Motif 190 (n=237)

Position-wise Probabilities

Download
uniprot genes site source protein function
A0A0C4DFX4 None S2548 ochoa Snf2 related CREBBP activator protein None
A0A0C4DFX4 None S2620 ochoa Snf2 related CREBBP activator protein None
A1X283 SH3PXD2B S293 ochoa SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
A6ND36 FAM83G S650 ochoa Protein FAM83G (Protein associated with SMAD1) Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}.
A6NFX1 MFSD2B S26 ochoa Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b) Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). {ECO:0000250|UniProtKB:Q3T9M1, ECO:0000269|PubMed:29045386, ECO:0000305|PubMed:29563527}.
A6NI28 ARHGAP42 S587 ochoa Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}.
C9JH25 PRRT4 S731 ochoa Proline-rich transmembrane protein 4 None
H0YIS7 RNASEK-C17orf49 S163 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}.
K7ELQ4 ATF7-NPFF S244 ochoa ATF7-NPFF readthrough None
O00267 SUPT5H S866 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O14514 ADGRB1 S1306 ochoa Adhesion G protein-coupled receptor B1 (Brain-specific angiogenesis inhibitor 1) [Cleaved into: Vasculostatin-40 (Vstat40); Vasculostatin-120 (Vstat120)] Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}.
O14686 KMT2D S1872 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14994 SYN3 S491 ochoa Synapsin-3 (Synapsin III) May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15034 RIMBP2 S651 ochoa RIMS-binding protein 2 (RIM-BP2) Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}.
O43189 PHF1 S522 ochoa PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1) Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464, PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. {ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:18385154, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23150668, ECO:0000269|PubMed:23273982}.
O43294 TGFB1I1 S37 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43294 TGFB1I1 S80 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43379 WDR62 S1049 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O43395 PRPF3 S176 ochoa U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}.
O43426 SYNJ1 S1292 ochoa Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}.
O43561 LAT S91 ochoa Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}.
O43896 KIF1C S1022 ochoa Kinesin-like protein KIF1C Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}.
O60307 MAST3 S1136 ochoa Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) None
O60356 NUPR1 S23 ochoa Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}.
O75081 CBFA2T3 S459 ochoa Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}.
O75116 ROCK2 S1361 ochoa Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
O75369 FLNB S1035 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75385 ULK1 S694 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75385 ULK1 S775 ochoa Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}.
O75815 BCAR3 S370 ochoa Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}.
O75962 TRIO S2499 ochoa Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}.
O94967 WDR47 S304 ochoa WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) None
O95251 KAT7 S135 ochoa Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.
O95382 MAP3K6 S964 ochoa|psp Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}.
O95503 CBX6 S273 ochoa Chromobox protein homolog 6 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}.
O95721 SNAP29 Y44 ochoa Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}.
O95817 BAG3 Y93 ochoa BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}.
P12755 SKI S404 ochoa Ski oncogene (Proto-oncogene c-Ski) May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}.
P14317 HCLS1 S299 ochoa Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
P15336 ATF2 S265 ochoa Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.
P15822 HIVEP1 S698 ochoa Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
P17936 IGFBP3 S140 ochoa|psp Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3) Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269|PubMed:10874028, ECO:0000269|PubMed:15371331, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19556345, ECO:0000269|PubMed:19623253, ECO:0000269|PubMed:19952275, ECO:0000269|PubMed:20353938}.
P18669 PGAM1 S134 ochoa Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}.
P23396 RPS3 S209 ochoa|psp Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}.
P27708 CAD S1900 ochoa|psp Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}.
P29353 SHC1 S388 ochoa SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}.
P30622 CLIP1 S180 ochoa CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.
P35269 GTF2F1 S449 ochoa General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
P46013 MKI67 S704 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46109 CRKL S112 ochoa Crk-like protein May mediate the transduction of intracellular signals.
P46379 BAG6 S985 ochoa Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:Q9Z1R2, ECO:0000269|PubMed:20516149, ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269|PubMed:17403783, ECO:0000269|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269|PubMed:18055229, ECO:0000269|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269|PubMed:14960581}.
P46531 NOTCH1 S2523 psp Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.
P47974 ZFP36L2 S261 ochoa mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}.
P50851 LRBA S1787 ochoa Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}.
P51825 AFF1 S216 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P53367 ARFIP1 S81 ochoa Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.
P54259 ATN1 S887 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P54829 PTPN5 S184 psp Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}.
Q00610 CLTC S67 ochoa Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q02086 SP2 S187 ochoa Transcription factor Sp2 Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Q02750 MAP2K1 S299 ochoa Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}.
Q05209 PTPN12 S684 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q07157 TJP1 S1577 ochoa Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
Q07889 SOS1 S1161 ochoa|psp Son of sevenless homolog 1 (SOS-1) Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}.
Q09472 EP300 S19 psp Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.
Q0JRZ9 FCHO2 S508 ochoa F-BAR domain only protein 2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Q12774 ARHGEF5 T735 ochoa Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}.
Q12802 AKAP13 S1876 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q12815 TROAP S344 ochoa Tastin (Trophinin-assisting protein) (Trophinin-associated protein) Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.
Q12948 FOXC1 S248 ochoa Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}.
Q12986 NFX1 S1095 ochoa Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}.
Q13094 LCP2 S417 ochoa Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}.
Q13263 TRIM28 S103 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13415 ORC1 S478 ochoa Origin recognition complex subunit 1 (Replication control protein 1) Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Q13424 SNTA1 S200 ochoa Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1) Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.
Q13444 ADAM15 S832 ochoa Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin) Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.
Q13459 MYO9B S2049 ochoa Unconventional myosin-IXb (Unconventional myosin-9b) Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}.
Q13573 SNW1 S234 ochoa SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}.
Q13596 SNX1 S25 ochoa Sorting nexin-1 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}.
Q13796 SHROOM2 S325 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13905 RAPGEF1 S293 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q13905 RAPGEF1 S463 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q14135 VGLL4 S59 ochoa Transcription cofactor vestigial-like protein 4 (Vgl-4) May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}.
Q14247 CTTN S417 ochoa Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14686 NCOA6 S1231 ochoa Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q14847 LASP1 S198 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q14CS0 UBXN2B S66 ochoa UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}.
Q15569 TESK1 S437 ochoa Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}.
Q15654 TRIP6 Y149 ochoa Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}.
Q15678 PTPN14 S534 ochoa Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}.
Q15772 SPEG S435 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15772 SPEG S2296 ochoa Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15797 SMAD1 S239 psp Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.
Q15942 ZYX S143 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q2LD37 BLTP1 S4607 ochoa Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}.
Q3KQU3 MAP7D1 S88 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q3YEC7 RABL6 S464 ochoa Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269|PubMed:16582619}.
Q4KMP7 TBC1D10B S107 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q4KMP7 TBC1D10B S248 ochoa TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q4KMQ1 TPRN S369 ochoa Taperin Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}.
Q504U0 C4orf46 S23 ochoa Renal cancer differentiation gene 1 protein None
Q53HC0 CCDC92 S211 ochoa Coiled-coil domain-containing protein 92 (Limkain beta-2) Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}.
Q5FWE3 PRRT3 S815 ochoa Proline-rich transmembrane protein 3 None
Q5JRA6 MIA3 S1882 ochoa Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:28442536}.
Q5JRC9 FAM47A S541 ochoa Protein FAM47A None
Q5SQI0 ATAT1 S272 ochoa Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}.
Q5T011 SZT2 S2143 ochoa KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). {ECO:0000250|UniProtKB:A2A9C3, ECO:0000269|PubMed:28199306, ECO:0000269|PubMed:28199315}.
Q5T0Z8 C6orf132 S456 ochoa Uncharacterized protein C6orf132 None
Q5T1R4 HIVEP3 S542 ochoa|psp Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}.
Q5VST9 OBSCN S4628 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VWQ0 RSBN1 S554 ochoa Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}.
Q5VY43 PEAR1 S964 ochoa Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}.
Q641Q2 WASHC2A S990 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q66K64 DCAF15 S359 ochoa DDB1- and CUL4-associated factor 15 Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:31452512}.; FUNCTION: Binding of aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, change the substrate specificity of the DCX(DCAF15) complex, leading to promote ubiquitination and degradation of splicing factor RBM39 (PubMed:28302793, PubMed:28437394, PubMed:31452512, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs also promote ubiquitination and degradation of RBM23 and PRPF39 (PubMed:31626998, PubMed:31686031, PubMed:31693891). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31452512, ECO:0000269|PubMed:31626998, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}.
Q66K74 MAP1S S766 ochoa Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}.
Q6F5E8 CARMIL2 S1362 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6GQQ9 OTUD7B S745 ochoa OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}.
Q6NY19 KANK3 S31 ochoa KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47) May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Q6P0Q8 MAST2 S1722 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P2Q9 PRPF8 S26 ochoa Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:10411133, ECO:0000269|PubMed:11971955, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453, ECO:0000303|PubMed:15840809}.
Q6P4Q7 CNNM4 S662 ochoa Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}.
Q6UWF3 SCIMP S90 ochoa SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}.
Q6WCQ1 MPRIP S372 ochoa Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.
Q6ZRS2 SRCAP S2725 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZRS2 SRCAP S2797 ochoa Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}.
Q6ZU35 CRACD S133 ochoa Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. {ECO:0000269|PubMed:30361697}.
Q6ZUM4 ARHGAP27 S451 ochoa Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q7L2K0 TEDC2 S159 ochoa Tubulin epsilon and delta complex protein 2 Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}.
Q7Z5H3 ARHGAP22 S395 ochoa|psp Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
Q7Z5J4 RAI1 S670 ochoa Retinoic acid-induced protein 1 Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
Q86SQ0 PHLDB2 S116 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86TP1 PRUNE1 S414 ochoa Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.
Q86U70 LDB1 S294 ochoa LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.
Q86UW9 DTX2 S236 ochoa Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Q86YD1 PTOV1 S53 ochoa|psp Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}.
Q86YV0 RASAL3 S72 ochoa RAS protein activator like-3 Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
Q86YW5 TREML1 S276 ochoa Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}.
Q8IV50 LYSMD2 S29 ochoa LysM and putative peptidoglycan-binding domain-containing protein 2 None
Q8IV56 PRR15 S56 ochoa Proline-rich protein 15 May have a role in proliferation and/or differentiation. {ECO:0000250}.
Q8IX21 SLF2 S578 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IXM2 BACC1 S122 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Q8IY18 SMC5 S35 ochoa Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}.
Q8IY67 RAVER1 S474 ochoa Ribonucleoprotein PTB-binding 1 (Protein raver-1) Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). {ECO:0000250}.
Q8IY92 SLX4 S1354 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8N0Y7 PGAM4 S134 ochoa Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) None
Q8N122 RPTOR S721 ochoa|psp Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}.
Q8N1G1 REXO1 S365 ochoa RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}.
Q8N2Y8 RUSC2 S543 ochoa AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.
