Motif 196 (n=106)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A087X0R7 | SENP3-EIF4A1 | S118 | ochoa | SENP3-EIF4A1 readthrough (NMD candidate) | None |
A0A0U1RQV5 | None | S26 | ochoa | Eukaryotic translation initiation factor 6 | None |
A1A5D9 | BICDL2 | S330 | ochoa | BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B) | None |
K7ELQ4 | ATF7-NPFF | S311 | ochoa | ATF7-NPFF readthrough | None |
K7EQG2 | None | S30 | ochoa | Uncharacterized protein | None |
O14640 | DVL1 | S126 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
O14686 | KMT2D | S2269 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O15069 | NACAD | S1130 | ochoa | NAC-alpha domain-containing protein 1 | May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
O60237 | PPP1R12B | S412 | ochoa | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. |
O60353 | FZD6 | S683 | ochoa | Frizzled-6 (Fz-6) (hFz6) | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q61089}. |
O94916 | NFAT5 | S1197 | psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
P04150 | NR3C1 | T411 | ochoa | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
P15884 | TCF4 | S340 | ochoa | Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}. |
P26651 | ZFP36 | T257 | ochoa | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
P33240 | CSTF2 | S120 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
P46092 | CCR10 | S329 | ochoa | C-C chemokine receptor type 10 (C-C CKR-10) (CC-CKR-10) (CCR-10) (G-protein coupled receptor 2) | Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. |
P46379 | BAG6 | S985 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
P54253 | ATXN1 | Y247 | ochoa | Ataxin-1 (Spinocerebellar ataxia type 1 protein) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P54254, ECO:0000269|PubMed:21475249}. |
P54725 | RAD23A | S100 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
P55884 | EIF3B | S95 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
P56537 | EIF6 | S174 | ochoa|psp | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)) | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}. |
P61289 | PSME3 | S75 | ochoa | Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. |
P98171 | ARHGAP4 | S906 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
Q00978 | IRF9 | S253 | psp | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000269|PubMed:30143481}. |
Q02086 | SP2 | S187 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
Q04637 | EIF4G1 | S204 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Q07157 | TJP1 | S1579 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q07889 | SOS1 | S1229 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
Q08462 | ADCY2 | S472 | ochoa | Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}. |
Q09472 | EP300 | S106 | psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
Q12888 | TP53BP1 | S1437 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12979 | ABR | S366 | ochoa | Active breakpoint cluster region-related protein | Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity). {ECO:0000250|UniProtKB:Q5SSL4, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:7479768}. |
Q12986 | NFX1 | S1095 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
Q13207 | TBX2 | S386 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
Q13469 | NFATC2 | S808 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
Q13470 | TNK1 | S96 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
Q13492 | PICALM | S474 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
Q14686 | NCOA6 | S1240 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
Q16513 | PKN2 | S622 | ochoa | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
Q2KHR3 | QSER1 | S759 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
Q3T8J9 | GON4L | S2104 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
Q5T6F2 | UBAP2 | S956 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
Q5TGY3 | AHDC1 | S868 | ochoa | Transcription factor Gibbin (AT-hook DNA-binding motif-containing protein 1) | Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237). {ECO:0000269|PubMed:35585237}. |
Q63HR2 | TNS2 | S832 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
Q6PGQ7 | BORA | S325 | ochoa|psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
Q6ZNC4 | ZNF704 | S264 | ochoa | Zinc finger protein 704 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer. {ECO:0000250|UniProtKB:Q9ERQ3}. |
Q6ZRV2 | FAM83H | S523 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
Q6ZRV2 | FAM83H | S1068 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
Q6ZVH7 | ESPNL | S372 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
Q86SQ0 | PHLDB2 | S934 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86TP1 | PRUNE1 | S414 | ochoa | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}. |
Q86X27 | RALGPS2 | S296 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
Q8IWC1 | MAP7D3 | S533 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
Q8IY92 | SLX4 | S1354 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
Q8IZD0 | SAMD14 | S173 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
Q8IZW8 | TNS4 | S416 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
Q8N1W1 | ARHGEF28 | S720 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N3D4 | EHBP1L1 | S310 | ochoa | EH domain-binding protein 1-like protein 1 | May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}. |
Q8N3F8 | MICALL1 | S589 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8NBV4 | PLPP7 | S43 | ochoa | Inactive phospholipid phosphatase 7 (Phosphatidic acid phosphatase type 2 domain-containing protein 3) | Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity). {ECO:0000250}. |
Q8NEA6 | GLIS3 | S623 | ochoa | Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) | Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). {ECO:0000250}. |
Q8TAP9 | MPLKIP | S47 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
Q8TAQ2 | SMARCC2 | S555 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q8TDM6 | DLG5 | S866 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
Q8TEH3 | DENND1A | S567 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
Q8TF72 | SHROOM3 | S754 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
Q92570 | NR4A3 | S387 | ochoa | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) (Translocated in extraskeletal chondrosarcoma) | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (By similarity). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity) (PubMed:20558821). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (PubMed:24022864). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (By similarity). {ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q9QZB6, ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:24022864}. |
Q96D71 | REPS1 | S127 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
Q96EY1 | DNAJA3 | S23 | ochoa | DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog) | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
Q96FS4 | SIPA1 | S74 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
Q96JM3 | CHAMP1 | S459 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96MU7 | YTHDC1 | S146 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
Q96PK6 | RBM14 | S215 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
Q96PM9 | ZNF385A | S160 | ochoa | Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}. |
Q96T58 | SPEN | S324 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99501 | GAS2L1 | S486 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
Q99700 | ATXN2 | S530 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
Q99856 | ARID3A | S371 | ochoa | AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1) | Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}. |
Q9BQC3 | DPH2 | S431 | ochoa | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461, ECO:0000269|PubMed:32576952}. |
Q9BV36 | MLPH | S162 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
Q9BW04 | SARG | S453 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
