Motif 187 (n=187)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A1L170 | C1orf226 | S35 | ochoa | Uncharacterized protein C1orf226 | None |
| A4D1P6 | WDR91 | S288 | ochoa | WD repeat-containing protein 91 | Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity). {ECO:0000250|UniProtKB:Q7TMQ7, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. |
| A8K0Z3 | WASHC1 | S340 | ochoa | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| A8MWX3 | WASH4P | S353 | ochoa | Putative WAS protein family homolog 4 (Protein FAM39CP) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| A8MYA2 | CXorf49; | S420 | ochoa | Uncharacterized protein CXorf49 | None |
| C4AMC7 | WASH3P | S338 | ochoa | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| E9PAV3 | NACA | S915 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O00148 | DDX39A | S37 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O00267 | SUPT5H | S773 | ochoa|psp | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}. |
| O14559 | ARHGAP33 | S636 | ochoa | Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein) | May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}. |
| O14578 | CIT | S1317 | ochoa | Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) | Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. |
| O15054 | KDM6B | S218 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
| O15265 | ATXN7 | S492 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O15417 | TNRC18 | S1127 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43294 | TGFB1I1 | S46 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
| O43312 | MTSS1 | S594 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O43847 | NRDC | S61 | ochoa | Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). {ECO:0000250|UniProtKB:Q8BHG1}. |
| O60341 | KDM1A | S80 | ochoa | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| O60341 | KDM1A | S93 | ochoa | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) | Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}. |
| O60499 | STX10 | S143 | ochoa | Syntaxin-10 (Syn10) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| O75122 | CLASP2 | S994 | ochoa | CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}. |
| O75128 | COBL | S916 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75132 | ZBED4 | S640 | ochoa | Zinc finger BED domain-containing protein 4 | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}. |
| O75385 | ULK1 | S639 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75385 | ULK1 | S775 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75962 | TRIO | S1779 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94776 | MTA2 | S352 | ochoa | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| O94804 | STK10 | S488 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94880 | PHF14 | S571 | ochoa | PHD finger protein 14 | Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}. |
| O95208 | EPN2 | S420 | ochoa | Epsin-2 (EPS-15-interacting protein 2) | Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269|PubMed:10567358}. |
| P07101 | TH | S19 | psp | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) | Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). {ECO:0000250|UniProtKB:P04177, ECO:0000250|UniProtKB:P24529, ECO:0000269|PubMed:15287903, ECO:0000269|PubMed:1680128, ECO:0000269|PubMed:17391063, ECO:0000269|PubMed:24753243, ECO:0000269|PubMed:34922205, ECO:0000269|PubMed:8528210, ECO:0000269|Ref.18}.; FUNCTION: [Isoform 5]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}.; FUNCTION: [Isoform 6]: Lacks catalytic activity. {ECO:0000269|PubMed:17391063}. |
| P08151 | GLI1 | S1071 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P10070 | GLI2 | S1014 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P12270 | TPR | S1679 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P13631 | RARG | S36 | ochoa | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
| P17535 | JUND | S43 | ochoa | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}. |
| P17600 | SYN1 | S605 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17676 | CEBPB | S65 | ochoa | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
| P17813 | ENG | S635 | psp | Endoglin (CD antigen CD105) | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. |
| P19484 | TFEB | S133 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20823 | HNF1A | S315 | ochoa | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:10966642, PubMed:12453420). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). {ECO:0000250|UniProtKB:P22361, ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:12453420}.; FUNCTION: (Microbial infection) Plays a crucial role for hepatitis B virus gene transcription and DNA replication. Mechanistically, synergistically cooperates with NR5A2 to up-regulate the activity of one of the critical cis-elements in the hepatitis B virus genome enhancer II (ENII). {ECO:0000269|PubMed:14728801, ECO:0000269|PubMed:38018242}. |
| P22735 | TGM1 | S35 | ochoa | Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:26220141}. |
| P23769 | GATA2 | S73 | psp | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. |
| P27708 | CAD | S1828 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P27816 | MAP4 | S928 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29590 | PML | S535 | ochoa | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P36507 | MAP2K2 | S306 | ochoa|psp | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| P39880 | CUX1 | S1332 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41182 | BCL6 | S427 | ochoa | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P46821 | MAP1B | S1412 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S765 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P50402 | EMD | S123 | ochoa | Emerin | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649, ECO:0000269|PubMed:32923640}. |
| P56693 | SOX10 | S232 | psp | Transcription factor SOX-10 | Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {ECO:0000250|UniProtKB:O55170, ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}. |
| P56945 | BCAR1 | S292 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P57737 | CORO7 | S879 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| P85037 | FOXK1 | S488 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
| P98082 | DAB2 | S449 | ochoa | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}. |
| Q01201 | RELB | S472 | psp | Transcription factor RelB (I-Rel) | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063). {ECO:0000269|PubMed:1732739, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063, ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}. |
| Q03164 | KMT2A | S2167 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05209 | PTPN12 | S556 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q08495 | DMTN | S103 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q09472 | EP300 | S2039 | psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12772 | SREBF2 | S117 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12815 | TROAP | S271 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13112 | CHAF1B | S464 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13191 | CBLB | S886 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13443 | ADAM9 | Y769 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q13625 | TP53BP2 | S611 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14149 | MORC3 | S514 | ochoa | MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26933034, ECO:0000269|PubMed:27440897, ECO:0000269|PubMed:34759314}.; FUNCTION: (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:26202233}. |
| Q14160 | SCRIB | S432 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14814 | MEF2D | S242 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q14872 | MTF1 | S620 | psp | Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}. |
| Q15311 | RALBP1 | S22 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15648 | MED1 | S816 | psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q4G0T1 | SCART1 | S756 | ochoa | Scavenger receptor cysteine-rich domain-containing protein SCART1 (Scavenger receptor family member expressed on T cells 1) | May play a role in the immune system, perhaps as a co-receptor on alphabeta and gammadelta T-cells. {ECO:0000305|PubMed:22795646}. |
| Q4KMP7 | TBC1D10B | S661 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q4KMP7 | TBC1D10B | S718 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5SQI0 | ATAT1 | S272 | ochoa | Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}. |
| Q5SY16 | NOL9 | S93 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5T1R4 | HIVEP3 | S2009 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5VY43 | PEAR1 | S964 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q66K74 | MAP1S | S770 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q69YQ0 | SPECC1L | S881 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6P3S6 | FBXO42 | S595 | ochoa | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269|PubMed:19509332}. |
| Q6PKG0 | LARP1 | S574 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6VEQ5 | WASH2P | S340 | ochoa | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q6W2J9 | BCOR | S669 | ochoa | BCL-6 corepressor (BCoR) | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}. |
| Q6ZSY5 | PPP1R3F | S401 | ochoa | Protein phosphatase 1 regulatory subunit 3F (R3F) | Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}. |
| Q6ZUT6 | CCDC9B | S403 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q6ZVL6 | KIAA1549L | S1274 | ochoa | UPF0606 protein KIAA1549L | None |
