Motif 179 (n=175)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6ND36 | FAM83G | S124 | ochoa | Protein FAM83G (Protein associated with SMAD1) | Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}. |
| O00512 | BCL9 | S154 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14978 | ZNF263 | S155 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
| O15085 | ARHGEF11 | S592 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15231 | ZNF185 | S601 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
| O15357 | INPPL1 | S151 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O43149 | ZZEF1 | S1464 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
| O60292 | SIPA1L3 | S1162 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60315 | ZEB2 | S64 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O75376 | NCOR1 | S1266 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75815 | BCAR3 | S352 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O94875 | SORBS2 | S288 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
| O94916 | NFAT5 | S145 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95235 | KIF20A | S867 | ochoa|psp | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
| O95425 | SVIL | S231 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
| O95644 | NFATC1 | S161 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O95817 | BAG3 | S268 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| P04040 | CAT | S167 | psp | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| P05023 | ATP1A1 | S499 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P13639 | EEF2 | S584 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P13688 | CEACAM1 | S494 | psp | Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) | [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}. |
| P14317 | HCLS1 | S314 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P19634 | SLC9A1 | S703 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P20340 | RAB6A | S184 | ochoa | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable). {ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:25962623, ECO:0000305|PubMed:25492866}. |
| P20701 | ITGAL | S1145 | ochoa | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:38195629}. |
| P21333 | FLNA | S1522 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21333 | FLNA | S2213 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P21580 | TNFAIP3 | S381 | ochoa|psp | Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37] | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. {ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:15258597, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:18952128, ECO:0000269|PubMed:19494296, ECO:0000269|PubMed:22099304, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:8692885, ECO:0000269|PubMed:9299557, ECO:0000269|PubMed:9882303}. |
| P35568 | IRS1 | S330 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35637 | FUS | S30 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P46527 | CDKN1B | S83 | psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
| P49023 | PXN | S95 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49023 | PXN | S109 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49792 | RANBP2 | S1018 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50479 | PDLIM4 | S165 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P52732 | KIF11 | S931 | ochoa | Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}. |
| P52799 | EFNB2 | S284 | ochoa | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| P53602 | MVD | S211 | ochoa | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}. |
| P54198 | HIRA | S538 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54725 | RAD23A | S102 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P56856 | CLDN18 | S210 | ochoa | Claudin-18 | Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection. {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000250|UniProtKB:P56857}. |
| P57679 | EVC | S138 | ochoa | EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein) | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250|UniProtKB:P57680}. |
| P57682 | KLF3 | S81 | ochoa | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P78312 | FAM193A | S972 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78559 | MAP1A | S899 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q00587 | CDC42EP1 | S132 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
| Q02156 | PRKCE | S339 | ochoa | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q05209 | PTPN12 | S588 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07157 | TJP1 | S878 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q08AM6 | VAC14 | S509 | ochoa | Protein VAC14 homolog (Tax1-binding protein 2) | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}. |
| Q12789 | GTF3C1 | S1845 | ochoa | General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element. |
| Q12888 | TP53BP1 | S1219 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1645 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13112 | CHAF1B | S513 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13112 | CHAF1B | S520 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13242 | SRSF9 | S193 | ochoa | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}. |
| Q13425 | SNTB2 | S211 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q13472 | TOP3A | S771 | ochoa | DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha) | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2 (PubMed:29290614). {ECO:0000269|PubMed:20445207, ECO:0000269|PubMed:29290614, ECO:0000269|PubMed:30057030, ECO:0000269|PubMed:8622991}. |
| Q13884 | SNTB1 | S208 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q13950 | RUNX2 | S378 | psp | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q13952 | NFYC | S342 | ochoa | Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2) | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| Q14315 | FLNC | S2016 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14676 | MDC1 | S1681 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14687 | GSE1 | S703 | ochoa | Genetic suppressor element 1 | None |