Q9BXK5 | BCL2L13 | S429 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
Q9BY89 | KIAA1671 | S465 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9GZN2 | TGIF2 | S153 | ochoa | Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) | Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. {ECO:0000269|PubMed:11427533}. |
Q9GZP1 | NRSN2 | S178 | ochoa | Neurensin-2 | May play a role in maintenance and/or transport of vesicles. |
Q9H0H5 | RACGAP1 | S600 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
Q9H4L4 | SENP3 | S188 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
Q9H6U6 | BCAS3 | S706 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
Q9H9J4 | USP42 | S863 | ochoa | Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) | Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}. |
Q9NRA0 | SPHK2 | S421 | psp | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Q9NSI6 | BRWD1 | S696 | ochoa | Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) | May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
Q9NTJ3 | SMC4 | S27 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
Q9NZJ0 | DTL | S520 | ochoa | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480, ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347, ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548, ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:27906959}. |
Q9NZN8 | CNOT2 | S120 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
Q9P1Y5 | CAMSAP3 | S685 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9P202 | WHRN | S245 | ochoa | Whirlin (Autosomal recessive deafness type 31 protein) | Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}. |
Q9UBC2 | EPS15L1 | S362 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
Q9UJX2 | CDC23 | S576 | ochoa | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
Q9UMS6 | SYNPO2 | S820 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UN30 | SCML1 | S150 | ochoa | Sex comb on midleg-like protein 1 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}. |
Q9UPW6 | SATB2 | S20 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
Q9UQB8 | BAIAP2 | S475 | ochoa | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}. |
Q9Y450 | HBS1L | S229 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
Q9Y4B5 | MTCL1 | S1319 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
Q9Y4F5 | CEP170B | S718 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
P11586 | MTHFD1 | S323 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-383280 | Nuclear Receptor transcription pathway | 1.777054e-10 | 9.750 |
R-HSA-212436 | Generic Transcription Pathway | 9.110113e-07 | 6.040 |
R-HSA-73857 | RNA Polymerase II Transcription | 2.011324e-06 | 5.697 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.756355e-05 | 4.755 |
R-HSA-74160 | Gene expression (Transcription) | 1.791015e-05 | 4.747 |
R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 6.229066e-04 | 3.206 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.734808e-04 | 3.012 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.470455e-03 | 2.833 |
R-HSA-429947 | Deadenylation of mRNA | 1.981691e-03 | 2.703 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.186851e-03 | 2.660 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.308042e-03 | 2.637 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 2.013919e-03 | 2.696 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.613576e-03 | 2.442 |
R-HSA-2025928 | Calcineurin activates NFAT | 4.436138e-03 | 2.353 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 6.436732e-03 | 2.191 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.302081e-03 | 2.137 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 8.670594e-03 | 2.062 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 9.669457e-03 | 2.015 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.295457e-02 | 1.888 |
R-HSA-9856651 | MITF-M-dependent gene expression | 1.247111e-02 | 1.904 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.239482e-02 | 1.907 |
R-HSA-5339700 | Signaling by TCF7L2 mutants | 2.411221e-02 | 1.618 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 3.986556e-02 | 1.399 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 3.986556e-02 | 1.399 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 3.986556e-02 | 1.399 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 4.764734e-02 | 1.322 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 5.536653e-02 | 1.257 |
R-HSA-5340588 | Signaling by RNF43 mutants | 6.302363e-02 | 1.200 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 7.815351e-02 | 1.107 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 7.815351e-02 | 1.107 |
R-HSA-112412 | SOS-mediated signalling | 7.815351e-02 | 1.107 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 9.304093e-02 | 1.031 |
R-HSA-201688 | WNT mediated activation of DVL | 9.304093e-02 | 1.031 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.149258e-01 | 0.940 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.221037e-01 | 0.913 |
R-HSA-179812 | GRB2 events in EGFR signaling | 1.221037e-01 | 0.913 |
R-HSA-170660 | Adenylate cyclase activating pathway | 1.292238e-01 | 0.889 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.292238e-01 | 0.889 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.362866e-01 | 0.866 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.432925e-01 | 0.844 |
R-HSA-170670 | Adenylate cyclase inhibitory pathway | 1.432925e-01 | 0.844 |
R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.432925e-01 | 0.844 |
R-HSA-176412 | Phosphorylation of the APC/C | 1.502420e-01 | 0.823 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.502420e-01 | 0.823 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.571356e-01 | 0.804 |
R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.571356e-01 | 0.804 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 1.774852e-01 | 0.751 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.841594e-01 | 0.735 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 1.907799e-01 | 0.719 |
R-HSA-72649 | Translation initiation complex formation | 9.124246e-02 | 1.040 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 9.623297e-02 | 1.017 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 7.528953e-02 | 1.123 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.780577e-01 | 0.556 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.958620e-01 | 0.708 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.988052e-01 | 0.702 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 2.135970e-01 | 0.670 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.674729e-01 | 0.573 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.674729e-01 | 0.573 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.292238e-01 | 0.889 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.012997e-01 | 0.994 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.571356e-01 | 0.804 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.067602e-01 | 0.972 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.067602e-01 | 0.972 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.067602e-01 | 0.972 |
R-HSA-191650 | Regulation of gap junction activity | 4.764734e-02 | 1.322 |
R-HSA-8951936 | RUNX3 regulates p14-ARF | 1.221037e-01 | 0.913 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.230910e-01 | 0.652 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.230910e-01 | 0.652 |
R-HSA-72737 | Cap-dependent Translation Initiation | 9.044456e-02 | 1.044 |
R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.221037e-01 | 0.913 |
R-HSA-4641265 | Repression of WNT target genes | 1.221037e-01 | 0.913 |
R-HSA-72613 | Eukaryotic Translation Initiation | 9.044456e-02 | 1.044 |
R-HSA-8849473 | PTK6 Expression | 7.815351e-02 | 1.107 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 3.519056e-02 | 1.454 |
R-HSA-9664420 | Killing mechanisms | 1.502420e-01 | 0.823 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 1.502420e-01 | 0.823 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.639737e-01 | 0.785 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 7.528953e-02 | 1.123 |
