Motif 182 (n=96)

Position-wise Probabilities

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uniprot genes site source protein function
H0Y626 None S27 ochoa RING-type E3 ubiquitin transferase (EC 2.3.2.27) None
O14828 SCAMP3 S72 ochoa Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
O15417 TNRC18 S2375 ochoa Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) None
O75161 NPHP4 S481 ochoa Nephrocystin-4 (Nephroretinin) Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}.
O75175 CNOT3 S513 ochoa CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}.
O75381 PEX14 S271 ochoa Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}.
O95361 TRIM16 S27 ochoa Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}.
P10636 MAPT S420 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P10636 MAPT S508 ochoa Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P10636 MAPT S515 ochoa|psp Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.
P11137 MAP2 S1598 ochoa Microtubule-associated protein 2 (MAP-2) The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
P13807 GYS1 Y634 ochoa|psp Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}.
P17302 GJA1 Y265 psp Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
P24928 POLR2A Y1615 psp DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1839 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1846 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1853 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1860 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1867 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1874 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1881 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1888 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1895 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1902 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1909 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1916 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1923 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A Y1930 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P24928 POLR2A T1933 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P50548 ERF S150 ochoa ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}.
P54259 ATN1 S174 ochoa Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}.
P57682 KLF3 Y107 ochoa Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}.
P85037 FOXK1 S239 ochoa Forkhead box protein K1 (Myocyte nuclear factor) (MNF) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}.
P85037 FOXK1 S249 ochoa Forkhead box protein K1 (Myocyte nuclear factor) (MNF) Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}.
Q05193 DNM1 S774 psp Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}.
Q05193 DNM1 S795 psp Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}.
Q07889 SOS1 S1203 ochoa Son of sevenless homolog 1 (SOS-1) Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}.
Q07912 TNK2 S774 ochoa Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
Q13112 CHAF1B S513 ochoa Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}.
Q13136 PPFIA1 S697 ochoa Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.
Q14207 NPAT S1302 ochoa Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.
Q15691 MAPRE1 S165 ochoa Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}.
Q16204 CCDC6 S384 ochoa Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) None
Q3KQU3 MAP7D1 S41 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q3KQU3 MAP7D1 S112 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q3KQU3 MAP7D1 S479 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q4VCS5 AMOT S328 ochoa Angiomotin Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}.
Q5T5P2 KIAA1217 S322 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q68CZ2 TNS3 S873 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q6F5E8 CARMIL2 T1412 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6IQ23 PLEKHA7 S867 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6IQ23 PLEKHA7 Y888 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6P0Q8 MAST2 S1340 ochoa Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6PKG0 LARP1 Y777 ochoa La-related protein 1 (La ribonucleoprotein domain family member 1) RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
Q70E73 RAPH1 S845 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q70E73 RAPH1 S1094 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q7Z5L9 IRF2BP2 S395 ochoa Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.
Q7Z5L9 IRF2BP2 S409 ochoa Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}.
Q86WR7 PROSER2 S166 ochoa Proline and serine-rich protein 2 None
Q86X29 LSR Y328 ochoa Lipolysis-stimulated lipoprotein receptor (Angulin-1) Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}.
Q8IYB3 SRRM1 S773 ochoa Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q8IZP0 ABI1 Y198 ochoa Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q8N3V7 SYNPO Y789 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8TEY7 USP33 S443 ochoa Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}.
Q8WUF5 PPP1R13L S73 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WUF5 PPP1R13L Y109 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WWM7 ATXN2L S434 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WWM7 ATXN2L S630 ochoa Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
Q8WXF1 PSPC1 S473 ochoa Paraspeckle component 1 (Paraspeckle protein 1) RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.
Q93052 LPP S155 ochoa Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
Q96JH7 VCPIP1 S757 ochoa Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}.
Q96JM3 CHAMP1 S372 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96JM3 CHAMP1 S382 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96ST3 SIN3A S263 ochoa Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}.
Q96ST3 SIN3A T266 ochoa Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}.
Q9BQI5 SGIP1 S482 ochoa SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}.
Q9BUL9 RPP25 Y151 ochoa Ribonuclease P protein subunit p25 (RNase P protein subunit p25) Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:16723659, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}.
Q9C0B0 UNK S374 ochoa RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9H4L4 SENP3 S54 ochoa Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}.
Q9H5H4 ZNF768 S107 ochoa Zinc finger protein 768 Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}.
Q9H5H4 ZNF768 Y121 ochoa Zinc finger protein 768 Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}.
Q9H792 PEAK1 S819 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9H792 PEAK1 S864 ochoa Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}.
Q9HDC5 JPH1 S465 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NYB9 ABI2 Y198 ochoa Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
Q9P0K7 RAI14 S296 ochoa Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}.
Q9P1Y5 CAMSAP3 S347 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9UGJ0 PRKAG2 S90 ochoa 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}.
Q9UGP4 LIMD1 S214 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UJM3 ERRFI1 S276 ochoa ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}.
Q9UMS6 SYNPO2 S770 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UMS6 SYNPO2 S777 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UQ35 SRRM2 S387 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S404 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9Y4F5 CEP170B S721 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Q9Y4F5 CEP170B S875 ochoa Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.
