Motif 192 (n=183)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S330 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A0C4DFX4 | None | S2843 | ochoa | Snf2 related CREBBP activator protein | None |
| A8MV72 | None | S205 | ochoa | Putative UPF0607 protein ENSP00000382826 | None |
| H0Y626 | None | S29 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O00330 | PDHX | S168 | ochoa | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
| O00750 | PIK3C2B | S177 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) | Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:11533253, PubMed:9830063). Does not phosphorylate PtdIns(4,5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253, ECO:0000269|PubMed:9830063}. |
| O14686 | KMT2D | S477 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14813 | PHOX2A | S202 | psp | Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A) | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. |
| O14828 | SCAMP3 | S76 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15034 | RIMBP2 | S651 | ochoa | RIMS-binding protein 2 (RIM-BP2) | Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}. |
| O15357 | INPPL1 | S1167 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43184 | ADAM12 | S830 | ochoa | Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). {ECO:0000250}. |
| O43189 | PHF1 | S522 | ochoa | PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}. |
| O43295 | SRGAP3 | S895 | ochoa | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| O43426 | SYNJ1 | S1292 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O60293 | ZFC3H1 | S662 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60356 | NUPR1 | S23 | ochoa | Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) | Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}. |
| O60503 | ADCY9 | S688 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60941 | DTNB | S552 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75044 | SRGAP2 | S1013 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75815 | BCAR3 | S425 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75864 | PPP1R37 | S601 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O94989 | ARHGEF15 | S42 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
| O95361 | TRIM16 | S29 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| O95382 | MAP3K6 | S964 | ochoa|psp | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
| O95503 | CBX6 | S301 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| P08651 | NFIC | S464 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P10276 | RARA | S96 | psp | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P14317 | HCLS1 | S311 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P17600 | SYN1 | S568 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17600 | SYN1 | S665 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P20393 | NR1D1 | S278 | ochoa | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250|UniProtKB:Q3UV55, ECO:0000269|PubMed:12021280, ECO:0000269|PubMed:15761026, ECO:0000269|PubMed:16968709, ECO:0000269|PubMed:18006707, ECO:0000269|PubMed:19710360, ECO:0000269|PubMed:1971514, ECO:0000269|PubMed:21479263, ECO:0000269|PubMed:22184247, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:2539258}. |
| P22681 | CBL | Y552 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P22681 | CBL | S553 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23246 | SFPQ | S268 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25100 | ADRA1D | S492 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P26651 | ZFP36 | S90 | ochoa|psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P29474 | NOS3 | S56 | ochoa | Nitric oxide synthase 3 (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (NOS type III) (NOSIII) (Nitric oxide synthase, endothelial) (Endothelial NOS) (eNOS) | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000269|PubMed:1378832}.; FUNCTION: [Isoform eNOS13C]: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. |
| P30530 | AXL | S851 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P33076 | CIITA | S286 | psp | MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1) | Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215). {ECO:0000269|PubMed:11172716, ECO:0000269|PubMed:16600381, ECO:0000269|PubMed:17493635, ECO:0000269|PubMed:24036077, ECO:0000269|PubMed:32855215, ECO:0000269|PubMed:7749984, ECO:0000269|PubMed:8402893}.; FUNCTION: [Isoform 3]: Exhibits dominant-negative suppression of MHC class II gene expression. {ECO:0000269|PubMed:12919287}. |
| P41212 | ETV6 | S182 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P49406 | MRPL19 | S77 | ochoa | Large ribosomal subunit protein bL19m (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (39S ribosomal protein L19, mitochondrial) (L19mt) (MRP-L19) | None |
| P50548 | ERF | S154 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P50549 | ETV1 | S146 | psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
| P50570 | DNM2 | S848 | psp | Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:15731758, ECO:0000269|PubMed:17636067, ECO:0000269|PubMed:19605363, ECO:0000269|PubMed:19623537, ECO:0000269|PubMed:24135484, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:32315611, ECO:0000269|PubMed:33713620, ECO:0000269|PubMed:34744632, ECO:0000269|PubMed:36445308}. |
| P53992 | SEC24C | S308 | ochoa | Protein transport protein Sec24C (SEC24-related protein C) | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| P54259 | ATN1 | S645 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P58012 | FOXL2 | S326 | psp | Forkhead box protein L2 | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}. |
| Q01970 | PLCB3 | S926 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:20966218, PubMed:29122926, PubMed:37991948, PubMed:9188725). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation (PubMed:20966218, PubMed:37991948). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:P51432, ECO:0000269|PubMed:20966218, ECO:0000269|PubMed:29122926, ECO:0000269|PubMed:37991948, ECO:0000269|PubMed:9188725}. |
| Q05193 | DNM1 | S822 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
| Q07157 | TJP1 | S1446 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07912 | TNK2 | S793 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q07912 | TNK2 | S820 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q12815 | TROAP | S334 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13094 | LCP2 | S207 | ochoa|psp | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13094 | LCP2 | S417 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q14526 | HIC1 | S311 | ochoa | Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29) | Transcriptional repressor (PubMed:12052894, PubMed:15231840). Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840). May act as a tumor suppressor (PubMed:20154726). Involved in development of head, face, limbs and ventral body wall (By similarity). Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335). The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755). In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755). Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116). Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893). Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726). {ECO:0000250|UniProtKB:Q9R1Y5, ECO:0000269|PubMed:12052894, ECO:0000269|PubMed:15231840, ECO:0000269|PubMed:16269335, ECO:0000269|PubMed:16690027, ECO:0000269|PubMed:16724116, ECO:0000269|PubMed:18347096, ECO:0000269|PubMed:19486893, ECO:0000269|PubMed:19525223, ECO:0000269|PubMed:20154726, ECO:0000269|PubMed:20547755}. |
| Q14653 | IRF3 | S175 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14653 | IRF3 | S188 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14674 | ESPL1 | S1153 | psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14686 | NCOA6 | S1231 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14686 | NCOA6 | S1721 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14738 | PPP2R5D | S60 | ochoa|psp | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14738 | PPP2R5D | S62 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q14934 | NFATC4 | Y317 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14938 | NFIX | S454 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| Q15628 | TRADD | S215 | psp | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:23955153, PubMed:7758105, PubMed:8612133). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). {ECO:0000250|UniProtKB:Q3U0V2, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:7758105, ECO:0000269|PubMed:8612133}. |
| Q15654 | TRIP6 | S135 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15654 | TRIP6 | S147 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15772 | SPEG | S320 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15788 | NCOA1 | S1279 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q16643 | DBN1 | T389 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q16825 | PTPN21 | S588 | ochoa | Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1) | None |
| Q2KHR3 | QSER1 | S1197 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q32M88 | PGGHG | S698 | ochoa | Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1) | Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. {ECO:0000269|PubMed:26682924}. |
