Motif 186 (n=315)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A1W2PPC1	PRR33	S207	ochoa	Proline rich 33	None
A1X283	SH3PXD2B	T768	ochoa	SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)	Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12615925, ECO:0000269\|PubMed:19755710, ECO:0000269\|PubMed:20609497}.
A7MCY6	TBKBP1	S372	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
A7MCY6	TBKBP1	S388	ochoa	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269\|PubMed:21931631}.
A8MZF0	PRR33	S59	ochoa	Proline-rich protein 33	None
B8ZZF3	None	S342	ochoa	Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256\|ARBA:ARBA00057523}.
E9PAV3	NACA	S1429	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
E9PAV3	NACA	S1488	ochoa	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)	Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250\|UniProtKB:P70670}.
K7EQG2	None	S39	ochoa	Uncharacterized protein	None
O00330	PDHX	S162	ochoa	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.
O14497	ARID1A	S705	ochoa	AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250\|UniProtKB:A2BH40, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
O14545	TRAFD1	S491	ochoa	TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)	Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16221674}.
O14578	CIT	S1954	ochoa	Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)	Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. {ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:16431929, ECO:0000269\|PubMed:21457715, ECO:0000269\|PubMed:27453578}.
O14641	DVL2	S131	ochoa	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250\|UniProtKB:Q60838, ECO:0000269\|PubMed:19252499, ECO:0000269\|PubMed:24616100}.
O14686	KMT2D	S2251	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14686	KMT2D	S2260	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14686	KMT2D	S4327	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O15047	SETD1A	S450	ochoa	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250\|UniProtKB:E9PYH6, ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:25561738, ECO:0000269\|PubMed:29937342, ECO:0000269\|PubMed:31197650, ECO:0000269\|PubMed:32346159, ECO:0000269\|PubMed:38003223}.
O15063	GARRE1	S723	ochoa	Granule associated Rac and RHOG effector protein 1 (GARRE1)	Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269\|PubMed:29395067, ECO:0000269\|PubMed:31871319}.
O15231	ZNF185	S455	ochoa	Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)	May be involved in the regulation of cellular proliferation and/or differentiation.
O15231	ZNF185	S521	ochoa	Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)	May be involved in the regulation of cellular proliferation and/or differentiation.
O15357	INPPL1	S1011	ochoa	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250\|UniProtKB:F1PNY0, ECO:0000250\|UniProtKB:Q6P549, ECO:0000250\|UniProtKB:Q9WVR3, ECO:0000269\|PubMed:11016922, ECO:0000269\|PubMed:11349134, ECO:0000269\|PubMed:11739414, ECO:0000269\|PubMed:12235291, ECO:0000269\|PubMed:12676785, ECO:0000269\|PubMed:12690104, ECO:0000269\|PubMed:15668240, ECO:0000269\|PubMed:15735664, ECO:0000269\|PubMed:16824732, ECO:0000269\|PubMed:17135240, ECO:0000269\|PubMed:21624956, ECO:0000269\|PubMed:23273569, ECO:0000269\|PubMed:9660833}.
O43149	ZZEF1	S1499	ochoa	Zinc finger ZZ-type and EF-hand domain-containing protein 1	Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269\|PubMed:33227311}.
O43295	SRGAP3	S1069	ochoa	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)	GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269\|PubMed:12195014, ECO:0000269\|PubMed:12447388}.
O43295	SRGAP3	S1072	ochoa	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)	GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. {ECO:0000269\|PubMed:12195014, ECO:0000269\|PubMed:12447388}.
O43312	MTSS1	S644	ochoa	Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)	May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
O43896	KIF1C	S1033	ochoa	Kinesin-like protein KIF1C	Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269\|PubMed:9685376}.
O60244	MED14	S1142	ochoa	Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:15340088, ECO:0000269\|PubMed:15625066, ECO:0000269\|PubMed:16595664}.
O60269	GPRIN2	S26	ochoa	G protein-regulated inducer of neurite outgrowth 2 (GRIN2)	May be involved in neurite outgrowth. {ECO:0000269\|PubMed:10480904}.
O60291	MGRN1	S471	ochoa	E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250\|UniProtKB:Q9D074, ECO:0000269\|PubMed:17229889, ECO:0000269\|PubMed:19703557, ECO:0000269\|PubMed:19737927}.
O60336	MAPKBP1	S1254	ochoa	Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)	Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q6NS57, ECO:0000269\|PubMed:22700971}.
O60341	KDM1A	S80	ochoa	Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)	Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269\|PubMed:12032298, ECO:0000269\|PubMed:15620353, ECO:0000269\|PubMed:15811342, ECO:0000269\|PubMed:16079794, ECO:0000269\|PubMed:16079795, ECO:0000269\|PubMed:16140033, ECO:0000269\|PubMed:16223729, ECO:0000269\|PubMed:16885027, ECO:0000269\|PubMed:16956976, ECO:0000269\|PubMed:17805299, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:20562920, ECO:0000269\|PubMed:21300290, ECO:0000269\|PubMed:23721412, ECO:0000269\|PubMed:27292636, ECO:0000269\|PubMed:29358331, ECO:0000269\|PubMed:29691401, ECO:0000269\|PubMed:34655521, ECO:0000269\|PubMed:34906447}.
O60732	MAGEC1	S207	ochoa	Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen)	None
O60885	BRD4	S484	psp	Bromodomain-containing protein 4 (Protein HUNK1)	Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250\|UniProtKB:Q9ESU6, ECO:0000269\|PubMed:16109376, ECO:0000269\|PubMed:16109377, ECO:0000269\|PubMed:19103749, ECO:0000269\|PubMed:19596240, ECO:0000269\|PubMed:22334664, ECO:0000269\|PubMed:22509028, ECO:0000269\|PubMed:23086925, ECO:0000269\|PubMed:23317504, ECO:0000269\|PubMed:23589332, ECO:0000269\|PubMed:24360279, ECO:0000269\|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269\|PubMed:23728299}.
O60936	NOL3	S120	ochoa	Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30)	[Isoform 1]: May be involved in RNA splicing. {ECO:0000269\|PubMed:10196175}.; FUNCTION: [Isoform 2]: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (By similarity). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (By similarity). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250\|UniProtKB:Q62881, ECO:0000250\|UniProtKB:Q9D1X0, ECO:0000269\|PubMed:15004034, ECO:0000269\|PubMed:15509781}.
O75064	DENND4B	S1092	ochoa	DENN domain-containing protein 4B	Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269\|PubMed:20937701}.
O75152	ZC3H11A	S116	ochoa	Zinc finger CCCH domain-containing protein 11A	Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269\|PubMed:22928037, ECO:0000269\|PubMed:29610341, ECO:0000269\|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269\|PubMed:29610341, ECO:0000269\|PubMed:37356722}.
O75161	NPHP4	S510	ochoa	Nephrocystin-4 (Nephroretinin)	Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250\|UniProtKB:B0DOB4, ECO:0000250\|UniProtKB:P59240, ECO:0000269\|PubMed:21498478, ECO:0000269\|PubMed:21555462, ECO:0000269\|PubMed:21565611, ECO:0000269\|PubMed:22654112, ECO:0000305\|PubMed:19755384}.
O75179	ANKRD17	S2056	ochoa	Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)	Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250\|UniProtKB:Q99NH0, ECO:0000269\|PubMed:17276651, ECO:0000269\|PubMed:19150984, ECO:0000269\|PubMed:22328336, ECO:0000269\|PubMed:23711367}.
O75362	ZNF217	S980	ochoa	Zinc finger protein 217	Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269\|PubMed:16203743, ECO:0000269\|PubMed:16940172, ECO:0000269\|PubMed:17259635, ECO:0000269\|PubMed:18625718}.
O75533	SF3B1	S259	ochoa	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250\|UniProtKB:Q99NB9, ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
O75694	NUP155	S1006	ochoa	Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)	Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250\|UniProtKB:Q99P88}.
O75909	CCNK	S340	ochoa	Cyclin-K	Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269\|PubMed:10574912, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:9632813}.
O75925	PIAS1	S517	ochoa	E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250\|UniProtKB:O88907, ECO:0000269\|PubMed:11583632, ECO:0000269\|PubMed:11867732, ECO:0000269\|PubMed:14500712, ECO:0000269\|PubMed:15133049, ECO:0000269\|PubMed:21965678, ECO:0000269\|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269\|PubMed:29262325}.
O75925	PIAS1	S522	psp	E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2 and PML (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway (PubMed:11583632, PubMed:11867732). In vitro, binds A/T-rich DNA (PubMed:15133049). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context (PubMed:11583632, PubMed:11867732, PubMed:14500712, PubMed:21965678, PubMed:36050397). Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection (PubMed:36050397). Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678). Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes (By similarity). Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumoylation activity (By similarity). Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter (By similarity). {ECO:0000250\|UniProtKB:O88907, ECO:0000269\|PubMed:11583632, ECO:0000269\|PubMed:11867732, ECO:0000269\|PubMed:14500712, ECO:0000269\|PubMed:15133049, ECO:0000269\|PubMed:21965678, ECO:0000269\|PubMed:36050397}.; FUNCTION: (Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325). The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325). {ECO:0000269\|PubMed:29262325}.
O94811	TPPP	S32	ochoa\|psp	Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)	Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514). {ECO:0000269\|PubMed:17105200, ECO:0000269\|PubMed:17693641, ECO:0000269\|PubMed:18028908, ECO:0000269\|PubMed:20308065, ECO:0000269\|PubMed:21316364, ECO:0000269\|PubMed:21995432, ECO:0000269\|PubMed:22328514, ECO:0000269\|PubMed:23093407, ECO:0000269\|PubMed:23355470, ECO:0000269\|PubMed:26289831, ECO:0000269\|PubMed:31522887}.
O94868	FCHSD2	Y667	ochoa	F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)	Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269\|PubMed:29887380, ECO:0000269\|PubMed:30249660}.
O94885	SASH1	S1062	ochoa	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)	Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269\|PubMed:23333244, ECO:0000269\|PubMed:23776175, ECO:0000269\|PubMed:25315659}.
O94887	FARP2	S473	ochoa	FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)	Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.
O95049	TJP3	S323	ochoa	Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250\|UniProtKB:O62683, ECO:0000250\|UniProtKB:Q9QXY1, ECO:0000269\|PubMed:16129888, ECO:0000269\|PubMed:21411630}.
O95155	UBE4B	S50	ochoa	Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)	Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250\|UniProtKB:P54860, ECO:0000250\|UniProtKB:Q9ES00, ECO:0000269\|PubMed:17369820}.
O95382	MAP3K6	T968	ochoa	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)	Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269\|PubMed:17210579, ECO:0000269\|PubMed:9875215}.
O95382	MAP3K6	S969	ochoa	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)	Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269\|PubMed:17210579, ECO:0000269\|PubMed:9875215}.
O95402	MED26	S334	ochoa	Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95863	SNAI1	S115	psp	Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250\|UniProtKB:Q02085, ECO:0000269\|PubMed:10655587, ECO:0000269\|PubMed:15647282, ECO:0000269\|PubMed:16096638, ECO:0000269\|PubMed:20121949, ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:20562920, ECO:0000269\|PubMed:21300290, ECO:0000269\|PubMed:21952048, ECO:0000269\|PubMed:23721412, ECO:0000269\|PubMed:25827072}.
P04792	HSPB1	S49	ochoa	Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269\|PubMed:10383393, ECO:0000269\|PubMed:19166925, ECO:0000269\|PubMed:20178975, ECO:0000269\|PubMed:23728742}.
P0C1Z6	TFPT	S188	ochoa	TCF3 fusion partner (INO80 complex subunit F) (Protein FB1)	Appears to promote apoptosis in a p53/TP53-independent manner.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
P10636	MAPT	S341	ochoa	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
P14209	CD99	S85	ochoa	CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)	Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). {ECO:0000250}.
P14598	NCF1	S359	psp	Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)	Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269\|PubMed:12732142, ECO:0000269\|PubMed:19801500, ECO:0000269\|PubMed:2547247, ECO:0000269\|PubMed:2550933, ECO:0000269\|PubMed:38355798}.
P15884	TCF4	T191	ochoa	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. {ECO:0000250}.
P16284	PECAM1	S653	ochoa	Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250\|UniProtKB:Q08481, ECO:0000269\|PubMed:12110892, ECO:0000269\|PubMed:17580308, ECO:0000269\|PubMed:18672896, ECO:0000269\|PubMed:19342684, ECO:0000269\|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269\|PubMed:18388311}.
P17600	SYN1	S553	ochoa\|psp	Synapsin-1 (Brain protein 4.1) (Synapsin I)	Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250\|UniProtKB:O88935, ECO:0000250\|UniProtKB:P09951, ECO:0000269\|PubMed:21441247, ECO:0000269\|PubMed:23406870}.
P17947	SPI1	S112	ochoa	Transcription factor PU.1 (31 kDa-transforming protein)	Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250\|UniProtKB:P17433, ECO:0000250\|UniProtKB:Q6BDS1, ECO:0000269\|PubMed:23658224, ECO:0000269\|PubMed:33951726}.
P18887	XRCC1	S219	ochoa	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269\|PubMed:11163244, ECO:0000269\|PubMed:14500814, ECO:0000269\|PubMed:28002403, ECO:0000269\|PubMed:34102106, ECO:0000269\|PubMed:34811483}.
P18887	XRCC1	S461	ochoa\|psp	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403, PubMed:34102106, PubMed:34811483). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483). {ECO:0000269\|PubMed:11163244, ECO:0000269\|PubMed:14500814, ECO:0000269\|PubMed:28002403, ECO:0000269\|PubMed:34102106, ECO:0000269\|PubMed:34811483}.
P20749	BCL3	S122	psp	B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)	Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8453667}.
P24928	POLR2A	S1847	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	T1854	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1861	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1868	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1875	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1882	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1889	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1896	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	T1903	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1910	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1917	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1924	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1931	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1938	ochoa	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P27448	MARK3	S594	ochoa	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269\|PubMed:12941695, ECO:0000269\|PubMed:16822840, ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:28087714}.
P27708	CAD	T1831	ochoa	Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]	Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269\|PubMed:24332717}.
P29536	LMOD1	S553	ochoa	Leiomodin-1 (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (64 kDa autoantigen D1) (Leiomodin, muscle form) (Smooth muscle leiomodin) (SM-Lmod) (Thyroid-associated ophthalmopathy autoantigen)	Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments. {ECO:0000269\|PubMed:26370058, ECO:0000269\|PubMed:28292896}.
P35568	IRS1	S766	ochoa	Insulin receptor substrate 1 (IRS-1)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:11171109, ECO:0000269\|PubMed:16878150, ECO:0000269\|PubMed:19639489, ECO:0000269\|PubMed:38625937, ECO:0000269\|PubMed:7541045, ECO:0000269\|PubMed:8265614}.
P37275	ZEB1	S572	ochoa	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250\|UniProtKB:Q64318, ECO:0000269\|PubMed:19935649, ECO:0000269\|PubMed:20175752, ECO:0000269\|PubMed:20418909}.
P41231	P2RY2	S341	ochoa	P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)	Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
P41235	HNF4A	S443	psp	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)	Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250\|UniProtKB:P49698, ECO:0000269\|PubMed:30530698, ECO:0000269\|PubMed:30597922}.
P46108	CRK	S85	ochoa	Adapter molecule crk (Proto-oncogene c-Crk) (p38)	Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269\|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250\|UniProtKB:Q64010, ECO:0000269\|PubMed:11870224, ECO:0000269\|PubMed:1630456, ECO:0000269\|PubMed:17515907, ECO:0000269\|PubMed:19004829, ECO:0000269\|PubMed:31311869}.