Download
reactome_id name p -log10_p
R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.016507 1.782
R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.016507 1.782
R-HSA-196025 Formation of annular gap junctions 0.001002 2.999
R-HSA-190873 Gap junction degradation 0.001189 2.925
R-HSA-191650 Regulation of gap junction activity 0.024660 1.608
R-HSA-112412 SOS-mediated signalling 0.040766 1.390
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.044751 1.349
R-HSA-179812 GRB2 events in EGFR signaling 0.064435 1.191
R-HSA-9619483 Activation of AMPK downstream of NMDARs 0.008999 2.046
R-HSA-1963640 GRB2 events in ERBB2 signaling 0.083719 1.077
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.087528 1.058
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.095101 1.022
R-HSA-6803529 FGFR2 alternative splicing 0.110060 0.958
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.113762 0.944
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.113762 0.944
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.128417 0.891
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.128417 0.891
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.132044 0.879
R-HSA-113418 Formation of the Early Elongation Complex 0.132044 0.879
R-HSA-167287 HIV elongation arrest and recovery 0.132044 0.879
R-HSA-167290 Pausing and recovery of HIV elongation 0.132044 0.879
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.177856 0.750
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.184689 0.734
R-HSA-167161 HIV Transcription Initiation 0.184689 0.734
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.184689 0.734
R-HSA-73776 RNA Polymerase II Promoter Escape 0.191467 0.718
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.198188 0.703
R-HSA-72172 mRNA Splicing 0.066942 1.174
R-HSA-167169 HIV Transcription Elongation 0.177856 0.750
R-HSA-72086 mRNA Capping 0.135655 0.868
R-HSA-72163 mRNA Splicing - Major Pathway 0.059403 1.226
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.064276 1.192
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.177856 0.750
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.174418 0.758
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.048720 1.312
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.139252 0.856
R-HSA-157858 Gap junction trafficking and regulation 0.023794 1.624
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.128608 0.891
R-HSA-190872 Transport of connexons to the plasma membrane 0.091322 1.039
R-HSA-190828 Gap junction trafficking 0.020067 1.698
R-HSA-2424491 DAP12 signaling 0.139252 0.856
R-HSA-8851805 MET activates RAS signaling 0.064435 1.191
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.177856 0.750
R-HSA-74749 Signal attenuation 0.052673 1.278
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.181280 0.742
R-HSA-190861 Gap junction assembly 0.157016 0.804
R-HSA-8856828 Clathrin-mediated endocytosis 0.029811 1.526
R-HSA-190827 Transport of connexins along the secretory pathway 0.012406 1.906
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.020592 1.686
R-HSA-8875513 MET interacts with TNS proteins 0.020592 1.686
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.052673 1.278
R-HSA-9034864 Activated NTRK3 signals through RAS 0.056610 1.247
R-HSA-9026519 Activated NTRK2 signals through RAS 0.060530 1.218
R-HSA-428540 Activation of RAC1 0.060530 1.218
R-HSA-180336 SHC1 events in EGFR signaling 0.076053 1.119
R-HSA-9603798 Class I peroxisomal membrane protein import 0.079894 1.097
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.079894 1.097
R-HSA-1250347 SHC1 events in ERBB4 signaling 0.083719 1.077
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.091322 1.039
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.095101 1.022
R-HSA-3322077 Glycogen synthesis 0.098864 1.005
R-HSA-5654704 SHC-mediated cascade:FGFR3 0.102611 0.989
R-HSA-5654719 SHC-mediated cascade:FGFR4 0.106343 0.973
R-HSA-5654688 SHC-mediated cascade:FGFR1 0.117448 0.930
R-HSA-5654699 SHC-mediated cascade:FGFR2 0.128417 0.891
R-HSA-427413 NoRC negatively regulates rRNA expression 0.043130 1.365
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.044472 1.352
R-HSA-2428933 SHC-related events triggered by IGF1R 0.064435 1.191
R-HSA-3229121 Glycogen storage diseases 0.087528 1.058
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.110060 0.958
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.040233 1.395
R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling 0.076053 1.119
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.095101 1.022
R-HSA-190704 Oligomerization of connexins into connexons 0.012406 1.906
R-HSA-8964046 VLDL clearance 0.040766 1.390
R-HSA-2179392 EGFR Transactivation by Gastrin 0.052673 1.278
R-HSA-177504 Retrograde neurotrophin signalling 0.072196 1.141
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.102611 0.989
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.117448 0.930
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.139252 0.856
R-HSA-2172127 DAP12 interactions 0.194834 0.710
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.117448 0.930
R-HSA-8982491 Glycogen metabolism 0.177856 0.750
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 0.064435 1.191
