Motif 182 (n=96)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
H0Y626 | None | S27 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
O14828 | SCAMP3 | S72 | ochoa | Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
O15417 | TNRC18 | S2375 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
O75161 | NPHP4 | S481 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
O75175 | CNOT3 | S513 | ochoa | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
O75381 | PEX14 | S271 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
O95361 | TRIM16 | S27 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
P10636 | MAPT | S420 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
P10636 | MAPT | S508 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
P10636 | MAPT | S515 | ochoa|psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
P11137 | MAP2 | S1598 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
P13807 | GYS1 | Y634 | ochoa|psp | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
P17302 | GJA1 | Y265 | psp | Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}. |
P24928 | POLR2A | Y1615 | psp | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1839 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1846 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1853 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1860 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1867 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1874 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1881 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1888 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1895 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1902 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1909 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1916 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1923 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | Y1930 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P24928 | POLR2A | T1933 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
P50548 | ERF | S150 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
P54259 | ATN1 | S174 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
P57682 | KLF3 | Y107 | ochoa | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
P85037 | FOXK1 | S239 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
P85037 | FOXK1 | S249 | ochoa | Forkhead box protein K1 (Myocyte nuclear factor) (MNF) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK1-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:17670796, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164, ECO:0000269|PubMed:30664650}. |
Q05193 | DNM1 | S774 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
Q05193 | DNM1 | S795 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
Q07889 | SOS1 | S1203 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
Q07912 | TNK2 | S774 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
Q13112 | CHAF1B | S513 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
Q13136 | PPFIA1 | S697 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
Q14207 | NPAT | S1302 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
Q15691 | MAPRE1 | S165 | ochoa | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}. |
Q16204 | CCDC6 | S384 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
Q3KQU3 | MAP7D1 | S41 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q3KQU3 | MAP7D1 | S112 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q3KQU3 | MAP7D1 | S479 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q4VCS5 | AMOT | S328 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
Q5T5P2 | KIAA1217 | S322 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
Q68CZ2 | TNS3 | S873 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
Q6F5E8 | CARMIL2 | T1412 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
Q6IQ23 | PLEKHA7 | S867 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
Q6IQ23 | PLEKHA7 | Y888 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
Q6P0Q8 | MAST2 | S1340 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
Q6PKG0 | LARP1 | Y777 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
Q70E73 | RAPH1 | S845 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q70E73 | RAPH1 | S1094 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q7Z5L9 | IRF2BP2 | S395 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
Q7Z5L9 | IRF2BP2 | S409 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
Q86WR7 | PROSER2 | S166 | ochoa | Proline and serine-rich protein 2 | None |
Q86X29 | LSR | Y328 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
Q8IYB3 | SRRM1 | S773 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q8IZP0 | ABI1 | Y198 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
Q8N3V7 | SYNPO | Y789 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8TEY7 | USP33 | S443 | ochoa | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1) | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}. |
Q8WUF5 | PPP1R13L | S73 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
Q8WUF5 | PPP1R13L | Y109 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
Q8WWM7 | ATXN2L | S434 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
Q8WWM7 | ATXN2L | S630 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
Q8WXF1 | PSPC1 | S473 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
Q93052 | LPP | S155 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
Q96JH7 | VCPIP1 | S757 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
Q96JM3 | CHAMP1 | S372 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96JM3 | CHAMP1 | S382 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96ST3 | SIN3A | S263 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
Q96ST3 | SIN3A | T266 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
Q9BQI5 | SGIP1 | S482 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
Q9BUL9 | RPP25 | Y151 | ochoa | Ribonuclease P protein subunit p25 (RNase P protein subunit p25) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:16723659, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}. |