R-HSA-2424491 | DAP12 signaling | 2.541215e-01 | 0.595 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.887516e-02 | 1.051 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 6.957464e-02 | 1.158 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.957464e-02 | 1.158 |
R-HSA-69560 | Transcriptional activation of p53 responsive genes | 4.764734e-02 | 1.322 |
R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 4.764734e-02 | 1.322 |
R-HSA-8851805 | MET activates RAS signaling | 1.221037e-01 | 0.913 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.065916e-02 | 1.391 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.454436e-02 | 1.263 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 1.443327e-01 | 0.841 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.725463e-01 | 0.763 |
R-HSA-74749 | Signal attenuation | 1.003949e-01 | 0.998 |
R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.149258e-01 | 0.940 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 2.356540e-01 | 0.628 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.780577e-01 | 0.556 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.165687e-01 | 0.664 |
R-HSA-8875513 | MET interacts with TNS proteins | 3.986556e-02 | 1.399 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 4.764734e-02 | 1.322 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 1.076897e-01 | 0.968 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.149258e-01 | 0.940 |
R-HSA-428540 | Activation of RAC1 | 1.149258e-01 | 0.940 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 1.149258e-01 | 0.940 |
R-HSA-180336 | SHC1 events in EGFR signaling | 1.432925e-01 | 0.844 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.502420e-01 | 0.823 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.571356e-01 | 0.804 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.571356e-01 | 0.804 |
R-HSA-4641263 | Regulation of FZD by ubiquitination | 1.639737e-01 | 0.785 |
R-HSA-164378 | PKA activation in glucagon signalling | 1.707568e-01 | 0.768 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.907799e-01 | 0.719 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.973471e-01 | 0.705 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 2.167329e-01 | 0.664 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 2.356540e-01 | 0.628 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.955081e-01 | 0.529 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.655347e-01 | 0.781 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.221037e-01 | 0.913 |
R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.841594e-01 | 0.735 |
R-HSA-2428933 | SHC-related events triggered by IGF1R | 1.221037e-01 | 0.913 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.167329e-01 | 0.664 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.195441e-01 | 0.658 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 2.721461e-01 | 0.565 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 2.706190e-01 | 0.568 |
R-HSA-195721 | Signaling by WNT | 4.634010e-02 | 1.334 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.003949e-01 | 0.998 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.571356e-01 | 0.804 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 1.707568e-01 | 0.768 |
R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 1.774852e-01 | 0.751 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.167329e-01 | 0.664 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.541215e-01 | 0.595 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.541215e-01 | 0.595 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 2.780577e-01 | 0.556 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.167329e-01 | 0.664 |
R-HSA-4086400 | PCP/CE pathway | 1.553922e-01 | 0.809 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 7.061912e-02 | 1.151 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 1.221037e-01 | 0.913 |
R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 1.432925e-01 | 0.844 |
R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 1.432925e-01 | 0.844 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.295337e-01 | 0.888 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.571356e-01 | 0.804 |
R-HSA-182971 | EGFR downregulation | 2.601784e-01 | 0.585 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.707568e-01 | 0.768 |
R-HSA-4086398 | Ca2+ pathway | 1.413725e-01 | 0.850 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 9.304093e-02 | 1.031 |
R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.149258e-01 | 0.940 |
R-HSA-9839394 | TGFBR3 expression | 2.678520e-02 | 1.572 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.221037e-01 | 0.913 |
R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.292238e-01 | 0.889 |
R-HSA-9027284 | Erythropoietin activates RAS | 1.432925e-01 | 0.844 |
R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 1.502420e-01 | 0.823 |
R-HSA-163615 | PKA activation | 1.707568e-01 | 0.768 |
R-HSA-909733 | Interferon alpha/beta signaling | 2.824901e-01 | 0.549 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.480154e-01 | 0.606 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.877837e-02 | 1.231 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.386029e-01 | 0.858 |
R-HSA-4839726 | Chromatin organization | 1.770120e-01 | 0.752 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.541215e-01 | 0.595 |
R-HSA-9768777 | Regulation of NPAS4 gene transcription | 9.304093e-02 | 1.031 |
R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 1.221037e-01 | 0.913 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.639737e-01 | 0.785 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.639737e-01 | 0.785 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.774852e-01 | 0.751 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 1.973471e-01 | 0.705 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 2.038613e-01 | 0.691 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 2.230910e-01 | 0.652 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 2.418597e-01 | 0.616 |
R-HSA-177929 | Signaling by EGFR | 9.623297e-02 | 1.017 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.983383e-02 | 1.156 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.621809e-02 | 1.581 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.042487e-02 | 1.297 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 2.839216e-01 | 0.547 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 5.536653e-02 | 1.257 |
R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 1.707568e-01 | 0.768 |
R-HSA-167044 | Signalling to RAS | 1.907799e-01 | 0.719 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 2.661864e-01 | 0.575 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.817808e-02 | 1.166 |
R-HSA-9930044 | Nuclear RNA decay | 2.721461e-01 | 0.565 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.734644e-01 | 0.761 |
R-HSA-1266695 | Interleukin-7 signaling | 2.678520e-02 | 1.572 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 2.293979e-01 | 0.639 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.639737e-01 | 0.785 |
R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 2.038613e-01 | 0.691 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 2.167329e-01 | 0.664 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.907799e-01 | 0.719 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.907799e-01 | 0.719 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 2.480154e-01 | 0.606 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 2.541215e-01 | 0.595 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 2.897383e-01 | 0.538 |
R-HSA-5689877 | Josephin domain DUBs | 1.003949e-01 | 0.998 |
R-HSA-9675151 | Disorders of Developmental Biology | 1.571356e-01 | 0.804 |
R-HSA-9671555 | Signaling by PDGFR in disease | 1.973471e-01 | 0.705 |
R-HSA-912526 | Interleukin receptor SHC signaling | 2.103231e-01 | 0.677 |