Q8N3E9 PLCD3 S556 ochoa 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow (PubMed:10336610). Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). {ECO:0000250|UniProtKB:Q8K2J0, ECO:0000269|PubMed:10336610}.
Q8N3L3 TXLNB S50 ochoa Beta-taxilin (Muscle-derived protein 77) (hMDP77) Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}.
Q8N4B1 PHETA1 S213 ochoa Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase-interacting protein A) (IPIP27A) (PH domain-containing endocytic trafficking adaptor 1) Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. {ECO:0000269|PubMed:21233288}.
Q8N5H7 SH2D3C S447 ochoa SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}.
Q8N8E2 ZNF513 S522 ochoa Zinc finger protein 513 Transcriptional regulator that plays a role in retinal development and maintenance. {ECO:0000269|PubMed:20797688}.
Q8NCD3 HJURP S649 ochoa Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.
Q8NDX1 PSD4 S921 ochoa PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Q8NFH5 NUP35 S55 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NFY4 SEMA6D S957 ochoa Semaphorin-6D Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}.
Q8TC05 MDM1 S642 ochoa Nuclear protein MDM1 Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.
Q8TCU6 PREX1 S31 ochoa Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Q8TDM6 DLG5 S1021 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TDZ2 MICAL1 S774 ochoa [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}.
Q8TE67 EPS8L3 S445 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) None
Q8TEK3 DOT1L S1008 ochoa Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}.
Q8TF72 SHROOM3 S754 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q8WUF5 PPP1R13L S65 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WUF5 PPP1R13L S74 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WWM7 ATXN2L S630 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WXE0 CASKIN2 S800 ochoa Caskin-2 (CASK-interacting protein 2) None
Q92538 GBF1 S1781 ochoa Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}.
Q92918 MAP4K1 S405 ochoa Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}.
Q92918 MAP4K1 S407 ochoa Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}.
Q96AP7 ESAM S366 ochoa Endothelial cell-selective adhesion molecule Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}.
Q96AP7 ESAM S368 ochoa Endothelial cell-selective adhesion molecule Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}.
Q96D71 REPS1 S556 ochoa RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96FS4 SIPA1 S74 ochoa Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}.
Q96HJ3 CCDC34 S62 ochoa Coiled-coil domain-containing protein 34 (Renal carcinoma antigen NY-REN-41) Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella. {ECO:0000269|PubMed:34348960}.
Q96HZ4 HES6 S183 psp Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6) Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.
Q96I25 RBM17 S229 ochoa Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.
Q96J84 KIRREL1 T679 ochoa Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}.
Q96MX3 ZNF48 S420 ochoa Zinc finger protein 48 (Zinc finger protein 553) May be involved in transcriptional regulation.
Q96PU5 NEDD4L S365 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96RT1 ERBIN S1286 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96T58 SPEN S2387 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99501 GAS2L1 S352 ochoa|psp GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q9BXH1 BBC3 S96 psp Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). {ECO:0000250|UniProtKB:Q99ML1, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}.
Q9BXK5 BCL2L13 S353 ochoa Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) May promote the activation of caspase-3 and apoptosis.
Q9BYE7 PCGF6 S233 ochoa Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000269|PubMed:12167161, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}.
Q9C0A6 SETD5 S865 ochoa Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}.
Q9C0B5 ZDHHC5 S321 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9GZV9 FGF23 S212 psp Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] Regulator of phosphate homeostasis (PubMed:11062477). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (PubMed:11409890). Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (PubMed:15040831). Negatively regulates osteoblast differentiation and matrix mineralization (PubMed:18282132). {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.
Q9H0H5 RACGAP1 S203 ochoa Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}.
Q9H1K0 RBSN S592 ochoa Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}.
Q9H330 TMEM245 S30 ochoa Transmembrane protein 245 (Protein CG-2) None
Q9H3P2 NELFA S353 ochoa Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
Q9H3T3 SEMA6B S749 ochoa Semaphorin-6B (Semaphorin-Z) (Sema Z) Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}.
Q9H4L4 SENP3 S44 ochoa Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H6K5 PRR36 S1111 ochoa Proline-rich protein 36 None
Q9H7N4 SCAF1 S552 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7N4 SCAF1 S674 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7N4 SCAF1 S992 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9 PLEKHG2 S1334 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9HB07 MYG1 S39 ochoa MYG1 exonuclease (EC 3.1.-.-) 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}.
Q9HB20 PLEKHA3 S211 ochoa Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.
Q9HC77 CPAP S1109 ochoa|psp Centrosomal P4.1-associated protein (Centromere protein J) (CENP-J) (Centrosome assembly and centriole elongation protein) (LAG-3-associated protein) (LYST-interacting protein 1) Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as a microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). {ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064, ECO:0000305|PubMed:27306797}.
Q9HCC9 ZFYVE28 S394 ochoa Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}.
Q9NPB6 PARD6A S282 ochoa Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.
Q9NQC1 JADE2 S119 ochoa E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}.
Q9NQC1 JADE2 S617 ochoa E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6ZQF7, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:25018020}.
Q9NQC3 RTN4 S182 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NRA0 SPHK2 S399 ochoa Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Q9NUE0 ZDHHC18 S49 ochoa Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269|PubMed:23034182, ECO:0000269|PubMed:27481942, ECO:0000269|PubMed:35438208}.
Q9NVR5 DNAAF2 S240 ochoa Protein kintoun (Dynein assembly factor 2, axonemal) Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}.
Q9NW97 TMEM51 S192 ochoa Transmembrane protein 51 None
Q9P202 WHRN S685 ochoa Whirlin (Autosomal recessive deafness type 31 protein) Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}.
Q9P206 NHSL3 S858 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P275 USP36 S763 ochoa Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}.
Q9P2P5 HECW2 S850 ochoa E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). {ECO:0000269|PubMed:12890487, ECO:0000269|PubMed:24163370}.
Q9UHB6 LIMA1 S369 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UIJ5 ZDHHC2 S333 ochoa Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844). {ECO:0000250|UniProtKB:P59267, ECO:0000250|UniProtKB:Q9JKR5, ECO:0000269|PubMed:18296695, ECO:0000269|PubMed:18508921, ECO:0000269|PubMed:19144824, ECO:0000269|PubMed:21343290, ECO:0000269|PubMed:22034844, ECO:0000269|PubMed:23793055}.; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. {ECO:0000269|PubMed:30404808}.
Q9UJF2 RASAL2 S802 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UJM3 ERRFI1 S302 ochoa|psp ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9ULC8 ZDHHC8 S606 ochoa Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}.
Q9ULW0 TPX2 S646 ochoa Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}.
Q9UPW6 SATB2 S610 ochoa DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}.
Q9UQ35 SRRM2 S2171 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y2F5 ICE1 S1910 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y3L3 SH3BP1 S596 ochoa SH3 domain-binding protein 1 GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
Q9Y3Q8 TSC22D4 S165 ochoa TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
Q9Y446 PKP3 S285 ochoa|psp Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y4K4 MAP4K5 S399 ochoa Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
Q9Y4K4 MAP4K5 S400 ochoa Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.
P08684 CYP3A4 S116 EPSD|PSP Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}.
P12830 CDH1 S36 SIGNOR Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000250|UniProtKB:F1PAA9, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575, ECO:0000269|PubMed:29999492}.; FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.; FUNCTION: (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {ECO:0000269|PubMed:10406800, ECO:0000269|PubMed:17540170, ECO:0000269|PubMed:8601315}.
Q4VCS5 AMOT S852 EPSD Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q92620 DHX38 S438 Sugiyama Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). {ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:9524131, ECO:0000305}.
Q9C0C2 TNKS1BP1 S77 Sugiyama 182 kDa tankyrase-1-binding protein None
Q8TD08 MAPK15 S503 Sugiyama Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}.
Download
reactome_id name p -log10_p
R-HSA-416482 G alpha (12/13) signalling events 0.000009 5.050
R-HSA-193648 NRAGE signals death through JNK 0.000008 5.098
R-HSA-9008059 Interleukin-37 signaling 0.000023 4.641
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.000042 4.375
R-HSA-193704 p75 NTR receptor-mediated signalling 0.000060 4.225
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.000120 3.921
R-HSA-2428933 SHC-related events triggered by IGF1R 0.000120 3.921
R-HSA-9842663 Signaling by LTK 0.000120 3.921
R-HSA-73887 Death Receptor Signaling 0.000083 4.080
R-HSA-9027284 Erythropoietin activates RAS 0.000230 3.639
