Motif 191 (n=209)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A096LP49 | CCDC187 | S1027 | ochoa | Coiled-coil domain-containing protein 187 | None |
| A6NEL2 | SOWAHB | S268 | ochoa | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | None |
| A6NHQ4 | EPOP | S179 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
| A7E2V4 | ZSWIM8 | S1058 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| B7Z1M9 | C2CD4D | S128 | ochoa | C2 calcium-dependent domain-containing protein 4D | None |
| B8ZZF3 | None | S342 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256|ARBA:ARBA00057523}. |
| H3BNR1 | BORCS8-MEF2B | S211 | ochoa | BORCS8-MEF2B readthrough | None |
| O00204 | SULT2B1 | S338 | ochoa | Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}. |
| O00257 | CBX4 | S467 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O00512 | BCL9 | S288 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14559 | ARHGAP33 | S780 | ochoa | Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) | May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}. |
| O14647 | CHD2 | S1799 | ochoa | Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.-) (ATP-dependent helicase CHD2) | ATP-dependent chromatin-remodeling factor that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}. |
| O14686 | KMT2D | S1872 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S2733 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15018 | PDZD2 | S1280 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15027 | SEC16A | S1079 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15389 | SIGLEC5 | S490 | ochoa | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| O43426 | SYNJ1 | S1295 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43432 | EIF4G3 | S1157 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43521 | BCL2L11 | S87 | psp | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269|PubMed:11997495, ECO:0000269|PubMed:15486195, ECO:0000269|PubMed:15661735, ECO:0000269|PubMed:9430630}. |
| O60240 | PLIN1 | S497 | ochoa|psp | Perilipin-1 (Lipid droplet-associated protein) | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
| O60307 | MAST3 | S57 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60336 | MAPKBP1 | S1198 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60336 | MAPKBP1 | S1253 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O60346 | PHLPP1 | S345 | psp | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341). Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity). {ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}. |
| O60503 | ADCY9 | S1269 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60716 | CTNND1 | S268 | ochoa|psp | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O94806 | PRKD3 | S37 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94806 | PRKD3 | S41 | ochoa | Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) | Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. |
| O94916 | NFAT5 | S155 | ochoa|psp | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95208 | EPN2 | S511 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| O95359 | TACC2 | S1283 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95402 | MED26 | S334 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| O95503 | CBX6 | S272 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95684 | CEP43 | S166 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| O95997 | PTTG1 | S181 | ochoa | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| P08151 | GLI1 | S1071 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P0C7T5 | ATXN1L | S203 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P11171 | EPB41 | S152 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12694 | BCKDHA | S47 | ochoa | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:7883996, ECO:0000269|PubMed:9582350}. |
| P16989 | YBX3 | S318 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17483 | HOXB4 | S115 | ochoa | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P17600 | SYN1 | S520 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18583 | SON | S998 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P22681 | CBL | S553 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23769 | GATA2 | S192 | ochoa|psp | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P25100 | ADRA1D | S492 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P27708 | CAD | S1859 | ochoa|psp | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P27987 | ITPKB | S43 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P30530 | AXL | S851 | ochoa | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}. |
| P42684 | ABL2 | S997 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P43405 | SYK | S316 | ochoa | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
| P46379 | BAG6 | S123 | ochoa | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}. |
| P46937 | YAP1 | S163 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P46937 | YAP1 | S227 | psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P49321 | NASP | S384 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P51608 | MECP2 | S396 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
| P53804 | TTC3 | S1816 | ochoa | E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950, ECO:0000269|PubMed:24695496, ECO:0000269|PubMed:30203323, ECO:0000269|PubMed:30696809}. |
| P54259 | ATN1 | S188 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P55884 | EIF3B | S95 | ochoa | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P98174 | FGD1 | S249 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q02080 | MEF2B | S194 | ochoa | Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription. |
| Q03188 | CENPC | S384 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q05397 | PTK2 | S732 | psp | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q07157 | TJP1 | S404 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S978 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07912 | TNK2 | S855 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q10586 | DBP | S161 | ochoa | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (Tax-responsive enhancer element-binding protein 302) (TaxREB302) | This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
| Q12778 | FOXO1 | S153 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12948 | FOXC1 | S269 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13094 | LCP2 | S207 | ochoa|psp | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13094 | LCP2 | S297 | ochoa | Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}. |
| Q13112 | CHAF1B | S458 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13263 | TRIM28 | S437 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13428 | TCOF1 | S328 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | S856 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13470 | TNK1 | S582 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13495 | MAMLD1 | S465 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13573 | SNW1 | S234 | ochoa | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| Q13586 | STIM1 | S618 | ochoa|psp | Stromal interaction molecule 1 | Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269|PubMed:15866891, ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16208375, ECO:0000269|PubMed:16537481, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:18854159, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:24069340, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25326555, ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068}. |
| Q13905 | RAPGEF1 | S463 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q13976 | PRKG1 | S65 | psp | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q14160 | SCRIB | S1559 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14653 | IRF3 | S175 | ochoa|psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14934 | NFATC4 | S274 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981). Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:18347059, PubMed:18668201, PubMed:7749981). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) (PubMed:25663301). Plays a role in adipocyte differentiation (PubMed:11997522). May be involved in myoblast differentiation into myotubes (PubMed:17213202). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription (PubMed:11514544). Binds to PPARG gene promoter and regulates its activity (PubMed:11997522). Binds to PPARG and REG3G gene promoters (By similarity). {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}. |
| Q14978 | NOLC1 | S303 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14CS0 | UBXN2B | S66 | ochoa | UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) | Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}. |
| Q15345 | LRRC41 | S369 | ochoa | Leucine-rich repeat-containing protein 41 (Protein Muf1) | Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269|PubMed:15601820}. |
| Q15751 | HERC1 | S2720 | ochoa | Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}. |
| Q15772 | SPEG | S435 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15772 | SPEG | S559 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16254 | E2F4 | S220 | ochoa | Transcription factor E2F4 (E2F-4) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}. |
| Q16849 | PTPRN | S303 | ochoa | Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)] | Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). {ECO:0000250|UniProtKB:Q60673, ECO:0000269|PubMed:24843546}.; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. {ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}.; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068). {ECO:0000269|PubMed:15596545, ECO:0000269|PubMed:16622421, ECO:0000269|PubMed:18178618, ECO:0000269|PubMed:18824546, ECO:0000269|PubMed:20886068}. |
| Q2M3G4 | SHROOM1 | S188 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q3T8J9 | GON4L | S1571 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q53ET0 | CRTC2 | S516 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5JRA6 | MIA3 | S1882 | ochoa | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}. |
| Q5SV97 | PERM1 | S166 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5T035 | FAM120A2P | Y42 | ochoa | Putative uncharacterized protein FAM120A2P (FAM120A2P pseudogene) | None |