| Q15772 | SPEG | S559 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16204 | CCDC6 | Y356 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16594 | TAF9 | S155 | ochoa | Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866). TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866). Essential for cell viability (PubMed:15899866). May have a role in gene regulation associated with apoptosis (PubMed:15899866). {ECO:0000269|PubMed:15899866, ECO:0000269|PubMed:33795473}. |
| Q16799 | RTN1 | S321 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2KHR3 | QSER1 | S498 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q53ET0 | CRTC2 | S613 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q5BJF6 | ODF2 | S95 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5R372 | RABGAP1L | S108 | ochoa | Rab GTPase-activating protein 1-like | GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}. |
| Q5T0Z8 | C6orf132 | S1087 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T200 | ZC3H13 | S335 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5T481 | RBM20 | S1060 | ochoa | RNA-binding protein 20 (RNA-binding motif protein 20) | RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}. |
| Q5VST9 | OBSCN | S125 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VWQ0 | RSBN1 | S91 | ochoa | Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1) | Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}. |
| Q5VY43 | PEAR1 | S933 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q5VYS8 | TUT7 | S74 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q66K74 | MAP1S | S571 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DQ2 | CRYBG3 | S618 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q69YQ0 | SPECC1L | S921 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6BDS2 | BLTP3A | S957 | ochoa | Bridge-like lipid transfer protein family member 3A (ICBP90-binding protein 1) (UHRF1-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) | Tube-forming lipid transport protein which probably mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). May be involved in the retrograde traffic of vesicle clusters in the endocytic pathway to the Golgi complex (PubMed:35499567). {ECO:0000269|PubMed:35499567}. |
| Q6IQ26 | DENND5A | S1068 | ochoa | DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) | Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Q6P0Q8 | MAST2 | S1351 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P1R3 | MSANTD2 | S37 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6P597 | KLC3 | S167 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6PFW1 | PPIP5K1 | S987 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6VMQ6 | ATF7IP | S888 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6XZF7 | DNMBP | S1419 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZUT6 | CCDC9B | S212 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q76I76 | SSH2 | S1216 | ochoa | Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}. |
| Q7L9B9 | EEPD1 | S247 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7Z3C6 | ATG9A | S741 | ochoa | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z3K3 | POGZ | S710 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q86U44 | METTL3 | S358 | ochoa | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86UU0 | BCL9L | S915 | ochoa | B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) | Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}. |
| Q86VP1 | TAX1BP1 | S694 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q8IVF2 | AHNAK2 | S38 | ochoa | Protein AHNAK2 | None |
| Q8IVL1 | NAV2 | S1582 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWR0 | ZC3H7A | S318 | ochoa | Zinc finger CCCH domain-containing protein 7A | May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}. |
| Q8N137 | CNTROB | S743 | ochoa | Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. {ECO:0000269|PubMed:16275750}. |
| Q8N680 | ZBTB2 | S115 | psp | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8ND24 | RNF214 | S500 | ochoa | RING finger protein 214 | None |
| Q8ND30 | PPFIBP2 | S414 | ochoa | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q8ND56 | LSM14A | S172 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8NDF8 | TENT4B | S45 | ochoa | Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}. |
| Q8NDT2 | RBM15B | S598 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8NEM0 | MCPH1 | S322 | ochoa|psp | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NHG8 | ZNRF2 | S119 | ochoa | E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2) | E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases (PubMed:27244671). In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism (PubMed:27244671). {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}. |
| Q8NI77 | KIF18A | S695 | ochoa | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. {ECO:0000269|PubMed:17346968, ECO:0000269|PubMed:18267093, ECO:0000269|PubMed:18513970, ECO:0000269|PubMed:19625775}. |
| Q8TDM6 | DLG5 | S1265 | ochoa | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) | Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}. |
| Q8TDY2 | RB1CC1 | S212 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEW0 | PARD3 | S1234 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WUY3 | PRUNE2 | S586 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92574 | TSC1 | S350 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92915 | FGF14 | S228 | psp | Fibroblast growth factor 14 (FGF-14) (Fibroblast growth factor homologous factor 4) (FHF-4) | Probably involved in nervous system development and function. |
| Q96AV8 | E2F7 | S829 | ochoa | Transcription factor E2F7 (E2F-7) | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269|PubMed:14633988, ECO:0000269|PubMed:15133492, ECO:0000269|PubMed:18202719, ECO:0000269|PubMed:19223542, ECO:0000269|PubMed:21248772, ECO:0000269|PubMed:22802528, ECO:0000269|PubMed:22802529, ECO:0000269|PubMed:22903062}. |
| Q96B97 | SH3KBP1 | S500 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
| Q96FS4 | SIPA1 | S770 | ochoa | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity). {ECO:0000250|UniProtKB:P46062, ECO:0000269|PubMed:9346962}. |