| Q3KQU3 | MAP7D1 | S116 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q53HC0 | CCDC92 | S211 | ochoa | Coiled-coil domain-containing protein 92 (Limkain beta-2) | Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}. |
| Q58A45 | PAN3 | S361 | ochoa | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}. |
| Q5FWE3 | PRRT3 | S815 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5VT52 | RPRD2 | S436 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q66K64 | DCAF15 | S310 | ochoa | DDB1- and CUL4-associated factor 15 | Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}. |
| Q6IQ23 | PLEKHA7 | S871 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NZY4 | ZCCHC8 | S498 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6UB99 | ANKRD11 | S1878 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWD8 | C16orf54 | S194 | ochoa | Transmembrane protein C16orf54 | None |
| Q6XZF7 | DNMBP | S620 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZRS2 | SRCAP | S349 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRS2 | SRCAP | S3020 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q70E73 | RAPH1 | S1094 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q711Q0 | CEFIP | S1248 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q76L83 | ASXL2 | S1319 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7KZI7 | MARK2 | S477 | ochoa | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617, ECO:0000269|PubMed:23666762}. |
| Q7Z406 | MYH14 | S35 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q7Z5L9 | IRF2BP2 | S409 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z5L9 | IRF2BP2 | S423 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z5R6 | APBB1IP | S526 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q7Z6I6 | ARHGAP30 | S480 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86UK7 | ZNF598 | S720 | ochoa | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32099016, PubMed:32579943, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32099016, PubMed:32579943, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:29719242, ECO:0000269|PubMed:30293783, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33581075, ECO:0000269|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269|PubMed:29719242}. |
| Q86UK7 | ZNF598 | S728 | ochoa | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32099016, PubMed:32579943, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32099016, PubMed:32579943, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:29719242, ECO:0000269|PubMed:30293783, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33581075, ECO:0000269|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269|PubMed:29719242}. |
| Q86YV0 | RASAL3 | S843 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IU81 | IRF2BP1 | S384 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IVT2 | MISP | S430 | ochoa|psp | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IWE5 | PLEKHM2 | S441 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8IYB3 | SRRM1 | S583 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S616 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S626 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S636 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S638 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8N3F8 | MICALL1 | S323 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4C8 | MINK1 | S674 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8NC96 | NECAP1 | S207 | ochoa | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | Involved in endocytosis. {ECO:0000250}. |
| Q8NCD3 | HJURP | S649 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NE35 | CPEB3 | S195 | ochoa | Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3) | Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}. |
| Q8TAP8 | PPP1R35 | S45 | ochoa | Protein phosphatase 1 regulatory subunit 35 | During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. |
| Q8TDM6 | DLG5 | S1021 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TF01 | PNISR | S211 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WUF5 | PPP1R13L | S183 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WXE0 | CASKIN2 | S1135 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q92558 | WASF1 | S489 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
| Q92918 | MAP4K1 | S407 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q96HA1 | POM121 | S184 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96I25 | RBM17 | S229 | ochoa | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}. |
| Q96IF1 | AJUBA | S196 | ochoa | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96JC9 | EAF1 | S158 | ochoa | ELL-associated factor 1 | Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:16006523}. |
| Q96JH8 | RADIL | S216 | ochoa | Ras-associating and dilute domain-containing protein | Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. {ECO:0000269|PubMed:17704304}. |
| Q96MM6 | HSPA12B | S44 | ochoa | Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B) | None |
| Q96PK6 | RBM14 | S225 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96S53 | TESK2 | S479 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
| Q96SN8 | CDK5RAP2 | S1020 | ochoa | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | Potential regulator of CDK5 activity via its interaction with CDK5R1 (PubMed:15164053). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (PubMed:19282672). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (PubMed:18042621, PubMed:17959831, PubMed:19553473). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (PubMed:18042621, PubMed:17959831, PubMed:26485573, PubMed:39321809). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:15164053, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:39321809}. |
| Q99501 | GAS2L1 | S352 | ochoa|psp | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q9BQI5 | SGIP1 | S493 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BR39 | JPH2 | S594 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BRQ0 | PYGO2 | S26 | ochoa | Pygopus homolog 2 | Involved in signal transduction through the Wnt pathway. |
| Q9BTU6 | PI4K2A | S24 | ochoa | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11279162, ECO:0000269|PubMed:16443754, ECO:0000269|PubMed:20388919, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:24675427, ECO:0000269|PubMed:25168678, ECO:0000305}. |
| Q9BY89 | KIAA1671 | S88 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZL4 | PPP1R12C | S509 | ochoa|psp | Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85) | Regulates myosin phosphatase activity. {ECO:0000269|PubMed:11399775}. |
| Q9C0C2 | TNKS1BP1 | S379 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S504 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0F6 | SHARPIN | S165 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9H2X6 | HIPK2 | S668 | psp | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H3P2 | NELFA | S353 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H4L4 | SENP3 | S44 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H6K5 | PRR36 | S1112 | ochoa | Proline-rich protein 36 | None |
| Q9H7D0 | DOCK5 | S1824 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
| Q9H7N4 | SCAF1 | S239 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8N7 | ZNF395 | S377 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9HBL0 | TNS1 | S963 | psp | Tensin-1 (EC 3.1.3.-) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}. |
| Q9HCH0 | NCKAP5L | S470 | psp | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}. |
| Q9HCM7 | FBRSL1 | S1017 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQC1 | JADE2 | S117 | ochoa | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}. |
| Q9NQC3 | RTN4 | S107 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQC3 | RTN4 | S115 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQU5 | PAK6 | S179 | ochoa | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NTJ3 | SMC4 | S41 | ochoa | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9NUE0 | ZDHHC18 | S53 | ochoa | Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}. |
| Q9NWA0 | MED9 | S53 | ochoa | Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| Q9P206 | NHSL3 | S858 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P242 | NYAP2 | S434 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P275 | USP36 | S763 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UGP5 | POLL | S177 | ochoa|psp | DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) | DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}. |
| Q9UKW4 | VAV3 | S604 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9UL51 | HCN2 | S868 | ochoa | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}. |
| Q9ULD4 | BRPF3 | S852 | ochoa | Bromodomain and PHD finger-containing protein 3 | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226). Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:26677226}. |