R-HSA-5689901 | Metalloprotease DUBs | 2.293979e-01 | 0.639 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.222567e-01 | 0.913 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.721461e-01 | 0.565 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 2.897383e-01 | 0.538 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.610734e-01 | 0.793 |
R-HSA-9823730 | Formation of definitive endoderm | 1.841594e-01 | 0.735 |
R-HSA-5693537 | Resolution of D-Loop Structures | 2.780577e-01 | 0.556 |
R-HSA-9659379 | Sensory processing of sound | 1.582279e-01 | 0.801 |
R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.292238e-01 | 0.889 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.432925e-01 | 0.844 |
R-HSA-210993 | Tie2 Signaling | 1.707568e-01 | 0.768 |
R-HSA-392517 | Rap1 signalling | 1.774852e-01 | 0.751 |
R-HSA-111931 | PKA-mediated phosphorylation of CREB | 1.907799e-01 | 0.719 |
R-HSA-193648 | NRAGE signals death through JNK | 9.623297e-02 | 1.017 |
R-HSA-525793 | Myogenesis | 2.293979e-01 | 0.639 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.276511e-01 | 0.894 |
R-HSA-6806834 | Signaling by MET | 1.610734e-01 | 0.793 |
R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 2.541215e-01 | 0.595 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 1.362866e-01 | 0.866 |
R-HSA-156711 | Polo-like kinase mediated events | 1.707568e-01 | 0.768 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.331009e-01 | 0.876 |
R-HSA-8953854 | Metabolism of RNA | 2.624319e-01 | 0.581 |
R-HSA-1433559 | Regulation of KIT signaling | 1.362866e-01 | 0.866 |
R-HSA-4791275 | Signaling by WNT in cancer | 3.880242e-02 | 1.411 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.042487e-02 | 1.297 |
R-HSA-9907900 | Proteasome assembly | 6.757124e-02 | 1.170 |
R-HSA-166208 | mTORC1-mediated signalling | 2.038613e-01 | 0.691 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 9.623297e-02 | 1.017 |
R-HSA-186763 | Downstream signal transduction | 2.601784e-01 | 0.585 |
R-HSA-5633007 | Regulation of TP53 Activity | 1.774696e-01 | 0.751 |
R-HSA-9707616 | Heme signaling | 1.116474e-01 | 0.952 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 1.907799e-01 | 0.719 |
R-HSA-69275 | G2/M Transition | 2.337114e-01 | 0.631 |
R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.907799e-01 | 0.719 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.293979e-01 | 0.639 |
R-HSA-453274 | Mitotic G2-G2/M phases | 2.380076e-01 | 0.623 |
R-HSA-9614085 | FOXO-mediated transcription | 2.255054e-01 | 0.647 |
R-HSA-3247509 | Chromatin modifying enzymes | 1.536464e-01 | 0.813 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.973471e-01 | 0.705 |
R-HSA-380108 | Chemokine receptors bind chemokines | 7.912519e-02 | 1.102 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 2.356540e-01 | 0.628 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 8.562729e-02 | 1.067 |
R-HSA-9842663 | Signaling by LTK | 1.221037e-01 | 0.913 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.642473e-02 | 1.333 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 2.404579e-01 | 0.619 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 2.356540e-01 | 0.628 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.432925e-01 | 0.844 |
R-HSA-1980145 | Signaling by NOTCH2 | 2.839216e-01 | 0.547 |
R-HSA-9839373 | Signaling by TGFBR3 | 7.212105e-02 | 1.142 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.734812e-01 | 0.563 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 2.167329e-01 | 0.664 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.601784e-01 | 0.585 |
R-HSA-8853659 | RET signaling | 2.955081e-01 | 0.529 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.734812e-01 | 0.563 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.026975e-01 | 0.988 |
R-HSA-9006335 | Signaling by Erythropoietin | 2.480154e-01 | 0.606 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 9.623297e-02 | 1.017 |
R-HSA-9669938 | Signaling by KIT in disease | 2.038613e-01 | 0.691 |
R-HSA-9682385 | FLT3 signaling in disease | 2.955081e-01 | 0.529 |
R-HSA-5693538 | Homology Directed Repair | 2.914903e-01 | 0.535 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.219809e-02 | 1.654 |
R-HSA-416482 | G alpha (12/13) signalling events | 1.553922e-01 | 0.809 |
R-HSA-376176 | Signaling by ROBO receptors | 2.706190e-01 | 0.568 |
R-HSA-5688426 | Deubiquitination | 1.866830e-01 | 0.729 |
R-HSA-8941326 | RUNX2 regulates bone development | 4.840957e-02 | 1.315 |
R-HSA-1169408 | ISG15 antiviral mechanism | 1.469472e-01 | 0.833 |
R-HSA-187687 | Signalling to ERKs | 2.897383e-01 | 0.538 |
R-HSA-8983432 | Interleukin-15 signaling | 1.221037e-01 | 0.913 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.413725e-01 | 0.850 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.020103e-01 | 0.695 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 2.839216e-01 | 0.547 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 9.522202e-02 | 1.021 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.165687e-01 | 0.664 |
R-HSA-111933 | Calmodulin induced events | 2.955081e-01 | 0.529 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.418597e-01 | 0.616 |
R-HSA-354192 | Integrin signaling | 2.721461e-01 | 0.565 |
R-HSA-111997 | CaM pathway | 2.955081e-01 | 0.529 |
R-HSA-9006936 | Signaling by TGFB family members | 1.774696e-01 | 0.751 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.195441e-01 | 0.658 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 2.661864e-01 | 0.575 |
R-HSA-2028269 | Signaling by Hippo | 1.639737e-01 | 0.785 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.721461e-01 | 0.565 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.661864e-01 | 0.575 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 2.255054e-01 | 0.647 |
R-HSA-4641258 | Degradation of DVL | 3.012314e-01 | 0.521 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.012314e-01 | 0.521 |
R-HSA-196757 | Metabolism of folate and pterines | 3.012314e-01 | 0.521 |
R-HSA-212165 | Epigenetic regulation of gene expression | 3.054025e-01 | 0.515 |
R-HSA-8875878 | MET promotes cell motility | 3.069085e-01 | 0.513 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.125399e-01 | 0.505 |
R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.125399e-01 | 0.505 |
R-HSA-201556 | Signaling by ALK | 3.125399e-01 | 0.505 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.181259e-01 | 0.497 |
R-HSA-3371568 | Attenuation phase | 3.181259e-01 | 0.497 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.181259e-01 | 0.497 |
R-HSA-451927 | Interleukin-2 family signaling | 3.181259e-01 | 0.497 |
R-HSA-3214841 | PKMTs methylate histone lysines | 3.236668e-01 | 0.490 |
R-HSA-9607240 | FLT3 Signaling | 3.236668e-01 | 0.490 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.243414e-01 | 0.489 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 3.291630e-01 | 0.483 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 3.291630e-01 | 0.483 |
R-HSA-991365 | Activation of GABAB receptors | 3.346149e-01 | 0.475 |
R-HSA-977444 | GABA B receptor activation | 3.346149e-01 | 0.475 |
R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.346149e-01 | 0.475 |
R-HSA-111996 | Ca-dependent events | 3.346149e-01 | 0.475 |
R-HSA-165159 | MTOR signalling | 3.346149e-01 | 0.475 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.346149e-01 | 0.475 |
R-HSA-9843745 | Adipogenesis | 3.362008e-01 | 0.473 |
R-HSA-9909396 | Circadian clock | 3.391565e-01 | 0.470 |
R-HSA-5654743 | Signaling by FGFR4 | 3.400228e-01 | 0.468 |
R-HSA-1433557 | Signaling by SCF-KIT | 3.400228e-01 | 0.468 |
R-HSA-2172127 | DAP12 interactions | 3.453871e-01 | 0.462 |
R-HSA-3214858 | RMTs methylate histone arginines | 3.453871e-01 | 0.462 |
R-HSA-3928662 | EPHB-mediated forward signaling | 3.453871e-01 | 0.462 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.453871e-01 | 0.462 |
R-HSA-162582 | Signal Transduction | 3.453893e-01 | 0.462 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 3.507082e-01 | 0.455 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.507082e-01 | 0.455 |