Q9C0B0 | UNK | S374 | ochoa | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9H4L4 | SENP3 | S54 | ochoa | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
Q9H5H4 | ZNF768 | S107 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
Q9H5H4 | ZNF768 | Y121 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
Q9H792 | PEAK1 | S819 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9H792 | PEAK1 | S864 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9HDC5 | JPH1 | S465 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
Q9NYB9 | ABI2 | Y198 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
Q9P0K7 | RAI14 | S296 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
Q9P1Y5 | CAMSAP3 | S347 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9UGJ0 | PRKAG2 | S90 | ochoa | 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. |
Q9UGP4 | LIMD1 | S214 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
Q9UJM3 | ERRFI1 | S276 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
Q9UMS6 | SYNPO2 | S770 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UMS6 | SYNPO2 | S777 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UQ35 | SRRM2 | S387 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9UQ35 | SRRM2 | S404 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y4F5 | CEP170B | S721 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
Q9Y4F5 | CEP170B | S875 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 0.016507 | 1.782 |
R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 0.016507 | 1.782 |
R-HSA-196025 | Formation of annular gap junctions | 0.001002 | 2.999 |
R-HSA-190873 | Gap junction degradation | 0.001189 | 2.925 |
R-HSA-191650 | Regulation of gap junction activity | 0.024660 | 1.608 |
R-HSA-112412 | SOS-mediated signalling | 0.040766 | 1.390 |
R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.044751 | 1.349 |
R-HSA-179812 | GRB2 events in EGFR signaling | 0.064435 | 1.191 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.008999 | 2.046 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.083719 | 1.077 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.087528 | 1.058 |
R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.095101 | 1.022 |
R-HSA-6803529 | FGFR2 alternative splicing | 0.110060 | 0.958 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.113762 | 0.944 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.113762 | 0.944 |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.128417 | 0.891 |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.128417 | 0.891 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.132044 | 0.879 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.132044 | 0.879 |
R-HSA-167287 | HIV elongation arrest and recovery | 0.132044 | 0.879 |
R-HSA-167290 | Pausing and recovery of HIV elongation | 0.132044 | 0.879 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.177856 | 0.750 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.184689 | 0.734 |
R-HSA-167161 | HIV Transcription Initiation | 0.184689 | 0.734 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.184689 | 0.734 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.191467 | 0.718 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.198188 | 0.703 |
R-HSA-72172 | mRNA Splicing | 0.066942 | 1.174 |
R-HSA-167169 | HIV Transcription Elongation | 0.177856 | 0.750 |
R-HSA-72086 | mRNA Capping | 0.135655 | 0.868 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.059403 | 1.226 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.064276 | 1.192 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.177856 | 0.750 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.174418 | 0.758 |
R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.048720 | 1.312 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.139252 | 0.856 |
R-HSA-157858 | Gap junction trafficking and regulation | 0.023794 | 1.624 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.128608 | 0.891 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 0.091322 | 1.039 |
R-HSA-190828 | Gap junction trafficking | 0.020067 | 1.698 |
R-HSA-2424491 | DAP12 signaling | 0.139252 | 0.856 |
R-HSA-8851805 | MET activates RAS signaling | 0.064435 | 1.191 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.177856 | 0.750 |
R-HSA-74749 | Signal attenuation | 0.052673 | 1.278 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.181280 | 0.742 |
R-HSA-190861 | Gap junction assembly | 0.157016 | 0.804 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.029811 | 1.526 |
R-HSA-190827 | Transport of connexins along the secretory pathway | 0.012406 | 1.906 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.020592 | 1.686 |
R-HSA-8875513 | MET interacts with TNS proteins | 0.020592 | 1.686 |
R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.052673 | 1.278 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.056610 | 1.247 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.060530 | 1.218 |
R-HSA-428540 | Activation of RAC1 | 0.060530 | 1.218 |
R-HSA-180336 | SHC1 events in EGFR signaling | 0.076053 | 1.119 |
R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.079894 | 1.097 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.079894 | 1.097 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.083719 | 1.077 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.091322 | 1.039 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.095101 | 1.022 |
R-HSA-3322077 | Glycogen synthesis | 0.098864 | 1.005 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.102611 | 0.989 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.106343 | 0.973 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.117448 | 0.930 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.128417 | 0.891 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.043130 | 1.365 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.044472 | 1.352 |
R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.064435 | 1.191 |