P46379	BAG6	S964	ochoa	Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)	ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:27193484, PubMed:28104892). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250\|UniProtKB:Q9Z1R2, ECO:0000269\|PubMed:20516149, ECO:0000269\|PubMed:20676083, ECO:0000269\|PubMed:21636303, ECO:0000269\|PubMed:21743475, ECO:0000269\|PubMed:23129660, ECO:0000269\|PubMed:24981174, ECO:0000269\|PubMed:25179605, ECO:0000269\|PubMed:26565908, ECO:0000269\|PubMed:26692333, ECO:0000269\|PubMed:27193484, ECO:0000269\|PubMed:28104892}.; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). {ECO:0000269\|PubMed:17403783, ECO:0000269\|PubMed:18765639}.; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). {ECO:0000269\|PubMed:18055229, ECO:0000269\|PubMed:18852879}.; FUNCTION: Mediates ricin-induced apoptosis. {ECO:0000269\|PubMed:14960581}.
P46937	YAP1	S105	ochoa	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P46937	YAP1	S300	ochoa	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P47974	ZFP36L2	S438	ochoa	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250\|UniProtKB:P23949, ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496, ECO:0000269\|PubMed:25106868, ECO:0000269\|PubMed:34611029}.
P48634	PRRC2A	S146	ochoa	Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)	May play a role in the regulation of pre-mRNA splicing. {ECO:0000269\|PubMed:14667819}.
P48634	PRRC2A	S1089	ochoa	Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)	May play a role in the regulation of pre-mRNA splicing. {ECO:0000269\|PubMed:14667819}.
P49023	PXN	S340	ochoa	Paxillin	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269\|PubMed:25015296}.
P49674	CSNK1E	S343	ochoa	Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250\|UniProtKB:Q9JMK2, ECO:0000269\|PubMed:12556519, ECO:0000269\|PubMed:15070676, ECO:0000269\|PubMed:15917222, ECO:0000269\|PubMed:16790549, ECO:0000269\|PubMed:23413191, ECO:0000305\|PubMed:7797465}.
P49757	NUMB	S252	ochoa	Protein numb homolog (h-Numb) (Protein S171)	Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250\|UniProtKB:Q9QZS3, ECO:0000269\|PubMed:18657069}.
P50219	MNX1	S79	ochoa	Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)	Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity). {ECO:0000250\|UniProtKB:Q9QZW9}.
P50548	ERF	S368	ochoa	ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)	Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.
P51825	AFF1	S588	ochoa	AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)	None
P54259	ATN1	S168	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P54259	ATN1	S182	ochoa	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)	Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250\|UniProtKB:O35126, ECO:0000269\|PubMed:10085113, ECO:0000269\|PubMed:10973986}.
P55198	MLLT6	S279	ochoa	Protein AF-17 (ALL1-fused gene from chromosome 17 protein)	None
P78310	CXADR	S346	ochoa	Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)	Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269\|PubMed:11734628, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:15800062, ECO:0000269\|PubMed:19064666, ECO:0000269\|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269\|PubMed:10567268, ECO:0000269\|PubMed:10666333, ECO:0000269\|PubMed:12297051, ECO:0000269\|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269\|PubMed:10814575, ECO:0000269\|PubMed:14978041}.
P78312	FAM193A	S383	ochoa	Protein FAM193A (Protein IT14)	None
P78314	SH3BP2	S225	ochoa\|psp	SH3 domain-binding protein 2 (3BP-2)	Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
P78559	MAP1A	S1812	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P85037	FOXK1	S431	ochoa	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250\|UniProtKB:P42128, ECO:0000269\|PubMed:17670796, ECO:0000269\|PubMed:24634419, ECO:0000269\|PubMed:25805136, ECO:0000269\|PubMed:25852164, ECO:0000269\|PubMed:30664650}.
P98164	LRP2	S4627	psp	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity). {ECO:0000250\|UniProtKB:A2ARV4, ECO:0000250\|UniProtKB:C0HL13, ECO:0000250\|UniProtKB:P98158, ECO:0000269\|PubMed:15126248, ECO:0000269\|PubMed:23825075}.
Q00613	HSF1	S314	ochoa\|psp	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)	Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269\|PubMed:10359787, ECO:0000269\|PubMed:11447121, ECO:0000269\|PubMed:11583998, ECO:0000269\|PubMed:12659875, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:14707147, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:16278218, ECO:0000269\|PubMed:17897941, ECO:0000269\|PubMed:18451878, ECO:0000269\|PubMed:1871105, ECO:0000269\|PubMed:18794143, ECO:0000269\|PubMed:1986252, ECO:0000269\|PubMed:25963659, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:26727489, ECO:0000269\|PubMed:26754925, ECO:0000269\|PubMed:34723967, ECO:0000269\|PubMed:7623826, ECO:0000269\|PubMed:7760831, ECO:0000269\|PubMed:7935471, ECO:0000269\|PubMed:8455624, ECO:0000269\|PubMed:8940068, ECO:0000269\|PubMed:8946918, ECO:0000269\|PubMed:9121459, ECO:0000269\|PubMed:9341107, ECO:0000269\|PubMed:9499401, ECO:0000269\|PubMed:9535852, ECO:0000269\|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269\|PubMed:27189267}.
Q01167	FOXK2	S384	ochoa	Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)	Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250\|UniProtKB:Q3UCQ1, ECO:0000269\|PubMed:1339390, ECO:0000269\|PubMed:1909027, ECO:0000269\|PubMed:20097901, ECO:0000269\|PubMed:22083952, ECO:0000269\|PubMed:24634419, ECO:0000269\|PubMed:25451922, ECO:0000269\|PubMed:25805136, ECO:0000269\|PubMed:30664650}.
Q02952	AKAP12	S371	ochoa	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164	KMT2A	S2508	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q03164	KMT2A	S3050	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q03164	KMT2A	S3529	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q04323	UBXN1	S202	ochoa	UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)	Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Also prevents the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. {ECO:0000269\|PubMed:20351172, ECO:0000269\|PubMed:23545497, ECO:0000269\|PubMed:25681446, ECO:0000269\|PubMed:28152074}.
Q05397	PTK2	S892	ochoa	Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)	Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269\|PubMed:10655584, ECO:0000269\|PubMed:11331870, ECO:0000269\|PubMed:11980671, ECO:0000269\|PubMed:15166238, ECO:0000269\|PubMed:15561106, ECO:0000269\|PubMed:15895076, ECO:0000269\|PubMed:16919435, ECO:0000269\|PubMed:16927379, ECO:0000269\|PubMed:17395594, ECO:0000269\|PubMed:17431114, ECO:0000269\|PubMed:17968709, ECO:0000269\|PubMed:18006843, ECO:0000269\|PubMed:18206965, ECO:0000269\|PubMed:18256281, ECO:0000269\|PubMed:18292575, ECO:0000269\|PubMed:18497331, ECO:0000269\|PubMed:18677107, ECO:0000269\|PubMed:19138410, ECO:0000269\|PubMed:19147981, ECO:0000269\|PubMed:19224453, ECO:0000269\|PubMed:20332118, ECO:0000269\|PubMed:20495381, ECO:0000269\|PubMed:21454698, ECO:0000269\|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269\|PubMed:20109444}.
Q07157	TJP1	S919	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07889	SOS1	S1193	psp	Son of sevenless homolog 1 (SOS-1)	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250\|UniProtKB:Q62245, ECO:0000269\|PubMed:17339331, ECO:0000269\|PubMed:8493579}.
Q07889	SOS1	S1197	psp	Son of sevenless homolog 1 (SOS-1)	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250\|UniProtKB:Q62245, ECO:0000269\|PubMed:17339331, ECO:0000269\|PubMed:8493579}.
Q07889	SOS1	S1229	ochoa	Son of sevenless homolog 1 (SOS-1)	Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250\|UniProtKB:Q62245, ECO:0000269\|PubMed:17339331, ECO:0000269\|PubMed:8493579}.
Q08211	DHX9	S125	ochoa	ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)	Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250\|UniProtKB:O70133, ECO:0000269\|PubMed:10198287, ECO:0000269\|PubMed:10924507, ECO:0000269\|PubMed:11038348, ECO:0000269\|PubMed:11149922, ECO:0000269\|PubMed:11402034, ECO:0000269\|PubMed:11416126, ECO:0000269\|PubMed:11687588, ECO:0000269\|PubMed:12711669, ECO:0000269\|PubMed:15355351, ECO:0000269\|PubMed:1537828, ECO:0000269\|PubMed:16680162, ECO:0000269\|PubMed:17531811, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:20669935, ECO:0000269\|PubMed:21247876, ECO:0000269\|PubMed:21561811, ECO:0000269\|PubMed:22190748, ECO:0000269\|PubMed:24049074, ECO:0000269\|PubMed:24990949, ECO:0000269\|PubMed:25062910, ECO:0000269\|PubMed:28221134, ECO:0000269\|PubMed:28355180, ECO:0000269\|PubMed:28636595, ECO:0000269\|PubMed:37467750, ECO:0000269\|PubMed:9111062, ECO:0000269\|PubMed:9162007, ECO:0000269\|PubMed:9323138, ECO:0000269\|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269\|PubMed:11096080, ECO:0000269\|PubMed:16680162, ECO:0000269\|PubMed:19229320, ECO:0000269\|PubMed:20696886, ECO:0000269\|PubMed:21957149, ECO:0000269\|PubMed:25149208, ECO:0000269\|PubMed:27107641, ECO:0000269\|PubMed:9892698}.
Q08AD1	CAMSAP2	S1290	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q12774	ARHGEF5	S1004	ochoa	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250\|UniProtKB:E9Q7D5, ECO:0000269\|PubMed:14662653, ECO:0000269\|PubMed:15601624}.
Q12802	AKAP13	S2720	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q13191	CBLB	S793	ochoa	E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250\|UniProtKB:Q3TTA7, ECO:0000269\|PubMed:10022120, ECO:0000269\|PubMed:10086340, ECO:0000269\|PubMed:11087752, ECO:0000269\|PubMed:11526404, ECO:0000269\|PubMed:14661060, ECO:0000269\|PubMed:20525694}.
Q13263	TRIM28	S439	ochoa	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)	Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250\|UniProtKB:Q62318, ECO:0000269\|PubMed:10347202, ECO:0000269\|PubMed:11959841, ECO:0000269\|PubMed:15882967, ECO:0000269\|PubMed:16107876, ECO:0000269\|PubMed:16862143, ECO:0000269\|PubMed:17079232, ECO:0000269\|PubMed:17178852, ECO:0000269\|PubMed:17704056, ECO:0000269\|PubMed:17942393, ECO:0000269\|PubMed:18060868, ECO:0000269\|PubMed:18082607, ECO:0000269\|PubMed:20424263, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:20864041, ECO:0000269\|PubMed:21940674, ECO:0000269\|PubMed:23543754, ECO:0000269\|PubMed:23665872, ECO:0000269\|PubMed:24623306, ECO:0000269\|PubMed:27029610, ECO:0000269\|PubMed:8769649, ECO:0000269\|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269\|PubMed:24741090}.
Q13330	MTA1	S562	ochoa	Metastasis-associated protein MTA1	Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250\|UniProtKB:Q8K4B0, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:17671180, ECO:0000269\|PubMed:17922032, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:21965678, ECO:0000269\|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269\|PubMed:15077195}.
Q13470	TNK1	S543	ochoa	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)	Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269\|PubMed:10873601, ECO:0000269\|PubMed:18974114}.
Q13487	SNAPC2	S192	ochoa	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (Proximal sequence element-binding transcription factor subunit delta) (PSE-binding factor subunit delta) (PTF subunit delta) (Small nuclear RNA-activating complex polypeptide 2) (snRNA-activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit)	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Q13501	SQSTM1	S283	ochoa	Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)	Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250\|UniProtKB:Q64337, ECO:0000269\|PubMed:10356400, ECO:0000269\|PubMed:10747026, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:12471037, ECO:0000269\|PubMed:15340068, ECO:0000269\|PubMed:15802564, ECO:0000269\|PubMed:15911346, ECO:0000269\|PubMed:15953362, ECO:0000269\|PubMed:16079148, ECO:0000269\|PubMed:16286508, ECO:0000269\|PubMed:17580304, ECO:0000269\|PubMed:19931284, ECO:0000269\|PubMed:20168092, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:22017874, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:24128730, ECO:0000269\|PubMed:25101860, ECO:0000269\|PubMed:26344566, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:28404643, ECO:0000269\|PubMed:29343546, ECO:0000269\|PubMed:29496741, ECO:0000269\|PubMed:29507397, ECO:0000269\|PubMed:31857589, ECO:0000269\|PubMed:33393215, ECO:0000269\|PubMed:33472082, ECO:0000269\|PubMed:33509017, ECO:0000269\|PubMed:34471133, ECO:0000269\|PubMed:34893540, ECO:0000269\|PubMed:35831301, ECO:0000269\|PubMed:37306101, ECO:0000269\|PubMed:37802024}.
Q13796	SHROOM2	S433	ochoa	Protein Shroom2 (Apical-like protein) (Protein APXL)	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13938	CAPS	S40	ochoa	Calcyphosin (Calcyphosine)	Calcium-binding protein. May play a role in cellular signaling events (Potential). {ECO:0000305}.
Q14008	CKAP5	S830	ochoa	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)	Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269\|PubMed:12569123, ECO:0000269\|PubMed:18809577, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:21646404, ECO:0000269\|PubMed:23532825, ECO:0000269\|PubMed:27156448, ECO:0000269\|PubMed:9570755}.
Q14160	SCRIB	S1353	ochoa	Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)	Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250\|UniProtKB:A0A8P0N4K0, ECO:0000250\|UniProtKB:Q80U72, ECO:0000269\|PubMed:15182672, ECO:0000269\|PubMed:16344308, ECO:0000269\|PubMed:16965391, ECO:0000269\|PubMed:18641685, ECO:0000269\|PubMed:18716323, ECO:0000269\|PubMed:19041750, ECO:0000269\|PubMed:27380321}.
Q14162	SCARF1	S742	ochoa	Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)	Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}.
Q14244	MAP7	S353	ochoa	Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7)	Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269\|PubMed:11719555, ECO:0000269\|PubMed:8408219, ECO:0000269\|PubMed:9989799}.
Q14469	HES1	S38	psp	Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)	Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269\|PubMed:18550849}.
Q14493	SLBP	S182	ochoa	Histone RNA hairpin-binding protein (Histone stem-loop-binding protein)	RNA-binding protein involved in the histone pre-mRNA processing (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (PubMed:12588979, PubMed:19155325, PubMed:8957003, PubMed:9049306). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity). {ECO:0000250\|UniProtKB:P97440, ECO:0000269\|PubMed:12588979, ECO:0000269\|PubMed:19155325, ECO:0000269\|PubMed:8957003, ECO:0000269\|PubMed:9049306}.
Q14511	NEDD9	S312	ochoa	Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]	Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250\|UniProtKB:A0A8I3PDQ1, ECO:0000250\|UniProtKB:O35177, ECO:0000269\|PubMed:17174122, ECO:0000269\|PubMed:17604723, ECO:0000269\|PubMed:24574519, ECO:0000269\|PubMed:9020138}.
Q14676	MDC1	S1173	ochoa	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q14676	MDC1	S1624	ochoa	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q14676	MDC1	S1786	ochoa	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q15154	PCM1	S372	psp	Pericentriolar material 1 protein (PCM-1) (hPCM-1)	Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites (PubMed:34782749). {ECO:0000269\|PubMed:12403812, ECO:0000269\|PubMed:15659651, ECO:0000269\|PubMed:16943179, ECO:0000269\|PubMed:20551181, ECO:0000269\|PubMed:24121310, ECO:0000269\|PubMed:27979967, ECO:0000269\|PubMed:34782749}.
Q15233	NONO	T424	ochoa	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)	DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250\|UniProtKB:Q99K48, ECO:0000269\|PubMed:10858305, ECO:0000269\|PubMed:11525732, ECO:0000269\|PubMed:11897684, ECO:0000269\|PubMed:12403470, ECO:0000269\|PubMed:15590677, ECO:0000269\|PubMed:22416126, ECO:0000269\|PubMed:26571461, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:30270045}.
Q15678	PTPN14	S538	ochoa	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269\|PubMed:10934049, ECO:0000269\|PubMed:12808048, ECO:0000269\|PubMed:17893246, ECO:0000269\|PubMed:20826270, ECO:0000269\|PubMed:22233626, ECO:0000269\|PubMed:22525271, ECO:0000269\|PubMed:22948661}.