| Q9ULJ3 | ZBTB21 | S1008 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9ULU4 | ZMYND8 | S756 | ochoa | MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-containing protein 8) | Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed:26655721, PubMed:27477906, PubMed:31965980, PubMed:36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed:27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed:33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309, PubMed:27732854, PubMed:30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed:26655721, PubMed:30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed:26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed:30134174, PubMed:35916866, PubMed:36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed:27477906, PubMed:31965980, PubMed:33323928). {ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:26655721, ECO:0000269|PubMed:27477906, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:31965980, ECO:0000269|PubMed:33323928, ECO:0000269|PubMed:35916866, ECO:0000269|PubMed:36064715}. |
| Q9UMS6 | SYNPO2 | S637 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UMS6 | SYNPO2 | S781 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPN4 | CEP131 | S35 | ochoa|psp | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPS6 | SETD1B | S1431 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UQ35 | SRRM2 | S914 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y3L3 | SH3BP1 | S596 | ochoa | SH3 domain-binding protein 1 | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}. |
| Q9Y3Q8 | TSC22D4 | S49 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4F1 | FARP1 | S487 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4F5 | CEP170B | S1569 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4H2 | IRS2 | S1100 | ochoa|psp | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y4J8 | DTNA | S581 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y520 | PRRC2C | S2035 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y520 | PRRC2C | S2692 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y5S2 | CDC42BPB | S1640 | ochoa | Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}. |
| Q9Y6W5 | WASF2 | S343 | psp | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| O43488 | AKR7A2 | S40 | Sugiyama | Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1-AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase) | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}. |
| O15027 | SEC16A | Y1161 | Sugiyama | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| Q9NQU5 | PAK6 | S301 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.000584 | 3.233 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.001576 | 2.802 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003240 | 2.489 |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | 0.004994 | 2.302 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.050540 | 1.296 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.050540 | 1.296 |
| R-HSA-8941237 | Invadopodia formation | 0.050540 | 1.296 |
| R-HSA-1296061 | HCN channels | 0.060339 | 1.219 |
| R-HSA-74713 | IRS activation | 0.070037 | 1.155 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.070037 | 1.155 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.070037 | 1.155 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.070037 | 1.155 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.089137 | 1.050 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 0.098540 | 1.006 |
| R-HSA-112412 | SOS-mediated signalling | 0.098540 | 1.006 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.117058 | 0.932 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.030312 | 1.518 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.126174 | 0.899 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.135197 | 0.869 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.135197 | 0.869 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.135197 | 0.869 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.144127 | 0.841 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.144127 | 0.841 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.144127 | 0.841 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.152966 | 0.815 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.152966 | 0.815 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.152966 | 0.815 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.152966 | 0.815 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.152966 | 0.815 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.152966 | 0.815 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.046605 | 1.332 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.161714 | 0.791 |
| R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.161714 | 0.791 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.178941 | 0.747 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.178941 | 0.747 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.178941 | 0.747 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.178941 | 0.747 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.178941 | 0.747 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.187422 | 0.727 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.204124 | 0.690 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.212347 | 0.673 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.220485 | 0.657 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.220485 | 0.657 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.129043 | 0.889 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.290068 | 0.538 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.290068 | 0.538 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.297407 | 0.527 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.297407 | 0.527 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.304671 | 0.516 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.168318 | 0.774 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.168318 | 0.774 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.311861 | 0.506 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.179361 | 0.746 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.318977 | 0.496 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.332989 | 0.478 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.332989 | 0.478 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.205516 | 0.687 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.205516 | 0.687 |
| R-HSA-380287 | Centrosome maturation | 0.213067 | 0.671 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.224442 | 0.649 |
| R-HSA-1989781 | PPARA activates gene expression | 0.106722 | 0.972 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.239677 | 0.620 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.266440 | 0.574 |
| R-HSA-182971 | EGFR downregulation | 0.318977 | 0.496 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.110056 | 0.958 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.274093 | 0.562 |
| R-HSA-354192 | Integrin signaling | 0.332989 | 0.478 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.080055 | 1.097 |
| R-HSA-198203 | PI3K/AKT activation | 0.126174 | 0.899 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.228540 | 0.641 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.058943 | 1.230 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.058943 | 1.230 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.058943 | 1.230 |
| R-HSA-190873 | Gap junction degradation | 0.007094 | 2.149 |
| R-HSA-191650 | Regulation of gap junction activity | 0.060339 | 1.219 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.195816 | 0.708 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.132518 | 0.878 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.012554 | 1.901 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.194249 | 0.712 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.070037 | 1.155 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.089309 | 1.049 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.108683 | 0.964 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.195816 | 0.708 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.033465 | 1.475 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.033465 | 1.475 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.178941 | 0.747 |
| R-HSA-75893 | TNF signaling | 0.143070 | 0.844 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.282652 | 0.549 |
| R-HSA-9930044 | Nuclear RNA decay | 0.062556 | 1.204 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.062556 | 1.204 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.132518 | 0.878 |
| R-HSA-2424491 | DAP12 signaling | 0.054371 | 1.265 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.100934 | 0.996 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.034403 | 1.463 |
| R-HSA-196025 | Formation of annular gap junctions | 0.006002 | 2.222 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.007094 | 2.149 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.060339 | 1.219 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.107847 | 0.967 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.107847 | 0.967 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.024202 | 1.616 |
| R-HSA-4839744 | Signaling by APC mutants | 0.135197 | 0.869 |
| R-HSA-429947 | Deadenylation of mRNA | 0.039293 | 1.406 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.144127 | 0.841 |