R-HSA-3229121 | Glycogen storage diseases | 0.087528 | 1.058 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.110060 | 0.958 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.040233 | 1.395 |
R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.076053 | 1.119 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.095101 | 1.022 |
R-HSA-190704 | Oligomerization of connexins into connexons | 0.012406 | 1.906 |
R-HSA-8964046 | VLDL clearance | 0.040766 | 1.390 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.052673 | 1.278 |
R-HSA-177504 | Retrograde neurotrophin signalling | 0.072196 | 1.141 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.102611 | 0.989 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.117448 | 0.930 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.139252 | 0.856 |
R-HSA-2172127 | DAP12 interactions | 0.194834 | 0.710 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.117448 | 0.930 |
R-HSA-8982491 | Glycogen metabolism | 0.177856 | 0.750 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.064435 | 1.191 |
R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.076053 | 1.119 |
R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.076053 | 1.119 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.091322 | 1.039 |
R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.024660 | 1.608 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.052673 | 1.278 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.064435 | 1.191 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.076053 | 1.119 |
R-HSA-429947 | Deadenylation of mRNA | 0.117448 | 0.930 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.124776 | 0.904 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.052269 | 1.282 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.177856 | 0.750 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.140557 | 0.852 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.135655 | 0.868 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.139252 | 0.856 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.087528 | 1.058 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.087528 | 1.058 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.095101 | 1.022 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.106343 | 0.973 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.110060 | 0.958 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.121120 | 0.917 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.132044 | 0.879 |
R-HSA-9664417 | Leishmania phagocytosis | 0.139139 | 0.857 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.139139 | 0.857 |
R-HSA-9664407 | Parasite infection | 0.139139 | 0.857 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.157016 | 0.804 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.162181 | 0.790 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.160525 | 0.794 |
R-HSA-9842663 | Signaling by LTK | 0.002091 | 2.680 |
R-HSA-9613354 | Lipophagy | 0.048720 | 1.312 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.064435 | 1.191 |
R-HSA-9005895 | Pervasive developmental disorders | 0.064435 | 1.191 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.064435 | 1.191 |
R-HSA-167044 | Signalling to RAS | 0.102611 | 0.989 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.055472 | 1.256 |
R-HSA-8953854 | Metabolism of RNA | 0.064781 | 1.189 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.124776 | 0.904 |
R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.110060 | 0.958 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.102611 | 0.989 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.102611 | 0.989 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.135655 | 0.868 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.139252 | 0.856 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.160525 | 0.794 |
R-HSA-5654738 | Signaling by FGFR2 | 0.052269 | 1.282 |
R-HSA-165159 | MTOR signalling | 0.188085 | 0.726 |
R-HSA-199991 | Membrane Trafficking | 0.145716 | 0.836 |
R-HSA-2028269 | Signaling by Hippo | 0.003890 | 2.410 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.079894 | 1.097 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.083719 | 1.077 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.106343 | 0.973 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.113762 | 0.944 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.160525 | 0.794 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.124776 | 0.904 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.157806 | 0.802 |
R-HSA-210993 | Tie2 Signaling | 0.091322 | 1.039 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.191859 | 0.717 |
R-HSA-190236 | Signaling by FGFR | 0.075913 | 1.120 |
R-HSA-6806834 | Signaling by MET | 0.052269 | 1.282 |
R-HSA-72312 | rRNA processing | 0.087980 | 1.056 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 0.072196 | 1.141 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.102611 | 0.989 |
R-HSA-1433559 | Regulation of KIT signaling | 0.072196 | 1.141 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.121120 | 0.917 |
R-HSA-186763 | Downstream signal transduction | 0.142834 | 0.845 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.124776 | 0.904 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.024571 | 1.610 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.106343 | 0.973 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.128417 | 0.891 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.168513 | 0.773 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.048720 | 1.312 |
R-HSA-9762292 | Regulation of CDH11 function | 0.052673 | 1.278 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.068323 | 1.165 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.106343 | 0.973 |
R-HSA-200425 | Carnitine shuttle | 0.113762 | 0.944 |
R-HSA-5654743 | Signaling by FGFR4 | 0.191467 | 0.718 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 0.128417 | 0.891 |
R-HSA-201556 | Signaling by ALK | 0.174418 | 0.758 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.004750 | 2.323 |