Q15678	PTPN14	S758	ochoa	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269\|PubMed:10934049, ECO:0000269\|PubMed:12808048, ECO:0000269\|PubMed:17893246, ECO:0000269\|PubMed:20826270, ECO:0000269\|PubMed:22233626, ECO:0000269\|PubMed:22525271, ECO:0000269\|PubMed:22948661}.
Q15697	ZNF174	S188	ochoa	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)	Transcriptional repressor. {ECO:0000269\|PubMed:7673192}.
Q15772	SPEG	S334	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15772	SPEG	S540	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15911	ZFHX3	S3418	ochoa	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250\|UniProtKB:Q61329, ECO:0000269\|PubMed:11312261, ECO:0000269\|PubMed:17330845, ECO:0000269\|PubMed:20599712, ECO:0000269\|PubMed:20720010, ECO:0000269\|PubMed:25105025}.
Q15942	ZYX	S281	ochoa	Zyxin (Zyxin-2)	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16799	RTN1	S164	ochoa	Reticulon-1 (Neuroendocrine-specific protein)	Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269\|PubMed:15286784}.
Q2M3G4	SHROOM1	S186	ochoa	Protein Shroom1 (Apical protein 2)	May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}.
Q3YEC7	RABL6	S471	ochoa	Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1)	May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. {ECO:0000269\|PubMed:16582619}.
Q4KMQ1	TPRN	S278	ochoa	Taperin	Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250\|UniProtKB:A2AI08, ECO:0000269\|PubMed:23213405}.
Q4VCS5	AMOT	S859	ochoa	Angiomotin	Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269\|PubMed:11257124, ECO:0000269\|PubMed:16678097, ECO:0000269\|PubMed:21205866}.
Q504U0	C4orf46	S30	ochoa	Renal cancer differentiation gene 1 protein	None
Q58EX7	PLEKHG4	S677	ochoa	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)	Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Q5D1E8	ZC3H12A	S516	ochoa	Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)	Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250\|UniProtKB:Q5D1E7, ECO:0000269\|PubMed:16574901, ECO:0000269\|PubMed:18364357, ECO:0000269\|PubMed:19185603, ECO:0000269\|PubMed:19909337, ECO:0000269\|PubMed:22055188, ECO:0000269\|PubMed:22561375, ECO:0000269\|PubMed:24048733, ECO:0000269\|PubMed:25861989, ECO:0000269\|PubMed:26134560, ECO:0000269\|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269\|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269\|PubMed:24191027}.
Q5JPB2	ZNF831	S918	ochoa	Zinc finger protein 831	None
Q5JR12	PPM1J	S33	ochoa	Protein phosphatase 1J (EC 3.1.3.16) (Protein phosphatase 2C isoform zeta) (PP2C-zeta)	None
Q5JRA6	MIA3	S1884	ochoa	Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)	Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:19269366, PubMed:27138255). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). {ECO:0000269\|PubMed:19269366, ECO:0000269\|PubMed:27138255, ECO:0000269\|PubMed:28442536}.
Q5SNT2	TMEM201	S557	ochoa	Transmembrane protein 201 (Spindle-associated membrane protein 1)	Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250\|UniProtKB:A2A8U2, ECO:0000269\|PubMed:35311970, ECO:0000305\|PubMed:27541860}.; FUNCTION: [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090). {ECO:0000269\|PubMed:19494128, ECO:0000269\|PubMed:21610090}.
Q5SQI0	ATAT1	S276	ochoa	Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog)	Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255\|HAMAP-Rule:MF_03130, ECO:0000269\|PubMed:20829795, ECO:0000269\|PubMed:21068373, ECO:0000269\|PubMed:24097348, ECO:0000269\|PubMed:24906155}.
Q5T1M5	FKBP15	S965	ochoa	FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)	May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269\|PubMed:19121306}.
Q5VST9	OBSCN	S6831	ochoa	Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)	Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250\|UniProtKB:A2AAJ9, ECO:0000269\|PubMed:11448995, ECO:0000269\|PubMed:16205939, ECO:0000269\|PubMed:28826662}.
Q5VT52	RPRD2	S628	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VT52	RPRD2	S976	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VUA4	ZNF318	S709	ochoa	Zinc finger protein 318 (Endocrine regulatory protein)	[Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250\|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250\|UniProtKB:Q99PP2}.
Q66K74	MAP1S	S770	ochoa	Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain]	Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269\|PubMed:15899810, ECO:0000269\|PubMed:17234756}.
Q68CZ2	TNS3	S877	ochoa	Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250\|UniProtKB:Q5SSZ5, ECO:0000269\|PubMed:17643115, ECO:0000269\|PubMed:26166433, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:31905841, ECO:0000269\|PubMed:35687021, ECO:0000305}.
Q68DK2	ZFYVE26	S1782	ochoa	Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)	Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269\|PubMed:20208530}.
Q6GQQ9	OTUD7B	S460	ochoa	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250\|UniProtKB:B2RUR8, ECO:0000269\|PubMed:11463333, ECO:0000269\|PubMed:12682062, ECO:0000269\|PubMed:18178551, ECO:0000269\|PubMed:20622874, ECO:0000269\|PubMed:22179831, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:26903241, ECO:0000269\|PubMed:27732584, ECO:0000269\|PubMed:28489822}.
Q6ICG6	KIAA0930	S304	ochoa	Uncharacterized protein KIAA0930	None
Q6P1L5	FAM117B	S155	ochoa	Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein)	None
Q6P3S6	FBXO42	S376	ochoa	F-box only protein 42 (Just one F-box and Kelch domain-containing protein)	Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269\|PubMed:19509332}.
Q6PJG2	MIDEAS	S346	ochoa	Mitotic deacetylase-associated SANT domain protein (ELM2 and SANT domain-containing protein 1)	None
Q6VMQ6	ATF7IP	S849	ochoa	Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:14536086, ECO:0000269\|PubMed:19106100, ECO:0000269\|PubMed:27732843}.
Q6VMQ6	ATF7IP	S854	ochoa	Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269\|PubMed:12665582, ECO:0000269\|PubMed:14536086, ECO:0000269\|PubMed:19106100, ECO:0000269\|PubMed:27732843}.
Q6VN20	RANBP10	S376	ochoa	Ran-binding protein 10 (RanBP10)	May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). {ECO:0000250\|UniProtKB:Q6VN19, ECO:0000269\|PubMed:18222118, ECO:0000269\|PubMed:29911972, ECO:0000305}.
Q6ZRV2	FAM83H	S1009	ochoa	Protein FAM83H	May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269\|PubMed:18252228, ECO:0000269\|PubMed:23902688}.
Q6ZUM4	ARHGAP27	S455	ochoa	Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)	Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q71RC2	LARP4	S594	ochoa	La-related protein 4 (La ribonucleoprotein domain family member 4)	RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269\|PubMed:21098120, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:27615744}.
Q765P7	MTSS2	S612	ochoa	Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein)	Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269\|PubMed:14752106}.
Q76N32	CEP68	S368	ochoa	Centrosomal protein of 68 kDa (Cep68)	Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269\|PubMed:18042621, ECO:0000269\|PubMed:24554434, ECO:0000269\|PubMed:25503564, ECO:0000269\|PubMed:30404835}.
Q7Z2K8	GPRIN1	S862	ochoa	G protein-regulated inducer of neurite outgrowth 1 (GRIN1)	May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z2Z1	TICRR	S1141	ochoa	Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)	Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269\|PubMed:20116089}.
Q7Z3B3	KANSL1	S977	ochoa	KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)	Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:22547026, ECO:0000269\|PubMed:26243146, ECO:0000269\|PubMed:27768893, ECO:0000269\|PubMed:33657400}.
Q7Z434	MAVS	S233	ochoa\|psp	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269\|PubMed:16125763, ECO:0000269\|PubMed:16127453, ECO:0000269\|PubMed:16153868, ECO:0000269\|PubMed:16177806, ECO:0000269\|PubMed:19631370, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20451243, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:23087404, ECO:0000269\|PubMed:23582325, ECO:0000269\|PubMed:25636800, ECO:0000269\|PubMed:27736772, ECO:0000269\|PubMed:27992402, ECO:0000269\|PubMed:33110251, ECO:0000269\|PubMed:33139700, ECO:0000269\|PubMed:37582970}.
Q7Z434	MAVS	S402	ochoa	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269\|PubMed:16125763, ECO:0000269\|PubMed:16127453, ECO:0000269\|PubMed:16153868, ECO:0000269\|PubMed:16177806, ECO:0000269\|PubMed:19631370, ECO:0000269\|PubMed:20127681, ECO:0000269\|PubMed:20451243, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:21170385, ECO:0000269\|PubMed:23087404, ECO:0000269\|PubMed:23582325, ECO:0000269\|PubMed:25636800, ECO:0000269\|PubMed:27736772, ECO:0000269\|PubMed:27992402, ECO:0000269\|PubMed:33110251, ECO:0000269\|PubMed:33139700, ECO:0000269\|PubMed:37582970}.
Q7Z5J4	RAI1	S1122	ochoa	Retinoic acid-induced protein 1	Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269\|PubMed:22578325}.
Q7Z5L9	IRF2BP2	S406	ochoa	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269\|PubMed:12799427, ECO:0000269\|PubMed:20702774, ECO:0000269\|PubMed:21576369, ECO:0000269\|PubMed:27016798}.
Q86U90	YRDC	S53	ochoa	Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)	Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:29760464, PubMed:31481669, PubMed:34545459). Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate (PubMed:29760464). Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (PubMed:29760464). May regulate the activity of some transporters (By similarity). {ECO:0000250\|UniProtKB:Q3U5F4, ECO:0000269\|PubMed:29760464, ECO:0000269\|PubMed:31481669, ECO:0000269\|PubMed:34545459}.
Q86UX6	STK32C	S29	ochoa	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3)	None
Q86YD1	PTOV1	S36	ochoa\|psp	Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)	May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269\|PubMed:12598323, ECO:0000269\|PubMed:15713644, ECO:0000269\|PubMed:17641689}.
Q86YV5	PRAG1	S826	ochoa	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250\|UniProtKB:D3ZMK9, ECO:0000250\|UniProtKB:Q571I4}.
Q8IU68	TMC8	S694	ochoa	Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2)	Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:23429285, PubMed:30068544, PubMed:32917726). Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels (PubMed:25220380). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions (PubMed:23429285). {ECO:0000269\|PubMed:18158319, ECO:0000269\|PubMed:23429285, ECO:0000269\|PubMed:25220380, ECO:0000269\|PubMed:30068544, ECO:0000269\|PubMed:32917726}.
Q8IV63	VRK3	S115	psp	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IX01	SUGP2	S754	ochoa	SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)	May play a role in mRNA splicing. {ECO:0000305}.
Q8IX07	ZFPM1	S505	ochoa	Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)	Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.
Q8IY81	FTSJ3	S584	ochoa	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255\|HAMAP-Rule:MF_03163, ECO:0000269\|PubMed:22195017}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). {ECO:0000269\|PubMed:30626973}.
Q8IYB3	SRRM1	S234	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8IYB3	SRRM1	S777	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8IZ21	PHACTR4	S177	ochoa	Phosphatase and actin regulator 4	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZ21	PHACTR4	S248	ochoa	Phosphatase and actin regulator 4	Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
Q8IZP0	ABI1	S216	ochoa\|psp	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269\|PubMed:11003655, ECO:0000269\|PubMed:18328268}.
Q8N1G0	ZNF687	T148	ochoa	Zinc finger protein 687	May be involved in transcriptional regulation.
Q8N1G0	ZNF687	S241	ochoa	Zinc finger protein 687	May be involved in transcriptional regulation.
Q8N3F8	MICALL1	S493	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3F8	MICALL1	S589	ochoa	MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)	Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:Q8BGT6, ECO:0000269\|PubMed:19864458, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:21795389, ECO:0000269\|PubMed:23596323, ECO:0000269\|PubMed:31615969, ECO:0000269\|PubMed:34100897}.
Q8N3J3	HROB	T369	ochoa	Homologous recombination OB-fold protein	DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269\|PubMed:31467087}.
Q8N3L3	TXLNB	S554	ochoa	Beta-taxilin (Muscle-derived protein 77) (hMDP77)	Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}.
Q8N3V7	SYNPO	Y868	ochoa	Synaptopodin	Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N4C8	MINK1	S601	ochoa	Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250\|UniProtKB:F1LP90, ECO:0000250\|UniProtKB:Q9JM52, ECO:0000269\|PubMed:10708748, ECO:0000269\|PubMed:16337592, ECO:0000269\|PubMed:18930710, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N556	AFAP1	S679	ochoa	Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)	Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269\|PubMed:15485829}.
Q8NC96	NECAP1	S201	ochoa	Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)	Involved in endocytosis. {ECO:0000250}.
Q8TAP9	MPLKIP	S66	ochoa	M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein)	May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269\|PubMed:17310276}.
Q8TBN0	RAB3IL1	S179	ochoa	Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)	Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269\|PubMed:20937701}.
Q8TCT7	SPPL2B	S543	ochoa	Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)	Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269\|PubMed:16829951, ECO:0000269\|PubMed:16829952, ECO:0000269\|PubMed:17965014, ECO:0000269\|PubMed:19114711, ECO:0000269\|PubMed:22194595, ECO:0000269\|PubMed:23132852}.
Q8TD19	NEK9	S838	ochoa	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)	Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269\|PubMed:11864968, ECO:0000269\|PubMed:12101123, ECO:0000269\|PubMed:12840024, ECO:0000269\|PubMed:14660563, ECO:0000269\|PubMed:19941817, ECO:0000269\|PubMed:26522158}.
Q8TF72	SHROOM3	S755	ochoa	Protein Shroom3 (Shroom-related protein) (hShrmL)	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250\|UniProtKB:Q27IV2, ECO:0000250\|UniProtKB:Q9QXN0}.
Q8TF72	SHROOM3	S1492	ochoa	Protein Shroom3 (Shroom-related protein) (hShrmL)	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250\|UniProtKB:Q27IV2, ECO:0000250\|UniProtKB:Q9QXN0}.
Q8TF74	WIPF2	S272	ochoa	WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)	Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269\|PubMed:11829459, ECO:0000269\|PubMed:12213210}.
Q8WUA4	GTF3C2	S136	ochoa	General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)	Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
Q8WUA7	TBC1D22A	S143	ochoa	TBC1 domain family member 22A	May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}.
Q8WUF5	PPP1R13L	S134	ochoa	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)	Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269\|PubMed:10336463, ECO:0000269\|PubMed:12134007, ECO:0000269\|PubMed:12524540, ECO:0000269\|PubMed:15489900, ECO:0000269\|PubMed:28069640}.
Q8WUF5	PPP1R13L	S597	ochoa	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)	Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269\|PubMed:10336463, ECO:0000269\|PubMed:12134007, ECO:0000269\|PubMed:12524540, ECO:0000269\|PubMed:15489900, ECO:0000269\|PubMed:28069640}.
Q8WX93	PALLD	S708	ochoa	Palladin (SIH002) (Sarcoma antigen NY-SAR-77)	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269\|PubMed:11598191, ECO:0000269\|PubMed:15147863, ECO:0000269\|PubMed:17537434}.
Q8WX93	PALLD	S719	ochoa	Palladin (SIH002) (Sarcoma antigen NY-SAR-77)	Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269\|PubMed:11598191, ECO:0000269\|PubMed:15147863, ECO:0000269\|PubMed:17537434}.