R-HSA-6783310 | Fanconi Anemia Pathway | 3.507082e-01 | 0.455 |
R-HSA-5654741 | Signaling by FGFR3 | 3.507082e-01 | 0.455 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.507082e-01 | 0.455 |
R-HSA-1489509 | DAG and IP3 signaling | 3.507082e-01 | 0.455 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.559863e-01 | 0.449 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 3.559863e-01 | 0.449 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.559863e-01 | 0.449 |
R-HSA-75153 | Apoptotic execution phase | 3.559863e-01 | 0.449 |
R-HSA-9948299 | Ribosome-associated quality control | 3.597294e-01 | 0.444 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.612218e-01 | 0.442 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.664151e-01 | 0.436 |
R-HSA-9634597 | GPER1 signaling | 3.664151e-01 | 0.436 |
R-HSA-9031628 | NGF-stimulated transcription | 3.664151e-01 | 0.436 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 3.715665e-01 | 0.430 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.715665e-01 | 0.430 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.715665e-01 | 0.430 |
R-HSA-157858 | Gap junction trafficking and regulation | 3.715665e-01 | 0.430 |
R-HSA-73893 | DNA Damage Bypass | 3.715665e-01 | 0.430 |
R-HSA-73894 | DNA Repair | 3.734600e-01 | 0.428 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 3.766763e-01 | 0.424 |
R-HSA-3371571 | HSF1-dependent transactivation | 3.817449e-01 | 0.418 |
R-HSA-1640170 | Cell Cycle | 3.822465e-01 | 0.418 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 3.867726e-01 | 0.413 |
R-HSA-72187 | mRNA 3'-end processing | 3.867726e-01 | 0.413 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.867726e-01 | 0.413 |
R-HSA-166520 | Signaling by NTRKs | 3.915708e-01 | 0.407 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.917597e-01 | 0.407 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.917597e-01 | 0.407 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.917597e-01 | 0.407 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.917597e-01 | 0.407 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.943478e-01 | 0.404 |
R-HSA-9758941 | Gastrulation | 3.944319e-01 | 0.404 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.967065e-01 | 0.402 |
R-HSA-9679191 | Potential therapeutics for SARS | 3.972869e-01 | 0.401 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.016135e-01 | 0.396 |
R-HSA-418597 | G alpha (z) signalling events | 4.016135e-01 | 0.396 |
R-HSA-9012852 | Signaling by NOTCH3 | 4.016135e-01 | 0.396 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.029786e-01 | 0.395 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 4.058151e-01 | 0.392 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.064808e-01 | 0.391 |
R-HSA-5654736 | Signaling by FGFR1 | 4.064808e-01 | 0.391 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.086451e-01 | 0.389 |
R-HSA-73887 | Death Receptor Signaling | 4.086451e-01 | 0.389 |
R-HSA-112399 | IRS-mediated signalling | 4.113088e-01 | 0.386 |
R-HSA-1989781 | PPARA activates gene expression | 4.114688e-01 | 0.386 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.160979e-01 | 0.381 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.170963e-01 | 0.380 |
R-HSA-913531 | Interferon Signaling | 4.174975e-01 | 0.379 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.208483e-01 | 0.376 |
R-HSA-186712 | Regulation of beta-cell development | 4.208483e-01 | 0.376 |
R-HSA-877300 | Interferon gamma signaling | 4.226971e-01 | 0.374 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.255603e-01 | 0.371 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.255603e-01 | 0.371 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.255603e-01 | 0.371 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.255603e-01 | 0.371 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.255603e-01 | 0.371 |
R-HSA-977443 | GABA receptor activation | 4.255603e-01 | 0.371 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.255603e-01 | 0.371 |
R-HSA-983189 | Kinesins | 4.255603e-01 | 0.371 |
R-HSA-1227986 | Signaling by ERBB2 | 4.255603e-01 | 0.371 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.255603e-01 | 0.371 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.255603e-01 | 0.371 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.302343e-01 | 0.366 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.302343e-01 | 0.366 |
R-HSA-445717 | Aquaporin-mediated transport | 4.302343e-01 | 0.366 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.302343e-01 | 0.366 |
R-HSA-9793380 | Formation of paraxial mesoderm | 4.302343e-01 | 0.366 |
R-HSA-112043 | PLC beta mediated events | 4.302343e-01 | 0.366 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.348705e-01 | 0.362 |
R-HSA-6784531 | tRNA processing in the nucleus | 4.348705e-01 | 0.362 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 4.348705e-01 | 0.362 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.348705e-01 | 0.362 |
R-HSA-186797 | Signaling by PDGF | 4.348705e-01 | 0.362 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.394693e-01 | 0.357 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.394693e-01 | 0.357 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.394693e-01 | 0.357 |
R-HSA-8848021 | Signaling by PTK6 | 4.394693e-01 | 0.357 |
R-HSA-74751 | Insulin receptor signalling cascade | 4.440310e-01 | 0.353 |
R-HSA-2428924 | IGF1R signaling cascade | 4.440310e-01 | 0.353 |
R-HSA-9824443 | Parasitic Infection Pathways | 4.440498e-01 | 0.353 |
R-HSA-9658195 | Leishmania infection | 4.440498e-01 | 0.353 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.485558e-01 | 0.348 |
R-HSA-1234174 | Cellular response to hypoxia | 4.485558e-01 | 0.348 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.557075e-01 | 0.341 |
R-HSA-112040 | G-protein mediated events | 4.574961e-01 | 0.340 |
R-HSA-5693606 | DNA Double Strand Break Response | 4.574961e-01 | 0.340 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.574961e-01 | 0.340 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.611054e-01 | 0.336 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.619122e-01 | 0.335 |
R-HSA-199991 | Membrane Trafficking | 4.627933e-01 | 0.335 |
R-HSA-5689880 | Ub-specific processing proteases | 4.637928e-01 | 0.334 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 4.706376e-01 | 0.327 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.706376e-01 | 0.327 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.706376e-01 | 0.327 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 4.749474e-01 | 0.323 |
R-HSA-453276 | Regulation of mitotic cell cycle | 4.749474e-01 | 0.323 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.749474e-01 | 0.323 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.749474e-01 | 0.323 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.792225e-01 | 0.319 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.792225e-01 | 0.319 |
R-HSA-69052 | Switching of origins to a post-replicative state | 4.834630e-01 | 0.316 |
R-HSA-69473 | G2/M DNA damage checkpoint | 4.876693e-01 | 0.312 |
R-HSA-1226099 | Signaling by FGFR in disease | 4.876693e-01 | 0.312 |
R-HSA-9013694 | Signaling by NOTCH4 | 4.876693e-01 | 0.312 |
R-HSA-1236394 | Signaling by ERBB4 | 4.876693e-01 | 0.312 |
R-HSA-1980143 | Signaling by NOTCH1 | 4.959801e-01 | 0.305 |
R-HSA-375276 | Peptide ligand-binding receptors | 4.980034e-01 | 0.303 |
R-HSA-72766 | Translation | 4.996056e-01 | 0.301 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.000852e-01 | 0.301 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.031436e-01 | 0.298 |
R-HSA-1280218 | Adaptive Immune System | 5.046945e-01 | 0.297 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.081961e-01 | 0.294 |
R-HSA-5654738 | Signaling by FGFR2 | 5.122024e-01 | 0.291 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 5.161764e-01 | 0.287 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 5.161764e-01 | 0.287 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.201182e-01 | 0.284 |