| Q765P7 | MTSS2 | S569 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q765P7 | MTSS2 | S612 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L591 | DOK3 | S330 | ochoa | Docking protein 3 (Downstream of tyrosine kinase 3) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}. |
| Q7Z406 | MYH14 | S595 | ochoa | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Q86U90 | YRDC | S53 | ochoa | Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) | Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250|UniProtKB:Q3U5F4, ECO:0000269|PubMed:29760464, ECO:0000269|PubMed:31481669, ECO:0000269|PubMed:34545459}. |
| Q86UD3 | MARCHF3 | S79 | ochoa | E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3) | E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000250|UniProtKB:Q5XIE5}. |
| Q86UE8 | TLK2 | S115 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86V42 | FAM124A | S321 | ochoa | Protein FAM124A | None |
| Q86WB0 | ZC3HC1 | S381 | ochoa|psp | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86X29 | LSR | S432 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q8IU68 | TMC8 | S694 | ochoa | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) | Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:23429285, ECO:0000269|PubMed:25220380, ECO:0000269|PubMed:30068544, ECO:0000269|PubMed:32917726}. |
| Q8IY33 | MICALL2 | S310 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IY63 | AMOTL1 | S805 | ochoa|psp | Angiomotin-like protein 1 | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
| Q8N1G0 | ZNF687 | S227 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1G0 | ZNF687 | S1196 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N3F8 | MICALL1 | S493 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S555 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N4X5 | AFAP1L2 | S651 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8NCD3 | HJURP | S201 | ochoa | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8ND24 | RNF214 | S506 | ochoa | RING finger protein 214 | None |
| Q8ND56 | LSM14A | S203 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NEY1 | NAV1 | S672 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NEZ4 | KMT2C | S177 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TB45 | DEPTOR | S316 | ochoa | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TER5 | ARHGEF40 | S266 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUA4 | GTF3C2 | S776 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WWM7 | ATXN2L | S67 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92540 | SMG7 | S786 | ochoa | Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7) | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}. |
| Q92610 | ZNF592 | S1100 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92619 | ARHGAP45 | S53 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92619 | ARHGAP45 | S951 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92734 | TFG | S369 | ochoa | Protein TFG (TRK-fused gene protein) | Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}. |
| Q92918 | MAP4K1 | S421 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92997 | DVL3 | S564 | psp | Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) | Involved in the signal transduction pathway mediated by multiple Wnt genes. {ECO:0000250|UniProtKB:Q61062}. |
| Q96BT3 | CENPT | S160 | ochoa | Centromere protein T (CENP-T) (Interphase centromere complex protein 22) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}. |
| Q96EK9 | KTI12 | S200 | ochoa | Protein KTI12 homolog | None |
| Q96EP0 | RNF31 | S472 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96HB5 | CCDC120 | S302 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96HB5 | CCDC120 | S393 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96JM3 | CHAMP1 | S443 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96LL9 | DNAJC30 | S39 | ochoa | DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein) | Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (PubMed:33465056). {ECO:0000250|UniProtKB:P59041, ECO:0000269|PubMed:33465056}. |
| Q96MX3 | ZNF48 | S420 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q96PK6 | RBM14 | S244 | ochoa | RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein) | Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CPAP complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CPAP (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also involved in the regulation of pre-mRNA alternative splicing (PubMed:37548402). {ECO:0000269|PubMed:11443112, ECO:0000269|PubMed:25385835, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:37548402}. |
| Q96Q45 | TMEM237 | S49 | ochoa | Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein) | Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269|PubMed:22152675}. |
| Q96QT4 | TRPM7 | S1407 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RT1 | ERBIN | S984 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
| Q96ST3 | SIN3A | S251 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99569 | PKP4 | S314 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99569 | PKP4 | S438 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99988 | GDF15 | S97 | ochoa | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) | Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844, ECO:0000269|PubMed:24971956, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:30639358, ECO:0000269|PubMed:31402172, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:31875646, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:33589633, ECO:0000269|PubMed:36001956, ECO:0000269|PubMed:37060902, ECO:0000269|PubMed:38092039}. |
| Q9BQQ3 | GORASP1 | S248 | ochoa | Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}. |
| Q9BUK6 | MSTO1 | S486 | ochoa | Protein misato homolog 1 | Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28544275, PubMed:28554942). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28544275, PubMed:28554942). {ECO:0000269|PubMed:17349998, ECO:0000269|PubMed:28544275, ECO:0000269|PubMed:28554942}. |
| Q9BUL5 | PHF23 | S305 | ochoa | PHD finger protein 23 (PDH-containing protein JUNE-1) | Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}. |
| Q9BX40 | LSM14B | S165 | ochoa | Protein LSM14 homolog B (RNA-associated protein 55B) (hRAP55B) | mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary. {ECO:0000250|UniProtKB:Q8CGC4}. |
| Q9C0C2 | TNKS1BP1 | S387 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C2 | TNKS1BP1 | S1463 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9GZV5 | WWTR1 | S296 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H0X9 | OSBPL5 | S35 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9HAH7 | FBRS | S230 | ochoa | Probable fibrosin-1 | None |
| Q9HBR0 | SLC38A10 | S802 | ochoa | Solute carrier family 38 member 10 (Amino acid transporter SLC38A10) | Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:Q5I012}. |
| Q9HCK8 | CHD8 | S277 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NPI6 | DCP1A | S364 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NVE7 | PANK4 | S404 | ochoa | 4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4) | Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable). {ECO:0000269|PubMed:27322068, ECO:0000305|PubMed:27322068}. |
| Q9NX94 | WBP1L | S159 | ochoa | WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) | None |
| Q9NYB9 | ABI2 | S187 | psp | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9P275 | USP36 | S557 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2E9 | RRBP1 | S655 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UBC2 | EPS15L1 | S371 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBC2 | EPS15L1 | S672 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UEE9 | CFDP1 | S216 | ochoa | Craniofacial development protein 1 (Bucentaur) | May play a role during embryogenesis. {ECO:0000250}. |
| Q9UET6 | FTSJ1 | S217 | ochoa | tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). Requisite for faithful cytoplasmic translation (PubMed:32393790). Requires THADA for methylation of the nucleotide at position 32 of the anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:26310293). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Promotes translation efficiency of the UUU codon (PubMed:32558197). Plays a role in neurogenesis (PubMed:36720500). Required for expression of genes involved in neurogenesis, mitochondrial translation and energy generation, and lipid biosynthesis (PubMed:33771871, PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:36720500). May modify position 32 in tRNA(Arg(ACG)), tRNA(Arg(CCG)), tRNA(Arg(UCG)), tRNA(Cys(GCA)), tRNA(Cys(ACA)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gly(CCC)), tRNA(Leu(CAG))/tRNA(Leu(CAA)), tRNA(Leu(A/IAG)), tRNA(Leu(UAG)), tRNA(Phe(GAA)), tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG)) and tRNA(Trp(CCA)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500). {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}. |
| Q9UHB6 | LIMA1 | S114 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | S498 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UHV7 | MED13 | S2042 | ochoa | Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
| Q9UIF9 | BAZ2A | S1207 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UPQ0 | LIMCH1 | S325 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPT8 | ZC3H4 | S764 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQQ2 | SH2B3 | S531 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y2B5 | VPS9D1 | S330 | ochoa | VPS9 domain-containing protein 1 (Protein ATP-BL) | None |
| Q9Y2L6 | FRMD4B | S926 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y2W1 | THRAP3 | S331 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4B6 | DCAF1 | S915 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4B6 | DCAF1 | S946 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
