Motif 194 (n=262)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A2RUS2 | DENND3 | S490 | ochoa|psp | DENN domain-containing protein 3 | Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}. |
A6NDE4 | RBMY1B | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member B | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
A6NEQ0 | RBMY1E | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
A6NHQ4 | EPOP | S36 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
A7KAX9 | ARHGAP32 | S1630 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
K7ELQ4 | ATF7-NPFF | S188 | ochoa | ATF7-NPFF readthrough | None |
O00148 | DDX39A | Y38 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
O00192 | ARVCF | S332 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
O14654 | IRS4 | S1231 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
O14686 | KMT2D | S42 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S2239 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S3208 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14827 | RASGRF2 | S793 | ochoa | Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}. |
O14964 | HGS | S310 | ochoa | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
O14965 | AURKA | S66 | ochoa | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
O15054 | KDM6B | S802 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
O15240 | VGF | S65 | ochoa | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). {ECO:0000250|UniProtKB:P20156}.; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). {ECO:0000250|UniProtKB:P20156, ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). {ECO:0000250|UniProtKB:Q0VGU4}.; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M.luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}. |
O15392 | BIRC5 | S20 | psp | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:20627126, PubMed:21364656, PubMed:25778398, PubMed:28218735, PubMed:9859993). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}. |
O43237 | DYNC1LI2 | S203 | ochoa | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. {ECO:0000305|PubMed:36071160}. |
O43294 | TGFB1I1 | S82 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
O43426 | SYNJ1 | S1292 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
O43432 | EIF4G3 | S1156 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
O43639 | NCK2 | S275 | ochoa | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}. |
O60269 | GPRIN2 | S24 | ochoa | G protein-regulated inducer of neurite outgrowth 2 (GRIN2) | May be involved in neurite outgrowth. {ECO:0000269|PubMed:10480904}. |
O60346 | PHLPP1 | S336 | ochoa|psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
O60356 | NUPR1 | S22 | ochoa | Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) | Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}. |
O60732 | MAGEC1 | S58 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
O75061 | DNAJC6 | S625 | ochoa | Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) | May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking (PubMed:18489706). Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). {ECO:0000250|UniProtKB:Q27974, ECO:0000269|PubMed:18489706}. |
O75154 | RAB11FIP3 | S52 | ochoa | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
O75781 | PALM | S356 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
O75962 | TRIO | S2426 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
O75995 | SASH3 | S349 | ochoa | SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog) | May function as a signaling adapter protein in lymphocytes. {ECO:0000250|UniProtKB:Q8K352}. |
O94804 | STK10 | S488 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
O94826 | TOMM70 | S110 | ochoa | Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). {ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:32728199, ECO:0000269|PubMed:35025629}. |
O94880 | PHF14 | S572 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
O95049 | TJP3 | S845 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
O95382 | MAP3K6 | S964 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
P03372 | ESR1 | S341 | psp | Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (PubMed:17922032). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity). {ECO:0000250|UniProtKB:P06211, ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.; FUNCTION: [Isoform 3]: Involved in activation of NOS3 and endothelial nitric oxide production (PubMed:21937726). Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor (PubMed:10970861). Binds to ERE and inhibits isoform 1 (PubMed:10970861). {ECO:0000269|PubMed:10970861, ECO:0000269|PubMed:21937726}. |
P05412 | JUN | S249 | ochoa|psp | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}. |
P05549 | TFAP2A | S223 | ochoa | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
P08651 | NFIC | S487 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
P09874 | PARP1 | S385 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
P0C7P1 | RBMY1D | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
P0C7T5 | ATXN1L | S215 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
P0DJD3 | RBMY1A1 | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
P0DJD4 | RBMY1C | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
P11137 | MAP2 | S1799 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P13498 | CYBA | S168 | ochoa | Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) | Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103, PubMed:17140397, PubMed:38355798). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:19948736). Aassociates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (PubMed:15824103, PubMed:17140397). {ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17140397, ECO:0000269|PubMed:19948736, ECO:0000269|PubMed:38355798}. |
P16871 | IL7R | S366 | ochoa | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) | Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
P18146 | EGR1 | S104 | psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
P20823 | HNF1A | S313 | ochoa | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
P21554 | CNR1 | S429 | psp | Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) | G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, but not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells, cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes (By similarity). In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712). {ECO:0000250|UniProtKB:O02777, ECO:0000250|UniProtKB:P47746, ECO:0000269|PubMed:15620723, ECO:0000269|PubMed:1718258, ECO:0000269|PubMed:17895407, ECO:0000269|PubMed:21895628, ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727}.; FUNCTION: [Isoform 1]: Binds both 2-arachidonoylglycerol (2-AG) and anandamide. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 2]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 2 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}.; FUNCTION: [Isoform 3]: Only binds 2-arachidonoylglycerol (2-AG) with high affinity. Contrary to its effect on isoform 1, 2-AG behaves as an inverse agonist on isoform 3 in assays measuring GTP binding to membranes. {ECO:0000269|PubMed:15620723}. |
P30305 | CDC25B | S169 | psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P31260 | HOXA10 | S322 | ochoa | Homeobox protein Hox-A10 (Homeobox protein Hox-1.8) (Homeobox protein Hox-1H) (PL) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. |
P31930 | UQCRC1 | S212 | ochoa | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179). {ECO:0000250|UniProtKB:P07256, ECO:0000250|UniProtKB:P31800, ECO:0000269|PubMed:33141179, ECO:0000305|PubMed:29243944}. |
P35568 | IRS1 | S463 | ochoa | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
P40337 | VHL | S111 | psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
P43268 | ETV4 | S149 | ochoa | ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3) | Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}. |
P46821 | MAP1B | S2218 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P46937 | YAP1 | S298 | ochoa | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
P50570 | DNM2 | S848 | psp | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
P51532 | SMARCA4 | S613 | ochoa|psp | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 (SMARCA4) (EC 3.6.4.-) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (Transcription activator BRG1) | ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (PubMed:20418909). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). {ECO:0000250|UniProtKB:Q3TKT4, ECO:0000250|UniProtKB:Q8K1P7, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:30339381, ECO:0000269|PubMed:32459350, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
P53350 | PLK1 | S331 | ochoa | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069, PubMed:28512243, PubMed:8991084). Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17218258, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:22325354, PubMed:23455478, PubMed:23509069, PubMed:25986610, PubMed:26811421, PubMed:28512243, PubMed:37440612, PubMed:37674080, PubMed:8991084). Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL (PubMed:16980960, PubMed:19509060). NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins (PubMed:12852856). Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1 (PubMed:12939256, PubMed:16247472, PubMed:17351640, PubMed:19468300, PubMed:19468302). Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains (PubMed:12939256, PubMed:17351640). Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation (PubMed:19468300, PubMed:19468302). Promotes the central spindle recruitment of ECT2 (PubMed:16247472). Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1 (PubMed:11202906, PubMed:12447691, PubMed:12524548, PubMed:19160488). Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1 (PubMed:11202906). Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase (PubMed:12447691, PubMed:12524548). Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity (PubMed:19160488). Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2 (PubMed:15148369, PubMed:15469984, PubMed:17376779, PubMed:18331714). PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation (PubMed:17617734). Required for kinetochore localization of BUB1B (PubMed:17376779). Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2 (By similarity). Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function (PubMed:18331714). Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome (PubMed:15148369, PubMed:15469984). Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53 (PubMed:19473992). Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA (PubMed:18521620). Contributes to the regulation of AURKA function (PubMed:18615013, PubMed:18662541). Also required for recovery after DNA damage checkpoint and entry into mitosis (PubMed:18615013, PubMed:18662541). Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Regulates mitotic progression by phosphorylating RIOK2 (PubMed:21880710). Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis (PubMed:27979967). Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (PubMed:37440612, PubMed:37674080). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (PubMed:21857149). {ECO:0000250|UniProtKB:P70032, ECO:0000250|UniProtKB:Q5F2C3, ECO:0000269|PubMed:11202906, ECO:0000269|PubMed:12207013, ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548, ECO:0000269|PubMed:12738781, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:12939256, ECO:0000269|PubMed:14532005, ECO:0000269|PubMed:14734534, ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:15148369, ECO:0000269|PubMed:15469984, ECO:0000269|PubMed:15661742, ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16247472, ECO:0000269|PubMed:16980960, ECO:0000269|PubMed:17081991, ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17351640, ECO:0000269|PubMed:17376779, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:18418051, ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:18521620, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19597481, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:21857149, ECO:0000269|PubMed:21880710, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:27979967, ECO:0000269|PubMed:37440612, ECO:0000269|PubMed:37674080, ECO:0000269|PubMed:8991084}. |
P54296 | MYOM2 | S549 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
P55198 | MLLT6 | S438 | ochoa | Protein AF-17 (ALL1-fused gene from chromosome 17 protein) | None |
P55287 | CDH11 | S714 | ochoa | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). {ECO:0000269|PubMed:33811546}. |
P58004 | SESN2 | S249 | ochoa | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684, ECO:0000269|PubMed:35114100, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
P81408 | ENTREP3 | S493 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
P81408 | ENTREP3 | S574 | ochoa | Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1) | None |
P98095 | FBLN2 | S578 | ochoa | Fibulin-2 (FIBL-2) | Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). {ECO:0000269|PubMed:17255108}. |
Q02750 | MAP2K1 | S304 | ochoa | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
Q04206 | RELA | S529 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
Q04637 | EIF4G1 | S704 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Q05209 | PTPN12 | S372 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
Q06413 | MEF2C | S183 | ochoa | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
Q07157 | TJP1 | S131 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q07157 | TJP1 | S411 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q07157 | TJP1 | S1446 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