Q8WXD9	CASKIN1	S953	ochoa	Caskin-1 (CASK-interacting protein 1)	May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXE0	CASKIN2	S798	ochoa	Caskin-2 (CASK-interacting protein 2)	None
Q92538	GBF1	S325	ochoa	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)	Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:12047556, PubMed:12808027, PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250\|UniProtKB:Q9R1D7, ECO:0000269\|PubMed:12047556, ECO:0000269\|PubMed:12808027, ECO:0000269\|PubMed:15616190, ECO:0000269\|PubMed:16926190, ECO:0000269\|PubMed:17666033, ECO:0000269\|PubMed:17956946, ECO:0000269\|PubMed:18003980, ECO:0000269\|PubMed:18063581, ECO:0000269\|PubMed:19461073, ECO:0000269\|PubMed:22185782, ECO:0000269\|PubMed:22573891, ECO:0000269\|PubMed:23386609, ECO:0000269\|PubMed:23418352, ECO:0000269\|PubMed:24213530, ECO:0000269\|PubMed:25190516, ECO:0000305\|PubMed:19039328, ECO:0000305\|PubMed:22573891}.
Q92545	TMEM131	S1342	ochoa	Transmembrane protein 131 (Protein RW1)	Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269\|PubMed:32095531}.
Q92918	MAP4K1	S447	ochoa	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)	Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250\|UniProtKB:P70218, ECO:0000269\|PubMed:24362026, ECO:0000269\|PubMed:26437443, ECO:0000269\|PubMed:8824585}.
Q969H4	CNKSR1	S300	ochoa	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)	May function as an adapter protein or regulator of Ras signaling pathways.
Q969V6	MRTFA	S303	ochoa	Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)	Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250\|UniProtKB:Q8K4J6, ECO:0000269\|PubMed:26224645}.
Q96AP7	ESAM	S338	ochoa	Endothelial cell-selective adhesion molecule	Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250\|UniProtKB:Q925F2}.
Q96CP6	GRAMD1A	S45	ochoa	Protein Aster-A (GRAM domain-containing protein 1A)	Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250\|UniProtKB:Q8VEF1, ECO:0000269\|PubMed:31222192}.
Q96FF9	CDCA5	S35	ochoa	Sororin (Cell division cycle-associated protein 5) (p35)	Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269\|PubMed:15837422, ECO:0000269\|PubMed:17349791, ECO:0000269\|PubMed:21111234}.
Q96GY3	LIN37	S182	ochoa\|psp	Protein lin-37 homolog (Antolefinin)	None
Q96I24	FUBP3	S458	ochoa	Far upstream element-binding protein 3 (FUSE-binding protein 3)	May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
Q96J84	KIRREL1	S680	ochoa	Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)	Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:31472902}.
Q96J84	KIRREL1	S683	ochoa	Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)	Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:31472902}.
Q96JC9	EAF1	S165	ochoa	ELL-associated factor 1	Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269\|PubMed:11418481, ECO:0000269\|PubMed:16006523}.
Q96JM3	CHAMP1	S330	ochoa	Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828)	Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269\|PubMed:21063390}.
Q96M11	HYLS1	S75	ochoa	Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1)	Plays a role in ciliogenesis. {ECO:0000250\|UniProtKB:A0A1L8ER70, ECO:0000250\|UniProtKB:Q95X94}.
Q96MX3	ZNF48	S420	ochoa	Zinc finger protein 48 (Zinc finger protein 553)	May be involved in transcriptional regulation.
Q96QU8	XPO6	S219	ochoa	Exportin-6 (Exp6) (Ran-binding protein 20)	Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269\|PubMed:14592989}.
Q96ST3	SIN3A	S251	ochoa	Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)	Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250\|UniProtKB:Q60520, ECO:0000269\|PubMed:12150998}.
Q96T58	SPEN	S3466	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q99700	ATXN2	S744	ochoa	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269\|PubMed:18602463}.
Q99856	ARID3A	S88	ochoa	AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)	Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269\|PubMed:11812999, ECO:0000269\|PubMed:12692263}.
Q9BQG0	MYBBP1A	S1248	ochoa	Myb-binding protein 1A	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250\|UniProtKB:Q7TPV4, ECO:0000269\|PubMed:29065309}.
Q9BQI5	SGIP1	S486	ochoa	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)	May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250\|UniProtKB:Q8VD37}.
Q9BQQ3	GORASP1	T246	ochoa	Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65)	Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250\|UniProtKB:O35254, ECO:0000269\|PubMed:16489344, ECO:0000269\|PubMed:21884936, ECO:0000269\|PubMed:33301566}.
Q9BU23	LMF2	S678	ochoa	Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)	Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}.
Q9BZ72	PITPNM2	S894	ochoa	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269\|PubMed:10022914}.
Q9C0E8	LNPK	S202	ochoa	Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark)	Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250\|UniProtKB:Q7TQ95, ECO:0000269\|PubMed:24223779, ECO:0000269\|PubMed:25404289, ECO:0000269\|PubMed:25548161, ECO:0000269\|PubMed:27619977, ECO:0000269\|PubMed:30032983}.
Q9C0E8	LNPK	S217	ochoa	Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark)	Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology (PubMed:30032983). Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb development (By similarity). Is involved in central nervous system development (PubMed:30032983). {ECO:0000250\|UniProtKB:Q7TQ95, ECO:0000269\|PubMed:24223779, ECO:0000269\|PubMed:25404289, ECO:0000269\|PubMed:25548161, ECO:0000269\|PubMed:27619977, ECO:0000269\|PubMed:30032983}.
Q9C0K0	BCL11B	S683	ochoa	B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1)	Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q99PV8, ECO:0000269\|PubMed:16809611, ECO:0000269\|PubMed:27959755}.
Q9H1B7	IRF2BPL	S615	ochoa	Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)	Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250\|UniProtKB:Q5EIC4, ECO:0000269\|PubMed:29374064, ECO:0000305\|PubMed:17334524, ECO:0000305\|PubMed:29374064, ECO:0000305\|PubMed:30057031}.
Q9H201	EPN3	S358	ochoa	Epsin-3 (EPS-15-interacting protein 3)	None
Q9H211	CDT1	S93	ochoa\|psp	DNA replication factor Cdt1 (Double parked homolog) (DUP)	Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250\|UniProtKB:Q8R4E9, ECO:0000269\|PubMed:11125146, ECO:0000269\|PubMed:14672932, ECO:0000269\|PubMed:14993212, ECO:0000269\|PubMed:21856198, ECO:0000269\|PubMed:22581055, ECO:0000269\|PubMed:26842564}.
Q9H2E6	SEMA6A	S810	ochoa	Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)	Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250\|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269\|PubMed:32302524, ECO:0000269\|PubMed:32589945}.
Q9H3P2	NELFA	S330	ochoa	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)	Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269\|PubMed:10199401, ECO:0000269\|PubMed:12563561, ECO:0000269\|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269\|PubMed:23884411}.
Q9H3P7	ACBD3	S54	ochoa	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]	Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250\|UniProtKB:Q8BMP6, ECO:0000269\|PubMed:11590181, ECO:0000269\|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269\|PubMed:22124328, ECO:0000269\|PubMed:22258260, ECO:0000269\|PubMed:27989622}.
Q9H3S7	PTPN23	S733	ochoa	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)	Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269\|PubMed:18434552, ECO:0000269\|PubMed:20393563, ECO:0000269\|PubMed:21757351}.
Q9H4G0	EPB41L1	S44	ochoa	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H6F5	CCDC86	S80	ochoa	Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)	Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269\|PubMed:36695333}.
Q9H6F5	CCDC86	S196	ochoa	Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)	Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269\|PubMed:36695333}.
Q9H7D0	DOCK5	T1800	ochoa	Dedicator of cytokinesis protein 5	Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250\|UniProtKB:B2RY04, ECO:0000269\|PubMed:19004829}.
Q9H7N4	SCAF1	S448	ochoa	Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)	May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9	PLEKHG2	S51	ochoa	Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)	May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250\|UniProtKB:Q6KAU7, ECO:0000269\|PubMed:18045877, ECO:0000269\|PubMed:26573021}.
Q9HB58	SP110	S157	ochoa	Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)	Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Q9HC56	PCDH9	S943	ochoa	Protocadherin-9	Potential calcium-dependent cell-adhesion protein.
Q9NP61	ARFGAP3	S154	ochoa	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)	GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269\|PubMed:11172815}.
Q9NQG6	MIEF1	S70	ochoa	Mitochondrial dynamics protein MIEF1 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein)	Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269\|PubMed:21508961, ECO:0000269\|PubMed:21701560, ECO:0000269\|PubMed:23283981, ECO:0000269\|PubMed:23530241, ECO:0000269\|PubMed:23921378, ECO:0000269\|PubMed:24515348, ECO:0000269\|PubMed:29083303, ECO:0000269\|PubMed:33632269}.
Q9NUE0	ZDHHC18	S53	ochoa	Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18)	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942). {ECO:0000269\|PubMed:23034182, ECO:0000269\|PubMed:27481942, ECO:0000269\|PubMed:35438208}.
Q9NV88	INTS9	S572	ochoa	Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74)	Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:22252320, PubMed:26308897, PubMed:30737432). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269\|PubMed:16239144, ECO:0000269\|PubMed:22252320, ECO:0000269\|PubMed:23904267, ECO:0000269\|PubMed:25201415, ECO:0000269\|PubMed:26308897, ECO:0000269\|PubMed:30737432, ECO:0000269\|PubMed:33243860, ECO:0000269\|PubMed:33548203, ECO:0000269\|PubMed:38570683}.
Q9NZM4	BICRA	S1534	ochoa	BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein)	Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454). {ECO:0000269\|PubMed:21555454, ECO:0000269\|PubMed:29374058}.
Q9P0K7	RAI14	S263	ochoa	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250\|UniProtKB:Q5U312}.
Q9P1Y6	PHRF1	S950	ochoa	PHD and RING finger domain-containing protein 1	None
Q9P206	NHSL3	S862	ochoa	NHS-like protein 3	Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269\|PubMed:32854746}.
Q9P275	USP36	S640	ochoa	Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)	Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269\|PubMed:19208757, ECO:0000269\|PubMed:21268071, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:22902402, ECO:0000269\|PubMed:25775507, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:29273634, ECO:0000269\|PubMed:29274341, ECO:0000269\|PubMed:35989368, ECO:0000269\|PubMed:36912080}.
Q9UBW5	BIN2	S430	ochoa	Bridging integrator 2 (Breast cancer-associated protein 1)	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269\|PubMed:23285027}.
Q9UBW5	BIN2	S458	ochoa	Bridging integrator 2 (Breast cancer-associated protein 1)	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269\|PubMed:23285027}.
Q9UBY0	SLC9A2	S760	ochoa	Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)	Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250\|UniProtKB:Q3ZAS0, ECO:0000269\|PubMed:10444453}.
Q9UDY2	TJP2	S1006	ochoa	Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)	Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250\|UniProtKB:Q9Z0U1}.
Q9UER7	DAXX	S682	ochoa	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:15364927, ECO:0000269\|PubMed:16845383, ECO:0000269\|PubMed:17081986, ECO:0000269\|PubMed:17942542, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:23222847, ECO:0000269\|PubMed:24200965, ECO:0000269\|PubMed:24530302}.
Q9UHB7	AFF4	S314	ochoa	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:23251033}.
Q9UHB7	AFF4	Y1069	ochoa	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:23251033}.
Q9UHV7	MED13	S2029	ochoa	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:16595664}.
Q9UIF9	BAZ2A	S28	ochoa	Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)	Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250\|UniProtKB:Q91YE5, ECO:0000269\|PubMed:28801535}.
Q9UJF2	RASAL2	S899	ochoa	Ras GTPase-activating protein nGAP (RAS protein activator-like 2)	Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UJM3	ERRFI1	S337	ochoa	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)	Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UKE5	TNIK	S660	ochoa	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269\|PubMed:10521462, ECO:0000269\|PubMed:15342639, ECO:0000269\|PubMed:19061864, ECO:0000269\|PubMed:19816403, ECO:0000269\|PubMed:20159449, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.
Q9UKV3	ACIN1	S400	ochoa	Apoptotic chromatin condensation inducer in the nucleus (Acinus)	Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269\|PubMed:10490026, ECO:0000269\|PubMed:12665594, ECO:0000269\|PubMed:18559500, ECO:0000269\|PubMed:22203037, ECO:0000269\|PubMed:22388736}.
Q9ULD5	ZNF777	S157	ochoa	Zinc finger protein 777	May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269\|PubMed:25560148, ECO:0000269\|PubMed:31856708}.
Q9ULV3	CIZ1	S578	ochoa	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	May regulate the subcellular localization of CIP/WAF1.
Q9UMN6	KMT2B	S1917	ochoa	Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250\|UniProtKB:O08550, ECO:0000269\|PubMed:17707229, ECO:0000269\|PubMed:24081332, ECO:0000269\|PubMed:25561738}.
Q9UN79	SOX13	S268	ochoa	Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)	Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250\|UniProtKB:Q04891, ECO:0000269\|PubMed:10871192, ECO:0000269\|PubMed:20028982}.
Q9UQR0	SCML2	S522	ochoa	Sex comb on midleg-like protein 2	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}.
Q9Y2L6	FRMD4B	S677	ochoa	FERM domain-containing protein 4B (GRP1-binding protein GRSP1)	Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250\|UniProtKB:Q920B0}.
Q9Y4F5	CEP170B	S986	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y520	PRRC2C	S779	ochoa	Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	Required for efficient formation of stress granules. {ECO:0000269\|PubMed:29395067}.
Q9Y570	PPME1	S27	ochoa	Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)	Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269\|PubMed:10318862}.
Q9Y5K6	CD2AP	S405	ochoa	CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250\|UniProtKB:F1LRS8, ECO:0000250\|UniProtKB:Q9JLQ0, ECO:0000269\|PubMed:10339567, ECO:0000269\|PubMed:15800069, ECO:0000269\|PubMed:22891260}.
Q9Y6D6	ARFGEF1	S1566	ochoa	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)	Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269\|PubMed:12571360, ECO:0000269\|PubMed:15644318, ECO:0000269\|PubMed:17227842, ECO:0000269\|PubMed:20360857, ECO:0000269\|PubMed:22084092}.
Q9Y6G9	DYNC1LI1	S412	ochoa	Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269\|PubMed:19229290, ECO:0000269\|PubMed:20026645}.
Q9Y6G9	DYNC1LI1	S419	ochoa	Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269\|PubMed:19229290, ECO:0000269\|PubMed:20026645}.
Q9Y6M5	SLC30A1	S173	ochoa	Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)	Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250\|UniProtKB:Q62720, ECO:0000269\|PubMed:18158319, ECO:0000269\|PubMed:31471319, ECO:0000269\|PubMed:32441444}.
Q14157	UBAP2L	S855	Sugiyama	Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L)	Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250\|UniProtKB:Q80X50, ECO:0000269\|PubMed:29395067, ECO:0000269\|PubMed:35633597}.
O95071	UBR5	S1878	Sugiyama	E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)	E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250\|UniProtKB:Q80TP3, ECO:0000269\|PubMed:11714696, ECO:0000269\|PubMed:21118991, ECO:0000269\|PubMed:21127351, ECO:0000269\|PubMed:21726808, ECO:0000269\|PubMed:22884692, ECO:0000269\|PubMed:28689657, ECO:0000269\|PubMed:29033132, ECO:0000269\|PubMed:29378950, ECO:0000269\|PubMed:33208877, ECO:0000269\|PubMed:35217622, ECO:0000269\|PubMed:37409633, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:37478862}.