R-HSA-9673770 Signaling by PDGFRA extracellular domain mutants 0.076053 1.119
R-HSA-9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 0.076053 1.119
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.091322 1.039
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.024660 1.608
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.052673 1.278
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.064435 1.191
R-HSA-9027284 Erythropoietin activates RAS 0.076053 1.119
R-HSA-429947 Deadenylation of mRNA 0.117448 0.930
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.124776 0.904
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.052269 1.282
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.177856 0.750
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.140557 0.852
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.135655 0.868
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.139252 0.856
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.087528 1.058
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.087528 1.058
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.095101 1.022
R-HSA-5654706 FRS-mediated FGFR3 signaling 0.106343 0.973
R-HSA-5654712 FRS-mediated FGFR4 signaling 0.110060 0.958
R-HSA-5654693 FRS-mediated FGFR1 signaling 0.121120 0.917
R-HSA-5654700 FRS-mediated FGFR2 signaling 0.132044 0.879
R-HSA-9664417 Leishmania phagocytosis 0.139139 0.857
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.139139 0.857
R-HSA-9664407 Parasite infection 0.139139 0.857
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.157016 0.804
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.162181 0.790
R-HSA-2559585 Oncogene Induced Senescence 0.160525 0.794
R-HSA-9842663 Signaling by LTK 0.002091 2.680
R-HSA-9613354 Lipophagy 0.048720 1.312
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.064435 1.191
R-HSA-9005895 Pervasive developmental disorders 0.064435 1.191
R-HSA-9697154 Disorders of Nervous System Development 0.064435 1.191
R-HSA-167044 Signalling to RAS 0.102611 0.989
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.055472 1.256
R-HSA-8953854 Metabolism of RNA 0.064781 1.189
R-HSA-1643713 Signaling by EGFR in Cancer 0.124776 0.904
R-HSA-9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... 0.110060 0.958
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.102611 0.989
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.102611 0.989
R-HSA-5654708 Downstream signaling of activated FGFR3 0.135655 0.868
R-HSA-5654716 Downstream signaling of activated FGFR4 0.139252 0.856
R-HSA-5654696 Downstream signaling of activated FGFR2 0.160525 0.794
R-HSA-5654738 Signaling by FGFR2 0.052269 1.282
R-HSA-165159 MTOR signalling 0.188085 0.726
R-HSA-199991 Membrane Trafficking 0.145716 0.836
R-HSA-2028269 Signaling by Hippo 0.003890 2.410
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.079894 1.097
R-HSA-9675151 Disorders of Developmental Biology 0.083719 1.077
R-HSA-9671555 Signaling by PDGFR in disease 0.106343 0.973
R-HSA-912526 Interleukin receptor SHC signaling 0.113762 0.944
R-HSA-5654687 Downstream signaling of activated FGFR1 0.160525 0.794
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.124776 0.904
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.157806 0.802
R-HSA-210993 Tie2 Signaling 0.091322 1.039
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.191859 0.717
R-HSA-190236 Signaling by FGFR 0.075913 1.120
R-HSA-6806834 Signaling by MET 0.052269 1.282
R-HSA-72312 rRNA processing 0.087980 1.056
R-HSA-5655291 Signaling by FGFR4 in disease 0.072196 1.141
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.102611 0.989
R-HSA-1433559 Regulation of KIT signaling 0.072196 1.141
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.121120 0.917
R-HSA-186763 Downstream signal transduction 0.142834 0.845
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.124776 0.904
R-HSA-5655253 Signaling by FGFR2 in disease 0.024571 1.610
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.106343 0.973
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.128417 0.891
R-HSA-1852241 Organelle biogenesis and maintenance 0.168513 0.773
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.048720 1.312
R-HSA-9762292 Regulation of CDH11 function 0.052673 1.278
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.068323 1.165
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 0.106343 0.973
R-HSA-200425 Carnitine shuttle 0.113762 0.944
R-HSA-5654743 Signaling by FGFR4 0.191467 0.718
R-HSA-5655332 Signaling by FGFR3 in disease 0.128417 0.891
R-HSA-201556 Signaling by ALK 0.174418 0.758
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.004750 2.323
R-HSA-5654741 Signaling by FGFR3 0.198188 0.703
R-HSA-1226099 Signaling by FGFR in disease 0.046104 1.336
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.117448 0.930
R-HSA-8853659 RET signaling 0.164020 0.785
R-HSA-8875878 MET promotes cell motility 0.170966 0.767
R-HSA-376176 Signaling by ROBO receptors 0.065540 1.183
R-HSA-9006335 Signaling by Erythropoietin 0.135655 0.868
R-HSA-112315 Transmission across Chemical Synapses 0.171567 0.766
R-HSA-9669938 Signaling by KIT in disease 0.110060 0.958
R-HSA-9682385 FLT3 signaling in disease 0.164020 0.785
R-HSA-438064 Post NMDA receptor activation events 0.060915 1.215