R-HSA-5654741 | Signaling by FGFR3 | 0.198188 | 0.703 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.046104 | 1.336 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.117448 | 0.930 |
R-HSA-8853659 | RET signaling | 0.164020 | 0.785 |
R-HSA-8875878 | MET promotes cell motility | 0.170966 | 0.767 |
R-HSA-376176 | Signaling by ROBO receptors | 0.065540 | 1.183 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.135655 | 0.868 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.171567 | 0.766 |
R-HSA-9669938 | Signaling by KIT in disease | 0.110060 | 0.958 |
R-HSA-9682385 | FLT3 signaling in disease | 0.164020 | 0.785 |
R-HSA-438064 | Post NMDA receptor activation events | 0.060915 | 1.215 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.191467 | 0.718 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.110060 | 0.958 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.149954 | 0.824 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.167500 | 0.776 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.121120 | 0.917 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.083193 | 1.080 |
R-HSA-5688426 | Deubiquitination | 0.107093 | 0.970 |
R-HSA-187687 | Signalling to ERKs | 0.160525 | 0.794 |
R-HSA-8983432 | Interleukin-15 signaling | 0.064435 | 1.191 |
R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.184689 | 0.734 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.184689 | 0.734 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 0.164020 | 0.785 |
R-HSA-8964043 | Plasma lipoprotein clearance | 0.174418 | 0.758 |
R-HSA-166520 | Signaling by NTRKs | 0.152011 | 0.818 |
R-HSA-8964038 | LDL clearance | 0.110060 | 0.958 |
R-HSA-9607240 | FLT3 Signaling | 0.181280 | 0.742 |
R-HSA-162582 | Signal Transduction | 0.187905 | 0.726 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.080742 | 1.093 |
R-HSA-354192 | Integrin signaling | 0.149954 | 0.824 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.198188 | 0.703 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.135655 | 0.868 |
R-HSA-451927 | Interleukin-2 family signaling | 0.177856 | 0.750 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.144119 | 0.841 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.149954 | 0.824 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.119654 | 0.922 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.146401 | 0.834 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.188085 | 0.726 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.169521 | 0.771 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.100952 | 0.996 |
R-HSA-194138 | Signaling by VEGF | 0.115575 | 0.937 |
R-HSA-168255 | Influenza Infection | 0.199394 | 0.700 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.201529 | 0.696 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.201529 | 0.696 |
R-HSA-75153 | Apoptotic execution phase | 0.201529 | 0.696 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.204855 | 0.689 |
R-HSA-437239 | Recycling pathway of L1 | 0.204855 | 0.689 |
R-HSA-422475 | Axon guidance | 0.209487 | 0.679 |
R-HSA-5617833 | Cilium Assembly | 0.216094 | 0.665 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.218025 | 0.661 |
R-HSA-72187 | mRNA 3'-end processing | 0.221284 | 0.655 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.221284 | 0.655 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.221284 | 0.655 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.221284 | 0.655 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.224530 | 0.649 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.234186 | 0.630 |
R-HSA-193648 | NRAGE signals death through JNK | 0.234186 | 0.630 |
R-HSA-177929 | Signaling by EGFR | 0.234186 | 0.630 |
R-HSA-5654736 | Signaling by FGFR1 | 0.234186 | 0.630 |
R-HSA-112399 | IRS-mediated signalling | 0.237379 | 0.625 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.237379 | 0.625 |
R-HSA-6782135 | Dual incision in TC-NER | 0.240558 | 0.619 |
R-HSA-9675108 | Nervous system development | 0.242274 | 0.616 |
R-HSA-9033241 | Peroxisomal protein import | 0.243724 | 0.613 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.243724 | 0.613 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.246878 | 0.608 |
R-HSA-1227986 | Signaling by ERBB2 | 0.246878 | 0.608 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.250018 | 0.602 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.250018 | 0.602 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.250018 | 0.602 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.251374 | 0.600 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.253146 | 0.597 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.253146 | 0.597 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.253146 | 0.597 |
R-HSA-186797 | Signaling by PDGF | 0.253146 | 0.597 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.256260 | 0.591 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.256260 | 0.591 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.259362 | 0.586 |
R-HSA-2428924 | IGF1R signaling cascade | 0.259362 | 0.586 |
R-HSA-5653656 | Vesicle-mediated transport | 0.262193 | 0.581 |
R-HSA-1234174 | Cellular response to hypoxia | 0.262451 | 0.581 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.262451 | 0.581 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.265527 | 0.576 |
R-HSA-167172 | Transcription of the HIV genome | 0.271642 | 0.566 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.272959 | 0.564 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.276043 | 0.559 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.283722 | 0.547 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.286711 | 0.543 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.286711 | 0.543 |
R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.286711 | 0.543 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.286711 | 0.543 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.286711 | 0.543 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.289688 | 0.538 |
R-HSA-1236394 | Signaling by ERBB4 | 0.289688 | 0.538 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.292652 | 0.534 |
R-HSA-380287 | Centrosome maturation | 0.292652 | 0.534 |