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reactome_id	name	p	-log10_p
R-HSA-2028269	Signaling by Hippo	0.000005	5.320
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.000687	3.163
R-HSA-212165	Epigenetic regulation of gene expression	0.000965	3.016
R-HSA-75153	Apoptotic execution phase	0.000634	3.198
R-HSA-8878171	Transcriptional regulation by RUNX1	0.000955	3.020
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	0.001033	2.986
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.000855	3.068
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.001327	2.877
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.001392	2.856
R-HSA-186712	Regulation of beta-cell development	0.001890	2.724
R-HSA-3214841	PKMTs methylate histone lysines	0.002361	2.627
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.004751	2.323
R-HSA-210745	Regulation of gene expression in beta cells	0.004647	2.333
R-HSA-9008059	Interleukin-37 signaling	0.005126	2.290
R-HSA-112382	Formation of RNA Pol II elongation complex	0.006011	2.221
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.006431	2.192
R-HSA-74160	Gene expression (Transcription)	0.006285	2.202
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.007977	2.098
R-HSA-193648	NRAGE signals death through JNK	0.007815	2.107
R-HSA-9758919	Epithelial-Mesenchymal Transition (EMT) during gastrulation	0.010292	1.988
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	0.010292	1.988
R-HSA-4839726	Chromatin organization	0.014371	1.843
R-HSA-73857	RNA Polymerase II Transcription	0.015016	1.823
R-HSA-112412	SOS-mediated signalling	0.015689	1.804
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.017037	1.769
R-HSA-73887	Death Receptor Signaling	0.017588	1.755
R-HSA-9006821	Alternative Lengthening of Telomeres (ALT)	0.037055	1.431
R-HSA-9673013	Diseases of Telomere Maintenance	0.037055	1.431
R-HSA-9670621	Defective Inhibition of DNA Recombination at Telomere	0.037055	1.431
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	0.037055	1.431
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	0.037055	1.431
R-HSA-5339700	Signaling by TCF7L2 mutants	0.055066	1.259
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.090088	1.045
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	0.090088	1.045
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	0.090088	1.045
R-HSA-201688	WNT mediated activation of DVL	0.022043	1.657
R-HSA-74713	IRS activation	0.123815	0.907
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	0.123815	0.907
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.156296	0.806
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	0.156296	0.806
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.055541	1.255
R-HSA-8951430	RUNX3 regulates WNT signaling	0.172084	0.764
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.172084	0.764
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.065598	1.183
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.187577	0.727
R-HSA-8875656	MET receptor recycling	0.187577	0.727
R-HSA-167287	HIV elongation arrest and recovery	0.027297	1.564
R-HSA-167290	Pausing and recovery of HIV elongation	0.027297	1.564
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.076208	1.118
R-HSA-170984	ARMS-mediated activation	0.202781	0.693
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.081703	1.088
R-HSA-8875555	MET activates RAP1 and RAC1	0.217702	0.662
R-HSA-210990	PECAM1 interactions	0.232344	0.634
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.232344	0.634
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	0.246713	0.608
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.060516	1.218
R-HSA-179812	GRB2 events in EGFR signaling	0.260814	0.584
R-HSA-3000484	Scavenging by Class F Receptors	0.260814	0.584
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.129399	0.888
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.129399	0.888
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.135743	0.867
R-HSA-113418	Formation of the Early Elongation Complex	0.135743	0.867
R-HSA-9861559	PDH complex synthesizes acetyl-CoA from PYR	0.274652	0.561
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	0.274652	0.561
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.175072	0.757
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.188559	0.725
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.327469	0.485
R-HSA-3371511	HSF1 activation	0.195355	0.709
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.130287	0.885
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.092503	1.034
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.222809	0.652
R-HSA-3371568	Attenuation phase	0.222809	0.652
R-HSA-9670095	Inhibition of DNA recombination at telomere	0.222809	0.652
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.151940	0.818
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.151940	0.818
R-HSA-8854518	AURKA Activation by TPX2	0.165443	0.781
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	0.376451	0.424
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	0.179285	0.746
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.198205	0.703
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.198205	0.703
R-HSA-72165	mRNA Splicing - Minor Pathway	0.271403	0.566
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	0.399592	0.398
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.399592	0.398
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	0.399592	0.398
R-HSA-380287	Centrosome maturation	0.207840	0.682
R-HSA-6803529	FGFR2 alternative splicing	0.410840	0.386
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.410840	0.386
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.421877	0.375
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.421877	0.375
R-HSA-3371571	HSF1-dependent transactivation	0.306107	0.514
R-HSA-72187	mRNA 3'-end processing	0.313018	0.504
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.319913	0.495
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.340492	0.468
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.277612	0.557
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	0.367617	0.435
R-HSA-167172	Transcription of the HIV genome	0.174636	0.758
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.207078	0.684
R-HSA-72172	mRNA Splicing	0.416073	0.381
R-HSA-167169	HIV Transcription Elongation	0.222809	0.652
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.148630	0.828
R-HSA-8875878	MET promotes cell motility	0.054558	1.263
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.035468	1.450
R-HSA-72163	mRNA Splicing - Major Pathway	0.375313	0.426
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.119453	0.923
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.222809	0.652
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	0.183968	0.735
R-HSA-373753	Nephrin family interactions	0.081703	1.088
R-HSA-140342	Apoptosis induced DNA fragmentation	0.217702	0.662
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.274652	0.561
R-HSA-418885	DCC mediated attractive signaling	0.301558	0.521
R-HSA-6807878	COPI-mediated anterograde transport	0.145906	0.836
R-HSA-9609690	HCMV Early Events	0.382737	0.417
R-HSA-198203	PI3K/AKT activation	0.217702	0.662
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.314635	0.502
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.215912	0.666
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.410840	0.386
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	0.400891	0.397
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.020610	1.686
R-HSA-9842860	Regulation of endogenous retroelements	0.167102	0.777
R-HSA-191650	Regulation of gap junction activity	0.107110	0.970
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	0.060497	1.218
R-HSA-9931530	Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	0.260814	0.584
R-HSA-9796292	Formation of axial mesoderm	0.274652	0.561
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.328753	0.483
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.046607	1.332
R-HSA-74158	RNA Polymerase III Transcription	0.195355	0.709
R-HSA-74749	Signal attenuation	0.025555	1.593
R-HSA-4641265	Repression of WNT target genes	0.260814	0.584
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.188683	0.724
R-HSA-4608870	Asymmetric localization of PCP proteins	0.264447	0.578
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.271403	0.566
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.271403	0.566
R-HSA-9649948	Signaling downstream of RAS mutants	0.271403	0.566
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.319913	0.495
R-HSA-8851805	MET activates RAS signaling	0.037317	1.428
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.195355	0.709
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.123815	0.907
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	0.314635	0.502
R-HSA-9664420	Killing mechanisms	0.314635	0.502
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.202182	0.694
R-HSA-5674135	MAP2K and MAPK activation	0.236651	0.626
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.360874	0.443
R-HSA-162599	Late Phase of HIV Life Cycle	0.357394	0.447
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.050737	1.295
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	0.288231	0.540
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.098217	1.008
R-HSA-8856828	Clathrin-mediated endocytosis	0.190581	0.720
R-HSA-74751	Insulin receptor signalling cascade	0.394300	0.404
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.400076	0.398
R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.037317	1.428
R-HSA-9656223	Signaling by RAF1 mutants	0.236651	0.626
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.359469	0.444
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P...	0.202781	0.693
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.288231	0.540
R-HSA-6802949	Signaling by RAS mutants	0.271403	0.566
R-HSA-8856688	Golgi-to-ER retrograde transport	0.306517	0.514
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.327469	0.485
R-HSA-5696398	Nucleotide Excision Repair	0.181806	0.740
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.328753	0.483
R-HSA-68877	Mitotic Prometaphase	0.214179	0.669
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.072742	1.138
R-HSA-8875513	MET interacts with TNS proteins	0.090088	1.045
R-HSA-9022538	Loss of MECP2 binding ability to 5mC-DNA	0.090088	1.045
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	0.107110	0.970
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	0.055541	1.255
R-HSA-9932451	SWI/SNF chromatin remodelers	0.021552	1.667
R-HSA-9932444	ATP-dependent chromatin remodelers	0.021552	1.667
R-HSA-428543	Inactivation of CDC42 and RAC1	0.202781	0.693
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.217702	0.662
R-HSA-9034864	Activated NTRK3 signals through RAS	0.232344	0.634
R-HSA-209560	NF-kB is activated and signals survival	0.246713	0.608
R-HSA-428540	Activation of RAC1	0.246713	0.608
R-HSA-9026519	Activated NTRK2 signals through RAS	0.246713	0.608
R-HSA-202670	ERKs are inactivated	0.246713	0.608
R-HSA-180336	SHC1 events in EGFR signaling	0.301558	0.521
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.314635	0.502
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.327469	0.485
R-HSA-73856	RNA Polymerase II Transcription Termination	0.143144	0.844
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.352421	0.453
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.364550	0.438
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.388131	0.411
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.399592	0.398
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.399592	0.398
R-HSA-933542	TRAF6 mediated NF-kB activation	0.432709	0.364
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.432709	0.364
R-HSA-2428928	IRS-related events triggered by IGF1R	0.374333	0.427
R-HSA-168325	Viral Messenger RNA Synthesis	0.374333	0.427
R-HSA-5693606	DNA Double Strand Break Response	0.413972	0.383
R-HSA-2428924	IGF1R signaling cascade	0.394300	0.404
R-HSA-9646399	Aggrephagy	0.222809	0.652
R-HSA-193639	p75NTR signals via NF-kB	0.301558	0.521
R-HSA-2980766	Nuclear Envelope Breakdown	0.347310	0.459
R-HSA-9843745	Adipogenesis	0.302304	0.520
R-HSA-209543	p75NTR recruits signalling complexes	0.260814	0.584
R-HSA-432142	Platelet sensitization by LDL	0.352421	0.453
R-HSA-112399	IRS-mediated signalling	0.347310	0.459
R-HSA-201681	TCF dependent signaling in response to WNT	0.185319	0.732
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	0.181797	0.740
R-HSA-500753	Pyrimidine biosynthesis	0.364550	0.438
R-HSA-9609523	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	0.376451	0.424
R-HSA-427413	NoRC negatively regulates rRNA expression	0.188683	0.724
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.400891	0.397
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.348893	0.457
R-HSA-199977	ER to Golgi Anterograde Transport	0.203610	0.691
R-HSA-162587	HIV Life Cycle	0.420852	0.376
R-HSA-9842663	Signaling by LTK	0.037317	1.428
R-HSA-9764302	Regulation of CDH19 Expression and Function	0.140208	0.853
R-HSA-446353	Cell-extracellular matrix interactions	0.050737	1.295
R-HSA-9603381	Activated NTRK3 signals through PI3K	0.172084	0.764
R-HSA-2428933	SHC-related events triggered by IGF1R	0.260814	0.584
R-HSA-156711	Polo-like kinase mediated events	0.352421	0.453
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.410840	0.386
R-HSA-3214815	HDACs deacetylate histones	0.333652	0.477
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	0.399805	0.398
R-HSA-6806834	Signaling by MET	0.026833	1.571
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.052973	1.276
R-HSA-9664417	Leishmania phagocytosis	0.344644	0.463
R-HSA-9664422	FCGR3A-mediated phagocytosis	0.344644	0.463
R-HSA-9664407	Parasite infection	0.344644	0.463
R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	0.301558	0.521
R-HSA-195721	Signaling by WNT	0.394236	0.404
R-HSA-9729555	Sensory perception of sour taste	0.107110	0.970
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.140208	0.853
R-HSA-9675151	Disorders of Developmental Biology	0.060497	1.218
R-HSA-354192	Integrin signaling	0.038502	1.415
R-HSA-2179392	EGFR Transactivation by Gastrin	0.217702	0.662
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.217702	0.662
R-HSA-1483226	Synthesis of PI	0.232344	0.634
R-HSA-912526	Interleukin receptor SHC signaling	0.104798	0.980
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.388131	0.411
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.252325	0.598
R-HSA-169893	Prolonged ERK activation events	0.314635	0.502
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.193429	0.713
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.041135	1.386
R-HSA-9664873	Pexophagy	0.217702	0.662
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.432709	0.364
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.432709	0.364
R-HSA-8878159	Transcriptional regulation by RUNX3	0.055610	1.255
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.080101	1.096
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.135743	0.867