| R-HSA-202670 | ERKs are inactivated | 0.144127 | 0.841 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.144127 | 0.841 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.068230 | 1.166 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.212347 | 0.673 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.212347 | 0.673 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.212347 | 0.673 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.326019 | 0.487 |
| R-HSA-9843745 | Adipogenesis | 0.196772 | 0.706 |
| R-HSA-68877 | Mitotic Prometaphase | 0.179321 | 0.746 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.209288 | 0.679 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.187422 | 0.727 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.112013 | 0.951 |
| R-HSA-177929 | Signaling by EGFR | 0.143070 | 0.844 |
| R-HSA-74749 | Signal attenuation | 0.126174 | 0.899 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.228540 | 0.641 |
| R-HSA-9707616 | Heme signaling | 0.006370 | 2.196 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.252210 | 0.598 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.297407 | 0.527 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.244401 | 0.612 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.117058 | 0.932 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.226189 | 0.646 |
| R-HSA-9664407 | Parasite infection | 0.223478 | 0.651 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.223478 | 0.651 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.223478 | 0.651 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.057055 | 1.244 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.212347 | 0.673 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.186783 | 0.729 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.074066 | 1.130 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.297407 | 0.527 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.304671 | 0.516 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.327410 | 0.485 |
| R-HSA-73887 | Death Receptor Signaling | 0.034403 | 1.463 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.015329 | 1.814 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.107847 | 0.967 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.144127 | 0.841 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.187422 | 0.727 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.071530 | 1.146 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.297407 | 0.527 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.304671 | 0.516 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.318977 | 0.496 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.332989 | 0.478 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.067675 | 1.170 |
| R-HSA-112040 | G-protein mediated events | 0.183066 | 0.737 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.201752 | 0.695 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.282652 | 0.549 |
| R-HSA-68886 | M Phase | 0.241789 | 0.617 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.195816 | 0.708 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.290068 | 0.538 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.332989 | 0.478 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.178941 | 0.747 |
| R-HSA-2172127 | DAP12 interactions | 0.102106 | 0.991 |
| R-HSA-9909396 | Circadian clock | 0.069215 | 1.160 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.144127 | 0.841 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.195816 | 0.708 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.061043 | 1.214 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.220485 | 0.657 |
| R-HSA-390696 | Adrenoceptors | 0.107847 | 0.967 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.107847 | 0.967 |
| R-HSA-428540 | Activation of RAC1 | 0.144127 | 0.841 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.022007 | 1.657 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.187422 | 0.727 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.187422 | 0.727 |
| R-HSA-163615 | PKA activation | 0.212347 | 0.673 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.259939 | 0.585 |
| R-HSA-9839394 | TGFBR3 expression | 0.275159 | 0.560 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.290068 | 0.538 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.006370 | 2.196 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.011566 | 1.937 |
| R-HSA-111885 | Opioid Signalling | 0.118293 | 0.927 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.282652 | 0.549 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.074066 | 1.130 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.150200 | 0.823 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.170942 | 0.767 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.195816 | 0.708 |
| R-HSA-194138 | Signaling by VEGF | 0.015922 | 1.798 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.323743 | 0.490 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.095645 | 1.019 |
| R-HSA-199991 | Membrane Trafficking | 0.158877 | 0.799 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.070037 | 1.155 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.009846 | 2.007 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.153792 | 0.813 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.157400 | 0.803 |
| R-HSA-3214847 | HATs acetylate histones | 0.107317 | 0.969 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.157400 | 0.803 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.213067 | 0.671 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.089309 | 1.049 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.041059 | 1.387 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.008062 | 2.094 |
| R-HSA-5578768 | Physiological factors | 0.170372 | 0.769 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.195816 | 0.708 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.259939 | 0.585 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.297407 | 0.527 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.318977 | 0.496 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.232052 | 0.634 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.318977 | 0.496 |
| R-HSA-190828 | Gap junction trafficking | 0.102106 | 0.991 |
| R-HSA-69275 | G2/M Transition | 0.165223 | 0.782 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.169209 | 0.772 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.070037 | 1.155 |
| R-HSA-9635465 | Suppression of apoptosis | 0.135197 | 0.869 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.228540 | 0.641 |
| R-HSA-198753 | ERK/MAPK targets | 0.236511 | 0.626 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.236511 | 0.626 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.143070 | 0.844 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.304671 | 0.516 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.332989 | 0.478 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.069729 | 1.157 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.032578 | 1.487 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.332989 | 0.478 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.236511 | 0.626 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.236511 | 0.626 |
| R-HSA-70171 | Glycolysis | 0.319840 | 0.495 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.044208 | 1.355 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.231629 | 0.635 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.170372 | 0.769 |
| R-HSA-112043 | PLC beta mediated events | 0.161024 | 0.793 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.311861 | 0.506 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.113853 | 0.944 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.213067 | 0.671 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.257180 | 0.590 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.332989 | 0.478 |
| R-HSA-162582 | Signal Transduction | 0.018482 | 1.733 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.278511 | 0.555 |
| R-HSA-1483255 | PI Metabolism | 0.030848 | 1.511 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.265766 | 0.576 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.044116 | 1.355 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.170372 | 0.769 |
| R-HSA-432142 | Platelet sensitization by LDL | 0.212347 | 0.673 |
| R-HSA-163685 | Integration of energy metabolism | 0.212704 | 0.672 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.022292 | 1.652 |
| R-HSA-2586552 | Signaling by Leptin | 0.126174 | 0.899 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.033383 | 1.476 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.107847 | 0.967 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.126174 | 0.899 |
| R-HSA-9842663 | Signaling by LTK | 0.152966 | 0.815 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.161714 | 0.791 |
| R-HSA-2559583 | Cellular Senescence | 0.153476 | 0.814 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.062737 | 1.202 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.282652 | 0.549 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.282652 | 0.549 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.090654 | 1.043 |
| R-HSA-877300 | Interferon gamma signaling | 0.113437 | 0.945 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.244401 | 0.612 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.290068 | 0.538 |
| R-HSA-180024 | DARPP-32 events | 0.304671 | 0.516 |