R-HSA-8852135 | Protein ubiquitination | 0.292652 | 0.534 |
R-HSA-5689603 | UCH proteinases | 0.295604 | 0.529 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.301472 | 0.521 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.301472 | 0.521 |
R-HSA-9833482 | PKR-mediated signaling | 0.307292 | 0.512 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.313064 | 0.504 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.315933 | 0.500 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.318789 | 0.496 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.321634 | 0.493 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.324467 | 0.489 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.324467 | 0.489 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.324467 | 0.489 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.327288 | 0.485 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.327288 | 0.485 |
R-HSA-112316 | Neuronal System | 0.332809 | 0.478 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.332896 | 0.478 |
R-HSA-156902 | Peptide chain elongation | 0.332896 | 0.478 |
R-HSA-9663891 | Selective autophagy | 0.332896 | 0.478 |
R-HSA-112310 | Neurotransmitter release cycle | 0.338458 | 0.470 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.341222 | 0.467 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.341222 | 0.467 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.343975 | 0.463 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.346716 | 0.460 |
R-HSA-74752 | Signaling by Insulin receptor | 0.346716 | 0.460 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.346716 | 0.460 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.346716 | 0.460 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.349445 | 0.457 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.354871 | 0.450 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.357062 | 0.447 |
R-HSA-9658195 | Leishmania infection | 0.357062 | 0.447 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.357568 | 0.447 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.357568 | 0.447 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.357568 | 0.447 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.360253 | 0.443 |
R-HSA-157579 | Telomere Maintenance | 0.362927 | 0.440 |
R-HSA-9614085 | FOXO-mediated transcription | 0.368242 | 0.434 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.368242 | 0.434 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.370883 | 0.431 |
R-HSA-2408557 | Selenocysteine synthesis | 0.373514 | 0.428 |
R-HSA-192823 | Viral mRNA Translation | 0.378742 | 0.422 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.381340 | 0.419 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.383927 | 0.416 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.383927 | 0.416 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.386504 | 0.413 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.391625 | 0.407 |
R-HSA-211000 | Gene Silencing by RNA | 0.391625 | 0.407 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.394170 | 0.404 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.394170 | 0.404 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.396704 | 0.402 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.404245 | 0.393 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.404245 | 0.393 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.404245 | 0.393 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.409220 | 0.388 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.414155 | 0.383 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.416607 | 0.380 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.419049 | 0.378 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.419049 | 0.378 |
R-HSA-373760 | L1CAM interactions | 0.419049 | 0.378 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.419067 | 0.378 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.421480 | 0.375 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.431108 | 0.365 |
R-HSA-73886 | Chromosome Maintenance | 0.431108 | 0.365 |
R-HSA-9679506 | SARS-CoV Infections | 0.431275 | 0.365 |
R-HSA-2132295 | MHC class II antigen presentation | 0.435862 | 0.361 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.435862 | 0.361 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.455971 | 0.341 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.472514 | 0.326 |
R-HSA-163685 | Integration of energy metabolism | 0.472514 | 0.326 |
R-HSA-9948299 | Ribosome-associated quality control | 0.476927 | 0.322 |
R-HSA-6807070 | PTEN Regulation | 0.479120 | 0.320 |
R-HSA-1632852 | Macroautophagy | 0.483479 | 0.316 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.487802 | 0.312 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.487802 | 0.312 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.500558 | 0.301 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.504740 | 0.297 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.504740 | 0.297 |
R-HSA-9609507 | Protein localization | 0.510948 | 0.292 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.513001 | 0.290 |
R-HSA-73887 | Death Receptor Signaling | 0.513001 | 0.290 |
R-HSA-9612973 | Autophagy | 0.517080 | 0.286 |
R-HSA-162587 | HIV Life Cycle | 0.519107 | 0.285 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.519107 | 0.285 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.521126 | 0.283 |
R-HSA-9711097 | Cellular response to starvation | 0.521126 | 0.283 |
R-HSA-9824446 | Viral Infection Pathways | 0.524713 | 0.280 |
R-HSA-109581 | Apoptosis | 0.529117 | 0.276 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.533064 | 0.273 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.533064 | 0.273 |
R-HSA-8953897 | Cellular responses to stimuli | 0.538846 | 0.269 |
R-HSA-72306 | tRNA processing | 0.546621 | 0.262 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.550423 | 0.259 |
R-HSA-5689880 | Ub-specific processing proteases | 0.552312 | 0.258 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.556066 | 0.255 |