| Q96I24 | FUBP3 | S442 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96JH7 | VCPIP1 | S757 | ochoa | Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein) | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis (PubMed:32649882). Necessary for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs) (PubMed:32649882). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (PubMed:23827681). {ECO:0000250|UniProtKB:Q8CF97, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:32649882}.; FUNCTION: (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. {ECO:0000269|PubMed:28584101}. |
| Q96MY1 | NOL4L | S137 | ochoa | Nucleolar protein 4-like | None |
| Q96PN7 | TRERF1 | S756 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96QS3 | ARX | S174 | psp | Homeobox protein ARX (Aristaless-related homeobox) | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}. |
| Q96RD7 | PANX1 | S182 | ochoa | Pannexin-1 (PANX1) [Cleaved into: Caspase-activated pannexin-1 (Caspase-activated PANX1)] | Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). {ECO:0000250|UniProtKB:Q9JIP4, ECO:0000269|PubMed:15304325, ECO:0000269|PubMed:16908669, ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926}.; FUNCTION: [Caspase-activated pannexin-1]: During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells. {ECO:0000269|PubMed:20944749, ECO:0000269|PubMed:32238926, ECO:0000269|PubMed:32494015}. |
| Q99567 | NUP88 | S168 | ochoa | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | Component of nuclear pore complex. {ECO:0000269|PubMed:30543681}. |
| Q9BX66 | SORBS1 | S151 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BX66 | SORBS1 | S1034 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9C0B0 | UNK | S367 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0C2 | TNKS1BP1 | S279 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0F6 | SHARPIN | S146 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9H0W8 | SMG9 | S32 | ochoa | Nonsense-mediated mRNA decay factor SMG9 | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (PubMed:19417104). Plays a role in brain, heart, and eye development (By similarity). {ECO:0000250|UniProtKB:Q9DB90, ECO:0000269|PubMed:19417104}. |
| Q9H1E3 | NUCKS1 | S214 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H400 | LIME1 | S201 | ochoa | Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule) | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}. |
| Q9H5H4 | ZNF768 | Y121 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H792 | PEAK1 | S826 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H8N7 | ZNF395 | S377 | ochoa | Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor) | Plays a role in papillomavirus genes transcription. |
| Q9HCD6 | TANC2 | S252 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCH5 | SYTL2 | S311 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCK8 | CHD8 | S2202 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQU5 | PAK6 | S308 | ochoa|psp | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
| Q9NRR5 | UBQLN4 | S100 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9P0V3 | SH3BP4 | S120 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P2N6 | KANSL3 | S525 | ochoa | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity). {ECO:0000250|UniProtKB:A2RSY1, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q9UDY2 | TJP2 | S953 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UHB6 | LIMA1 | S114 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UJM3 | ERRFI1 | S390 | ochoa | ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6) | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). {ECO:0000250}. |
| Q9UK80 | USP21 | S335 | psp | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (By similarity). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (By similarity). Regulates gene expression via histone H2A deubiquitination (By similarity). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). {ECO:0000250|UniProtKB:Q9QZL6, ECO:0000269|PubMed:10799498, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:32011234}. |
| Q9UKW4 | VAV3 | S604 | ochoa | Guanine nucleotide exchange factor VAV3 (VAV-3) | Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
| Q9ULH1 | ASAP1 | S1002 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULV4 | CORO1C | S309 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9UMS6 | SYNPO2 | S770 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPQ0 | LIMCH1 | S611 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | S322 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S913 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1053 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1198 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1218 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1300 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1423 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1541 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1581 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H5 | PLEKHA6 | S794 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y2W1 | THRAP3 | S253 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y6A5 | TACC3 | S583 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6J0 | CABIN1 | S2100 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| O43283 | MAP3K13 | S684 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P17174 | GOT1 | S82 | Sugiyama | Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A) | Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}. |
| P33993 | MCM7 | S392 | Sugiyama | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage. {ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15538388, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P14616 | INSRR | S1271 | Sugiyama | Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269|PubMed:21641549}. |
| Q9H1A4 | ANAPC1 | S323 | Sugiyama | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q15642 | TRIP10 | S288 | Sugiyama | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10) | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}. |
| P50851 | LRBA | S1725 | Sugiyama | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| A0AVT1 | UBA6 | S732 | Sugiyama | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.002234 | 2.651 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.003018 | 2.520 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.003458 | 2.461 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.001655 | 2.781 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.003622 | 2.441 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 0.003018 | 2.520 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.003913 | 2.407 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.001431 | 2.844 |