| R-HSA-74160 | Gene expression (Transcription) | 0.180328 | 0.744 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.125882 | 0.900 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.107317 | 0.969 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.074066 | 1.130 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.275159 | 0.560 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.275159 | 0.560 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.281490 | 0.551 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.077042 | 1.113 |
| R-HSA-437239 | Recycling pathway of L1 | 0.112013 | 0.951 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.252210 | 0.598 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.282652 | 0.549 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.168318 | 0.774 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.332989 | 0.478 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.062693 | 1.203 |
| R-HSA-4839726 | Chromatin organization | 0.149138 | 0.826 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.066190 | 1.179 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.304671 | 0.516 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.324495 | 0.489 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.205516 | 0.687 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.168318 | 0.774 |
| R-HSA-8848021 | Signaling by PTK6 | 0.168318 | 0.774 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.068230 | 1.166 |
| R-HSA-9690406 | Transcriptional regulation of testis differentiation | 0.195816 | 0.708 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.204124 | 0.690 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.204124 | 0.690 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.155956 | 0.807 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.095428 | 1.020 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.322714 | 0.491 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.161714 | 0.791 |
| R-HSA-166520 | Signaling by NTRKs | 0.095428 | 1.020 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.201752 | 0.695 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.074066 | 1.130 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.275159 | 0.560 |
| R-HSA-422475 | Axon guidance | 0.235545 | 0.628 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.175252 | 0.756 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.259939 | 0.585 |
| R-HSA-9675108 | Nervous system development | 0.289532 | 0.538 |
| R-HSA-2028269 | Signaling by Hippo | 0.204124 | 0.690 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.267588 | 0.573 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.332989 | 0.478 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.326019 | 0.487 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.334958 | 0.475 |
| R-HSA-9833110 | RSV-host interactions | 0.338723 | 0.470 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.339888 | 0.469 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.339888 | 0.469 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.339888 | 0.469 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.342482 | 0.465 |
| R-HSA-418346 | Platelet homeostasis | 0.346234 | 0.461 |
| R-HSA-203615 | eNOS activation | 0.346715 | 0.460 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.346715 | 0.460 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.346715 | 0.460 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.346715 | 0.460 |
| R-HSA-5673000 | RAF activation | 0.346715 | 0.460 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.346715 | 0.460 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.349147 | 0.457 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.353473 | 0.452 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.353473 | 0.452 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.358262 | 0.446 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.360161 | 0.444 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.360161 | 0.444 |
| R-HSA-111933 | Calmodulin induced events | 0.360161 | 0.444 |
| R-HSA-111997 | CaM pathway | 0.360161 | 0.444 |
| R-HSA-8853659 | RET signaling | 0.360161 | 0.444 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.360161 | 0.444 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.361169 | 0.442 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.361169 | 0.442 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.363839 | 0.439 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.366780 | 0.436 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.366780 | 0.436 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.366780 | 0.436 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.368591 | 0.433 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.373331 | 0.428 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.373331 | 0.428 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.375556 | 0.425 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.375979 | 0.425 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.379814 | 0.420 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.379814 | 0.420 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.379814 | 0.420 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.380060 | 0.420 |
| R-HSA-9658195 | Leishmania infection | 0.380239 | 0.420 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.380239 | 0.420 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.386231 | 0.413 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.386231 | 0.413 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.386231 | 0.413 |
| R-HSA-167169 | HIV Transcription Elongation | 0.386231 | 0.413 |
| R-HSA-202433 | Generation of second messenger molecules | 0.386231 | 0.413 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.386231 | 0.413 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.386231 | 0.413 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.386231 | 0.413 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.386231 | 0.413 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.386994 | 0.412 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.386994 | 0.412 |
| R-HSA-373760 | L1CAM interactions | 0.390647 | 0.408 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.391184 | 0.408 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.392582 | 0.406 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.392582 | 0.406 |
| R-HSA-9607240 | FLT3 Signaling | 0.392582 | 0.406 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 0.392582 | 0.406 |
| R-HSA-2262752 | Cellular responses to stress | 0.392964 | 0.406 |
| R-HSA-70326 | Glucose metabolism | 0.394291 | 0.404 |
| R-HSA-8953854 | Metabolism of RNA | 0.395956 | 0.402 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.398868 | 0.399 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.398868 | 0.399 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.398868 | 0.399 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.398931 | 0.399 |
| R-HSA-991365 | Activation of GABAB receptors | 0.405089 | 0.392 |
| R-HSA-977444 | GABA B receptor activation | 0.405089 | 0.392 |
| R-HSA-111996 | Ca-dependent events | 0.405089 | 0.392 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.405126 | 0.392 |
| R-HSA-68875 | Mitotic Prophase | 0.405162 | 0.392 |
| R-HSA-913531 | Interferon Signaling | 0.408647 | 0.389 |
| R-HSA-3371556 | Cellular response to heat stress | 0.408765 | 0.389 |
| R-HSA-72172 | mRNA Splicing | 0.410659 | 0.387 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.411246 | 0.386 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.411246 | 0.386 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.411246 | 0.386 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.411246 | 0.386 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.412893 | 0.384 |
| R-HSA-1483257 | Phospholipid metabolism | 0.412893 | 0.384 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.415214 | 0.382 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.415940 | 0.381 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.417340 | 0.380 |
| R-HSA-195721 | Signaling by WNT | 0.419850 | 0.377 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.423371 | 0.373 |
| R-HSA-774815 | Nucleosome assembly | 0.423371 | 0.373 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.423371 | 0.373 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.423371 | 0.373 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.423371 | 0.373 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.423371 | 0.373 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.423371 | 0.373 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.423371 | 0.373 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.429340 | 0.367 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.429340 | 0.367 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.429340 | 0.367 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.429340 | 0.367 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.429340 | 0.367 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.429340 | 0.367 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.429340 | 0.367 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.429340 | 0.367 |
| R-HSA-75153 | Apoptotic execution phase | 0.429340 | 0.367 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.441094 | 0.355 |