R-HSA-2559583 | Cellular Senescence | 0.565318 | 0.248 |
R-HSA-69275 | G2/M Transition | 0.576170 | 0.239 |
R-HSA-5663205 | Infectious disease | 0.577778 | 0.238 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.579705 | 0.237 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.579727 | 0.237 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.585009 | 0.233 |
R-HSA-68877 | Mitotic Prometaphase | 0.588493 | 0.230 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.593666 | 0.226 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.600463 | 0.222 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.605488 | 0.218 |
R-HSA-5357801 | Programmed Cell Death | 0.610450 | 0.214 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.623384 | 0.205 |
R-HSA-68882 | Mitotic Anaphase | 0.628124 | 0.202 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.629691 | 0.201 |
R-HSA-418990 | Adherens junctions interactions | 0.631252 | 0.200 |
R-HSA-2262752 | Cellular responses to stress | 0.634860 | 0.197 |
R-HSA-162906 | HIV Infection | 0.645008 | 0.190 |
R-HSA-212436 | Generic Transcription Pathway | 0.648927 | 0.188 |
R-HSA-1280218 | Adaptive Immune System | 0.655900 | 0.183 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.657705 | 0.182 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.659700 | 0.181 |
R-HSA-8939211 | ESR-mediated signaling | 0.659700 | 0.181 |
R-HSA-421270 | Cell-cell junction organization | 0.679268 | 0.168 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.685984 | 0.164 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.688632 | 0.162 |
R-HSA-416476 | G alpha (q) signalling events | 0.696443 | 0.157 |
R-HSA-9711123 | Cellular response to chemical stress | 0.701544 | 0.154 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.709036 | 0.149 |
R-HSA-446728 | Cell junction organization | 0.713927 | 0.146 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.718738 | 0.143 |
R-HSA-1266738 | Developmental Biology | 0.725718 | 0.139 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.726965 | 0.138 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.733828 | 0.134 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.734956 | 0.134 |
R-HSA-74160 | Gene expression (Transcription) | 0.736689 | 0.133 |
R-HSA-1500931 | Cell-Cell communication | 0.756537 | 0.121 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.782023 | 0.107 |
R-HSA-5683057 | MAPK family signaling cascades | 0.786614 | 0.104 |
R-HSA-73894 | DNA Repair | 0.798109 | 0.098 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.800673 | 0.097 |
R-HSA-1640170 | Cell Cycle | 0.812574 | 0.090 |
R-HSA-68886 | M Phase | 0.816970 | 0.088 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.817750 | 0.087 |
R-HSA-913531 | Interferon Signaling | 0.817750 | 0.087 |
R-HSA-168249 | Innate Immune System | 0.823367 | 0.084 |
R-HSA-8978868 | Fatty acid metabolism | 0.835506 | 0.078 |
R-HSA-597592 | Post-translational protein modification | 0.840947 | 0.075 |
R-HSA-5668914 | Diseases of metabolism | 0.848992 | 0.071 |
R-HSA-72766 | Translation | 0.850279 | 0.070 |
R-HSA-109582 | Hemostasis | 0.854305 | 0.068 |
R-HSA-1643685 | Disease | 0.861715 | 0.065 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.866060 | 0.062 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.916921 | 0.038 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.933655 | 0.030 |
R-HSA-449147 | Signaling by Interleukins | 0.935637 | 0.029 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.947414 | 0.023 |
R-HSA-392499 | Metabolism of proteins | 0.950830 | 0.022 |
R-HSA-168256 | Immune System | 0.958478 | 0.018 |
R-HSA-388396 | GPCR downstream signalling | 0.966366 | 0.015 |
R-HSA-372790 | Signaling by GPCR | 0.976634 | 0.010 |
R-HSA-382551 | Transport of small molecules | 0.986491 | 0.006 |
R-HSA-556833 | Metabolism of lipids | 0.989134 | 0.005 |
R-HSA-1430728 | Metabolism | 0.999972 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.747 | 0.269 | 1 | 0.796 |
GSK3A |
0.743 | 0.386 | 4 | 0.768 |
GRK1 |
0.737 | 0.261 | -2 | 0.591 |
HIPK4 |
0.735 | 0.283 | 1 | 0.768 |
MAK |
0.730 | 0.351 | -2 | 0.889 |
HIPK2 |
0.729 | 0.223 | 1 | 0.679 |
KIS |
0.729 | 0.173 | 1 | 0.705 |
COT |
0.729 | 0.154 | 2 | 0.694 |
GSK3B |
0.728 | 0.344 | 4 | 0.769 |
MOS |
0.726 | 0.239 | 1 | 0.800 |
CDC7 |
0.725 | 0.224 | 1 | 0.803 |
GRK7 |
0.723 | 0.229 | 1 | 0.697 |
PIM3 |
0.723 | 0.131 | -3 | 0.687 |
ICK |
0.723 | 0.279 | -3 | 0.667 |
SKMLCK |
0.722 | 0.164 | -2 | 0.643 |
CLK2 |
0.721 | 0.162 | -3 | 0.594 |
CK1E |
0.721 | 0.233 | -3 | 0.762 |
CK1D |
0.720 | 0.241 | -3 | 0.738 |
DYRK2 |
0.720 | 0.170 | 1 | 0.741 |
CDK1 |
0.719 | 0.175 | 1 | 0.706 |
CDK18 |
0.719 | 0.189 | 1 | 0.667 |
CDKL5 |
0.717 | 0.193 | -3 | 0.622 |
CK1A2 |
0.716 | 0.232 | -3 | 0.736 |
NDR2 |
0.716 | 0.104 | -3 | 0.696 |
SRPK1 |
0.715 | 0.093 | -3 | 0.607 |
CDKL1 |
0.714 | 0.152 | -3 | 0.633 |
CHAK2 |
0.714 | 0.203 | -1 | 0.884 |
P38B |
0.713 | 0.232 | 1 | 0.675 |
HIPK1 |
0.713 | 0.161 | 1 | 0.748 |
GRK5 |
0.712 | 0.164 | -3 | 0.736 |
CK1A |
0.712 | 0.261 | -3 | 0.690 |
PIM1 |
0.711 | 0.092 | -3 | 0.637 |
MTOR |
0.711 | 0.150 | 1 | 0.676 |
DYRK4 |
0.710 | 0.155 | 1 | 0.688 |
CDK19 |
0.709 | 0.188 | 1 | 0.672 |
CAMK2A |
0.708 | 0.136 | 2 | 0.640 |
AURC |
0.708 | 0.077 | -2 | 0.508 |
CDK8 |
0.708 | 0.176 | 1 | 0.696 |
BMPR1B |
0.708 | 0.129 | 1 | 0.818 |
CDK7 |
0.708 | 0.165 | 1 | 0.711 |
ERK5 |
0.708 | 0.112 | 1 | 0.768 |
NLK |
0.708 | 0.082 | 1 | 0.787 |
ERK1 |
0.708 | 0.193 | 1 | 0.664 |
RSK2 |
0.707 | 0.067 | -3 | 0.599 |
PASK |
0.707 | 0.203 | -3 | 0.726 |
ATR |
0.706 | 0.085 | 1 | 0.743 |
PRKX |
0.705 | 0.094 | -3 | 0.558 |
CDK17 |
0.704 | 0.145 | 1 | 0.630 |
P38A |
0.704 | 0.208 | 1 | 0.722 |
GRK6 |
0.704 | 0.141 | 1 | 0.765 |
PRKD1 |
0.704 | 0.091 | -3 | 0.641 |
LATS1 |
0.703 | 0.134 | -3 | 0.701 |
JNK2 |
0.703 | 0.145 | 1 | 0.664 |
RIPK3 |
0.702 | 0.058 | 3 | 0.684 |
RSK4 |
0.702 | 0.078 | -3 | 0.605 |
PRKD2 |
0.702 | 0.078 | -3 | 0.584 |
CLK4 |
0.702 | 0.083 | -3 | 0.598 |
DYRK1A |
0.701 | 0.166 | 1 | 0.727 |
GRK2 |
0.701 | 0.108 | -2 | 0.510 |
MAPKAPK2 |
0.700 | 0.075 | -3 | 0.568 |
PRPK |
0.700 | -0.012 | -1 | 0.819 |
CAMK1B |