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.000258 3.589
R-HSA-166520 Signaling by NTRKs 0.000279 3.554
R-HSA-187687 Signalling to ERKs 0.000517 3.287
R-HSA-1227986 Signaling by ERBB2 0.000693 3.159
R-HSA-5654704 SHC-mediated cascade:FGFR3 0.000742 3.130
R-HSA-5654719 SHC-mediated cascade:FGFR4 0.000852 3.069
R-HSA-5654688 SHC-mediated cascade:FGFR1 0.001254 2.902
R-HSA-9034864 Activated NTRK3 signals through RAS 0.001376 2.861
R-HSA-9026519 Activated NTRK2 signals through RAS 0.001673 2.776
R-HSA-5654699 SHC-mediated cascade:FGFR2 0.001771 2.752
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.001675 2.776
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.001783 2.749
R-HSA-5654708 Downstream signaling of activated FGFR3 0.002189 2.660
R-HSA-5654716 Downstream signaling of activated FGFR4 0.002421 2.616
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.002382 2.623
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.002421 2.616
R-HSA-8941856 RUNX3 regulates NOTCH signaling 0.002008 2.697
R-HSA-2424491 DAP12 signaling 0.002421 2.616
R-HSA-170968 Frs2-mediated activation 0.002382 2.623
R-HSA-9006335 Signaling by Erythropoietin 0.002189 2.660
R-HSA-169893 Prolonged ERK activation events 0.003751 2.426
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic... 0.003751 2.426
R-HSA-5654687 Downstream signaling of activated FGFR1 0.004179 2.379
R-HSA-5654696 Downstream signaling of activated FGFR2 0.004179 2.379
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.005517 2.258
R-HSA-2428924 IGF1R signaling cascade 0.005302 2.276
R-HSA-9614657 FOXO-mediated transcription of cell death genes 0.005517 2.258
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.005612 2.251
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.005737 2.241
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.006199 2.208
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.006863 2.163
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.007641 2.117
R-HSA-5654743 Signaling by FGFR4 0.008175 2.088
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.008600 2.066
R-HSA-2172127 DAP12 interactions 0.008732 2.059
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.008537 2.069
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.007708 2.113
R-HSA-3700989 Transcriptional Regulation by TP53 0.008403 2.076
R-HSA-5654741 Signaling by FGFR3 0.009314 2.031
R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.010511 1.978
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.011327 1.946
R-HSA-5654738 Signaling by FGFR2 0.011911 1.924
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.012592 1.900
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.014585 1.836
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.014585 1.836
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.015776 1.802
R-HSA-113418 Formation of the Early Elongation Complex 0.015776 1.802
R-HSA-167287 HIV elongation arrest and recovery 0.015776 1.802
R-HSA-167290 Pausing and recovery of HIV elongation 0.015776 1.802
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.014585 1.836
R-HSA-9758941 Gastrulation 0.015131 1.820
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.017241 1.763
R-HSA-8875555 MET activates RAP1 and RAC1 0.017241 1.763
R-HSA-74749 Signal attenuation 0.017241 1.763
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.017021 1.769
R-HSA-446652 Interleukin-1 family signaling 0.016506 1.782
R-HSA-5654736 Signaling by FGFR1 0.017416 1.759
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.017416 1.759
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.018319 1.737
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.019530 1.709
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.021076 1.676
R-HSA-186763 Downstream signal transduction 0.019671 1.706
R-HSA-8943724 Regulation of PTEN gene transcription 0.021187 1.674
R-HSA-9793380 Formation of paraxial mesoderm 0.022202 1.654
R-HSA-8851805 MET activates RAS signaling 0.025351 1.596
R-HSA-8983432 Interleukin-15 signaling 0.025351 1.596
R-HSA-9707616 Heme signaling 0.023246 1.634
R-HSA-186797 Signaling by PDGF 0.023246 1.634
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.026068 1.584
R-HSA-190236 Signaling by FGFR 0.026972 1.569
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.031457 1.502
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.031457 1.502
R-HSA-180336 SHC1 events in EGFR signaling 0.034705 1.460
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.034247 1.465
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.035324 1.452
R-HSA-446353 Cell-extracellular matrix interactions 0.034705 1.460
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.035565 1.449
R-HSA-201556 Signaling by ALK 0.034247 1.465
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.036133 1.442
R-HSA-167169 HIV Transcription Elongation 0.036133 1.442
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.036133 1.442
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.037119 1.430
R-HSA-9700206 Signaling by ALK in cancer 0.037119 1.430
R-HSA-9694548 Maturation of spike protein 0.038071 1.419
R-HSA-1250347 SHC1 events in ERBB4 signaling 0.041568 1.381
R-HSA-1980143 Signaling by NOTCH1 0.041003 1.387
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.044196 1.355
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.045175 1.345
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.045175 1.345
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.044025 1.356
R-HSA-2028269 Signaling by Hippo 0.045175 1.345
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.039537 1.403
R-HSA-72163 mRNA Splicing - Major Pathway 0.046813 1.330
R-HSA-6806834 Signaling by MET 0.047170 1.326
R-HSA-210993 Tie2 Signaling 0.048893 1.311
R-HSA-9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... 0.048893 1.311
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.059284 1.227
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.059284 1.227
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.059284 1.227
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.059284 1.227
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.059284 1.227
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.059284 1.227
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.059284 1.227
R-HSA-5658034 HHAT G278V doesn't palmitoylate Hh-Np 0.059284 1.227
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.059284 1.227
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.059284 1.227
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.059284 1.227
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.059284 1.227
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.064792 1.188
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.069003 1.161
R-HSA-350054 Notch-HLH transcription pathway 0.069003 1.161
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.069003 1.161
R-HSA-112382 Formation of RNA Pol II elongation complex 0.065278 1.185
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.067860 1.168
R-HSA-72172 mRNA Splicing 0.058126 1.236
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.057812 1.238
R-HSA-167044 Signalling to RAS 0.060671 1.217
R-HSA-5655253 Signaling by FGFR2 in disease 0.060253 1.220
R-HSA-912631 Regulation of signaling by CBL 0.052717 1.278
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.060671 1.217
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.060671 1.217
R-HSA-5684996 MAPK1/MAPK3 signaling 0.055572 1.255
R-HSA-5673001 RAF/MAP kinase cascade 0.049639 1.304
R-HSA-75153 Apoptotic execution phase 0.050781 1.294
R-HSA-9006936 Signaling by TGFB family members 0.057256 1.242
R-HSA-9634597 GPER1 signaling 0.055420 1.256
R-HSA-5683057 MAPK family signaling cascades 0.057331 1.242
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.069003 1.161
R-HSA-212436 Generic Transcription Pathway 0.058695 1.231
R-HSA-9823730 Formation of definitive endoderm 0.056645 1.247
R-HSA-73857 RNA Polymerase II Transcription 0.069514 1.158
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.073550 1.133
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.073550 1.133
R-HSA-8941237 Invadopodia formation 0.073550 1.133
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.087600 1.057
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 0.087600 1.057
R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 0.087600 1.057
R-HSA-9652169 Signaling by MAP2K mutants 0.087600 1.057
R-HSA-5083630 Defective LFNG causes SCDO3 0.087600 1.057
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.101438 0.994
R-HSA-190374 FGFR1c and Klotho ligand binding and activation 0.101438 0.994
R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.115067 0.939
R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.115067 0.939
R-HSA-176417 Phosphorylation of Emi1 0.115067 0.939
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity 0.115067 0.939
R-HSA-9842640 Signaling by LTK in cancer 0.128490 0.891
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.128490 0.891
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.141711 0.849
R-HSA-112412 SOS-mediated signalling 0.141711 0.849
R-HSA-8875656 MET receptor recycling 0.154731 0.810
R-HSA-196025 Formation of annular gap junctions 0.154731 0.810
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.167555 0.776
R-HSA-190873 Gap junction degradation 0.167555 0.776
R-HSA-9700645 ALK mutants bind TKIs 0.167555 0.776
R-HSA-110056 MAPK3 (ERK1) activation 0.180185 0.744
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.192624 0.715
R-HSA-912526 Interleukin receptor SHC signaling 0.073303 1.135
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.073303 1.135
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.073303 1.135
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.082149 1.085
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.086690 1.062
R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.216942 0.664
R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.216942 0.664
R-HSA-179812 GRB2 events in EGFR signaling 0.216942 0.664
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.095988 1.018
R-HSA-190375 FGFR2c ligand binding and activation 0.228825 0.640
