2 0.648
SMG1SMG1 0.791 -0.024 1 0.671
MARK1MARK1 0.791 0.110 4 0.774
MAPKAPK5MAPKAPK5 0.791 0.175 -3 0.782
AURAAURA 0.791 0.056 -2 0.589
YSK4YSK4 0.791 -0.075 1 0.629
MPSK1MPSK1 0.791 0.148 1 0.699
DNAPKDNAPK 0.790 0.016 1 0.613
ALK2ALK2 0.790 0.007 -2 0.811
VRK2VRK2 0.790 -0.024 1 0.764
GSK3AGSK3A 0.790 0.122 4 0.396
PAK2PAK2 0.790 0.041 -2 0.723
SBKSBK 0.789 0.373 -3 0.739
SMMLCKSMMLCK 0.789 0.182 -3 0.822
CAMK1DCAMK1D 0.789 0.246 -3 0.777
TLK2TLK2 0.789 -0.035 1 0.649
ACVR2AACVR2A 0.788 -0.027 -2 0.758
DAPK3DAPK3 0.788 0.212 -3 0.834
PLK1PLK1 0.788 -0.098 -2 0.772
P70S6KP70S6K 0.787 0.220 -3 0.790
DRAK1DRAK1 0.787 -0.011 1 0.661
DCAMKL2DCAMKL2 0.787 0.132 -3 0.811
PKCEPKCE 0.786 0.181 2 0.704
NEK2NEK2 0.786 -0.063 2 0.764
MST3MST3 0.786 0.057 2 0.800
BMPR1ABMPR1A 0.785 0.033 1 0.679
CHAK1CHAK1 0.785 -0.100 2 0.724
TAO3TAO3 0.784 0.034 1 0.670
PKN1PKN1 0.784 0.231 -3 0.788
CHK2CHK2 0.783 0.287 -3 0.757
PINK1PINK1 0.783 -0.001 1 0.790
SSTKSSTK 0.783 0.090 4 0.782
GRK2GRK2 0.782 -0.054 -2 0.720
PLK4PLK4 0.782 -0.063 2 0.554
SNRKSNRK 0.782 -0.018 2 0.604
CAMK1ACAMK1A 0.782 0.268 -3 0.760
CK1ECK1E 0.782 -0.012 -3 0.486
MEKK2MEKK2 0.782 -0.032 2 0.750
NEK5NEK5 0.781 -0.024 1 0.681
ROCK2ROCK2 0.781 0.231 -3 0.820
DAPK1DAPK1 0.781 0.194 -3 0.831
WNK4WNK4 0.781 -0.002 -2 0.836
PKCIPKCI 0.781 0.100 2 0.716
GSK3BGSK3B 0.780 0.024 4 0.392
MEK5MEK5 0.779 -0.118 2 0.764
IRAK4IRAK4 0.779 -0.037 1 0.655
BRAFBRAF 0.779 -0.053 -4 0.802
PERKPERK 0.779 -0.108 -2 0.802
MRCKBMRCKB 0.778 0.218 -3 0.797
MEKK1MEKK1 0.778 -0.123 1 0.659
ZAKZAK 0.777 -0.119 1 0.623
PDK1PDK1 0.777 0.104 1 0.677
GAKGAK 0.777 0.054 1 0.754
PLK3PLK3 0.777 -0.137 2 0.703
TLK1TLK1 0.777 -0.087 -2 0.832
PHKG2PHKG2 0.776 0.058 -3 0.781
CK1DCK1D 0.776 -0.003 -3 0.438
GCKGCK 0.776 0.058 1 0.667
MRCKAMRCKA 0.776 0.188 -3 0.807
DMPK1DMPK1 0.776 0.245 -3 0.814
MEKK3MEKK3 0.775 -0.150 1 0.663
HRIHRI 0.775 -0.164 -2 0.813
PAK5PAK5 0.775 0.060 -2 0.588
PAK4PAK4 0.775 0.073 -2 0.593
LKB1LKB1 0.773 0.018 -3 0.692
NEK8NEK8 0.772 -0.059 2 0.763
NEK11NEK11 0.771 -0.090 1 0.654
BUB1BUB1 0.771 0.137 -5 0.760
TNIKTNIK 0.771 0.049 3 0.870
HPK1HPK1 0.770 0.044 1 0.658
MST2MST2 0.769 -0.060 1 0.662
TAO2TAO2 0.769 -0.047 2 0.794
CK1A2CK1A2 0.769 -0.033 -3 0.446