| Q5T5Y3 | CAMSAP1 | S1140 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VT52 | RPRD2 | S1213 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUB5 | FAM171A1 | S644 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
| Q63HR2 | TNS2 | S845 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q66K74 | MAP1S | S592 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q66K74 | MAP1S | S610 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68CZ1 | RPGRIP1L | S999 | ochoa | Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity). {ECO:0000250|UniProtKB:Q8CG73, ECO:0000269|PubMed:19464661}. |
| Q68EM7 | ARHGAP17 | S599 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q69YQ0 | SPECC1L | S921 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6IBW4 | NCAPH2 | S325 | ochoa | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}. |
| Q6ICG6 | KIAA0930 | S289 | ochoa | Uncharacterized protein KIAA0930 | None |
| Q6P1L5 | FAM117B | S388 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6PJG9 | LRFN4 | S585 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
| Q6PKG0 | LARP1 | S323 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UXY1 | BAIAP2L2 | S481 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6WCQ1 | MPRIP | S372 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6YN16 | HSDL2 | S287 | ochoa | Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1) | Has apparently no steroid dehydrogenase activity (PubMed:19703561). Controls bile acid (BA) and lipid metabolism in response to nutritional cues (PubMed:38820148). {ECO:0000269|PubMed:19703561, ECO:0000269|PubMed:38820148}. |
| Q711Q0 | CEFIP | S1248 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q7Z2Z1 | TICRR | S1352 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z591 | AKNA | S1387 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5R6 | APBB1IP | S526 | ochoa | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) | Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Q7Z6B7 | SRGAP1 | S865 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z7F0 | KHDC4 | S40 | ochoa | KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4) | RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). {ECO:0000269|PubMed:19641227, ECO:0000269|PubMed:23144703}. |
| Q86UK7 | ZNF598 | S479 | ochoa | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32099016, PubMed:32579943, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32099016, PubMed:32579943, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:28065601, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:28685749, ECO:0000269|PubMed:29719242, ECO:0000269|PubMed:30293783, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:33581075, ECO:0000269|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269|PubMed:29719242}. |
| Q86V48 | LUZP1 | S903 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VM9 | ZC3H18 | S862 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IWX8 | CHERP | S705 | ochoa | Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6) | Involved in calcium homeostasis, growth and proliferation. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674}. |
| Q8IY67 | RAVER1 | S474 | ochoa | Ribonucleoprotein PTB-binding 1 (Protein raver-1) | Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}. |
| Q8IYB3 | SRRM1 | S638 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S725 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZW8 | TNS4 | S360 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N3F8 | MICALL1 | S588 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3V7 | SYNPO | S590 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N4C8 | MINK1 | S674 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4S9 | MARVELD2 | S64 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8N5J2 | MINDY1 | S95 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A) | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}. |
| Q8N960 | CEP120 | S402 | ochoa | Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000250|UniProtKB:Q7TSG1, ECO:0000269|PubMed:27185865}. |
| Q8NBZ0 | INO80E | S108 | ochoa | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
| Q8NC74 | RBBP8NL | S262 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NC96 | NECAP1 | S207 | ochoa | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | Involved in endocytosis. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S1893 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFA2 | NOXO1 | S336 | ochoa | NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}. |
| Q8NFH8 | REPS2 | S241 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8NFH8 | REPS2 | S489 | ochoa | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:10393179, PubMed:12771942, PubMed:9422736). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}. |
| Q8TBZ3 | WDR20 | S445 | ochoa | WD repeat-containing protein 20 (Protein DMR) | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). {ECO:0000269|PubMed:20147737, ECO:0000269|PubMed:27373336, ECO:0000269|PubMed:30466959}. |
| Q8WV28 | BLNK | S229 | ochoa | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}. |
| Q8WVT3 | TRAPPC12 | S111 | ochoa | Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis) | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224, ECO:0000269|PubMed:28777934}. |
| Q8WWI1 | LMO7 | S342 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXH0 | SYNE2 | S6785 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q8WYP5 | AHCTF1 | S1232 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92558 | WASF1 | S489 | ochoa | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
| Q92574 | TSC1 | S598 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92610 | ZNF592 | S689 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92888 | ARHGEF1 | S786 | ochoa | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed:9641915, PubMed:9641916). Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed:30521495, PubMed:8810315, PubMed:9641915, PubMed:9641916). Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed:9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed:9641916). Mediates angiotensin-2-induced RhoA activation (PubMed:20098430). In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:Q61210, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:30521495, ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9641915, ECO:0000269|PubMed:9641916}. |
| Q92917 | GPKOW | S27 | ochoa|psp | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q969T9 | WBP2 | Y192 | psp | WW domain-binding protein 2 (WBP-2) | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). {ECO:0000250|UniProtKB:P97765, ECO:0000269|PubMed:16772533}. |
| Q96C12 | ARMC5 | S510 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96I24 | FUBP3 | S457 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96JM3 | CHAMP1 | S196 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S331 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KG9 | SCYL1 | S747 | ochoa | N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) | Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}. |
| Q96MH2 | HEXIM2 | S39 | ochoa|psp | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}. |
| Q96NB3 | ZNF830 | S223 | ochoa | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). {ECO:0000250|UniProtKB:Q8R1N0, ECO:0000305|PubMed:25599396}. |
| Q96PK6 | RBM14 | S225 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96PN7 | TRERF1 | S725 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96RT1 | ERBIN | S984 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96RU3 | FNBP1 | S359 | ochoa | Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) | May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}. |
| Q96ST8 | CEP89 | S50 | ochoa | Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123) | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
| Q99618 | CDCA3 | S94 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99640 | PKMYT1 | S426 | psp | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}. |
| Q99700 | ATXN2 | S616 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BRD0 | BUD13 | S258 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BUL9 | RPP25 | S172 | ochoa | Ribonuclease P protein subunit p25 (RNase P protein subunit p25) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:16723659, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}. |
| Q9BWE0 | REPIN1 | S339 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
| Q9BXK5 | BCL2L13 | S444 | ochoa | Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) | May promote the activation of caspase-3 and apoptosis. |
| Q9BYV8 | CEP41 | S288 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
| Q9BYV9 | BACH2 | S520 | psp | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9C073 | FAM117A | S425 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0B5 | ZDHHC5 | S590 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | S379 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0D5 | TANC1 | S1513 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZP1 | NRSN2 | S181 | ochoa | Neurensin-2 | May play a role in maintenance and/or transport of vesicles. |
| Q9H063 | MAF1 | S70 | ochoa | Repressor of RNA polymerase III transcription MAF1 homolog | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}. |
| Q9H4M7 | PLEKHA4 | S274 | ochoa | Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) | Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}. |
| Q9H6S0 | YTHDC2 | S1279 | ochoa | 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2) | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}. |
| Q9H6Z4 | RANBP3 | S96 | ochoa | Ran-binding protein 3 (RanBP3) | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}. |
| Q9H987 | SYNPO2L | S180 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HCH5 | SYTL2 | S398 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9NQC3 | RTN4 | S107 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NQC3 | RTN4 | S181 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NR48 | ASH1L | S575 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NW07 | ZNF358 | S545 | ochoa | Zinc finger protein 358 | May be involved in transcriptional regulation. |