| R-HSA-73887 | Death Receptor Signaling | 0.003892 | 2.410 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.001743 | 2.759 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.006672 | 2.176 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 0.006024 | 2.220 |
| R-HSA-75893 | TNF signaling | 0.006547 | 2.184 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.006905 | 2.161 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.007234 | 2.141 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.007234 | 2.141 |
| R-HSA-983189 | Kinesins | 0.008057 | 2.094 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.009051 | 2.043 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.009774 | 2.010 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.011459 | 1.941 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.011459 | 1.941 |
| R-HSA-74713 | IRS activation | 0.076886 | 1.114 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.087379 | 1.059 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.087379 | 1.059 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.016524 | 1.782 |
| R-HSA-112412 | SOS-mediated signalling | 0.108010 | 0.967 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.157580 | 0.802 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.176632 | 0.753 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.064441 | 1.191 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.067577 | 1.170 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.067577 | 1.170 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.195256 | 0.709 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.073997 | 1.131 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.073997 | 1.131 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.077277 | 1.112 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.204410 | 0.689 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.204410 | 0.689 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.083972 | 1.076 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.045405 | 1.343 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.097858 | 1.009 |
| R-HSA-3928664 | Ephrin signaling | 0.231255 | 0.636 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.101425 | 0.994 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.240002 | 0.620 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.240002 | 0.620 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.248650 | 0.604 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.248650 | 0.604 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.248650 | 0.604 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.257199 | 0.590 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.066667 | 1.176 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.265652 | 0.576 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.085079 | 1.070 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.298519 | 0.525 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.329922 | 0.482 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.291550 | 0.535 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.291550 | 0.535 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.195612 | 0.709 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.087383 | 1.059 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.337551 | 0.472 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.058325 | 1.234 |
| R-HSA-198203 | PI3K/AKT activation | 0.138089 | 0.860 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.248650 | 0.604 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.274010 | 0.562 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.129653 | 0.887 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.048673 | 1.313 |
| R-HSA-191650 | Regulation of gap junction activity | 0.066273 | 1.179 |
| R-HSA-9609690 | HCMV Early Events | 0.232426 | 0.634 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.325058 | 0.488 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.135084 | 0.869 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.097858 | 1.009 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.128177 | 0.892 |
| R-HSA-420029 | Tight junction interactions | 0.049561 | 1.305 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.064441 | 1.191 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.222408 | 0.653 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.264311 | 0.578 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.344981 | 0.462 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.078720 | 1.104 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.337551 | 0.472 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 0.157580 | 0.802 |
| R-HSA-6798695 | Neutrophil degranulation | 0.306687 | 0.513 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.175640 | 0.755 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.178714 | 0.748 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.082935 | 1.081 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.131143 | 0.882 |
| R-HSA-5693538 | Homology Directed Repair | 0.192725 | 0.715 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.044682 | 1.350 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.066273 | 1.179 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.066273 | 1.179 |
| R-HSA-8866376 | Reelin signalling pathway | 0.076886 | 1.114 |
| R-HSA-176974 | Unwinding of DNA | 0.128177 | 0.892 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 0.147890 | 0.830 |
| R-HSA-429947 | Deadenylation of mRNA | 0.046756 | 1.330 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 0.167160 | 0.777 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.176632 | 0.753 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.064441 | 1.191 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.213460 | 0.671 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.090836 | 1.042 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.090836 | 1.042 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.123534 | 0.908 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.274010 | 0.562 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.290442 | 0.537 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.322205 | 0.492 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.211699 | 0.674 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.310784 | 0.508 |