R-HSA-9028731	Activated NTRK2 signals through FRS2 and FRS3	0.260814	0.584
R-HSA-205043	NRIF signals cell death from the nucleus	0.288231	0.540
R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	0.301558	0.521
R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	0.301558	0.521
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.229723	0.639
R-HSA-912631	Regulation of signaling by CBL	0.364550	0.438
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.174636	0.758
R-HSA-5689603	UCH proteinases	0.212696	0.672
R-HSA-199991	Membrane Trafficking	0.284758	0.546
R-HSA-8943724	Regulation of PTEN gene transcription	0.041135	1.386
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.352421	0.453
R-HSA-948021	Transport to the Golgi and subsequent modification	0.404983	0.393
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.037196	1.430
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	0.188559	0.725
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.147520	0.831
R-HSA-9860931	Response of endothelial cells to shear stress	0.174400	0.758
R-HSA-5673001	RAF/MAP kinase cascade	0.366701	0.436
R-HSA-389542	NADPH regeneration	0.156296	0.806
R-HSA-425986	Sodium/Proton exchangers	0.187577	0.727
R-HSA-9022702	MECP2 regulates transcription of neuronal ligands	0.217702	0.662
R-HSA-9671555	Signaling by PDGFR in disease	0.093039	1.031
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	0.260814	0.584
R-HSA-877312	Regulation of IFNG signaling	0.260814	0.584
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.274652	0.561
R-HSA-186763	Downstream signal transduction	0.155164	0.809
R-HSA-9027284	Erythropoietin activates RAS	0.301558	0.521
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.301558	0.521
R-HSA-445355	Smooth Muscle Contraction	0.109849	0.959
R-HSA-187687	Signalling to ERKs	0.188559	0.725
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.215912	0.666
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	0.399592	0.398
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.232355	0.634
R-HSA-9663891	Selective autophagy	0.277612	0.557
R-HSA-194138	Signaling by VEGF	0.051475	1.288
R-HSA-5684996	MAPK1/MAPK3 signaling	0.388111	0.411
R-HSA-9022699	MECP2 regulates neuronal receptors and channels	0.023385	1.631
R-HSA-9659379	Sensory processing of sound	0.227408	0.643
R-HSA-69275	G2/M Transition	0.193811	0.713
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.037317	1.428
R-HSA-9758890	Transport of RCbl within the body	0.232344	0.634
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.340063	0.468
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.340063	0.468
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.364550	0.438
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.399592	0.398
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.410840	0.386
R-HSA-453274	Mitotic G2-G2/M phases	0.199554	0.700
R-HSA-8941326	RUNX2 regulates bone development	0.195355	0.709
R-HSA-375165	NCAM signaling for neurite out-growth	0.381019	0.419
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.051690	1.287
R-HSA-5689896	Ovarian tumor domain proteases	0.202182	0.694
R-HSA-9855142	Cellular responses to mechanical stimuli	0.216325	0.665
R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.093039	1.031
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	0.018751	1.727
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	0.140208	0.853
R-HSA-9005895	Pervasive developmental disorders	0.260814	0.584
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	0.260814	0.584
R-HSA-9697154	Disorders of Nervous System Development	0.260814	0.584
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.068707	1.163
R-HSA-167044	Signalling to RAS	0.388131	0.411
R-HSA-200425	Carnitine shuttle	0.421877	0.375
R-HSA-5617833	Cilium Assembly	0.205359	0.687
R-HSA-69278	Cell Cycle, Mitotic	0.318362	0.497
R-HSA-1500931	Cell-Cell communication	0.027554	1.560
R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m...	0.410840	0.386
R-HSA-193704	p75 NTR receptor-mediated signalling	0.019088	1.719
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.312974	0.504
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.388131	0.411
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.388131	0.411
R-HSA-1640170	Cell Cycle	0.304521	0.516
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.292250	0.534
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	0.432709	0.364
R-HSA-5683057	MAPK family signaling cascades	0.390488	0.408
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.297849	0.526
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.297849	0.526
R-HSA-9823730	Formation of definitive endoderm	0.376451	0.424
R-HSA-3247509	Chromatin modifying enzymes	0.054080	1.267
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.115495	0.937
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	0.093039	1.031
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.252325	0.598
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	0.123815	0.907
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	0.217702	0.662
R-HSA-69205	G1/S-Specific Transcription	0.048898	1.311
R-HSA-201556	Signaling by ALK	0.215912	0.666
R-HSA-210993	Tie2 Signaling	0.352421	0.453
R-HSA-198753	ERK/MAPK targets	0.388131	0.411
R-HSA-446728	Cell junction organization	0.114629	0.941
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.305140	0.516
R-HSA-162582	Signal Transduction	0.154865	0.810
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	0.148630	0.828
R-HSA-418990	Adherens junctions interactions	0.166623	0.778
R-HSA-5655291	Signaling by FGFR4 in disease	0.288231	0.540
R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	0.388131	0.411
R-HSA-1266738	Developmental Biology	0.333887	0.476
R-HSA-421270	Cell-cell junction organization	0.253848	0.595
R-HSA-186797	Signaling by PDGF	0.381019	0.419
R-HSA-1980143	Signaling by NOTCH1	0.212696	0.672
R-HSA-166520	Signaling by NTRKs	0.382875	0.417
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.285527	0.544
R-HSA-1433559	Regulation of KIT signaling	0.288231	0.540
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL...	0.314635	0.502
R-HSA-428643	Organic anion transport by SLC5/17/25 transporters	0.352421	0.453
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.340492	0.468
R-HSA-373755	Semaphorin interactions	0.387675	0.412
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	0.038502	1.415
R-HSA-177929	Signaling by EGFR	0.340492	0.468
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.055541	1.255
R-HSA-9831926	Nephron development	0.070838	1.150
R-HSA-9819196	Zygotic genome activation (ZGA)	0.388131	0.411
R-HSA-8986944	Transcriptional Regulation by MECP2	0.292904	0.533
R-HSA-9856651	MITF-M-dependent gene expression	0.042036	1.376
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	0.087315	1.059
R-HSA-416700	Other semaphorin interactions	0.301558	0.521
R-HSA-6787450	tRNA modification in the mitochondrion	0.327469	0.485
R-HSA-9833110	RSV-host interactions	0.178090	0.749
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.420852	0.376
R-HSA-5655253	Signaling by FGFR2 in disease	0.299184	0.524
R-HSA-109581	Apoptosis	0.128081	0.893
R-HSA-2586552	Signaling by Leptin	0.217702	0.662
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	0.069996	1.155
R-HSA-212436	Generic Transcription Pathway	0.097059	1.013
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.202781	0.693
R-HSA-9762292	Regulation of CDH11 function	0.217702	0.662
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.274652	0.561
R-HSA-391160	Signal regulatory protein family interactions	0.288231	0.540
R-HSA-5620916	VxPx cargo-targeting to cilium	0.376451	0.424
R-HSA-9833482	PKR-mediated signaling	0.232355	0.634
R-HSA-9758941	Gastrulation	0.387113	0.412
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.367617	0.435
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.367617	0.435
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.367617	0.435
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.367617	0.435
R-HSA-9730414	MITF-M-regulated melanocyte development	0.077003	1.113
R-HSA-1980145	Signaling by NOTCH2	0.181797	0.740
R-HSA-180292	GAB1 signalosome	0.352421	0.453
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.352421	0.453
R-HSA-75893	TNF signaling	0.340492	0.468
R-HSA-9634638	Estrogen-dependent nuclear events downstream of ESR-membrane signaling	0.421877	0.375
R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	0.432709	0.364
R-HSA-9679191	Potential therapeutics for SARS	0.391348	0.407
R-HSA-9012852	Signaling by NOTCH3	0.333652	0.477
R-HSA-5357801	Programmed Cell Death	0.253797	0.596
R-HSA-417957	P2Y receptors	0.288231	0.540
R-HSA-435354	Zinc transporters	0.288231	0.540
R-HSA-9669938	Signaling by KIT in disease	0.410840	0.386
R-HSA-8848021	Signaling by PTK6	0.387675	0.412
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.387675	0.412
R-HSA-9762293	Regulation of CDH11 gene transcription	0.202781	0.693
R-HSA-9759475	Regulation of CDH11 Expression and Function	0.142155	0.847
R-HSA-425410	Metal ion SLC transporters	0.285307	0.545
R-HSA-6807070	PTEN Regulation	0.340395	0.468
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.408241	0.389
R-HSA-416482	G alpha (12/13) signalling events	0.024641	1.608
R-HSA-418038	Nucleotide-like (purinergic) receptors	0.352421	0.453
R-HSA-2559583	Cellular Senescence	0.323477	0.490
R-HSA-8983432	Interleukin-15 signaling	0.260814	0.584
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	0.168389	0.774
R-HSA-196791	Vitamin D (calciferol) metabolism	0.352421	0.453
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.367617	0.435
R-HSA-451927	Interleukin-2 family signaling	0.222809	0.652
R-HSA-3700989	Transcriptional Regulation by TP53	0.211447	0.675
R-HSA-2559580	Oxidative Stress Induced Senescence	0.167102	0.777
R-HSA-5357905	Regulation of TNFR1 signaling	0.271403	0.566
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.347310	0.459
R-HSA-9830369	Kidney development	0.413972	0.383
R-HSA-982772	Growth hormone receptor signaling	0.421877	0.375
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.331904	0.479
R-HSA-446652	Interleukin-1 family signaling	0.220300	0.657
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.433323	0.363
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.439697	0.357
R-HSA-9620244	Long-term potentiation	0.443338	0.353
R-HSA-9839394	TGFBR3 expression	0.443338	0.353
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.443338	0.353
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.443338	0.353
R-HSA-3214842	HDMs demethylate histones	0.443338	0.353
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.443338	0.353
R-HSA-1266695	Interleukin-7 signaling	0.443338	0.353
R-HSA-5578749	Transcriptional regulation by small RNAs	0.446032	0.351
R-HSA-8874081	MET activates PTK2 signaling	0.453768	0.343
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.453768	0.343
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	0.453768	0.343
R-HSA-1643713	Signaling by EGFR in Cancer	0.453768	0.343
R-HSA-525793	Myogenesis	0.453768	0.343
R-HSA-9703465	Signaling by FLT3 fusion proteins	0.453768	0.343
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.453768	0.343
R-HSA-1226099	Signaling by FGFR in disease	0.458581	0.339
R-HSA-1236394	Signaling by ERBB4	0.458581	0.339
R-HSA-9013694	Signaling by NOTCH4	0.458581	0.339
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.464004	0.333
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.464004	0.333
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.464004	0.333
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	0.464004	0.333
R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.464004	0.333
R-HSA-5655332	Signaling by FGFR3 in disease	0.464004	0.333
R-HSA-68875	Mitotic Prophase	0.464350	0.333
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.464794	0.333
R-HSA-3371556	Cellular response to heat stress	0.469176	0.329
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.469176	0.329
R-HSA-9619483	Activation of AMPK downstream of NMDARs	0.474049	0.324
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.474049	0.324
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	0.474049	0.324
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.478769	0.320
R-HSA-4086400	PCP/CE pathway	0.483177	0.316
R-HSA-72086	mRNA Capping	0.483906	0.315
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.483906	0.315
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.483906	0.315
R-HSA-5654708	Downstream signaling of activated FGFR3	0.483906	0.315
R-HSA-9006335	Signaling by Erythropoietin	0.483906	0.315
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.483906	0.315
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.486780	0.313
R-HSA-68886	M Phase	0.492244	0.308
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.493005	0.307
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.493005	0.307
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.493005	0.307
R-HSA-69206	G1/S Transition	0.493005	0.307
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.493578	0.307
R-HSA-2424491	DAP12 signaling	0.493578	0.307
R-HSA-68962	Activation of the pre-replicative complex	0.493578	0.307
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.493578	0.307
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.493578	0.307
R-HSA-5654716	Downstream signaling of activated FGFR4	0.493578	0.307
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.494820	0.306
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	0.495214	0.305
R-HSA-5654738	Signaling by FGFR2	0.495214	0.305
R-HSA-5653656	Vesicle-mediated transport	0.499950	0.301
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.503070	0.298
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.503070	0.298
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	0.503070	0.298
R-HSA-5694530	Cargo concentration in the ER	0.503070	0.298
R-HSA-399719	Trafficking of AMPA receptors	0.503070	0.298
R-HSA-9833109	Evasion by RSV of host interferon responses	0.503070	0.298
R-HSA-1538133	G0 and Early G1	0.512385	0.290
R-HSA-9675126	Diseases of mitotic cell cycle	0.512385	0.290
R-HSA-9937080	Developmental Lineage of Multipotent Pancreatic Progenitor Cells	0.512385	0.290
R-HSA-4791275	Signaling by WNT in cancer	0.512385	0.290
R-HSA-9707564	Cytoprotection by HMOX1	0.512933	0.290
R-HSA-1855170	IPs transport between nucleus and cytosol	0.521526	0.283
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.521526	0.283
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.521526	0.283
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	0.521526	0.283
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	0.521526	0.283
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.521526	0.283
R-HSA-9022692	Regulation of MECP2 expression and activity	0.521526	0.283
R-HSA-6802957	Oncogenic MAPK signaling	0.524516	0.280
R-HSA-9909396	Circadian clock	0.529994	0.276
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.530238	0.276
R-HSA-141424	Amplification of signal from the kinetochores	0.530238	0.276
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.530238	0.276
R-HSA-390522	Striated Muscle Contraction	0.530496	0.275