| Q9NZB2 | FAM120A | Y393 | ochoa | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9P219 | CCDC88C | S1740 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P266 | JCAD | S911 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UGK3 | STAP2 | S293 | ochoa | Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate) | Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}. |
| Q9UKS6 | PACSIN3 | S354 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| Q9UKW4 | VAV3 | S604 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9UPN7 | PPP6R1 | S770 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Q9UQ35 | SRRM2 | S1198 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S2459 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQQ2 | SH2B3 | S121 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y4B5 | MTCL1 | S87 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | S1234 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y6I3 | EPN1 | S486 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6J9 | TAF6L | S505 | ochoa | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) (PCAF-associated factor 65-alpha) (PAF65-alpha) | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release (By similarity). {ECO:0000250|UniProtKB:Q8R2K4, ECO:0000305|PubMed:9674419}. |
| Q9Y6K9 | IKBKG | S387 | ochoa|psp | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
| Q9UJY4 | GGA2 | S183 | Sugiyama | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| P16930 | FAH | S165 | Sugiyama | Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) | None |
| Q96RD6 | PANX2 | S514 | SIGNOR | Pannexin-2 | Ion channel with a slight anion preference (PubMed:36973289). Also able to release ATP (PubMed:36869038). Plays a role in regulating neurogenesis and apoptosis in keratinocytes (By similarity). {ECO:0000250|UniProtKB:Q6IMP4, ECO:0000269|PubMed:36869038, ECO:0000269|PubMed:36973289}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9607240 | FLT3 Signaling | 0.000060 | 4.223 |
| R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000365 | 3.438 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.000363 | 3.441 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.002220 | 2.654 |
| R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.003169 | 2.499 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.003169 | 2.499 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.003144 | 2.502 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.002157 | 2.666 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.001846 | 2.734 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.002744 | 2.562 |
| R-HSA-162582 | Signal Transduction | 0.002647 | 2.577 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.004275 | 2.369 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.004050 | 2.393 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.005533 | 2.257 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.005533 | 2.257 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005533 | 2.257 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.005191 | 2.285 |
| R-HSA-2172127 | DAP12 interactions | 0.005946 | 2.226 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.007238 | 2.140 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 0.008493 | 2.071 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.008493 | 2.071 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.012013 | 1.920 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.012034 | 1.920 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.013974 | 1.855 |
| R-HSA-2424491 | DAP12 signaling | 0.013651 | 1.865 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.014710 | 1.832 |
| R-HSA-354192 | Integrin signaling | 0.016851 | 1.773 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.017064 | 1.768 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.040161 | 1.396 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.040161 | 1.396 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.053188 | 1.274 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.053188 | 1.274 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.053188 | 1.274 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.053188 | 1.274 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.053188 | 1.274 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.053188 | 1.274 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.053188 | 1.274 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.053188 | 1.274 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.053188 | 1.274 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.053188 | 1.274 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.053188 | 1.274 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.066039 | 1.180 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.066039 | 1.180 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.066039 | 1.180 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.078717 | 1.104 |
| R-HSA-74713 | IRS activation | 0.091223 | 1.040 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.091223 | 1.040 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.020611 | 1.686 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.020611 | 1.686 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.020611 | 1.686 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.103560 | 0.985 |
| R-HSA-9907570 | Loss-of-function mutations in DLD cause MSUD3/DLDD | 0.103560 | 0.985 |
| R-HSA-9865113 | Loss-of-function mutations in DBT cause MSUD2 | 0.103560 | 0.985 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.115730 | 0.937 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.115730 | 0.937 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.115730 | 0.937 |
| R-HSA-9912529 | H139Hfs13* PPM1K causes a mild variant of MSUD | 0.115730 | 0.937 |
| R-HSA-9865125 | Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD | 0.115730 | 0.937 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.028303 | 1.548 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.031085 | 1.507 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.127736 | 0.894 |
| R-HSA-112412 | SOS-mediated signalling | 0.127736 | 0.894 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.036955 | 1.432 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.162788 | 0.788 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.056792 | 1.246 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.071633 | 1.145 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.196438 | 0.707 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.196438 | 0.707 |
| R-HSA-9865114 | Maple Syrup Urine Disease | 0.196438 | 0.707 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 0.207353 | 0.683 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.083490 | 1.078 |
| R-HSA-9859138 | BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV | 0.218120 | 0.661 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 0.228742 | 0.641 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.228742 | 0.641 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.239220 | 0.621 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.079392 | 1.100 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.289522 | 0.538 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.308702 | 0.510 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.308702 | 0.510 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.028234 | 1.549 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.354429 | 0.450 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.253183 | 0.597 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.253183 | 0.597 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.268293 | 0.571 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.283399 | 0.548 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.303494 | 0.518 |
| R-HSA-380287 | Centrosome maturation | 0.313506 | 0.504 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.367876 | 0.434 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.367876 | 0.434 |
| R-HSA-182971 | EGFR downregulation | 0.091701 | 1.038 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.049436 | 1.306 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.087566 | 1.058 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.126655 | 0.897 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.126655 | 0.897 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.049833 | 1.302 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.047977 | 1.319 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.126655 | 0.897 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.162788 | 0.788 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.228742 | 0.641 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.308702 | 0.510 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.162788 | 0.788 |
| R-HSA-198203 | PI3K/AKT activation | 0.162788 | 0.788 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.174158 | 0.759 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.036870 | 1.433 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.191433 | 0.718 |
| R-HSA-191650 | Regulation of gap junction activity | 0.078717 | 1.104 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.207353 | 0.683 |
| R-HSA-418457 | cGMP effects | 0.218120 | 0.661 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.020611 | 1.686 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.053272 | 1.274 |
| R-HSA-72172 | mRNA Splicing | 0.035543 | 1.449 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.091223 | 1.040 |
| R-HSA-8875878 | MET promotes cell motility | 0.024404 | 1.613 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.183445 | 0.736 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.021714 | 1.663 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.249556 | 0.603 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.033131 | 1.480 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.228742 | 0.641 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.022385 | 1.650 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.022385 | 1.650 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.174158 | 0.759 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.238096 | 0.623 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.238096 | 0.623 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.238096 | 0.623 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.238096 | 0.623 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.210143 | 0.677 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.218120 | 0.661 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.308702 | 0.510 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.169122 | 0.772 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.169122 | 0.772 |