Q12888 | TP53BP1 | S782 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12888 | TP53BP1 | S1435 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12888 | TP53BP1 | S1665 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q12906 | ILF3 | S744 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
Q13009 | TIAM1 | S298 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
Q13094 | LCP2 | S417 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
Q13200 | PSMD2 | S29 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
Q13409 | DYNC1I2 | S104 | ochoa | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
Q13428 | TCOF1 | S674 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q13443 | ADAM9 | S799 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
Q13501 | SQSTM1 | S226 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
Q13554 | CAMK2B | S395 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
Q13671 | RIN1 | S291 | ochoa|psp | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
Q13905 | RAPGEF1 | S313 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
Q14160 | SCRIB | S1353 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14566 | MCM6 | S268 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
Q14653 | IRF3 | S82 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
Q14686 | NCOA6 | S1238 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
Q14738 | PPP2R5D | S60 | ochoa|psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q14738 | PPP2R5D | S533 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q14814 | MEF2D | S472 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
Q14980 | NUMA1 | S1750 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q14980 | NUMA1 | S1947 | ochoa | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen) | Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. |
Q15415 | RBMY1F | S176 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}. |
Q15637 | SF1 | S89 | ochoa | Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269|PubMed:10449420, ECO:0000269|PubMed:8752089, ECO:0000269|PubMed:9660765}. |
Q15642 | TRIP10 | S506 | ochoa | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
Q15652 | JMJD1C | S943 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
Q15654 | TRIP6 | S156 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
Q15811 | ITSN1 | S313 | ochoa | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
Q15911 | ZFHX3 | S3418 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
Q15942 | ZYX | S143 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
Q16849 | PTPRN | S302 | ochoa | Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] | Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}. |
Q24JP5 | TMEM132A | S988 | ochoa | Transmembrane protein 132A (HSPA5-binding protein 1) | May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). {ECO:0000250}. |
Q3T8J9 | GON4L | S1436 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
Q53GL0 | PLEKHO1 | S271 | ochoa | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. {ECO:0000269|PubMed:14729969, ECO:0000269|PubMed:15706351, ECO:0000269|PubMed:15831458, ECO:0000269|PubMed:16325375, ECO:0000269|PubMed:16987810, ECO:0000269|PubMed:17197158, ECO:0000269|PubMed:17942896}. |
Q5T5Y3 | CAMSAP1 | S470 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
Q5T6C5 | ATXN7L2 | S477 | ochoa | Ataxin-7-like protein 2 | None |
Q5T6F2 | UBAP2 | S468 | ochoa | Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050). {ECO:0000269|PubMed:27121050, ECO:0000269|PubMed:35633597}. |
Q5THJ4 | VPS13D | S1727 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q5THJ4 | VPS13D | S2861 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
Q641Q2 | WASHC2A | S441 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q641Q2 | WASHC2A | S1123 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q66K74 | MAP1S | S929 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
Q6AI39 | BICRAL | S596 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
Q6IQ32 | ADNP2 | S1024 | ochoa | Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) | May be involved in transcriptional regulation. May play a role in neuronal function; perhaps involved in protection of brain tissues from oxidative stress. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CHC8}. |
Q6NUJ5 | PWWP2B | S456 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
Q6NXT4 | SLC30A6 | S388 | ochoa | Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) | Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). {ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:19759014, ECO:0000269|PubMed:35525268}. |
Q6PIY7 | TENT2 | S116 | psp | Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2) | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail (PubMed:15070731, PubMed:31792053). In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856, PubMed:31792053). {ECO:0000269|PubMed:15070731, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:23200856, ECO:0000269|PubMed:31792053}. |
Q6PJT7 | ZC3H14 | S132 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
Q6QNY0 | BLOC1S3 | S89 | ochoa | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
Q6RI45 | BRWD3 | S702 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
Q6UWD8 | C16orf54 | S92 | ochoa | Transmembrane protein C16orf54 | None |
Q6V0I7 | FAT4 | S4876 | ochoa | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}. |
Q6VUC0 | TFAP2E | S230 | ochoa | Transcription factor AP-2-epsilon (AP2-epsilon) (Activating enhancer-binding protein 2-epsilon) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}. |
Q6WCQ1 | MPRIP | S301 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
Q6WCQ1 | MPRIP | S663 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
Q6ZUT6 | CCDC9B | S210 | ochoa | Coiled-coil domain-containing protein 9B | None |
Q76N32 | CEP68 | S332 | psp | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
Q76N32 | CEP68 | S374 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
Q7KZI7 | MARK2 | S578 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
Q7L3V2 | RTL10 | S290 | ochoa | Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}. |
Q7L8J4 | SH3BP5L | S44 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
Q7LFL8 | CXXC5 | S62 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
Q7RTP6 | MICAL3 | S1300 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
Q7Z2K8 | GPRIN1 | S73 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z2T5 | TRMT1L | S71 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
Q7Z406 | MYH14 | S42 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
Q7Z5H3 | ARHGAP22 | S569 | ochoa | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
Q7Z5R6 | APBB1IP | S525 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
Q7Z6R9 | TFAP2D | S223 | ochoa | Transcription factor AP-2-delta (AP2-delta) (Activating enhancer-binding protein 2-delta) (Transcription factor AP-2-beta-like 1) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). {ECO:0000250}. |
Q86UR5 | RIMS1 | S713 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
Q86V48 | LUZP1 | S996 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
Q86WR7 | PROSER2 | S179 | ochoa | Proline and serine-rich protein 2 | None |
Q86X27 | RALGPS2 | S343 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
Q86YP4 | GATAD2A | S512 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
Q8IV50 | LYSMD2 | S31 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
Q8IV56 | PRR15 | S55 | ochoa | Proline-rich protein 15 | May have a role in proliferation and/or differentiation. {ECO:0000250}. |
Q8IX01 | SUGP2 | S754 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
Q8IX07 | ZFPM1 | S637 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
Q8IZ21 | PHACTR4 | S182 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
Q8IZW8 | TNS4 | S416 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
Q8N3V7 | SYNPO | S244 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N3V7 | SYNPO | S863 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N3V7 | SYNPO | S899 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N4S9 | MARVELD2 | S63 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
Q8N4S9 | MARVELD2 | Y137 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
Q8N884 | CGAS | S116 | ochoa|psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
Q8ND82 | ZNF280C | S114 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
Q8NFC6 | BOD1L1 | S980 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
Q8NFH8 | REPS2 | S240 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
Q8NFU5 | IPMK | S22 | ochoa | Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase) | Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) (By similarity). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:28882892, PubMed:30420721). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity). {ECO:0000250|UniProtKB:Q7TT16, ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481, ECO:0000269|PubMed:28882892, ECO:0000269|PubMed:29883610, ECO:0000269|PubMed:30420721, ECO:0000269|PubMed:30624931}. |
Q8NG31 | KNL1 | S629 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
Q8NI35 | PATJ | S1212 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
Q8TEW0 | PARD3 | S1335 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
Q8TF72 | SHROOM3 | S927 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
Q8WU20 | FRS2 | S155 | ochoa | Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1) | Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}. |
Q8WUB8 | PHF10 | S36 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
Q8WUF5 | PPP1R13L | S72 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
Q8WUI4 | HDAC7 | S507 | ochoa | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
Q8WXE0 | CASKIN2 | S800 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WXE1 | ATRIP | S38 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
Q8WYL5 | SSH1 | S744 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
Q92574 | TSC1 | S403 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
Q92619 | ARHGAP45 | S569 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
Q92667 | AKAP1 | S73 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
Q92667 | AKAP1 | S108 | ochoa | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250|UniProtKB:O08715, ECO:0000269|PubMed:31522117}. |
Q92754 | TFAP2C | S236 | ochoa | Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1) | Sequence-specific DNA-binding transcription factor that interacts with cellular enhancer elements to regulate transcription of selected genes, and which plays a key role in early embryonic development (PubMed:11694877, PubMed:24413532). AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (PubMed:11694877, PubMed:24413532). TFAP2C plays a key role in early embryonic development by regulating both inner cell mass (ICM) and trophectoderm differentiation (By similarity). At the 8-cell stage, during morula development, controls expression of cell-polarity genes (By similarity). Upon trophoblast commitment, binds to late trophectoderm genes in blastocysts together with CDX2, and later to extra-embryonic ectoderm genes together with SOX2 (By similarity). Binds to both closed and open chromatin with other transcription factors (By similarity). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:Q61312, ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:24413532}. |
Q92769 | HDAC2 | S394 | ochoa|psp | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (PubMed:12724404). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (PubMed:19343227). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A (PubMed:21965678). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:35044827). {ECO:0000250|UniProtKB:P70288, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:37137925}. |
Q92835 | INPP5D | S1059 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
Q93052 | LPP | S375 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
Q96BY7 | ATG2B | S493 | ochoa | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
Q96EC8 | YIPF6 | S24 | ochoa | Protein YIPF6 (YIP1 family member 6) | May be required for stable YIPF1 and YIPF2 protein expression. {ECO:0000269|PubMed:28286305}. |
Q96F45 | ZNF503 | S237 | ochoa | Zinc finger protein 503 | May function as a transcriptional repressor. {ECO:0000250}. |
Q96FF9 | CDCA5 | S33 | ochoa|psp | Sororin (Cell division cycle-associated protein 5) (p35) | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
Q96FS4 | SIPA1 | S912 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
Q96HZ4 | HES6 | S183 | psp | Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6) | Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}. |
Q96IJ6 | GMPPA | S373 | ochoa | Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex (PubMed:24035193, PubMed:33986552). Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose (PubMed:24035193, PubMed:33986552). Together with GMPPB regulates GDP-alpha-D-mannose levels (PubMed:33986552). {ECO:0000269|PubMed:24035193, ECO:0000269|PubMed:33986552}. |
Q96JM3 | CHAMP1 | S223 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96JM3 | CHAMP1 | S507 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96KG9 | SCYL1 | S754 | ochoa|psp | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
Q96KQ7 | EHMT2 | S211 | ochoa|psp | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000250|UniProtKB:Q9Z148, ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}. |
Q96KR1 | ZFR | S546 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
Q96L73 | NSD1 | S2341 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
Q96MH2 | HEXIM2 | S169 | ochoa | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
Q96RG2 | PASK | S106 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
Q96ST3 | SIN3A | S254 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