| R-HSA-182971 | EGFR downregulation | 0.067577 | 1.170 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.337551 | 0.472 |
| R-HSA-74749 | Signal attenuation | 0.138089 | 0.860 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.222408 | 0.653 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.108010 | 0.967 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.070763 | 1.150 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.077277 | 1.112 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.248650 | 0.604 |
| R-HSA-9707616 | Heme signaling | 0.190997 | 0.719 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.067577 | 1.170 |
| R-HSA-2424491 | DAP12 signaling | 0.337551 | 0.472 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.329222 | 0.483 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.228413 | 0.641 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.157580 | 0.802 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.185997 | 0.730 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.213460 | 0.671 |
| R-HSA-159424 | Conjugation of carboxylic acids | 0.240002 | 0.620 |
| R-HSA-156587 | Amino Acid conjugation | 0.240002 | 0.620 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.178714 | 0.748 |
| R-HSA-191859 | snRNP Assembly | 0.178714 | 0.748 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.186889 | 0.728 |
| R-HSA-9610379 | HCMV Late Events | 0.323219 | 0.491 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.134988 | 0.870 |
| R-HSA-69306 | DNA Replication | 0.310784 | 0.508 |
| R-HSA-9842663 | Signaling by LTK | 0.167160 | 0.777 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 0.176632 | 0.753 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.236806 | 0.626 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.080603 | 1.094 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.248650 | 0.604 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.337551 | 0.472 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.028385 | 1.547 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.240002 | 0.620 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.274708 | 0.561 |
| R-HSA-69242 | S Phase | 0.295266 | 0.530 |
| R-HSA-112307 | Transmission across Electrical Synapses | 0.066273 | 1.179 |
| R-HSA-112303 | Electric Transmission Across Gap Junctions | 0.066273 | 1.179 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.118150 | 0.928 |
| R-HSA-428540 | Activation of RAC1 | 0.157580 | 0.802 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.157580 | 0.802 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.167160 | 0.777 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.195256 | 0.709 |
| R-HSA-9945266 | Differentiation of T cells | 0.204410 | 0.689 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.204410 | 0.689 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.213460 | 0.671 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.101425 | 0.994 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.101425 | 0.994 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.105028 | 0.979 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.068613 | 1.164 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.154567 | 0.811 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.314399 | 0.503 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.230606 | 0.637 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.040715 | 1.390 |
| R-HSA-5635838 | Activation of SMO | 0.204410 | 0.689 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.047025 | 1.328 |
| R-HSA-177929 | Signaling by EGFR | 0.037734 | 1.423 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.323219 | 0.491 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.128177 | 0.892 |
| R-HSA-69481 | G2/M Checkpoints | 0.081094 | 1.091 |
| R-HSA-1640170 | Cell Cycle | 0.132154 | 0.879 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.087379 | 1.059 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.020337 | 1.692 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.108010 | 0.967 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.167160 | 0.777 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.167160 | 0.777 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.167160 | 0.777 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.094328 | 1.025 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.231255 | 0.636 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.127325 | 0.895 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.178714 | 0.748 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.232607 | 0.633 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.073300 | 1.135 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.015299 | 1.815 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.107765 | 0.968 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.035234 | 1.453 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.306504 | 0.514 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.276717 | 0.558 |
| R-HSA-68886 | M Phase | 0.180253 | 0.744 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.076649 | 1.115 |
| R-HSA-1989781 | PPARA activates gene expression | 0.317001 | 0.499 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.054943 | 1.260 |
| R-HSA-5689877 | Josephin domain DUBs | 0.138089 | 0.860 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.204410 | 0.689 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.213460 | 0.671 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.097858 | 1.009 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.248650 | 0.604 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.282273 | 0.549 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.282273 | 0.549 |
| R-HSA-2160916 | Hyaluronan degradation | 0.298519 | 0.525 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.073131 | 1.136 |
| R-HSA-1632852 | Macroautophagy | 0.270559 | 0.568 |