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.530496	0.275
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.530496	0.275
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.530496	0.275
R-HSA-202733	Cell surface interactions at the vascular wall	0.534360	0.272
R-HSA-8939211	ESR-mediated signaling	0.534360	0.272
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	0.539298	0.268
R-HSA-5673000	RAF activation	0.539298	0.268
R-HSA-180746	Nuclear import of Rev protein	0.539298	0.268
R-HSA-5205647	Mitophagy	0.539298	0.268
R-HSA-438064	Post NMDA receptor activation events	0.541541	0.266
R-HSA-2559585	Oncogene Induced Senescence	0.547936	0.261
R-HSA-5654696	Downstream signaling of activated FGFR2	0.547936	0.261
R-HSA-5654687	Downstream signaling of activated FGFR1	0.547936	0.261
R-HSA-3858494	Beta-catenin independent WNT signaling	0.552334	0.258
R-HSA-9018519	Estrogen-dependent gene expression	0.552334	0.258
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	0.556412	0.255
R-HSA-8853659	RET signaling	0.556412	0.255
R-HSA-9682385	FLT3 signaling in disease	0.556412	0.255
R-HSA-6804757	Regulation of TP53 Degradation	0.556412	0.255
R-HSA-1839126	FGFR2 mutant receptor activation	0.556412	0.255
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.559196	0.252
R-HSA-449147	Signaling by Interleukins	0.563329	0.249
R-HSA-4641258	Degradation of DVL	0.564730	0.248
R-HSA-933541	TRAF6 mediated IRF7 activation	0.564730	0.248
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.564730	0.248
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.564730	0.248
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.572893	0.242
R-HSA-1632852	Macroautophagy	0.574037	0.241
R-HSA-74752	Signaling by Insulin receptor	0.574309	0.241
R-HSA-9609646	HCMV Infection	0.577988	0.238
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.580903	0.236
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.580903	0.236
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.580903	0.236
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.580903	0.236
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.580903	0.236
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.588763	0.230
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.588763	0.230
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	0.588763	0.230
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	0.588763	0.230
R-HSA-177243	Interactions of Rev with host cellular proteins	0.588763	0.230
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.588763	0.230
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.588763	0.230
R-HSA-1251985	Nuclear signaling by ERBB4	0.588763	0.230
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.593800	0.226
R-HSA-389948	Co-inhibition by PD-1	0.593800	0.226
R-HSA-5688426	Deubiquitination	0.594185	0.226
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.596476	0.224
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.596476	0.224
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.596476	0.224
R-HSA-8853884	Transcriptional Regulation by VENTX	0.596476	0.224
R-HSA-9607240	FLT3 Signaling	0.596476	0.224
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.599202	0.222
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.604045	0.219
R-HSA-167161	HIV Transcription Initiation	0.604045	0.219
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.604045	0.219
R-HSA-5610780	Degradation of GLI1 by the proteasome	0.604045	0.219
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.604045	0.219
R-HSA-5675221	Negative regulation of MAPK pathway	0.604045	0.219
R-HSA-5655302	Signaling by FGFR1 in disease	0.604045	0.219
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	0.604045	0.219
R-HSA-157579	Telomere Maintenance	0.605342	0.218
R-HSA-69242	S Phase	0.607371	0.217
R-HSA-190236	Signaling by FGFR	0.610345	0.214
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.611473	0.214
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.611473	0.214
R-HSA-73776	RNA Polymerase II Promoter Escape	0.618761	0.208
R-HSA-5654743	Signaling by FGFR4	0.618761	0.208
R-HSA-1433557	Signaling by SCF-KIT	0.618761	0.208
R-HSA-9734767	Developmental Cell Lineages	0.619372	0.208
R-HSA-69618	Mitotic Spindle Checkpoint	0.620206	0.207
R-HSA-70171	Glycolysis	0.620206	0.207
R-HSA-1852241	Organelle biogenesis and maintenance	0.621272	0.207
R-HSA-9009391	Extra-nuclear estrogen signaling	0.625064	0.204
R-HSA-2172127	DAP12 interactions	0.625914	0.203
R-HSA-373752	Netrin-1 signaling	0.625914	0.203
R-HSA-3928662	EPHB-mediated forward signaling	0.625914	0.203
R-HSA-3214858	RMTs methylate histone arginines	0.625914	0.203
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.625914	0.203
R-HSA-5683826	Surfactant metabolism	0.625914	0.203
R-HSA-5693532	DNA Double-Strand Break Repair	0.627308	0.203
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.629874	0.201
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.632932	0.199
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.632932	0.199
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.632932	0.199
R-HSA-5654741	Signaling by FGFR3	0.632932	0.199
R-HSA-69601	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	0.632932	0.199
R-HSA-69613	p53-Independent G1/S DNA Damage Checkpoint	0.632932	0.199
R-HSA-9711123	Cellular response to chemical stress	0.634638	0.197
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.635086	0.197
R-HSA-1989781	PPARA activates gene expression	0.635086	0.197
R-HSA-397014	Muscle contraction	0.638778	0.195
R-HSA-9612973	Autophagy	0.638933	0.195
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.639820	0.194
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.639820	0.194
R-HSA-9861718	Regulation of pyruvate metabolism	0.639820	0.194
R-HSA-9839373	Signaling by TGFBR3	0.639820	0.194
R-HSA-5619507	Activation of HOX genes during differentiation	0.644016	0.191
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.644016	0.191
R-HSA-437239	Recycling pathway of L1	0.646578	0.189
R-HSA-68882	Mitotic Anaphase	0.651950	0.186
R-HSA-76002	Platelet activation, signaling and aggregation	0.652458	0.185
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.653210	0.185
R-HSA-8963899	Plasma lipoprotein remodeling	0.653210	0.185
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.655192	0.184
R-HSA-211000	Gene Silencing by RNA	0.657729	0.182
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.657729	0.182
R-HSA-9700206	Signaling by ALK in cancer	0.657729	0.182
R-HSA-157858	Gap junction trafficking and regulation	0.659718	0.181
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.659718	0.181
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.662205	0.179
R-HSA-5658442	Regulation of RAS by GAPs	0.666105	0.176
R-HSA-109704	PI3K Cascade	0.666105	0.176
R-HSA-2467813	Separation of Sister Chromatids	0.668681	0.175
R-HSA-9864848	Complex IV assembly	0.672372	0.172
R-HSA-9658195	Leishmania infection	0.672541	0.172
R-HSA-9824443	Parasitic Infection Pathways	0.672541	0.172
R-HSA-68949	Orc1 removal from chromatin	0.678521	0.168
R-HSA-6794361	Neurexins and neuroligins	0.678521	0.168
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	0.678521	0.168
R-HSA-1483249	Inositol phosphate metabolism	0.679643	0.168
R-HSA-8956320	Nucleotide biosynthesis	0.684556	0.165
R-HSA-162906	HIV Infection	0.686502	0.163
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.693214	0.159
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.696288	0.157
R-HSA-5654736	Signaling by FGFR1	0.701990	0.154
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.701990	0.154
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.701990	0.154
R-HSA-8953897	Cellular responses to stimuli	0.703241	0.153
R-HSA-9007101	Rab regulation of trafficking	0.708387	0.150
R-HSA-70326	Glucose metabolism	0.708387	0.150
R-HSA-1257604	PIP3 activates AKT signaling	0.710368	0.149
R-HSA-5693538	Homology Directed Repair	0.712314	0.147
R-HSA-6782135	Dual incision in TC-NER	0.713076	0.147
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu...	0.713076	0.147
R-HSA-8878166	Transcriptional regulation by RUNX2	0.716196	0.145
R-HSA-191859	snRNP Assembly	0.718464	0.144
R-HSA-194441	Metabolism of non-coding RNA	0.718464	0.144
R-HSA-168255	Influenza Infection	0.722718	0.141
R-HSA-983189	Kinesins	0.723751	0.140
R-HSA-1227986	Signaling by ERBB2	0.723751	0.140
R-HSA-5362517	Signaling by Retinoic Acid	0.723751	0.140
R-HSA-73886	Chromosome Maintenance	0.723828	0.140
R-HSA-9759194	Nuclear events mediated by NFE2L2	0.723828	0.140
R-HSA-73894	DNA Repair	0.724088	0.140
R-HSA-450294	MAP kinase activation	0.728939	0.137
R-HSA-9006931	Signaling by Nuclear Receptors	0.730953	0.136
R-HSA-6784531	tRNA processing in the nucleus	0.734030	0.134
R-HSA-9707616	Heme signaling	0.734030	0.134
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.734030	0.134
R-HSA-69615	G1/S DNA Damage Checkpoints	0.739026	0.131
R-HSA-114608	Platelet degranulation	0.749190	0.125
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.749971	0.125
R-HSA-109582	Hemostasis	0.754933	0.122
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	0.762636	0.118
R-HSA-388841	Regulation of T cell activation by CD28 family	0.765740	0.116
R-HSA-69620	Cell Cycle Checkpoints	0.770581	0.113
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.771472	0.113
R-HSA-204005	COPII-mediated vesicle transport	0.771472	0.113
R-HSA-75105	Fatty acyl-CoA biosynthesis	0.771472	0.113
R-HSA-69202	Cyclin E associated events during G1/S transition	0.771472	0.113
R-HSA-448424	Interleukin-17 signaling	0.771472	0.113
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.772529	0.112
R-HSA-5632684	Hedgehog 'on' state	0.775767	0.110
R-HSA-975634	Retinoid metabolism and transport	0.775767	0.110
R-HSA-8978934	Metabolism of cofactors	0.775767	0.110
R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activ...	0.775767	0.110
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.779981	0.108
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.779981	0.108
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.779981	0.108
R-HSA-69052	Switching of origins to a post-replicative state	0.784116	0.106
R-HSA-4086398	Ca2+ pathway	0.784116	0.106
R-HSA-69473	G2/M DNA damage checkpoint	0.788174	0.103
R-HSA-1222556	ROS and RNS production in phagocytes	0.788174	0.103
R-HSA-376176	Signaling by ROBO receptors	0.790589	0.102
R-HSA-71403	Citric acid cycle (TCA cycle)	0.792156	0.101
R-HSA-1169408	ISG15 antiviral mechanism	0.792156	0.101
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.796063	0.099
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	0.799896	0.097
R-HSA-383280	Nuclear Receptor transcription pathway	0.803658	0.095
R-HSA-9955298	SLC-mediated transport of organic anions	0.803658	0.095
R-HSA-73864	RNA Polymerase I Transcription	0.803658	0.095
R-HSA-216083	Integrin cell surface interactions	0.803658	0.095
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.805385	0.094
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.810972	0.091
R-HSA-9006925	Intracellular signaling by second messengers	0.814464	0.089
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.814515	0.089
R-HSA-5693607	Processing of DNA double-strand break ends	0.814527	0.089
R-HSA-6806667	Metabolism of fat-soluble vitamins	0.814527	0.089
R-HSA-9824446	Viral Infection Pathways	0.822965	0.085
R-HSA-8953854	Metabolism of RNA	0.824432	0.084
R-HSA-6794362	Protein-protein interactions at synapses	0.828091	0.082
R-HSA-5687128	MAPK6/MAPK4 signaling	0.828091	0.082
R-HSA-1280215	Cytokine Signaling in Immune system	0.828563	0.082
R-HSA-9755511	KEAP1-NFE2L2 pathway	0.829064	0.081
R-HSA-2262752	Cellular responses to stress	0.831303	0.080
R-HSA-70268	Pyruvate metabolism	0.837610	0.077
R-HSA-156902	Peptide chain elongation	0.840665	0.075
R-HSA-9610379	HCMV Late Events	0.843380	0.074
R-HSA-446203	Asparagine N-linked glycosylation	0.843530	0.074
R-HSA-112310	Neurotransmitter release cycle	0.846605	0.072
R-HSA-73884	Base Excision Repair	0.846605	0.072
R-HSA-9705683	SARS-CoV-2-host interactions	0.847974	0.072
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	0.849491	0.071
R-HSA-5633007	Regulation of TP53 Activity	0.850124	0.071
R-HSA-9006936	Signaling by TGFB family members	0.850124	0.071
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.852323	0.069
R-HSA-156842	Eukaryotic Translation Elongation	0.855102	0.068
R-HSA-2682334	EPH-Ephrin signaling	0.855102	0.068
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	0.855102	0.068
R-HSA-72312	rRNA processing	0.855475	0.068
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge...	0.857829	0.067
R-HSA-68867	Assembly of the pre-replicative complex	0.857829	0.067
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.860505	0.065
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	0.863131	0.064
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.863131	0.064
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	0.865707	0.063
R-HSA-72764	Eukaryotic Translation Termination	0.865707	0.063
R-HSA-72689	Formation of a pool of free 40S subunits	0.865707	0.063
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.868235	0.061
R-HSA-157118	Signaling by NOTCH	0.869515	0.061
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.870716	0.060
R-HSA-72306	tRNA processing	0.872650	0.059
R-HSA-8957275	Post-translational protein phosphorylation	0.873150	0.059
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.873150	0.059
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.873150	0.059
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.873150	0.059
R-HSA-3214847	HATs acetylate histones	0.875538	0.058
R-HSA-9614085	FOXO-mediated transcription	0.875538	0.058
R-HSA-5610787	Hedgehog 'off' state	0.877882	0.057
R-HSA-913531	Interferon Signaling	0.880066	0.055
R-HSA-2408557	Selenocysteine synthesis	0.880181	0.055
R-HSA-9020702	Interleukin-1 signaling	0.880181	0.055
R-HSA-1483255	PI Metabolism	0.882438	0.054
R-HSA-9675108	Nervous system development	0.884544	0.053
R-HSA-192823	Viral mRNA Translation	0.884652	0.053
R-HSA-9937383	Mitochondrial ribosome-associated quality control	0.884652	0.053
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	0.886824	0.052
R-HSA-112315	Transmission across Chemical Synapses	0.889033	0.051
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.891048	0.050
R-HSA-418346	Platelet homeostasis	0.893100	0.049
R-HSA-9692914	SARS-CoV-1-host interactions	0.893100	0.049
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	0.895114	0.048
R-HSA-69239	Synthesis of DNA	0.895114	0.048
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.897090	0.047
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.897090	0.047
R-HSA-1236975	Antigen processing-Cross presentation	0.897090	0.047
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.897090	0.047
R-HSA-69002	DNA Replication Pre-Initiation	0.899029	0.046
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.899029	0.046
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.900931	0.045
R-HSA-166166	MyD88-independent TLR4 cascade	0.900931	0.045
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.904630	0.044
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.904630	0.044