R-HSA-1433557 Signaling by SCF-KIT 0.191467 0.718
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.110060 0.958
R-HSA-9022692 Regulation of MECP2 expression and activity 0.149954 0.824
R-HSA-5689896 Ovarian tumor domain proteases 0.167500 0.776
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.121120 0.917
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.083193 1.080
R-HSA-5688426 Deubiquitination 0.107093 0.970
R-HSA-187687 Signalling to ERKs 0.160525 0.794
R-HSA-8983432 Interleukin-15 signaling 0.064435 1.191
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.184689 0.734
R-HSA-5655302 Signaling by FGFR1 in disease 0.184689 0.734
R-HSA-1839126 FGFR2 mutant receptor activation 0.164020 0.785
R-HSA-8964043 Plasma lipoprotein clearance 0.174418 0.758
R-HSA-166520 Signaling by NTRKs 0.152011 0.818
R-HSA-8964038 LDL clearance 0.110060 0.958
R-HSA-9607240 FLT3 Signaling 0.181280 0.742
R-HSA-162582 Signal Transduction 0.187905 0.726
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.080742 1.093
R-HSA-354192 Integrin signaling 0.149954 0.824
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.198188 0.703
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.135655 0.868
R-HSA-451927 Interleukin-2 family signaling 0.177856 0.750
R-HSA-3700989 Transcriptional Regulation by TP53 0.144119 0.841
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.149954 0.824
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.119654 0.922
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.146401 0.834
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.188085 0.726
R-HSA-5633007 Regulation of TP53 Activity 0.169521 0.771
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.100952 0.996
R-HSA-194138 Signaling by VEGF 0.115575 0.937
R-HSA-168255 Influenza Infection 0.199394 0.700
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.201529 0.696
R-HSA-72165 mRNA Splicing - Minor Pathway 0.201529 0.696
R-HSA-75153 Apoptotic execution phase 0.201529 0.696
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.204855 0.689
R-HSA-437239 Recycling pathway of L1 0.204855 0.689
R-HSA-422475 Axon guidance 0.209487 0.679
R-HSA-5617833 Cilium Assembly 0.216094 0.665
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.218025 0.661
R-HSA-72187 mRNA 3'-end processing 0.221284 0.655
R-HSA-112382 Formation of RNA Pol II elongation complex 0.221284 0.655
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.221284 0.655
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.221284 0.655
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.224530 0.649
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.234186 0.630
R-HSA-193648 NRAGE signals death through JNK 0.234186 0.630
R-HSA-177929 Signaling by EGFR 0.234186 0.630
R-HSA-5654736 Signaling by FGFR1 0.234186 0.630
R-HSA-112399 IRS-mediated signalling 0.237379 0.625
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.237379 0.625
R-HSA-6782135 Dual incision in TC-NER 0.240558 0.619
R-HSA-9675108 Nervous system development 0.242274 0.616
R-HSA-9033241 Peroxisomal protein import 0.243724 0.613
R-HSA-429914 Deadenylation-dependent mRNA decay 0.243724 0.613
R-HSA-8943724 Regulation of PTEN gene transcription 0.246878 0.608
R-HSA-1227986 Signaling by ERBB2 0.246878 0.608
R-HSA-73856 RNA Polymerase II Transcription Termination 0.250018 0.602
R-HSA-2428928 IRS-related events triggered by IGF1R 0.250018 0.602
R-HSA-168325 Viral Messenger RNA Synthesis 0.250018 0.602
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.251374 0.600
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.253146 0.597
R-HSA-6784531 tRNA processing in the nucleus 0.253146 0.597
R-HSA-375165 NCAM signaling for neurite out-growth 0.253146 0.597
R-HSA-186797 Signaling by PDGF 0.253146 0.597
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.256260 0.591
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.256260 0.591
R-HSA-74751 Insulin receptor signalling cascade 0.259362 0.586
R-HSA-2428924 IGF1R signaling cascade 0.259362 0.586
R-HSA-5653656 Vesicle-mediated transport 0.262193 0.581
R-HSA-1234174 Cellular response to hypoxia 0.262451 0.581
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.262451 0.581
R-HSA-8854518 AURKA Activation by TPX2 0.265527 0.576
R-HSA-167172 Transcription of the HIV genome 0.271642 0.566
R-HSA-8878171 Transcriptional regulation by RUNX1 0.272959 0.564
R-HSA-9705683 SARS-CoV-2-host interactions 0.276043 0.559
R-HSA-5578749 Transcriptional regulation by small RNAs 0.283722 0.547
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.286711 0.543
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.286711 0.543
R-HSA-5663084 Diseases of carbohydrate metabolism 0.286711 0.543
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.286711 0.543
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.286711 0.543
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.289688 0.538
R-HSA-1236394 Signaling by ERBB4 0.289688 0.538
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.292652 0.534
R-HSA-380287 Centrosome maturation 0.292652 0.534
R-HSA-8852135 Protein ubiquitination 0.292652 0.534
R-HSA-5689603 UCH proteinases 0.295604 0.529
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.301472 0.521
R-HSA-416482 G alpha (12/13) signalling events 0.301472 0.521