| R-HSA-9664407 | Parasite infection | 0.169122 | 0.772 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.040038 | 1.398 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.135685 | 0.867 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.213077 | 0.671 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.167780 | 0.775 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.181191 | 0.742 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.380407 | 0.420 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.117757 | 0.929 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.066039 | 1.180 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.066039 | 1.180 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.078717 | 1.104 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.078717 | 1.104 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.103560 | 0.985 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.115730 | 0.937 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.139579 | 0.855 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.151263 | 0.820 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.196438 | 0.707 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.228742 | 0.641 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.269811 | 0.569 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.269811 | 0.569 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.269811 | 0.569 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.269811 | 0.569 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.336512 | 0.473 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.171763 | 0.765 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.354429 | 0.450 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.271538 | 0.566 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.240905 | 0.618 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 0.091223 | 1.040 |
| R-HSA-74749 | Signal attenuation | 0.162788 | 0.788 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.279733 | 0.553 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.289522 | 0.538 |
| R-HSA-9620244 | Long-term potentiation | 0.345531 | 0.462 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.380407 | 0.420 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.035085 | 1.455 |
| R-HSA-177929 | Signaling by EGFR | 0.218062 | 0.661 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.289522 | 0.538 |
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.139579 | 0.855 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.162788 | 0.788 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.162788 | 0.788 |
| R-HSA-9930044 | Nuclear RNA decay | 0.100138 | 0.999 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.031228 | 1.505 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.259752 | 0.585 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.318099 | 0.497 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.354429 | 0.450 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.308504 | 0.511 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.358099 | 0.446 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.293456 | 0.532 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.151263 | 0.820 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.085870 | 1.066 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.033131 | 1.480 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.278366 | 0.555 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.371865 | 0.430 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.380407 | 0.420 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.067073 | 1.173 |
| R-HSA-194138 | Signaling by VEGF | 0.044369 | 1.353 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.025628 | 1.591 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.174158 | 0.759 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.196438 | 0.707 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.228742 | 0.641 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.279733 | 0.553 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.092318 | 1.035 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.299177 | 0.524 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.358099 | 0.446 |
| R-HSA-68877 | Mitotic Prometaphase | 0.329404 | 0.482 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.216043 | 0.665 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.336512 | 0.473 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.238096 | 0.623 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.318501 | 0.497 |
| R-HSA-9843745 | Adipogenesis | 0.325584 | 0.487 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.163883 | 0.785 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.380407 | 0.420 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.228742 | 0.641 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.239220 | 0.621 |
| R-HSA-2028269 | Signaling by Hippo | 0.036955 | 1.432 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.185374 | 0.732 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.249556 | 0.603 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.269811 | 0.569 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.140413 | 0.853 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.279733 | 0.553 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.020434 | 1.690 |
| R-HSA-6806834 | Signaling by MET | 0.033537 | 1.474 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.078717 | 1.104 |
| R-HSA-112307 | Transmission across Electrical Synapses | 0.078717 | 1.104 |
| R-HSA-112303 | Electric Transmission Across Gap Junctions | 0.078717 | 1.104 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.025628 | 1.591 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.031085 | 1.507 |
| R-HSA-390696 | Adrenoceptors | 0.139579 | 0.855 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.139579 | 0.855 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.151263 | 0.820 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.196438 | 0.707 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.196438 | 0.707 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.218120 | 0.661 |
| R-HSA-163615 | PKA activation | 0.269811 | 0.569 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.308702 | 0.510 |
| R-HSA-429947 | Deadenylation of mRNA | 0.336512 | 0.473 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.371865 | 0.430 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.380407 | 0.420 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.380407 | 0.420 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.288430 | 0.540 |
| R-HSA-9658195 | Leishmania infection | 0.231300 | 0.636 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.231300 | 0.636 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.288430 | 0.540 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.380407 | 0.420 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.062764 | 1.202 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.028759 | 1.541 |
| R-HSA-212436 | Generic Transcription Pathway | 0.315507 | 0.501 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.239220 | 0.621 |
| R-HSA-9664420 | Killing mechanisms | 0.239220 | 0.621 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.249556 | 0.603 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.268293 | 0.571 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.317410 | 0.498 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.117612 | 0.930 |
| R-HSA-75153 | Apoptotic execution phase | 0.038619 | 1.413 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.091223 | 1.040 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.103560 | 0.985 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.174158 | 0.759 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.100138 | 0.999 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.021667 | 1.664 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.308702 | 0.510 |
| R-HSA-156584 | Cytosolic sulfonation of small molecules | 0.193259 | 0.714 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.363207 | 0.440 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.313506 | 0.504 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.249556 | 0.603 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.248150 | 0.605 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.362995 | 0.440 |
| R-HSA-69275 | G2/M Transition | 0.307935 | 0.512 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.314056 | 0.503 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.262557 | 0.581 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.373758 | 0.427 |
| R-HSA-199991 | Membrane Trafficking | 0.042619 | 1.370 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.103560 | 0.985 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.100138 | 0.999 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.259752 | 0.585 |
| R-HSA-8963684 | Tyrosine catabolism | 0.269811 | 0.569 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.033966 | 1.469 |
| R-HSA-5617833 | Cilium Assembly | 0.320188 | 0.495 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.074197 | 1.130 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.060325 | 1.220 |
| R-HSA-170968 | Frs2-mediated activation | 0.207353 | 0.683 |
| R-HSA-186712 | Regulation of beta-cell development | 0.065029 | 1.187 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.207353 | 0.683 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.165056 | 0.782 |
| R-HSA-392517 | Rap1 signalling | 0.279733 | 0.553 |
| R-HSA-8854214 | TBC/RABGAPs | 0.154514 | 0.811 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.299177 | 0.524 |