CRIKCRIK 0.769 0.271 -3 0.821
GRK3GRK3 0.769 -0.063 -2 0.693
HGKHGK 0.767 -0.006 3 0.874
KHS2KHS2 0.767 0.085 1 0.660
CK1G1CK1G1 0.767 -0.066 -3 0.480
PBKPBK 0.767 0.093 1 0.687
LOKLOK 0.767 0.026 -2 0.731
KHS1KHS1 0.766 0.062 1 0.641
ROCK1ROCK1 0.766 0.206 -3 0.800
MINKMINK 0.766 -0.028 1 0.636
NEK4NEK4 0.766 -0.066 1 0.642
PKG1PKG1 0.765 0.156 -2 0.568
MEKK6MEKK6 0.765 -0.035 1 0.647
MAP3K15MAP3K15 0.765 -0.047 1 0.621
CAMKK1CAMKK1 0.765 -0.168 -2 0.701
LRRK2LRRK2 0.765 -0.000 2 0.784
TAK1TAK1 0.764 -0.047 1 0.668
CAMKK2CAMKK2 0.764 -0.096 -2 0.695
EEF2KEEF2K 0.763 -0.046 3 0.827
SLKSLK 0.762 -0.023 -2 0.685
VRK1VRK1 0.761 -0.077 2 0.772
CK2A2CK2A2 0.760 -0.041 1 0.645
NEK1NEK1 0.760 -0.064 1 0.656
MST1MST1 0.759 -0.088 1 0.640
TTBK1TTBK1 0.758 -0.196 2 0.568
IRAK1IRAK1 0.757 -0.241 -1 0.701
PLK2PLK2 0.756 -0.087 -3 0.662
HASPINHASPIN 0.755 0.038 -1 0.647
PDHK3_TYRPDHK3_TYR 0.755 0.229 4 0.804
TTKTTK 0.754 -0.001 -2 0.801
YSK1YSK1 0.754 -0.050 2 0.754
OSR1OSR1 0.753 -0.030 2 0.748
STK33STK33 0.752 -0.123 2 0.560
MEK2MEK2 0.750 -0.194 2 0.744
CK2A1CK2A1 0.750 -0.052 1 0.629
MYO3BMYO3B 0.747 0.000 2 0.780
BIKEBIKE 0.747 0.026 1 0.667
NEK3NEK3 0.746 -0.106 1 0.615
PDHK4_TYRPDHK4_TYR 0.746 0.084 2 0.813
LIMK2_TYRLIMK2_TYR 0.745 0.184 -3 0.773
MAP2K4_TYRMAP2K4_TYR 0.745 0.100 -1 0.813
TESK1_TYRTESK1_TYR 0.744 0.080 3 0.896
MAP2K6_TYRMAP2K6_TYR 0.744 0.070 -1 0.808
RIPK2RIPK2 0.744 -0.232 1 0.584
MYO3AMYO3A 0.743 -0.037 1 0.646
YANK3YANK3 0.743 -0.049 2 0.368
PKMYT1_TYRPKMYT1_TYR 0.742 0.071 3 0.870
BMPR2_TYRBMPR2_TYR 0.740 0.002 -1 0.792
MAP2K7_TYRMAP2K7_TYR 0.739 -0.058 2 0.789
PDHK1_TYRPDHK1_TYR 0.738 -0.030 -1 0.795
TXKTXK 0.738 0.078 1 0.714
TAO1TAO1 0.738 -0.075 1 0.586
CK1ACK1A 0.737 -0.051 -3 0.364
EPHA6EPHA6 0.737 0.023 -1 0.786
ASK1ASK1 0.737 -0.143 1 0.610
AAK1AAK1 0.735 0.063 1 0.597
ALPHAK3ALPHAK3 0.734 -0.093 -1 0.696
PINK1_TYRPINK1_TYR 0.734 -0.091 1 0.727
RETRET 0.733 -0.050 1 0.674
EPHB4EPHB4 0.733 -0.015 -1 0.774
TYRO3TYRO3 0.732 -0.049 3 0.827
LIMK1_TYRLIMK1_TYR 0.731 -0.041 2 0.785
ROS1ROS1 0.731 -0.033 3 0.806
TNK2TNK2 0.731 0.041 3 0.789
MST1RMST1R 0.730 -0.064 3 0.833
ABL2ABL2 0.730 -0.026 -1 0.749
CSF1RCSF1R 0.728 -0.061 3 0.818
LCKLCK 0.728 0.005 -1 0.748
YES1YES1 0.727 -0.050 -1 0.767
DDR1DDR1 0.727 -0.076 4 0.727