| R-HSA-5688426 | Deubiquitination | 0.207876 | 0.682 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.265652 | 0.576 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.298519 | 0.525 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.298519 | 0.525 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.170597 | 0.768 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.122429 | 0.912 |
| R-HSA-199991 | Membrane Trafficking | 0.236904 | 0.625 |
| R-HSA-74160 | Gene expression (Transcription) | 0.068915 | 1.162 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.185997 | 0.730 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.037734 | 1.423 |
| R-HSA-392517 | Rap1 signalling | 0.240002 | 0.620 |
| R-HSA-1237112 | Methionine salvage pathway | 0.240002 | 0.620 |
| R-HSA-8854214 | TBC/RABGAPs | 0.116038 | 0.935 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.322205 | 0.492 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.190997 | 0.719 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.140289 | 0.853 |
| R-HSA-2028269 | Signaling by Hippo | 0.026668 | 1.574 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.282273 | 0.549 |
| R-HSA-397014 | Muscle contraction | 0.274560 | 0.561 |
| R-HSA-212436 | Generic Transcription Pathway | 0.088793 | 1.052 |
| R-HSA-9612973 | Autophagy | 0.320110 | 0.495 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.167160 | 0.777 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.240002 | 0.620 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.290442 | 0.537 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.245215 | 0.610 |
| R-HSA-162587 | HIV Life Cycle | 0.323219 | 0.491 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.189848 | 0.722 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.195116 | 0.710 |
| R-HSA-8848021 | Signaling by PTK6 | 0.195116 | 0.710 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.018389 | 1.735 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.128177 | 0.892 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.167160 | 0.777 |
| R-HSA-8876725 | Protein methylation | 0.195256 | 0.709 |
| R-HSA-2559583 | Cellular Senescence | 0.194444 | 0.711 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.329922 | 0.482 |
| R-HSA-2586552 | Signaling by Leptin | 0.138089 | 0.860 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.265652 | 0.576 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.150607 | 0.822 |
| R-HSA-1483255 | PI Metabolism | 0.140289 | 0.853 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.128177 | 0.892 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.040715 | 1.390 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.074602 | 1.127 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.291550 | 0.535 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.028934 | 1.539 |
| R-HSA-180292 | GAB1 signalosome | 0.231255 | 0.636 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.091649 | 1.038 |
| R-HSA-68875 | Mitotic Prophase | 0.198511 | 0.702 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.182795 | 0.738 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.067577 | 1.170 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.295754 | 0.529 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.338447 | 0.471 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.138089 | 0.860 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.064441 | 1.191 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.274010 | 0.562 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.337551 | 0.472 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.201414 | 0.696 |
| R-HSA-3371556 | Cellular response to heat stress | 0.201420 | 0.696 |
| R-HSA-8983711 | OAS antiviral response | 0.167160 | 0.777 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.240002 | 0.620 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.274010 | 0.562 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.076649 | 1.115 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.053768 | 1.269 |
| R-HSA-162582 | Signal Transduction | 0.303238 | 0.518 |
| R-HSA-109582 | Hemostasis | 0.211901 | 0.674 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.322205 | 0.492 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.245215 | 0.610 |
| R-HSA-446728 | Cell junction organization | 0.128205 | 0.892 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.190997 | 0.719 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.036166 | 1.442 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.108665 | 0.964 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.066667 | 1.176 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.330715 | 0.481 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.240002 | 0.620 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.282273 | 0.549 |
| R-HSA-1500931 | Cell-Cell communication | 0.188438 | 0.725 |
| R-HSA-75153 | Apoptotic execution phase | 0.024592 | 1.609 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.055347 | 1.257 |
| R-HSA-9607240 | FLT3 Signaling | 0.105028 | 0.979 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.038715 | 1.412 |
| R-HSA-195721 | Signaling by WNT | 0.299288 | 0.524 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.044789 | 1.349 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.199247 | 0.701 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.298519 | 0.525 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.073300 | 1.135 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.282273 | 0.549 |
| R-HSA-622312 | Inflammasomes | 0.322205 | 0.492 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.130112 | 0.886 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.270494 | 0.568 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.313892 | 0.503 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.310160 | 0.508 |
| R-HSA-109581 | Apoptosis | 0.338766 | 0.470 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.132507 | 0.878 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.337527 | 0.472 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.337551 | 0.472 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 0.345095 | 0.462 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.345802 | 0.461 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.348458 | 0.458 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.349927 | 0.456 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.349927 | 0.456 |