R-HSA-9833482 PKR-mediated signaling 0.307292 0.512
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.313064 0.504
R-HSA-9707564 Cytoprotection by HMOX1 0.315933 0.500
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.318789 0.496
R-HSA-6794362 Protein-protein interactions at synapses 0.321634 0.493
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.324467 0.489
R-HSA-141424 Amplification of signal from the kinetochores 0.324467 0.489
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.324467 0.489
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.327288 0.485
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.327288 0.485
R-HSA-112316 Neuronal System 0.332809 0.478
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.332896 0.478
R-HSA-156902 Peptide chain elongation 0.332896 0.478
R-HSA-9663891 Selective autophagy 0.332896 0.478
R-HSA-112310 Neurotransmitter release cycle 0.338458 0.470
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 0.341222 0.467
R-HSA-8986944 Transcriptional Regulation by MECP2 0.341222 0.467
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.343975 0.463
R-HSA-156842 Eukaryotic Translation Elongation 0.346716 0.460
R-HSA-74752 Signaling by Insulin receptor 0.346716 0.460
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.346716 0.460
R-HSA-2682334 EPH-Ephrin signaling 0.346716 0.460
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.349445 0.457
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 0.354871 0.450
R-HSA-9824443 Parasitic Infection Pathways 0.357062 0.447
R-HSA-9658195 Leishmania infection 0.357062 0.447
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.357568 0.447
R-HSA-72764 Eukaryotic Translation Termination 0.357568 0.447
R-HSA-72689 Formation of a pool of free 40S subunits 0.357568 0.447
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.360253 0.443
R-HSA-157579 Telomere Maintenance 0.362927 0.440
R-HSA-9614085 FOXO-mediated transcription 0.368242 0.434
R-HSA-193704 p75 NTR receptor-mediated signalling 0.368242 0.434
R-HSA-69618 Mitotic Spindle Checkpoint 0.370883 0.431
R-HSA-2408557 Selenocysteine synthesis 0.373514 0.428
R-HSA-192823 Viral mRNA Translation 0.378742 0.422
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.381340 0.419
R-HSA-5619507 Activation of HOX genes during differentiation 0.383927 0.416
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.383927 0.416
R-HSA-5696398 Nucleotide Excision Repair 0.386504 0.413
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.391625 0.407
R-HSA-211000 Gene Silencing by RNA 0.391625 0.407
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.394170 0.404
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.394170 0.404
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.396704 0.402
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.404245 0.393
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.404245 0.393
R-HSA-2871796 FCERI mediated MAPK activation 0.404245 0.393
R-HSA-9855142 Cellular responses to mechanical stimuli 0.409220 0.388
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.414155 0.383
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.416607 0.380
R-HSA-72613 Eukaryotic Translation Initiation 0.419049 0.378
R-HSA-72737 Cap-dependent Translation Initiation 0.419049 0.378
R-HSA-373760 L1CAM interactions 0.419049 0.378
R-HSA-212165 Epigenetic regulation of gene expression 0.419067 0.378
R-HSA-1592230 Mitochondrial biogenesis 0.421480 0.375
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.431108 0.365
R-HSA-73886 Chromosome Maintenance 0.431108 0.365
R-HSA-9679506 SARS-CoV Infections 0.431275 0.365
R-HSA-2132295 MHC class II antigen presentation 0.435862 0.361
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.435862 0.361
R-HSA-9694516 SARS-CoV-2 Infection 0.455971 0.341
R-HSA-9018519 Estrogen-dependent gene expression 0.472514 0.326
R-HSA-163685 Integration of energy metabolism 0.472514 0.326
R-HSA-9948299 Ribosome-associated quality control 0.476927 0.322
R-HSA-6807070 PTEN Regulation 0.479120 0.320
R-HSA-1632852 Macroautophagy 0.483479 0.316
R-HSA-162599 Late Phase of HIV Life Cycle 0.487802 0.312
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.487802 0.312
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.500558 0.301
R-HSA-9856651 MITF-M-dependent gene expression 0.504740 0.297
R-HSA-9679191 Potential therapeutics for SARS 0.504740 0.297
R-HSA-9609507 Protein localization 0.510948 0.292
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.513001 0.290
R-HSA-73887 Death Receptor Signaling 0.513001 0.290
R-HSA-9612973 Autophagy 0.517080 0.286
R-HSA-162587 HIV Life Cycle 0.519107 0.285
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.519107 0.285
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.521126 0.283
R-HSA-9711097 Cellular response to starvation 0.521126 0.283
R-HSA-9824446 Viral Infection Pathways 0.524713 0.280
R-HSA-109581 Apoptosis 0.529117 0.276
R-HSA-2467813 Separation of Sister Chromatids 0.533064 0.273
R-HSA-2408522 Selenoamino acid metabolism 0.533064 0.273
R-HSA-8953897 Cellular responses to stimuli 0.538846 0.269
R-HSA-72306 tRNA processing 0.546621 0.262
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.550423 0.259
R-HSA-5689880 Ub-specific processing proteases 0.552312 0.258