BLKBLK 0.726 0.023 -1 0.748
FGRFGR 0.725 -0.081 1 0.710
ABL1ABL1 0.725 -0.052 -1 0.746
INSRRINSRR 0.724 -0.075 3 0.781
TYK2TYK2 0.724 -0.184 1 0.661
STLK3STLK3 0.724 -0.192 1 0.595
JAK2JAK2 0.723 -0.128 1 0.662
FERFER 0.723 -0.128 1 0.734
JAK3JAK3 0.722 -0.107 1 0.650
ITKITK 0.722 -0.064 -1 0.739
TNNI3K_TYRTNNI3K_TYR 0.721 0.029 1 0.652
FGFR2FGFR2 0.721 -0.070 3 0.827
EPHB3EPHB3 0.721 -0.066 -1 0.766
TNK1TNK1 0.721 -0.007 3 0.804
SRMSSRMS 0.721 -0.084 1 0.711
KDRKDR 0.721 -0.044 3 0.783
EPHA4EPHA4 0.720 -0.068 2 0.713
HCKHCK 0.720 -0.098 -1 0.753
AXLAXL 0.720 -0.063 3 0.815
NEK10_TYRNEK10_TYR 0.720 -0.045 1 0.580
EPHB1EPHB1 0.719 -0.099 1 0.694
TEKTEK 0.719 -0.056 3 0.771
MERTKMERTK 0.718 -0.070 3 0.802
EPHB2EPHB2 0.718 -0.083 -1 0.748
BMXBMX 0.718 -0.050 -1 0.675
FGFR1FGFR1 0.717 -0.073 3 0.796
METMET 0.717 -0.073 3 0.812
KITKIT 0.717 -0.124 3 0.819
DDR2DDR2 0.717 0.034 3 0.772
TECTEC 0.717 -0.065 -1 0.704
PDGFRBPDGFRB 0.716 -0.149 3 0.828
FYNFYN 0.716 -0.025 -1 0.723
JAK1JAK1 0.715 -0.058 1 0.601
FLT3FLT3 0.715 -0.153 3 0.812
EPHA7EPHA7 0.712 -0.074 2 0.710
ALKALK 0.711 -0.110 3 0.742
WEE1_TYRWEE1_TYR 0.711 -0.085 -1 0.704
FGFR3FGFR3 0.710 -0.095 3 0.799
CK1G3CK1G3 0.709 -0.085 -3 0.328
EPHA1EPHA1 0.709 -0.094 3 0.789
LTKLTK 0.709 -0.122 3 0.762
PTK2BPTK2B 0.708 -0.051 -1 0.736
BTKBTK 0.708 -0.205 -1 0.724
FRKFRK 0.708 -0.111 -1 0.762
YANK2YANK2 0.708 -0.095 2 0.392
FLT1FLT1 0.707 -0.138 -1 0.733
PDGFRAPDGFRA 0.707 -0.197 3 0.825
INSRINSR 0.705 -0.147 3 0.761
PTK6PTK6 0.705 -0.184 -1 0.685
EPHA3EPHA3 0.705 -0.144 2 0.679
LYNLYN 0.705 -0.110 3 0.740
NTRK1NTRK1 0.704 -0.213 -1 0.762
NTRK3NTRK3 0.704 -0.129 -1 0.723
ERBB2ERBB2 0.704 -0.174 1 0.633
MATKMATK 0.704 -0.113 -1 0.666
EPHA5EPHA5 0.704 -0.098 2 0.692
PTK2PTK2 0.703 -0.032 -1 0.699
EPHA8EPHA8 0.703 -0.095 -1 0.731
SRCSRC 0.702 -0.092 -1 0.725
NTRK2NTRK2 0.701 -0.212 3 0.783
FLT4FLT4 0.701 -0.181 3 0.779
EGFREGFR 0.697 -0.124 1 0.552
SYKSYK 0.697 -0.061 -1 0.680
CK1G2CK1G2 0.694 -0.077 -3 0.408
CSKCSK 0.694 -0.169 2 0.713
FGFR4FGFR4 0.694 -0.130 -1 0.689
EPHA2EPHA2 0.692 -0.114 -1 0.697
ERBB4ERBB4 0.690 -0.081 1 0.576
MUSKMUSK 0.687 -0.159 1 0.549
IGF1RIGF1R 0.687 -0.171 3 0.702
ZAP70ZAP70 0.685 -0.039 -1 0.629
FESFES 0.675 -0.165 -1 0.656