R-HSA-69278 | Cell Cycle, Mitotic | 5.218734e-01 | 0.282 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 5.240281e-01 | 0.281 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.279065e-01 | 0.277 |
R-HSA-389948 | Co-inhibition by PD-1 | 5.332695e-01 | 0.273 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.355693e-01 | 0.271 |
R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.393543e-01 | 0.268 |
R-HSA-156902 | Peptide chain elongation | 5.468327e-01 | 0.262 |
R-HSA-1236974 | ER-Phagosome pathway | 5.505266e-01 | 0.259 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.541906e-01 | 0.256 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.578250e-01 | 0.254 |
R-HSA-156842 | Eukaryotic Translation Elongation | 5.650057e-01 | 0.248 |
R-HSA-74752 | Signaling by Insulin receptor | 5.650057e-01 | 0.248 |
R-HSA-2682334 | EPH-Ephrin signaling | 5.650057e-01 | 0.248 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 5.685526e-01 | 0.245 |
R-HSA-68867 | Assembly of the pre-replicative complex | 5.685526e-01 | 0.245 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.755605e-01 | 0.240 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.755605e-01 | 0.240 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 5.790219e-01 | 0.237 |
R-HSA-72764 | Eukaryotic Translation Termination | 5.790219e-01 | 0.237 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 5.824553e-01 | 0.235 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 5.824553e-01 | 0.235 |
R-HSA-190236 | Signaling by FGFR | 5.892391e-01 | 0.230 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.906779e-01 | 0.229 |
R-HSA-3214847 | HATs acetylate histones | 5.925898e-01 | 0.227 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 5.959134e-01 | 0.225 |
R-HSA-5610787 | Hedgehog 'off' state | 5.959134e-01 | 0.225 |
R-HSA-2408557 | Selenocysteine synthesis | 5.992101e-01 | 0.222 |
R-HSA-9842860 | Regulation of endogenous retroelements | 6.024801e-01 | 0.220 |
R-HSA-192823 | Viral mRNA Translation | 6.057236e-01 | 0.218 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.089409e-01 | 0.215 |
R-HSA-111885 | Opioid Signalling | 6.089409e-01 | 0.215 |
R-HSA-72312 | rRNA processing | 6.095577e-01 | 0.215 |
R-HSA-9833110 | RSV-host interactions | 6.121321e-01 | 0.213 |
R-HSA-5696398 | Nucleotide Excision Repair | 6.152975e-01 | 0.211 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 6.184372e-01 | 0.209 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.215515e-01 | 0.207 |
R-HSA-69239 | Synthesis of DNA | 6.215515e-01 | 0.207 |
R-HSA-1236975 | Antigen processing-Cross presentation | 6.246405e-01 | 0.204 |
R-HSA-69002 | DNA Replication Pre-Initiation | 6.277046e-01 | 0.202 |
R-HSA-2871796 | FCERI mediated MAPK activation | 6.367486e-01 | 0.196 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.376803e-01 | 0.195 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.397145e-01 | 0.194 |
R-HSA-1266738 | Developmental Biology | 6.457327e-01 | 0.190 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.513399e-01 | 0.186 |
R-HSA-9007101 | Rab regulation of trafficking | 6.570122e-01 | 0.182 |
R-HSA-1592230 | Mitochondrial biogenesis | 6.570122e-01 | 0.182 |
R-HSA-2980736 | Peptide hormone metabolism | 6.570122e-01 | 0.182 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.588937e-01 | 0.181 |
R-HSA-68875 | Mitotic Prophase | 6.653494e-01 | 0.177 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.680836e-01 | 0.175 |
R-HSA-3371556 | Cellular response to heat stress | 6.680836e-01 | 0.175 |
R-HSA-5653656 | Vesicle-mediated transport | 6.717392e-01 | 0.173 |
R-HSA-2132295 | MHC class II antigen presentation | 6.734855e-01 | 0.172 |
R-HSA-422475 | Axon guidance | 6.797000e-01 | 0.168 |
R-HSA-194138 | Signaling by VEGF | 6.814252e-01 | 0.167 |
R-HSA-9711123 | Cellular response to chemical stress | 6.816474e-01 | 0.166 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.840290e-01 | 0.165 |
R-HSA-69481 | G2/M Checkpoints | 6.866116e-01 | 0.163 |
R-HSA-9679506 | SARS-CoV Infections | 6.929391e-01 | 0.159 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.016734e-01 | 0.154 |
R-HSA-9018519 | Estrogen-dependent gene expression | 7.136744e-01 | 0.146 |
R-HSA-163685 | Integration of energy metabolism | 7.136744e-01 | 0.146 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.160165e-01 | 0.145 |
R-HSA-5358351 | Signaling by Hedgehog | 7.183396e-01 | 0.144 |
R-HSA-9664407 | Parasite infection | 7.229293e-01 | 0.141 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 7.229293e-01 | 0.141 |
R-HSA-9664417 | Leishmania phagocytosis | 7.229293e-01 | 0.141 |
R-HSA-372790 | Signaling by GPCR | 7.244983e-01 | 0.140 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.251962e-01 | 0.140 |
R-HSA-9675108 | Nervous system development | 7.267485e-01 | 0.139 |
R-HSA-69242 | S Phase | 7.426814e-01 | 0.129 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.489498e-01 | 0.126 |
R-HSA-9609507 | Protein localization | 7.530443e-01 | 0.123 |
R-HSA-69306 | DNA Replication | 7.530443e-01 | 0.123 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.570725e-01 | 0.121 |
R-HSA-9711097 | Cellular response to starvation | 7.629928e-01 | 0.117 |
R-HSA-109581 | Apoptosis | 7.706644e-01 | 0.113 |
R-HSA-2467813 | Separation of Sister Chromatids | 7.744073e-01 | 0.111 |
R-HSA-2408522 | Selenoamino acid metabolism | 7.744073e-01 | 0.111 |
R-HSA-72306 | tRNA processing | 7.870364e-01 | 0.104 |
R-HSA-418555 | G alpha (s) signalling events | 7.887823e-01 | 0.103 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.922316e-01 | 0.101 |
R-HSA-9664433 | Leishmania parasite growth and survival | 7.922316e-01 | 0.101 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.922316e-01 | 0.101 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.922316e-01 | 0.101 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.939353e-01 | 0.100 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 7.942829e-01 | 0.100 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.956251e-01 | 0.099 |
R-HSA-9678108 | SARS-CoV-1 Infection | 7.956251e-01 | 0.099 |
R-HSA-168255 | Influenza Infection | 8.022478e-01 | 0.096 |
R-HSA-2559583 | Cellular Senescence | 8.038699e-01 | 0.095 |
R-HSA-597592 | Post-translational protein modification | 8.157771e-01 | 0.088 |
R-HSA-68877 | Mitotic Prometaphase | 8.237939e-01 | 0.084 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 8.280986e-01 | 0.082 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.336763e-01 | 0.079 |
R-HSA-428157 | Sphingolipid metabolism | 8.350424e-01 | 0.078 |
R-HSA-5357801 | Programmed Cell Death | 8.417078e-01 | 0.075 |
R-HSA-68886 | M Phase | 8.423075e-01 | 0.075 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.433110e-01 | 0.074 |
R-HSA-8953897 | Cellular responses to stimuli | 8.439057e-01 | 0.074 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.505925e-01 | 0.070 |
R-HSA-392499 | Metabolism of proteins | 8.521624e-01 | 0.069 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.539766e-01 | 0.069 |
R-HSA-68882 | Mitotic Anaphase | 8.554454e-01 | 0.068 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 8.566340e-01 | 0.067 |
R-HSA-418990 | Adherens junctions interactions | 8.578129e-01 | 0.067 |
R-HSA-8951664 | Neddylation | 8.612922e-01 | 0.065 |
R-HSA-418594 | G alpha (i) signalling events | 8.657324e-01 | 0.063 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 8.690853e-01 | 0.061 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.712310e-01 | 0.060 |
R-HSA-500792 | GPCR ligand binding | 8.770243e-01 | 0.057 |
R-HSA-8939211 | ESR-mediated signaling | 8.784697e-01 | 0.056 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 8.784697e-01 | 0.056 |
R-HSA-157118 | Signaling by NOTCH | 8.814470e-01 | 0.055 |
R-HSA-421270 | Cell-cell junction organization | 8.917576e-01 | 0.050 |
R-HSA-388396 | GPCR downstream signalling | 8.919478e-01 | 0.050 |
R-HSA-449147 | Signaling by Interleukins | 9.000073e-01 | 0.046 |
R-HSA-416476 | G alpha (q) signalling events | 9.028008e-01 | 0.044 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 9.105281e-01 | 0.041 |