| R-HSA-525793 | Myogenesis | 0.354429 | 0.450 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.054366 | 1.265 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.113173 | 0.946 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.095654 | 1.019 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.299177 | 0.524 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.299177 | 0.524 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.070589 | 1.151 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.025878 | 1.587 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.299177 | 0.524 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.186025 | 0.730 |
| R-HSA-8848021 | Signaling by PTK6 | 0.253183 | 0.597 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.253183 | 0.597 |
| R-HSA-109581 | Apoptosis | 0.233084 | 0.632 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.071633 | 1.145 |
| R-HSA-6807070 | PTEN Regulation | 0.166495 | 0.779 |
| R-HSA-2586552 | Signaling by Leptin | 0.162788 | 0.788 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.174158 | 0.759 |
| R-HSA-169893 | Prolonged ERK activation events | 0.239220 | 0.621 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.142624 | 0.846 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.139579 | 0.855 |
| R-HSA-9842663 | Signaling by LTK | 0.196438 | 0.707 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.218120 | 0.661 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.018306 | 1.737 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.218062 | 0.661 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.354429 | 0.450 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.125363 | 0.902 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.100138 | 0.999 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.266398 | 0.574 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.327368 | 0.485 |
| R-HSA-5357801 | Programmed Cell Death | 0.369447 | 0.432 |
| R-HSA-73887 | Death Receptor Signaling | 0.031929 | 1.496 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.023038 | 1.638 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.318099 | 0.497 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.327368 | 0.485 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.354429 | 0.450 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.223059 | 0.652 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.298777 | 0.525 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.184588 | 0.734 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.243121 | 0.614 |
| R-HSA-9758941 | Gastrulation | 0.196154 | 0.707 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.269811 | 0.569 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.222963 | 0.652 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.178566 | 0.748 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.123507 | 0.908 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.222963 | 0.652 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.259752 | 0.585 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.259752 | 0.585 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.327368 | 0.485 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.266398 | 0.574 |
| R-HSA-2559583 | Cellular Senescence | 0.289655 | 0.538 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.095893 | 1.018 |
| R-HSA-9830364 | Formation of the nephric duct | 0.345531 | 0.462 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.154514 | 0.811 |
| R-HSA-195721 | Signaling by WNT | 0.269660 | 0.569 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.207353 | 0.683 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.064066 | 1.193 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.064066 | 1.193 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.075520 | 1.122 |
| R-HSA-9830369 | Kidney development | 0.273330 | 0.563 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.345531 | 0.462 |
| R-HSA-9909396 | Circadian clock | 0.329299 | 0.482 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.327368 | 0.485 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.323488 | 0.490 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.336512 | 0.473 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.382431 | 0.417 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.382431 | 0.417 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.388833 | 0.410 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.388833 | 0.410 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.388833 | 0.410 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.388833 | 0.410 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.392139 | 0.407 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.396842 | 0.401 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.397144 | 0.401 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.397144 | 0.401 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.397144 | 0.401 |
| R-HSA-186763 | Downstream signal transduction | 0.397144 | 0.401 |
| R-HSA-1538133 | G0 and Early G1 | 0.405344 | 0.392 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.405344 | 0.392 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.406363 | 0.391 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.410227 | 0.387 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.413432 | 0.384 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.413432 | 0.384 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.413432 | 0.384 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.413432 | 0.384 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.417635 | 0.379 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.420509 | 0.376 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.421410 | 0.375 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.421410 | 0.375 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.421410 | 0.375 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.429281 | 0.367 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.429281 | 0.367 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.429281 | 0.367 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.429281 | 0.367 |
| R-HSA-187687 | Signalling to ERKs | 0.437045 | 0.359 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.439212 | 0.357 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.439717 | 0.357 |
| R-HSA-163560 | Triglyceride catabolism | 0.444704 | 0.352 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.444704 | 0.352 |
| R-HSA-111933 | Calmodulin induced events | 0.444704 | 0.352 |
| R-HSA-8853659 | RET signaling | 0.444704 | 0.352 |
| R-HSA-111997 | CaM pathway | 0.444704 | 0.352 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.444704 | 0.352 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.448272 | 0.348 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.452259 | 0.345 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.452259 | 0.345 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.452259 | 0.345 |
| R-HSA-8963691 | Phenylalanine and tyrosine metabolism | 0.452259 | 0.345 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.452259 | 0.345 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.453428 | 0.343 |
| R-HSA-1483255 | PI Metabolism | 0.457361 | 0.340 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.457724 | 0.339 |
| R-HSA-74160 | Gene expression (Transcription) | 0.464271 | 0.333 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.467064 | 0.331 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.467064 | 0.331 |
| R-HSA-9833110 | RSV-host interactions | 0.470831 | 0.327 |
| R-HSA-68886 | M Phase | 0.473172 | 0.325 |
| R-HSA-202433 | Generation of second messenger molecules | 0.474316 | 0.324 |
| R-HSA-5260271 | Diseases of Immune System | 0.474316 | 0.324 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.474316 | 0.324 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.474316 | 0.324 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.474316 | 0.324 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.475277 | 0.323 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.475277 | 0.323 |
| R-HSA-418346 | Platelet homeostasis | 0.479700 | 0.319 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.481470 | 0.317 |
| R-HSA-9694548 | Maturation of spike protein | 0.481470 | 0.317 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.488527 | 0.311 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.488527 | 0.311 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.488527 | 0.311 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.488527 | 0.311 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.488527 | 0.311 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.488527 | 0.311 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.492832 | 0.307 |
| R-HSA-991365 | Activation of GABAB receptors | 0.495489 | 0.305 |
| R-HSA-977444 | GABA B receptor activation | 0.495489 | 0.305 |
| R-HSA-165159 | MTOR signalling | 0.495489 | 0.305 |
| R-HSA-111996 | Ca-dependent events | 0.495489 | 0.305 |
| R-HSA-202403 | TCR signaling | 0.497162 | 0.304 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.497162 | 0.304 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.497162 | 0.304 |
| R-HSA-4839726 | Chromatin organization | 0.501828 | 0.299 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.502356 | 0.299 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.502356 | 0.299 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.504184 | 0.297 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.505753 | 0.296 |
| R-HSA-373752 | Netrin-1 signaling | 0.509130 | 0.293 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.509130 | 0.293 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.509130 | 0.293 |
| R-HSA-69236 | G1 Phase | 0.509130 | 0.293 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.509130 | 0.293 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.510013 | 0.292 |