R-HSA-190372 FGFR3c ligand binding and activation 0.240529 0.619
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.240529 0.619
R-HSA-177504 Retrograde neurotrophin signalling 0.240529 0.619
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.252057 0.599
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.252057 0.599
R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 0.263409 0.579
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.263409 0.579
R-HSA-1963640 GRB2 events in ERBB2 signaling 0.274591 0.561
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.285603 0.544
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.087188 1.060
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.087188 1.060
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.087188 1.060
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.087188 1.060
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.087188 1.060
R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.307130 0.513
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.178139 0.749
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.317650 0.498
R-HSA-72165 mRNA Splicing - Minor Pathway 0.200092 0.699
R-HSA-6803529 FGFR2 alternative splicing 0.348266 0.458
R-HSA-8957275 Post-translational protein phosphorylation 0.233308 0.632
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.306626 0.513
R-HSA-8854518 AURKA Activation by TPX2 0.312221 0.506
R-HSA-167172 Transcription of the HIV genome 0.111753 0.952
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.090318 1.044
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.334495 0.476
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.278546 0.555
R-HSA-72086 mRNA Capping 0.100739 0.997
R-HSA-202433 Generation of second messenger molecules 0.161942 0.791
R-HSA-5654710 PI-3K cascade:FGFR3 0.307130 0.513
R-HSA-5654720 PI-3K cascade:FGFR4 0.317650 0.498
R-HSA-5654689 PI-3K cascade:FGFR1 0.348266 0.458
R-HSA-373753 Nephrin family interactions 0.317650 0.498
R-HSA-140342 Apoptosis induced DNA fragmentation 0.180185 0.744
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.178625 0.748
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.131705 0.880
R-HSA-191650 Regulation of gap junction activity 0.087600 1.057
R-HSA-8951936 RUNX3 regulates p14-ARF 0.216942 0.664
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.345556 0.461
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.225302 0.647
R-HSA-190373 FGFR1c ligand binding and activation 0.228825 0.640
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.105555 0.977
R-HSA-190239 FGFR3 ligand binding and activation 0.252057 0.599
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.285603 0.544
R-HSA-162599 Late Phase of HIV Life Cycle 0.100496 0.998
R-HSA-5619507 Activation of HOX genes during differentiation 0.261696 0.582
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.261696 0.582
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.340264 0.468
R-HSA-5655332 Signaling by FGFR3 in disease 0.091304 1.040
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.120356 0.920
R-HSA-2871796 FCERI mediated MAPK activation 0.123595 0.908
R-HSA-8856828 Clathrin-mediated endocytosis 0.102472 0.989
R-HSA-446728 Cell junction organization 0.173954 0.760
R-HSA-9639288 Amino acids regulate mTORC1 0.239152 0.621
R-HSA-1500931 Cell-Cell communication 0.145449 0.837
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.204876 0.689
R-HSA-190242 FGFR1 ligand binding and activation 0.296449 0.528
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.167311 0.776
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.317650 0.498
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.239152 0.621
R-HSA-74751 Insulin receptor signalling cascade 0.099160 1.004
R-HSA-201451 Signaling by BMP 0.091304 1.040
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.087600 1.057
R-HSA-68689 CDC6 association with the ORC:origin complex 0.115067 0.939
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.154731 0.810
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.180185 0.744
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.192624 0.715
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.204876 0.689
R-HSA-428540 Activation of RAC1 0.204876 0.689
R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.204876 0.689
R-HSA-8866427 VLDLR internalisation and degradation 0.216942 0.664
R-HSA-190322 FGFR4 ligand binding and activation 0.228825 0.640
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.100739 0.997
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.263409 0.579
R-HSA-432720 Lysosome Vesicle Biogenesis 0.140812 0.851
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.296449 0.528
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.307130 0.513
R-HSA-168325 Viral Messenger RNA Synthesis 0.284172 0.546
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.307059 0.513
R-HSA-9711097 Cellular response to starvation 0.134344 0.872
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.136888 0.864
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.216942 0.664
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.130490 0.884
R-HSA-500753 Pyrimidine biosynthesis 0.307130 0.513
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.317650 0.498
R-HSA-162587 HIV Life Cycle 0.132093 0.879
R-HSA-9824272 Somitogenesis 0.194572 0.711
R-HSA-418885 DCC mediated attractive signaling 0.252057 0.599
R-HSA-8875878 MET promotes cell motility 0.151303 0.820
R-HSA-1226099 Signaling by FGFR in disease 0.131705 0.880
R-HSA-74752 Signaling by Insulin receptor 0.205542 0.687
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.154731 0.810
R-HSA-450341 Activation of the AP-1 family of transcription factors 0.167555 0.776
R-HSA-9761174 Formation of intermediate mesoderm 0.180185 0.744
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.263409 0.579
R-HSA-190241 FGFR2 ligand binding and activation 0.328012 0.484
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.348266 0.458
R-HSA-5658442 Regulation of RAS by GAPs 0.222340 0.653
R-HSA-157118 Signaling by NOTCH 0.209191 0.679
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.338216 0.471
R-HSA-193697 p75NTR regulates axonogenesis 0.167555 0.776
R-HSA-8853659 RET signaling 0.140812 0.851
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.257611 0.589
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.323381 0.490
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.272928 0.564
R-HSA-5655302 Signaling by FGFR1 in disease 0.172711 0.763
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.115067 0.939
R-HSA-2179392 EGFR Transactivation by Gastrin 0.180185 0.744
R-HSA-1839130 Signaling by activated point mutants of FGFR3 0.228825 0.640
R-HSA-9754706 Atorvastatin ADME 0.263409 0.579
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.296449 0.528
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.328012 0.484
R-HSA-112409 RAF-independent MAPK1/3 activation 0.348266 0.458
R-HSA-112399 IRS-mediated signalling 0.261654 0.582
R-HSA-162906 HIV Infection 0.326632 0.486
R-HSA-2033519 Activated point mutants of FGFR2 0.296449 0.528
R-HSA-157858 Gap junction trafficking and regulation 0.216757 0.664
R-HSA-8934903 Receptor Mediated Mitophagy 0.180185 0.744
R-HSA-1643713 Signaling by EGFR in Cancer 0.086690 1.062
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 0.216942 0.664
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.252057 0.599
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.252057 0.599
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.274591 0.561
R-HSA-3214841 PKMTs methylate histone lysines 0.167311 0.776
R-HSA-199991 Membrane Trafficking 0.090883 1.042
R-HSA-114452 Activation of BH3-only proteins 0.105555 0.977
R-HSA-8878159 Transcriptional regulation by RUNX3 0.229298 0.640
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.167555 0.776
R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.228825 0.640
R-HSA-113510 E2F mediated regulation of DNA replication 0.307130 0.513
R-HSA-166208 mTORC1-mediated signalling 0.348266 0.458
R-HSA-3371571 HSF1-dependent transactivation 0.227935 0.642
R-HSA-2428928 IRS-related events triggered by IGF1R 0.284172 0.546
R-HSA-451927 Interleukin-2 family signaling 0.161942 0.791
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.267285 0.573
R-HSA-5653656 Vesicle-mediated transport 0.287532 0.541
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.216942 0.664
R-HSA-9733709 Cardiogenesis 0.120356 0.920
R-HSA-1839126 FGFR2 mutant receptor activation 0.140812 0.851
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.307130 0.513
R-HSA-8863795 Downregulation of ERBB2 signaling 0.105555 0.977
R-HSA-983189 Kinesins 0.278546 0.555
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.101438 0.994
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.115067 0.939
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.115067 0.939
R-HSA-2033514 FGFR3 mutant receptor activation 0.228825 0.640
R-HSA-3214847 HATs acetylate histones 0.089617 1.048
R-HSA-8939211 ESR-mediated signaling 0.202096 0.694
R-HSA-162582 Signal Transduction 0.075601 1.121
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.274591 0.561
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 0.348266 0.458
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.289795 0.538
R-HSA-69275 G2/M Transition 0.206355 0.685
R-HSA-9909396 Circadian clock 0.192072 0.717
R-HSA-453274 Mitotic G2-G2/M phases 0.211738 0.674
R-HSA-74160 Gene expression (Transcription) 0.120239 0.920
R-HSA-1483249 Inositol phosphate metabolism 0.294631 0.531
R-HSA-354192 Integrin signaling 0.120356 0.920
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.120356 0.920
R-HSA-9675151 Disorders of Developmental Biology 0.274591 0.561
R-HSA-9671555 Signaling by PDGFR in disease 0.338216 0.471
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.278546 0.555
R-HSA-177929 Signaling by EGFR 0.075880 1.120
R-HSA-114604 GPVI-mediated activation cascade 0.140812 0.851
R-HSA-3928662 EPHB-mediated forward signaling 0.189071 0.723
R-HSA-168255 Influenza Infection 0.187890 0.726
R-HSA-8878171 Transcriptional regulation by RUNX1 0.176889 0.752
R-HSA-8964038 LDL clearance 0.348266 0.458