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.556066 0.255
R-HSA-2559583 Cellular Senescence 0.565318 0.248
R-HSA-69275 G2/M Transition 0.576170 0.239
R-HSA-5663205 Infectious disease 0.577778 0.238
R-HSA-73857 RNA Polymerase II Transcription 0.579705 0.237
R-HSA-453274 Mitotic G2-G2/M phases 0.579727 0.237
R-HSA-168898 Toll-like Receptor Cascades 0.585009 0.233
R-HSA-68877 Mitotic Prometaphase 0.588493 0.230
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.593666 0.226
R-HSA-389948 Co-inhibition by PD-1 0.600463 0.222
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.605488 0.218
R-HSA-5357801 Programmed Cell Death 0.610450 0.214
R-HSA-9730414 MITF-M-regulated melanocyte development 0.623384 0.205
R-HSA-68882 Mitotic Anaphase 0.628124 0.202
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.629691 0.201
R-HSA-418990 Adherens junctions interactions 0.631252 0.200
R-HSA-2262752 Cellular responses to stress 0.634860 0.197
R-HSA-162906 HIV Infection 0.645008 0.190
R-HSA-212436 Generic Transcription Pathway 0.648927 0.188
R-HSA-1280218 Adaptive Immune System 0.655900 0.183
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.657705 0.182
R-HSA-202733 Cell surface interactions at the vascular wall 0.659700 0.181
R-HSA-8939211 ESR-mediated signaling 0.659700 0.181
R-HSA-421270 Cell-cell junction organization 0.679268 0.168
R-HSA-388841 Regulation of T cell activation by CD28 family 0.685984 0.164
R-HSA-69620 Cell Cycle Checkpoints 0.688632 0.162
R-HSA-416476 G alpha (q) signalling events 0.696443 0.157
R-HSA-9711123 Cellular response to chemical stress 0.701544 0.154
R-HSA-76002 Platelet activation, signaling and aggregation 0.709036 0.149
R-HSA-446728 Cell junction organization 0.713927 0.146
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.718738 0.143
R-HSA-1266738 Developmental Biology 0.725718 0.139
R-HSA-5673001 RAF/MAP kinase cascade 0.726965 0.138
R-HSA-1257604 PIP3 activates AKT signaling 0.733828 0.134
R-HSA-5684996 MAPK1/MAPK3 signaling 0.734956 0.134
R-HSA-74160 Gene expression (Transcription) 0.736689 0.133
R-HSA-1500931 Cell-Cell communication 0.756537 0.121
R-HSA-9006925 Intracellular signaling by second messengers 0.782023 0.107
R-HSA-5683057 MAPK family signaling cascades 0.786614 0.104
R-HSA-73894 DNA Repair 0.798109 0.098
R-HSA-9006931 Signaling by Nuclear Receptors 0.800673 0.097
R-HSA-1640170 Cell Cycle 0.812574 0.090
R-HSA-68886 M Phase 0.816970 0.088
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.817750 0.087
R-HSA-913531 Interferon Signaling 0.817750 0.087
R-HSA-168249 Innate Immune System 0.823367 0.084
R-HSA-8978868 Fatty acid metabolism 0.835506 0.078
R-HSA-597592 Post-translational protein modification 0.840947 0.075
R-HSA-5668914 Diseases of metabolism 0.848992 0.071
R-HSA-72766 Translation 0.850279 0.070
R-HSA-109582 Hemostasis 0.854305 0.068
R-HSA-1643685 Disease 0.861715 0.065
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.866060 0.062
R-HSA-69278 Cell Cycle, Mitotic 0.916921 0.038
R-HSA-71291 Metabolism of amino acids and derivatives 0.933655 0.030
R-HSA-449147 Signaling by Interleukins 0.935637 0.029
R-HSA-1280215 Cytokine Signaling in Immune system 0.947414 0.023
R-HSA-392499 Metabolism of proteins 0.950830 0.022
R-HSA-168256 Immune System 0.958478 0.018
R-HSA-388396 GPCR downstream signalling 0.966366 0.015
R-HSA-372790 Signaling by GPCR 0.976634 0.010
R-HSA-382551 Transport of small molecules 0.986491 0.006
R-HSA-556833 Metabolism of lipids 0.989134 0.005
R-HSA-1430728 Metabolism 0.999972 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.747 0.269 1 0.796
GSK3AGSK3A 0.743 0.386 4 0.768
GRK1GRK1 0.737 0.261 -2 0.591
HIPK4HIPK4 0.735 0.283 1 0.768
MAKMAK 0.730 0.351 -2 0.889
HIPK2HIPK2 0.729 0.223 1 0.679
KISKIS 0.729 0.173 1 0.705
COTCOT 0.729 0.154 2 0.694
GSK3BGSK3B 0.728 0.344 4 0.769
MOSMOS 0.726 0.239 1 0.800
CDC7CDC7 0.725 0.224 1 0.803
GRK7GRK7 0.723 0.229 1 0.697
PIM3PIM3 0.723 0.131 -3 0.687
ICKICK 0.723 0.279 -3 0.667
SKMLCKSKMLCK 0.722 0.164 -2 0.643
CLK2CLK2 0.721 0.162 -3 0.594
CK1ECK1E 0.721 0.233 -3 0.762
CK1DCK1D 0.720 0.241 -3 0.738
DYRK2DYRK2 0.720 0.170 1 0.741
CDK1CDK1 0.719 0.175 1 0.706
CDK18CDK18 0.719 0.189 1 0.667
CDKL5CDKL5 0.717 0.193 -3 0.622
CK1A2CK1A2 0.716 0.232 -3 0.736
NDR2NDR2 0.716 0.104 -3 0.696
SRPK1SRPK1 0.715 0.093 -3 0.607
CDKL1CDKL1 0.714 0.152 -3 0.633
CHAK2CHAK2 0.714 0.203 -1 0.884
P38BP38B 0.713 0.232 1 0.675
HIPK1HIPK1 0.713 0.161 1 0.748
GRK5GRK5 0.712 0.164 -3 0.736
CK1ACK1A 0.712 0.261 -3 0.690
PIM1PIM1 0.711 0.092 -3 0.637
MTORMTOR 0.711 0.150 1 0.676
DYRK4DYRK4 0.710 0.155 1 0.688
CDK19CDK19 0.709 0.188 1 0.672
CAMK2ACAMK2A 0.708 0.136 2 0.640
AURCAURC 0.708 0.077 -2 0.508
CDK8CDK8 0.708 0.176 1 0.696
BMPR1BBMPR1B 0.708 0.129 1 0.818
CDK7CDK7 0.708 0.165 1 0.711
ERK5ERK5 0.708 0.112 1 0.768
NLKNLK 0.708 0.082 1 0.787
ERK1ERK1 0.708 0.193 1 0.664
RSK2RSK2 0.707 0.067 -3 0.599
PASKPASK 0.707 0.203 -3 0.726
ATRATR 0.706 0.085 1 0.743
PRKXPRKX 0.705 0.094 -3 0.558
CDK17CDK17 0.704 0.145 1 0.630
P38AP38A 0.704 0.208 1 0.722
GRK6GRK6 0.704 0.141 1 0.765
PRKD1PRKD1 0.704 0.091 -3 0.641
LATS1LATS1 0.703 0.134 -3 0.701
JNK2JNK2 0.703 0.145 1 0.664
RIPK3RIPK3 0.702 0.058 3 0.684
RSK4RSK4 0.702 0.078 -3 0.605
PRKD2PRKD2 0.702 0.078 -3 0.584
CLK4CLK4 0.702 0.083 -3 0.598
DYRK1ADYRK1A 0.701 0.166 1 0.727