R-HSA-446728 | Cell junction organization | 9.134455e-01 | 0.039 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.141600e-01 | 0.039 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.162684e-01 | 0.038 |
R-HSA-5673001 | RAF/MAP kinase cascade | 9.209904e-01 | 0.036 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 9.254481e-01 | 0.034 |
R-HSA-2262752 | Cellular responses to stress | 9.300616e-01 | 0.031 |
R-HSA-1500931 | Cell-Cell communication | 9.368551e-01 | 0.028 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 9.389195e-01 | 0.027 |
R-HSA-112315 | Transmission across Chemical Synapses | 9.404236e-01 | 0.027 |
R-HSA-8957322 | Metabolism of steroids | 9.409168e-01 | 0.026 |
R-HSA-9006925 | Intracellular signaling by second messengers | 9.491321e-01 | 0.023 |
R-HSA-5683057 | MAPK family signaling cascades | 9.512056e-01 | 0.022 |
R-HSA-9694516 | SARS-CoV-2 Infection | 9.520114e-01 | 0.021 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 9.572936e-01 | 0.019 |
R-HSA-168256 | Immune System | 9.573555e-01 | 0.019 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.576480e-01 | 0.019 |
R-HSA-9824446 | Viral Infection Pathways | 9.607254e-01 | 0.017 |
R-HSA-5663205 | Infectious disease | 9.735991e-01 | 0.012 |
R-HSA-112316 | Neuronal System | 9.823978e-01 | 0.008 |
R-HSA-168249 | Innate Immune System | 9.876192e-01 | 0.005 |
R-HSA-109582 | Hemostasis | 9.904586e-01 | 0.004 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.950298e-01 | 0.002 |
R-HSA-1643685 | Disease | 9.980573e-01 | 0.001 |
R-HSA-9709957 | Sensory Perception | 9.997149e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 9.997335e-01 | 0.000 |
R-HSA-382551 | Transport of small molecules | 9.997787e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.853 | 0.452 | 1 | 0.847 |
SRPK1 |
0.850 | 0.482 | -3 | 0.845 |
HIPK4 |
0.848 | 0.516 | 1 | 0.853 |
HIPK2 |
0.844 | 0.563 | 1 | 0.848 |
PIM3 |
0.841 | 0.340 | -3 | 0.866 |
KIS |
0.841 | 0.415 | 1 | 0.864 |
DYRK2 |
0.841 | 0.536 | 1 | 0.879 |
SRPK2 |
0.839 | 0.442 | -3 | 0.812 |
CDKL1 |
0.838 | 0.432 | -3 | 0.854 |
CDKL5 |
0.838 | 0.406 | -3 | 0.854 |
COT |
0.837 | 0.135 | 2 | 0.820 |
CDK18 |
0.836 | 0.468 | 1 | 0.838 |
CLK2 |
0.836 | 0.462 | -3 | 0.844 |
NLK |
0.835 | 0.427 | 1 | 0.874 |
ICK |
0.834 | 0.465 | -3 | 0.857 |
HIPK1 |
0.833 | 0.545 | 1 | 0.881 |
NDR2 |
0.832 | 0.214 | -3 | 0.841 |
PIM1 |
0.832 | 0.345 | -3 | 0.853 |
CDK7 |
0.831 | 0.433 | 1 | 0.868 |
CDK5 |
0.830 | 0.435 | 1 | 0.874 |
CDK1 |
0.829 | 0.431 | 1 | 0.853 |
MOS |
0.829 | 0.185 | 1 | 0.782 |
DYRK1A |
0.829 | 0.535 | 1 | 0.874 |
DYRK4 |
0.829 | 0.505 | 1 | 0.855 |
CDK19 |
0.828 | 0.412 | 1 | 0.828 |
CDC7 |
0.827 | 0.094 | 1 | 0.747 |
CLK1 |
0.827 | 0.439 | -3 | 0.807 |
CDK8 |
0.827 | 0.399 | 1 | 0.843 |
SRPK3 |
0.827 | 0.379 | -3 | 0.824 |
CLK4 |
0.827 | 0.415 | -3 | 0.832 |
RSK2 |
0.827 | 0.304 | -3 | 0.848 |
JNK2 |
0.827 | 0.467 | 1 | 0.844 |
MTOR |
0.827 | 0.132 | 1 | 0.734 |
CDK17 |
0.826 | 0.443 | 1 | 0.809 |
PRKD1 |
0.826 | 0.276 | -3 | 0.812 |
P38G |
0.825 | 0.451 | 1 | 0.809 |
SKMLCK |
0.825 | 0.239 | -2 | 0.839 |
P90RSK |
0.824 | 0.307 | -3 | 0.851 |
PKN3 |
0.824 | 0.236 | -3 | 0.832 |
PRKD2 |
0.824 | 0.297 | -3 | 0.818 |
RSK3 |
0.824 | 0.292 | -3 | 0.835 |
ERK5 |
0.824 | 0.221 | 1 | 0.808 |
MAK |
0.823 | 0.531 | -2 | 0.726 |
NUAK2 |
0.823 | 0.258 | -3 | 0.843 |
CAMK1B |
0.823 | 0.246 | -3 | 0.831 |
CDK3 |
0.823 | 0.409 | 1 | 0.825 |
JNK3 |
0.822 | 0.441 | 1 | 0.857 |
P38B |
0.822 | 0.440 | 1 | 0.838 |
DYRK1B |
0.822 | 0.492 | 1 | 0.861 |
NDR1 |
0.821 | 0.186 | -3 | 0.837 |
HIPK3 |
0.821 | 0.512 | 1 | 0.867 |
CDK14 |
0.821 | 0.464 | 1 | 0.858 |
DYRK3 |
0.821 | 0.479 | 1 | 0.871 |
CDK13 |
0.820 | 0.394 | 1 | 0.857 |
ERK1 |
0.820 | 0.420 | 1 | 0.837 |
PKCD |
0.819 | 0.210 | 2 | 0.754 |
P38A |
0.819 | 0.421 | 1 | 0.864 |
MAPKAPK2 |
0.819 | 0.276 | -3 | 0.819 |
PRPK |
0.818 | -0.039 | -1 | 0.800 |
CDK16 |
0.818 | 0.428 | 1 | 0.821 |
CDK10 |
0.818 | 0.448 | 1 | 0.854 |
CDK12 |
0.817 | 0.409 | 1 | 0.842 |
ATR |
0.817 | 0.065 | 1 | 0.717 |
RSK4 |
0.817 | 0.290 | -3 | 0.853 |
PKN2 |
0.817 | 0.180 | -3 | 0.801 |
PKACB |
0.816 | 0.248 | -2 | 0.656 |
MARK4 |
0.816 | 0.149 | 4 | 0.811 |
CAMLCK |
0.816 | 0.198 | -2 | 0.808 |
AMPKA1 |
0.816 | 0.206 | -3 | 0.823 |
RAF1 |
0.815 | -0.015 | 1 | 0.700 |
DSTYK |
0.815 | -0.027 | 2 | 0.841 |
DAPK2 |
0.815 | 0.230 | -3 | 0.822 |
CDK9 |
0.815 | 0.397 | 1 | 0.859 |
P70S6KB |
0.815 | 0.238 | -3 | 0.832 |
AMPKA2 |
0.814 | 0.238 | -3 | 0.824 |
AKT2 |
0.814 | 0.330 | -3 | 0.804 |
AURC |
0.814 | 0.140 | -2 | 0.624 |
MAPKAPK3 |
0.814 | 0.234 | -3 | 0.805 |
LATS2 |
0.814 | 0.124 | -5 | 0.721 |
PRKX |
0.814 | 0.270 | -3 | 0.800 |
NIK |
0.814 | 0.179 | -3 | 0.801 |
PKACG |
0.813 | 0.173 | -2 | 0.736 |
IKKB |
0.812 | -0.069 | -2 | 0.708 |
P38D |
0.812 | 0.425 | 1 | 0.816 |
GCN2 |
0.812 | -0.127 | 2 | 0.749 |
PKCB |
0.812 | 0.199 | 2 | 0.714 |
QSK |
0.812 | 0.228 | 4 | 0.805 |
WNK1 |
0.812 | 0.083 | -2 | 0.846 |
TBK1 |
0.811 | -0.075 | 1 | 0.592 |
CDK2 |
0.811 | 0.308 | 1 | 0.870 |
BMPR2 |
0.811 | -0.101 | -2 | 0.845 |
PRKD3 |
0.811 | 0.287 | -3 | 0.791 |
MSK2 |
0.811 | 0.237 | -3 | 0.824 |
NUAK1 |
0.811 | 0.227 | -3 | 0.820 |
TGFBR2 |
0.810 | 0.018 | -2 | 0.782 |
GRK1 |
0.810 | 0.067 | -2 | 0.795 |
MST4 |
0.810 | 0.050 | 2 | 0.796 |
LATS1 |
0.810 | 0.192 | -3 | 0.847 |
PDHK4 |
0.810 | -0.178 | 1 | 0.734 |
CAMK2D |
0.810 | 0.128 | -3 | 0.798 |
RIPK3 |
0.809 | -0.006 | 3 | 0.792 |
MSK1 |
0.809 | 0.239 | -3 | 0.823 |
ERK2 |
0.809 | 0.381 | 1 | 0.852 |
CAMK2A |
0.809 | 0.187 | 2 | 0.755 |
PIM2 |
0.809 | 0.308 | -3 | 0.822 |
PKCA |
0.809 | 0.169 | 2 | 0.703 |
NEK6 |
0.809 | -0.022 | -2 | 0.836 |
TSSK1 |
0.809 | 0.171 | -3 | 0.832 |
SIK |
0.808 | 0.251 | -3 | 0.791 |
PKCG |
0.808 | 0.149 | 2 | 0.715 |
BMPR1B |
0.808 | 0.105 | 1 | 0.699 |
SGK3 |
0.807 | 0.269 | -3 | 0.810 |
IKKE |
0.807 | -0.101 | 1 | 0.591 |
MOK |
0.807 | 0.486 | 1 | 0.858 |
CHAK2 |
0.807 | 0.001 | -1 | 0.764 |
CAMK2G |
0.807 | -0.081 | 2 | 0.754 |
CAMK2B |
0.806 | 0.132 | 2 | 0.727 |
ULK2 |
0.806 | -0.131 | 2 | 0.721 |
MLK1 |
0.806 | -0.060 | 2 | 0.776 |
MLK2 |
0.806 | 0.037 | 2 | 0.775 |
GRK7 |
0.805 | 0.096 | 1 | 0.683 |
MYLK4 |
0.804 | 0.185 | -2 | 0.740 |
PAK1 |
0.804 | 0.109 | -2 | 0.745 |
NEK7 |
0.804 | -0.122 | -3 | 0.688 |
PHKG1 |
0.804 | 0.151 | -3 | 0.815 |
MELK |
0.803 | 0.195 | -3 | 0.803 |
NIM1 |
0.803 | 0.090 | 3 | 0.805 |
MNK2 |
0.803 | 0.097 | -2 | 0.747 |
MLK3 |
0.803 | 0.041 | 2 | 0.723 |
TSSK2 |
0.803 | 0.100 | -5 | 0.798 |
GRK5 |
0.803 | -0.119 | -3 | 0.730 |
IKKA |
0.803 | -0.042 | -2 | 0.708 |
PKG2 |
0.802 | 0.167 | -2 | 0.656 |
PKCZ |
0.802 | 0.127 | 2 | 0.739 |
FAM20C |
0.802 | 0.045 | 2 | 0.592 |
MARK3 |
0.801 | 0.160 | 4 | 0.771 |
PDHK1 |
0.801 | -0.197 | 1 | 0.704 |
JNK1 |
0.801 | 0.376 | 1 | 0.843 |
PAK3 |
0.801 | 0.081 | -2 | 0.739 |
HUNK |
0.801 | -0.072 | 2 | 0.749 |
MASTL |
0.800 | -0.095 | -2 | 0.789 |
PRP4 |
0.800 | 0.247 | -3 | 0.663 |
CAMK4 |
0.800 | 0.086 | -3 | 0.801 |
ATM |
0.800 | -0.005 | 1 | 0.663 |
BRSK1 |
0.799 | 0.173 | -3 | 0.810 |
QIK |
0.799 | 0.099 | -3 | 0.781 |
AURB |
0.799 | 0.091 | -2 | 0.621 |
IRE1 |
0.799 | 0.005 | 1 | 0.662 |
TGFBR1 |
0.799 | 0.034 | -2 | 0.801 |
PKACA |
0.799 | 0.229 | -2 | 0.603 |
AKT3 |
0.798 | 0.326 | -3 | 0.779 |
DLK |
0.798 | -0.074 | 1 | 0.686 |
PKCH |
0.798 | 0.125 | 2 | 0.690 |
ALK4 |
0.798 | 0.020 | -2 | 0.815 |
ANKRD3 |
0.798 | -0.049 | 1 | 0.714 |
BCKDK |
0.797 | -0.122 | -1 | 0.781 |
MARK2 |
0.797 | 0.137 | 4 | 0.738 |
RIPK1 |
0.797 | -0.055 | 1 | 0.678 |
AKT1 |
0.797 | 0.263 | -3 | 0.805 |
CAMK1G |
0.797 | 0.208 | -3 | 0.811 |
DCAMKL1 |
0.797 | 0.214 | -3 | 0.810 |
CDK6 |
0.797 | 0.380 | 1 | 0.848 |
NEK9 |
0.797 | -0.108 | 2 | 0.775 |
MNK1 |
0.797 | 0.089 | -2 | 0.753 |
CDK4 |
0.796 | 0.406 | 1 | 0.838 |
WNK3 |
0.796 | -0.140 | 1 | 0.673 |
ERK7 |
0.796 | 0.195 | 2 | 0.576 |
CHK1 |
0.796 | 0.129 | -3 | 0.805 |
MLK4 |
0.795 | -0.010 | 2 | 0.703 |
GRK6 |
0.795 | -0.094 | 1 | 0.714 |
IRE2 |
0.795 | 0.008 | 2 | 0.705 |
PKR |
0.795 | 0.013 | 1 | 0.712 |
SGK1 |
0.794 | 0.330 | -3 | 0.773 |
BRSK2 |
0.794 | 0.102 | -3 | 0.791 |
PAK6 |
0.794 | 0.086 | -2 | 0.634 |
ULK1 |
0.794 | -0.178 | -3 | 0.658 |