Q96SY0 | INTS14 | S387 | ochoa | Integrator complex subunit 14 (von Willebrand factor A domain-containing protein 9) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). {ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}. |
Q99501 | GAS2L1 | Y351 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
Q99700 | ATXN2 | S597 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
Q99700 | ATXN2 | S600 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
Q99941 | ATF6B | S564 | ochoa | Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] | [Cyclic AMP-dependent transcription factor ATF-6 beta]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944). {ECO:0000269|PubMed:11256944}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944). {ECO:0000269|PubMed:11256944}. |
Q9BQE5 | APOL2 | S250 | ochoa | Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II) | May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. |
Q9BRK4 | LZTS2 | S276 | ochoa | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}. |
Q9BUK6 | MSTO1 | S495 | ochoa | Protein misato homolog 1 | Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28544275, PubMed:28554942). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28544275, PubMed:28554942). {ECO:0000269|PubMed:17349998, ECO:0000269|PubMed:28544275, ECO:0000269|PubMed:28554942}. |
Q9BX66 | SORBS1 | S452 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
Q9BXF3 | CECR2 | S1306 | ochoa | Chromatin remodeling regulator CECR2 (Cat eye syndrome critical region protein 2) | Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15640247, PubMed:22464331, PubMed:26365797, PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed:28801535). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:22464331, PubMed:26365797). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465). {ECO:0000250|UniProtKB:E9Q2Z1, ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15640247, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:28801535}. |
Q9C0C2 | TNKS1BP1 | S315 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9C0C9 | UBE2O | S50 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
Q9C0H5 | ARHGAP39 | S253 | ochoa | Rho GTPase-activating protein 39 | None |
Q9GZN7 | ROGDI | S227 | ochoa | Protein rogdi homolog | None |
Q9H211 | CDT1 | S73 | ochoa | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
Q9H2Y7 | ZNF106 | S509 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H3T3 | SEMA6B | S748 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
Q9H6I2 | SOX17 | S349 | ochoa | Transcription factor SOX-17 | Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. {ECO:0000250|UniProtKB:Q61473}. |
Q9H792 | PEAK1 | S792 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9H7N4 | SCAF1 | S734 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9H7N4 | SCAF1 | S819 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9H987 | SYNPO2L | S615 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
Q9HCM7 | FBRSL1 | S1017 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
Q9NP61 | ARFGAP3 | S211 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
Q9NQS1 | AVEN | S268 | ochoa | Cell death regulator Aven | Protects against apoptosis mediated by Apaf-1. |
Q9NQS7 | INCENP | S323 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
Q9NTJ3 | SMC4 | S50 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
Q9NUE0 | ZDHHC18 | S53 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
Q9P206 | NHSL3 | S912 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9UEG4 | ZNF629 | S625 | ochoa | Zinc finger protein 629 (Zinc finger protein 65) | May be involved in transcriptional regulation. |
Q9UF83 | None | S519 | ochoa | Uncharacterized protein DKFZp434B061 | None |
Q9UHB6 | LIMA1 | S371 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
Q9UHG2 | PCSK1N | S44 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
Q9UHW9 | SLC12A6 | S93 | ochoa | Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) | [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}. |
Q9UJY1 | HSPB8 | S57 | ochoa|psp | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22) | Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250|UniProtKB:Q9JK92}. |
Q9UK61 | TASOR | S971 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
Q9UKF7 | PITPNC1 | S270 | ochoa | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta) | [Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16:0/16:1 and C16:1/18:1 PA species (PubMed:22822086). {ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:22822086}.; FUNCTION: [Isoform 2]: Catalyzes the transfer of phosphatidylinositol between membranes. {ECO:0000269|PubMed:22822086}. |
Q9UKK3 | PARP4 | S1223 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
Q9ULL8 | SHROOM4 | S282 | ochoa | Protein Shroom4 (Second homolog of apical protein) | Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity). {ECO:0000250, ECO:0000269|PubMed:16684770}. |
Q9ULT8 | HECTD1 | S1543 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
Q9UMS6 | SYNPO2 | S805 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UPS6 | SETD1B | S1431 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
Q9Y242 | TCF19 | S167 | ochoa | Transcription factor 19 (TCF-19) (Transcription factor SC1) | Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition (PubMed:1868030, PubMed:31141247). May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1 (PubMed:31141247). {ECO:0000269|PubMed:1868030, ECO:0000269|PubMed:31141247}. |
Q9Y250 | LZTS1 | S140 | ochoa | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}. |
Q9Y2G1 | MYRF | S148 | ochoa | Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal] | [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269|PubMed:23966832}.; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832). {ECO:0000269|PubMed:23966832}. |
Q9Y2I7 | PIKFYVE | S85 | ochoa | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
Q9Y2T7 | YBX2 | S74 | ochoa | Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) | Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250|UniProtKB:Q9Z2C8}. |
Q9Y4B5 | MTCL1 | S192 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
Q9Y4H2 | IRS2 | S1109 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y5S2 | CDC42BPB | S1640 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
Q9Y617 | PSAT1 | S20 | ochoa | Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) | Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. {ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284}. |
Q9Y6I3 | EPN1 | S473 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
Q01082 | SPTBN1 | S2197 | Sugiyama | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
P47756 | CAPZB | S90 | Sugiyama | F-actin-capping protein subunit beta (CapZ beta) | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}. |
Q15759 | MAPK11 | S37 | Sugiyama | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
P29144 | TPP2 | S25 | Sugiyama | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (PubMed:25525876, PubMed:30533531). It plays an important role in intracellular amino acid homeostasis (PubMed:25525876). Stimulates adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q64514, ECO:0000269|PubMed:25525876, ECO:0000269|PubMed:30533531}. |
Q8TD08 | MAPK15 | S505 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
Q9UQ07 | MOK | S321 | Sugiyama | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.148155e-07 | 6.502 |
R-HSA-166520 | Signaling by NTRKs | 3.248676e-07 | 6.488 |
R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 1.760320e-06 | 5.754 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.412286e-05 | 4.850 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 4.218843e-05 | 4.375 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.022368e-05 | 4.396 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.619179e-05 | 4.250 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 6.560548e-05 | 4.183 |
R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 6.560548e-05 | 4.183 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 7.267335e-05 | 4.139 |
R-HSA-1500931 | Cell-Cell communication | 1.034669e-04 | 3.985 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.182768e-04 | 3.927 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.250968e-04 | 3.903 |
R-HSA-1266695 | Interleukin-7 signaling | 2.359285e-04 | 3.627 |
R-HSA-446728 | Cell junction organization | 2.770974e-04 | 3.557 |
R-HSA-421270 | Cell-cell junction organization | 3.410254e-04 | 3.467 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.585471e-04 | 3.339 |
R-HSA-9031628 | NGF-stimulated transcription | 4.986883e-04 | 3.302 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 5.444666e-04 | 3.264 |
R-HSA-9827857 | Specification of primordial germ cells | 6.469920e-04 | 3.189 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 7.807551e-04 | 3.107 |
R-HSA-162582 | Signal Transduction | 8.206914e-04 | 3.086 |
R-HSA-418990 | Adherens junctions interactions | 1.095754e-03 | 2.960 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.440702e-03 | 2.841 |
R-HSA-141424 | Amplification of signal from the kinetochores | 1.440702e-03 | 2.841 |
R-HSA-1257604 | PIP3 activates AKT signaling | 1.432329e-03 | 2.844 |
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 1.565293e-03 | 2.805 |
R-HSA-3214841 | PKMTs methylate histone lysines | 1.654566e-03 | 2.781 |
R-HSA-212436 | Generic Transcription Pathway | 2.057592e-03 | 2.687 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.036261e-03 | 2.691 |
R-HSA-9006925 | Intracellular signaling by second messengers | 1.927262e-03 | 2.715 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 2.283935e-03 | 2.641 |
R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 3.555937e-03 | 2.449 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.781957e-03 | 2.556 |
R-HSA-170968 | Frs2-mediated activation | 3.425311e-03 | 2.465 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.007084e-03 | 2.522 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 3.604672e-03 | 2.443 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 3.477540e-03 | 2.459 |
R-HSA-4839726 | Chromatin organization | 2.981275e-03 | 2.526 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 2.530085e-03 | 2.597 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.193956e-03 | 2.496 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.966169e-03 | 2.528 |
R-HSA-73857 | RNA Polymerase II Transcription | 3.504974e-03 | 2.455 |
R-HSA-69620 | Cell Cycle Checkpoints | 3.863537e-03 | 2.413 |
R-HSA-68877 | Mitotic Prometaphase | 4.428206e-03 | 2.354 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.255858e-03 | 2.371 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 4.307986e-03 | 2.366 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.062402e-03 | 2.296 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 5.062402e-03 | 2.296 |
R-HSA-2467813 | Separation of Sister Chromatids | 5.046265e-03 | 2.297 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 4.777846e-03 | 2.321 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.462438e-03 | 2.263 |
R-HSA-169893 | Prolonged ERK activation events | 5.369009e-03 | 2.270 |
R-HSA-5683057 | MAPK family signaling cascades | 5.517577e-03 | 2.258 |
R-HSA-193648 | NRAGE signals death through JNK | 5.580240e-03 | 2.253 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.706211e-03 | 2.244 |
R-HSA-74713 | IRS activation | 6.812358e-03 | 2.167 |
R-HSA-187687 | Signalling to ERKs | 6.564543e-03 | 2.183 |
R-HSA-450294 | MAP kinase activation | 7.584263e-03 | 2.120 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 7.148649e-03 | 2.146 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.958038e-03 | 2.225 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 6.564543e-03 | 2.183 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 5.958038e-03 | 2.225 |
R-HSA-74160 | Gene expression (Transcription) | 7.744719e-03 | 2.111 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 8.797021e-03 | 2.056 |
R-HSA-9834899 | Specification of the neural plate border | 8.819422e-03 | 2.055 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 1.116178e-02 | 1.952 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.032561e-02 | 1.986 |
R-HSA-198753 | ERK/MAPK targets | 1.093344e-02 | 1.961 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.081083e-02 | 1.966 |
R-HSA-201556 | Signaling by ALK | 8.953789e-03 | 2.048 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.241569e-03 | 2.034 |
R-HSA-73887 | Death Receptor Signaling | 1.125086e-02 | 1.949 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.209068e-02 | 1.918 |
R-HSA-448424 | Interleukin-17 signaling | 1.236412e-02 | 1.908 |
R-HSA-112412 | SOS-mediated signalling | 1.343648e-02 | 1.872 |
R-HSA-350054 | Notch-HLH transcription pathway | 1.331561e-02 | 1.876 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.365137e-02 | 1.865 |
R-HSA-9022707 | MECP2 regulates transcription factors | 1.343648e-02 | 1.872 |
R-HSA-199991 | Membrane Trafficking | 1.401246e-02 | 1.853 |
R-HSA-3247509 | Chromatin modifying enzymes | 1.447383e-02 | 1.839 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.275338e-02 | 1.894 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.275338e-02 | 1.894 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.275338e-02 | 1.894 |
R-HSA-1266738 | Developmental Biology | 1.531044e-02 | 1.815 |
R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.891501e-02 | 1.723 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.740142e-02 | 1.759 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.740142e-02 | 1.759 |
R-HSA-525793 | Myogenesis | 1.890154e-02 | 1.724 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.945044e-02 | 1.711 |
R-HSA-449147 | Signaling by Interleukins | 1.906343e-02 | 1.720 |