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.194572 0.711
R-HSA-422475 Axon guidance 0.160338 0.795
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.252057 0.599
R-HSA-9027307 Biosynthesis of maresin-like SPMs 0.274591 0.561
R-HSA-392517 Rap1 signalling 0.307130 0.513
R-HSA-8854214 TBC/RABGAPs 0.183593 0.736
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.348266 0.458
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.323381 0.490
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.344577 0.463
R-HSA-3371556 Cellular response to heat stress 0.153562 0.814
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.121577 0.915
R-HSA-109581 Apoptosis 0.143516 0.843
R-HSA-9675108 Nervous system development 0.214515 0.669
R-HSA-5655291 Signaling by FGFR4 in disease 0.240529 0.619
R-HSA-156711 Polo-like kinase mediated events 0.296449 0.528
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.257611 0.589
R-HSA-376176 Signaling by ROBO receptors 0.253435 0.596
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.240529 0.619
R-HSA-1433559 Regulation of KIT signaling 0.240529 0.619
R-HSA-8941326 RUNX2 regulates bone development 0.140812 0.851
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.256023 0.592
R-HSA-373755 Semaphorin interactions 0.295412 0.530
R-HSA-9819196 Zygotic genome activation (ZGA) 0.328012 0.484
R-HSA-8963896 HDL assembly 0.240529 0.619
R-HSA-416700 Other semaphorin interactions 0.252057 0.599
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.256023 0.592
R-HSA-9031628 NGF-stimulated transcription 0.211187 0.675
R-HSA-2682334 EPH-Ephrin signaling 0.205542 0.687
R-HSA-6807070 PTEN Regulation 0.217136 0.663
R-HSA-9614085 FOXO-mediated transcription 0.237331 0.625
R-HSA-3247509 Chromatin modifying enzymes 0.195092 0.710
R-HSA-9020558 Interleukin-2 signaling 0.192624 0.715
R-HSA-9762292 Regulation of CDH11 function 0.180185 0.744
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.228825 0.640
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.135629 0.868
R-HSA-5620916 VxPx cargo-targeting to cilium 0.317650 0.498
R-HSA-5357801 Programmed Cell Death 0.262016 0.582
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.078643 1.104
R-HSA-450294 MAP kinase activation 0.284172 0.546
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.252057 0.599
R-HSA-445144 Signal transduction by L1 0.317650 0.498
R-HSA-8878166 Transcriptional regulation by RUNX2 0.331963 0.479
R-HSA-75893 TNF signaling 0.256023 0.592
R-HSA-448424 Interleukin-17 signaling 0.334495 0.476
R-HSA-4839726 Chromatin organization 0.230985 0.636
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.345556 0.461
R-HSA-9012852 Signaling by NOTCH3 0.073162 1.136
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.091304 1.040
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.086690 1.062
R-HSA-9669938 Signaling by KIT in disease 0.348266 0.458
R-HSA-69205 G1/S-Specific Transcription 0.140812 0.851
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.340032 0.468
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.211187 0.675
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.120356 0.920
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.115366 0.938
R-HSA-9009391 Extra-nuclear estrogen signaling 0.245411 0.610
R-HSA-5210891 Uptake and function of anthrax toxins 0.285603 0.544
R-HSA-9013694 Signaling by NOTCH4 0.131705 0.880
R-HSA-5357905 Regulation of TNFR1 signaling 0.200092 0.699
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.311207 0.507
R-HSA-449147 Signaling by Interleukins 0.285756 0.544
R-HSA-186712 Regulation of beta-cell development 0.084297 1.074
R-HSA-9694635 Translation of Structural Proteins 0.142117 0.847
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.205542 0.687
R-HSA-2132295 MHC class II antigen presentation 0.348558 0.458
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.348558 0.458
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.351064 0.455
R-HSA-69052 Switching of origins to a post-replicative state 0.351064 0.455
R-HSA-1236394 Signaling by ERBB4 0.356556 0.448
R-HSA-9018682 Biosynthesis of maresins 0.358164 0.446
R-HSA-9830674 Formation of the ureteric bud 0.358164 0.446
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.360978 0.443
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.360978 0.443
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.360978 0.443
R-HSA-1169408 ISG15 antiviral mechanism 0.362032 0.441
R-HSA-429947 Deadenylation of mRNA 0.367912 0.434
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.367912 0.434
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.367912 0.434
R-HSA-8963898 Plasma lipoprotein assembly 0.367912 0.434
R-HSA-5654695 PI-3K cascade:FGFR2 0.377513 0.423
R-HSA-420029 Tight junction interactions 0.377513 0.423
R-HSA-400685 Sema4D in semaphorin signaling 0.377513 0.423
R-HSA-9839394 TGFBR3 expression 0.377513 0.423
R-HSA-4086400 PCP/CE pathway 0.378352 0.422
R-HSA-9659379 Sensory processing of sound 0.383754 0.416
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.386969 0.412
R-HSA-5689901 Metalloprotease DUBs 0.386969 0.412
R-HSA-70635 Urea cycle 0.386969 0.412
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.386969 0.412
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.386969 0.412
R-HSA-9843745 Adipogenesis 0.389805 0.409
R-HSA-8856688 Golgi-to-ER retrograde transport 0.393899 0.405
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.394496 0.404
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.396281 0.402
R-HSA-3928663 EPHA-mediated growth cone collapse 0.396281 0.402
R-HSA-421270 Cell-cell junction organization 0.398715 0.399
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.399836 0.398
R-HSA-9707564 Cytoprotection by HMOX1 0.405153 0.392
R-HSA-5654732 Negative regulation of FGFR3 signaling 0.405453 0.392
R-HSA-9757110 Prednisone ADME 0.405453 0.392
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.405453 0.392
R-HSA-9018519 Estrogen-dependent gene expression 0.414259 0.383
R-HSA-5654733 Negative regulation of FGFR4 signaling 0.414486 0.382
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.414486 0.382
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.414486 0.382
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.414486 0.382
R-HSA-6802957 Oncogenic MAPK signaling 0.415720 0.381
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.416652 0.380
R-HSA-2262752 Cellular responses to stress 0.420918 0.376
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.423382 0.373
R-HSA-68962 Activation of the pre-replicative complex 0.423382 0.373
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.423382 0.373
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.423382 0.373
R-HSA-381038 XBP1(S) activates chaperone genes 0.426193 0.370
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.430230 0.366
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.432144 0.364
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.432144 0.364
R-HSA-162588 Budding and maturation of HIV virion 0.432144 0.364
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.432144 0.364
R-HSA-5694530 Cargo concentration in the ER 0.432144 0.364
R-HSA-9833109 Evasion by RSV of host interferon responses 0.432144 0.364
R-HSA-182971 EGFR downregulation 0.432144 0.364
R-HSA-156902 Peptide chain elongation 0.436567 0.360
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.440359 0.356
R-HSA-9675126 Diseases of mitotic cell cycle 0.440773 0.356
R-HSA-1855170 IPs transport between nucleus and cytosol 0.449271 0.347
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.449271 0.347
R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.449271 0.347
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.449271 0.347
R-HSA-176187 Activation of ATR in response to replication stress 0.449271 0.347
R-HSA-5654726 Negative regulation of FGFR1 signaling 0.449271 0.347
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.449271 0.347
R-HSA-1839124 FGFR1 mutant receptor activation 0.449271 0.347
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.449271 0.347
R-HSA-9711123 Cellular response to chemical stress 0.449444 0.347
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.451936 0.345
R-HSA-8986944 Transcriptional Regulation by MECP2 0.451936 0.345
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.457006 0.340
R-HSA-381070 IRE1alpha activates chaperones 0.457006 0.340
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.457641 0.339
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.457641 0.339
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.457641 0.339
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.457641 0.339
R-HSA-5693537 Resolution of D-Loop Structures 0.457641 0.339
R-HSA-156842 Eukaryotic Translation Elongation 0.462049 0.335
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.462049 0.335
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.465884 0.332
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 0.465884 0.332
R-HSA-180746 Nuclear import of Rev protein 0.465884 0.332
R-HSA-5654727 Negative regulation of FGFR2 signaling 0.465884 0.332
R-HSA-1980145 Signaling by NOTCH2 0.465884 0.332
R-HSA-5205647 Mitophagy 0.465884 0.332
R-HSA-5673000 RAF activation 0.465884 0.332
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.465884 0.332
R-HSA-68867 Assembly of the pre-replicative complex 0.467065 0.331
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.474002 0.324
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.474002 0.324
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.477013 0.321
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.477754 0.321
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.481621 0.317
R-HSA-72689 Formation of a pool of free 40S subunits 0.481945 0.317
R-HSA-72764 Eukaryotic Translation Termination 0.481945 0.317
R-HSA-212300 PRC2 methylates histones and DNA 0.481997 0.317
R-HSA-9682385 FLT3 signaling in disease 0.481997 0.317
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.486848 0.313
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.486848 0.313
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.489314 0.310