| R-HSA-69190 | DNA strand elongation | 0.352553 | 0.453 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.352553 | 0.453 |
| R-HSA-3214847 | HATs acetylate histones | 0.358151 | 0.446 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.359926 | 0.444 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.359926 | 0.444 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.359926 | 0.444 |
| R-HSA-9930044 | Nuclear RNA decay | 0.359926 | 0.444 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.359926 | 0.444 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.359926 | 0.444 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.359926 | 0.444 |
| R-HSA-70171 | Glycolysis | 0.362249 | 0.441 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.367216 | 0.435 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.367216 | 0.435 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 0.367216 | 0.435 |
| R-HSA-4839726 | Chromatin organization | 0.369412 | 0.432 |
| R-HSA-9609646 | HCMV Infection | 0.371992 | 0.429 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.374423 | 0.427 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.374423 | 0.427 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.374423 | 0.427 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.374423 | 0.427 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.374423 | 0.427 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.374423 | 0.427 |
| R-HSA-5205647 | Mitophagy | 0.374423 | 0.427 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.381549 | 0.418 |
| R-HSA-381042 | PERK regulates gene expression | 0.381549 | 0.418 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.381549 | 0.418 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.388594 | 0.411 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.388594 | 0.411 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.388594 | 0.411 |
| R-HSA-69239 | Synthesis of DNA | 0.394657 | 0.404 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.394657 | 0.404 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.394657 | 0.404 |
| R-HSA-211000 | Gene Silencing by RNA | 0.394657 | 0.404 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.402445 | 0.395 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.402645 | 0.395 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.402645 | 0.395 |
| R-HSA-2262752 | Cellular responses to stress | 0.408869 | 0.388 |
| R-HSA-201556 | Signaling by ALK | 0.409254 | 0.388 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.415985 | 0.381 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.415985 | 0.381 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.415985 | 0.381 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.415985 | 0.381 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.415985 | 0.381 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.422639 | 0.374 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.422639 | 0.374 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.422639 | 0.374 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.422639 | 0.374 |
| R-HSA-5617833 | Cilium Assembly | 0.427848 | 0.369 |
| R-HSA-167161 | HIV Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.429219 | 0.367 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.429219 | 0.367 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.434082 | 0.362 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.434082 | 0.362 |
| R-HSA-165159 | MTOR signalling | 0.435724 | 0.361 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.435724 | 0.361 |
| R-HSA-68877 | Mitotic Prometaphase | 0.436862 | 0.360 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.439854 | 0.357 |
| R-HSA-70326 | Glucose metabolism | 0.441804 | 0.355 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.441804 | 0.355 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.442155 | 0.354 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.445643 | 0.351 |
| R-HSA-168256 | Immune System | 0.446309 | 0.350 |
| R-HSA-1280218 | Adaptive Immune System | 0.446704 | 0.350 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.448513 | 0.348 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.448513 | 0.348 |
| R-HSA-69236 | G1 Phase | 0.448513 | 0.348 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.448513 | 0.348 |
| R-HSA-2172127 | DAP12 interactions | 0.448513 | 0.348 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.454799 | 0.342 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.454799 | 0.342 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.454799 | 0.342 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.457073 | 0.340 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.461014 | 0.336 |
| R-HSA-9675135 | Diseases of DNA repair | 0.461014 | 0.336 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.461014 | 0.336 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.463749 | 0.334 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.467158 | 0.331 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.467158 | 0.331 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.468367 | 0.329 |
| R-HSA-72172 | mRNA Splicing | 0.472355 | 0.326 |
| R-HSA-425410 | Metal ion SLC transporters | 0.473232 | 0.325 |
| R-HSA-5357801 | Programmed Cell Death | 0.475268 | 0.323 |
| R-HSA-69206 | G1/S Transition | 0.475819 | 0.323 |
| R-HSA-194138 | Signaling by VEGF | 0.475819 | 0.323 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.476217 | 0.322 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.479238 | 0.319 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.479238 | 0.319 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.479238 | 0.319 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.479238 | 0.319 |
| R-HSA-109704 | PI3K Cascade | 0.485176 | 0.314 |
| R-HSA-9748787 | Azathioprine ADME | 0.485176 | 0.314 |
| R-HSA-912446 | Meiotic recombination | 0.491046 | 0.309 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.491281 | 0.309 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.496850 | 0.304 |
| R-HSA-72187 | mRNA 3'-end processing | 0.496850 | 0.304 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.496850 | 0.304 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.496850 | 0.304 |
| R-HSA-9843745 | Adipogenesis | 0.501396 | 0.300 |