R-HSA-416482 | G alpha (12/13) signalling events | 1.804663e-02 | 1.744 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.015844e-02 | 1.696 |
R-HSA-5673001 | RAF/MAP kinase cascade | 2.067536e-02 | 1.685 |
R-HSA-9762292 | Regulation of CDH11 function | 2.194930e-02 | 1.659 |
R-HSA-198203 | PI3K/AKT activation | 2.194930e-02 | 1.659 |
R-HSA-74749 | Signal attenuation | 2.194930e-02 | 1.659 |
R-HSA-2586552 | Signaling by Leptin | 2.194930e-02 | 1.659 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.268282e-02 | 1.644 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.316543e-02 | 1.635 |
R-HSA-68882 | Mitotic Anaphase | 2.366953e-02 | 1.626 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.384402e-02 | 1.623 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.423139e-02 | 1.616 |
R-HSA-209560 | NF-kB is activated and signals survival | 2.857051e-02 | 1.544 |
R-HSA-9734767 | Developmental Cell Lineages | 2.782709e-02 | 1.556 |
R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.517023e-02 | 1.599 |
R-HSA-182971 | EGFR downregulation | 2.744516e-02 | 1.562 |
R-HSA-9758941 | Gastrulation | 2.815642e-02 | 1.550 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.560897e-02 | 1.592 |
R-HSA-9856651 | MITF-M-dependent gene expression | 2.894342e-02 | 1.538 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.431841e-02 | 1.614 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.912592e-02 | 1.536 |
R-HSA-69278 | Cell Cycle, Mitotic | 2.922776e-02 | 1.534 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 3.005232e-02 | 1.522 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 3.005232e-02 | 1.522 |
R-HSA-1640170 | Cell Cycle | 3.117488e-02 | 1.506 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.134839e-02 | 1.504 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.134839e-02 | 1.504 |
R-HSA-168898 | Toll-like Receptor Cascades | 3.205543e-02 | 1.494 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 3.294678e-02 | 1.482 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 3.294678e-02 | 1.482 |
R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.340331e-02 | 1.476 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 3.341451e-02 | 1.476 |
R-HSA-2682334 | EPH-Ephrin signaling | 3.403299e-02 | 1.468 |
R-HSA-5673000 | RAF activation | 3.552666e-02 | 1.449 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 3.588093e-02 | 1.445 |
R-HSA-9675108 | Nervous system development | 3.622230e-02 | 1.441 |
R-HSA-5633007 | Regulation of TP53 Activity | 3.764143e-02 | 1.424 |
R-HSA-9027284 | Erythropoietin activates RAS | 4.382607e-02 | 1.358 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.971949e-02 | 1.401 |
R-HSA-193639 | p75NTR signals via NF-kB | 4.382607e-02 | 1.358 |
R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.997701e-02 | 1.398 |
R-HSA-6807878 | COPI-mediated anterograde transport | 4.039143e-02 | 1.394 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 4.382607e-02 | 1.358 |
R-HSA-212165 | Epigenetic regulation of gene expression | 3.941610e-02 | 1.404 |
R-HSA-2428924 | IGF1R signaling cascade | 3.808404e-02 | 1.419 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 4.382607e-02 | 1.358 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.971949e-02 | 1.401 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.977746e-02 | 1.400 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.715421e-02 | 1.326 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 4.357997e-02 | 1.361 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 4.802042e-02 | 1.319 |
R-HSA-9664420 | Killing mechanisms | 4.802042e-02 | 1.319 |
R-HSA-9842860 | Regulation of endogenous retroelements | 4.891381e-02 | 1.311 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.967810e-02 | 1.304 |
R-HSA-5619039 | Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... | 5.083161e-02 | 1.294 |
R-HSA-9635644 | Inhibition of membrane repair | 5.083161e-02 | 1.294 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 5.197289e-02 | 1.284 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.226667e-02 | 1.282 |
R-HSA-9675151 | Disorders of Developmental Biology | 5.235432e-02 | 1.281 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.484438e-02 | 1.261 |
R-HSA-9656223 | Signaling by RAF1 mutants | 5.491921e-02 | 1.260 |
R-HSA-2028269 | Signaling by Hippo | 5.682174e-02 | 1.245 |
R-HSA-6807070 | PTEN Regulation | 5.684058e-02 | 1.245 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.763500e-02 | 1.239 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 6.141684e-02 | 1.212 |
R-HSA-156711 | Polo-like kinase mediated events | 6.141684e-02 | 1.212 |
R-HSA-3928662 | EPHB-mediated forward signaling | 6.325323e-02 | 1.199 |
R-HSA-1834941 | STING mediated induction of host immune responses | 6.613392e-02 | 1.180 |
R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 6.719667e-02 | 1.173 |
R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 6.719667e-02 | 1.173 |
R-HSA-68881 | Mitotic Metaphase/Anaphase Transition | 6.719667e-02 | 1.173 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 8.328057e-02 | 1.079 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 8.328057e-02 | 1.079 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 7.096744e-02 | 1.149 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 8.096242e-02 | 1.092 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.911489e-02 | 1.160 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.911489e-02 | 1.160 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 6.911489e-02 | 1.160 |
R-HSA-6802957 | Oncogenic MAPK signaling | 8.062551e-02 | 1.094 |
R-HSA-6802949 | Signaling by RAS mutants | 6.911489e-02 | 1.160 |
R-HSA-8985801 | Regulation of cortical dendrite branching | 6.719667e-02 | 1.173 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 8.328057e-02 | 1.079 |
R-HSA-8875513 | MET interacts with TNS proteins | 8.328057e-02 | 1.079 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 8.096242e-02 | 1.092 |
R-HSA-68949 | Orc1 removal from chromatin | 8.808988e-02 | 1.055 |
R-HSA-373753 | Nephrin family interactions | 7.096744e-02 | 1.149 |
R-HSA-9823730 | Formation of definitive endoderm | 7.096744e-02 | 1.149 |
R-HSA-5653656 | Vesicle-mediated transport | 8.903447e-02 | 1.050 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 8.062551e-02 | 1.094 |
R-HSA-109704 | PI3K Cascade | 8.154062e-02 | 1.089 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 8.808988e-02 | 1.055 |
R-HSA-9711123 | Cellular response to chemical stress | 6.683279e-02 | 1.175 |
R-HSA-446652 | Interleukin-1 family signaling | 7.848191e-02 | 1.105 |
R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 8.611357e-02 | 1.065 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 7.834866e-02 | 1.106 |
R-HSA-9663891 | Selective autophagy | 9.061309e-02 | 1.043 |
R-HSA-982772 | Growth hormone receptor signaling | 9.136051e-02 | 1.039 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 9.144523e-02 | 1.039 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 9.278732e-02 | 1.033 |
R-HSA-9652169 | Signaling by MAP2K mutants | 9.908812e-02 | 1.004 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.298930e-01 | 0.886 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.298930e-01 | 0.886 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.448995e-01 | 0.839 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 1.448995e-01 | 0.839 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.448995e-01 | 0.839 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 1.596482e-01 | 0.797 |
R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.596482e-01 | 0.797 |
R-HSA-110056 | MAPK3 (ERK1) activation | 2.023905e-01 | 0.694 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.023905e-01 | 0.694 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.161509e-01 | 0.665 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.161509e-01 | 0.665 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.161509e-01 | 0.665 |
R-HSA-429947 | Deadenylation of mRNA | 9.669843e-02 | 1.015 |
R-HSA-428540 | Activation of RAC1 | 2.296748e-01 | 0.639 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.296748e-01 | 0.639 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 2.296748e-01 | 0.639 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.429662e-01 | 0.614 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.429662e-01 | 0.614 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.429662e-01 | 0.614 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.429662e-01 | 0.614 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.429662e-01 | 0.614 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.429662e-01 | 0.614 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.429662e-01 | 0.614 |
R-HSA-9006335 | Signaling by Erythropoietin | 1.245941e-01 | 0.905 |
R-HSA-68962 | Activation of the pre-replicative complex | 1.303845e-01 | 0.885 |
R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.814847e-01 | 0.551 |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.814847e-01 | 0.551 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.814847e-01 | 0.551 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.601768e-01 | 0.795 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.163448e-01 | 0.934 |
R-HSA-5674135 | MAP2K and MAPK activation | 2.099323e-01 | 0.678 |
R-HSA-8854518 | AURKA Activation by TPX2 | 1.394630e-01 | 0.856 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 2.162687e-01 | 0.665 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.390042e-01 | 0.622 |
R-HSA-9018519 | Estrogen-dependent gene expression | 2.768332e-01 | 0.558 |
R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 1.421444e-01 | 0.847 |
R-HSA-191650 | Regulation of gap junction activity | 9.908812e-02 | 1.004 |
R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 1.596482e-01 | 0.797 |
R-HSA-190873 | Gap junction degradation | 1.883894e-01 | 0.725 |
R-HSA-9796292 | Formation of axial mesoderm | 2.560290e-01 | 0.592 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.724196e-01 | 0.763 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 2.737837e-01 | 0.563 |
R-HSA-9620244 | Long-term potentiation | 1.021227e-01 | 0.991 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 2.429662e-01 | 0.614 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 2.417604e-01 | 0.617 |
R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.146240e-01 | 0.941 |
R-HSA-420029 | Tight junction interactions | 1.021227e-01 | 0.991 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 1.662783e-01 | 0.779 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.785975e-01 | 0.748 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.162668e-01 | 0.665 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.688672e-01 | 0.570 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.073050e-01 | 0.683 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 9.908812e-02 | 1.004 |
R-HSA-176417 | Phosphorylation of Emi1 | 1.298930e-01 | 0.886 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 1.448995e-01 | 0.839 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.596482e-01 | 0.797 |
R-HSA-196025 | Formation of annular gap junctions | 1.741433e-01 | 0.759 |
R-HSA-176974 | Unwinding of DNA | 1.883894e-01 | 0.725 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.883894e-01 | 0.725 |
R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.023905e-01 | 0.694 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 2.023905e-01 | 0.694 |
R-HSA-192814 | vRNA Synthesis | 2.161509e-01 | 0.665 |
R-HSA-4839744 | Signaling by APC mutants | 2.161509e-01 | 0.665 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 2.296748e-01 | 0.639 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.296748e-01 | 0.639 |
R-HSA-202670 | ERKs are inactivated | 2.296748e-01 | 0.639 |
R-HSA-4839748 | Signaling by AMER1 mutants | 2.296748e-01 | 0.639 |
R-HSA-4839735 | Signaling by AXIN mutants | 2.296748e-01 | 0.639 |
R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 2.560290e-01 | 0.592 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.814847e-01 | 0.551 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.601768e-01 | 0.795 |
R-HSA-69052 | Switching of origins to a post-replicative state | 1.681810e-01 | 0.774 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.737837e-01 | 0.563 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 2.688672e-01 | 0.570 |
R-HSA-209543 | p75NTR recruits signalling complexes | 2.429662e-01 | 0.614 |
R-HSA-176187 | Activation of ATR in response to replication stress | 1.481064e-01 | 0.829 |
R-HSA-112399 | IRS-mediated signalling | 1.053813e-01 | 0.977 |
R-HSA-69275 | G2/M Transition | 1.497818e-01 | 0.825 |
R-HSA-1474165 | Reproduction | 2.502632e-01 | 0.602 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.598037e-01 | 0.796 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.353703e-01 | 0.628 |
R-HSA-453274 | Mitotic G2-G2/M phases | 1.545369e-01 | 0.811 |
R-HSA-418885 | DCC mediated attractive signaling | 2.814847e-01 | 0.551 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.596482e-01 | 0.797 |
R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.023905e-01 | 0.694 |
R-HSA-1855191 | Synthesis of IPs in the nucleus | 2.688672e-01 | 0.570 |
R-HSA-171007 | p38MAPK events | 2.814847e-01 | 0.551 |
R-HSA-74751 | Insulin receptor signalling cascade | 1.315904e-01 | 0.881 |
R-HSA-68886 | M Phase | 9.634284e-02 | 1.016 |
R-HSA-68867 | Assembly of the pre-replicative complex | 2.667815e-01 | 0.574 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.560290e-01 | 0.592 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 1.973208e-01 | 0.705 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 1.973208e-01 | 0.705 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.359427e-01 | 0.867 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 9.908812e-02 | 1.004 |