GRK2GRK2 0.701 0.108 -2 0.510
MAPKAPK2MAPKAPK2 0.700 0.075 -3 0.568
PRPKPRPK 0.700 -0.012 -1 0.819
CAMK1BCAMK1B 0.700 -0.004 -3 0.653
IKKBIKKB 0.700 0.001 -2 0.482
CAMK2BCAMK2B 0.700 0.091 2 0.622
P38DP38D 0.699 0.165 1 0.632
DYRK1BDYRK1B 0.699 0.122 1 0.712
CDK3CDK3 0.699 0.128 1 0.650
PDHK3_TYRPDHK3_TYR 0.699 0.337 4 0.640
P90RSKP90RSK 0.699 0.040 -3 0.603
PKACBPKACB 0.698 0.060 -2 0.502
CDK10CDK10 0.698 0.124 1 0.694
JNK3JNK3 0.698 0.124 1 0.685
PKACGPKACG 0.698 0.033 -2 0.543
DAPK2DAPK2 0.698 0.040 -3 0.666
P38GP38G 0.698 0.134 1 0.624
GRK3GRK3 0.698 0.121 -2 0.480
CDK14CDK14 0.698 0.125 1 0.697
CK1G1CK1G1 0.697 0.172 -3 0.741
PDHK4_TYRPDHK4_TYR 0.697 0.256 2 0.723
CDK5CDK5 0.697 0.123 1 0.729
RAF1RAF1 0.697 -0.015 1 0.700
CAMK2GCAMK2G 0.696 0.014 2 0.643
CAMLCKCAMLCK 0.696 0.018 -2 0.614
NDR1NDR1 0.696 -0.008 -3 0.658
SRPK2SRPK2 0.695 0.047 -3 0.536
DLKDLK 0.695 0.091 1 0.718
IKKAIKKA 0.695 0.049 -2 0.484
MOKMOK 0.695 0.227 1 0.765
MPSK1MPSK1 0.695 0.248 1 0.709
CDK16CDK16 0.695 0.138 1 0.640
MLK1MLK1 0.695 0.010 2 0.620
GRK4GRK4 0.695 0.063 -2 0.587
CDK13CDK13 0.694 0.098 1 0.685
MLK3MLK3 0.694 0.071 2 0.571
DYRK3DYRK3 0.694 0.096 1 0.746
MSK1MSK1 0.693 0.051 -3 0.585
BMPR2BMPR2 0.693 -0.090 -2 0.610
CAMK2DCAMK2D 0.693 0.026 -3 0.631
LATS2LATS2 0.693 0.021 -5 0.470
CLK1CLK1 0.692 0.065 -3 0.556
SRPK3SRPK3 0.692 0.025 -3 0.589
PAK1PAK1 0.691 0.034 -2 0.615
NIKNIK 0.691 -0.039 -3 0.673
ERK2ERK2 0.691 0.118 1 0.693
MAP2K6_TYRMAP2K6_TYR 0.690 0.175 -1 0.831
PRP4PRP4 0.690 0.080 -3 0.647
MLK2MLK2 0.690 0.051 2 0.645
PDHK4PDHK4 0.690 -0.115 1 0.721
HIPK3HIPK3 0.690 0.110 1 0.710
NUAK2NUAK2 0.689 -0.047 -3 0.658
MASTLMASTL 0.689 -0.047 -2 0.581
CDK12CDK12 0.689 0.095 1 0.661
MAPKAPK3MAPKAPK3 0.688 0.012 -3 0.584
TBK1TBK1 0.688 -0.019 1 0.563
PKN2PKN2 0.688 -0.048 -3 0.650
WNK1WNK1 0.688 -0.038 -2 0.645
P70S6KBP70S6KB 0.688 -0.007 -3 0.600
ACVR2BACVR2B 0.688 0.059 -2 0.519
JNK1JNK1 0.688 0.122 1 0.666
PKCDPKCD 0.687 -0.010 2 0.614
TGFBR1TGFBR1 0.687 0.032 -2 0.541
MST4MST4 0.687 -0.030 2 0.682
PDHK1_TYRPDHK1_TYR 0.686 0.164 -1 0.842
ALK4ALK4 0.686 0.017 -2 0.557
PKN3PKN3 0.686 -0.052 -3 0.639
MAP2K4_TYRMAP2K4_TYR 0.686 0.153 -1 0.822
FAM20CFAM20C 0.686 0.029 2 0.476
PKCAPKCA 0.686 0.008 2 0.566
MYLK4MYLK4 0.686 0.000 -2 0.563
RIPK1RIPK1 0.685 -0.052 1 0.694
AURBAURB 0.685 0.016 -2 0.500
MNK1MNK1 0.684 0.017 -2 0.574
BMPR1ABMPR1A 0.684 0.063 1 0.788
BMPR2_TYRBMPR2_TYR 0.684 0.077 -1 0.833
RSK3RSK3 0.684 -0.014 -3 0.578
AMPKA1AMPKA1 0.684 -0.024 -3 0.662
IKKEIKKE 0.684 -0.056 1 0.557
TESK1_TYRTESK1_TYR 0.684 0.075 3 0.760
MSK2MSK2 0.684 -0.004 -3 0.598
TGFBR2TGFBR2 0.684 -0.080 -2 0.533
ACVR2AACVR2A 0.683 0.025 -2 0.515
PKCBPKCB 0.683 -0.009 2 0.564
PKCGPKCG 0.682 -0.018 2 0.577
MLK4MLK4 0.682 0.022 2 0.544
PKCZPKCZ 0.682 0.006 2 0.614
PKG2PKG2 0.682 0.002 -2 0.501
GAKGAK 0.682 0.099 1 0.784
BUB1BUB1 0.682 0.144 -5 0.591
DRAK1DRAK1 0.681 0.032 1 0.767
MNK2MNK2 0.681 0.004 -2 0.572
DSTYKDSTYK 0.681 -0.138 2 0.694
PKRPKR 0.681 -0.025 1 0.725
ANKRD3ANKRD3 0.681 -0.109 1 0.726
NEK6NEK6 0.680 -0.079 -2 0.557
MST3MST3 0.680 0.035 2 0.670
AURAAURA 0.680 0.004 -2 0.490
CK2A1CK2A1 0.680 0.132 1 0.740
ATMATM 0.680 -0.003 1 0.692
VRK2VRK2 0.680 -0.014 1 0.762
GCN2GCN2 0.680 -0.170 2 0.619
CK2A2CK2A2 0.680 0.099 1 0.750
CDK9CDK9 0.679 0.057 1 0.687
PKMYT1_TYRPKMYT1_TYR 0.679 0.003 3 0.753
AMPKA2AMPKA2 0.679 -0.015 -3 0.635
LIMK2_TYRLIMK2_TYR 0.679 0.065 -3 0.673
PAK3PAK3 0.679 -0.026 -2 0.587
PLK1PLK1 0.679 -0.026 -2 0.525
IRE1IRE1 0.679 -0.052 1 0.681
TXKTXK 0.679 0.115 1 0.812
TSSK2TSSK2 0.678 -0.056 -5 0.602
AKT2AKT2 0.678 0.000 -3 0.531
PIM2PIM2 0.678 0.006 -3 0.561
MEK1MEK1 0.678 -0.049 2 0.674
PAK2PAK2 0.678 -0.016 -2 0.594
ALK2ALK2 0.678 0.003 -2 0.543
TLK2TLK2 0.678 0.002 1 0.665
MARK4MARK4 0.678 -0.085 4 0.528
TTBK2TTBK2 0.677 -0.066 2 0.561
SMG1SMG1 0.677 0.002 1 0.694
YANK3YANK3 0.677 0.067 2 0.377
CHAK1CHAK1 0.677 0.007 2 0.664
ULK2ULK2 0.676 -0.188 2 0.613
NEK7NEK7 0.676 -0.159 -3 0.668
PKACAPKACA 0.676 0.017 -2 0.466
TSSK1TSSK1 0.676 -0.039 -3 0.676
DAPK3DAPK3 0.676 0.019 -3 0.629
TNK2TNK2 0.675 0.084 3 0.705
CDK2CDK2 0.675 0.026 1 0.756
HUNKHUNK 0.675 -0.157 2 0.643
DAPK1DAPK1 0.675 0.033 -3 0.625
EPHB4EPHB4 0.675 0.064 -1 0.758
MAP2K7_TYRMAP2K7_TYR 0.675 -0.058 2 0.688
CAMK4CAMK4 0.675 -0.083 -3 0.627
PDHK1PDHK1 0.674 -0.220 1 0.680
PRKD3PRKD3 0.674 -0.022 -3 0.552
MEKK3MEKK3 0.673 -0.040 1 0.678
TAO3TAO3 0.673 0.023 1 0.660
YSK4YSK4 0.673 -0.069 1 0.619
GCKGCK 0.673 0.077 1 0.682
DNAPKDNAPK 0.672 0.024 1 0.589
DCAMKL1DCAMKL1 0.672 -0.021 -3 0.604
CAMK1GCAMK1G 0.671 -0.033 -3 0.569
SGK3SGK3 0.671 -0.027 -3 0.590
PKCHPKCH 0.671 -0.063 2 0.545
QSKQSK 0.671 -0.051 4 0.496
FGRFGR 0.670 -0.002 1 0.760
NEK9NEK9 0.670 -0.158 2 0.645
ULK1ULK1 0.669 -0.166 -3 0.605
PINK1_TYRPINK1_TYR 0.669 -0.118 1 0.724
MEK5MEK5 0.669 -0.108 2 0.649
SMMLCKSMMLCK 0.669 -0.042 -3 0.618
EPHA6EPHA6 0.668 -0.029 -1 0.798
EPHA4EPHA4 0.668 0.023 2 0.646
CK1G2CK1G2 0.668 0.165 -3 0.705
BCKDKBCKDK 0.668 -0.149 -1 0.735
PHKG1PHKG1 0.667 -0.073 -3 0.646
ABL2ABL2 0.667 0.031 -1 0.735
PTK2PTK2 0.667 0.083 -1 0.754
PKCEPKCE 0.667 -0.016 2 0.562
CK1G3CK1G3 0.667 0.174 -3 0.659
WNK3WNK3 0.667 -0.202 1 0.659
LKB1LKB1 0.667 0.060 -3 0.652
MEKK2MEKK2 0.666 -0.075 2 0.616
CDK6CDK6 0.666 0.072 1 0.672
NEK11NEK11 0.666 -0.034 1 0.654