| Q9Y4F1 | FARP1 | S889 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4G6 | TLN2 | S646 | ochoa | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| Q9Y566 | SHANK1 | S890 | ochoa | SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| A8K0Z3 | WASHC1 | S105 | Sugiyama | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853). Involved in endocytic trafficking of EGF (By similarity). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:23452853, ECO:0000305|PubMed:20498093}. |
| C4AMC7 | WASH3P | S105 | Sugiyama | Putative WAS protein family homolog 3 (Protein FAM39DP) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:18159949, PubMed:20175130). Involved in endocytic trafficking of EGF (PubMed:20175130). Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (By similarity). In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling (By similarity). Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (By similarity). Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:18159949, ECO:0000269|PubMed:20175130}. |
| Q6VEQ5 | WASH2P | S105 | Sugiyama | WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B) | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7, ECO:0000250|UniProtKB:Q8VDD8}. |
| Q9NQA3 | WASH6P | S87 | Sugiyama | WAS protein family homolog 6 (Protein FAM39A) | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:C4AMC7}. |
| Q9BX68 | HINT2 | S63 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| P19447 | ERCC3 | S90 | SIGNOR|PSP | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}. |
| Q96EP5 | DAZAP1 | S208 | Sugiyama | DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1) | RNA-binding protein, which may be required during spermatogenesis. |
| Q9C0C2 | TNKS1BP1 | S77 | Sugiyama | 182 kDa tankyrase-1-binding protein | None |
| P78344 | EIF4G2 | S36 | Sugiyama | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| Q9UHG3 | PCYOX1 | S447 | Sugiyama | Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase) | Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463). {ECO:0000250|UniProtKB:F1N2K1, ECO:0000269|PubMed:10585463, ECO:0000269|PubMed:11078725, ECO:0000269|PubMed:12186880}. |
| Q9NZB2 | FAM120A | S30 | Sugiyama | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.000027 | 4.576 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.000137 | 3.864 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.000357 | 3.447 |
| R-HSA-9843745 | Adipogenesis | 0.000463 | 3.335 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.002438 | 2.613 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.002849 | 2.545 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.002175 | 2.663 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.003432 | 2.464 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.003432 | 2.464 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.004920 | 2.308 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.005674 | 2.246 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.006671 | 2.176 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.009236 | 2.035 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.012077 | 1.918 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.012917 | 1.889 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.047053 | 1.327 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.047053 | 1.327 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.047053 | 1.327 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.047053 | 1.327 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.047053 | 1.327 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.047053 | 1.327 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.047053 | 1.327 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.047053 | 1.327 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.047053 | 1.327 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.047053 | 1.327 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.047053 | 1.327 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.058468 | 1.233 |
| R-HSA-5660489 | MTF1 activates gene expression | 0.069746 | 1.156 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.069746 | 1.156 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 0.069746 | 1.156 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.080891 | 1.092 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.080891 | 1.092 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.080891 | 1.092 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.091902 | 1.037 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.091902 | 1.037 |
| R-HSA-196025 | Formation of annular gap junctions | 0.124156 | 0.906 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.134652 | 0.871 |
| R-HSA-190873 | Gap junction degradation | 0.134652 | 0.871 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.134652 | 0.871 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 0.134652 | 0.871 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.048373 | 1.315 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.048373 | 1.315 |
| R-HSA-429947 | Deadenylation of mRNA | 0.051368 | 1.289 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.165394 | 0.781 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.175398 | 0.756 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.060735 | 1.217 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.063978 | 1.194 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.036678 | 1.436 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.038213 | 1.418 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.232967 | 0.633 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.110707 | 0.956 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.251253 | 0.600 |
| R-HSA-774815 | Nucleosome assembly | 0.134538 | 0.871 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.134538 | 0.871 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.277873 | 0.556 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.277873 | 0.556 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.277873 | 0.556 |
| R-HSA-1989781 | PPARA activates gene expression | 0.019160 | 1.718 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.328320 | 0.484 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.328320 | 0.484 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.336380 | 0.473 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.336380 | 0.473 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.352213 | 0.453 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.359988 | 0.444 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.359988 | 0.444 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.375260 | 0.426 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.375260 | 0.426 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.255332 | 0.593 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.189127 | 0.723 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.189127 | 0.723 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.277546 | 0.557 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.295293 | 0.530 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.312978 | 0.504 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.312978 | 0.504 |
| R-HSA-167172 | Transcription of the HIV genome | 0.233159 | 0.632 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.185283 | 0.732 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.057551 | 1.240 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.110707 | 0.956 |
| R-HSA-167169 | HIV Transcription Elongation | 0.110707 | 0.956 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.145022 | 0.839 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.185283 | 0.732 |
| R-HSA-72086 | mRNA Capping | 0.067278 | 1.172 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.088866 | 1.051 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.063978 | 1.194 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.106854 | 0.971 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.286535 | 0.543 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.090350 | 1.044 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.090350 | 1.044 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.055317 | 1.257 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.175398 | 0.756 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.223657 | 0.650 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.328320 | 0.484 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.090350 | 1.044 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.175398 | 0.756 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.260233 | 0.585 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.077617 | 1.110 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.018649 | 1.729 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.070633 | 1.151 |