R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.298930e-01 | 0.886 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 1.298930e-01 | 0.886 |
R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 2.023905e-01 | 0.694 |
R-HSA-177504 | Retrograde neurotrophin signalling | 2.688672e-01 | 0.570 |
R-HSA-9646399 | Aggrephagy | 1.973208e-01 | 0.705 |
R-HSA-69481 | G2/M Checkpoints | 2.353384e-01 | 0.628 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.761286e-01 | 0.559 |
R-HSA-9664873 | Pexophagy | 2.023905e-01 | 0.694 |
R-HSA-202403 | TCR signaling | 1.647702e-01 | 0.783 |
R-HSA-9842663 | Signaling by LTK | 2.429662e-01 | 0.614 |
R-HSA-446353 | Cell-extracellular matrix interactions | 2.814847e-01 | 0.551 |
R-HSA-9733709 | Cardiogenesis | 1.481064e-01 | 0.829 |
R-HSA-74752 | Signaling by Insulin receptor | 2.621223e-01 | 0.581 |
R-HSA-2559583 | Cellular Senescence | 1.359268e-01 | 0.867 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.448995e-01 | 0.839 |
R-HSA-205043 | NRIF signals cell death from the nucleus | 2.688672e-01 | 0.570 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 9.831236e-02 | 1.007 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 1.598037e-01 | 0.796 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 1.556645e-01 | 0.808 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.296748e-01 | 0.639 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.973208e-01 | 0.705 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.353703e-01 | 0.628 |
R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.298930e-01 | 0.886 |
R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.448995e-01 | 0.839 |
R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.596482e-01 | 0.797 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 2.023905e-01 | 0.694 |
R-HSA-446205 | Synthesis of GDP-mannose | 2.429662e-01 | 0.614 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.188686e-01 | 0.925 |
R-HSA-8875878 | MET promotes cell motility | 1.848089e-01 | 0.733 |
R-HSA-453276 | Regulation of mitotic cell cycle | 1.598037e-01 | 0.796 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.598037e-01 | 0.796 |
R-HSA-157858 | Gap junction trafficking and regulation | 2.609681e-01 | 0.583 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.984310e-01 | 0.702 |
R-HSA-3371571 | HSF1-dependent transactivation | 2.737837e-01 | 0.563 |
R-HSA-9843745 | Adipogenesis | 2.540262e-01 | 0.595 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 1.851034e-01 | 0.733 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.023905e-01 | 0.694 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 1.394630e-01 | 0.856 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.353703e-01 | 0.628 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.578009e-01 | 0.589 |
R-HSA-69242 | S Phase | 1.650920e-01 | 0.782 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.785975e-01 | 0.748 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.132121e-01 | 0.946 |
R-HSA-202424 | Downstream TCR signaling | 2.482123e-01 | 0.605 |
R-HSA-438064 | Post NMDA receptor activation events | 2.344226e-01 | 0.630 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.146240e-01 | 0.941 |
R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.146240e-01 | 0.941 |
R-HSA-448706 | Interleukin-1 processing | 1.883894e-01 | 0.725 |
R-HSA-193692 | Regulated proteolysis of p75NTR | 1.883894e-01 | 0.725 |
R-HSA-111458 | Formation of apoptosome | 2.023905e-01 | 0.694 |
R-HSA-9005895 | Pervasive developmental disorders | 2.429662e-01 | 0.614 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.429662e-01 | 0.614 |
R-HSA-9697154 | Disorders of Nervous System Development | 2.429662e-01 | 0.614 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.688672e-01 | 0.570 |
R-HSA-9766229 | Degradation of CDH1 | 2.609681e-01 | 0.583 |
R-HSA-69206 | G1/S Transition | 2.279593e-01 | 0.642 |
R-HSA-2132295 | MHC class II antigen presentation | 2.170058e-01 | 0.664 |
R-HSA-1169408 | ISG15 antiviral mechanism | 1.766834e-01 | 0.753 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.353703e-01 | 0.628 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.353703e-01 | 0.628 |
R-HSA-5205647 | Mitophagy | 1.601768e-01 | 0.795 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.662783e-01 | 0.779 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.481064e-01 | 0.829 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 2.763095e-01 | 0.559 |
R-HSA-9627069 | Regulation of the apoptosome activity | 2.023905e-01 | 0.694 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.296748e-01 | 0.639 |
R-HSA-422475 | Axon guidance | 1.203317e-01 | 0.920 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 2.036154e-01 | 0.691 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.639762e-01 | 0.785 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 1.622941e-01 | 0.790 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 1.735997e-01 | 0.760 |
R-HSA-9020702 | Interleukin-1 signaling | 1.328764e-01 | 0.877 |
R-HSA-1632852 | Macroautophagy | 1.432698e-01 | 0.844 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.023905e-01 | 0.694 |
R-HSA-210990 | PECAM1 interactions | 2.161509e-01 | 0.665 |
R-HSA-2262752 | Cellular responses to stress | 9.671177e-02 | 1.015 |
R-HSA-177929 | Signaling by EGFR | 1.018221e-01 | 0.992 |
R-HSA-165159 | MTOR signalling | 2.162687e-01 | 0.665 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 2.117754e-01 | 0.674 |
R-HSA-8953897 | Cellular responses to stimuli | 1.641730e-01 | 0.785 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.549249e-01 | 0.810 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.429662e-01 | 0.614 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.688672e-01 | 0.570 |
R-HSA-186763 | Downstream signal transduction | 1.362358e-01 | 0.866 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.814847e-01 | 0.551 |
R-HSA-9612973 | Autophagy | 1.881425e-01 | 0.726 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 2.099323e-01 | 0.678 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.298571e-01 | 0.639 |
R-HSA-9700206 | Signaling by ALK in cancer | 1.549249e-01 | 0.810 |
R-HSA-9683610 | Maturation of nucleoprotein | 2.560290e-01 | 0.592 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.741433e-01 | 0.759 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.741433e-01 | 0.759 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.560290e-01 | 0.592 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 1.809788e-01 | 0.742 |
R-HSA-186797 | Signaling by PDGF | 1.238815e-01 | 0.907 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.145788e-01 | 0.941 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 9.669843e-02 | 1.015 |
R-HSA-8863678 | Neurodegenerative Diseases | 9.669843e-02 | 1.015 |
R-HSA-9909396 | Circadian clock | 2.578009e-01 | 0.589 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.556645e-01 | 0.808 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.205753e-01 | 0.919 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.205753e-01 | 0.919 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.132121e-01 | 0.946 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 1.481064e-01 | 0.829 |
R-HSA-8853659 | RET signaling | 1.724196e-01 | 0.763 |
R-HSA-1592230 | Mitochondrial biogenesis | 1.955642e-01 | 0.709 |
R-HSA-9707616 | Heme signaling | 1.238815e-01 | 0.907 |
R-HSA-909733 | Interferon alpha/beta signaling | 1.885697e-01 | 0.725 |
R-HSA-6806834 | Signaling by MET | 1.984310e-01 | 0.702 |
R-HSA-9008059 | Interleukin-37 signaling | 1.303845e-01 | 0.885 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 1.481064e-01 | 0.829 |
R-HSA-69205 | G1/S-Specific Transcription | 1.724196e-01 | 0.763 |
R-HSA-73864 | RNA Polymerase I Transcription | 1.896529e-01 | 0.722 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 2.028565e-01 | 0.693 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.099323e-01 | 0.678 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 2.097863e-01 | 0.678 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.162687e-01 | 0.665 |
R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 2.560290e-01 | 0.592 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 1.163448e-01 | 0.934 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 1.163448e-01 | 0.934 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 1.163448e-01 | 0.934 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 1.163448e-01 | 0.934 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.474906e-01 | 0.831 |
R-HSA-9678108 | SARS-CoV-1 Infection | 2.501588e-01 | 0.602 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 2.099323e-01 | 0.678 |
R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 2.688672e-01 | 0.570 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 1.163448e-01 | 0.934 |
R-HSA-1980143 | Signaling by NOTCH1 | 1.809788e-01 | 0.742 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.902079e-01 | 0.537 |
R-HSA-8939211 | ESR-mediated signaling | 2.910033e-01 | 0.536 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.938852e-01 | 0.532 |
R-HSA-176412 | Phosphorylation of the APC/C | 2.938852e-01 | 0.532 |
R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.938852e-01 | 0.532 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 2.938852e-01 | 0.532 |
R-HSA-3214815 | HDACs deacetylate histones | 2.993718e-01 | 0.524 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 3.057497e-01 | 0.515 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.060724e-01 | 0.514 |
R-HSA-9690406 | Transcriptional regulation of testis differentiation | 3.060724e-01 | 0.514 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.060724e-01 | 0.514 |
R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.060724e-01 | 0.514 |
R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.060724e-01 | 0.514 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.090559e-01 | 0.510 |
R-HSA-9764561 | Regulation of CDH1 Function | 3.121168e-01 | 0.506 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.121168e-01 | 0.506 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.137762e-01 | 0.503 |
R-HSA-1483255 | PI Metabolism | 3.137762e-01 | 0.503 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.180500e-01 | 0.498 |
R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.180500e-01 | 0.498 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 3.180500e-01 | 0.498 |
R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 3.180500e-01 | 0.498 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.184714e-01 | 0.497 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.193995e-01 | 0.496 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.248122e-01 | 0.488 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 3.279446e-01 | 0.484 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.279446e-01 | 0.484 |
R-HSA-3928664 | Ephrin signaling | 3.298216e-01 | 0.482 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.298216e-01 | 0.482 |
R-HSA-73980 | RNA Polymerase III Transcription Termination | 3.298216e-01 | 0.482 |
R-HSA-432142 | Platelet sensitization by LDL | 3.298216e-01 | 0.482 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 3.298216e-01 | 0.482 |
R-HSA-111471 | Apoptotic factor-mediated response | 3.298216e-01 | 0.482 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.311377e-01 | 0.480 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 3.373894e-01 | 0.472 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 3.374467e-01 | 0.472 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.402607e-01 | 0.468 |
R-HSA-5654710 | PI-3K cascade:FGFR3 | 3.413907e-01 | 0.467 |
R-HSA-392517 | Rap1 signalling | 3.413907e-01 | 0.467 |
R-HSA-912631 | Regulation of signaling by CBL | 3.413907e-01 | 0.467 |
R-HSA-9694631 | Maturation of nucleoprotein | 3.413907e-01 | 0.467 |
R-HSA-844456 | The NLRP3 inflammasome | 3.413907e-01 | 0.467 |
R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 3.413907e-01 | 0.467 |
R-HSA-69239 | Synthesis of DNA | 3.421094e-01 | 0.466 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.428502e-01 | 0.465 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.437376e-01 | 0.464 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 3.437376e-01 | 0.464 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 3.437376e-01 | 0.464 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.500095e-01 | 0.456 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.500095e-01 | 0.456 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.500095e-01 | 0.456 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.506818e-01 | 0.455 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.506818e-01 | 0.455 |
R-HSA-69002 | DNA Replication Pre-Initiation | 3.515415e-01 | 0.454 |
R-HSA-5654720 | PI-3K cascade:FGFR4 | 3.527608e-01 | 0.453 |
R-HSA-389513 | Co-inhibition by CTLA4 | 3.527608e-01 | 0.453 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 3.527608e-01 | 0.453 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.527608e-01 | 0.453 |
R-HSA-445144 | Signal transduction by L1 | 3.527608e-01 | 0.453 |
R-HSA-6807004 | Negative regulation of MET activity | 3.527608e-01 | 0.453 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.562609e-01 | 0.448 |
R-HSA-1234174 | Cellular response to hypoxia | 3.624908e-01 | 0.441 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.639353e-01 | 0.439 |
R-HSA-167044 | Signalling to RAS | 3.639353e-01 | 0.439 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.639353e-01 | 0.439 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 3.639353e-01 | 0.439 |
R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.639353e-01 | 0.439 |