| R-HSA-774815 | Nucleosome assembly | 0.515812 | 0.288 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.515812 | 0.288 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.515812 | 0.288 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.515812 | 0.288 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.515812 | 0.288 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.515812 | 0.288 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.515812 | 0.288 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.515812 | 0.288 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.522404 | 0.282 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.522404 | 0.282 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.522404 | 0.282 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.522404 | 0.282 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.522404 | 0.282 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.522404 | 0.282 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.522404 | 0.282 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.522404 | 0.282 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.526811 | 0.278 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.528907 | 0.277 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.528907 | 0.277 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.528907 | 0.277 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.533726 | 0.273 |
| R-HSA-9634597 | GPER1 signaling | 0.535321 | 0.271 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.539154 | 0.268 |
| R-HSA-1640170 | Cell Cycle | 0.539810 | 0.268 |
| R-HSA-9766229 | Degradation of CDH1 | 0.541648 | 0.266 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.541648 | 0.266 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.543218 | 0.265 |
| R-HSA-109704 | PI3K Cascade | 0.547890 | 0.261 |
| R-HSA-9748787 | Azathioprine ADME | 0.547890 | 0.261 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.551273 | 0.259 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.554047 | 0.256 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.554047 | 0.256 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.559228 | 0.252 |
| R-HSA-72187 | mRNA 3'-end processing | 0.560120 | 0.252 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.560120 | 0.252 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.560120 | 0.252 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.564003 | 0.249 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.566111 | 0.247 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.566111 | 0.247 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.566111 | 0.247 |
| R-HSA-1221632 | Meiotic synapsis | 0.566111 | 0.247 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.566111 | 0.247 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.568825 | 0.245 |
| R-HSA-72649 | Translation initiation complex formation | 0.572021 | 0.243 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.574835 | 0.240 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.577851 | 0.238 |
| R-HSA-418597 | G alpha (z) signalling events | 0.577851 | 0.238 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.582488 | 0.235 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.582691 | 0.235 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.583602 | 0.234 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.583602 | 0.234 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.583602 | 0.234 |
| R-HSA-5578775 | Ion homeostasis | 0.583602 | 0.234 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.583602 | 0.234 |
| R-HSA-75893 | TNF signaling | 0.583602 | 0.234 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.583602 | 0.234 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.585746 | 0.232 |
| R-HSA-112399 | IRS-mediated signalling | 0.589275 | 0.230 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.589275 | 0.230 |
| R-HSA-5621480 | Dectin-2 family | 0.589275 | 0.230 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.590039 | 0.229 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.594870 | 0.226 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.594870 | 0.226 |
| R-HSA-8979227 | Triglyceride metabolism | 0.600390 | 0.222 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.600390 | 0.222 |
| R-HSA-1280218 | Adaptive Immune System | 0.600773 | 0.221 |
| R-HSA-977443 | GABA receptor activation | 0.605835 | 0.218 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.605835 | 0.218 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.605835 | 0.218 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.610758 | 0.214 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.611207 | 0.214 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.611207 | 0.214 |
| R-HSA-450294 | MAP kinase activation | 0.611207 | 0.214 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.611207 | 0.214 |
| R-HSA-112043 | PLC beta mediated events | 0.611207 | 0.214 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.616505 | 0.210 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.616505 | 0.210 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.616505 | 0.210 |
| R-HSA-9707616 | Heme signaling | 0.616505 | 0.210 |
| R-HSA-186797 | Signaling by PDGF | 0.616505 | 0.210 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.619228 | 0.208 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.622762 | 0.206 |
| R-HSA-8953854 | Metabolism of RNA | 0.625088 | 0.204 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.626887 | 0.203 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.626887 | 0.203 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.626887 | 0.203 |
| R-HSA-68882 | Mitotic Anaphase | 0.627002 | 0.203 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.628268 | 0.202 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.629839 | 0.201 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.631972 | 0.199 |
| R-HSA-112040 | G-protein mediated events | 0.641937 | 0.193 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.646819 | 0.189 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.656384 | 0.183 |
| R-HSA-448424 | Interleukin-17 signaling | 0.656384 | 0.183 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.656384 | 0.183 |
| R-HSA-449147 | Signaling by Interleukins | 0.659853 | 0.181 |
| R-HSA-112316 | Neuronal System | 0.660289 | 0.180 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.661069 | 0.180 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.661069 | 0.180 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.663218 | 0.178 |
| R-HSA-166520 | Signaling by NTRKs | 0.663218 | 0.178 |
| R-HSA-109582 | Hemostasis | 0.664850 | 0.177 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.665690 | 0.177 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.665690 | 0.177 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.669613 | 0.174 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.670249 | 0.174 |
| R-HSA-4086398 | Ca2+ pathway | 0.670249 | 0.174 |
| R-HSA-9679506 | SARS-CoV Infections | 0.674709 | 0.171 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.674746 | 0.171 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.674746 | 0.171 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.675909 | 0.170 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.679182 | 0.168 |
| R-HSA-5689603 | UCH proteinases | 0.683558 | 0.165 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.687875 | 0.162 |
| R-HSA-4086400 | PCP/CE pathway | 0.692132 | 0.160 |
| R-HSA-9659379 | Sensory processing of sound | 0.696332 | 0.157 |
| R-HSA-877300 | Interferon gamma signaling | 0.697184 | 0.157 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.700475 | 0.155 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.700475 | 0.155 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.700475 | 0.155 |
| R-HSA-9833482 | PKR-mediated signaling | 0.700475 | 0.155 |
| R-HSA-977225 | Amyloid fiber formation | 0.704562 | 0.152 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.708593 | 0.150 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.712569 | 0.147 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.716491 | 0.145 |
| R-HSA-9675108 | Nervous system development | 0.719753 | 0.143 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.720360 | 0.142 |
| R-HSA-1500620 | Meiosis | 0.720360 | 0.142 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.724177 | 0.140 |
| R-HSA-5688426 | Deubiquitination | 0.726590 | 0.139 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.727942 | 0.138 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.731655 | 0.136 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.733317 | 0.135 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.736277 | 0.133 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.738898 | 0.131 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.738898 | 0.131 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.738898 | 0.131 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.738931 | 0.131 |
| R-HSA-202424 | Downstream TCR signaling | 0.742495 | 0.129 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.742495 | 0.129 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.744075 | 0.128 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.752900 | 0.123 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.752900 | 0.123 |
| R-HSA-1266738 | Developmental Biology | 0.752910 | 0.123 |
| R-HSA-2029481 | FCGR activation | 0.756274 | 0.121 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.759602 | 0.119 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.762886 | 0.118 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.766124 | 0.116 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.769319 | 0.114 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.775578 | 0.110 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.775578 | 0.110 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.775578 | 0.110 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.775578 | 0.110 |
| R-HSA-190236 | Signaling by FGFR | 0.775578 | 0.110 |
| R-HSA-3214847 | HATs acetylate histones | 0.778644 | 0.109 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.782411 | 0.107 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.782536 | 0.106 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.784632 | 0.105 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.784651 | 0.105 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.784651 | 0.105 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.787594 | 0.104 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.787594 | 0.104 |
| R-HSA-422475 | Axon guidance | 0.787962 | 0.103 |
| R-HSA-9609690 | HCMV Early Events | 0.793318 | 0.101 |
| R-HSA-111885 | Opioid Signalling | 0.793359 | 0.101 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.801695 | 0.096 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.801717 | 0.096 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.804082 | 0.095 |