R-HSA-2871796	FCERI mediated MAPK activation	0.904630	0.044
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.906427	0.043
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.908191	0.042
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.908647	0.042
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.909921	0.041
R-HSA-422475	Axon guidance	0.911409	0.040
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.911619	0.040
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.911619	0.040
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.913285	0.039
R-HSA-72613	Eukaryotic Translation Initiation	0.914920	0.039
R-HSA-72737	Cap-dependent Translation Initiation	0.914920	0.039
R-HSA-373760	L1CAM interactions	0.914920	0.039
R-HSA-2980736	Peptide hormone metabolism	0.916524	0.038
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.918098	0.037
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.919642	0.036
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.919642	0.036
R-HSA-9679506	SARS-CoV Infections	0.919869	0.036
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.924103	0.034
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.924103	0.034
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.925534	0.034
R-HSA-2132295	MHC class II antigen presentation	0.925534	0.034
R-HSA-162909	Host Interactions of HIV factors	0.926939	0.033
R-HSA-69481	G2/M Checkpoints	0.932298	0.030
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.936058	0.029
R-HSA-9717189	Sensory perception of taste	0.938448	0.028
R-HSA-9948299	Ribosome-associated quality control	0.947152	0.024
R-HSA-5368287	Mitochondrial translation	0.947152	0.024
R-HSA-5358351	Signaling by Hedgehog	0.947152	0.024
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.949410	0.023
R-HSA-2187338	Visual phototransduction	0.956327	0.019
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.957152	0.019
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.958756	0.018
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	0.960300	0.018
R-HSA-69306	DNA Replication	0.961050	0.017
R-HSA-9609507	Protein localization	0.961050	0.017
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.964595	0.016
R-HSA-9711097	Cellular response to starvation	0.964595	0.016
R-HSA-877300	Interferon gamma signaling	0.965264	0.015
R-HSA-1428517	Aerobic respiration and respiratory electron transport	0.967319	0.014
R-HSA-2408522	Selenoamino acid metabolism	0.968427	0.014
R-HSA-5619102	SLC transporter disorders	0.970185	0.013
R-HSA-9694516	SARS-CoV-2 Infection	0.970895	0.013
R-HSA-5663205	Infectious disease	0.970975	0.013
R-HSA-416476	G alpha (q) signalling events	0.971104	0.013
R-HSA-9678108	SARS-CoV-1 Infection	0.974894	0.011
R-HSA-611105	Respiratory electron transport	0.976293	0.010
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.978442	0.009
R-HSA-6798695	Neutrophil degranulation	0.980436	0.009
R-HSA-168898	Toll-like Receptor Cascades	0.981511	0.008
R-HSA-1483257	Phospholipid metabolism	0.982585	0.008
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.982619	0.008
R-HSA-112316	Neuronal System	0.983191	0.007
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.985304	0.006
R-HSA-1483206	Glycerophospholipid biosynthesis	0.985304	0.006
R-HSA-425407	SLC-mediated transmembrane transport	0.985910	0.006
R-HSA-597592	Post-translational protein modification	0.986375	0.006
R-HSA-8951664	Neddylation	0.989787	0.004
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.991406	0.004
R-HSA-1280218	Adaptive Immune System	0.991740	0.004
R-HSA-15869	Metabolism of nucleotides	0.992340	0.003
R-HSA-5619115	Disorders of transmembrane transporters	0.993798	0.003
R-HSA-196854	Metabolism of vitamins and cofactors	0.994515	0.002
R-HSA-168249	Innate Immune System	0.996249	0.002
R-HSA-388396	GPCR downstream signalling	0.997676	0.001
R-HSA-72766	Translation	0.998236	0.001
R-HSA-8957322	Metabolism of steroids	0.998591	0.001
R-HSA-1474244	Extracellular matrix organization	0.998769	0.001
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.998879	0.000
R-HSA-168256	Immune System	0.998907	0.000
R-HSA-372790	Signaling by GPCR	0.999276	0.000
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.999643	0.000
R-HSA-1643685	Disease	0.999662	0.000
R-HSA-8978868	Fatty acid metabolism	0.999722	0.000
R-HSA-392499	Metabolism of proteins	0.999886	0.000
R-HSA-500792	GPCR ligand binding	0.999992	0.000
R-HSA-382551	Transport of small molecules	0.999995	0.000
R-HSA-71291	Metabolism of amino acids and derivatives	0.999995	0.000
R-HSA-556833	Metabolism of lipids	0.999999	0.000
R-HSA-9709957	Sensory Perception	1.000000	0.000
R-HSA-1430728	Metabolism	1.000000	-0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CLK3	0.886	0.469	1	0.894
KIS	0.870	0.436	1	0.855
COT	0.867	0.195	2	0.850
HIPK4	0.865	0.388	1	0.865
HIPK2	0.863	0.443	1	0.810
CLK2	0.863	0.361	-3	0.740
SRPK1	0.863	0.275	-3	0.737
NDR2	0.861	0.201	-3	0.842
PIM3	0.861	0.180	-3	0.827
DYRK2	0.860	0.405	1	0.859
MOS	0.859	0.236	1	0.824
CDK1	0.857	0.402	1	0.836
NLK	0.856	0.316	1	0.902
CDK18	0.856	0.417	1	0.814
MTOR	0.856	0.160	1	0.800
CDC7	0.856	0.102	1	0.801
GRK1	0.855	0.243	-2	0.827
ERK5	0.854	0.255	1	0.873
HIPK1	0.854	0.400	1	0.868
SKMLCK	0.853	0.195	-2	0.882
ICK	0.852	0.288	-3	0.811
CDK7	0.852	0.365	1	0.857
JNK2	0.851	0.412	1	0.820
PRKD1	0.851	0.195	-3	0.806
CDKL1	0.851	0.161	-3	0.772
CDK8	0.850	0.348	1	0.844
RSK2	0.850	0.148	-3	0.757
CDK19	0.850	0.367	1	0.822
CDKL5	0.850	0.188	-3	0.767
PRPK	0.849	0.026	-1	0.864
DYRK4	0.849	0.401	1	0.824
PIM1	0.848	0.150	-3	0.773
AURC	0.848	0.174	-2	0.711
P38B	0.848	0.412	1	0.829
PRKD2	0.847	0.163	-3	0.761
CDK5	0.847	0.368	1	0.867
JNK3	0.847	0.385	1	0.839
CLK4	0.846	0.251	-3	0.746
ATR	0.846	0.081	1	0.789
SRPK2	0.846	0.202	-3	0.661
NDR1	0.846	0.089	-3	0.815
IKKB	0.845	-0.008	-2	0.715
CDK17	0.845	0.382	1	0.775
P38G	0.845	0.382	1	0.774
CDK13	0.844	0.337	1	0.838
CDK3	0.844	0.357	1	0.791
CAMK1B	0.843	0.045	-3	0.814
ERK1	0.843	0.375	1	0.824
P90RSK	0.843	0.113	-3	0.756
RAF1	0.843	-0.052	1	0.773
MAK	0.843	0.409	-2	0.818
PKACB	0.843	0.169	-2	0.721
GRK7	0.843	0.197	1	0.741
P38A	0.842	0.373	1	0.870
SRPK3	0.842	0.180	-3	0.701
RSK4	0.842	0.166	-3	0.749
CLK1	0.841	0.249	-3	0.723
CDK10	0.840	0.369	1	0.829
PKACG	0.840	0.105	-2	0.787
CDK12	0.840	0.339	1	0.819
PRKX	0.840	0.180	-3	0.704
BMPR1B	0.839	0.158	1	0.772
CDK14	0.839	0.370	1	0.837
LATS2	0.839	0.079	-5	0.758
CHAK2	0.839	0.057	-1	0.823
MST4	0.839	0.034	2	0.833
BMPR2	0.838	-0.106	-2	0.846
CAMLCK	0.838	0.075	-2	0.854
DYRK1A	0.838	0.310	1	0.873
LATS1	0.838	0.190	-3	0.853
DYRK1B	0.838	0.348	1	0.835
IKKA	0.838	0.045	-2	0.706
CDK16	0.837	0.369	1	0.788
DAPK2	0.837	0.080	-3	0.822
NIK	0.837	0.023	-3	0.828
GRK5	0.837	-0.026	-3	0.807
NUAK2	0.837	0.039	-3	0.821
P38D	0.837	0.392	1	0.785
RSK3	0.837	0.079	-3	0.744
PDHK4	0.837	-0.201	1	0.805
HIPK3	0.836	0.334	1	0.851
TBK1	0.836	-0.080	1	0.664
PKN3	0.836	0.013	-3	0.795
WNK1	0.835	-0.003	-2	0.886
MAPKAPK2	0.835	0.092	-3	0.726
CAMK2G	0.835	-0.072	2	0.795
DSTYK	0.835	-0.090	2	0.873
CDK9	0.835	0.305	1	0.842
PKN2	0.835	0.030	-3	0.802
CAMK2A	0.835	0.112	2	0.801
P70S6KB	0.834	0.061	-3	0.764
PKCD	0.834	0.070	2	0.758
DYRK3	0.833	0.293	1	0.854
AMPKA1	0.833	0.028	-3	0.828
CAMK2D	0.832	0.022	-3	0.795
IKKE	0.832	-0.097	1	0.658
NEK6	0.832	-0.037	-2	0.804
MARK4	0.832	-0.015	4	0.779
RIPK3	0.832	-0.055	3	0.727
MSK1	0.832	0.105	-3	0.729
MAPKAPK3	0.831	0.037	-3	0.757
GCN2	0.831	-0.204	2	0.774
CAMK2B	0.831	0.068	2	0.784
PASK	0.830	0.210	-3	0.850
ERK2	0.830	0.306	1	0.852
MLK1	0.830	-0.094	2	0.786
TGFBR2	0.830	-0.053	-2	0.763
PAK1	0.830	0.054	-2	0.814
GRK6	0.830	-0.018	1	0.776
MLK2	0.830	0.010	2	0.801
AMPKA2	0.829	0.041	-3	0.803
AKT2	0.829	0.113	-3	0.680
PKCB	0.829	0.054	2	0.708
DLK	0.829	-0.057	1	0.771
MSK2	0.828	0.041	-3	0.726
PRP4	0.828	0.219	-3	0.723
MLK3	0.828	0.018	2	0.717
MNK1	0.827	0.096	-2	0.816
MNK2	0.827	0.073	-2	0.807
TSSK2	0.827	0.018	-5	0.847
TSSK1	0.827	0.045	-3	0.848
PKCA	0.827	0.076	2	0.697
PKG2	0.827	0.112	-2	0.729
ULK2	0.827	-0.221	2	0.747
MASTL	0.827	-0.150	-2	0.791
AURB	0.826	0.087	-2	0.703
CK1E	0.826	0.110	-3	0.586
JNK1	0.826	0.332	1	0.811
PDHK1	0.826	-0.243	1	0.774
PRKD3	0.826	0.066	-3	0.721
PKCG	0.825	0.042	2	0.702
TGFBR1	0.825	0.047	-2	0.785
GSK3A	0.825	0.176	4	0.473
HUNK	0.825	-0.142	2	0.782
CDK2	0.825	0.205	1	0.866
PIM2	0.825	0.101	-3	0.724
ALK4	0.824	0.014	-2	0.811
FAM20C	0.824	0.063	2	0.644
MPSK1	0.824	0.229	1	0.754
NEK7	0.823	-0.197	-3	0.791
MYLK4	0.823	0.053	-2	0.797
GRK4	0.823	-0.073	-2	0.819
SGK3	0.823	0.087	-3	0.752
PAK3	0.823	0.007	-2	0.801
MOK	0.823	0.314	1	0.856
BCKDK	0.823	-0.149	-1	0.775
ATM	0.822	-0.023	1	0.727
QSK	0.822	0.014	4	0.755
CK1D	0.821	0.126	-3	0.537
CAMK4	0.821	-0.053	-3	0.787
DNAPK	0.820	0.046	1	0.674
AURA	0.820	0.062	-2	0.672
PKACA	0.820	0.114	-2	0.680
RIPK1	0.820	-0.157	1	0.732
IRE1	0.820	-0.079	1	0.721
PKCZ	0.820	0.008	2	0.743
ACVR2B	0.819	0.014	-2	0.756
VRK2	0.819	-0.040	1	0.826
ALK2	0.818	0.022	-2	0.793
NIM1	0.818	-0.090	3	0.764
MST3	0.818	0.063	2	0.818
YSK4	0.817	-0.084	1	0.715
SMG1	0.817	-0.021	1	0.745
PKR	0.817	-0.066	1	0.765
GRK2	0.817	0.001	-2	0.718
PAK2	0.817	-0.007	-2	0.795
ACVR2A	0.817	-0.010	-2	0.741
NEK9	0.817	-0.212	2	0.796
MEK1	0.816	-0.135	2	0.831
ANKRD3	0.816	-0.196	1	0.774
MLK4	0.816	-0.058	2	0.703
WNK3	0.816	-0.281	1	0.740
CDK6	0.816	0.310	1	0.821
PHKG1	0.815	-0.042	-3	0.799
PAK6	0.815	0.050	-2	0.721
DCAMKL1	0.815	0.024	-3	0.775
ULK1	0.815	-0.242	-3	0.738
TLK2	0.815	-0.039	1	0.725
PKCH	0.815	-0.021	2	0.683
BRSK1	0.814	-0.029	-3	0.765
MELK	0.814	-0.051	-3	0.776
BMPR1A	0.814	0.062	1	0.743
TAO3	0.814	0.049	1	0.748
CDK4	0.814	0.311	1	0.811
MARK3	0.814	-0.016	4	0.704
QIK	0.814	-0.107	-3	0.793
GSK3B	0.813	0.072	4	0.466
TTBK2	0.813	-0.180	2	0.653
AKT1	0.813	0.084	-3	0.703
CK1A2	0.813	0.090	-3	0.539
SIK	0.813	-0.026	-3	0.733
NUAK1	0.813	-0.053	-3	0.763
DRAK1	0.812	-0.037	1	0.722
IRE2	0.811	-0.082	2	0.700
PLK1	0.811	-0.144	-2	0.739
CHK1	0.811	-0.014	-3	0.805
ERK7	0.810	0.107	2	0.525
CHAK1	0.809	-0.142	2	0.747
GAK	0.809	0.082	1	0.810
MEK5	0.809	-0.154	2	0.803
GCK	0.808	0.107	1	0.751
MEKK3	0.808	-0.107	1	0.745
NEK2	0.808	-0.137	2	0.776
AKT3	0.808	0.112	-3	0.633
DAPK3	0.808	0.071	-3	0.778
BRSK2	0.807	-0.087	-3	0.777
BUB1	0.807	0.228	-5	0.811
LKB1	0.807	0.056	-3	0.783
GRK3	0.806	0.010	-2	0.688
MARK2	0.806	-0.071	4	0.669
SGK1	0.806	0.101	-3	0.613
MEKK2	0.806	-0.095	2	0.774
NEK5	0.806	-0.078	1	0.754
SMMLCK	0.806	-0.000	-3	0.774
CAMK1G	0.805	-0.041	-3	0.723
CK1G1	0.805	0.031	-3	0.565
SSTK	0.805	-0.002	4	0.738
BRAF	0.804	-0.132	-4	0.776
ZAK	0.803	-0.144	1	0.706
PLK3	0.803	-0.142	2	0.753
PKCT	0.803	-0.021	2	0.692
P70S6K	0.803	0.004	-3	0.678
DAPK1	0.803	0.062	-3	0.762
PKCE	0.803	0.040	2	0.686
MARK1	0.802	-0.085	4	0.725
HPK1	0.802	0.058	1	0.736
PINK1	0.802	-0.108	1	0.828
ROCK2	0.802	0.107	-3	0.775
PLK4	0.801	-0.121	2	0.586
WNK4	0.801	-0.139	-2	0.869
NEK11	0.801	-0.096	1	0.726
CAMK1D	0.800	0.012	-3	0.673
TNIK	0.800	0.051	3	0.867
MAPKAPK5	0.800	-0.111	-3	0.679
CK2A2	0.800	0.045	1	0.683
DCAMKL2	0.800	-0.052	-3	0.782
MEKK1	0.799	-0.205	1	0.731
PERK	0.799	-0.202	-2	0.792
KHS2	0.798	0.096	1	0.738
IRAK4	0.798	-0.140	1	0.716
SNRK	0.798	-0.210	2	0.642
KHS1	0.797	0.074	1	0.719
PKCI	0.797	-0.035	2	0.709
PDK1	0.797	-0.058	1	0.717
TAO2	0.797	-0.090	2	0.812
TLK1	0.796	-0.156	-2	0.795
SBK	0.796	0.092	-3	0.568
PAK5	0.796	0.005	-2	0.674
MRCKB	0.796	0.062	-3	0.714
MAP3K15	0.796	-0.023	1	0.700
PBK	0.795	0.067	1	0.737
HGK	0.795	-0.021	3	0.863
MEKK6	0.795	-0.079	1	0.742
CAMKK2	0.795	-0.091	-2	0.723
MRCKA	0.794	0.054	-3	0.729
MINK	0.794	-0.040	1	0.724
DMPK1	0.794	0.113	-3	0.740
CAMKK1	0.794	-0.168	-2	0.717
PAK4	0.793	0.016	-2	0.681
HRI	0.792	-0.287	-2	0.798
TAK1	0.792	-0.076	1	0.750
CK2A1	0.792	0.041	1	0.666
MST2	0.792	-0.096	1	0.746
SLK	0.792	-0.019	-2	0.710
EEF2K	0.792	-0.043	3	0.828
NEK8	0.792	-0.189	2	0.777
CHK2	0.791	0.012	-3	0.625
LRRK2	0.791	-0.087	2	0.806
LOK	0.791	-0.029	-2	0.757
NEK4	0.789	-0.137	1	0.718
PHKG2	0.788	-0.116	-3	0.759
CRIK	0.787	0.093	-3	0.706
NEK1	0.787	-0.091	1	0.722
PKN1	0.786	-0.032	-3	0.696
CK1A	0.786	0.085	-3	0.456
PLK2	0.784	-0.061	-3	0.721
CAMK1A	0.784	0.004	-3	0.641
VRK1	0.783	-0.175	2	0.793
PDHK3_TYR	0.783	0.358	4	0.860
HASPIN	0.783	0.032	-1	0.719
ROCK1	0.783	0.051	-3	0.728
OSR1	0.782	-0.018	2	0.784
MST1	0.782	-0.121	1	0.723
YSK1	0.780	-0.106	2	0.772
PDHK4_TYR	0.779	0.272	2	0.880
STK33	0.778	-0.161	2	0.580
PKG1	0.778	0.014	-2	0.651
TTBK1	0.778	-0.240	2	0.569
IRAK1	0.777	-0.352	-1	0.728
TTK	0.774	-0.081	-2	0.775
TESK1_TYR	0.774	0.152	3	0.877
YANK3	0.774	-0.045	2	0.382
MAP2K6_TYR	0.773	0.147	-1	0.860
MAP2K4_TYR	0.773	0.156	-1	0.862
MEK2	0.772	-0.287	2	0.786
MYO3B	0.772	-0.053	2	0.793
BIKE	0.771	0.016	1	0.707
LIMK2_TYR	0.770	0.159	-3	0.838
ASK1	0.770	-0.113	1	0.688
ALPHAK3	0.769	-0.039	-1	0.769
PDHK1_TYR	0.768	0.084	-1	0.855
PKMYT1_TYR	0.768	0.079	3	0.844
BMPR2_TYR	0.768	0.068	-1	0.852
MAP2K7_TYR	0.766	-0.049	2	0.837
MYO3A	0.765	-0.103	1	0.711
RIPK2	0.765	-0.338	1	0.660
TAO1	0.764	-0.120	1	0.664
NEK3	0.762	-0.232	1	0.689
AAK1	0.762	0.078	1	0.627
PINK1_TYR	0.759	-0.171	1	0.793
EPHA6	0.758	0.004	-1	0.818
TXK	0.758	0.091	1	0.788
EPHB4	0.757	0.010	-1	0.798
RET	0.756	-0.072	1	0.740
CK1G3	0.755	0.038	-3	0.413
ABL2	0.755	0.029	-1	0.779
LIMK1_TYR	0.754	-0.118	2	0.817
STLK3	0.752	-0.202	1	0.679
TYRO3	0.752	-0.098	3	0.785
FGR	0.752	-0.029	1	0.795
ROS1	0.751	-0.089	3	0.750
MST1R	0.751	-0.119	3	0.799
CSF1R	0.750	-0.072	3	0.777
ABL1	0.750	-0.010	-1	0.769
TNK2	0.749	-0.003	3	0.735
YES1	0.749	-0.062	-1	0.805
FER	0.748	-0.106	1	0.807
JAK2	0.748	-0.117	1	0.731
LCK	0.748	0.010	-1	0.792
EPHA4	0.747	-0.036	2	0.766
INSRR	0.747	-0.094	3	0.727
TYK2	0.746	-0.220	1	0.728
JAK3	0.746	-0.113	1	0.726
DDR1	0.746	-0.170	4	0.760
ITK	0.745	-0.047	-1	0.764
SRMS	0.745	-0.070	1	0.786
BLK	0.744	0.009	-1	0.784
BMX	0.744	0.001	-1	0.723
TNK1	0.743	-0.043	3	0.771
HCK	0.743	-0.091	-1	0.787
EPHB1	0.743	-0.086	1	0.777
KIT	0.743	-0.095	3	0.780
KDR	0.743	-0.079	3	0.739
MET	0.743	-0.044	3	0.774
NEK10_TYR	0.743	-0.082	1	0.646
FGFR2	0.742	-0.122	3	0.780
MERTK	0.742	-0.063	3	0.763
CK1G2	0.742	0.035	-3	0.494
FYN	0.741	0.017	-1	0.777
YANK2	0.741	-0.071	2	0.399
EPHB3	0.741	-0.084	-1	0.779
JAK1	0.740	-0.054	1	0.675
EPHB2	0.739	-0.085	-1	0.769
TNNI3K_TYR	0.738	-0.049	1	0.737
AXL	0.737	-0.135	3	0.759
WEE1_TYR	0.737	-0.084	-1	0.768
TEK	0.737	-0.134	3	0.717
TEC	0.736	-0.108	-1	0.702
FLT1	0.735	-0.104	-1	0.786
PDGFRB	0.734	-0.233	3	0.786
FGFR3	0.734	-0.114	3	0.750
EPHA7	0.734	-0.079	2	0.756
DDR2	0.734	-0.023	3	0.705
FGFR1	0.733	-0.176	3	0.743
FLT3	0.733	-0.229	3	0.785
EPHA3	0.732	-0.126	2	0.731
SYK	0.731	0.041	-1	0.749
PTK2	0.731	0.020	-1	0.743
ALK	0.730	-0.163	3	0.689
PTK2B	0.730	-0.060	-1	0.737
LTK	0.730	-0.160	3	0.713
MATK	0.729	-0.091	-1	0.723
BTK	0.729	-0.234	-1	0.736
LYN	0.729	-0.104	3	0.702
ERBB2	0.729	-0.175	1	0.699
PTK6	0.728	-0.215	-1	0.722
EPHA5	0.728	-0.088	2	0.752
NTRK1	0.727	-0.226	-1	0.796
NTRK3	0.727	-0.123	-1	0.770
EPHA1	0.727	-0.151	3	0.753
INSR	0.727	-0.177	3	0.708
SRC	0.726	-0.088	-1	0.769
PDGFRA	0.726	-0.277	3	0.784
FRK	0.725	-0.154	-1	0.784
EPHA8	0.724	-0.103	-1	0.767
ZAP70	0.723	0.063	-1	0.711
EGFR	0.723	-0.105	1	0.613
FGFR4	0.722	-0.096	-1	0.747
FLT4	0.722	-0.232	3	0.733
NTRK2	0.721	-0.264	3	0.736
CSK	0.720	-0.161	2	0.756
EPHA2	0.717	-0.084	-1	0.742
ERBB4	0.715	-0.065	1	0.638
IGF1R	0.712	-0.163	3	0.649
MUSK	0.706	-0.194	1	0.607
FES	0.700	-0.150	-1	0.702