R-HSA-1483249 | Inositol phosphate metabolism | 3.656596e-01 | 0.437 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 3.749176e-01 | 0.426 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.749176e-01 | 0.426 |
R-HSA-977347 | Serine metabolism | 3.749176e-01 | 0.426 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.749176e-01 | 0.426 |
R-HSA-8949215 | Mitochondrial calcium ion transport | 3.749176e-01 | 0.426 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.749176e-01 | 0.426 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 3.793983e-01 | 0.421 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.810402e-01 | 0.419 |
R-HSA-5654689 | PI-3K cascade:FGFR1 | 3.857109e-01 | 0.414 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 3.857109e-01 | 0.414 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.857109e-01 | 0.414 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.857109e-01 | 0.414 |
R-HSA-166208 | mTORC1-mediated signalling | 3.857109e-01 | 0.414 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.857109e-01 | 0.414 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 3.871733e-01 | 0.412 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.890688e-01 | 0.410 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 3.932796e-01 | 0.405 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.932796e-01 | 0.405 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.932796e-01 | 0.405 |
R-HSA-373760 | L1CAM interactions | 3.937272e-01 | 0.405 |
R-HSA-912526 | Interleukin receptor SHC signaling | 3.963185e-01 | 0.402 |
R-HSA-9007101 | Rab regulation of trafficking | 3.983764e-01 | 0.400 |
R-HSA-5693538 | Homology Directed Repair | 4.030161e-01 | 0.395 |
R-HSA-913531 | Interferon Signaling | 4.050173e-01 | 0.393 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.054087e-01 | 0.392 |
R-HSA-9865881 | Complex III assembly | 4.067435e-01 | 0.391 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.067435e-01 | 0.391 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.067435e-01 | 0.391 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.067435e-01 | 0.391 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 4.076456e-01 | 0.390 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 4.114297e-01 | 0.386 |
R-HSA-68875 | Mitotic Prophase | 4.122644e-01 | 0.385 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.169892e-01 | 0.380 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 4.169892e-01 | 0.380 |
R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.169892e-01 | 0.380 |
R-HSA-3214842 | HDMs demethylate histones | 4.169892e-01 | 0.380 |
R-HSA-400685 | Sema4D in semaphorin signaling | 4.169892e-01 | 0.380 |
R-HSA-69473 | G2/M DNA damage checkpoint | 4.174207e-01 | 0.379 |
R-HSA-1236394 | Signaling by ERBB4 | 4.174207e-01 | 0.379 |
R-HSA-380287 | Centrosome maturation | 4.233809e-01 | 0.373 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 4.233809e-01 | 0.373 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.247442e-01 | 0.372 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.270585e-01 | 0.370 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 4.270585e-01 | 0.370 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 4.270585e-01 | 0.370 |
R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 4.270585e-01 | 0.370 |
R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 4.270585e-01 | 0.370 |
R-HSA-9637687 | Suppression of phagosomal maturation | 4.270585e-01 | 0.370 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 4.284373e-01 | 0.368 |
R-HSA-445095 | Interaction between L1 and Ankyrins | 4.369545e-01 | 0.360 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 4.369545e-01 | 0.360 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.369545e-01 | 0.360 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 4.369545e-01 | 0.360 |
R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.369545e-01 | 0.360 |
R-HSA-194138 | Signaling by VEGF | 4.397262e-01 | 0.357 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 4.410695e-01 | 0.355 |
R-HSA-4086400 | PCP/CE pathway | 4.410695e-01 | 0.355 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 4.466802e-01 | 0.350 |
R-HSA-5576892 | Phase 0 - rapid depolarisation | 4.466802e-01 | 0.350 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 4.466802e-01 | 0.350 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.466802e-01 | 0.350 |
R-HSA-622312 | Inflammasomes | 4.466802e-01 | 0.350 |
R-HSA-9659379 | Sensory processing of sound | 4.468995e-01 | 0.350 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 4.562385e-01 | 0.341 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 4.562385e-01 | 0.341 |
R-HSA-210745 | Regulation of gene expression in beta cells | 4.562385e-01 | 0.341 |
R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.562385e-01 | 0.341 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.562385e-01 | 0.341 |
R-HSA-180024 | DARPP-32 events | 4.562385e-01 | 0.341 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 4.584568e-01 | 0.339 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 4.656323e-01 | 0.332 |
R-HSA-2424491 | DAP12 signaling | 4.656323e-01 | 0.332 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.656323e-01 | 0.332 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.656323e-01 | 0.332 |
R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.656323e-01 | 0.332 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.656323e-01 | 0.332 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.656323e-01 | 0.332 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.656323e-01 | 0.332 |
R-HSA-157118 | Signaling by NOTCH | 4.726602e-01 | 0.325 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.748643e-01 | 0.323 |
R-HSA-2129379 | Molecules associated with elastic fibres | 4.748643e-01 | 0.323 |
R-HSA-399719 | Trafficking of AMPA receptors | 4.748643e-01 | 0.323 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.748643e-01 | 0.323 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.748643e-01 | 0.323 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.755278e-01 | 0.323 |
R-HSA-195721 | Signaling by WNT | 4.770159e-01 | 0.321 |
R-HSA-4791275 | Signaling by WNT in cancer | 4.839374e-01 | 0.315 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.839374e-01 | 0.315 |
R-HSA-69190 | DNA strand elongation | 4.839374e-01 | 0.315 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.839374e-01 | 0.315 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 4.839374e-01 | 0.315 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 4.867262e-01 | 0.313 |
R-HSA-354192 | Integrin signaling | 4.928543e-01 | 0.307 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 4.928543e-01 | 0.307 |
R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.928543e-01 | 0.307 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 4.928543e-01 | 0.307 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.928543e-01 | 0.307 |
R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.016177e-01 | 0.300 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 5.016177e-01 | 0.300 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.016177e-01 | 0.300 |
R-HSA-9645723 | Diseases of programmed cell death | 5.032424e-01 | 0.298 |
R-HSA-5696400 | Dual Incision in GG-NER | 5.102302e-01 | 0.292 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 5.102302e-01 | 0.292 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.102302e-01 | 0.292 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.102302e-01 | 0.292 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.102302e-01 | 0.292 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.102302e-01 | 0.292 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 5.102302e-01 | 0.292 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 5.102302e-01 | 0.292 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 5.102302e-01 | 0.292 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 5.140615e-01 | 0.289 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 5.186943e-01 | 0.285 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 5.186943e-01 | 0.285 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 5.186943e-01 | 0.285 |
R-HSA-169911 | Regulation of Apoptosis | 5.186943e-01 | 0.285 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 5.186943e-01 | 0.285 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.248367e-01 | 0.280 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 5.270127e-01 | 0.278 |
R-HSA-9682385 | FLT3 signaling in disease | 5.270127e-01 | 0.278 |
R-HSA-8941326 | RUNX2 regulates bone development | 5.270127e-01 | 0.278 |
R-HSA-111933 | Calmodulin induced events | 5.270127e-01 | 0.278 |
R-HSA-111997 | CaM pathway | 5.270127e-01 | 0.278 |
R-HSA-114604 | GPVI-mediated activation cascade | 5.270127e-01 | 0.278 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.270127e-01 | 0.278 |
R-HSA-74158 | RNA Polymerase III Transcription | 5.270127e-01 | 0.278 |
R-HSA-389948 | Co-inhibition by PD-1 | 5.292779e-01 | 0.276 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.292779e-01 | 0.276 |
R-HSA-4641258 | Degradation of DVL | 5.351879e-01 | 0.271 |
R-HSA-4641257 | Degradation of AXIN | 5.351879e-01 | 0.271 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.351879e-01 | 0.271 |
R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.351879e-01 | 0.271 |
R-HSA-5689896 | Ovarian tumor domain proteases | 5.351879e-01 | 0.271 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.399483e-01 | 0.268 |
R-HSA-376176 | Signaling by ROBO receptors | 5.399483e-01 | 0.268 |
R-HSA-1566948 | Elastic fibre formation | 5.432222e-01 | 0.265 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.432222e-01 | 0.265 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 5.432222e-01 | 0.265 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.432222e-01 | 0.265 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 5.432222e-01 | 0.265 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.511182e-01 | 0.259 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.511182e-01 | 0.259 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.511182e-01 | 0.259 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 5.511182e-01 | 0.259 |
R-HSA-69541 | Stabilization of p53 | 5.511182e-01 | 0.259 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.557581e-01 | 0.255 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.557581e-01 | 0.255 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.559104e-01 | 0.255 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 5.588781e-01 | 0.253 |
R-HSA-202433 | Generation of second messenger molecules | 5.588781e-01 | 0.253 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.588781e-01 | 0.253 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.588781e-01 | 0.253 |
R-HSA-5260271 | Diseases of Immune System | 5.588781e-01 | 0.253 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.588781e-01 | 0.253 |
R-HSA-451927 | Interleukin-2 family signaling | 5.588781e-01 | 0.253 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.607892e-01 | 0.251 |
R-HSA-8957275 | Post-translational protein phosphorylation | 5.657796e-01 | 0.247 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 5.665043e-01 | 0.247 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 5.665043e-01 | 0.247 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.665043e-01 | 0.247 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.665043e-01 | 0.247 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.665043e-01 | 0.247 |
R-HSA-9614085 | FOXO-mediated transcription | 5.707292e-01 | 0.244 |
R-HSA-69306 | DNA Replication | 5.719895e-01 | 0.243 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 5.719895e-01 | 0.243 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 5.739992e-01 | 0.241 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.739992e-01 | 0.241 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 5.739992e-01 | 0.241 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 5.739992e-01 | 0.241 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.739992e-01 | 0.241 |
R-HSA-9683701 | Translation of Structural Proteins | 5.739992e-01 | 0.241 |
R-HSA-111996 | Ca-dependent events | 5.813650e-01 | 0.236 |
R-HSA-1280218 | Adaptive Immune System | 5.870293e-01 | 0.231 |
R-HSA-5654743 | Signaling by FGFR4 | 5.886038e-01 | 0.230 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.886038e-01 | 0.230 |
R-HSA-8854214 | TBC/RABGAPs | 5.886038e-01 | 0.230 |
R-HSA-9637690 | Response of Mtb to phagocytosis | 5.886038e-01 | 0.230 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 5.948631e-01 | 0.226 |
R-HSA-111885 | Opioid Signalling | 5.948631e-01 | 0.226 |
R-HSA-877300 | Interferon gamma signaling | 5.952877e-01 | 0.225 |
R-HSA-2172127 | DAP12 interactions | 5.957179e-01 | 0.225 |
R-HSA-190828 | Gap junction trafficking | 5.957179e-01 | 0.225 |
R-HSA-373752 | Netrin-1 signaling | 5.957179e-01 | 0.225 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.957179e-01 | 0.225 |
R-HSA-3214858 | RMTs methylate histone arginines | 5.957179e-01 | 0.225 |
R-HSA-9907900 | Proteasome assembly | 5.957179e-01 | 0.225 |
R-HSA-9833110 | RSV-host interactions | 5.995667e-01 | 0.222 |
R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.027094e-01 | 0.220 |
R-HSA-774815 | Nucleosome assembly | 6.027094e-01 | 0.220 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.027094e-01 | 0.220 |
R-HSA-5654741 | Signaling by FGFR3 | 6.027094e-01 | 0.220 |
R-HSA-6783310 | Fanconi Anemia Pathway | 6.027094e-01 | 0.220 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.027094e-01 | 0.220 |
R-HSA-1489509 | DAG and IP3 signaling | 6.027094e-01 | 0.220 |
R-HSA-9824272 | Somitogenesis | 6.027094e-01 | 0.220 |
R-HSA-8951664 | Neddylation | 6.045071e-01 | 0.219 |