MEK1 |
0.793 | -0.060 | 2 | 0.789 |
PASK |
0.792 | 0.188 | -3 | 0.855 |
ACVR2B |
0.792 | -0.004 | -2 | 0.780 |
PKCT |
0.791 | 0.152 | 2 | 0.691 |
GRK4 |
0.791 | -0.137 | -2 | 0.823 |
TTBK2 |
0.791 | -0.139 | 2 | 0.648 |
SMG1 |
0.791 | -0.024 | 1 | 0.671 |
MARK1 |
0.791 | 0.110 | 4 | 0.774 |
MAPKAPK5 |
0.791 | 0.175 | -3 | 0.782 |
AURA |
0.791 | 0.056 | -2 | 0.589 |
YSK4 |
0.791 | -0.075 | 1 | 0.629 |
MPSK1 |
0.791 | 0.148 | 1 | 0.699 |
DNAPK |
0.790 | 0.016 | 1 | 0.613 |
ALK2 |
0.790 | 0.007 | -2 | 0.811 |
VRK2 |
0.790 | -0.024 | 1 | 0.764 |
GSK3A |
0.790 | 0.122 | 4 | 0.396 |
PAK2 |
0.790 | 0.041 | -2 | 0.723 |
SBK |
0.789 | 0.373 | -3 | 0.739 |
SMMLCK |
0.789 | 0.182 | -3 | 0.822 |
CAMK1D |
0.789 | 0.246 | -3 | 0.777 |
TLK2 |
0.789 | -0.035 | 1 | 0.649 |
ACVR2A |
0.788 | -0.027 | -2 | 0.758 |
DAPK3 |
0.788 | 0.212 | -3 | 0.834 |
PLK1 |
0.788 | -0.098 | -2 | 0.772 |
P70S6K |
0.787 | 0.220 | -3 | 0.790 |
DRAK1 |
0.787 | -0.011 | 1 | 0.661 |
DCAMKL2 |
0.787 | 0.132 | -3 | 0.811 |
PKCE |
0.786 | 0.181 | 2 | 0.704 |
NEK2 |
0.786 | -0.063 | 2 | 0.764 |
MST3 |
0.786 | 0.057 | 2 | 0.800 |
BMPR1A |
0.785 | 0.033 | 1 | 0.679 |
CHAK1 |
0.785 | -0.100 | 2 | 0.724 |
TAO3 |
0.784 | 0.034 | 1 | 0.670 |
PKN1 |
0.784 | 0.231 | -3 | 0.788 |
CHK2 |
0.783 | 0.287 | -3 | 0.757 |
PINK1 |
0.783 | -0.001 | 1 | 0.790 |
SSTK |
0.783 | 0.090 | 4 | 0.782 |
GRK2 |
0.782 | -0.054 | -2 | 0.720 |
PLK4 |
0.782 | -0.063 | 2 | 0.554 |
SNRK |
0.782 | -0.018 | 2 | 0.604 |
CAMK1A |
0.782 | 0.268 | -3 | 0.760 |
CK1E |
0.782 | -0.012 | -3 | 0.486 |
MEKK2 |
0.782 | -0.032 | 2 | 0.750 |
NEK5 |
0.781 | -0.024 | 1 | 0.681 |
ROCK2 |
0.781 | 0.231 | -3 | 0.820 |
DAPK1 |
0.781 | 0.194 | -3 | 0.831 |
WNK4 |
0.781 | -0.002 | -2 | 0.836 |
PKCI |
0.781 | 0.100 | 2 | 0.716 |
GSK3B |
0.780 | 0.024 | 4 | 0.392 |
MEK5 |
0.779 | -0.118 | 2 | 0.764 |
IRAK4 |
0.779 | -0.037 | 1 | 0.655 |
BRAF |
0.779 | -0.053 | -4 | 0.802 |
PERK |
0.779 | -0.108 | -2 | 0.802 |
MRCKB |
0.778 | 0.218 | -3 | 0.797 |
MEKK1 |
0.778 | -0.123 | 1 | 0.659 |
ZAK |
0.777 | -0.119 | 1 | 0.623 |
PDK1 |
0.777 | 0.104 | 1 | 0.677 |
GAK |
0.777 | 0.054 | 1 | 0.754 |
PLK3 |
0.777 | -0.137 | 2 | 0.703 |
TLK1 |
0.777 | -0.087 | -2 | 0.832 |
PHKG2 |
0.776 | 0.058 | -3 | 0.781 |
CK1D |
0.776 | -0.003 | -3 | 0.438 |
GCK |
0.776 | 0.058 | 1 | 0.667 |
MRCKA |
0.776 | 0.188 | -3 | 0.807 |
DMPK1 |
0.776 | 0.245 | -3 | 0.814 |
MEKK3 |
0.775 | -0.150 | 1 | 0.663 |
HRI |
0.775 | -0.164 | -2 | 0.813 |
PAK5 |
0.775 | 0.060 | -2 | 0.588 |
PAK4 |
0.775 | 0.073 | -2 | 0.593 |
LKB1 |
0.773 | 0.018 | -3 | 0.692 |
NEK8 |
0.772 | -0.059 | 2 | 0.763 |
NEK11 |
0.771 | -0.090 | 1 | 0.654 |
BUB1 |
0.771 | 0.137 | -5 | 0.760 |
TNIK |
0.771 | 0.049 | 3 | 0.870 |
HPK1 |
0.770 | 0.044 | 1 | 0.658 |
MST2 |
0.769 | -0.060 | 1 | 0.662 |
TAO2 |
0.769 | -0.047 | 2 | 0.794 |
CK1A2 |
0.769 | -0.033 | -3 | 0.446 |
CRIK |
0.769 | 0.271 | -3 | 0.821 |
GRK3 |
0.769 | -0.063 | -2 | 0.693 |
HGK |
0.767 | -0.006 | 3 | 0.874 |
KHS2 |
0.767 | 0.085 | 1 | 0.660 |
CK1G1 |
0.767 | -0.066 | -3 | 0.480 |
PBK |
0.767 | 0.093 | 1 | 0.687 |
LOK |
0.767 | 0.026 | -2 | 0.731 |
KHS1 |
0.766 | 0.062 | 1 | 0.641 |
ROCK1 |
0.766 | 0.206 | -3 | 0.800 |
MINK |
0.766 | -0.028 | 1 | 0.636 |
NEK4 |
0.766 | -0.066 | 1 | 0.642 |
PKG1 |
0.765 | 0.156 | -2 | 0.568 |
MEKK6 |
0.765 | -0.035 | 1 | 0.647 |
MAP3K15 |
0.765 | -0.047 | 1 | 0.621 |
CAMKK1 |
0.765 | -0.168 | -2 | 0.701 |
LRRK2 |
0.765 | -0.000 | 2 | 0.784 |
TAK1 |
0.764 | -0.047 | 1 | 0.668 |
CAMKK2 |
0.764 | -0.096 | -2 | 0.695 |
EEF2K |
0.763 | -0.046 | 3 | 0.827 |
SLK |
0.762 | -0.023 | -2 | 0.685 |
VRK1 |
0.761 | -0.077 | 2 | 0.772 |
CK2A2 |
0.760 | -0.041 | 1 | 0.645 |
NEK1 |
0.760 | -0.064 | 1 | 0.656 |
MST1 |
0.759 | -0.088 | 1 | 0.640 |
TTBK1 |
0.758 | -0.196 | 2 | 0.568 |
IRAK1 |
0.757 | -0.241 | -1 | 0.701 |
PLK2 |
0.756 | -0.087 | -3 | 0.662 |
HASPIN |
0.755 | 0.038 | -1 | 0.647 |
PDHK3_TYR |
0.755 | 0.229 | 4 | 0.804 |
TTK |
0.754 | -0.001 | -2 | 0.801 |
YSK1 |
0.754 | -0.050 | 2 | 0.754 |
OSR1 |
0.753 | -0.030 | 2 | 0.748 |
STK33 |
0.752 | -0.123 | 2 | 0.560 |
MEK2 |
0.750 | -0.194 | 2 | 0.744 |
CK2A1 |
0.750 | -0.052 | 1 | 0.629 |
MYO3B |
0.747 | 0.000 | 2 | 0.780 |
BIKE |
0.747 | 0.026 | 1 | 0.667 |
NEK3 |
0.746 | -0.106 | 1 | 0.615 |
PDHK4_TYR |
0.746 | 0.084 | 2 | 0.813 |
LIMK2_TYR |
0.745 | 0.184 | -3 | 0.773 |
MAP2K4_TYR |
0.745 | 0.100 | -1 | 0.813 |
TESK1_TYR |
0.744 | 0.080 | 3 | 0.896 |
MAP2K6_TYR |
0.744 | 0.070 | -1 | 0.808 |
RIPK2 |
0.744 | -0.232 | 1 | 0.584 |
MYO3A |
0.743 | -0.037 | 1 | 0.646 |
YANK3 |
0.743 | -0.049 | 2 | 0.368 |
PKMYT1_TYR |
0.742 | 0.071 | 3 | 0.870 |
BMPR2_TYR |
0.740 | 0.002 | -1 | 0.792 |
MAP2K7_TYR |
0.739 | -0.058 | 2 | 0.789 |
PDHK1_TYR |
0.738 | -0.030 | -1 | 0.795 |
TXK |
0.738 | 0.078 | 1 | 0.714 |
TAO1 |
0.738 | -0.075 | 1 | 0.586 |
CK1A |
0.737 | -0.051 | -3 | 0.364 |
EPHA6 |
0.737 | 0.023 | -1 | 0.786 |
ASK1 |
0.737 | -0.143 | 1 | 0.610 |
AAK1 |
0.735 | 0.063 | 1 | 0.597 |
ALPHAK3 |
0.734 | -0.093 | -1 | 0.696 |
PINK1_TYR |
0.734 | -0.091 | 1 | 0.727 |
RET |
0.733 | -0.050 | 1 | 0.674 |
EPHB4 |
0.733 | -0.015 | -1 | 0.774 |
TYRO3 |
0.732 | -0.049 | 3 | 0.827 |
LIMK1_TYR |
0.731 | -0.041 | 2 | 0.785 |
ROS1 |
0.731 | -0.033 | 3 | 0.806 |
TNK2 |
0.731 | 0.041 | 3 | 0.789 |
MST1R |
0.730 | -0.064 | 3 | 0.833 |
ABL2 |
0.730 | -0.026 | -1 | 0.749 |
CSF1R |
0.728 | -0.061 | 3 | 0.818 |
LCK |
0.728 | 0.005 | -1 | 0.748 |
YES1 |
0.727 | -0.050 | -1 | 0.767 |
DDR1 |
0.727 | -0.076 | 4 | 0.727 |
BLK |
0.726 | 0.023 | -1 | 0.748 |
FGR |
0.725 | -0.081 | 1 | 0.710 |
ABL1 |
0.725 | -0.052 | -1 | 0.746 |
INSRR |
0.724 | -0.075 | 3 | 0.781 |
TYK2 |
0.724 | -0.184 | 1 | 0.661 |
STLK3 |
0.724 | -0.192 | 1 | 0.595 |
JAK2 |
0.723 | -0.128 | 1 | 0.662 |
FER |
0.723 | -0.128 | 1 | 0.734 |
JAK3 |
0.722 | -0.107 | 1 | 0.650 |
ITK |
0.722 | -0.064 | -1 | 0.739 |
TNNI3K_TYR |
0.721 | 0.029 | 1 | 0.652 |
FGFR2 |
0.721 | -0.070 | 3 | 0.827 |
EPHB3 |
0.721 | -0.066 | -1 | 0.766 |
TNK1 |
0.721 | -0.007 | 3 | 0.804 |
SRMS |
0.721 | -0.084 | 1 | 0.711 |
KDR |
0.721 | -0.044 | 3 | 0.783 |
EPHA4 |
0.720 | -0.068 | 2 | 0.713 |
HCK |
0.720 | -0.098 | -1 | 0.753 |
AXL |
0.720 | -0.063 | 3 | 0.815 |
NEK10_TYR |
0.720 | -0.045 | 1 | 0.580 |
EPHB1 |
0.719 | -0.099 | 1 | 0.694 |
TEK |
0.719 | -0.056 | 3 | 0.771 |
MERTK |
0.718 | -0.070 | 3 | 0.802 |
EPHB2 |
0.718 | -0.083 | -1 | 0.748 |
BMX |
0.718 | -0.050 | -1 | 0.675 |
FGFR1 |
0.717 | -0.073 | 3 | 0.796 |
MET |
0.717 | -0.073 | 3 | 0.812 |
KIT |
0.717 | -0.124 | 3 | 0.819 |
DDR2 |
0.717 | 0.034 | 3 | 0.772 |
TEC |
0.717 | -0.065 | -1 | 0.704 |
PDGFRB |
0.716 | -0.149 | 3 | 0.828 |
FYN |
0.716 | -0.025 | -1 | 0.723 |
JAK1 |
0.715 | -0.058 | 1 | 0.601 |
FLT3 |
0.715 | -0.153 | 3 | 0.812 |
EPHA7 |
0.712 | -0.074 | 2 | 0.710 |
ALK |
0.711 | -0.110 | 3 | 0.742 |
WEE1_TYR |
0.711 | -0.085 | -1 | 0.704 |
FGFR3 |
0.710 | -0.095 | 3 | 0.799 |
CK1G3 |
0.709 | -0.085 | -3 | 0.328 |
EPHA1 |
0.709 | -0.094 | 3 | 0.789 |
LTK |
0.709 | -0.122 | 3 | 0.762 |
PTK2B |
0.708 | -0.051 | -1 | 0.736 |
BTK |
0.708 | -0.205 | -1 | 0.724 |
FRK |
0.708 | -0.111 | -1 | 0.762 |
YANK2 |
0.708 | -0.095 | 2 | 0.392 |
FLT1 |
0.707 | -0.138 | -1 | 0.733 |
PDGFRA |
0.707 | -0.197 | 3 | 0.825 |
INSR |
0.705 | -0.147 | 3 | 0.761 |
PTK6 |
0.705 | -0.184 | -1 | 0.685 |
EPHA3 |
0.705 | -0.144 | 2 | 0.679 |
LYN |
0.705 | -0.110 | 3 | 0.740 |
NTRK1 |
0.704 | -0.213 | -1 | 0.762 |
NTRK3 |
0.704 | -0.129 | -1 | 0.723 |
ERBB2 |
0.704 | -0.174 | 1 | 0.633 |
MATK |
0.704 | -0.113 | -1 | 0.666 |
EPHA5 |
0.704 | -0.098 | 2 | 0.692 |
PTK2 |
0.703 | -0.032 | -1 | 0.699 |
EPHA8 |
0.703 | -0.095 | -1 | 0.731 |
SRC |
0.702 | -0.092 | -1 | 0.725 |
NTRK2 |
0.701 | -0.212 | 3 | 0.783 |
FLT4 |
0.701 | -0.181 | 3 | 0.779 |
EGFR |
0.697 | -0.124 | 1 | 0.552 |
SYK |
0.697 | -0.061 | -1 | 0.680 |
CK1G2 |
0.694 | -0.077 | -3 | 0.408 |
CSK |
0.694 | -0.169 | 2 | 0.713 |
FGFR4 |
0.694 | -0.130 | -1 | 0.689 |
EPHA2 |
0.692 | -0.114 | -1 | 0.697 |
ERBB4 |
0.690 | -0.081 | 1 | 0.576 |
MUSK |
0.687 | -0.159 | 1 | 0.549 |
IGF1R |
0.687 | -0.171 | 3 | 0.702 |
ZAP70 |
0.685 | -0.039 | -1 | 0.629 |
FES |
0.675 | -0.165 | -1 | 0.656 |