| R-HSA-9634597 | GPER1 signaling | 0.441094 | 0.355 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.441094 | 0.355 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.441094 | 0.355 |
| R-HSA-68882 | Mitotic Anaphase | 0.443504 | 0.353 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.444193 | 0.352 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.446211 | 0.350 |
| R-HSA-9766229 | Degradation of CDH1 | 0.446880 | 0.350 |
| R-HSA-1474165 | Reproduction | 0.447672 | 0.349 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.452607 | 0.344 |
| R-HSA-109704 | PI3K Cascade | 0.452607 | 0.344 |
| R-HSA-9748787 | Azathioprine ADME | 0.452607 | 0.344 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.458275 | 0.339 |
| R-HSA-9864848 | Complex IV assembly | 0.458275 | 0.339 |
| R-HSA-72187 | mRNA 3'-end processing | 0.463885 | 0.334 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.463885 | 0.334 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.463885 | 0.334 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.475057 | 0.323 |
| R-HSA-418597 | G alpha (z) signalling events | 0.480370 | 0.318 |
| R-HSA-6807070 | PTEN Regulation | 0.481776 | 0.317 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.485752 | 0.314 |
| R-HSA-1640170 | Cell Cycle | 0.486061 | 0.313 |
| R-HSA-112399 | IRS-mediated signalling | 0.491079 | 0.309 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.491079 | 0.309 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.491079 | 0.309 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.491079 | 0.309 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.495054 | 0.305 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.496351 | 0.304 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.501568 | 0.300 |
| R-HSA-191859 | snRNP Assembly | 0.501568 | 0.300 |
| R-HSA-977443 | GABA receptor activation | 0.506732 | 0.295 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.511348 | 0.291 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.511843 | 0.291 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.511843 | 0.291 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.511843 | 0.291 |
| R-HSA-211976 | Endogenous sterols | 0.511843 | 0.291 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.511843 | 0.291 |
| R-HSA-450294 | MAP kinase activation | 0.511843 | 0.291 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.516901 | 0.287 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.516901 | 0.287 |
| R-HSA-373755 | Semaphorin interactions | 0.521907 | 0.282 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.526862 | 0.278 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.526862 | 0.278 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.529654 | 0.276 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.531765 | 0.274 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.531765 | 0.274 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.531765 | 0.274 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.533577 | 0.273 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.533934 | 0.273 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.541421 | 0.266 |
| R-HSA-162587 | HIV Life Cycle | 0.542892 | 0.265 |
| R-HSA-167172 | Transcription of the HIV genome | 0.546174 | 0.263 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.546174 | 0.263 |
| R-HSA-5218859 | Regulated Necrosis | 0.546174 | 0.263 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.552077 | 0.258 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.555535 | 0.255 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.555535 | 0.255 |
| R-HSA-448424 | Interleukin-17 signaling | 0.555535 | 0.255 |
| R-HSA-109581 | Apoptosis | 0.558129 | 0.253 |
| R-HSA-8978934 | Metabolism of cofactors | 0.560143 | 0.252 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.563343 | 0.249 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.564123 | 0.249 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.564703 | 0.248 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.564703 | 0.248 |
| R-HSA-4086398 | Ca2+ pathway | 0.569217 | 0.245 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.573683 | 0.241 |
| R-HSA-112316 | Neuronal System | 0.574786 | 0.240 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.575845 | 0.240 |
| R-HSA-5689603 | UCH proteinases | 0.582480 | 0.235 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.586810 | 0.232 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.591095 | 0.228 |
| R-HSA-9659379 | Sensory processing of sound | 0.595337 | 0.225 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.599535 | 0.222 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.599535 | 0.222 |
| R-HSA-6806834 | Signaling by MET | 0.599535 | 0.222 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.615006 | 0.211 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.619882 | 0.208 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.619882 | 0.208 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.623827 | 0.205 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.623827 | 0.205 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.627731 | 0.202 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.627731 | 0.202 |
| R-HSA-70268 | Pyruvate metabolism | 0.631594 | 0.200 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.635418 | 0.197 |
| R-HSA-5617833 | Cilium Assembly | 0.639325 | 0.194 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.642947 | 0.192 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.646654 | 0.189 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.653953 | 0.184 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.655608 | 0.183 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.661102 | 0.180 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.664621 | 0.177 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.664621 | 0.177 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.669348 | 0.174 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.671550 | 0.173 |
| R-HSA-1296071 | Potassium Channels | 0.671550 | 0.173 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.671757 | 0.173 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.674962 | 0.171 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.678338 | 0.169 |
| R-HSA-190236 | Signaling by FGFR | 0.678338 | 0.169 |
| R-HSA-422356 | Regulation of insulin secretion | 0.678338 | 0.169 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.678338 | 0.169 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.678338 | 0.169 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.678338 | 0.169 |
| R-HSA-5357801 | Programmed Cell Death | 0.678900 | 0.168 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.681679 | 0.166 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.684986 | 0.164 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.684986 | 0.164 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.688258 | 0.162 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.691497 | 0.160 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.692620 | 0.160 |
| R-HSA-8957322 | Metabolism of steroids | 0.694502 | 0.158 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.694703 | 0.158 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.695077 | 0.158 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.707196 | 0.150 |
| R-HSA-1474244 | Extracellular matrix organization | 0.707436 | 0.150 |
| R-HSA-211000 | Gene Silencing by RNA | 0.710239 | 0.149 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.713251 | 0.147 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.716232 | 0.145 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.716232 | 0.145 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.716232 | 0.145 |
| R-HSA-202403 | TCR signaling | 0.719182 | 0.143 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.719182 | 0.143 |
| R-HSA-162906 | HIV Infection | 0.727489 | 0.138 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.727849 | 0.138 |
| R-HSA-109582 | Hemostasis | 0.734016 | 0.134 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.736251 | 0.133 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.736251 | 0.133 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.747054 | 0.127 |
| R-HSA-8939211 | ESR-mediated signaling | 0.747451 | 0.126 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.749685 | 0.125 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.749685 | 0.125 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.749685 | 0.125 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.754866 | 0.122 |
| R-HSA-73886 | Chromosome Maintenance | 0.754866 | 0.122 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.754866 | 0.122 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.757417 | 0.121 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.757417 | 0.121 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.759941 | 0.119 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.762439 | 0.118 |
| R-HSA-212436 | Generic Transcription Pathway | 0.763288 | 0.117 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.769779 | 0.114 |
| R-HSA-114608 | Platelet degranulation | 0.772175 | 0.112 |
| R-HSA-5576891 | Cardiac conduction | 0.783789 | 0.106 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.788268 | 0.103 |