R-HSA-109581 | Apoptosis | 6.066246e-01 | 0.217 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.095805e-01 | 0.215 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.095805e-01 | 0.215 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.095805e-01 | 0.215 |
R-HSA-9675135 | Diseases of DNA repair | 6.095805e-01 | 0.215 |
R-HSA-75153 | Apoptotic execution phase | 6.095805e-01 | 0.215 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.163331e-01 | 0.210 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.163331e-01 | 0.210 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.163331e-01 | 0.210 |
R-HSA-437239 | Recycling pathway of L1 | 6.163331e-01 | 0.210 |
R-HSA-1236975 | Antigen processing-Cross presentation | 6.179710e-01 | 0.209 |
R-HSA-9694516 | SARS-CoV-2 Infection | 6.210952e-01 | 0.207 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.229693e-01 | 0.206 |
R-HSA-389356 | Co-stimulation by CD28 | 6.229693e-01 | 0.206 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 6.268680e-01 | 0.203 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 6.294912e-01 | 0.201 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 6.294912e-01 | 0.201 |
R-HSA-2871796 | FCERI mediated MAPK activation | 6.357204e-01 | 0.197 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 6.359006e-01 | 0.197 |
R-HSA-5658442 | Regulation of RAS by GAPs | 6.359006e-01 | 0.197 |
R-HSA-9864848 | Complex IV assembly | 6.421995e-01 | 0.192 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 6.421995e-01 | 0.192 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.443508e-01 | 0.191 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 6.443508e-01 | 0.191 |
R-HSA-72187 | mRNA 3'-end processing | 6.483899e-01 | 0.188 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.483899e-01 | 0.188 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 6.483899e-01 | 0.188 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.483899e-01 | 0.188 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.486053e-01 | 0.188 |
R-HSA-5689880 | Ub-specific processing proteases | 6.498363e-01 | 0.187 |
R-HSA-445355 | Smooth Muscle Contraction | 6.544735e-01 | 0.184 |
R-HSA-9639288 | Amino acids regulate mTORC1 | 6.544735e-01 | 0.184 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.544735e-01 | 0.184 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 6.544735e-01 | 0.184 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 6.565289e-01 | 0.183 |
R-HSA-72649 | Translation initiation complex formation | 6.604523e-01 | 0.180 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.604523e-01 | 0.180 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.663279e-01 | 0.176 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 6.721022e-01 | 0.173 |
R-HSA-5654736 | Signaling by FGFR1 | 6.721022e-01 | 0.173 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.721022e-01 | 0.173 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.721022e-01 | 0.173 |
R-HSA-5578775 | Ion homeostasis | 6.721022e-01 | 0.173 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.721022e-01 | 0.173 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.721022e-01 | 0.173 |
R-HSA-9679506 | SARS-CoV Infections | 6.730560e-01 | 0.172 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 6.777770e-01 | 0.169 |
R-HSA-3371556 | Cellular response to heat stress | 6.812002e-01 | 0.167 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.833539e-01 | 0.165 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.833539e-01 | 0.165 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.888346e-01 | 0.162 |
R-HSA-186712 | Regulation of beta-cell development | 6.888346e-01 | 0.162 |
R-HSA-1227986 | Signaling by ERBB2 | 6.942208e-01 | 0.159 |
R-HSA-351202 | Metabolism of polyamines | 6.942208e-01 | 0.159 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.995140e-01 | 0.155 |
R-HSA-112043 | PLC beta mediated events | 6.995140e-01 | 0.155 |
R-HSA-9793380 | Formation of paraxial mesoderm | 6.995140e-01 | 0.155 |
R-HSA-1442490 | Collagen degradation | 6.995140e-01 | 0.155 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 7.002942e-01 | 0.155 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 7.002942e-01 | 0.155 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 7.002942e-01 | 0.155 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 7.047160e-01 | 0.152 |
R-HSA-1268020 | Mitochondrial protein import | 7.047160e-01 | 0.152 |
R-HSA-5617833 | Cilium Assembly | 7.051067e-01 | 0.152 |
R-HSA-5688426 | Deubiquitination | 7.053307e-01 | 0.152 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.098282e-01 | 0.149 |
R-HSA-373755 | Semaphorin interactions | 7.098282e-01 | 0.149 |
R-HSA-936837 | Ion transport by P-type ATPases | 7.148523e-01 | 0.146 |
R-HSA-9609690 | HCMV Early Events | 7.229551e-01 | 0.141 |
R-HSA-5693606 | DNA Double Strand Break Response | 7.294102e-01 | 0.137 |
R-HSA-112040 | G-protein mediated events | 7.294102e-01 | 0.137 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 7.294102e-01 | 0.137 |
R-HSA-196807 | Nicotinate metabolism | 7.294102e-01 | 0.137 |
R-HSA-168256 | Immune System | 7.360801e-01 | 0.133 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 7.432274e-01 | 0.129 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.455320e-01 | 0.128 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 7.476751e-01 | 0.126 |
R-HSA-5632684 | Hedgehog 'on' state | 7.476751e-01 | 0.126 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.487579e-01 | 0.126 |
R-HSA-5357801 | Programmed Cell Death | 7.508216e-01 | 0.124 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.563415e-01 | 0.121 |
R-HSA-1226099 | Signaling by FGFR in disease | 7.605628e-01 | 0.119 |
R-HSA-9013694 | Signaling by NOTCH4 | 7.605628e-01 | 0.119 |
R-HSA-1222556 | ROS and RNS production in phagocytes | 7.605628e-01 | 0.119 |
R-HSA-597592 | Post-translational protein modification | 7.622038e-01 | 0.118 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.673853e-01 | 0.115 |
R-HSA-5689603 | UCH proteinases | 7.687880e-01 | 0.114 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.689639e-01 | 0.114 |
R-HSA-9694635 | Translation of Structural Proteins | 7.727944e-01 | 0.112 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 7.733231e-01 | 0.112 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.767317e-01 | 0.110 |
R-HSA-5619084 | ABC transporter disorders | 7.767317e-01 | 0.110 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.806009e-01 | 0.108 |
R-HSA-446203 | Asparagine N-linked glycosylation | 7.838511e-01 | 0.106 |
R-HSA-5654738 | Signaling by FGFR2 | 7.844033e-01 | 0.105 |
R-HSA-9833482 | PKR-mediated signaling | 7.844033e-01 | 0.105 |
R-HSA-9679191 | Potential therapeutics for SARS | 7.903509e-01 | 0.102 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.918123e-01 | 0.101 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.954211e-01 | 0.099 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.957719e-01 | 0.099 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.989676e-01 | 0.097 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 8.058778e-01 | 0.094 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.087868e-01 | 0.092 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.092436e-01 | 0.092 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 8.112997e-01 | 0.091 |
R-HSA-9006936 | Signaling by TGFB family members | 8.162375e-01 | 0.088 |
R-HSA-1236974 | ER-Phagosome pathway | 8.189961e-01 | 0.087 |
R-HSA-112310 | Neurotransmitter release cycle | 8.221352e-01 | 0.085 |
R-HSA-73884 | Base Excision Repair | 8.221352e-01 | 0.085 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.252201e-01 | 0.083 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 8.282517e-01 | 0.082 |
R-HSA-109582 | Hemostasis | 8.309126e-01 | 0.080 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.312309e-01 | 0.080 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 8.426414e-01 | 0.074 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.435112e-01 | 0.074 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.453718e-01 | 0.073 |
R-HSA-112315 | Transmission across Chemical Synapses | 8.484513e-01 | 0.071 |
R-HSA-9609646 | HCMV Infection | 8.494616e-01 | 0.071 |
R-HSA-190236 | Signaling by FGFR | 8.506918e-01 | 0.070 |
R-HSA-5610787 | Hedgehog 'off' state | 8.558294e-01 | 0.068 |
R-HSA-70171 | Glycolysis | 8.558294e-01 | 0.068 |
R-HSA-382556 | ABC-family proteins mediated transport | 8.558294e-01 | 0.068 |
R-HSA-611105 | Respiratory electron transport | 8.576778e-01 | 0.067 |
R-HSA-5696398 | Nucleotide Excision Repair | 8.702091e-01 | 0.060 |
R-HSA-418346 | Platelet homeostasis | 8.724627e-01 | 0.059 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.768536e-01 | 0.057 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.768536e-01 | 0.057 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.825605e-01 | 0.054 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.851886e-01 | 0.053 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.851886e-01 | 0.053 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.871830e-01 | 0.052 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.948212e-01 | 0.048 |
R-HSA-9658195 | Leishmania infection | 8.959238e-01 | 0.048 |
R-HSA-9824443 | Parasitic Infection Pathways | 8.959238e-01 | 0.048 |
R-HSA-72737 | Cap-dependent Translation Initiation | 8.966488e-01 | 0.047 |
R-HSA-72613 | Eukaryotic Translation Initiation | 8.966488e-01 | 0.047 |
R-HSA-70326 | Glucose metabolism | 8.984447e-01 | 0.047 |
R-HSA-9824446 | Viral Infection Pathways | 9.021176e-01 | 0.045 |
R-HSA-73886 | Chromosome Maintenance | 9.053230e-01 | 0.043 |
R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 9.053230e-01 | 0.043 |
R-HSA-162909 | Host Interactions of HIV factors | 9.101752e-01 | 0.041 |
R-HSA-1483257 | Phospholipid metabolism | 9.123447e-01 | 0.040 |
R-HSA-397014 | Muscle contraction | 9.124465e-01 | 0.040 |
R-HSA-6798695 | Neutrophil degranulation | 9.200040e-01 | 0.036 |
R-HSA-5576891 | Cardiac conduction | 9.232946e-01 | 0.035 |
R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 9.232946e-01 | 0.035 |
R-HSA-1474228 | Degradation of the extracellular matrix | 9.246290e-01 | 0.034 |
R-HSA-163685 | Integration of energy metabolism | 9.309616e-01 | 0.031 |
R-HSA-9948299 | Ribosome-associated quality control | 9.333436e-01 | 0.030 |
R-HSA-5358351 | Signaling by Hedgehog | 9.333436e-01 | 0.030 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 9.345038e-01 | 0.029 |
R-HSA-5619115 | Disorders of transmembrane transporters | 9.469971e-01 | 0.024 |
R-HSA-9609507 | Protein localization | 9.496753e-01 | 0.022 |
R-HSA-1989781 | PPARA activates gene expression | 9.514135e-01 | 0.022 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.514135e-01 | 0.022 |
R-HSA-9610379 | HCMV Late Events | 9.530920e-01 | 0.021 |
R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 9.530920e-01 | 0.021 |
R-HSA-9711097 | Cellular response to starvation | 9.539094e-01 | 0.020 |
R-HSA-416476 | G alpha (q) signalling events | 9.586651e-01 | 0.018 |
R-HSA-5619102 | SLC transporter disorders | 9.606560e-01 | 0.017 |
R-HSA-73894 | DNA Repair | 9.618506e-01 | 0.017 |
R-HSA-1643685 | Disease | 9.624804e-01 | 0.017 |
R-HSA-168249 | Innate Immune System | 9.633768e-01 | 0.016 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 9.643366e-01 | 0.016 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.668850e-01 | 0.015 |
R-HSA-388396 | GPCR downstream signalling | 9.683451e-01 | 0.014 |
R-HSA-168255 | Influenza Infection | 9.687013e-01 | 0.014 |
R-HSA-112316 | Neuronal System | 9.716742e-01 | 0.012 |
R-HSA-983712 | Ion channel transport | 9.737550e-01 | 0.012 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 9.759680e-01 | 0.011 |
R-HSA-418594 | G alpha (i) signalling events | 9.799869e-01 | 0.009 |
R-HSA-72172 | mRNA Splicing | 9.802039e-01 | 0.009 |
R-HSA-1474244 | Extracellular matrix organization | 9.848718e-01 | 0.007 |
R-HSA-372790 | Signaling by GPCR | 9.865518e-01 | 0.006 |
R-HSA-162906 | HIV Infection | 9.868078e-01 | 0.006 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.870181e-01 | 0.006 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.874886e-01 | 0.005 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 9.889439e-01 | 0.005 |
R-HSA-5663205 | Infectious disease | 9.893760e-01 | 0.005 |
R-HSA-9824439 | Bacterial Infection Pathways | 9.940178e-01 | 0.003 |
R-HSA-72766 | Translation | 9.967637e-01 | 0.001 |
R-HSA-392499 | Metabolism of proteins | 9.972095e-01 | 0.001 |
R-HSA-8953854 | Metabolism of RNA | 9.974960e-01 | 0.001 |
R-HSA-8957322 | Metabolism of steroids | 9.976334e-01 | 0.001 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.988384e-01 | 0.001 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.993316e-01 | 0.000 |
R-HSA-425407 | SLC-mediated transmembrane transport | 9.993665e-01 | 0.000 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.997755e-01 | 0.000 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 9.998502e-01 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 9.999799e-01 | 0.000 |
R-HSA-382551 | Transport of small molecules | 9.999808e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 1.000000e+00 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000e+00 | -0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.875 | 0.361 | 1 | 0.853 |
COT |
0.873 | 0.205 | 2 | 0.849 |
PIM3 |
0.870 | 0.330 | -3 | 0.894 |
NDR2 |
0.869 | 0.267 | -3 | 0.878 |
HIPK4 |
0.867 | 0.347 | 1 | 0.822 |
RSK2 |
0.866 | 0.337 | -3 | 0.861 |
CDC7 |
0.865 | 0.156 | 1 | 0.863 |
SRPK1 |
0.864 | 0.314 | -3 | 0.851 |
PRKD1 |
0.863 | 0.288 | -3 | 0.867 |
SKMLCK |
0.862 | 0.329 | -2 | 0.909 |
MOS |
0.861 | 0.219 | 1 | 0.884 |
P90RSK |
0.860 | 0.306 | -3 | 0.864 |
PIM1 |
0.859 | 0.320 | -3 | 0.869 |
CDKL1 |
0.857 | 0.278 | -3 | 0.875 |
PRKD2 |
0.857 | 0.279 | -3 | 0.844 |
RSK3 |
0.857 | 0.287 | -3 | 0.851 |