| R-HSA-9664420 | Killing mechanisms | 0.214236 | 0.669 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.214236 | 0.669 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.165371 | 0.782 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.165371 | 0.782 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.016291 | 1.788 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.352213 | 0.453 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.303633 | 0.518 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.165394 | 0.781 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.020825 | 1.681 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.015892 | 1.799 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.328320 | 0.484 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.246453 | 0.608 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.306906 | 0.513 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.058397 | 1.234 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.195050 | 0.710 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.046303 | 1.334 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.058468 | 1.233 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.165394 | 0.781 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.048099 | 1.318 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.242165 | 0.616 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.242165 | 0.616 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.277546 | 0.557 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.242165 | 0.616 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.028154 | 1.550 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.071192 | 1.148 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.022440 | 1.649 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.295293 | 0.530 |
| R-HSA-9909396 | Circadian clock | 0.034468 | 1.463 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.175398 | 0.756 |
| R-HSA-75893 | TNF signaling | 0.043012 | 1.366 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.251253 | 0.600 |
| R-HSA-9620244 | Long-term potentiation | 0.311907 | 0.506 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.070633 | 1.151 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.204701 | 0.689 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.344344 | 0.463 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.118847 | 0.925 |
| R-HSA-162587 | HIV Life Cycle | 0.352768 | 0.453 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.091902 | 1.037 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.113533 | 0.945 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.286535 | 0.543 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.295094 | 0.530 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.176379 | 0.754 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.375260 | 0.426 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.268661 | 0.571 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.242018 | 0.616 |
| R-HSA-9729555 | Sensory perception of sour taste | 0.069746 | 1.156 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.091902 | 1.037 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.102783 | 0.988 |
| R-HSA-8964046 | VLDL clearance | 0.113533 | 0.945 |
| R-HSA-2028269 | Signaling by Hippo | 0.029391 | 1.532 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.039795 | 1.400 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.223657 | 0.650 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.022537 | 1.647 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.242165 | 0.616 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.122479 | 0.912 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.352213 | 0.453 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.162467 | 0.789 |
| R-HSA-4086400 | PCP/CE pathway | 0.277546 | 0.557 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.304145 | 0.517 |
| R-HSA-182971 | EGFR downregulation | 0.074042 | 1.131 |
| R-HSA-170968 | Frs2-mediated activation | 0.185283 | 0.732 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.303551 | 0.518 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.184983 | 0.733 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.114843 | 0.940 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.091830 | 1.037 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.102783 | 0.988 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.145022 | 0.839 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.195050 | 0.710 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.099261 | 1.003 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.375260 | 0.426 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.375260 | 0.426 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.373933 | 0.427 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.051368 | 1.289 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.223657 | 0.650 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.227566 | 0.643 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.242165 | 0.616 |
| R-HSA-68875 | Mitotic Prophase | 0.219938 | 0.658 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.080891 | 1.092 |
| R-HSA-389542 | NADPH regeneration | 0.102783 | 0.988 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.113533 | 0.945 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.134652 | 0.871 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.145022 | 0.839 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.165394 | 0.781 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.185283 | 0.732 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.204701 | 0.689 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.214236 | 0.669 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.099261 | 1.003 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.277873 | 0.556 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.286535 | 0.543 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.328320 | 0.484 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.025978 | 1.585 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.180673 | 0.743 |
| R-HSA-3214842 | HDMs demethylate histones | 0.054428 | 1.264 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.344344 | 0.463 |
| R-HSA-186712 | Regulation of beta-cell development | 0.193645 | 0.713 |
| R-HSA-8953854 | Metabolism of RNA | 0.337025 | 0.472 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.175398 | 0.756 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.030581 | 1.515 |
| R-HSA-73887 | Death Receptor Signaling | 0.018684 | 1.729 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.197996 | 0.703 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.070633 | 1.151 |
| R-HSA-169893 | Prolonged ERK activation events | 0.214236 | 0.669 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.080891 | 1.092 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.175398 | 0.756 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.175398 | 0.756 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.175398 | 0.756 |
| R-HSA-200425 | Carnitine shuttle | 0.295094 | 0.530 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.197996 | 0.703 |
| R-HSA-9930044 | Nuclear RNA decay | 0.375260 | 0.426 |
| R-HSA-74160 | Gene expression (Transcription) | 0.284369 | 0.546 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.030863 | 1.511 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.223657 | 0.650 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.277546 | 0.557 |
| R-HSA-109581 | Apoptosis | 0.369092 | 0.433 |
| R-HSA-8939211 | ESR-mediated signaling | 0.374478 | 0.427 |
| R-HSA-195721 | Signaling by WNT | 0.337867 | 0.471 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.061237 | 1.213 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.145022 | 0.839 |
| R-HSA-5578768 | Physiological factors | 0.195050 | 0.710 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.204701 | 0.689 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.214236 | 0.669 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.223657 | 0.650 |
| R-HSA-209905 | Catecholamine biosynthesis | 0.232967 | 0.633 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.242165 | 0.616 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.320163 | 0.495 |
| R-HSA-2559583 | Cellular Senescence | 0.219954 | 0.658 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.248912 | 0.604 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.071192 | 1.148 |
| R-HSA-9707616 | Heme signaling | 0.053466 | 1.272 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.328320 | 0.484 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.180673 | 0.743 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.015634 | 1.806 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.320163 | 0.495 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.250891 | 0.601 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.079814 | 1.098 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.073306 | 1.135 |
| R-HSA-525793 | Myogenesis | 0.057551 | 1.240 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.204701 | 0.689 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.043012 | 1.366 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.260233 | 0.585 |
| R-HSA-8854214 | TBC/RABGAPs | 0.126468 | 0.898 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.277873 | 0.556 |
| R-HSA-3295583 | TRP channels | 0.320163 | 0.495 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.336380 | 0.473 |
| R-HSA-177929 | Signaling by EGFR | 0.180673 | 0.743 |
| R-HSA-1266738 | Developmental Biology | 0.048156 | 1.317 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.114597 | 0.941 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.352213 | 0.453 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.242165 | 0.616 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.269106 | 0.570 |
| R-HSA-212436 | Generic Transcription Pathway | 0.262192 | 0.581 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.045062 | 1.346 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.035383 | 1.451 |
| R-HSA-5660526 | Response to metal ions | 0.223657 | 0.650 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.113533 | 0.945 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.195050 | 0.710 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 0.242165 | 0.616 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.079814 | 1.098 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.286535 | 0.543 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.311907 | 0.506 |