| R-HSA-416476 | G alpha (q) signalling events | 0.795203 | 0.100 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.796951 | 0.099 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.796951 | 0.099 |
| R-HSA-5368287 | Mitochondrial translation | 0.801159 | 0.096 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.801159 | 0.096 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.801159 | 0.096 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.807537 | 0.093 |
| R-HSA-418594 | G alpha (i) signalling events | 0.823211 | 0.084 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.831847 | 0.080 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.835335 | 0.078 |
| R-HSA-388396 | GPCR downstream signalling | 0.836970 | 0.077 |
| R-HSA-9610379 | HCMV Late Events | 0.838752 | 0.076 |
| R-HSA-9679506 | SARS-CoV Infections | 0.851282 | 0.070 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.854807 | 0.068 |
| R-HSA-5619102 | SLC transporter disorders | 0.854807 | 0.068 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.860775 | 0.065 |
| R-HSA-72306 | tRNA processing | 0.860775 | 0.065 |
| R-HSA-418555 | G alpha (s) signalling events | 0.862228 | 0.064 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.865090 | 0.063 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.865090 | 0.063 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.865090 | 0.063 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.865090 | 0.063 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.867893 | 0.062 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.867893 | 0.062 |
| R-HSA-611105 | Respiratory electron transport | 0.871989 | 0.059 |
| R-HSA-168255 | Influenza Infection | 0.873326 | 0.059 |
| R-HSA-1266738 | Developmental Biology | 0.879613 | 0.056 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.884751 | 0.053 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.890481 | 0.050 |
| R-HSA-9609690 | HCMV Early Events | 0.894044 | 0.049 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.894044 | 0.049 |
| R-HSA-372790 | Signaling by GPCR | 0.897132 | 0.047 |
| R-HSA-449147 | Signaling by Interleukins | 0.905772 | 0.043 |
| R-HSA-397014 | Muscle contraction | 0.911390 | 0.040 |
| R-HSA-9748784 | Drug ADME | 0.916812 | 0.038 |
| R-HSA-418990 | Adherens junctions interactions | 0.916812 | 0.038 |
| R-HSA-72312 | rRNA processing | 0.928216 | 0.032 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.928363 | 0.032 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.938714 | 0.027 |
| R-HSA-9609646 | HCMV Infection | 0.940622 | 0.027 |
| R-HSA-421270 | Cell-cell junction organization | 0.941246 | 0.026 |
| R-HSA-5688426 | Deubiquitination | 0.943673 | 0.025 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.944264 | 0.025 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.945428 | 0.024 |
| R-HSA-168249 | Innate Immune System | 0.945641 | 0.024 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.945737 | 0.024 |
| R-HSA-5663205 | Infectious disease | 0.948525 | 0.023 |
| R-HSA-72766 | Translation | 0.948965 | 0.023 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.955818 | 0.020 |
| R-HSA-446728 | Cell junction organization | 0.955818 | 0.020 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.959432 | 0.018 |
| R-HSA-1500931 | Cell-Cell communication | 0.970443 | 0.013 |
| R-HSA-211859 | Biological oxidations | 0.977996 | 0.010 |
| R-HSA-556833 | Metabolism of lipids | 0.978407 | 0.009 |
| R-HSA-73894 | DNA Repair | 0.981466 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 0.981658 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.982237 | 0.008 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.985639 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.987225 | 0.006 |
| R-HSA-1280218 | Adaptive Immune System | 0.987768 | 0.005 |
| R-HSA-597592 | Post-translational protein modification | 0.992747 | 0.003 |
| R-HSA-1643685 | Disease | 0.995204 | 0.002 |
| R-HSA-168256 | Immune System | 0.996580 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998418 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.999771 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999978 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999990 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.860 | 0.683 | 1 | 0.907 |
HIPK4 |
0.855 | 0.676 | 1 | 0.883 |
CLK3 |
0.854 | 0.538 | 1 | 0.886 |
KIS |
0.848 | 0.536 | 1 | 0.939 |
SRPK1 |
0.847 | 0.502 | -3 | 0.865 |
DYRK2 |
0.847 | 0.639 | 1 | 0.929 |
CLK2 |
0.846 | 0.529 | -3 | 0.862 |
DYRK4 |
0.841 | 0.610 | 1 | 0.920 |
HIPK1 |
0.840 | 0.636 | 1 | 0.934 |
MAK |
0.836 | 0.647 | -2 | 0.850 |
SRPK2 |
0.833 | 0.449 | -3 | 0.833 |
DYRK1A |
0.832 | 0.618 | 1 | 0.938 |
NDR2 |
0.830 | 0.305 | -3 | 0.843 |
CDK18 |
0.829 | 0.522 | 1 | 0.913 |
ICK |
0.829 | 0.560 | -3 | 0.860 |
CDKL5 |
0.828 | 0.448 | -3 | 0.860 |
CLK4 |
0.828 | 0.473 | -3 | 0.857 |
CDK7 |
0.827 | 0.506 | 1 | 0.943 |
DYRK1B |
0.827 | 0.572 | 1 | 0.919 |
PRKD1 |
0.826 | 0.364 | -3 | 0.836 |
CDK19 |
0.826 | 0.508 | 1 | 0.918 |
PIM3 |
0.826 | 0.320 | -3 | 0.866 |
PRKD2 |
0.825 | 0.364 | -3 | 0.841 |
RSK2 |
0.824 | 0.336 | -3 | 0.868 |
CLK1 |
0.824 | 0.475 | -3 | 0.836 |
CDKL1 |
0.823 | 0.446 | -3 | 0.856 |
JNK2 |
0.823 | 0.521 | 1 | 0.927 |
HIPK3 |
0.823 | 0.600 | 1 | 0.925 |
CDK8 |
0.822 | 0.486 | 1 | 0.930 |
DYRK3 |
0.822 | 0.539 | 1 | 0.915 |
CDK1 |
0.821 | 0.467 | 1 | 0.923 |
SRPK3 |
0.821 | 0.387 | -3 | 0.836 |
MAPKAPK2 |
0.820 | 0.328 | -3 | 0.838 |
P38B |
0.820 | 0.538 | 1 | 0.916 |
P90RSK |
0.819 | 0.339 | -3 | 0.870 |
PIM1 |
0.818 | 0.332 | -3 | 0.862 |
NLK |
0.817 | 0.440 | 1 | 0.926 |
CDK17 |
0.816 | 0.489 | 1 | 0.885 |
P38G |
0.816 | 0.497 | 1 | 0.887 |
AURC |
0.816 | 0.213 | -2 | 0.637 |
ERK1 |
0.816 | 0.499 | 1 | 0.920 |
RSK4 |
0.816 | 0.326 | -3 | 0.874 |
CDK10 |
0.815 | 0.491 | 1 | 0.925 |
PKACB |
0.815 | 0.283 | -2 | 0.642 |
PRKX |
0.814 | 0.295 | -3 | 0.835 |
MTOR |
0.814 | 0.202 | 1 | 0.793 |
COT |
0.814 | 0.052 | 2 | 0.791 |
P38A |
0.814 | 0.516 | 1 | 0.939 |
CDK13 |
0.814 | 0.446 | 1 | 0.933 |
JNK3 |
0.813 | 0.480 | 1 | 0.933 |
MOS |
0.813 | 0.197 | 1 | 0.761 |
SKMLCK |
0.813 | 0.253 | -2 | 0.831 |
CDK3 |
0.812 | 0.421 | 1 | 0.897 |
CDK12 |
0.811 | 0.459 | 1 | 0.922 |
RSK3 |
0.811 | 0.290 | -3 | 0.851 |
NDR1 |
0.811 | 0.213 | -3 | 0.840 |
CDC7 |
0.811 | 0.093 | 1 | 0.719 |
CDK5 |
0.811 | 0.443 | 1 | 0.942 |
CDK14 |
0.811 | 0.499 | 1 | 0.930 |
MOK |
0.810 | 0.570 | 1 | 0.886 |
P38D |
0.809 | 0.508 | 1 | 0.893 |
ERK5 |
0.809 | 0.272 | 1 | 0.859 |
MAPKAPK3 |
0.809 | 0.286 | -3 | 0.821 |
LATS2 |
0.807 | 0.176 | -5 | 0.688 |
CAMK1B |
0.807 | 0.242 | -3 | 0.828 |
CDK16 |
0.806 | 0.461 | 1 | 0.894 |
AKT2 |
0.806 | 0.331 | -3 | 0.835 |
CDK9 |
0.806 | 0.439 | 1 | 0.936 |
PKACG |
0.806 | 0.199 | -2 | 0.712 |
CAMK2A |
0.806 | 0.238 | 2 | 0.765 |
GRK1 |
0.806 | 0.137 | -2 | 0.818 |
MSK1 |
0.805 | 0.269 | -3 | 0.837 |
P70S6KB |
0.804 | 0.253 | -3 | 0.840 |
NUAK2 |
0.803 | 0.210 | -3 | 0.851 |
PRKD3 |
0.802 | 0.301 | -3 | 0.828 |
MSK2 |
0.802 | 0.254 | -3 | 0.844 |
CAMK2D |
0.801 | 0.173 | -3 | 0.795 |
IKKB |
0.801 | -0.022 | -2 | 0.690 |
PKN3 |
0.800 | 0.182 | -3 | 0.823 |
PRPK |
0.799 | -0.000 | -1 | 0.822 |
CAMLCK |
0.799 | 0.209 | -2 | 0.796 |
ATR |
0.798 | 0.064 | 1 | 0.727 |
RAF1 |
0.798 | -0.002 | 1 | 0.730 |
CAMK2B |
0.797 | 0.159 | 2 | 0.738 |
LATS1 |
0.797 | 0.240 | -3 | 0.844 |
DAPK2 |
0.797 | 0.232 | -3 | 0.821 |
ERK2 |
0.797 | 0.430 | 1 | 0.930 |
GRK7 |
0.797 | 0.132 | 1 | 0.692 |
AMPKA2 |
0.796 | 0.195 | -3 | 0.834 |
PIM2 |
0.796 | 0.299 | -3 | 0.841 |
JNK1 |
0.796 | 0.425 | 1 | 0.913 |
PKACA |
0.796 | 0.252 | -2 | 0.594 |
PAK1 |
0.796 | 0.148 | -2 | 0.768 |
AMPKA1 |
0.795 | 0.146 | -3 | 0.826 |
SGK3 |
0.794 | 0.253 | -3 | 0.829 |
TBK1 |
0.794 | -0.035 | 1 | 0.646 |
WNK1 |
0.794 | 0.056 | -2 | 0.845 |
PKN2 |
0.794 | 0.116 | -3 | 0.807 |
MST4 |
0.794 | 0.042 | 2 | 0.798 |
NIK |
0.793 | 0.150 | -3 | 0.790 |
IKKA |
0.792 | -0.002 | -2 | 0.691 |
MNK2 |
0.792 | 0.123 | -2 | 0.745 |
PKG2 |
0.792 | 0.179 | -2 | 0.644 |
PKCD |
0.791 | 0.135 | 2 | 0.685 |
PRP4 |
0.791 | 0.294 | -3 | 0.653 |
CHAK2 |
0.791 | 0.026 | -1 | 0.789 |
AURB |
0.790 | 0.134 | -2 | 0.632 |
MNK1 |
0.790 | 0.138 | -2 | 0.752 |
PDHK4 |
0.790 | -0.163 | 1 | 0.766 |
PASK |
0.790 | 0.271 | -3 | 0.857 |
TSSK1 |
0.790 | 0.142 | -3 | 0.833 |
IKKE |
0.790 | -0.070 | 1 | 0.641 |
GCN2 |
0.789 | -0.130 | 2 | 0.736 |
SBK |
0.789 | 0.395 | -3 | 0.776 |
SGK1 |
0.789 | 0.331 | -3 | 0.807 |
GRK5 |
0.788 | -0.067 | -3 | 0.697 |
AKT3 |
0.788 | 0.314 | -3 | 0.821 |
BMPR2 |
0.788 | -0.139 | -2 | 0.806 |
GSK3A |
0.787 | 0.202 | 4 | 0.544 |
MARK4 |
0.787 | 0.024 | 4 | 0.784 |
AURA |
0.787 | 0.112 | -2 | 0.613 |
CAMK2G |
0.787 | -0.087 | 2 | 0.752 |
MYLK4 |
0.787 | 0.174 | -2 | 0.729 |
PAK3 |
0.787 | 0.101 | -2 | 0.749 |
PKCB |
0.786 | 0.113 | 2 | 0.640 |
CDK4 |
0.786 | 0.444 | 1 | 0.916 |
DCAMKL1 |
0.786 | 0.223 | -3 | 0.839 |
AKT1 |
0.785 | 0.263 | -3 | 0.836 |
QSK |
0.785 | 0.126 | 4 | 0.753 |
PAK6 |
0.785 | 0.121 | -2 | 0.658 |
CDK2 |
0.784 | 0.268 | 1 | 0.925 |
TGFBR2 |
0.784 | -0.033 | -2 | 0.708 |
RIPK3 |
0.784 | -0.075 | 3 | 0.611 |
MASTL |
0.784 | -0.057 | -2 | 0.767 |
PKCA |
0.784 | 0.108 | 2 | 0.628 |
NEK6 |
0.784 | -0.065 | -2 | 0.757 |
PHKG1 |
0.784 | 0.122 | -3 | 0.825 |
CAMK4 |
0.784 | 0.085 | -3 | 0.804 |
BMPR1B |
0.783 | 0.041 | 1 | 0.681 |
PKCG |
0.783 | 0.084 | 2 | 0.640 |