NIM1NIM1 0.666 -0.115 3 0.664
ERK7ERK7 0.666 0.027 2 0.433
FYNFYN 0.666 0.051 -1 0.765
YES1YES1 0.665 -0.006 -1 0.790
NEK5NEK5 0.665 -0.066 1 0.695
LIMK1_TYRLIMK1_TYR 0.665 -0.107 2 0.678
IRE2IRE2 0.665 -0.087 2 0.563
BLKBLK 0.665 0.034 -1 0.774
METMET 0.665 0.020 3 0.716
ROCK2ROCK2 0.664 0.023 -3 0.615
LCKLCK 0.664 0.025 -1 0.772
PLK3PLK3 0.664 -0.052 2 0.625
MARK3MARK3 0.664 -0.065 4 0.469
CDK4CDK4 0.664 0.078 1 0.653
ABL1ABL1 0.663 0.013 -1 0.726
MELKMELK 0.663 -0.096 -3 0.598
SYKSYK 0.663 0.082 -1 0.724
SRMSSRMS 0.663 0.008 1 0.768
NUAK1NUAK1 0.662 -0.091 -3 0.585
QIKQIK 0.662 -0.142 -3 0.631
CSF1RCSF1R 0.662 -0.014 3 0.718
CHK1CHK1 0.662 -0.089 -3 0.603
ZAKZAK 0.662 -0.110 1 0.632
BRSK1BRSK1 0.662 -0.072 -3 0.597
RETRET 0.662 -0.085 1 0.647
HPK1HPK1 0.661 0.004 1 0.661
SIKSIK 0.661 -0.074 -3 0.571
SGK1SGK1 0.661 0.006 -3 0.480
CAMK1DCAMK1D 0.661 -0.018 -3 0.501
TLK1TLK1 0.661 -0.090 -2 0.560
AKT1AKT1 0.660 -0.024 -3 0.548
PINK1PINK1 0.660 -0.120 1 0.761
MAPKAPK5MAPKAPK5 0.660 -0.075 -3 0.537
PAK6PAK6 0.660 -0.044 -2 0.511
DDR1DDR1 0.660 -0.086 4 0.557
ITKITK 0.660 -0.022 -1 0.726
DCAMKL2DCAMKL2 0.660 -0.059 -3 0.598
DDR2DDR2 0.660 0.057 3 0.657
PLK2PLK2 0.660 0.011 -3 0.585
KITKIT 0.659 -0.029 3 0.723
MST1RMST1R 0.659 -0.100 3 0.725
MEKK1MEKK1 0.659 -0.135 1 0.660
INSRRINSRR 0.659 -0.033 3 0.655
FERFER 0.659 -0.070 1 0.774
BMXBMX 0.659 0.010 -1 0.660
PLK4PLK4 0.659 -0.112 2 0.501
IRAK4IRAK4 0.659 -0.085 1 0.666
EPHB1EPHB1 0.658 -0.016 1 0.746
CAMKK2CAMKK2 0.658 -0.037 -2 0.496
KDRKDR 0.658 -0.054 3 0.696
TYRO3TYRO3 0.658 -0.112 3 0.693
PDK1PDK1 0.658 -0.063 1 0.649
AKT3AKT3 0.658 -0.004 -3 0.500
MRCKAMRCKA 0.657 -0.002 -3 0.566
PBKPBK 0.657 0.031 1 0.706
SLKSLK 0.657 -0.008 -2 0.507
MST2MST2 0.657 -0.052 1 0.672
FLT1FLT1 0.657 -0.013 -1 0.764
STK33STK33 0.657 -0.041 2 0.527
EPHB2EPHB2 0.657 -0.010 -1 0.730
NEK2NEK2 0.657 -0.146 2 0.645
ROS1ROS1 0.656 -0.091 3 0.664
DMPK1DMPK1 0.656 0.006 -3 0.581
PERKPERK 0.656 -0.158 -2 0.548
MAP3K15MAP3K15 0.656 -0.015 1 0.606
HCKHCK 0.656 -0.052 -1 0.762
PKCIPKCI 0.656 -0.067 2 0.580
KHS2KHS2 0.656 0.013 1 0.651
BRAFBRAF 0.656 -0.142 -4 0.662
EPHB3EPHB3 0.656 -0.031 -1 0.736
LRRK2LRRK2 0.656 -0.061 2 0.674
BRSK2BRSK2 0.655 -0.107 -3 0.602
SSTKSSTK 0.655 -0.076 4 0.477
P70S6KP70S6K 0.655 -0.049 -3 0.520
MERTKMERTK 0.655 -0.023 3 0.703
JAK3JAK3 0.655 -0.083 1 0.637
EPHA7EPHA7 0.655 -0.007 2 0.644
PAK4PAK4 0.655 -0.016 -2 0.520
WNK4WNK4 0.655 -0.127 -2 0.630
EEF2KEEF2K 0.654 -0.023 3 0.692
MARK2MARK2 0.654 -0.116 4 0.436
SBKSBK 0.654 0.008 -3 0.423
JAK2JAK2 0.654 -0.096 1 0.627
TNIKTNIK 0.654 -0.024 3 0.749
PTK2BPTK2B 0.654 0.009 -1 0.696
PKCTPKCT 0.654 -0.090 2 0.555
TAK1TAK1 0.653 -0.059 1 0.671
YANK2YANK2 0.653 0.062 2 0.381
NEK8NEK8 0.652 -0.139 2 0.638
KHS1KHS1 0.652 0.004 1 0.623
EPHA3EPHA3 0.652 -0.038 2 0.619
TNK1TNK1 0.652 -0.043 3 0.690
MRCKBMRCKB 0.652 -0.025 -3 0.551
MINKMINK 0.652 -0.058 1 0.635
FGFR2FGFR2 0.652 -0.102 3 0.719
PAK5PAK5 0.652 -0.039 -2 0.500
CHK2CHK2 0.651 -0.036 -3 0.473
HASPINHASPIN 0.651 0.030 -1 0.725
CAMKK1CAMKK1 0.650 -0.138 -2 0.482
TAO2TAO2 0.650 -0.115 2 0.671
TTKTTK 0.650 -0.013 -2 0.566
HGKHGK 0.650 -0.056 3 0.751
SRCSRC 0.650 -0.012 -1 0.751
MARK1MARK1 0.650 -0.122 4 0.472
ZAP70ZAP70 0.649 0.048 -1 0.669
VRK1VRK1 0.649 -0.081 2 0.654
TYK2TYK2 0.649 -0.194 1 0.632
CRIKCRIK 0.649 0.008 -3 0.551
MST1MST1 0.648 -0.048 1 0.640
EPHA8EPHA8 0.648 -0.011 -1 0.736
EPHA5EPHA5 0.648 -0.016 2 0.626
SNRKSNRK 0.648 -0.192 2 0.543
OSR1OSR1 0.648 -0.025 2 0.640
TTBK1TTBK1 0.648 -0.106 2 0.508
CAMK1ACAMK1A 0.648 -0.027 -3 0.486
ALPHAK3ALPHAK3 0.648 0.057 -1 0.732
MATKMATK 0.647 -0.045 -1 0.683
AXLAXL 0.647 -0.079 3 0.698
MEKK6MEKK6 0.647 -0.122 1 0.649
WEE1_TYRWEE1_TYR 0.647 -0.079 -1 0.705
HRIHRI 0.647 -0.219 -2 0.563
FGFR3FGFR3 0.646 -0.080 3 0.697
JAK1JAK1 0.646 -0.041 1 0.569
LYNLYN 0.645 -0.061 3 0.649
LOKLOK 0.645 -0.073 -2 0.527
PDGFRBPDGFRB 0.645 -0.148 3 0.709
ERBB4ERBB4 0.645 0.006 1 0.616
NEK4NEK4 0.645 -0.128 1 0.636
TECTEC 0.645 -0.081 -1 0.656
NEK1NEK1 0.644 -0.092 1 0.652
ERBB2ERBB2 0.644 -0.092 1 0.626
ROCK1ROCK1 0.643 -0.026 -3 0.567
TNNI3K_TYRTNNI3K_TYR 0.643 -0.107 1 0.667
NTRK1NTRK1 0.642 -0.109 -1 0.741
FRKFRK 0.641 -0.080 -1 0.757
TEKTEK 0.641 -0.173 3 0.652
FGFR4FGFR4 0.641 -0.029 -1 0.692
NEK10_TYRNEK10_TYR 0.641 -0.080 1 0.511
FLT3FLT3 0.641 -0.175 3 0.706
NTRK3NTRK3 0.640 -0.056 -1 0.696
EPHA1EPHA1 0.640 -0.092 3 0.702
CSKCSK 0.640 -0.030 2 0.636
BIKEBIKE 0.640 0.011 1 0.698
ALKALK 0.640 -0.105 3 0.621
EGFREGFR 0.640 -0.045 1 0.548
LTKLTK 0.639 -0.111 3 0.655
FGFR1FGFR1 0.638 -0.163 3 0.674
PTK6PTK6 0.638 -0.118 -1 0.653
EPHA2EPHA2 0.638 -0.026 -1 0.695
INSRINSR 0.638 -0.104 3 0.638
BTKBTK 0.637 -0.163 -1 0.687
FLT4FLT4 0.637 -0.142 3 0.689
PKN1PKN1 0.636 -0.091 -3 0.531
PDGFRAPDGFRA 0.636 -0.172 3 0.708
PHKG2PHKG2 0.634 -0.150 -3 0.585
YSK1YSK1 0.633 -0.131 2 0.625
IRAK1IRAK1 0.633 -0.256 -1 0.710
MYO3BMYO3B 0.633 -0.069 2 0.658
AAK1AAK1 0.631 0.041 1 0.621
ASK1ASK1 0.631 -0.073 1 0.592
NTRK2NTRK2 0.630 -0.168 3 0.676
IGF1RIGF1R 0.628 -0.081 3 0.585
MEK2MEK2 0.628 -0.215 2 0.638
MYO3AMYO3A 0.628 -0.096 1 0.642
PKG1PKG1 0.625 -0.077 -2 0.432
FESFES 0.624 -0.053 -1 0.638
RIPK2RIPK2 0.623 -0.226 1 0.578
TAO1TAO1 0.618 -0.120 1 0.557
STLK3STLK3 0.614 -0.145 1 0.592
MUSKMUSK 0.613 -0.142 1 0.538
NEK3NEK3 0.609 -0.251 1 0.593