| R-HSA-9839394 | TGFBR3 expression | 0.311907 | 0.506 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.336380 | 0.473 |
| R-HSA-354192 | Integrin signaling | 0.375260 | 0.426 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.168916 | 0.772 |
| R-HSA-201556 | Signaling by ALK | 0.106854 | 0.971 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.269106 | 0.570 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.086947 | 1.061 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.223657 | 0.650 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.269106 | 0.570 |
| R-HSA-9833110 | RSV-host interactions | 0.052792 | 1.277 |
| R-HSA-9675108 | Nervous system development | 0.304077 | 0.517 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.134919 | 0.870 |
| R-HSA-162582 | Signal Transduction | 0.039755 | 1.401 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.095758 | 1.019 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.082687 | 1.083 |
| R-HSA-6807070 | PTEN Regulation | 0.120872 | 0.918 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.352213 | 0.453 |
| R-HSA-4839726 | Chromatin organization | 0.045682 | 1.340 |
| R-HSA-111458 | Formation of apoptosome | 0.145022 | 0.839 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.185283 | 0.732 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.277873 | 0.556 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.189307 | 0.723 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.078330 | 1.106 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.126711 | 0.897 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.030863 | 1.511 |
| R-HSA-445144 | Signal transduction by L1 | 0.260233 | 0.585 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.359988 | 0.444 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.373933 | 0.427 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.309314 | 0.510 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.311907 | 0.506 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.367670 | 0.435 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.070633 | 1.151 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.286535 | 0.543 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.184983 | 0.733 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.375260 | 0.426 |
| R-HSA-166520 | Signaling by NTRKs | 0.141915 | 0.848 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.086564 | 1.063 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.273104 | 0.564 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.240917 | 0.618 |
| R-HSA-186797 | Signaling by PDGF | 0.206733 | 0.685 |
| R-HSA-186763 | Downstream signal transduction | 0.359988 | 0.444 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.290861 | 0.536 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.375260 | 0.426 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.075448 | 1.122 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.145596 | 0.837 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.348031 | 0.458 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.320163 | 0.495 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.232967 | 0.633 |
| R-HSA-8964038 | LDL clearance | 0.286535 | 0.543 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.375260 | 0.426 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.299721 | 0.523 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.116837 | 0.932 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.375260 | 0.426 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.342949 | 0.465 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.148192 | 0.829 |
| R-HSA-3214847 | HATs acetylate histones | 0.382477 | 0.417 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.382760 | 0.417 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.382760 | 0.417 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.382760 | 0.417 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.382760 | 0.417 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.382760 | 0.417 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.386731 | 0.413 |
| R-HSA-70171 | Glycolysis | 0.386731 | 0.413 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.390170 | 0.409 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.390170 | 0.409 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.390170 | 0.409 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.390170 | 0.409 |
| R-HSA-5205647 | Mitophagy | 0.390170 | 0.409 |
| R-HSA-5673000 | RAF activation | 0.390170 | 0.409 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.390170 | 0.409 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.395199 | 0.403 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.397492 | 0.401 |
| R-HSA-187687 | Signalling to ERKs | 0.397492 | 0.401 |
| R-HSA-381042 | PERK regulates gene expression | 0.397492 | 0.401 |
| R-HSA-72306 | tRNA processing | 0.398278 | 0.400 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.403614 | 0.394 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.404726 | 0.393 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.404726 | 0.393 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.404726 | 0.393 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.411873 | 0.385 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.411873 | 0.385 |
| R-HSA-4641258 | Degradation of DVL | 0.411873 | 0.385 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.411873 | 0.385 |
| R-HSA-199991 | Membrane Trafficking | 0.415949 | 0.381 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.418936 | 0.378 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.418936 | 0.378 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.425914 | 0.371 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.425914 | 0.371 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.425914 | 0.371 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.428518 | 0.368 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.432808 | 0.364 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.432808 | 0.364 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.432808 | 0.364 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.432808 | 0.364 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.432808 | 0.364 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.432808 | 0.364 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.432808 | 0.364 |
| R-HSA-3371568 | Attenuation phase | 0.432808 | 0.364 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.432808 | 0.364 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.432808 | 0.364 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.439620 | 0.357 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.439620 | 0.357 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.439620 | 0.357 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.439620 | 0.357 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.439620 | 0.357 |
| R-HSA-9607240 | FLT3 Signaling | 0.439620 | 0.357 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.439620 | 0.357 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.446351 | 0.350 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.446351 | 0.350 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.446351 | 0.350 |
| R-HSA-167161 | HIV Transcription Initiation | 0.446351 | 0.350 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.446351 | 0.350 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.446351 | 0.350 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.446351 | 0.350 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.446351 | 0.350 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.446351 | 0.350 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.446351 | 0.350 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.446351 | 0.350 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.446351 | 0.350 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.453002 | 0.344 |
| R-HSA-73928 | Depyrimidination | 0.453002 | 0.344 |
| R-HSA-165159 | MTOR signalling | 0.453002 | 0.344 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.459572 | 0.338 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.459572 | 0.338 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.460854 | 0.336 |
| R-HSA-190828 | Gap junction trafficking | 0.466065 | 0.332 |
| R-HSA-373752 | Netrin-1 signaling | 0.466065 | 0.332 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.466065 | 0.332 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.466065 | 0.332 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.468772 | 0.329 |
| R-HSA-70326 | Glucose metabolism | 0.468772 | 0.329 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.468772 | 0.329 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.472480 | 0.326 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.472480 | 0.326 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.472480 | 0.326 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.472480 | 0.326 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.472480 | 0.326 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.472480 | 0.326 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.478818 | 0.320 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.478818 | 0.320 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.478818 | 0.320 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.478818 | 0.320 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.478818 | 0.320 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.478818 | 0.320 |