0.700 | -0.004 | -3 | 0.653 |
IKKB |
0.700 | 0.001 | -2 | 0.482 |
CAMK2B |
0.700 | 0.091 | 2 | 0.622 |
P38D |
0.699 | 0.165 | 1 | 0.632 |
DYRK1B |
0.699 | 0.122 | 1 | 0.712 |
CDK3 |
0.699 | 0.128 | 1 | 0.650 |
PDHK3_TYR |
0.699 | 0.337 | 4 | 0.640 |
P90RSK |
0.699 | 0.040 | -3 | 0.603 |
PKACB |
0.698 | 0.060 | -2 | 0.502 |
CDK10 |
0.698 | 0.124 | 1 | 0.694 |
JNK3 |
0.698 | 0.124 | 1 | 0.685 |
PKACG |
0.698 | 0.033 | -2 | 0.543 |
DAPK2 |
0.698 | 0.040 | -3 | 0.666 |
P38G |
0.698 | 0.134 | 1 | 0.624 |
GRK3 |
0.698 | 0.121 | -2 | 0.480 |
CDK14 |
0.698 | 0.125 | 1 | 0.697 |
CK1G1 |
0.697 | 0.172 | -3 | 0.741 |
PDHK4_TYR |
0.697 | 0.256 | 2 | 0.723 |
CDK5 |
0.697 | 0.123 | 1 | 0.729 |
RAF1 |
0.697 | -0.015 | 1 | 0.700 |
CAMK2G |
0.696 | 0.014 | 2 | 0.643 |
CAMLCK |
0.696 | 0.018 | -2 | 0.614 |
NDR1 |
0.696 | -0.008 | -3 | 0.658 |
SRPK2 |
0.695 | 0.047 | -3 | 0.536 |
DLK |
0.695 | 0.091 | 1 | 0.718 |
IKKA |
0.695 | 0.049 | -2 | 0.484 |
MOK |
0.695 | 0.227 | 1 | 0.765 |
MPSK1 |
0.695 | 0.248 | 1 | 0.709 |
CDK16 |
0.695 | 0.138 | 1 | 0.640 |
MLK1 |
0.695 | 0.010 | 2 | 0.620 |
GRK4 |
0.695 | 0.063 | -2 | 0.587 |
CDK13 |
0.694 | 0.098 | 1 | 0.685 |
MLK3 |
0.694 | 0.071 | 2 | 0.571 |
DYRK3 |
0.694 | 0.096 | 1 | 0.746 |
MSK1 |
0.693 | 0.051 | -3 | 0.585 |
BMPR2 |
0.693 | -0.090 | -2 | 0.610 |
CAMK2D |
0.693 | 0.026 | -3 | 0.631 |
LATS2 |
0.693 | 0.021 | -5 | 0.470 |
CLK1 |
0.692 | 0.065 | -3 | 0.556 |
SRPK3 |
0.692 | 0.025 | -3 | 0.589 |
PAK1 |
0.691 | 0.034 | -2 | 0.615 |
NIK |
0.691 | -0.039 | -3 | 0.673 |
ERK2 |
0.691 | 0.118 | 1 | 0.693 |
MAP2K6_TYR |
0.690 | 0.175 | -1 | 0.831 |
PRP4 |
0.690 | 0.080 | -3 | 0.647 |
MLK2 |
0.690 | 0.051 | 2 | 0.645 |
PDHK4 |
0.690 | -0.115 | 1 | 0.721 |
HIPK3 |
0.690 | 0.110 | 1 | 0.710 |
NUAK2 |
0.689 | -0.047 | -3 | 0.658 |
MASTL |
0.689 | -0.047 | -2 | 0.581 |
CDK12 |
0.689 | 0.095 | 1 | 0.661 |
MAPKAPK3 |
0.688 | 0.012 | -3 | 0.584 |
TBK1 |
0.688 | -0.019 | 1 | 0.563 |
PKN2 |
0.688 | -0.048 | -3 | 0.650 |
WNK1 |
0.688 | -0.038 | -2 | 0.645 |
P70S6KB |
0.688 | -0.007 | -3 | 0.600 |
ACVR2B |
0.688 | 0.059 | -2 | 0.519 |
JNK1 |
0.688 | 0.122 | 1 | 0.666 |
PKCD |
0.687 | -0.010 | 2 | 0.614 |
TGFBR1 |
0.687 | 0.032 | -2 | 0.541 |
MST4 |
0.687 | -0.030 | 2 | 0.682 |
PDHK1_TYR |
0.686 | 0.164 | -1 | 0.842 |
ALK4 |
0.686 | 0.017 | -2 | 0.557 |
PKN3 |
0.686 | -0.052 | -3 | 0.639 |
MAP2K4_TYR |
0.686 | 0.153 | -1 | 0.822 |
FAM20C |
0.686 | 0.029 | 2 | 0.476 |
PKCA |
0.686 | 0.008 | 2 | 0.566 |
MYLK4 |
0.686 | 0.000 | -2 | 0.563 |
RIPK1 |
0.685 | -0.052 | 1 | 0.694 |
AURB |
0.685 | 0.016 | -2 | 0.500 |
MNK1 |
0.684 | 0.017 | -2 | 0.574 |
BMPR1A |
0.684 | 0.063 | 1 | 0.788 |
BMPR2_TYR |
0.684 | 0.077 | -1 | 0.833 |
RSK3 |
0.684 | -0.014 | -3 | 0.578 |
AMPKA1 |
0.684 | -0.024 | -3 | 0.662 |
IKKE |
0.684 | -0.056 | 1 | 0.557 |
TESK1_TYR |
0.684 | 0.075 | 3 | 0.760 |
MSK2 |
0.684 | -0.004 | -3 | 0.598 |
TGFBR2 |
0.684 | -0.080 | -2 | 0.533 |
ACVR2A |
0.683 | 0.025 | -2 | 0.515 |
PKCB |
0.683 | -0.009 | 2 | 0.564 |
PKCG |
0.682 | -0.018 | 2 | 0.577 |
MLK4 |
0.682 | 0.022 | 2 | 0.544 |
PKCZ |
0.682 | 0.006 | 2 | 0.614 |
PKG2 |
0.682 | 0.002 | -2 | 0.501 |
GAK |
0.682 | 0.099 | 1 | 0.784 |
BUB1 |
0.682 | 0.144 | -5 | 0.591 |
DRAK1 |
0.681 | 0.032 | 1 | 0.767 |
MNK2 |
0.681 | 0.004 | -2 | 0.572 |
DSTYK |
0.681 | -0.138 | 2 | 0.694 |
PKR |
0.681 | -0.025 | 1 | 0.725 |
ANKRD3 |
0.681 | -0.109 | 1 | 0.726 |
NEK6 |
0.680 | -0.079 | -2 | 0.557 |
MST3 |
0.680 | 0.035 | 2 | 0.670 |
AURA |
0.680 | 0.004 | -2 | 0.490 |
CK2A1 |
0.680 | 0.132 | 1 | 0.740 |
ATM |
0.680 | -0.003 | 1 | 0.692 |
VRK2 |
0.680 | -0.014 | 1 | 0.762 |
GCN2 |
0.680 | -0.170 | 2 | 0.619 |
CK2A2 |
0.680 | 0.099 | 1 | 0.750 |
CDK9 |
0.679 | 0.057 | 1 | 0.687 |
PKMYT1_TYR |
0.679 | 0.003 | 3 | 0.753 |
AMPKA2 |
0.679 | -0.015 | -3 | 0.635 |
LIMK2_TYR |
0.679 | 0.065 | -3 | 0.673 |
PAK3 |
0.679 | -0.026 | -2 | 0.587 |
PLK1 |
0.679 | -0.026 | -2 | 0.525 |
IRE1 |
0.679 | -0.052 | 1 | 0.681 |
TXK |
0.679 | 0.115 | 1 | 0.812 |
TSSK2 |
0.678 | -0.056 | -5 | 0.602 |
AKT2 |
0.678 | 0.000 | -3 | 0.531 |
PIM2 |
0.678 | 0.006 | -3 | 0.561 |
MEK1 |
0.678 | -0.049 | 2 | 0.674 |
PAK2 |
0.678 | -0.016 | -2 | 0.594 |
ALK2 |
0.678 | 0.003 | -2 | 0.543 |
TLK2 |
0.678 | 0.002 | 1 | 0.665 |
MARK4 |
0.678 | -0.085 | 4 | 0.528 |
TTBK2 |
0.677 | -0.066 | 2 | 0.561 |
SMG1 |
0.677 | 0.002 | 1 | 0.694 |
YANK3 |
0.677 | 0.067 | 2 | 0.377 |
CHAK1 |
0.677 | 0.007 | 2 | 0.664 |
ULK2 |
0.676 | -0.188 | 2 | 0.613 |
NEK7 |
0.676 | -0.159 | -3 | 0.668 |
PKACA |
0.676 | 0.017 | -2 | 0.466 |
TSSK1 |
0.676 | -0.039 | -3 | 0.676 |
DAPK3 |
0.676 | 0.019 | -3 | 0.629 |
TNK2 |
0.675 | 0.084 | 3 | 0.705 |
CDK2 |
0.675 | 0.026 | 1 | 0.756 |
HUNK |
0.675 | -0.157 | 2 | 0.643 |
DAPK1 |
0.675 | 0.033 | -3 | 0.625 |
EPHB4 |
0.675 | 0.064 | -1 | 0.758 |
MAP2K7_TYR |
0.675 | -0.058 | 2 | 0.688 |
CAMK4 |
0.675 | -0.083 | -3 | 0.627 |
PDHK1 |
0.674 | -0.220 | 1 | 0.680 |
PRKD3 |
0.674 | -0.022 | -3 | 0.552 |
MEKK3 |
0.673 | -0.040 | 1 | 0.678 |
TAO3 |
0.673 | 0.023 | 1 | 0.660 |
YSK4 |
0.673 | -0.069 | 1 | 0.619 |
GCK |
0.673 | 0.077 | 1 | 0.682 |
DNAPK |
0.672 | 0.024 | 1 | 0.589 |
DCAMKL1 |
0.672 | -0.021 | -3 | 0.604 |
CAMK1G |
0.671 | -0.033 | -3 | 0.569 |
SGK3 |
0.671 | -0.027 | -3 | 0.590 |
PKCH |
0.671 | -0.063 | 2 | 0.545 |
QSK |
0.671 | -0.051 | 4 | 0.496 |
FGR |
0.670 | -0.002 | 1 | 0.760 |
NEK9 |
0.670 | -0.158 | 2 | 0.645 |
ULK1 |
0.669 | -0.166 | -3 | 0.605 |
PINK1_TYR |
0.669 | -0.118 | 1 | 0.724 |
MEK5 |
0.669 | -0.108 | 2 | 0.649 |
SMMLCK |
0.669 | -0.042 | -3 | 0.618 |
EPHA6 |
0.668 | -0.029 | -1 | 0.798 |
EPHA4 |
0.668 | 0.023 | 2 | 0.646 |
CK1G2 |
0.668 | 0.165 | -3 | 0.705 |
BCKDK |
0.668 | -0.149 | -1 | 0.735 |
PHKG1 |
0.667 | -0.073 | -3 | 0.646 |
ABL2 |
0.667 | 0.031 | -1 | 0.735 |
PTK2 |
0.667 | 0.083 | -1 | 0.754 |
PKCE |
0.667 | -0.016 | 2 | 0.562 |
CK1G3 |
0.667 | 0.174 | -3 | 0.659 |
WNK3 |
0.667 | -0.202 | 1 | 0.659 |
LKB1 |
0.667 | 0.060 | -3 | 0.652 |
MEKK2 |
0.666 | -0.075 | 2 | 0.616 |
CDK6 |
0.666 | 0.072 | 1 | 0.672 |
NEK11 |
0.666 | -0.034 | 1 | 0.654 |
NIM1 |
0.666 | -0.115 | 3 | 0.664 |
ERK7 |
0.666 | 0.027 | 2 | 0.433 |
FYN |
0.666 | 0.051 | -1 | 0.765 |
YES1 |