| R-HSA-913531 | Interferon Signaling | 0.804082 | 0.095 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.807100 | 0.093 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.807100 | 0.093 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.807100 | 0.093 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.807100 | 0.093 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.807100 | 0.093 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.809737 | 0.092 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.819932 | 0.086 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.824823 | 0.084 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.826882 | 0.083 |
| R-HSA-397014 | Muscle contraction | 0.826882 | 0.083 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.827219 | 0.082 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.827219 | 0.082 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.829582 | 0.081 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.831913 | 0.080 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.831913 | 0.080 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.838718 | 0.076 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.838718 | 0.076 |
| R-HSA-68875 | Mitotic Prophase | 0.840924 | 0.075 |
| R-HSA-8951664 | Neddylation | 0.842601 | 0.074 |
| R-HSA-73886 | Chromosome Maintenance | 0.843101 | 0.074 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.845248 | 0.073 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.845248 | 0.073 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.847365 | 0.072 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.849211 | 0.071 |
| R-HSA-69206 | G1/S Transition | 0.853547 | 0.069 |
| R-HSA-114608 | Platelet degranulation | 0.857529 | 0.067 |
| R-HSA-69481 | G2/M Checkpoints | 0.857529 | 0.067 |
| R-HSA-1474165 | Reproduction | 0.865172 | 0.063 |
| R-HSA-5576891 | Cardiac conduction | 0.867018 | 0.062 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.870229 | 0.060 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.870636 | 0.060 |
| R-HSA-157118 | Signaling by NOTCH | 0.871625 | 0.060 |
| R-HSA-163685 | Integration of energy metabolism | 0.877579 | 0.057 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.880910 | 0.055 |
| R-HSA-9609646 | HCMV Infection | 0.884852 | 0.053 |
| R-HSA-1632852 | Macroautophagy | 0.885738 | 0.053 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.891874 | 0.050 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.892173 | 0.050 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.894818 | 0.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.896440 | 0.047 |
| R-HSA-69242 | S Phase | 0.897682 | 0.047 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.900169 | 0.046 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.900469 | 0.046 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.903179 | 0.044 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.903179 | 0.044 |
| R-HSA-9609507 | Protein localization | 0.904507 | 0.044 |
| R-HSA-1989781 | PPARA activates gene expression | 0.907108 | 0.042 |
| R-HSA-9612973 | Autophagy | 0.908383 | 0.042 |
| R-HSA-9610379 | HCMV Late Events | 0.909639 | 0.041 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.909639 | 0.041 |
| R-HSA-1643685 | Disease | 0.909723 | 0.041 |
| R-HSA-168256 | Immune System | 0.916640 | 0.038 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.925533 | 0.034 |
| R-HSA-72306 | tRNA processing | 0.925533 | 0.034 |
| R-HSA-418555 | G alpha (s) signalling events | 0.926555 | 0.033 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.928559 | 0.032 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.928559 | 0.032 |
| R-HSA-1483257 | Phospholipid metabolism | 0.930175 | 0.031 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.930507 | 0.031 |
| R-HSA-5663205 | Infectious disease | 0.939556 | 0.027 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.941946 | 0.026 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.942725 | 0.026 |
| R-HSA-1500931 | Cell-Cell communication | 0.945010 | 0.025 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.948032 | 0.023 |
| R-HSA-428157 | Sphingolipid metabolism | 0.951509 | 0.022 |
| R-HSA-9824446 | Viral Infection Pathways | 0.955294 | 0.020 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.959502 | 0.018 |
| R-HSA-6798695 | Neutrophil degranulation | 0.960005 | 0.018 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.960671 | 0.017 |
| R-HSA-168249 | Innate Immune System | 0.961478 | 0.017 |
| R-HSA-418990 | Adherens junctions interactions | 0.962215 | 0.017 |
| R-HSA-9748784 | Drug ADME | 0.962215 | 0.017 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.963204 | 0.016 |
| R-HSA-73894 | DNA Repair | 0.966977 | 0.015 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.967562 | 0.014 |
| R-HSA-72312 | rRNA processing | 0.968885 | 0.014 |
| R-HSA-15869 | Metabolism of nucleotides | 0.970565 | 0.013 |
| R-HSA-8939211 | ESR-mediated signaling | 0.970971 | 0.013 |
| R-HSA-421270 | Cell-cell junction organization | 0.976101 | 0.011 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.977101 | 0.010 |
| R-HSA-416476 | G alpha (q) signalling events | 0.980052 | 0.009 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.981132 | 0.008 |
| R-HSA-446728 | Cell junction organization | 0.983583 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.985265 | 0.006 |
| R-HSA-72766 | Translation | 0.985653 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.993494 | 0.003 |
| R-HSA-211859 | Biological oxidations | 0.995475 | 0.002 |
| R-HSA-2262752 | Cellular responses to stress | 0.996075 | 0.002 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.996798 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.997332 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.997985 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.998635 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.999496 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 0.999796 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999993 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999995 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999999 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.869 | 0.388 | 1 | 0.874 |
HIPK4 |
0.863 | 0.398 | 1 | 0.857 |
SRPK1 |
0.861 | 0.340 | -3 | 0.843 |
RSK2 |
0.860 | 0.349 | -3 | 0.859 |
PIM3 |
0.860 | 0.314 | -3 | 0.893 |
NDR2 |
0.859 | 0.272 | -3 | 0.892 |
PRKD1 |
0.857 | 0.337 | -3 | 0.889 |
PRKD2 |
0.856 | 0.332 | -3 | 0.870 |
COT |
0.855 | 0.151 | 2 | 0.828 |
CLK2 |
0.855 | 0.401 | -3 | 0.845 |
SKMLCK |
0.853 | 0.351 | -2 | 0.910 |
AURC |
0.853 | 0.326 | -2 | 0.760 |
HIPK2 |
0.853 | 0.382 | 1 | 0.750 |
DYRK2 |
0.852 | 0.349 | 1 | 0.817 |
CDKL5 |
0.852 | 0.289 | -3 | 0.862 |
P90RSK |
0.852 | 0.308 | -3 | 0.854 |
PIM1 |
0.851 | 0.312 | -3 | 0.869 |
PKACB |
0.850 | 0.348 | -2 | 0.764 |
NDR1 |
0.849 | 0.238 | -3 | 0.887 |
SRPK2 |
0.849 | 0.293 | -3 | 0.783 |
CDKL1 |
0.849 | 0.275 | -3 | 0.860 |
MAPKAPK2 |
0.849 | 0.278 | -3 | 0.844 |
CLK4 |
0.849 | 0.365 | -3 | 0.845 |
HIPK1 |
0.848 | 0.391 | 1 | 0.832 |
ICK |
0.848 | 0.331 | -3 | 0.887 |
RSK3 |
0.848 | 0.279 | -3 | 0.845 |
CLK1 |
0.847 | 0.354 | -3 | 0.833 |
KIS |
0.846 | 0.232 | 1 | 0.802 |
CAMK1B |
0.846 | 0.245 | -3 | 0.879 |
NLK |
0.846 | 0.226 | 1 | 0.883 |
PKACG |
0.845 | 0.260 | -2 | 0.805 |
RSK4 |
0.845 | 0.324 | -3 | 0.845 |
CDC7 |
0.845 | 0.075 | 1 | 0.801 |
MOS |
0.845 | 0.167 | 1 | 0.844 |
MAPKAPK3 |
0.844 | 0.247 | -3 | 0.863 |
LATS2 |
0.843 | 0.180 | -5 | 0.728 |
PRKX |
0.843 | 0.325 | -3 | 0.809 |
ERK5 |
0.843 | 0.195 | 1 | 0.884 |
CAMLCK |
0.842 | 0.288 | -2 | 0.885 |
MSK1 |
0.840 | 0.309 | -3 | 0.838 |
DYRK4 |
0.840 | 0.325 | 1 | 0.756 |
MTOR |
0.840 | 0.048 | 1 | 0.801 |
P70S6KB |
0.839 | 0.240 | -3 | 0.859 |
WNK1 |
0.839 | 0.145 | -2 | 0.896 |
SRPK3 |
0.839 | 0.251 | -3 | 0.803 |
PKN3 |
0.838 | 0.165 | -3 | 0.868 |
DYRK1A |
0.838 | 0.333 | 1 | 0.826 |
DAPK2 |
0.837 | 0.275 | -3 | 0.878 |
NUAK2 |
0.837 | 0.163 | -3 | 0.892 |
PRKD3 |
0.837 | 0.266 | -3 | 0.833 |
CAMK2D |
0.837 | 0.173 | -3 | 0.870 |
PRPK |
0.837 | -0.059 | -1 | 0.870 |
PAK1 |
0.837 | 0.235 | -2 | 0.855 |
CDK7 |
0.837 | 0.221 | 1 | 0.787 |
HIPK3 |
0.837 | 0.350 | 1 | 0.820 |
AKT2 |
0.836 | 0.307 | -3 | 0.801 |
MSK2 |
0.836 | 0.244 | -3 | 0.832 |
CAMK2A |
0.835 | 0.218 | 2 | 0.789 |
PKG2 |
0.835 | 0.272 | -2 | 0.755 |
AURB |
0.835 | 0.267 | -2 | 0.756 |
DYRK3 |
0.835 | 0.356 | 1 | 0.829 |
TSSK1 |
0.835 | 0.211 | -3 | 0.907 |
MAK |
0.835 | 0.399 | -2 | 0.790 |
PKN2 |
0.834 | 0.157 | -3 | 0.876 |
IKKB |
0.834 | -0.042 | -2 | 0.714 |
NIK |
0.834 | 0.188 | -3 | 0.872 |
RAF1 |
0.834 | -0.016 | 1 | 0.807 |
AMPKA1 |
0.834 | 0.162 | -3 | 0.895 |
CDK18 |
0.834 | 0.246 | 1 | 0.738 |
DYRK1B |
0.834 | 0.313 | 1 | 0.781 |
PKACA |
0.834 | 0.311 | -2 | 0.723 |
GRK1 |
0.834 | 0.122 | -2 | 0.785 |
PKCD |
0.834 | 0.186 | 2 | 0.729 |
PAK6 |
0.833 | 0.258 | -2 | 0.793 |
PIM2 |
0.833 | 0.290 | -3 | 0.836 |
ATR |
0.833 | 0.036 | 1 | 0.790 |
LATS1 |
0.833 | 0.242 | -3 | 0.891 |
CDK19 |
0.833 | 0.207 | 1 | 0.744 |
JNK2 |
0.832 | 0.260 | 1 | 0.742 |
CDK8 |
0.832 | 0.186 | 1 | 0.771 |
AMPKA2 |
0.832 | 0.178 | -3 | 0.885 |
MNK2 |
0.832 | 0.209 | -2 | 0.848 |
TBK1 |
0.831 | -0.050 | 1 | 0.705 |
PAK3 |
0.831 | 0.195 | -2 | 0.847 |
SGK3 |
0.831 | 0.273 | -3 | 0.856 |
CAMK2B |
0.831 | 0.168 | 2 | 0.773 |
MARK4 |
0.831 | 0.059 | 4 | 0.790 |
MST4 |
0.830 | 0.069 | 2 | 0.815 |
TSSK2 |
0.830 | 0.161 | -5 | 0.825 |
PDHK4 |
0.830 | -0.193 | 1 | 0.830 |
MYLK4 |
0.830 | 0.243 | -2 | 0.843 |
CAMK2G |
0.829 | -0.050 | 2 | 0.796 |
MNK1 |
0.828 | 0.210 | -2 | 0.844 |
RIPK3 |
0.828 | -0.008 | 3 | 0.688 |
P38A |
0.828 | 0.235 | 1 | 0.824 |
P38B |
0.828 | 0.246 | 1 | 0.768 |
IKKE |
0.827 | -0.074 | 1 | 0.701 |
CHAK2 |
0.827 | 0.006 | -1 | 0.856 |
BMPR2 |
0.827 | -0.167 | -2 | 0.836 |
CDK13 |
0.826 | 0.185 | 1 | 0.767 |
CDK10 |
0.826 | 0.270 | 1 | 0.763 |
MELK |
0.826 | 0.156 | -3 | 0.869 |
CDK14 |
0.825 | 0.259 | 1 | 0.774 |
CDK1 |
0.825 | 0.198 | 1 | 0.756 |
JNK3 |
0.825 | 0.221 | 1 | 0.766 |
CDK5 |
0.825 | 0.201 | 1 | 0.802 |
GCN2 |
0.825 | -0.194 | 2 | 0.763 |
CAMK4 |
0.825 | 0.121 | -3 | 0.861 |
TGFBR2 |
0.825 | -0.016 | -2 | 0.751 |
QSK |
0.825 | 0.128 | 4 | 0.770 |
PKCB |
0.825 | 0.134 | 2 | 0.680 |
PDHK1 |
0.824 | -0.158 | 1 | 0.813 |