| R-HSA-75153 | Apoptotic execution phase | 0.478818 | 0.320 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.478818 | 0.320 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.484400 | 0.315 |
| R-HSA-73886 | Chromosome Maintenance | 0.484400 | 0.315 |
| R-HSA-3371556 | Cellular response to heat stress | 0.484400 | 0.315 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.485080 | 0.314 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.490804 | 0.309 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.495933 | 0.305 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.497381 | 0.303 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.497381 | 0.303 |
| R-HSA-194138 | Signaling by VEGF | 0.503531 | 0.298 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.509389 | 0.293 |
| R-HSA-5357801 | Programmed Cell Death | 0.510208 | 0.292 |
| R-HSA-72187 | mRNA 3'-end processing | 0.515286 | 0.288 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.515286 | 0.288 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.515286 | 0.288 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.515286 | 0.288 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.521113 | 0.283 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.521113 | 0.283 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.521113 | 0.283 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.521113 | 0.283 |
| R-HSA-72649 | Translation initiation complex formation | 0.526869 | 0.278 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.526869 | 0.278 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.527089 | 0.278 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.532557 | 0.274 |
| R-HSA-68886 | M Phase | 0.535684 | 0.271 |
| R-HSA-913531 | Interferon Signaling | 0.537882 | 0.269 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.538177 | 0.269 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.538177 | 0.269 |
| R-HSA-209776 | Metabolism of amine-derived hormones | 0.538177 | 0.269 |
| R-HSA-68882 | Mitotic Anaphase | 0.542245 | 0.266 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.545098 | 0.264 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.549215 | 0.260 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.549215 | 0.260 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.549215 | 0.260 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.551085 | 0.259 |
| R-HSA-191859 | snRNP Assembly | 0.554636 | 0.256 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.554636 | 0.256 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.559991 | 0.252 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.559991 | 0.252 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.559991 | 0.252 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.559991 | 0.252 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.559991 | 0.252 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.559991 | 0.252 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.559991 | 0.252 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.559991 | 0.252 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.563880 | 0.249 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.565283 | 0.248 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.565283 | 0.248 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.565283 | 0.248 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.565283 | 0.248 |
| R-HSA-1442490 | Collagen degradation | 0.565283 | 0.248 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.570511 | 0.244 |
| R-HSA-162906 | HIV Infection | 0.573052 | 0.242 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.575340 | 0.240 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.575677 | 0.240 |
| R-HSA-8848021 | Signaling by PTK6 | 0.575677 | 0.240 |
| R-HSA-373755 | Semaphorin interactions | 0.575677 | 0.240 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.585823 | 0.232 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.585823 | 0.232 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.590806 | 0.229 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.592075 | 0.228 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.600593 | 0.221 |
| R-HSA-5218859 | Regulated Necrosis | 0.600593 | 0.221 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.601879 | 0.220 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.601879 | 0.220 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.608317 | 0.216 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.610146 | 0.215 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.610146 | 0.215 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.610146 | 0.215 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.610146 | 0.215 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.614838 | 0.211 |
| R-HSA-8978934 | Metabolism of cofactors | 0.614838 | 0.211 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.619473 | 0.208 |
| R-HSA-9711097 | Cellular response to starvation | 0.627156 | 0.203 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.628577 | 0.202 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.628577 | 0.202 |
| R-HSA-877300 | Interferon gamma signaling | 0.630228 | 0.201 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.633048 | 0.199 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.633048 | 0.199 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.633279 | 0.198 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.636476 | 0.196 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.637465 | 0.196 |
| R-HSA-5689603 | UCH proteinases | 0.637465 | 0.196 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.645289 | 0.190 |
| R-HSA-5688426 | Deubiquitination | 0.645447 | 0.190 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.646141 | 0.190 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.646141 | 0.190 |
| R-HSA-9659379 | Sensory processing of sound | 0.650401 | 0.187 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.654611 | 0.184 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.666938 | 0.176 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.668379 | 0.175 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.670949 | 0.173 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.671702 | 0.173 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.674912 | 0.171 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.674912 | 0.171 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.674912 | 0.171 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.675990 | 0.170 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.678828 | 0.168 |
| R-HSA-422475 | Axon guidance | 0.679936 | 0.168 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.682697 | 0.166 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.686519 | 0.163 |
| R-HSA-9663891 | Selective autophagy | 0.690295 | 0.161 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.697713 | 0.156 |
| R-HSA-73884 | Base Excision Repair | 0.697713 | 0.156 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.701355 | 0.154 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.701355 | 0.154 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.704954 | 0.152 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.706680 | 0.151 |
| R-HSA-69275 | G2/M Transition | 0.708399 | 0.150 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.708509 | 0.150 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.713421 | 0.147 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.718922 | 0.143 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.723248 | 0.141 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.725658 | 0.139 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.725658 | 0.139 |
| R-HSA-68877 | Mitotic Prometaphase | 0.725660 | 0.139 |
| R-HSA-9609690 | HCMV Early Events | 0.732791 | 0.135 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.732791 | 0.135 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.742054 | 0.130 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.744915 | 0.128 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.744915 | 0.128 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.744915 | 0.128 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.746583 | 0.127 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.748821 | 0.126 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.757001 | 0.121 |
| R-HSA-6805567 | Keratinization | 0.757608 | 0.121 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.759932 | 0.119 |
| R-HSA-211000 | Gene Silencing by RNA | 0.762828 | 0.118 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.765689 | 0.116 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.765689 | 0.116 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.765689 | 0.116 |
| R-HSA-397014 | Muscle contraction | 0.770291 | 0.113 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.773654 | 0.111 |
| R-HSA-6803157 | Antimicrobial peptides | 0.774069 | 0.111 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.776795 | 0.110 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.778761 | 0.109 |
| R-HSA-1640170 | Cell Cycle | 0.778982 | 0.108 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.779489 | 0.108 |
| R-HSA-418990 | Adherens junctions interactions | 0.782396 | 0.107 |
| R-HSA-8957322 | Metabolism of steroids | 0.785435 | 0.105 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.792479 | 0.101 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.792479 | 0.101 |
| R-HSA-373760 | L1CAM interactions | 0.792479 | 0.101 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.801334 | 0.096 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.804708 | 0.094 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.811699 | 0.091 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.820654 | 0.086 |