SIK |
0.782 | 0.161 | -3 | 0.812 |
MPSK1 |
0.782 | 0.242 | 1 | 0.722 |
MELK |
0.782 | 0.147 | -3 | 0.819 |
MLK2 |
0.782 | 0.012 | 2 | 0.739 |
BRSK1 |
0.782 | 0.133 | -3 | 0.824 |
TSSK2 |
0.782 | 0.053 | -5 | 0.824 |
CDK6 |
0.781 | 0.399 | 1 | 0.923 |
NUAK1 |
0.781 | 0.146 | -3 | 0.824 |
PDHK1 |
0.781 | -0.171 | 1 | 0.744 |
P70S6K |
0.781 | 0.237 | -3 | 0.809 |
DSTYK |
0.780 | -0.173 | 2 | 0.813 |
DLK |
0.780 | -0.041 | 1 | 0.720 |
MAPKAPK5 |
0.780 | 0.191 | -3 | 0.794 |
PKCZ |
0.779 | 0.076 | 2 | 0.682 |
PAK2 |
0.779 | 0.081 | -2 | 0.748 |
GRK6 |
0.778 | -0.081 | 1 | 0.715 |
MLK1 |
0.777 | -0.148 | 2 | 0.725 |
NIM1 |
0.777 | 0.008 | 3 | 0.643 |
ULK2 |
0.777 | -0.213 | 2 | 0.692 |
HUNK |
0.777 | -0.137 | 2 | 0.754 |
CAMK1D |
0.777 | 0.250 | -3 | 0.801 |
CK1E |
0.776 | 0.018 | -3 | 0.498 |
CHK1 |
0.776 | 0.110 | -3 | 0.791 |
CAMK1G |
0.776 | 0.174 | -3 | 0.821 |
TGFBR1 |
0.776 | -0.007 | -2 | 0.731 |
GRK4 |
0.776 | -0.114 | -2 | 0.798 |
BRSK2 |
0.775 | 0.074 | -3 | 0.796 |
BCKDK |
0.775 | -0.137 | -1 | 0.747 |
MLK3 |
0.775 | -0.021 | 2 | 0.651 |
RIPK1 |
0.775 | -0.093 | 1 | 0.690 |
ALK4 |
0.775 | -0.026 | -2 | 0.755 |
NEK7 |
0.775 | -0.208 | -3 | 0.698 |
DNAPK |
0.774 | 0.014 | 1 | 0.639 |
GSK3B |
0.774 | 0.104 | 4 | 0.537 |
PKCH |
0.773 | 0.057 | 2 | 0.617 |
QIK |
0.772 | 0.007 | -3 | 0.789 |
ATM |
0.772 | -0.055 | 1 | 0.663 |
MARK3 |
0.771 | 0.037 | 4 | 0.708 |
IRE1 |
0.771 | -0.071 | 1 | 0.672 |
VRK2 |
0.771 | 0.024 | 1 | 0.788 |
CHK2 |
0.771 | 0.277 | -3 | 0.799 |
FAM20C |
0.771 | -0.026 | 2 | 0.571 |
WNK3 |
0.770 | -0.191 | 1 | 0.702 |
ROCK2 |
0.770 | 0.256 | -3 | 0.837 |
TLK2 |
0.770 | -0.035 | 1 | 0.672 |
CK1D |
0.770 | 0.031 | -3 | 0.446 |
PKR |
0.770 | -0.030 | 1 | 0.718 |
MST3 |
0.769 | 0.040 | 2 | 0.774 |
PAK5 |
0.769 | 0.103 | -2 | 0.633 |
YSK4 |
0.769 | -0.083 | 1 | 0.677 |
TTBK2 |
0.769 | -0.154 | 2 | 0.631 |
DAPK3 |
0.769 | 0.197 | -3 | 0.848 |
NEK9 |
0.768 | -0.181 | 2 | 0.751 |
PAK4 |
0.768 | 0.107 | -2 | 0.641 |
MRCKA |
0.768 | 0.224 | -3 | 0.818 |
BUB1 |
0.768 | 0.245 | -5 | 0.787 |
MRCKB |
0.768 | 0.234 | -3 | 0.814 |
ERK7 |
0.768 | 0.136 | 2 | 0.473 |
DCAMKL2 |
0.768 | 0.115 | -3 | 0.831 |
SMMLCK |
0.768 | 0.155 | -3 | 0.823 |
CRIK |
0.767 | 0.302 | -3 | 0.843 |
MEK1 |
0.767 | -0.109 | 2 | 0.786 |
PKCE |
0.767 | 0.139 | 2 | 0.626 |
DAPK1 |
0.767 | 0.194 | -3 | 0.848 |
ANKRD3 |
0.767 | -0.183 | 1 | 0.735 |
SMG1 |
0.767 | -0.055 | 1 | 0.681 |
GRK2 |
0.766 | -0.044 | -2 | 0.702 |
TAO3 |
0.766 | 0.039 | 1 | 0.713 |
ALK2 |
0.765 | -0.046 | -2 | 0.736 |
DRAK1 |
0.765 | -0.026 | 1 | 0.656 |
CAMK1A |
0.765 | 0.254 | -3 | 0.796 |
ULK1 |
0.765 | -0.237 | -3 | 0.636 |
PKCT |
0.764 | 0.083 | 2 | 0.622 |
ACVR2B |
0.764 | -0.071 | -2 | 0.706 |
DMPK1 |
0.763 | 0.258 | -3 | 0.832 |
CK1A2 |
0.763 | -0.000 | -3 | 0.457 |
CK1G1 |
0.763 | -0.030 | -3 | 0.482 |
MARK2 |
0.762 | -0.011 | 4 | 0.675 |
PKN1 |
0.761 | 0.180 | -3 | 0.813 |
ACVR2A |
0.761 | -0.089 | -2 | 0.692 |
CHAK1 |
0.760 | -0.127 | 2 | 0.701 |
SSTK |
0.760 | 0.033 | 4 | 0.736 |
WNK4 |
0.760 | -0.031 | -2 | 0.829 |
PLK1 |
0.760 | -0.168 | -2 | 0.694 |
GCK |
0.760 | 0.073 | 1 | 0.713 |
LKB1 |
0.759 | 0.081 | -3 | 0.686 |
NEK2 |
0.759 | -0.129 | 2 | 0.733 |
MLK4 |
0.759 | -0.125 | 2 | 0.627 |
MEK5 |
0.759 | -0.126 | 2 | 0.750 |
PKCI |
0.758 | 0.051 | 2 | 0.649 |
GAK |
0.758 | 0.045 | 1 | 0.764 |
MARK1 |
0.758 | -0.015 | 4 | 0.722 |
GRK3 |
0.758 | -0.040 | -2 | 0.676 |
SNRK |
0.758 | -0.065 | 2 | 0.592 |
PDK1 |
0.758 | 0.092 | 1 | 0.700 |
BMPR1A |
0.757 | -0.035 | 1 | 0.656 |
IRE2 |
0.757 | -0.109 | 2 | 0.629 |
PLK3 |
0.755 | -0.152 | 2 | 0.719 |
HPK1 |
0.755 | 0.050 | 1 | 0.703 |
MEKK3 |
0.755 | -0.169 | 1 | 0.704 |
PINK1 |
0.754 | -0.045 | 1 | 0.815 |
PHKG2 |
0.754 | 0.032 | -3 | 0.797 |
NEK5 |
0.754 | -0.100 | 1 | 0.706 |
PLK4 |
0.754 | -0.135 | 2 | 0.555 |
PBK |
0.754 | 0.113 | 1 | 0.700 |
MEKK2 |
0.753 | -0.129 | 2 | 0.717 |
PERK |
0.753 | -0.133 | -2 | 0.740 |
BRAF |
0.752 | -0.115 | -4 | 0.775 |
ROCK1 |
0.752 | 0.211 | -3 | 0.818 |
ZAK |
0.751 | -0.160 | 1 | 0.672 |
NEK11 |
0.751 | -0.096 | 1 | 0.701 |
KHS1 |
0.750 | 0.077 | 1 | 0.690 |
TLK1 |
0.750 | -0.140 | -2 | 0.756 |
PKG1 |
0.750 | 0.145 | -2 | 0.565 |
KHS2 |
0.750 | 0.068 | 1 | 0.708 |
TNIK |
0.749 | 0.027 | 3 | 0.760 |
MAP3K15 |
0.749 | 0.001 | 1 | 0.673 |
MEKK1 |
0.749 | -0.190 | 1 | 0.700 |
LOK |
0.748 | 0.032 | -2 | 0.719 |
IRAK4 |
0.748 | -0.119 | 1 | 0.668 |
MEKK6 |
0.747 | -0.023 | 1 | 0.698 |
SLK |
0.747 | 0.011 | -2 | 0.697 |
TAO2 |
0.747 | -0.071 | 2 | 0.753 |
LRRK2 |
0.745 | -0.001 | 2 | 0.764 |
CAMKK2 |
0.745 | -0.076 | -2 | 0.678 |
CK2A2 |
0.745 | -0.047 | 1 | 0.595 |
PDHK3_TYR |
0.744 | 0.283 | 4 | 0.869 |
HGK |
0.744 | -0.040 | 3 | 0.752 |
HRI |
0.744 | -0.241 | -2 | 0.750 |
TAK1 |
0.742 | -0.081 | 1 | 0.708 |
MINK |
0.742 | -0.068 | 1 | 0.688 |
NEK8 |
0.741 | -0.146 | 2 | 0.723 |
HASPIN |
0.741 | 0.061 | -1 | 0.685 |
MST2 |
0.740 | -0.127 | 1 | 0.704 |
CK1A |
0.740 | -0.000 | -3 | 0.375 |
NEK4 |
0.739 | -0.116 | 1 | 0.682 |
CAMKK1 |
0.739 | -0.196 | -2 | 0.671 |
CK2A1 |
0.739 | -0.043 | 1 | 0.576 |
NEK1 |
0.738 | -0.069 | 1 | 0.683 |
EEF2K |
0.737 | -0.104 | 3 | 0.686 |
LIMK2_TYR |
0.736 | 0.247 | -3 | 0.760 |
PDHK4_TYR |
0.736 | 0.134 | 2 | 0.825 |
TTBK1 |
0.735 | -0.195 | 2 | 0.551 |
MAP2K4_TYR |
0.735 | 0.191 | -1 | 0.824 |
PLK2 |
0.734 | -0.095 | -3 | 0.617 |
YANK3 |
0.734 | -0.026 | 2 | 0.378 |
VRK1 |
0.733 | -0.139 | 2 | 0.733 |
TESK1_TYR |
0.733 | 0.144 | 3 | 0.779 |
STK33 |
0.732 | -0.127 | 2 | 0.556 |
MAP2K6_TYR |
0.732 | 0.096 | -1 | 0.824 |
OSR1 |
0.731 | -0.039 | 2 | 0.736 |
MST1 |
0.731 | -0.129 | 1 | 0.685 |
PKMYT1_TYR |
0.731 | 0.131 | 3 | 0.750 |
YSK1 |
0.731 | -0.088 | 2 | 0.726 |
MAP2K7_TYR |
0.726 | -0.029 | 2 | 0.788 |
IRAK1 |
0.726 | -0.306 | -1 | 0.704 |
PDHK1_TYR |
0.726 | 0.004 | -1 | 0.821 |
BMPR2_TYR |
0.725 | 0.003 | -1 | 0.808 |
BIKE |
0.723 | 0.013 | 1 | 0.679 |
MEK2 |
0.723 | -0.219 | 2 | 0.741 |
MYO3B |
0.721 | -0.047 | 2 | 0.744 |
ASK1 |
0.720 | -0.082 | 1 | 0.663 |
PINK1_TYR |
0.718 | -0.104 | 1 | 0.748 |
RET |
0.718 | -0.032 | 1 | 0.707 |
RIPK2 |
0.718 | -0.248 | 1 | 0.636 |
TAO1 |
0.718 | -0.070 | 1 | 0.643 |
TTK |
0.717 | -0.120 | -2 | 0.734 |
NEK3 |
0.717 | -0.146 | 1 | 0.664 |
AAK1 |
0.717 | 0.068 | 1 | 0.610 |
ABL2 |
0.716 | 0.046 | -1 | 0.752 |
LIMK1_TYR |
0.715 | -0.035 | 2 | 0.762 |
TXK |
0.715 | 0.020 | 1 | 0.707 |
ALPHAK3 |
0.715 | -0.085 | -1 | 0.710 |
EPHB4 |
0.715 | -0.014 | -1 | 0.765 |
MST1R |
0.712 | -0.062 | 3 | 0.702 |
ABL1 |
0.712 | 0.023 | -1 | 0.747 |
FGR |
0.712 | -0.057 | 1 | 0.727 |
TNK2 |
0.712 | 0.005 | 3 | 0.642 |
MYO3A |
0.711 | -0.118 | 1 | 0.679 |
EPHA6 |
0.711 | -0.057 | -1 | 0.783 |
CSF1R |
0.710 | -0.062 | 3 | 0.680 |
DDR1 |
0.709 | -0.099 | 4 | 0.777 |
JAK2 |
0.709 | -0.088 | 1 | 0.707 |
ROS1 |
0.708 | -0.103 | 3 | 0.643 |
NEK10_TYR |
0.707 | -0.011 | 1 | 0.619 |
TYRO3 |
0.707 | -0.130 | 3 | 0.680 |
YES1 |
0.707 | -0.085 | -1 | 0.804 |
TNK1 |
0.706 | 0.012 | 3 | 0.674 |
EPHA4 |
0.705 | -0.050 | 2 | 0.731 |
TYK2 |
0.704 | -0.209 | 1 | 0.699 |
LCK |
0.704 | -0.045 | -1 | 0.781 |
SRMS |
0.703 | -0.096 | 1 | 0.711 |
ITK |
0.703 | -0.083 | -1 | 0.746 |
JAK3 |
0.702 | -0.143 | 1 | 0.687 |
DDR2 |
0.701 | 0.035 | 3 | 0.589 |
FER |
0.701 | -0.170 | 1 | 0.733 |
MET |
0.701 | -0.062 | 3 | 0.683 |
CK1G3 |
0.701 | -0.059 | -3 | 0.337 |
STLK3 |
0.701 | -0.188 | 1 | 0.647 |
INSRR |
0.700 | -0.151 | 3 | 0.606 |
JAK1 |
0.700 | -0.057 | 1 | 0.658 |
KDR |
0.700 | -0.096 | 3 | 0.629 |
FGFR2 |
0.700 | -0.122 | 3 | 0.662 |
BLK |
0.699 | -0.059 | -1 | 0.775 |
TNNI3K_TYR |
0.699 | -0.040 | 1 | 0.701 |
KIT |
0.699 | -0.125 | 3 | 0.677 |
FYN |
0.699 | -0.041 | -1 | 0.767 |
HCK |
0.699 | -0.136 | -1 | 0.776 |
MERTK |
0.699 | -0.097 | 3 | 0.666 |
EPHB3 |
0.698 | -0.106 | -1 | 0.749 |
EPHB1 |
0.698 | -0.137 | 1 | 0.706 |
BMX |
0.698 | -0.069 | -1 | 0.684 |
EPHB2 |
0.697 | -0.105 | -1 | 0.739 |
AXL |
0.696 | -0.130 | 3 | 0.655 |
YANK2 |
0.695 | -0.075 | 2 | 0.387 |
PTK2B |
0.694 | -0.028 | -1 | 0.730 |
TEK |
0.693 | -0.131 | 3 | 0.601 |
FGFR1 |
0.692 | -0.149 | 3 | 0.632 |
FLT1 |
0.692 | -0.130 | -1 | 0.746 |
CK1G2 |
0.692 | -0.043 | -3 | 0.411 |
PDGFRB |
0.691 | -0.214 | 3 | 0.678 |
EPHA7 |
0.691 | -0.104 | 2 | 0.716 |
WEE1_TYR |
0.691 | -0.120 | -1 | 0.712 |
FGFR3 |
0.690 | -0.134 | 3 | 0.627 |
FLT3 |
0.690 | -0.206 | 3 | 0.673 |
EPHA3 |
0.689 | -0.128 | 2 | 0.690 |
PTK6 |
0.688 | -0.182 | -1 | 0.699 |
TEC |
0.688 | -0.153 | -1 | 0.686 |
SYK |
0.687 | -0.026 | -1 | 0.701 |
EPHA1 |
0.687 | -0.119 | 3 | 0.655 |
PTK2 |
0.687 | -0.026 | -1 | 0.708 |
LTK |
0.687 | -0.156 | 3 | 0.618 |
ALK |
0.686 | -0.167 | 3 | 0.584 |
BTK |
0.685 | -0.236 | -1 | 0.722 |
PDGFRA |
0.685 | -0.227 | 3 | 0.678 |
SRC |
0.684 | -0.111 | -1 | 0.764 |
ERBB2 |
0.684 | -0.191 | 1 | 0.664 |
MATK |
0.684 | -0.115 | -1 | 0.681 |
CSK |
0.683 | -0.124 | 2 | 0.719 |
FRK |
0.683 | -0.152 | -1 | 0.770 |
EPHA5 |
0.683 | -0.116 | 2 | 0.705 |
NTRK1 |
0.683 | -0.231 | -1 | 0.758 |
LYN |
0.683 | -0.155 | 3 | 0.595 |
EPHA8 |
0.683 | -0.112 | -1 | 0.734 |
NTRK3 |
0.682 | -0.152 | -1 | 0.726 |
INSR |
0.680 | -0.204 | 3 | 0.593 |
ZAP70 |
0.680 | 0.015 | -1 | 0.649 |
EGFR |
0.679 | -0.128 | 1 | 0.586 |
FGFR4 |
0.678 | -0.125 | -1 | 0.704 |
FLT4 |
0.678 | -0.225 | 3 | 0.624 |
NTRK2 |
0.674 | -0.277 | 3 | 0.621 |
EPHA2 |
0.673 | -0.115 | -1 | 0.696 |
ERBB4 |
0.670 | -0.103 | 1 | 0.596 |
IGF1R |
0.665 | -0.194 | 3 | 0.532 |
MUSK |
0.662 | -0.177 | 1 | 0.573 |
FES |
0.652 | -0.190 | -1 | 0.665 |