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.489872 0.310
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.489872 0.310
R-HSA-933541 TRAF6 mediated IRF7 activation 0.489872 0.310
R-HSA-5689896 Ovarian tumor domain proteases 0.489872 0.310
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.489872 0.310
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.489872 0.310
R-HSA-418990 Adherens junctions interactions 0.493376 0.307
R-HSA-9694516 SARS-CoV-2 Infection 0.495668 0.305
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.496567 0.304
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.496567 0.304
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.496567 0.304
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.497627 0.303
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.505264 0.296
R-HSA-8953750 Transcriptional Regulation by E2F6 0.505264 0.296
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.505264 0.296
R-HSA-8964043 Plasma lipoprotein clearance 0.505264 0.296
R-HSA-70171 Glycolysis 0.506169 0.296
R-HSA-2408557 Selenocysteine synthesis 0.510926 0.292
R-HSA-5633007 Regulation of TP53 Activity 0.512052 0.291
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.512786 0.290
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.512786 0.290
R-HSA-177243 Interactions of Rev with host cellular proteins 0.512786 0.290
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.512786 0.290
R-HSA-3371568 Attenuation phase 0.512786 0.290
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.512786 0.290
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.512786 0.290
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.512786 0.290
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.515652 0.288
R-HSA-1483255 PI Metabolism 0.515652 0.288
R-HSA-9679506 SARS-CoV Infections 0.519592 0.284
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.520195 0.284
R-HSA-5423646 Aflatoxin activation and detoxification 0.520195 0.284
R-HSA-8853884 Transcriptional Regulation by VENTX 0.520195 0.284
R-HSA-9607240 FLT3 Signaling 0.520195 0.284
R-HSA-192823 Viral mRNA Translation 0.520348 0.284
R-HSA-1257604 PIP3 activates AKT signaling 0.527408 0.278
R-HSA-5674135 MAP2K and MAPK activation 0.527490 0.278
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.527490 0.278
R-HSA-167161 HIV Transcription Initiation 0.527490 0.278
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.527490 0.278
R-HSA-9656223 Signaling by RAF1 mutants 0.527490 0.278
R-HSA-6811438 Intra-Golgi traffic 0.527490 0.278
R-HSA-5675221 Negative regulation of MAPK pathway 0.527490 0.278
R-HSA-9006931 Signaling by Nuclear Receptors 0.531779 0.274
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.534253 0.272
R-HSA-165159 MTOR signalling 0.534676 0.272
R-HSA-9692914 SARS-CoV-1-host interactions 0.538827 0.269
R-HSA-73776 RNA Polymerase II Promoter Escape 0.541753 0.266
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.541753 0.266
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.541753 0.266
R-HSA-1433557 Signaling by SCF-KIT 0.541753 0.266
R-HSA-69278 Cell Cycle, Mitotic 0.542425 0.266
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.543370 0.265
R-HSA-69239 Synthesis of DNA 0.543370 0.265
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.547881 0.261
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.547881 0.261
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.547881 0.261
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.547881 0.261
R-HSA-8953854 Metabolism of RNA 0.548543 0.261
R-HSA-190828 Gap junction trafficking 0.548722 0.261
R-HSA-373752 Netrin-1 signaling 0.548722 0.261
R-HSA-5683826 Surfactant metabolism 0.548722 0.261
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.548722 0.261
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.552307 0.258
R-HSA-69002 DNA Replication Pre-Initiation 0.552362 0.258
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.552362 0.258
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.555586 0.255
R-HSA-774815 Nucleosome assembly 0.555586 0.255
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.555586 0.255
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.555586 0.255
R-HSA-4608870 Asymmetric localization of PCP proteins 0.555586 0.255
R-HSA-6783310 Fanconi Anemia Pathway 0.555586 0.255
R-HSA-418555 G alpha (s) signalling events 0.555869 0.255
R-HSA-202403 TCR signaling 0.556811 0.254
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.556811 0.254
R-HSA-166166 MyD88-independent TLR4 cascade 0.556811 0.254
R-HSA-388396 GPCR downstream signalling 0.558162 0.253
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.562346 0.250
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.562346 0.250
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.562346 0.250
R-HSA-9649948 Signaling downstream of RAS mutants 0.562346 0.250
R-HSA-6802949 Signaling by RAS mutants 0.562346 0.250
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.562346 0.250
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.562346 0.250
R-HSA-9839373 Signaling by TGFBR3 0.562346 0.250
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.562942 0.250
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.562942 0.250
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.565616 0.247
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.565616 0.247
R-HSA-437239 Recycling pathway of L1 0.569003 0.245
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.569003 0.245
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.569970 0.244
R-HSA-70263 Gluconeogenesis 0.575560 0.240
R-HSA-9766229 Degradation of CDH1 0.582017 0.235
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.582846 0.234
R-HSA-109704 PI3K Cascade 0.588376 0.230
R-HSA-72613 Eukaryotic Translation Initiation 0.591271 0.228
R-HSA-72737 Cap-dependent Translation Initiation 0.591271 0.228
R-HSA-373760 L1CAM interactions 0.591271 0.228
R-HSA-9864848 Complex IV assembly 0.594639 0.226
R-HSA-5358346 Hedgehog ligand biogenesis 0.594639 0.226
R-HSA-1852241 Organelle biogenesis and maintenance 0.595020 0.225
R-HSA-70326 Glucose metabolism 0.595436 0.225
R-HSA-9007101 Rab regulation of trafficking 0.595436 0.225
R-HSA-1592230 Mitochondrial biogenesis 0.595436 0.225
R-HSA-68949 Orc1 removal from chromatin 0.600807 0.221
R-HSA-72187 mRNA 3'-end processing 0.600807 0.221
R-HSA-5339562 Uptake and actions of bacterial toxins 0.600807 0.221
R-HSA-212165 Epigenetic regulation of gene expression 0.602771 0.220
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.603671 0.219
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.603671 0.219
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.606882 0.217
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.606882 0.217
R-HSA-445355 Smooth Muscle Contraction 0.606882 0.217
R-HSA-8956320 Nucleotide biosynthesis 0.606882 0.217
R-HSA-72649 Translation initiation complex formation 0.612865 0.213
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.612865 0.213
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.612865 0.213
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.613758 0.212
R-HSA-8953897 Cellular responses to stimuli 0.614409 0.212
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.615786 0.211
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.615786 0.211
R-HSA-5617833 Cilium Assembly 0.620227 0.207
R-HSA-168898 Toll-like Receptor Cascades 0.623434 0.205
R-HSA-72702 Ribosomal scanning and start codon recognition 0.624559 0.204
R-HSA-9764561 Regulation of CDH1 Function 0.630274 0.200
R-HSA-2980766 Nuclear Envelope Breakdown 0.630274 0.200
R-HSA-69206 G1/S Transition 0.631497 0.200
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.635902 0.197
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.635902 0.197
R-HSA-191859 snRNP Assembly 0.641444 0.193
R-HSA-194441 Metabolism of non-coding RNA 0.641444 0.193
R-HSA-429914 Deadenylation-dependent mRNA decay 0.641444 0.193
R-HSA-9006925 Intracellular signaling by second messengers 0.649851 0.187
R-HSA-73856 RNA Polymerase II Transcription Termination 0.652279 0.186
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.652279 0.186
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.657573 0.182
R-HSA-6784531 tRNA processing in the nucleus 0.657573 0.182
R-HSA-375165 NCAM signaling for neurite out-growth 0.657573 0.182
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.657573 0.182
R-HSA-76002 Platelet activation, signaling and aggregation 0.658566 0.181
R-HSA-1474228 Degradation of the extracellular matrix 0.661412 0.180
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.662787 0.179
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.662787 0.179
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.662787 0.179
R-HSA-211981 Xenobiotics 0.667922 0.175
R-HSA-1234174 Cellular response to hypoxia 0.672979 0.172
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.677960 0.169
R-HSA-3858494 Beta-catenin independent WNT signaling 0.679104 0.168
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.682864 0.166
R-HSA-9830369 Kidney development 0.682864 0.166
R-HSA-9824446 Viral Infection Pathways 0.683618 0.165
R-HSA-9948299 Ribosome-associated quality control 0.685967 0.164
R-HSA-381119 Unfolded Protein Response (UPR) 0.689354 0.162
R-HSA-9730414 MITF-M-regulated melanocyte development 0.692059 0.160
R-HSA-372790 Signaling by GPCR 0.693794 0.159
R-HSA-1632852 Macroautophagy 0.696037 0.157
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.697137 0.157
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.697137 0.157
R-HSA-453276 Regulation of mitotic cell cycle 0.701751 0.154
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.701751 0.154
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.701751 0.154
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.701751 0.154
R-HSA-5578749 Transcriptional regulation by small RNAs 0.706295 0.151
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.706295 0.151
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.710770 0.148
R-HSA-9749641 Aspirin ADME 0.710770 0.148
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.715378 0.145
R-HSA-195721 Signaling by WNT 0.717218 0.144