MAPKAPK2 |
0.857 | 0.288 | -3 | 0.830 |
AURC |
0.856 | 0.280 | -2 | 0.726 |
IKKB |
0.856 | 0.038 | -2 | 0.761 |
NDR1 |
0.856 | 0.200 | -3 | 0.878 |
CLK2 |
0.856 | 0.376 | -3 | 0.849 |
LATS2 |
0.856 | 0.186 | -5 | 0.723 |
CAMK1B |
0.856 | 0.227 | -3 | 0.889 |
CDKL5 |
0.856 | 0.268 | -3 | 0.873 |
MTOR |
0.855 | 0.043 | 1 | 0.848 |
GRK1 |
0.855 | 0.220 | -2 | 0.805 |
SRPK2 |
0.855 | 0.296 | -3 | 0.798 |
RSK4 |
0.855 | 0.336 | -3 | 0.846 |
NLK |
0.854 | 0.158 | 1 | 0.885 |
ICK |
0.854 | 0.301 | -3 | 0.893 |
DYRK2 |
0.852 | 0.277 | 1 | 0.772 |
CLK4 |
0.852 | 0.327 | -3 | 0.855 |
KIS |
0.851 | 0.154 | 1 | 0.765 |
PKACB |
0.851 | 0.313 | -2 | 0.736 |
RAF1 |
0.851 | 0.024 | 1 | 0.866 |
PRPK |
0.851 | -0.060 | -1 | 0.834 |
PKACG |
0.850 | 0.223 | -2 | 0.787 |
P70S6KB |
0.850 | 0.248 | -3 | 0.862 |
HIPK2 |
0.850 | 0.312 | 1 | 0.694 |
PKN3 |
0.850 | 0.170 | -3 | 0.869 |
CAMLCK |
0.850 | 0.242 | -2 | 0.895 |
DAPK2 |
0.850 | 0.275 | -3 | 0.886 |
ERK5 |
0.849 | 0.107 | 1 | 0.854 |
MSK1 |
0.849 | 0.305 | -3 | 0.842 |
NUAK2 |
0.849 | 0.166 | -3 | 0.891 |
MAPKAPK3 |
0.849 | 0.216 | -3 | 0.845 |
TBK1 |
0.849 | -0.037 | 1 | 0.777 |
CAMK2D |
0.848 | 0.168 | -3 | 0.861 |
PRKX |
0.848 | 0.320 | -3 | 0.794 |
CAMK2A |
0.848 | 0.243 | 2 | 0.809 |
ATR |
0.847 | 0.050 | 1 | 0.839 |
CAMK2G |
0.847 | 0.003 | 2 | 0.816 |
MSK2 |
0.847 | 0.255 | -3 | 0.841 |
CAMK2B |
0.847 | 0.203 | 2 | 0.789 |
IKKA |
0.846 | 0.062 | -2 | 0.754 |
CLK1 |
0.846 | 0.306 | -3 | 0.831 |
GCN2 |
0.846 | -0.120 | 2 | 0.786 |
LATS1 |
0.846 | 0.257 | -3 | 0.886 |
MST4 |
0.846 | 0.092 | 2 | 0.847 |
HIPK1 |
0.845 | 0.312 | 1 | 0.786 |
AMPKA1 |
0.845 | 0.164 | -3 | 0.881 |
IKKE |
0.845 | -0.058 | 1 | 0.768 |
SRPK3 |
0.845 | 0.230 | -3 | 0.825 |
PAK1 |
0.845 | 0.205 | -2 | 0.841 |
DSTYK |
0.845 | -0.046 | 2 | 0.864 |
TGFBR2 |
0.844 | 0.044 | -2 | 0.834 |
BMPR2 |
0.844 | -0.085 | -2 | 0.898 |
NIK |
0.844 | 0.127 | -3 | 0.875 |
PDHK4 |
0.844 | -0.226 | 1 | 0.880 |
PKN2 |
0.844 | 0.133 | -3 | 0.866 |
PKCD |
0.843 | 0.158 | 2 | 0.764 |
WNK1 |
0.843 | 0.068 | -2 | 0.903 |
GRK5 |
0.843 | -0.021 | -3 | 0.815 |
GRK7 |
0.842 | 0.186 | 1 | 0.801 |
NEK6 |
0.842 | -0.001 | -2 | 0.882 |
AKT2 |
0.842 | 0.303 | -3 | 0.804 |
BMPR1B |
0.842 | 0.182 | 1 | 0.823 |
GRK6 |
0.841 | 0.070 | 1 | 0.852 |
AMPKA2 |
0.841 | 0.180 | -3 | 0.869 |
MARK4 |
0.841 | 0.058 | 4 | 0.842 |
ULK2 |
0.841 | -0.134 | 2 | 0.764 |
RIPK3 |
0.841 | -0.023 | 3 | 0.706 |
CHAK2 |
0.840 | 0.018 | -1 | 0.852 |
PDHK1 |
0.840 | -0.166 | 1 | 0.857 |
DYRK4 |
0.840 | 0.261 | 1 | 0.709 |
AURB |
0.839 | 0.214 | -2 | 0.725 |
SGK3 |
0.839 | 0.269 | -3 | 0.840 |
PRKD3 |
0.839 | 0.217 | -3 | 0.826 |
DYRK1A |
0.839 | 0.282 | 1 | 0.802 |
MNK2 |
0.838 | 0.169 | -2 | 0.843 |
TSSK1 |
0.838 | 0.140 | -3 | 0.890 |
BCKDK |
0.838 | -0.064 | -1 | 0.833 |
JNK2 |
0.838 | 0.199 | 1 | 0.711 |
PAK3 |
0.838 | 0.148 | -2 | 0.832 |
HUNK |
0.838 | -0.047 | 2 | 0.783 |
CDK7 |
0.838 | 0.139 | 1 | 0.756 |
TGFBR1 |
0.838 | 0.134 | -2 | 0.837 |
PKG2 |
0.837 | 0.221 | -2 | 0.727 |
PIM2 |
0.837 | 0.273 | -3 | 0.837 |
CDK8 |
0.836 | 0.102 | 1 | 0.746 |
MYLK4 |
0.836 | 0.218 | -2 | 0.827 |
NEK7 |
0.835 | -0.134 | -3 | 0.808 |
AURA |
0.835 | 0.196 | -2 | 0.710 |
FAM20C |
0.835 | 0.065 | 2 | 0.609 |
MASTL |
0.835 | -0.115 | -2 | 0.823 |
ALK4 |
0.835 | 0.087 | -2 | 0.862 |
JNK3 |
0.834 | 0.169 | 1 | 0.738 |
TSSK2 |
0.834 | 0.072 | -5 | 0.788 |
PKACA |
0.834 | 0.273 | -2 | 0.685 |
PAK6 |
0.834 | 0.169 | -2 | 0.762 |
CAMK4 |
0.834 | 0.081 | -3 | 0.855 |
CDK1 |
0.834 | 0.148 | 1 | 0.716 |
MLK1 |
0.833 | -0.117 | 2 | 0.787 |
MAK |
0.833 | 0.362 | -2 | 0.799 |
CDK19 |
0.833 | 0.113 | 1 | 0.713 |
MNK1 |
0.833 | 0.155 | -2 | 0.847 |
HIPK3 |
0.833 | 0.256 | 1 | 0.791 |
DYRK3 |
0.833 | 0.295 | 1 | 0.785 |
DLK |
0.833 | -0.039 | 1 | 0.850 |
QSK |
0.833 | 0.123 | 4 | 0.818 |
DYRK1B |
0.832 | 0.240 | 1 | 0.739 |
GRK4 |
0.832 | -0.079 | -2 | 0.848 |
CDK18 |
0.832 | 0.150 | 1 | 0.691 |
PKCB |
0.831 | 0.108 | 2 | 0.710 |
MELK |
0.831 | 0.129 | -3 | 0.852 |
ATM |
0.831 | 0.005 | 1 | 0.781 |
PAK2 |
0.831 | 0.130 | -2 | 0.826 |
BRSK1 |
0.831 | 0.130 | -3 | 0.850 |
NIM1 |
0.831 | -0.011 | 3 | 0.736 |
NUAK1 |
0.831 | 0.104 | -3 | 0.853 |
P38A |
0.830 | 0.151 | 1 | 0.783 |
WNK3 |
0.830 | -0.160 | 1 | 0.825 |
RIPK1 |
0.830 | -0.068 | 1 | 0.820 |
DCAMKL1 |
0.830 | 0.197 | -3 | 0.850 |
PKCA |
0.830 | 0.113 | 2 | 0.702 |
ANKRD3 |
0.830 | -0.081 | 1 | 0.867 |
MLK2 |
0.830 | -0.046 | 2 | 0.796 |
PLK1 |
0.830 | 0.001 | -2 | 0.825 |
P38B |
0.830 | 0.165 | 1 | 0.718 |
ULK1 |
0.829 | -0.189 | -3 | 0.767 |
PKCG |
0.829 | 0.080 | 2 | 0.713 |
PHKG1 |
0.829 | 0.072 | -3 | 0.865 |
CDK5 |
0.829 | 0.130 | 1 | 0.769 |
NEK9 |
0.828 | -0.130 | 2 | 0.812 |
MLK3 |
0.828 | -0.018 | 2 | 0.718 |
AKT1 |
0.828 | 0.270 | -3 | 0.814 |
P38G |
0.828 | 0.151 | 1 | 0.639 |
ALK2 |
0.827 | 0.090 | -2 | 0.844 |
CDK13 |
0.827 | 0.091 | 1 | 0.732 |
SIK |
0.827 | 0.121 | -3 | 0.828 |
DNAPK |
0.827 | 0.055 | 1 | 0.740 |
TTBK2 |
0.826 | -0.141 | 2 | 0.687 |
PASK |
0.826 | 0.220 | -3 | 0.896 |
ACVR2B |
0.826 | 0.068 | -2 | 0.829 |
ERK1 |
0.826 | 0.131 | 1 | 0.714 |
PKR |
0.826 | 0.029 | 1 | 0.832 |
PKCZ |
0.825 | 0.064 | 2 | 0.755 |
ACVR2A |
0.825 | 0.047 | -2 | 0.817 |
CDK3 |
0.825 | 0.155 | 1 | 0.661 |
TLK2 |
0.824 | 0.006 | 1 | 0.798 |
SGK1 |
0.824 | 0.309 | -3 | 0.751 |
AKT3 |
0.824 | 0.302 | -3 | 0.764 |
P70S6K |
0.824 | 0.212 | -3 | 0.805 |
IRE1 |
0.824 | -0.089 | 1 | 0.783 |
BRSK2 |
0.824 | 0.049 | -3 | 0.848 |
MARK3 |
0.824 | 0.071 | 4 | 0.779 |
CHK1 |
0.823 | 0.059 | -3 | 0.855 |
VRK2 |
0.823 | -0.043 | 1 | 0.885 |
CDK12 |
0.823 | 0.108 | 1 | 0.708 |
MAPKAPK5 |
0.823 | 0.090 | -3 | 0.810 |
YSK4 |
0.823 | -0.074 | 1 | 0.810 |
CDK17 |
0.823 | 0.119 | 1 | 0.643 |
PLK3 |
0.822 | -0.028 | 2 | 0.766 |
MEK1 |
0.822 | -0.115 | 2 | 0.833 |
DAPK3 |
0.822 | 0.263 | -3 | 0.866 |
PKCH |
0.822 | 0.055 | 2 | 0.694 |
QIK |
0.822 | -0.025 | -3 | 0.852 |
CAMK1G |
0.822 | 0.139 | -3 | 0.836 |
CDK14 |
0.822 | 0.157 | 1 | 0.735 |
BMPR1A |
0.821 | 0.114 | 1 | 0.799 |
SMG1 |
0.821 | -0.034 | 1 | 0.790 |
DRAK1 |
0.821 | 0.033 | 1 | 0.808 |
CDK10 |
0.820 | 0.178 | 1 | 0.721 |
CAMK1D |
0.820 | 0.218 | -3 | 0.787 |
SMMLCK |
0.820 | 0.180 | -3 | 0.865 |
CDK9 |
0.819 | 0.080 | 1 | 0.740 |
MARK2 |
0.819 | 0.031 | 4 | 0.751 |
NEK2 |
0.819 | -0.075 | 2 | 0.795 |
ERK2 |
0.819 | 0.078 | 1 | 0.750 |
P38D |
0.819 | 0.152 | 1 | 0.656 |
MPSK1 |
0.818 | 0.151 | 1 | 0.808 |
GRK2 |
0.818 | -0.012 | -2 | 0.749 |
DAPK1 |
0.817 | 0.251 | -3 | 0.857 |
CK1E |
0.817 | 0.020 | -3 | 0.566 |
MLK4 |
0.817 | -0.091 | 2 | 0.692 |
MOK |
0.817 | 0.298 | 1 | 0.789 |
IRE2 |
0.816 | -0.100 | 2 | 0.728 |
DCAMKL2 |
0.816 | 0.087 | -3 | 0.860 |
PAK5 |
0.815 | 0.144 | -2 | 0.708 |
GSK3A |
0.815 | 0.091 | 4 | 0.472 |
PAK4 |
0.815 | 0.156 | -2 | 0.720 |
PRP4 |
0.815 | 0.041 | -3 | 0.712 |
CDK2 |
0.815 | 0.030 | 1 | 0.787 |
MST3 |
0.814 | 0.038 | 2 | 0.822 |
BRAF |
0.814 | -0.042 | -4 | 0.789 |
PLK4 |
0.814 | -0.088 | 2 | 0.619 |
MARK1 |
0.814 | 0.014 | 4 | 0.795 |
PKCT |
0.814 | 0.090 | 2 | 0.703 |
CHAK1 |
0.813 | -0.139 | 2 | 0.760 |
SNRK |
0.813 | -0.083 | 2 | 0.669 |
SSTK |
0.813 | 0.056 | 4 | 0.794 |
JNK1 |
0.812 | 0.125 | 1 | 0.695 |
CDK16 |
0.812 | 0.113 | 1 | 0.659 |
ROCK2 |
0.812 | 0.265 | -3 | 0.855 |
WNK4 |
0.811 | -0.041 | -2 | 0.893 |
GSK3B |
0.811 | 0.036 | 4 | 0.464 |
NEK5 |
0.811 | -0.045 | 1 | 0.838 |
TAO3 |
0.811 | -0.002 | 1 | 0.829 |
SBK |
0.811 | 0.268 | -3 | 0.715 |
MEKK1 |
0.811 | -0.125 | 1 | 0.825 |
PERK |
0.811 | -0.114 | -2 | 0.852 |
MEKK3 |
0.811 | -0.142 | 1 | 0.837 |
CK2A2 |
0.811 | 0.134 | 1 | 0.734 |
MRCKB |
0.810 | 0.240 | -3 | 0.818 |
MEK5 |
0.810 | -0.195 | 2 | 0.807 |
GAK |
0.809 | 0.107 | 1 | 0.875 |
MRCKA |
0.809 | 0.221 | -3 | 0.830 |
TLK1 |
0.809 | -0.096 | -2 | 0.857 |
CHK2 |
0.809 | 0.212 | -3 | 0.758 |
CK1D |
0.808 | 0.018 | -3 | 0.515 |
MEKK2 |
0.808 | -0.113 | 2 | 0.782 |
ZAK |
0.808 | -0.144 | 1 | 0.796 |
PKCE |
0.808 | 0.126 | 2 | 0.698 |
GRK3 |
0.807 | -0.006 | -2 | 0.712 |
PHKG2 |
0.807 | 0.015 | -3 | 0.835 |
IRAK4 |
0.807 | -0.082 | 1 | 0.789 |
CAMK1A |
0.807 | 0.214 | -3 | 0.765 |
PKCI |
0.807 | 0.050 | 2 | 0.725 |
LKB1 |
0.807 | 0.044 | -3 | 0.791 |
PDK1 |
0.806 | 0.056 | 1 | 0.816 |
PKN1 |
0.806 | 0.144 | -3 | 0.814 |
GCK |
0.806 | 0.064 | 1 | 0.837 |
HRI |
0.806 | -0.205 | -2 | 0.868 |
CK1A2 |
0.805 | 0.008 | -3 | 0.521 |
DMPK1 |
0.805 | 0.272 | -3 | 0.836 |
CK1G1 |
0.804 | -0.038 | -3 | 0.552 |
CRIK |
0.804 | 0.278 | -3 | 0.818 |
ERK7 |
0.803 | 0.029 | 2 | 0.523 |
NEK11 |
0.801 | -0.139 | 1 | 0.823 |
PINK1 |
0.800 | -0.194 | 1 | 0.837 |
NEK8 |
0.800 | -0.122 | 2 | 0.794 |
CK2A1 |
0.800 | 0.112 | 1 | 0.714 |
CAMKK2 |
0.800 | -0.079 | -2 | 0.759 |
BUB1 |
0.799 | 0.134 | -5 | 0.748 |
TNIK |
0.799 | 0.031 | 3 | 0.812 |
HPK1 |
0.799 | 0.035 | 1 | 0.824 |
TAO2 |
0.799 | -0.098 | 2 | 0.824 |
CDK4 |
0.799 | 0.106 | 1 | 0.692 |
PLK2 |
0.799 | -0.009 | -3 | 0.750 |
CDK6 |
0.798 | 0.082 | 1 | 0.717 |
PBK |
0.798 | 0.121 | 1 | 0.809 |
CAMKK1 |
0.798 | -0.155 | -2 | 0.758 |
TAK1 |
0.797 | -0.025 | 1 | 0.833 |
MAP3K15 |
0.797 | -0.056 | 1 | 0.793 |
MINK |
0.796 | -0.039 | 1 | 0.815 |
KHS1 |
0.796 | 0.064 | 1 | 0.809 |
PDHK3_TYR |
0.796 | 0.330 | 4 | 0.891 |
MST2 |
0.796 | -0.097 | 1 | 0.842 |
PKG1 |
0.796 | 0.163 | -2 | 0.645 |
MEKK6 |
0.795 | -0.082 | 1 | 0.816 |
TTBK1 |
0.795 | -0.203 | 2 | 0.608 |
ROCK1 |
0.795 | 0.222 | -3 | 0.828 |
HGK |
0.795 | -0.055 | 3 | 0.803 |
NEK4 |
0.795 | -0.110 | 1 | 0.807 |
KHS2 |
0.794 | 0.063 | 1 | 0.821 |
LRRK2 |
0.794 | -0.082 | 2 | 0.829 |
LOK |
0.794 | -0.015 | -2 | 0.781 |
EEF2K |
0.793 | -0.078 | 3 | 0.783 |
NEK1 |
0.792 | -0.054 | 1 | 0.809 |
IRAK1 |
0.792 | -0.267 | -1 | 0.766 |
VRK1 |
0.791 | -0.087 | 2 | 0.820 |
SLK |
0.790 | -0.052 | -2 | 0.726 |
MST1 |
0.786 | -0.121 | 1 | 0.817 |
PDHK4_TYR |
0.786 | 0.148 | 2 | 0.874 |
MAP2K4_TYR |
0.784 | 0.112 | -1 | 0.852 |
YSK1 |
0.784 | -0.085 | 2 | 0.788 |
TESK1_TYR |
0.784 | 0.075 | 3 | 0.847 |
STK33 |
0.783 | -0.149 | 2 | 0.603 |
MAP2K6_TYR |
0.783 | 0.093 | -1 | 0.862 |
MEK2 |
0.782 | -0.231 | 2 | 0.800 |
HASPIN |
0.781 | 0.043 | -1 | 0.733 |
TTK |
0.781 | -0.024 | -2 | 0.850 |
OSR1 |
0.780 | -0.055 | 2 | 0.786 |
LIMK2_TYR |
0.780 | 0.112 | -3 | 0.858 |
YANK3 |
0.780 | -0.034 | 2 | 0.401 |
PKMYT1_TYR |
0.779 | -0.002 | 3 | 0.819 |
RIPK2 |
0.779 | -0.258 | 1 | 0.772 |
PDHK1_TYR |
0.778 | 0.016 | -1 | 0.868 |
MAP2K7_TYR |
0.778 | -0.091 | 2 | 0.846 |
BMPR2_TYR |
0.778 | 0.034 | -1 | 0.855 |
BIKE |
0.777 | 0.069 | 1 | 0.772 |
EPHA6 |
0.776 | 0.075 | -1 | 0.853 |
NEK3 |
0.776 | -0.149 | 1 | 0.782 |
ASK1 |
0.774 | -0.105 | 1 | 0.781 |
CK1A |
0.773 | -0.014 | -3 | 0.429 |
PINK1_TYR |
0.772 | -0.138 | 1 | 0.858 |
EPHB4 |
0.772 | 0.041 | -1 | 0.828 |
RET |
0.772 | -0.047 | 1 | 0.819 |
MYO3B |
0.770 | -0.066 | 2 | 0.809 |
TAO1 |
0.768 | -0.107 | 1 | 0.762 |
TXK |
0.767 | 0.083 | 1 | 0.857 |
TNK2 |
0.766 | 0.028 | 3 | 0.718 |
MST1R |
0.766 | -0.110 | 3 | 0.765 |
DDR1 |
0.766 | -0.088 | 4 | 0.800 |
ABL2 |
0.766 | -0.012 | -1 | 0.783 |
LIMK1_TYR |
0.765 | -0.156 | 2 | 0.834 |
FGR |
0.765 | -0.033 | 1 | 0.869 |
TYRO3 |
0.765 | -0.114 | 3 | 0.743 |
AAK1 |
0.765 | 0.117 | 1 | 0.676 |
ROS1 |
0.765 | -0.091 | 3 | 0.712 |
ALPHAK3 |
0.764 | -0.119 | -1 | 0.741 |
CSF1R |
0.763 | -0.093 | 3 | 0.735 |
MYO3A |
0.763 | -0.135 | 1 | 0.792 |
YES1 |
0.763 | -0.050 | -1 | 0.818 |
TYK2 |
0.762 | -0.202 | 1 | 0.815 |
EPHA4 |
0.761 | -0.027 | 2 | 0.768 |
INSRR |
0.761 | -0.078 | 3 | 0.696 |
SRMS |
0.761 | -0.034 | 1 | 0.862 |
ABL1 |
0.761 | -0.046 | -1 | 0.775 |
JAK3 |
0.761 | -0.101 | 1 | 0.811 |
LCK |
0.761 | 0.020 | -1 | 0.812 |
JAK2 |
0.760 | -0.174 | 1 | 0.811 |
BLK |
0.759 | 0.037 | -1 | 0.809 |
FER |
0.759 | -0.137 | 1 | 0.874 |
HCK |
0.759 | -0.065 | -1 | 0.807 |
TNK1 |
0.759 | -0.014 | 3 | 0.728 |
EPHB1 |
0.758 | -0.068 | 1 | 0.862 |
FGFR2 |
0.758 | -0.119 | 3 | 0.756 |
NEK10_TYR |
0.758 | -0.049 | 1 | 0.715 |
EPHB3 |
0.757 | -0.051 | -1 | 0.818 |
EPHB2 |
0.757 | -0.039 | -1 | 0.806 |
ITK |
0.757 | -0.061 | -1 | 0.785 |
MERTK |
0.757 | -0.058 | 3 | 0.730 |
STLK3 |
0.756 | -0.199 | 1 | 0.774 |
KDR |
0.756 | -0.095 | 3 | 0.705 |
DDR2 |
0.754 | 0.053 | 3 | 0.691 |
FYN |
0.754 | 0.029 | -1 | 0.789 |
JAK1 |
0.754 | -0.061 | 1 | 0.779 |
AXL |
0.754 | -0.105 | 3 | 0.728 |
PDGFRB |
0.753 | -0.178 | 3 | 0.747 |
KIT |
0.752 | -0.157 | 3 | 0.738 |
TNNI3K_TYR |
0.752 | -0.061 | 1 | 0.807 |
EPHA7 |
0.751 | -0.049 | 2 | 0.761 |
MET |
0.751 | -0.111 | 3 | 0.737 |
BMX |
0.750 | -0.061 | -1 | 0.693 |
FGFR1 |
0.750 | -0.176 | 3 | 0.722 |
FGFR3 |
0.748 | -0.133 | 3 | 0.728 |
TEK |
0.748 | -0.188 | 3 | 0.679 |
FLT1 |
0.747 | -0.117 | -1 | 0.826 |
FLT3 |
0.747 | -0.222 | 3 | 0.732 |
EPHA1 |
0.747 | -0.096 | 3 | 0.711 |
EPHA3 |
0.747 | -0.119 | 2 | 0.737 |
LTK |
0.746 | -0.140 | 3 | 0.698 |
ALK |
0.746 | -0.151 | 3 | 0.666 |
TEC |
0.746 | -0.129 | -1 | 0.710 |
NTRK1 |
0.746 | -0.198 | -1 | 0.813 |
PTK2B |
0.745 | -0.058 | -1 | 0.748 |
WEE1_TYR |
0.745 | -0.140 | -1 | 0.742 |
BTK |
0.745 | -0.219 | -1 | 0.759 |
PTK6 |
0.744 | -0.199 | -1 | 0.718 |
EPHA5 |
0.744 | -0.064 | 2 | 0.748 |
CK1G3 |
0.744 | -0.061 | -3 | 0.384 |
PDGFRA |
0.743 | -0.260 | 3 | 0.746 |
INSR |
0.742 | -0.169 | 3 | 0.677 |
PTK2 |
0.742 | 0.031 | -1 | 0.790 |
NTRK3 |
0.740 | -0.152 | -1 | 0.766 |
LYN |
0.740 | -0.127 | 3 | 0.670 |
ERBB2 |
0.740 | -0.207 | 1 | 0.780 |
FRK |
0.740 | -0.148 | -1 | 0.814 |
EPHA8 |
0.739 | -0.087 | -1 | 0.799 |
SRC |
0.739 | -0.085 | -1 | 0.778 |
FLT4 |
0.738 | -0.223 | 3 | 0.709 |
NTRK2 |
0.738 | -0.250 | 3 | 0.703 |
YANK2 |
0.738 | -0.097 | 2 | 0.413 |
EGFR |
0.737 | -0.107 | 1 | 0.691 |
SYK |
0.737 | -0.003 | -1 | 0.766 |
MATK |
0.736 | -0.161 | -1 | 0.710 |
FGFR4 |
0.734 | -0.134 | -1 | 0.743 |
CSK |
0.734 | -0.177 | 2 | 0.763 |
EPHA2 |
0.731 | -0.082 | -1 | 0.768 |
IGF1R |
0.727 | -0.167 | 3 | 0.620 |
CK1G2 |
0.727 | -0.062 | -3 | 0.472 |
ERBB4 |
0.725 | -0.084 | 1 | 0.709 |
MUSK |
0.721 | -0.201 | 1 | 0.692 |
ZAP70 |
0.716 | -0.049 | -1 | 0.680 |
FES |
0.712 | -0.187 | -1 | 0.673 |