| R-HSA-9824446 | Viral Infection Pathways | 0.822601 | 0.085 |
| R-HSA-9679506 | SARS-CoV Infections | 0.826389 | 0.083 |
| R-HSA-6798695 | Neutrophil degranulation | 0.830083 | 0.081 |
| R-HSA-9717189 | Sensory perception of taste | 0.831211 | 0.080 |
| R-HSA-5576891 | Cardiac conduction | 0.831211 | 0.080 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.833251 | 0.079 |
| R-HSA-9609646 | HCMV Infection | 0.837950 | 0.077 |
| R-HSA-421270 | Cell-cell junction organization | 0.839460 | 0.076 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.848711 | 0.071 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.849683 | 0.071 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.850540 | 0.070 |
| R-HSA-9664407 | Parasite infection | 0.850540 | 0.070 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.850540 | 0.070 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.852348 | 0.069 |
| R-HSA-1632852 | Macroautophagy | 0.852348 | 0.069 |
| R-HSA-416476 | G alpha (q) signalling events | 0.857973 | 0.067 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.867004 | 0.062 |
| R-HSA-9758941 | Gastrulation | 0.867666 | 0.062 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.870850 | 0.060 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.872413 | 0.059 |
| R-HSA-9609507 | Protein localization | 0.873957 | 0.059 |
| R-HSA-446728 | Cell junction organization | 0.875721 | 0.058 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.876907 | 0.057 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.876989 | 0.057 |
| R-HSA-9612973 | Autophagy | 0.878478 | 0.056 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.879249 | 0.056 |
| R-HSA-9658195 | Leishmania infection | 0.879249 | 0.056 |
| R-HSA-9610379 | HCMV Late Events | 0.879949 | 0.056 |
| R-HSA-2262752 | Cellular responses to stress | 0.884163 | 0.053 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.888214 | 0.051 |
| R-HSA-5619102 | SLC transporter disorders | 0.893720 | 0.049 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.895550 | 0.048 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.898778 | 0.046 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.901479 | 0.045 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.902413 | 0.045 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.902413 | 0.045 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.902413 | 0.045 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.903596 | 0.044 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.904764 | 0.043 |
| R-HSA-168255 | Influenza Infection | 0.909298 | 0.041 |
| R-HSA-1500931 | Cell-Cell communication | 0.914123 | 0.039 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.918731 | 0.037 |
| R-HSA-983712 | Ion channel transport | 0.919717 | 0.036 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.919861 | 0.036 |
| R-HSA-5617833 | Cilium Assembly | 0.920691 | 0.036 |
| R-HSA-109582 | Hemostasis | 0.925784 | 0.033 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.932332 | 0.030 |
| R-HSA-112316 | Neuronal System | 0.935833 | 0.029 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.938177 | 0.028 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.940115 | 0.027 |
| R-HSA-73894 | DNA Repair | 0.944670 | 0.025 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.946866 | 0.024 |
| R-HSA-1280218 | Adaptive Immune System | 0.947583 | 0.023 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.951949 | 0.021 |
| R-HSA-72312 | rRNA processing | 0.953111 | 0.021 |
| R-HSA-449147 | Signaling by Interleukins | 0.954093 | 0.020 |
| R-HSA-15869 | Metabolism of nucleotides | 0.955351 | 0.020 |
| R-HSA-157118 | Signaling by NOTCH | 0.957485 | 0.019 |
| R-HSA-5663205 | Infectious disease | 0.957826 | 0.019 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.960978 | 0.017 |
| R-HSA-168256 | Immune System | 0.962757 | 0.016 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.971040 | 0.013 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.971976 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 0.978346 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.979518 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.986094 | 0.006 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.987706 | 0.005 |
| R-HSA-1643685 | Disease | 0.990171 | 0.004 |
| R-HSA-168249 | Innate Immune System | 0.993367 | 0.003 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.993368 | 0.003 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.993918 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.994625 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.995326 | 0.002 |
| R-HSA-72766 | Translation | 0.995907 | 0.002 |
| R-HSA-388396 | GPCR downstream signalling | 0.996661 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998275 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.998594 | 0.001 |
| R-HSA-597592 | Post-translational protein modification | 0.999601 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999612 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999998 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.867 | 0.332 | 1 | 0.880 |
HIPK4 |
0.866 | 0.356 | 1 | 0.848 |
SRPK1 |
0.859 | 0.278 | -3 | 0.782 |
PIM3 |
0.857 | 0.213 | -3 | 0.840 |
COT |
0.856 | 0.083 | 2 | 0.810 |
CDKL5 |
0.855 | 0.253 | -3 | 0.819 |
PRKD1 |
0.854 | 0.259 | -3 | 0.826 |
CDC7 |
0.854 | 0.115 | 1 | 0.816 |
CDKL1 |
0.853 | 0.227 | -3 | 0.824 |
NDR2 |
0.852 | 0.166 | -3 | 0.833 |
MTOR |
0.851 | 0.129 | 1 | 0.795 |
NLK |
0.851 | 0.196 | 1 | 0.880 |
KIS |
0.850 | 0.205 | 1 | 0.794 |
DYRK2 |
0.850 | 0.287 | 1 | 0.801 |
ERK5 |
0.849 | 0.201 | 1 | 0.886 |
SRPK2 |
0.848 | 0.235 | -3 | 0.716 |
ICK |
0.848 | 0.252 | -3 | 0.848 |
HIPK2 |
0.848 | 0.310 | 1 | 0.727 |
MOS |
0.847 | 0.100 | 1 | 0.849 |
RSK2 |
0.847 | 0.181 | -3 | 0.791 |
PRKD2 |
0.846 | 0.189 | -3 | 0.775 |
MARK4 |
0.846 | 0.234 | 4 | 0.885 |
PRPK |
0.845 | -0.020 | -1 | 0.839 |
SKMLCK |
0.845 | 0.177 | -2 | 0.881 |
PIM1 |
0.844 | 0.199 | -3 | 0.790 |
HIPK1 |
0.843 | 0.309 | 1 | 0.815 |
P90RSK |
0.843 | 0.168 | -3 | 0.793 |
CAMK1B |
0.843 | 0.101 | -3 | 0.840 |
NUAK2 |
0.843 | 0.152 | -3 | 0.822 |
CLK2 |
0.843 | 0.293 | -3 | 0.760 |
ATR |
0.842 | 0.070 | 1 | 0.832 |
RSK3 |
0.842 | 0.155 | -3 | 0.781 |
CDK8 |
0.842 | 0.191 | 1 | 0.757 |
SRPK3 |
0.841 | 0.204 | -3 | 0.758 |
CDK19 |
0.841 | 0.207 | 1 | 0.730 |
NDR1 |
0.841 | 0.099 | -3 | 0.818 |
AMPKA1 |
0.841 | 0.177 | -3 | 0.825 |
IKKB |
0.841 | -0.072 | -2 | 0.742 |
WNK1 |
0.840 | 0.078 | -2 | 0.901 |
AURC |
0.839 | 0.133 | -2 | 0.658 |
CDK18 |
0.839 | 0.241 | 1 | 0.719 |
CDK7 |
0.839 | 0.195 | 1 | 0.773 |
AMPKA2 |
0.838 | 0.184 | -3 | 0.802 |
TSSK1 |
0.838 | 0.198 | -3 | 0.843 |
CDK5 |
0.838 | 0.239 | 1 | 0.792 |
QSK |
0.838 | 0.239 | 4 | 0.870 |
TBK1 |
0.837 | -0.068 | 1 | 0.710 |
PDHK4 |
0.837 | -0.175 | 1 | 0.831 |
CLK1 |
0.837 | 0.239 | -3 | 0.742 |
MAPKAPK2 |
0.837 | 0.149 | -3 | 0.750 |
RAF1 |
0.836 | -0.106 | 1 | 0.815 |
MAPKAPK3 |
0.836 | 0.114 | -3 | 0.774 |
CAMLCK |
0.836 | 0.099 | -2 | 0.845 |
CLK4 |
0.836 | 0.213 | -3 | 0.767 |
CHAK2 |
0.836 | 0.022 | -1 | 0.805 |
MST4 |
0.836 | 0.068 | 2 | 0.800 |
GRK1 |
0.836 | 0.081 | -2 | 0.753 |
CDK1 |
0.836 | 0.212 | 1 | 0.734 |
DAPK2 |
0.835 | 0.122 | -3 | 0.845 |
NIM1 |
0.835 | 0.139 | 3 | 0.765 |
BMPR2 |
0.835 | -0.145 | -2 | 0.849 |
JNK2 |
0.835 | 0.238 | 1 | 0.726 |
DYRK1A |
0.835 | 0.256 | 1 | 0.817 |
NIK |
0.835 | 0.050 | -3 | 0.839 |
ULK2 |
0.834 | -0.123 | 2 | 0.744 |
PKACG |
0.834 | 0.091 | -2 | 0.735 |
GCN2 |
0.834 | -0.173 | 2 | 0.751 |
MAK |
0.834 | 0.351 | -2 | 0.772 |
PKN3 |
0.834 | 0.046 | -3 | 0.812 |
CAMK2D |
0.833 | 0.075 | -3 | 0.819 |
CDK13 |
0.833 | 0.177 | 1 | 0.751 |
HIPK3 |
0.833 | 0.264 | 1 | 0.813 |
TSSK2 |
0.833 | 0.134 | -5 | 0.833 |
PKCD |
0.833 | 0.095 | 2 | 0.722 |
P38B |
0.833 | 0.237 | 1 | 0.756 |
P38A |
0.833 | 0.228 | 1 | 0.814 |
DYRK4 |
0.833 | 0.255 | 1 | 0.736 |
LATS2 |
0.832 | 0.051 | -5 | 0.700 |
PDHK1 |
0.832 | -0.154 | 1 | 0.818 |
NEK6 |
0.832 | -0.032 | -2 | 0.841 |
IKKE |
0.832 | -0.106 | 1 | 0.704 |
JNK3 |
0.832 | 0.215 | 1 | 0.751 |
RSK4 |
0.832 | 0.167 | -3 | 0.769 |
IKKA |
0.831 | -0.001 | -2 | 0.735 |
PKN2 |
0.831 | 0.037 | -3 | 0.805 |
PRKD3 |
0.830 | 0.138 | -3 | 0.749 |
SIK |
0.830 | 0.194 | -3 | 0.754 |
ERK1 |
0.830 | 0.200 | 1 | 0.746 |
P70S6KB |
0.830 | 0.079 | -3 | 0.791 |
CAMK2G |
0.829 | -0.123 | 2 | 0.766 |
FAM20C |
0.829 | 0.150 | 2 | 0.661 |
PKACB |
0.829 | 0.147 | -2 | 0.677 |
DSTYK |
0.829 | -0.140 | 2 | 0.828 |
GRK5 |
0.829 | -0.130 | -3 | 0.818 |
LATS1 |
0.829 | 0.166 | -3 | 0.846 |
DYRK1B |
0.829 | 0.244 | 1 | 0.761 |
MARK3 |
0.829 | 0.210 | 4 | 0.837 |
RIPK3 |
0.828 | -0.105 | 3 | 0.708 |
CDK3 |
0.828 | 0.224 | 1 | 0.686 |
CDK12 |
0.828 | 0.180 | 1 | 0.727 |
QIK |
0.828 | 0.103 | -3 | 0.804 |
P38G |
0.827 | 0.205 | 1 | 0.662 |
TGFBR2 |
0.827 | -0.085 | -2 | 0.719 |
MLK1 |
0.827 | -0.132 | 2 | 0.753 |
CDK17 |
0.827 | 0.198 | 1 | 0.666 |
MNK2 |
0.827 | 0.069 | -2 | 0.798 |
HUNK |
0.826 | -0.084 | 2 | 0.766 |
DYRK3 |
0.826 | 0.235 | 1 | 0.813 |
NEK7 |
0.826 | -0.155 | -3 | 0.812 |
NUAK1 |
0.826 | 0.093 | -3 | 0.774 |
MPSK1 |
0.826 | 0.292 | 1 | 0.809 |
AKT2 |
0.826 | 0.162 | -3 | 0.711 |
PKCB |
0.826 | 0.077 | 2 | 0.669 |
PAK1 |
0.826 | 0.043 | -2 | 0.799 |
BCKDK |
0.825 | -0.134 | -1 | 0.775 |
PKCA |
0.825 | 0.088 | 2 | 0.665 |
MSK2 |
0.825 | 0.084 | -3 | 0.771 |
IRE1 |
0.825 | -0.026 | 1 | 0.789 |
MLK2 |
0.825 | -0.037 | 2 | 0.770 |
CDK9 |
0.825 | 0.158 | 1 | 0.760 |
PIM2 |
0.825 | 0.168 | -3 | 0.756 |
MELK |
0.825 | 0.079 | -3 | 0.783 |
MASTL |
0.824 | -0.140 | -2 | 0.807 |
WNK3 |
0.824 | -0.161 | 1 | 0.795 |
SGK3 |
0.824 | 0.145 | -3 | 0.758 |
PRKX |
0.824 | 0.152 | -3 | 0.689 |
MSK1 |
0.824 | 0.114 | -3 | 0.767 |
CDK14 |
0.824 | 0.211 | 1 | 0.757 |
CAMK2A |
0.824 | 0.081 | 2 | 0.743 |
MARK2 |