R-HSA-199977 ER to Golgi Anterograde Transport 0.718500 0.144
R-HSA-380287 Centrosome maturation 0.719517 0.143
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.719517 0.143
R-HSA-69242 S Phase 0.721592 0.142
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.721592 0.142
R-HSA-9679191 Potential therapeutics for SARS 0.727692 0.138
R-HSA-9856651 MITF-M-dependent gene expression 0.727692 0.138
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.728000 0.138
R-HSA-9705683 SARS-CoV-2-host interactions 0.731511 0.136
R-HSA-216083 Integrin cell surface interactions 0.732146 0.135
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.736229 0.133
R-HSA-69306 DNA Replication 0.736631 0.133
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.739554 0.131
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.740249 0.131
R-HSA-72312 rRNA processing 0.741338 0.130
R-HSA-1989781 PPARA activates gene expression 0.742450 0.129
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 0.744209 0.128
R-HSA-9612973 Autophagy 0.745319 0.128
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.748108 0.126
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.748160 0.126
R-HSA-202733 Cell surface interactions at the vascular wall 0.753220 0.123
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.755730 0.122
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.755730 0.122
R-HSA-5687128 MAPK6/MAPK4 signaling 0.759455 0.119
R-HSA-141424 Amplification of signal from the kinetochores 0.763123 0.117
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.763123 0.117
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.763123 0.117
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.766735 0.115
R-HSA-2408522 Selenoamino acid metabolism 0.767297 0.115
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.773796 0.111
R-HSA-9663891 Selective autophagy 0.773796 0.111
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.780644 0.108
R-HSA-112310 Neurotransmitter release cycle 0.780644 0.108
R-HSA-1640170 Cell Cycle 0.786127 0.105
R-HSA-1280215 Cytokine Signaling in Immune system 0.789827 0.102
R-HSA-5688426 Deubiquitination 0.792406 0.101
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.793726 0.100
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.796873 0.099
R-HSA-9678108 SARS-CoV-1 Infection 0.797177 0.098
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.799973 0.097
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.803025 0.095
R-HSA-6807878 COPI-mediated anterograde transport 0.806031 0.094
R-HSA-2559583 Cellular Senescence 0.808595 0.092
R-HSA-416476 G alpha (q) signalling events 0.809984 0.092
R-HSA-1266738 Developmental Biology 0.811584 0.091
R-HSA-201681 TCF dependent signaling in response to WNT 0.815169 0.089
R-HSA-69618 Mitotic Spindle Checkpoint 0.817605 0.087
R-HSA-9020702 Interleukin-1 signaling 0.820389 0.086
R-HSA-9842860 Regulation of endogenous retroelements 0.823131 0.085
R-HSA-2559580 Oxidative Stress Induced Senescence 0.823131 0.085
R-HSA-9833110 RSV-host interactions 0.831110 0.080
R-HSA-1280218 Adaptive Immune System 0.834959 0.078
R-HSA-68877 Mitotic Prometaphase 0.835652 0.078
R-HSA-211000 Gene Silencing by RNA 0.838730 0.076
R-HSA-2672351 Stimuli-sensing channels 0.841193 0.075
R-HSA-9609690 HCMV Early Events 0.841387 0.075
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.841398 0.075
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.843618 0.074
R-HSA-428157 Sphingolipid metabolism 0.850543 0.070
R-HSA-948021 Transport to the Golgi and subsequent modification 0.852316 0.069
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.855204 0.068
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.861741 0.065
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.867984 0.061
R-HSA-5693538 Homology Directed Repair 0.867984 0.061
R-HSA-109582 Hemostasis 0.869989 0.060
R-HSA-68875 Mitotic Prophase 0.871989 0.059
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.873946 0.059
R-HSA-73886 Chromosome Maintenance 0.873946 0.059
R-HSA-68882 Mitotic Anaphase 0.876707 0.057
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.877771 0.057
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.878193 0.056
R-HSA-6809371 Formation of the cornified envelope 0.879640 0.056
R-HSA-162909 Host Interactions of HIV factors 0.879640 0.056
R-HSA-194138 Signaling by VEGF 0.883292 0.054
R-HSA-69481 G2/M Checkpoints 0.886835 0.052
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.891949 0.050
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.894792 0.048
R-HSA-1474244 Extracellular matrix organization 0.905196 0.043
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.905950 0.043
R-HSA-5358351 Signaling by Hedgehog 0.907389 0.042
R-HSA-9664417 Leishmania phagocytosis 0.910203 0.041
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.910203 0.041
R-HSA-9664407 Parasite infection 0.910203 0.041
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.911578 0.040
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.914265 0.039
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 0.915577 0.038
R-HSA-9609646 HCMV Infection 0.918891 0.037
R-HSA-69620 Cell Cycle Checkpoints 0.926630 0.033
R-HSA-9609507 Protein localization 0.927653 0.033
R-HSA-5693532 DNA Double-Strand Break Repair 0.927653 0.033
R-HSA-9734767 Developmental Cell Lineages 0.931108 0.031
R-HSA-9610379 HCMV Late Events 0.931986 0.031
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.933029 0.030
R-HSA-2467813 Separation of Sister Chromatids 0.938957 0.027
R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.941723 0.026
R-HSA-5619102 SLC transporter disorders 0.941723 0.026
R-HSA-72306 tRNA processing 0.945216 0.024
R-HSA-5621481 C-type lectin receptors (CLRs) 0.946057 0.024
R-HSA-68886 M Phase 0.946748 0.024
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.946884 0.024
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.947350 0.023
R-HSA-5689880 Ub-specific processing proteases 0.947699 0.023
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.948502 0.023
R-HSA-5663205 Infectious disease 0.948682 0.023
R-HSA-611105 Respiratory electron transport 0.951591 0.022
R-HSA-1483257 Phospholipid metabolism 0.954201 0.020
R-HSA-3781865 Diseases of glycosylation 0.955881 0.020
R-HSA-1643685 Disease 0.957679 0.019
R-HSA-983712 Ion channel transport 0.959166 0.018
R-HSA-389948 Co-inhibition by PD-1 0.965560 0.015
R-HSA-6805567 Keratinization 0.969099 0.014
R-HSA-397014 Muscle contraction 0.971843 0.012
R-HSA-168256 Immune System 0.973486 0.012
R-HSA-9748784 Drug ADME 0.974344 0.011
R-HSA-15869 Metabolism of nucleotides 0.980595 0.009
R-HSA-5619115 Disorders of transmembrane transporters 0.983642 0.007
R-HSA-388841 Regulation of T cell activation by CD28 family 0.985777 0.006
R-HSA-913531 Interferon Signaling 0.985856 0.006
R-HSA-9824439 Bacterial Infection Pathways 0.987131 0.006
R-HSA-211945 Phase I - Functionalization of compounds 0.989899 0.004
R-HSA-9658195 Leishmania infection 0.990360 0.004
R-HSA-9824443 Parasitic Infection Pathways 0.990360 0.004
R-HSA-446203 Asparagine N-linked glycosylation 0.991672 0.004
R-HSA-72766 Translation 0.992433 0.003
R-HSA-168249 Innate Immune System 0.994078 0.003
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.994711 0.002
R-HSA-6798695 Neutrophil degranulation 0.994855 0.002
R-HSA-112315 Transmission across Chemical Synapses 0.994991 0.002
R-HSA-8957322 Metabolism of steroids 0.995069 0.002
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.996218 0.002
R-HSA-71291 Metabolism of amino acids and derivatives 0.997043 0.001
R-HSA-73894 DNA Repair 0.997190 0.001
R-HSA-5668914 Diseases of metabolism 0.999033 0.000
R-HSA-112316 Neuronal System 0.999493 0.000
R-HSA-597592 Post-translational protein modification 0.999780 0.000
R-HSA-211859 Biological oxidations 0.999787 0.000
R-HSA-382551 Transport of small molecules 0.999979 0.000
R-HSA-556833 Metabolism of lipids 0.999986 0.000
R-HSA-9752946 Expression and translocation of olfactory receptors 0.999997 0.000
R-HSA-392499 Metabolism of proteins 0.999999 0.000
R-HSA-381753 Olfactory Signaling Pathway 0.999999 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.868 0.411 1 0.809
SRPK1SRPK1 0.867 0.497 -3 0.917
RSK2RSK2 0.867 0.510 -3 0.921
PIM3PIM3 0.866 0.494 -3 0.914
PRKD2PRKD2 0.864 0.490 -3 0.899
HIPK4HIPK4 0.863 0.461 1 0.799
PRKD1PRKD1 0.862 0.469 -3 0.889
NDR2NDR2 0.861 0.391 -3 0.888
P90RSKP90RSK 0.860 0.501 -3 0.921
PIM1PIM1 0.859 0.500 -3 0.911
MAPKAPK2MAPKAPK2 0.859 0.471 -3 0.899
CDKL5CDKL5 0.858 0.482 -3 0.916
SRPK2SRPK2 0.858 0.483 -3 0.890
RSK4RSK4 0.858 0.501 -3 0.924
CDKL1CDKL1 0.857 0.503 -3 0.910
RSK3RSK3 0.856 0.456 -3 0.909
CLK2CLK2 0.856 0.476 -3 0.911
PKACBPKACB 0.855 0.424 -2 0.689
AURCAURC 0.855 0.320 -2 0.687
PRKXPRKX 0.854 0.454 -3 0.876
COTCOT 0.854 0.165 2 0.762
SKMLCKSKMLCK 0.852 0.405 -2 0.866
NDR1NDR1 0.852 0.359 -3 0.888
MAPKAPK3MAPKAPK3 0.851 0.433 -3 0.881
ICKICK 0.850 0.450 -3 0.913
PKACGPKACG 0.848 0.343 -2 0.747
MSK1MSK1 0.847 0.430 -3 0.895
SRPK3SRPK3 0.847 0.428 -3 0.889
CAMK1BCAMK1B 0.847 0.396 -3 0.877
LATS2LATS2 0.847 0.291 -5 0.720
CLK4CLK4 0.846 0.418 -3 0.903
HIPK2HIPK2 0.846 0.336 1 0.614
AKT2AKT2 0.846 0.478 -3 0.890
PRKD3PRKD3 0.846 0.446 -3 0.886
MSK2MSK2 0.845 0.418 -3 0.901
P70S6KBP70S6KB 0.845 0.394 -3 0.893
MOSMOS 0.844 0.219 1 0.843
CDC7CDC7 0.844 0.143 1 0.809
CAMK2ACAMK2A 0.844 0.362 2 0.765
DYRK2DYRK2 0.843 0.290 1 0.705
HIPK1HIPK1 0.843 0.374 1 0.723
NUAK2NUAK2 0.843 0.343 -3 0.898
CLK1CLK1 0.843 0.411 -3 0.890
PIM2PIM2 0.842 0.472 -3 0.898
PKN3PKN3 0.842 0.313 -3 0.877
GRK1GRK1 0.841 0.220 -2 0.824
CAMK2DCAMK2D 0.841 0.287 -3 0.850
IKKBIKKB 0.840 0.060 -2 0.738
CAMLCKCAMLCK 0.840 0.347 -2 0.848
AMPKA2AMPKA2 0.839 0.363 -3 0.882
AMPKA1AMPKA1 0.839 0.324 -3 0.873
PAK1PAK1 0.839 0.270 -2 0.809
NLKNLK 0.838 0.130 1 0.822
MAKMAK 0.838 0.466 -2 0.799
PKN2PKN2 0.838 0.269 -3 0.850
LATS1LATS1 0.838 0.378 -3 0.889
PKACAPKACA 0.838 0.395 -2 0.647
ERK5ERK5 0.837 0.150 1 0.844
PKCDPKCD 0.837 0.266 2 0.689
DAPK2DAPK2 0.837 0.389 -3 0.867
CAMK2BCAMK2B 0.837 0.289 2 0.743
AURBAURB 0.836 0.261 -2 0.683
SGK3SGK3 0.836 0.403 -3 0.880
RAF1RAF1 0.836 0.083 1 0.841
MTORMTOR 0.836 0.017 1 0.787
WNK1WNK1 0.836 0.177 -2 0.862