0.665 | -0.006 | -1 | 0.790 |
NEK5 |
0.665 | -0.066 | 1 | 0.695 |
LIMK1_TYR |
0.665 | -0.107 | 2 | 0.678 |
IRE2 |
0.665 | -0.087 | 2 | 0.563 |
BLK |
0.665 | 0.034 | -1 | 0.774 |
MET |
0.665 | 0.020 | 3 | 0.716 |
ROCK2 |
0.664 | 0.023 | -3 | 0.615 |
LCK |
0.664 | 0.025 | -1 | 0.772 |
PLK3 |
0.664 | -0.052 | 2 | 0.625 |
MARK3 |
0.664 | -0.065 | 4 | 0.469 |
CDK4 |
0.664 | 0.078 | 1 | 0.653 |
ABL1 |
0.663 | 0.013 | -1 | 0.726 |
MELK |
0.663 | -0.096 | -3 | 0.598 |
SYK |
0.663 | 0.082 | -1 | 0.724 |
SRMS |
0.663 | 0.008 | 1 | 0.768 |
NUAK1 |
0.662 | -0.091 | -3 | 0.585 |
QIK |
0.662 | -0.142 | -3 | 0.631 |
CSF1R |
0.662 | -0.014 | 3 | 0.718 |
CHK1 |
0.662 | -0.089 | -3 | 0.603 |
ZAK |
0.662 | -0.110 | 1 | 0.632 |
BRSK1 |
0.662 | -0.072 | -3 | 0.597 |
RET |
0.662 | -0.085 | 1 | 0.647 |
HPK1 |
0.661 | 0.004 | 1 | 0.661 |
SIK |
0.661 | -0.074 | -3 | 0.571 |
SGK1 |
0.661 | 0.006 | -3 | 0.480 |
CAMK1D |
0.661 | -0.018 | -3 | 0.501 |
TLK1 |
0.661 | -0.090 | -2 | 0.560 |
AKT1 |
0.660 | -0.024 | -3 | 0.548 |
PINK1 |
0.660 | -0.120 | 1 | 0.761 |
MAPKAPK5 |
0.660 | -0.075 | -3 | 0.537 |
PAK6 |
0.660 | -0.044 | -2 | 0.511 |
DDR1 |
0.660 | -0.086 | 4 | 0.557 |
ITK |
0.660 | -0.022 | -1 | 0.726 |
DCAMKL2 |
0.660 | -0.059 | -3 | 0.598 |
DDR2 |
0.660 | 0.057 | 3 | 0.657 |
PLK2 |
0.660 | 0.011 | -3 | 0.585 |
KIT |
0.659 | -0.029 | 3 | 0.723 |
MST1R |
0.659 | -0.100 | 3 | 0.725 |
MEKK1 |
0.659 | -0.135 | 1 | 0.660 |
INSRR |
0.659 | -0.033 | 3 | 0.655 |
FER |
0.659 | -0.070 | 1 | 0.774 |
BMX |
0.659 | 0.010 | -1 | 0.660 |
PLK4 |
0.659 | -0.112 | 2 | 0.501 |
IRAK4 |
0.659 | -0.085 | 1 | 0.666 |
EPHB1 |
0.658 | -0.016 | 1 | 0.746 |
CAMKK2 |
0.658 | -0.037 | -2 | 0.496 |
KDR |
0.658 | -0.054 | 3 | 0.696 |
TYRO3 |
0.658 | -0.112 | 3 | 0.693 |
PDK1 |
0.658 | -0.063 | 1 | 0.649 |
AKT3 |
0.658 | -0.004 | -3 | 0.500 |
MRCKA |
0.657 | -0.002 | -3 | 0.566 |
PBK |
0.657 | 0.031 | 1 | 0.706 |
SLK |
0.657 | -0.008 | -2 | 0.507 |
MST2 |
0.657 | -0.052 | 1 | 0.672 |
FLT1 |
0.657 | -0.013 | -1 | 0.764 |
STK33 |
0.657 | -0.041 | 2 | 0.527 |
EPHB2 |
0.657 | -0.010 | -1 | 0.730 |
NEK2 |
0.657 | -0.146 | 2 | 0.645 |
ROS1 |
0.656 | -0.091 | 3 | 0.664 |
DMPK1 |
0.656 | 0.006 | -3 | 0.581 |
PERK |
0.656 | -0.158 | -2 | 0.548 |
MAP3K15 |
0.656 | -0.015 | 1 | 0.606 |
HCK |
0.656 | -0.052 | -1 | 0.762 |
PKCI |
0.656 | -0.067 | 2 | 0.580 |
KHS2 |
0.656 | 0.013 | 1 | 0.651 |
BRAF |
0.656 | -0.142 | -4 | 0.662 |
EPHB3 |
0.656 | -0.031 | -1 | 0.736 |
LRRK2 |
0.656 | -0.061 | 2 | 0.674 |
BRSK2 |
0.655 | -0.107 | -3 | 0.602 |
SSTK |
0.655 | -0.076 | 4 | 0.477 |
P70S6K |
0.655 | -0.049 | -3 | 0.520 |
MERTK |
0.655 | -0.023 | 3 | 0.703 |
JAK3 |
0.655 | -0.083 | 1 | 0.637 |
EPHA7 |
0.655 | -0.007 | 2 | 0.644 |
PAK4 |
0.655 | -0.016 | -2 | 0.520 |
WNK4 |
0.655 | -0.127 | -2 | 0.630 |
EEF2K |
0.654 | -0.023 | 3 | 0.692 |
MARK2 |
0.654 | -0.116 | 4 | 0.436 |
SBK |
0.654 | 0.008 | -3 | 0.423 |
JAK2 |
0.654 | -0.096 | 1 | 0.627 |
TNIK |
0.654 | -0.024 | 3 | 0.749 |
PTK2B |
0.654 | 0.009 | -1 | 0.696 |
PKCT |
0.654 | -0.090 | 2 | 0.555 |
TAK1 |
0.653 | -0.059 | 1 | 0.671 |
YANK2 |
0.653 | 0.062 | 2 | 0.381 |
NEK8 |
0.652 | -0.139 | 2 | 0.638 |
KHS1 |
0.652 | 0.004 | 1 | 0.623 |
EPHA3 |
0.652 | -0.038 | 2 | 0.619 |
TNK1 |
0.652 | -0.043 | 3 | 0.690 |
MRCKB |
0.652 | -0.025 | -3 | 0.551 |
MINK |
0.652 | -0.058 | 1 | 0.635 |
FGFR2 |
0.652 | -0.102 | 3 | 0.719 |
PAK5 |
0.652 | -0.039 | -2 | 0.500 |
CHK2 |
0.651 | -0.036 | -3 | 0.473 |
HASPIN |
0.651 | 0.030 | -1 | 0.725 |
CAMKK1 |
0.650 | -0.138 | -2 | 0.482 |
TAO2 |
0.650 | -0.115 | 2 | 0.671 |
TTK |
0.650 | -0.013 | -2 | 0.566 |
HGK |
0.650 | -0.056 | 3 | 0.751 |
SRC |
0.650 | -0.012 | -1 | 0.751 |
MARK1 |
0.650 | -0.122 | 4 | 0.472 |
ZAP70 |
0.649 | 0.048 | -1 | 0.669 |
VRK1 |
0.649 | -0.081 | 2 | 0.654 |
TYK2 |
0.649 | -0.194 | 1 | 0.632 |
CRIK |
0.649 | 0.008 | -3 | 0.551 |
MST1 |
0.648 | -0.048 | 1 | 0.640 |
EPHA8 |
0.648 | -0.011 | -1 | 0.736 |
EPHA5 |
0.648 | -0.016 | 2 | 0.626 |
SNRK |
0.648 | -0.192 | 2 | 0.543 |
OSR1 |
0.648 | -0.025 | 2 | 0.640 |
TTBK1 |
0.648 | -0.106 | 2 | 0.508 |
CAMK1A |
0.648 | -0.027 | -3 | 0.486 |
ALPHAK3 |
0.648 | 0.057 | -1 | 0.732 |
MATK |
0.647 | -0.045 | -1 | 0.683 |
AXL |
0.647 | -0.079 | 3 | 0.698 |
MEKK6 |
0.647 | -0.122 | 1 | 0.649 |
WEE1_TYR |
0.647 | -0.079 | -1 | 0.705 |
HRI |
0.647 | -0.219 | -2 | 0.563 |
FGFR3 |
0.646 | -0.080 | 3 | 0.697 |
JAK1 |
0.646 | -0.041 | 1 | 0.569 |
LYN |
0.645 | -0.061 | 3 | 0.649 |
LOK |
0.645 | -0.073 | -2 | 0.527 |
PDGFRB |
0.645 | -0.148 | 3 | 0.709 |
ERBB4 |
0.645 | 0.006 | 1 | 0.616 |
NEK4 |
0.645 | -0.128 | 1 | 0.636 |
TEC |
0.645 | -0.081 | -1 | 0.656 |
NEK1 |
0.644 | -0.092 | 1 | 0.652 |
ERBB2 |
0.644 | -0.092 | 1 | 0.626 |
ROCK1 |
0.643 | -0.026 | -3 | 0.567 |
TNNI3K_TYR |
0.643 | -0.107 | 1 | 0.667 |
NTRK1 |
0.642 | -0.109 | -1 | 0.741 |
FRK |
0.641 | -0.080 | -1 | 0.757 |
TEK |
0.641 | -0.173 | 3 | 0.652 |
FGFR4 |
0.641 | -0.029 | -1 | 0.692 |
NEK10_TYR |
0.641 | -0.080 | 1 | 0.511 |
FLT3 |
0.641 | -0.175 | 3 | 0.706 |
NTRK3 |
0.640 | -0.056 | -1 | 0.696 |
EPHA1 |
0.640 | -0.092 | 3 | 0.702 |
CSK |
0.640 | -0.030 | 2 | 0.636 |
BIKE |
0.640 | 0.011 | 1 | 0.698 |
ALK |
0.640 | -0.105 | 3 | 0.621 |
EGFR |
0.640 | -0.045 | 1 | 0.548 |
LTK |
0.639 | -0.111 | 3 | 0.655 |
FGFR1 |
0.638 | -0.163 | 3 | 0.674 |
PTK6 |
0.638 | -0.118 | -1 | 0.653 |
EPHA2 |
0.638 | -0.026 | -1 | 0.695 |
INSR |
0.638 | -0.104 | 3 | 0.638 |
BTK |
0.637 | -0.163 | -1 | 0.687 |
FLT4 |
0.637 | -0.142 | 3 | 0.689 |
PKN1 |
0.636 | -0.091 | -3 | 0.531 |
PDGFRA |
0.636 | -0.172 | 3 | 0.708 |
PHKG2 |
0.634 | -0.150 | -3 | 0.585 |
YSK1 |
0.633 | -0.131 | 2 | 0.625 |
IRAK1 |
0.633 | -0.256 | -1 | 0.710 |
MYO3B |
0.633 | -0.069 | 2 | 0.658 |
AAK1 |
0.631 | 0.041 | 1 | 0.621 |
ASK1 |
0.631 | -0.073 | 1 | 0.592 |
NTRK2 |
0.630 | -0.168 | 3 | 0.676 |
IGF1R |
0.628 | -0.081 | 3 | 0.585 |
MEK2 |
0.628 | -0.215 | 2 | 0.638 |
MYO3A |
0.628 | -0.096 | 1 | 0.642 |
PKG1 |
0.625 | -0.077 | -2 | 0.432 |
FES |
0.624 | -0.053 | -1 | 0.638 |
RIPK2 |
0.623 | -0.226 | 1 | 0.578 |
TAO1 |
0.618 | -0.120 | 1 | 0.557 |
STLK3 |
0.614 | -0.145 | 1 | 0.592 |
MUSK |
0.613 | -0.142 | 1 | 0.538 |
NEK3 |
0.609 | -0.251 | 1 | 0.593 |