0.824 | 0.182 | 4 | 0.804 |
PKG2 |
0.824 | 0.092 | -2 | 0.673 |
PAK3 |
0.823 | 0.016 | -2 | 0.793 |
CAMK2B |
0.823 | 0.063 | 2 | 0.745 |
AURB |
0.823 | 0.076 | -2 | 0.655 |
P38D |
0.822 | 0.223 | 1 | 0.690 |
BRSK1 |
0.822 | 0.101 | -3 | 0.777 |
CDK10 |
0.822 | 0.213 | 1 | 0.746 |
RIPK1 |
0.822 | -0.131 | 1 | 0.796 |
NEK9 |
0.821 | -0.127 | 2 | 0.785 |
PKCG |
0.821 | 0.036 | 2 | 0.664 |
GRK6 |
0.821 | -0.101 | 1 | 0.807 |
MOK |
0.821 | 0.306 | 1 | 0.839 |
BRSK2 |
0.820 | 0.065 | -3 | 0.783 |
MNK1 |
0.820 | 0.061 | -2 | 0.798 |
GRK7 |
0.820 | 0.050 | 1 | 0.751 |
PKR |
0.820 | 0.022 | 1 | 0.832 |
PKCZ |
0.819 | 0.026 | 2 | 0.722 |
VRK2 |
0.819 | 0.024 | 1 | 0.869 |
ULK1 |
0.819 | -0.215 | -3 | 0.766 |
MLK3 |
0.819 | -0.051 | 2 | 0.675 |
CDK2 |
0.819 | 0.114 | 1 | 0.793 |
DLK |
0.819 | -0.180 | 1 | 0.796 |
ERK2 |
0.819 | 0.134 | 1 | 0.776 |
BMPR1B |
0.819 | 0.029 | 1 | 0.775 |
CDK16 |
0.818 | 0.197 | 1 | 0.684 |
ATM |
0.818 | -0.019 | 1 | 0.774 |
SMG1 |
0.817 | -0.007 | 1 | 0.788 |
MARK1 |
0.817 | 0.135 | 4 | 0.848 |
PAK6 |
0.817 | 0.036 | -2 | 0.712 |
MYLK4 |
0.816 | 0.051 | -2 | 0.779 |
SSTK |
0.816 | 0.138 | 4 | 0.851 |
CAMK4 |
0.816 | -0.063 | -3 | 0.788 |
PHKG1 |
0.816 | -0.014 | -3 | 0.803 |
DNAPK |
0.816 | 0.062 | 1 | 0.718 |
ANKRD3 |
0.816 | -0.186 | 1 | 0.836 |
DCAMKL1 |
0.816 | 0.106 | -3 | 0.769 |
GRK4 |
0.816 | -0.170 | -2 | 0.801 |
PAK2 |
0.815 | -0.011 | -2 | 0.776 |
IRE2 |
0.814 | -0.050 | 2 | 0.705 |
PKCH |
0.814 | 0.002 | 2 | 0.662 |
AKT1 |
0.814 | 0.141 | -3 | 0.720 |
PRP4 |
0.813 | 0.074 | -3 | 0.701 |
MEK1 |
0.813 | -0.127 | 2 | 0.803 |
CHAK1 |
0.813 | -0.101 | 2 | 0.736 |
CHK1 |
0.813 | 0.045 | -3 | 0.801 |
PKACA |
0.813 | 0.117 | -2 | 0.627 |
NEK2 |
0.812 | -0.077 | 2 | 0.767 |
TTBK2 |
0.812 | -0.220 | 2 | 0.655 |
TGFBR1 |
0.811 | -0.068 | -2 | 0.724 |
WNK4 |
0.811 | 0.011 | -2 | 0.895 |
ALK4 |
0.811 | -0.121 | -2 | 0.756 |
CAMK1G |
0.810 | 0.048 | -3 | 0.761 |
MAPKAPK5 |
0.810 | -0.005 | -3 | 0.735 |
YSK4 |
0.810 | -0.134 | 1 | 0.740 |
AURA |
0.810 | 0.030 | -2 | 0.626 |
CK1E |
0.809 | 0.009 | -3 | 0.549 |
TLK2 |
0.809 | -0.082 | 1 | 0.772 |
JNK1 |
0.809 | 0.165 | 1 | 0.707 |
MST3 |
0.809 | 0.034 | 2 | 0.776 |
PASK |
0.808 | 0.088 | -3 | 0.859 |
AKT3 |
0.807 | 0.161 | -3 | 0.666 |
PKCT |
0.807 | 0.031 | 2 | 0.671 |
CDK6 |
0.806 | 0.171 | 1 | 0.742 |
IRAK4 |
0.806 | -0.043 | 1 | 0.798 |
BUB1 |
0.806 | 0.201 | -5 | 0.786 |
SNRK |
0.806 | -0.112 | 2 | 0.659 |
MLK4 |
0.806 | -0.144 | 2 | 0.659 |
SGK1 |
0.805 | 0.171 | -3 | 0.648 |
P70S6K |
0.805 | 0.063 | -3 | 0.722 |
ACVR2A |
0.805 | -0.097 | -2 | 0.718 |
NEK5 |
0.805 | -0.038 | 1 | 0.823 |
PLK1 |
0.804 | -0.193 | -2 | 0.751 |
GSK3A |
0.804 | 0.072 | 4 | 0.449 |
ACVR2B |
0.804 | -0.088 | -2 | 0.734 |
PLK4 |
0.803 | -0.087 | 2 | 0.606 |
SMMLCK |
0.803 | 0.030 | -3 | 0.807 |
GAK |
0.803 | 0.120 | 1 | 0.871 |
MEKK2 |
0.803 | -0.079 | 2 | 0.757 |
ERK7 |
0.803 | 0.056 | 2 | 0.486 |
DAPK3 |
0.803 | 0.106 | -3 | 0.791 |
TAO3 |
0.803 | 0.004 | 1 | 0.771 |
MEK5 |
0.802 | -0.200 | 2 | 0.780 |
CAMK1D |
0.802 | 0.089 | -3 | 0.689 |
GRK2 |
0.802 | -0.083 | -2 | 0.699 |
CDK4 |
0.802 | 0.162 | 1 | 0.716 |
PKCE |
0.802 | 0.071 | 2 | 0.655 |
PERK |
0.801 | -0.163 | -2 | 0.773 |
ALK2 |
0.801 | -0.105 | -2 | 0.731 |
PKCI |
0.801 | 0.006 | 2 | 0.688 |
MEKK1 |
0.801 | -0.145 | 1 | 0.792 |
CK1D |
0.801 | 0.005 | -3 | 0.499 |
GSK3B |
0.801 | 0.012 | 4 | 0.441 |
CK1G1 |
0.800 | -0.023 | -3 | 0.535 |
DCAMKL2 |
0.800 | -0.008 | -3 | 0.784 |
PINK1 |
0.800 | -0.137 | 1 | 0.848 |
ZAK |
0.799 | -0.152 | 1 | 0.745 |
BRAF |
0.799 | -0.143 | -4 | 0.745 |
PDK1 |
0.799 | 0.017 | 1 | 0.770 |
SBK |
0.799 | 0.168 | -3 | 0.612 |
ROCK2 |
0.798 | 0.143 | -3 | 0.772 |
DRAK1 |
0.798 | -0.129 | 1 | 0.717 |
PHKG2 |
0.798 | -0.036 | -3 | 0.760 |
HRI |
0.798 | -0.209 | -2 | 0.811 |
MEKK3 |
0.798 | -0.206 | 1 | 0.778 |
LKB1 |
0.797 | -0.003 | -3 | 0.776 |
PLK3 |
0.797 | -0.177 | 2 | 0.724 |
CK1A2 |
0.797 | -0.006 | -3 | 0.501 |
MEKK6 |
0.797 | 0.016 | 1 | 0.788 |
PBK |
0.796 | 0.163 | 1 | 0.818 |
PAK5 |
0.796 | -0.002 | -2 | 0.653 |
TNIK |
0.796 | 0.077 | 3 | 0.877 |
DAPK1 |
0.796 | 0.083 | -3 | 0.781 |
BMPR1A |
0.796 | -0.041 | 1 | 0.748 |
GCK |
0.795 | 0.026 | 1 | 0.780 |
HGK |
0.794 | 0.027 | 3 | 0.871 |
MRCKB |
0.794 | 0.099 | -3 | 0.732 |
MAP3K15 |
0.794 | 0.027 | 1 | 0.735 |
MRCKA |
0.794 | 0.094 | -3 | 0.743 |
PAK4 |
0.794 | 0.007 | -2 | 0.656 |
CAMK1A |
0.793 | 0.104 | -3 | 0.671 |
CHK2 |
0.793 | 0.090 | -3 | 0.653 |
MINK |
0.793 | 0.019 | 1 | 0.773 |
KHS1 |
0.793 | 0.095 | 1 | 0.767 |
TLK1 |
0.793 | -0.195 | -2 | 0.795 |
NEK11 |
0.793 | -0.142 | 1 | 0.764 |
PKN1 |
0.792 | 0.040 | -3 | 0.728 |
TAO2 |
0.792 | -0.084 | 2 | 0.790 |
HPK1 |
0.792 | 0.019 | 1 | 0.768 |
CAMKK2 |
0.791 | -0.103 | -2 | 0.745 |
NEK4 |
0.791 | -0.078 | 1 | 0.784 |
LRRK2 |
0.791 | -0.045 | 2 | 0.798 |
CAMKK1 |
0.790 | -0.174 | -2 | 0.746 |
EEF2K |
0.790 | -0.030 | 3 | 0.842 |
NEK8 |
0.790 | -0.185 | 2 | 0.765 |
DMPK1 |
0.790 | 0.143 | -3 | 0.751 |
KHS2 |
0.789 | 0.078 | 1 | 0.778 |
GRK3 |
0.789 | -0.080 | -2 | 0.652 |
NEK1 |
0.788 | -0.015 | 1 | 0.794 |
MST2 |
0.788 | -0.101 | 1 | 0.788 |
VRK1 |
0.787 | -0.060 | 2 | 0.791 |
CRIK |
0.787 | 0.147 | -3 | 0.734 |
IRAK1 |
0.787 | -0.245 | -1 | 0.728 |
LOK |
0.786 | -0.061 | -2 | 0.754 |
TAK1 |
0.783 | -0.143 | 1 | 0.788 |
TTBK1 |
0.783 | -0.242 | 2 | 0.575 |
PDHK3_TYR |
0.783 | 0.243 | 4 | 0.890 |
ROCK1 |
0.782 | 0.098 | -3 | 0.738 |
YSK1 |
0.781 | -0.043 | 2 | 0.756 |
HASPIN |
0.780 | 0.024 | -1 | 0.686 |
PKG1 |
0.780 | 0.032 | -2 | 0.586 |
CK2A2 |
0.779 | -0.064 | 1 | 0.653 |
MST1 |
0.778 | -0.129 | 1 | 0.768 |
BIKE |
0.778 | 0.130 | 1 | 0.786 |
SLK |
0.778 | -0.116 | -2 | 0.696 |
STK33 |
0.775 | -0.179 | 2 | 0.567 |
PKMYT1_TYR |
0.775 | 0.155 | 3 | 0.838 |
LIMK2_TYR |
0.774 | 0.146 | -3 | 0.844 |
MEK2 |
0.774 | -0.215 | 2 | 0.779 |
PLK2 |
0.774 | -0.102 | -3 | 0.748 |
MAP2K4_TYR |
0.774 | 0.085 | -1 | 0.855 |
NEK3 |
0.773 | -0.110 | 1 | 0.749 |
MYO3B |
0.772 | 0.001 | 2 | 0.774 |
TESK1_TYR |
0.772 | 0.009 | 3 | 0.877 |
OSR1 |
0.771 | -0.081 | 2 | 0.755 |
AAK1 |
0.771 | 0.195 | 1 | 0.707 |
PDHK4_TYR |
0.771 | 0.046 | 2 | 0.828 |
MAP2K6_TYR |
0.770 | 0.006 | -1 | 0.850 |
CK2A1 |
0.768 | -0.081 | 1 | 0.627 |
TTK |
0.768 | -0.091 | -2 | 0.769 |
ASK1 |
0.767 | -0.081 | 1 | 0.717 |
MAP2K7_TYR |
0.767 | -0.123 | 2 | 0.816 |
RIPK2 |
0.767 | -0.301 | 1 | 0.698 |
BMPR2_TYR |
0.766 | -0.024 | -1 | 0.839 |
YANK3 |
0.765 | -0.070 | 2 | 0.356 |
PDHK1_TYR |
0.765 | -0.059 | -1 | 0.846 |
MYO3A |
0.764 | -0.065 | 1 | 0.771 |
CK1A |
0.764 | -0.038 | -3 | 0.414 |
LIMK1_TYR |
0.761 | -0.068 | 2 | 0.812 |
PINK1_TYR |
0.761 | -0.191 | 1 | 0.815 |
TAO1 |
0.760 | -0.106 | 1 | 0.698 |
ALPHAK3 |
0.759 | -0.104 | -1 | 0.724 |
ABL2 |
0.758 | 0.024 | -1 | 0.754 |
ROS1 |
0.758 | -0.054 | 3 | 0.753 |
EPHA6 |
0.757 | -0.025 | -1 | 0.786 |
RET |
0.757 | -0.131 | 1 | 0.788 |
ABL1 |
0.757 | 0.023 | -1 | 0.750 |
FGR |
0.756 | -0.024 | 1 | 0.855 |
TYRO3 |
0.756 | -0.104 | 3 | 0.781 |
YES1 |
0.756 | -0.019 | -1 | 0.820 |
EPHB4 |
0.756 | -0.048 | -1 | 0.762 |
TYK2 |
0.756 | -0.143 | 1 | 0.788 |
JAK2 |
0.755 | -0.100 | 1 | 0.787 |
MST1R |
0.753 | -0.162 | 3 | 0.779 |
TNK2 |
0.753 | -0.004 | 3 | 0.710 |
TXK |
0.753 | 0.002 | 1 | 0.807 |
LCK |
0.752 | 0.030 | -1 | 0.794 |
TNNI3K_TYR |
0.752 | 0.024 | 1 | 0.814 |
TNK1 |
0.751 | -0.010 | 3 | 0.760 |
CSF1R |
0.751 | -0.121 | 3 | 0.759 |
HCK |
0.751 | -0.045 | -1 | 0.794 |
DDR1 |
0.750 | -0.157 | 4 | 0.824 |
BLK |
0.750 | 0.043 | -1 | 0.793 |
FER |
0.748 | -0.145 | 1 | 0.857 |
ITK |
0.748 | -0.072 | -1 | 0.757 |
JAK1 |
0.747 | -0.031 | 1 | 0.722 |
STLK3 |
0.746 | -0.229 | 1 | 0.713 |
JAK3 |
0.745 | -0.179 | 1 | 0.752 |
SRMS |
0.745 | -0.119 | 1 | 0.829 |
NEK10_TYR |
0.745 | -0.096 | 1 | 0.649 |
FYN |
0.744 | 0.012 | -1 | 0.784 |
INSRR |
0.743 | -0.169 | 3 | 0.713 |
EPHA4 |
0.742 | -0.112 | 2 | 0.724 |
EPHB1 |
0.742 | -0.144 | 1 | 0.825 |
MERTK |
0.742 | -0.105 | 3 | 0.737 |
BMX |
0.741 | -0.076 | -1 | 0.678 |
EPHB2 |
0.740 | -0.107 | -1 | 0.733 |
EPHB3 |
0.740 | -0.133 | -1 | 0.740 |
PDGFRB |
0.739 | -0.229 | 3 | 0.774 |
KDR |
0.739 | -0.175 | 3 | 0.712 |
KIT |
0.738 | -0.204 | 3 | 0.757 |
WEE1_TYR |
0.738 | -0.117 | -1 | 0.715 |
FGFR2 |
0.738 | -0.228 | 3 | 0.757 |
AXL |
0.738 | -0.174 | 3 | 0.730 |
TEK |
0.737 | -0.195 | 3 | 0.703 |
BTK |
0.737 | -0.200 | -1 | 0.727 |
FLT3 |
0.737 | -0.231 | 3 | 0.773 |
DDR2 |
0.736 | -0.043 | 3 | 0.692 |
TEC |
0.736 | -0.146 | -1 | 0.691 |
ALK |
0.736 | -0.164 | 3 | 0.687 |
MET |
0.735 | -0.171 | 3 | 0.746 |
CK1G3 |
0.735 | -0.072 | -3 | 0.368 |
PTK6 |
0.735 | -0.209 | -1 | 0.683 |
LTK |
0.735 | -0.148 | 3 | 0.706 |
FGFR1 |
0.734 | -0.225 | 3 | 0.722 |
LYN |
0.733 | -0.098 | 3 | 0.678 |
PDGFRA |
0.733 | -0.267 | 3 | 0.780 |
SRC |
0.731 | -0.076 | -1 | 0.778 |
EPHA1 |
0.731 | -0.153 | 3 | 0.714 |
EPHA7 |
0.730 | -0.143 | 2 | 0.725 |
YANK2 |
0.730 | -0.105 | 2 | 0.373 |
PTK2B |
0.729 | -0.106 | -1 | 0.730 |
FRK |
0.729 | -0.167 | -1 | 0.774 |
EPHA3 |
0.728 | -0.197 | 2 | 0.697 |
INSR |
0.727 | -0.212 | 3 | 0.687 |
NTRK1 |
0.726 | -0.294 | -1 | 0.762 |
FGFR3 |
0.724 | -0.257 | 3 | 0.719 |
FLT1 |
0.723 | -0.255 | -1 | 0.756 |
ERBB2 |
0.723 | -0.269 | 1 | 0.727 |
NTRK2 |
0.722 | -0.305 | 3 | 0.717 |
MATK |
0.722 | -0.187 | -1 | 0.670 |
NTRK3 |
0.721 | -0.223 | -1 | 0.711 |
EPHA5 |
0.720 | -0.175 | 2 | 0.712 |
PTK2 |
0.720 | -0.072 | -1 | 0.739 |
SYK |
0.719 | -0.083 | -1 | 0.711 |
FLT4 |
0.718 | -0.315 | 3 | 0.711 |
EPHA8 |
0.717 | -0.180 | -1 | 0.725 |
CSK |
0.717 | -0.220 | 2 | 0.730 |
EGFR |
0.717 | -0.172 | 1 | 0.636 |
CK1G2 |
0.714 | -0.089 | -3 | 0.455 |
FGFR4 |
0.712 | -0.211 | -1 | 0.699 |
IGF1R |
0.709 | -0.225 | 3 | 0.626 |
EPHA2 |
0.708 | -0.186 | -1 | 0.691 |
MUSK |
0.707 | -0.215 | 1 | 0.632 |
ERBB4 |
0.705 | -0.144 | 1 | 0.661 |
ZAP70 |
0.701 | -0.091 | -1 | 0.657 |
FES |
0.699 | -0.207 | -1 | 0.656 |