PKG2PKG2 0.835 0.309 -2 0.687
PRPKPRPK 0.835 -0.019 -1 0.861
MST4MST4 0.834 0.140 2 0.782
DYRK1ADYRK1A 0.834 0.370 1 0.725
NIKNIK 0.834 0.286 -3 0.833
MYLK4MYLK4 0.833 0.340 -2 0.797
CHAK2CHAK2 0.833 0.109 -1 0.866
KISKIS 0.833 0.110 1 0.685
AKT1AKT1 0.833 0.427 -3 0.889
TSSK1TSSK1 0.832 0.278 -3 0.878
PAK3PAK3 0.832 0.220 -2 0.804
MARK4MARK4 0.832 0.151 4 0.823
ATRATR 0.831 0.064 1 0.815
AKT3AKT3 0.831 0.464 -3 0.875
MNK2MNK2 0.830 0.212 -2 0.787
DYRK3DYRK3 0.830 0.362 1 0.730
MNK1MNK1 0.830 0.246 -2 0.793
DYRK4DYRK4 0.830 0.247 1 0.617
MELKMELK 0.830 0.316 -3 0.869
RIPK3RIPK3 0.830 0.050 3 0.704
HIPK3HIPK3 0.829 0.322 1 0.727
TBK1TBK1 0.829 -0.029 1 0.751
CAMK2GCAMK2G 0.829 -0.011 2 0.757
SGK1SGK1 0.828 0.482 -3 0.862
PKCBPKCB 0.828 0.224 2 0.634
QSKQSK 0.828 0.261 4 0.795
IKKAIKKA 0.827 0.039 -2 0.721
TSSK2TSSK2 0.827 0.201 -5 0.826
SIKSIK 0.827 0.315 -3 0.867
IKKEIKKE 0.827 -0.043 1 0.750
GCN2GCN2 0.827 -0.143 2 0.723
BRSK1BRSK1 0.826 0.284 -3 0.879
CAMK4CAMK4 0.826 0.222 -3 0.855
PDHK4PDHK4 0.826 -0.192 1 0.849
PAK6PAK6 0.826 0.186 -2 0.738
PKCAPKCA 0.826 0.202 2 0.633
PKCGPKCG 0.826 0.198 2 0.640
NUAK1NUAK1 0.825 0.278 -3 0.883
DCAMKL1DCAMKL1 0.825 0.363 -3 0.885
DYRK1BDYRK1B 0.825 0.260 1 0.646
AURAAURA 0.825 0.213 -2 0.663
BMPR2BMPR2 0.825 -0.138 -2 0.834
PHKG1PHKG1 0.824 0.219 -3 0.872
CAMK1GCAMK1G 0.824 0.347 -3 0.880
MOKMOK 0.824 0.446 1 0.770
P70S6KP70S6K 0.824 0.381 -3 0.869
PAK2PAK2 0.824 0.203 -2 0.794
CAMK1DCAMK1D 0.824 0.422 -3 0.865
DSTYKDSTYK 0.824 -0.104 2 0.793
TGFBR2TGFBR2 0.824 0.014 -2 0.735
PASKPASK 0.822 0.382 -3 0.901
GRK7GRK7 0.822 0.169 1 0.761
GRK5GRK5 0.822 -0.057 -3 0.727
NIM1NIM1 0.822 0.113 3 0.729
CDK7CDK7 0.822 0.087 1 0.655
ULK2ULK2 0.822 -0.168 2 0.680
MLK1MLK1 0.821 -0.073 2 0.716
MAPKAPK5MAPKAPK5 0.821 0.318 -3 0.853
MLK2MLK2 0.820 0.004 2 0.726
SBKSBK 0.820 0.482 -3 0.840
RIPK1RIPK1 0.820 0.043 1 0.830
PDHK1PDHK1 0.819 -0.184 1 0.843
GRK6GRK6 0.819 0.016 1 0.827
CDK18CDK18 0.819 0.099 1 0.591
QIKQIK 0.819 0.155 -3 0.837
MASTLMASTL 0.819 -0.055 -2 0.794
FAM20CFAM20C 0.818 0.071 2 0.613
DLKDLK 0.818 0.031 1 0.830
HUNKHUNK 0.818 -0.049 2 0.705
BMPR1BBMPR1B 0.818 0.099 1 0.786
NEK6NEK6 0.818 -0.086 -2 0.783
BRSK2BRSK2 0.818 0.189 -3 0.851
PKCHPKCH 0.818 0.181 2 0.618
PKCZPKCZ 0.818 0.155 2 0.671
MLK3MLK3 0.818 0.011 2 0.653
WNK3WNK3 0.817 -0.073 1 0.826
MARK3MARK3 0.817 0.168 4 0.756
CHK1CHK1 0.817 0.211 -3 0.851
CDK8CDK8 0.816 0.020 1 0.647
CDK10CDK10 0.816 0.177 1 0.621
JNK2JNK2 0.816 0.086 1 0.603
CHK2CHK2 0.816 0.441 -3 0.856
IRE1IRE1 0.815 0.020 1 0.816
DAPK3DAPK3 0.815 0.380 -3 0.897
BCKDKBCKDK 0.815 -0.125 -1 0.789
MRCKBMRCKB 0.815 0.393 -3 0.870
SMMLCKSMMLCK 0.815 0.323 -3 0.878
CDK19CDK19 0.814 0.039 1 0.608
ROCK2ROCK2 0.814 0.411 -3 0.884
PKRPKR 0.814 0.075 1 0.850
MRCKAMRCKA 0.814 0.385 -3 0.874
MPSK1MPSK1 0.813 0.221 1 0.810
NEK7NEK7 0.813 -0.197 -3 0.716
P38AP38A 0.812 0.078 1 0.713
CDK14CDK14 0.812 0.134 1 0.637
CAMK1ACAMK1A 0.812 0.411 -3 0.859
PKCEPKCE 0.811 0.271 2 0.628
P38BP38B 0.811 0.082 1 0.642
NEK9NEK9 0.811 -0.153 2 0.727
PKCTPKCT 0.811 0.215 2 0.622
CDK1CDK1 0.811 0.051 1 0.614
DCAMKL2DCAMKL2 0.810 0.225 -3 0.883
ANKRD3ANKRD3 0.810 -0.085 1 0.861
JNK3JNK3 0.810 0.052 1 0.637
DAPK1DAPK1 0.810 0.366 -3 0.896
CRIKCRIK 0.810 0.449 -3 0.905
ATMATM 0.810 -0.011 1 0.745
TGFBR1TGFBR1 0.810 0.010 -2 0.751
DMPK1DMPK1 0.810 0.426 -3 0.885
CDK5CDK5 0.810 0.056 1 0.675
TTBK2TTBK2 0.809 -0.111 2 0.593
PAK5PAK5 0.809 0.185 -2 0.686
ALK4ALK4 0.809 -0.017 -2 0.776
ERK1ERK1 0.809 0.057 1 0.628
GRK4GRK4 0.809 -0.104 -2 0.812
IRE2IRE2 0.808 0.002 2 0.642
CDK13CDK13 0.808 0.017 1 0.631
MARK2MARK2 0.808 0.114 4 0.717
SSTKSSTK 0.808 0.167 4 0.768
PKN1PKN1 0.808 0.322 -3 0.871
BUB1BUB1 0.808 0.286 -5 0.781
ULK1ULK1 0.808 -0.228 -3 0.673
DNAPKDNAPK 0.807 0.031 1 0.695
PAK4PAK4 0.807 0.181 -2 0.695
MARK1MARK1 0.807 0.128 4 0.769
SNRKSNRK 0.807 0.067 2 0.595
CHAK1CHAK1 0.807 -0.026 2 0.694
VRK2VRK2 0.806 -0.049 1 0.870
CDK17CDK17 0.806 0.051 1 0.532
MST3MST3 0.805 0.098 2 0.749
YSK4YSK4 0.805 -0.080 1 0.784
PKCIPKCI 0.805 0.166 2 0.643
MLK4MLK4 0.805 -0.071 2 0.628
CDK12CDK12 0.805 0.038 1 0.605
PHKG2PHKG2 0.804 0.174 -3 0.847
MEK1MEK1 0.804 -0.106 2 0.761
CK1ECK1E 0.804 0.014 -3 0.476
DRAK1DRAK1 0.804 0.060 1 0.755
NEK2NEK2 0.804 -0.085 2 0.715
ALK2ALK2 0.803 -0.005 -2 0.767
CDK9CDK9 0.803 0.019 1 0.641
P38GP38G 0.802 0.039 1 0.530
PLK1PLK1 0.802 -0.102 -2 0.723
WNK4WNK4 0.801 0.055 -2 0.843
SMG1SMG1 0.801 -0.065 1 0.767
ERK2ERK2 0.801 0.008 1 0.673
GSK3AGSK3A 0.801 0.097 4 0.531
ACVR2BACVR2B 0.800 -0.031 -2 0.738
TLK2TLK2 0.800 -0.081 1 0.796
ROCK1ROCK1 0.799 0.371 -3 0.869
GSK3BGSK3B 0.799 0.069 4 0.522
GRK2GRK2 0.799 -0.017 -2 0.708
CDK16CDK16 0.799 0.060 1 0.552
IRAK4IRAK4 0.798 0.007 1 0.827
ACVR2AACVR2A 0.798 -0.053 -2 0.723
TAO3TAO3 0.798 0.051 1 0.798
MEK5MEK5 0.797 -0.095 2 0.732
CK1DCK1D 0.797 0.015 -3 0.426
CDK3CDK3 0.797 0.041 1 0.552
PLK3PLK3 0.796 -0.108 2 0.700
PRP4PRP4 0.796 -0.024 -3 0.634
PERKPERK 0.796 -0.109 -2 0.791
BRAFBRAF 0.796 -0.057 -4 0.803
PDK1PDK1 0.795 0.162 1 0.796
P38DP38D 0.795 0.050 1 0.545
LKB1LKB1 0.795 0.059 -3 0.710
GAKGAK 0.795 0.110 1 0.856
PKG1PKG1 0.794 0.270 -2 0.608
BMPR1ABMPR1A 0.794 0.014 1 0.752
GCKGCK 0.794 0.119 1 0.810
NEK5NEK5 0.793 -0.075 1 0.844
PLK4PLK4 0.793 -0.100 2 0.542
CK1A2CK1A2 0.793 -0.002 -3 0.435
MEKK3MEKK3 0.793 -0.120 1 0.811
MEKK1MEKK1 0.793 -0.134 1 0.818
ZAKZAK 0.792 -0.119 1 0.791
MEKK2MEKK2 0.792 -0.091 2 0.700
ERK7ERK7 0.792 0.020 2 0.480
HPK1HPK1 0.791 0.121 1 0.801
CK1G1CK1G1 0.791 -0.042 -3 0.462
TNIKTNIK 0.789 0.082 3 0.822
LOKLOK 0.789 0.079 -2 0.755
PBKPBK 0.789 0.149 1 0.789
PINK1PINK1 0.789 -0.164 1 0.828
KHS1KHS1 0.789 0.145 1 0.801
CAMKK2CAMKK2 0.788 -0.037 -2 0.762
HRIHRI 0.788 -0.198 -2 0.790
GRK3GRK3 0.787 -0.014 -2 0.671
KHS2KHS2 0.787 0.150 1 0.809
TLK1TLK1 0.787 -0.133 -2 0.778
MAP3K15MAP3K15 0.786 0.024 1 0.777
HGKHGK 0.786 0.024 3 0.824
CDK2CDK2 0.786 -0.076 1 0.697
CAMKK1CAMKK1 0.786 -0.127 -2 0.755
TAO2TAO2 0.786 -0.029 2 0.747
MEKK6MEKK6 0.786 0.016 1 0.823
JNK1JNK1 0.786 0.017 1 0.584
NEK11NEK11 0.785 -0.093 1 0.797
MINKMINK 0.785 0.018 1 0.812
LRRK2LRRK2 0.785 0.049 2 0.749
CDK4CDK4 0.784 0.059 1 0.592
NEK8NEK8 0.784 -0.086 2 0.714
TAK1TAK1 0.783 -0.005 1 0.823
SLKSLK 0.783 0.019 -2 0.702
NEK4NEK4 0.782 -0.081 1 0.813
CDK6CDK6 0.781 0.024 1 0.616
NEK1NEK1 0.781 -0.024 1 0.825
CK2A2CK2A2 0.781 0.040 1 0.669
TTBK1TTBK1 0.780 -0.168 2 0.521
HASPINHASPIN 0.779 0.121 -1 0.757
EEF2KEEF2K 0.779 -0.041 3 0.779
IRAK1IRAK1 0.778 -0.201 -1 0.766
MST2MST2 0.778 -0.105 1 0.813
PDHK3_TYRPDHK3_TYR 0.777 0.300 4 0.889
STK33STK33 0.776 -0.086 2 0.541
PLK2PLK2 0.775 -0.061 -3 0.657
VRK1VRK1 0.773 -0.098 2 0.707
YSK1YSK1 0.772 -0.037 2 0.708
CK2A1CK2A1 0.772 0.034 1 0.650
MST1MST1 0.772 -0.084 1 0.803
YANK3YANK3 0.769 -0.016 2 0.360
LIMK2_TYRLIMK2_TYR 0.769 0.226 -3 0.801
TESK1_TYRTESK1_TYR 0.767 0.142 3 0.839
PDHK4_TYRPDHK4_TYR 0.766 0.117 2 0.818
MAP2K4_TYRMAP2K4_TYR 0.765 0.133 -1 0.873
RIPK2RIPK2 0.764 -0.194 1 0.739
MYO3BMYO3B 0.764 0.003 2 0.738
MEK2MEK2 0.764 -0.232 2 0.717
BIKEBIKE 0.763 0.053 1 0.746
OSR1OSR1 0.763 -0.062 2 0.711
MAP2K6_TYRMAP2K6_TYR 0.763 0.060 -1 0.877
PKMYT1_TYRPKMYT1_TYR 0.762 0.073 3 0.811
CK1ACK1A 0.762 -0.013 -3 0.343
TTKTTK 0.762 -0.041 -2 0.754
ASK1ASK1 0.762 -0.057 1 0.761
MAP2K7_TYRMAP2K7_TYR 0.759 -0.059 2 0.779
NEK3NEK3 0.759 -0.149 1 0.782
PDHK1_TYRPDHK1_TYR 0.758 0.006 -1 0.880
BMPR2_TYRBMPR2_TYR 0.758 0.020 -1 0.868
PINK1_TYRPINK1_TYR 0.756 -0.015 1 0.837
ALPHAK3ALPHAK3 0.756 -0.051 -1 0.770
MYO3AMYO3A 0.756 -0.059 1 0.802
TAO1TAO1 0.755 -0.050 1 0.737
RETRET 0.754 -0.007 1 0.820
EPHA6EPHA6 0.754 0.040 -1 0.839
TNK2TNK2 0.753 0.105 3 0.728
AAK1AAK1 0.753 0.104 1 0.651
LIMK1_TYRLIMK1_TYR 0.751 -0.049 2 0.757
EPHB4EPHB4 0.751 0.012 -1 0.816
ABL2ABL2 0.749 0.035 -1 0.792
MST1RMST1R 0.749 -0.058 3 0.778
ROS1ROS1 0.748 -0.028 3 0.736
TYK2TYK2 0.746 -0.123 1 0.821
DDR1DDR1 0.746 -0.046 4 0.779
TYRO3TYRO3 0.746 -0.090 3 0.762
TNK1TNK1 0.745 0.062 3 0.747
JAK2JAK2 0.745 -0.103 1 0.817
TXKTXK 0.745 0.039 1 0.818
FGRFGR 0.745 -0.010 1 0.867
CSF1RCSF1R 0.745 -0.075 3 0.760
ABL1ABL1 0.744 0.002 -1 0.784
NEK10_TYRNEK10_TYR 0.744 0.015 1 0.710
YES1YES1 0.742 -0.048 -1 0.844
JAK3JAK3 0.742 -0.081 1 0.790
INSRRINSRR 0.741 -0.052 3 0.711
LCKLCK 0.741 0.019 -1 0.820
EPHA4EPHA4 0.740 -0.054 2 0.715
SRMSSRMS 0.739 -0.064 1 0.839
TNNI3K_TYRTNNI3K_TYR 0.738 -0.003 1 0.832
STLK3STLK3 0.738 -0.198 1 0.756
ITKITK 0.738 -0.047 -1 0.793
DDR2DDR2 0.738 0.093 3 0.691
JAK1JAK1 0.738 -0.015 1 0.757
FERFER 0.738 -0.126 1 0.855
KDRKDR 0.737 -0.062 3 0.718
BLKBLK 0.737 0.024 -1 0.819
HCKHCK 0.737 -0.078 -1 0.817
FGFR2FGFR2 0.737 -0.113 3 0.753
EPHB1EPHB1 0.736 -0.089 1 0.836
PDGFRBPDGFRB 0.735 -0.130 3 0.763
KITKIT 0.735 -0.125 3 0.756
EPHB3EPHB3 0.735 -0.084 -1 0.795
AXLAXL 0.734 -0.081 3 0.744
BMXBMX 0.734 -0.028 -1 0.717
MERTKMERTK 0.734 -0.070 3 0.743
METMET 0.733 -0.067 3 0.754
EPHB2EPHB2 0.733 -0.083 -1 0.789
FLT3FLT3 0.733 -0.143 3 0.759
CK1G3CK1G3 0.731 -0.066 -3 0.301
FYNFYN 0.731 -0.002 -1 0.808
WEE1_TYRWEE1_TYR 0.730 -0.071 -1 0.756
LTKLTK 0.730 -0.079 3 0.696
YANK2YANK2 0.730 -0.080 2 0.378
FGFR1FGFR1 0.729 -0.162 3 0.729
TEKTEK 0.728 -0.166 3 0.694
EPHA7EPHA7 0.728 -0.071 2 0.701
ALKALK 0.728 -0.099 3 0.677
PDGFRAPDGFRA 0.727 -0.183 3 0.758
TECTEC 0.727 -0.104 -1 0.723
EPHA1EPHA1 0.727 -0.082 3 0.738
EPHA3EPHA3 0.726 -0.117 2 0.680
FLT1FLT1 0.726 -0.126 -1 0.818
BTKBTK 0.725 -0.191 -1 0.762
FGFR3FGFR3 0.725 -0.138 3 0.725
PTK2BPTK2B 0.724 -0.043 -1 0.753
PTK6PTK6 0.723 -0.185 -1 0.729
NTRK1NTRK1 0.723 -0.195 -1 0.808
PTK2PTK2 0.722 0.013 -1 0.788
INSRINSR 0.721 -0.147 3 0.693
LYNLYN 0.721 -0.117 3 0.675
ERBB2ERBB2 0.721 -0.181 1 0.760
EPHA5EPHA5 0.720 -0.090 2 0.695
FRKFRK 0.720 -0.139 -1 0.810
NTRK3NTRK3 0.718 -0.141 -1 0.762
MATKMATK 0.718 -0.126 -1 0.724
FLT4FLT4 0.718 -0.203 3 0.707
NTRK2NTRK2 0.717 -0.223 3 0.715
SRCSRC 0.717 -0.088 -1 0.800
EPHA8EPHA8 0.717 -0.100 -1 0.784
SYKSYK 0.716 -0.012 -1 0.765
EGFREGFR 0.714 -0.115 1 0.671
CK1G2CK1G2 0.714 -0.054 -3 0.385
CSKCSK 0.713 -0.159 2 0.703
FGFR4FGFR4 0.713 -0.133 -1 0.753
EPHA2EPHA2 0.709 -0.102 -1 0.753
IGF1RIGF1R 0.704 -0.156 3 0.626
ERBB4ERBB4 0.703 -0.088 1 0.683
MUSKMUSK 0.700 -0.175 1 0.674
ZAP70ZAP70 0.699 -0.027 -1 0.699
FESFES 0.689 -0.170 -1 0.695