GRK5 |
0.824 | -0.076 | -3 | 0.790 |
DSTYK |
0.824 | -0.107 | 2 | 0.847 |
ERK1 |
0.824 | 0.210 | 1 | 0.759 |
AKT1 |
0.824 | 0.291 | -3 | 0.823 |
PAK2 |
0.823 | 0.179 | -2 | 0.840 |
AURA |
0.823 | 0.222 | -2 | 0.735 |
PKCA |
0.823 | 0.152 | 2 | 0.669 |
IKKA |
0.823 | -0.018 | -2 | 0.696 |
CDK12 |
0.822 | 0.200 | 1 | 0.743 |
PKCG |
0.822 | 0.118 | 2 | 0.686 |
NIM1 |
0.822 | 0.019 | 3 | 0.727 |
CDK17 |
0.822 | 0.207 | 1 | 0.689 |
P38G |
0.821 | 0.215 | 1 | 0.685 |
CDK9 |
0.821 | 0.179 | 1 | 0.774 |
MOK |
0.821 | 0.355 | 1 | 0.852 |
AKT3 |
0.821 | 0.321 | -3 | 0.769 |
ULK2 |
0.821 | -0.194 | 2 | 0.736 |
HUNK |
0.821 | -0.090 | 2 | 0.770 |
NEK6 |
0.821 | -0.062 | -2 | 0.810 |
DCAMKL1 |
0.821 | 0.198 | -3 | 0.868 |
MASTL |
0.821 | -0.097 | -2 | 0.794 |
WNK3 |
0.819 | -0.128 | 1 | 0.778 |
SIK |
0.819 | 0.128 | -3 | 0.830 |
PHKG1 |
0.819 | 0.080 | -3 | 0.877 |
BMPR1B |
0.819 | 0.087 | 1 | 0.772 |
MLK2 |
0.818 | -0.014 | 2 | 0.772 |
PKCZ |
0.818 | 0.103 | 2 | 0.729 |
GRK6 |
0.818 | -0.034 | 1 | 0.792 |
BCKDK |
0.818 | -0.135 | -1 | 0.792 |
CDK3 |
0.818 | 0.187 | 1 | 0.707 |
RIPK1 |
0.818 | -0.060 | 1 | 0.781 |
NUAK1 |
0.817 | 0.087 | -3 | 0.856 |
CAMK1G |
0.817 | 0.162 | -3 | 0.831 |
BRSK1 |
0.817 | 0.095 | -3 | 0.859 |
IRE1 |
0.817 | -0.027 | 1 | 0.784 |
PASK |
0.817 | 0.236 | -3 | 0.894 |
CHK1 |
0.816 | 0.131 | -3 | 0.865 |
MLK1 |
0.816 | -0.140 | 2 | 0.762 |
GRK7 |
0.816 | 0.082 | 1 | 0.743 |
CDK16 |
0.816 | 0.211 | 1 | 0.705 |
QIK |
0.816 | 0.021 | -3 | 0.855 |
MPSK1 |
0.816 | 0.230 | 1 | 0.818 |
CAMK1D |
0.815 | 0.231 | -3 | 0.795 |
NEK7 |
0.815 | -0.194 | -3 | 0.785 |
PAK5 |
0.815 | 0.219 | -2 | 0.749 |
FAM20C |
0.815 | 0.034 | 2 | 0.614 |
P70S6K |
0.815 | 0.201 | -3 | 0.799 |
SGK1 |
0.815 | 0.287 | -3 | 0.750 |
MARK3 |
0.814 | 0.068 | 4 | 0.729 |
MLK3 |
0.814 | -0.008 | 2 | 0.691 |
PAK4 |
0.814 | 0.231 | -2 | 0.756 |
P38D |
0.814 | 0.222 | 1 | 0.698 |
DLK |
0.814 | -0.108 | 1 | 0.789 |
ERK2 |
0.814 | 0.155 | 1 | 0.791 |
ALK4 |
0.813 | -0.004 | -2 | 0.787 |
PKCH |
0.813 | 0.081 | 2 | 0.663 |
MAPKAPK5 |
0.813 | 0.093 | -3 | 0.800 |
TGFBR1 |
0.812 | 0.019 | -2 | 0.757 |
BRSK2 |
0.812 | 0.034 | -3 | 0.863 |
SMMLCK |
0.812 | 0.204 | -3 | 0.860 |
PKR |
0.811 | 0.012 | 1 | 0.824 |
NEK9 |
0.811 | -0.154 | 2 | 0.789 |
ANKRD3 |
0.811 | -0.122 | 1 | 0.814 |
DAPK3 |
0.811 | 0.262 | -3 | 0.868 |
VRK2 |
0.811 | -0.018 | 1 | 0.856 |
PRP4 |
0.811 | 0.132 | -3 | 0.729 |
IRE2 |
0.810 | -0.020 | 2 | 0.689 |
SBK |
0.810 | 0.279 | -3 | 0.718 |
GSK3A |
0.810 | 0.124 | 4 | 0.476 |
DNAPK |
0.809 | 0.022 | 1 | 0.666 |
BUB1 |
0.809 | 0.288 | -5 | 0.796 |
MARK2 |
0.809 | 0.028 | 4 | 0.695 |
SSTK |
0.808 | 0.104 | 4 | 0.755 |
GRK4 |
0.808 | -0.146 | -2 | 0.787 |
ATM |
0.807 | -0.071 | 1 | 0.714 |
CDK2 |
0.807 | 0.070 | 1 | 0.809 |
ULK1 |
0.807 | -0.246 | -3 | 0.742 |
ROCK2 |
0.807 | 0.289 | -3 | 0.866 |
PKCT |
0.807 | 0.122 | 2 | 0.669 |
TTBK2 |
0.807 | -0.168 | 2 | 0.683 |
NEK2 |
0.807 | -0.054 | 2 | 0.771 |
MEK1 |
0.806 | -0.130 | 2 | 0.804 |
MRCKB |
0.806 | 0.266 | -3 | 0.826 |
DCAMKL2 |
0.806 | 0.093 | -3 | 0.870 |
DAPK1 |
0.806 | 0.249 | -3 | 0.853 |
CAMK1A |
0.805 | 0.240 | -3 | 0.778 |
WNK4 |
0.805 | 0.018 | -2 | 0.887 |
GSK3B |
0.805 | 0.067 | 4 | 0.468 |
PKCE |
0.805 | 0.162 | 2 | 0.671 |
MARK1 |
0.805 | 0.016 | 4 | 0.741 |
YSK4 |
0.804 | -0.095 | 1 | 0.745 |
DMPK1 |
0.804 | 0.318 | -3 | 0.849 |
CHK2 |
0.804 | 0.218 | -3 | 0.764 |
MRCKA |
0.804 | 0.245 | -3 | 0.836 |
MST3 |
0.804 | 0.056 | 2 | 0.797 |
PKCI |
0.803 | 0.104 | 2 | 0.697 |
SMG1 |
0.803 | -0.067 | 1 | 0.744 |
TLK2 |
0.803 | -0.053 | 1 | 0.749 |
ALK2 |
0.803 | -0.022 | -2 | 0.770 |
SNRK |
0.803 | -0.063 | 2 | 0.635 |
CHAK1 |
0.803 | -0.122 | 2 | 0.744 |
JNK1 |
0.802 | 0.171 | 1 | 0.728 |
PLK1 |
0.802 | -0.131 | -2 | 0.733 |
DRAK1 |
0.802 | -0.020 | 1 | 0.720 |
ACVR2B |
0.801 | -0.042 | -2 | 0.739 |
ACVR2A |
0.800 | -0.051 | -2 | 0.725 |
PKN1 |
0.800 | 0.156 | -3 | 0.817 |
MLK4 |
0.800 | -0.104 | 2 | 0.667 |
PHKG2 |
0.799 | 0.043 | -3 | 0.849 |
GAK |
0.799 | 0.135 | 1 | 0.864 |
CDK4 |
0.798 | 0.185 | 1 | 0.734 |
CK1E |
0.798 | -0.023 | -3 | 0.509 |
CRIK |
0.798 | 0.284 | -3 | 0.829 |
CDK6 |
0.798 | 0.170 | 1 | 0.755 |
IRAK4 |
0.797 | -0.041 | 1 | 0.777 |
ERK7 |
0.797 | 0.075 | 2 | 0.519 |
NEK5 |
0.797 | -0.035 | 1 | 0.799 |
GRK2 |
0.797 | -0.067 | -2 | 0.682 |
MEK5 |
0.796 | -0.166 | 2 | 0.778 |
LKB1 |
0.796 | 0.074 | -3 | 0.798 |
TAO3 |
0.795 | -0.010 | 1 | 0.774 |
BRAF |
0.794 | -0.087 | -4 | 0.835 |
PERK |
0.793 | -0.149 | -2 | 0.785 |
PLK4 |
0.793 | -0.128 | 2 | 0.588 |
PKG1 |
0.793 | 0.200 | -2 | 0.685 |
PLK3 |
0.793 | -0.151 | 2 | 0.745 |
BMPR1A |
0.793 | -0.003 | 1 | 0.739 |
PINK1 |
0.792 | -0.121 | 1 | 0.856 |
CK1D |
0.792 | -0.008 | -3 | 0.463 |
MEKK2 |
0.792 | -0.119 | 2 | 0.758 |
GCK |
0.792 | 0.070 | 1 | 0.786 |
PBK |
0.792 | 0.163 | 1 | 0.806 |
PDK1 |
0.791 | 0.033 | 1 | 0.752 |
MEKK1 |
0.791 | -0.164 | 1 | 0.771 |
ROCK1 |
0.791 | 0.249 | -3 | 0.837 |
CAMKK2 |
0.791 | -0.017 | -2 | 0.750 |
HPK1 |
0.790 | 0.074 | 1 | 0.776 |
CK1A2 |
0.790 | -0.015 | -3 | 0.469 |
ZAK |
0.790 | -0.166 | 1 | 0.733 |
MEKK3 |
0.789 | -0.209 | 1 | 0.777 |
TNIK |
0.789 | 0.064 | 3 | 0.802 |
TLK1 |
0.788 | -0.150 | -2 | 0.776 |
KHS1 |
0.788 | 0.118 | 1 | 0.768 |
HRI |
0.788 | -0.230 | -2 | 0.796 |
LOK |
0.787 | 0.049 | -2 | 0.768 |
MEKK6 |
0.787 | -0.014 | 1 | 0.772 |
TAO2 |
0.787 | -0.069 | 2 | 0.793 |
HGK |
0.785 | 0.001 | 3 | 0.800 |
NEK4 |
0.785 | -0.053 | 1 | 0.772 |
KHS2 |
0.785 | 0.104 | 1 | 0.782 |
CAMKK1 |
0.785 | -0.136 | -2 | 0.743 |
NEK11 |
0.785 | -0.144 | 1 | 0.757 |
LRRK2 |
0.785 | -0.029 | 2 | 0.804 |
CK1G1 |
0.784 | -0.071 | -3 | 0.489 |
NEK8 |
0.784 | -0.123 | 2 | 0.768 |
PDHK3_TYR |
0.784 | 0.314 | 4 | 0.845 |
MAP3K15 |
0.784 | -0.030 | 1 | 0.725 |
CK2A2 |
0.784 | 0.016 | 1 | 0.687 |
NEK1 |
0.782 | -0.005 | 1 | 0.775 |
MINK |
0.782 | -0.033 | 1 | 0.771 |
GRK3 |
0.782 | -0.071 | -2 | 0.646 |
SLK |
0.779 | -0.027 | -2 | 0.707 |
TAK1 |
0.779 | -0.072 | 1 | 0.770 |
IRAK1 |
0.778 | -0.249 | -1 | 0.773 |
MST2 |
0.777 | -0.119 | 1 | 0.783 |
TTBK1 |
0.777 | -0.200 | 2 | 0.607 |
VRK1 |
0.777 | -0.114 | 2 | 0.793 |
EEF2K |
0.777 | -0.084 | 3 | 0.751 |
HASPIN |
0.777 | 0.077 | -1 | 0.739 |
LIMK2_TYR |
0.776 | 0.224 | -3 | 0.872 |
CK2A1 |
0.775 | 0.007 | 1 | 0.667 |
STK33 |
0.774 | -0.112 | 2 | 0.588 |
TESK1_TYR |
0.774 | 0.138 | 3 | 0.830 |
PDHK4_TYR |
0.773 | 0.133 | 2 | 0.842 |
MST1 |
0.773 | -0.096 | 1 | 0.768 |
YSK1 |
0.772 | -0.058 | 2 | 0.763 |
MAP2K4_TYR |
0.771 | 0.112 | -1 | 0.885 |
BIKE |
0.771 | 0.112 | 1 | 0.778 |
PKMYT1_TYR |
0.770 | 0.063 | 3 | 0.798 |
MAP2K6_TYR |
0.769 | 0.052 | -1 | 0.892 |
PLK2 |
0.767 | -0.107 | -3 | 0.665 |
MYO3B |
0.766 | 0.017 | 2 | 0.779 |
MAP2K7_TYR |
0.766 | -0.073 | 2 | 0.821 |
MEK2 |
0.766 | -0.231 | 2 | 0.769 |
BMPR2_TYR |
0.764 | 0.016 | -1 | 0.880 |
YANK3 |
0.764 | -0.032 | 2 | 0.397 |
AAK1 |
0.764 | 0.173 | 1 | 0.700 |
PDHK1_TYR |
0.763 | -0.016 | -1 | 0.895 |
OSR1 |
0.762 | -0.074 | 2 | 0.756 |
RIPK2 |
0.762 | -0.266 | 1 | 0.692 |
NEK3 |
0.762 | -0.131 | 1 | 0.729 |
PINK1_TYR |
0.761 | -0.103 | 1 | 0.816 |
TTK |
0.760 | -0.083 | -2 | 0.763 |
ASK1 |
0.758 | -0.103 | 1 | 0.710 |
EPHA6 |
0.757 | 0.009 | -1 | 0.846 |
LIMK1_TYR |
0.757 | -0.084 | 2 | 0.808 |
RET |
0.757 | -0.059 | 1 | 0.771 |
TNK2 |
0.755 | 0.050 | 3 | 0.707 |
MYO3A |
0.755 | -0.079 | 1 | 0.772 |
EPHB4 |
0.755 | -0.005 | -1 | 0.818 |
TAO1 |
0.754 | -0.092 | 1 | 0.699 |
ABL2 |
0.754 | 0.024 | -1 | 0.797 |
MST1R |
0.752 | -0.114 | 3 | 0.759 |
DDR1 |
0.752 | -0.104 | 4 | 0.761 |
CK1A |
0.752 | -0.054 | -3 | 0.375 |
FGR |
0.751 | -0.020 | 1 | 0.836 |
TXK |
0.751 | 0.049 | 1 | 0.800 |
ROS1 |
0.751 | -0.096 | 3 | 0.709 |
TYRO3 |
0.751 | -0.115 | 3 | 0.739 |
TNK1 |
0.751 | 0.034 | 3 | 0.727 |
ABL1 |
0.750 | -0.005 | -1 | 0.790 |
JAK2 |
0.749 | -0.124 | 1 | 0.759 |
YES1 |
0.749 | -0.059 | -1 | 0.858 |
TYK2 |
0.749 | -0.200 | 1 | 0.764 |
ALPHAK3 |
0.747 | -0.131 | -1 | 0.772 |
TNNI3K_TYR |
0.747 | 0.016 | 1 | 0.791 |
LCK |
0.746 | 0.002 | -1 | 0.838 |
CSF1R |
0.746 | -0.135 | 3 | 0.731 |
NEK10_TYR |
0.744 | -0.060 | 1 | 0.656 |
ITK |
0.744 | -0.068 | -1 | 0.801 |
JAK3 |
0.744 | -0.149 | 1 | 0.739 |
EPHA4 |
0.743 | -0.062 | 2 | 0.746 |
BLK |
0.743 | 0.002 | -1 | 0.841 |
DDR2 |
0.742 | 0.031 | 3 | 0.673 |
HCK |
0.742 | -0.101 | -1 | 0.835 |
INSRR |
0.741 | -0.147 | 3 | 0.690 |
FER |
0.741 | -0.175 | 1 | 0.822 |
KDR |
0.741 | -0.096 | 3 | 0.699 |
SRMS |
0.741 | -0.112 | 1 | 0.801 |
FGFR2 |
0.740 | -0.154 | 3 | 0.745 |
EPHB3 |
0.739 | -0.084 | -1 | 0.798 |
EPHB1 |
0.739 | -0.121 | 1 | 0.793 |
JAK1 |
0.739 | -0.076 | 1 | 0.706 |
MERTK |
0.739 | -0.078 | 3 | 0.728 |
AXL |
0.738 | -0.110 | 3 | 0.725 |
STLK3 |
0.737 | -0.220 | 1 | 0.708 |
EPHB2 |
0.736 | -0.105 | -1 | 0.790 |
PDGFRB |
0.736 | -0.216 | 3 | 0.740 |
BMX |
0.736 | -0.074 | -1 | 0.717 |
FYN |
0.735 | -0.024 | -1 | 0.828 |
TEK |
0.735 | -0.168 | 3 | 0.672 |
MET |
0.735 | -0.122 | 3 | 0.740 |
KIT |
0.733 | -0.198 | 3 | 0.729 |
FGFR1 |
0.733 | -0.197 | 3 | 0.710 |
WEE1_TYR |
0.733 | -0.110 | -1 | 0.744 |
TEC |
0.731 | -0.133 | -1 | 0.727 |
EPHA1 |
0.731 | -0.100 | 3 | 0.717 |
EPHA7 |
0.730 | -0.095 | 2 | 0.738 |
FLT3 |
0.730 | -0.255 | 3 | 0.737 |
PTK2B |
0.729 | -0.058 | -1 | 0.767 |
EPHA3 |
0.729 | -0.136 | 2 | 0.714 |
LTK |
0.729 | -0.154 | 3 | 0.675 |
ALK |
0.729 | -0.180 | 3 | 0.654 |
FGFR3 |
0.727 | -0.183 | 3 | 0.715 |
BTK |
0.727 | -0.250 | -1 | 0.762 |
PDGFRA |
0.727 | -0.270 | 3 | 0.733 |
FLT1 |
0.726 | -0.165 | -1 | 0.818 |
PTK6 |
0.725 | -0.231 | -1 | 0.727 |
NTRK1 |
0.724 | -0.255 | -1 | 0.803 |
PTK2 |
0.724 | -0.006 | -1 | 0.797 |
LYN |
0.723 | -0.147 | 3 | 0.652 |
CK1G3 |
0.723 | -0.092 | -3 | 0.330 |
YANK2 |
0.722 | -0.096 | 2 | 0.411 |
SRC |
0.722 | -0.110 | -1 | 0.819 |
FRK |
0.722 | -0.177 | -1 | 0.826 |
ERBB2 |
0.722 | -0.227 | 1 | 0.717 |
INSR |
0.721 | -0.225 | 3 | 0.670 |
EPHA5 |
0.721 | -0.126 | 2 | 0.724 |
NTRK3 |
0.720 | -0.170 | -1 | 0.755 |
NTRK2 |
0.719 | -0.281 | 3 | 0.699 |
EPHA8 |
0.719 | -0.124 | -1 | 0.791 |
FLT4 |
0.719 | -0.258 | 3 | 0.684 |
MATK |
0.718 | -0.169 | -1 | 0.715 |
CSK |
0.714 | -0.200 | 2 | 0.744 |
SYK |
0.714 | -0.063 | -1 | 0.773 |
EGFR |
0.714 | -0.158 | 1 | 0.622 |
FGFR4 |
0.711 | -0.170 | -1 | 0.749 |
EPHA2 |
0.709 | -0.126 | -1 | 0.751 |
IGF1R |
0.706 | -0.202 | 3 | 0.613 |
CK1G2 |
0.705 | -0.095 | -3 | 0.414 |
ERBB4 |
0.705 | -0.120 | 1 | 0.647 |
MUSK |
0.702 | -0.211 | 1 | 0.626 |
ZAP70 |
0.699 | -0.054 | -1 | 0.704 |
FES |
0.690 | -0.219 | -1 | 0.692 |