| R-HSA-5576891 | Cardiac conduction | 0.501396 | 0.300 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.502588 | 0.299 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.502588 | 0.299 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.502588 | 0.299 |
| R-HSA-9909396 | Circadian clock | 0.504984 | 0.297 |
| R-HSA-68882 | Mitotic Anaphase | 0.506813 | 0.295 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.508261 | 0.294 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.509633 | 0.293 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.513869 | 0.289 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.513869 | 0.289 |
| R-HSA-418597 | G alpha (z) signalling events | 0.513869 | 0.289 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.513869 | 0.289 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.513869 | 0.289 |
| R-HSA-8953854 | Metabolism of RNA | 0.517120 | 0.286 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.519414 | 0.284 |
| R-HSA-5578775 | Ion homeostasis | 0.519414 | 0.284 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.519414 | 0.284 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.519414 | 0.284 |
| R-HSA-112399 | IRS-mediated signalling | 0.524896 | 0.280 |
| R-HSA-9033241 | Peroxisomal protein import | 0.535674 | 0.271 |
| R-HSA-162906 | HIV Infection | 0.537358 | 0.270 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.540082 | 0.268 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.540972 | 0.267 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.540972 | 0.267 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.540972 | 0.267 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.540972 | 0.267 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.540972 | 0.267 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.546209 | 0.263 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.546209 | 0.263 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.546725 | 0.262 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.550091 | 0.260 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.551387 | 0.259 |
| R-HSA-186797 | Signaling by PDGF | 0.551387 | 0.259 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.556506 | 0.255 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.556506 | 0.255 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.556506 | 0.255 |
| R-HSA-373755 | Semaphorin interactions | 0.556506 | 0.255 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.560086 | 0.252 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.561567 | 0.251 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.561567 | 0.251 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.561567 | 0.251 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.566571 | 0.247 |
| R-HSA-9758941 | Gastrulation | 0.569921 | 0.244 |
| R-HSA-1474244 | Extracellular matrix organization | 0.570786 | 0.244 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.571518 | 0.243 |
| R-HSA-157118 | Signaling by NOTCH | 0.572041 | 0.243 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.573165 | 0.242 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.576408 | 0.239 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.579598 | 0.237 |
| R-HSA-167172 | Transcription of the HIV genome | 0.581243 | 0.236 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.585961 | 0.232 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.589116 | 0.230 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.589623 | 0.229 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.590750 | 0.229 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.590750 | 0.229 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.590750 | 0.229 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.590750 | 0.229 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.595422 | 0.225 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.595422 | 0.225 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.595422 | 0.225 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.598473 | 0.223 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.600041 | 0.222 |
| R-HSA-421270 | Cell-cell junction organization | 0.600111 | 0.222 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.604608 | 0.219 |
| R-HSA-4086398 | Ca2+ pathway | 0.604608 | 0.219 |
| R-HSA-9749641 | Aspirin ADME | 0.604608 | 0.219 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.604623 | 0.219 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.604623 | 0.219 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.609123 | 0.215 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.609123 | 0.215 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.609123 | 0.215 |
| R-HSA-380287 | Centrosome maturation | 0.613587 | 0.212 |
| R-HSA-8852135 | Protein ubiquitination | 0.613587 | 0.212 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.617999 | 0.209 |
| R-HSA-5619102 | SLC transporter disorders | 0.625587 | 0.204 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.626676 | 0.203 |
| R-HSA-216083 | Integrin cell surface interactions | 0.626676 | 0.203 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.626676 | 0.203 |
| R-HSA-73894 | DNA Repair | 0.633205 | 0.198 |
| R-HSA-6806834 | Signaling by MET | 0.635156 | 0.197 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.635156 | 0.197 |
| R-HSA-72306 | tRNA processing | 0.637178 | 0.196 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.639322 | 0.194 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.645686 | 0.190 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.647518 | 0.189 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.648487 | 0.188 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.651545 | 0.186 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.651545 | 0.186 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.654814 | 0.184 |
| R-HSA-1500620 | Meiosis | 0.655527 | 0.183 |
| R-HSA-168255 | Influenza Infection | 0.662230 | 0.179 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.663355 | 0.178 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.663355 | 0.178 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.663355 | 0.178 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.671006 | 0.173 |
| R-HSA-156902 | Peptide chain elongation | 0.671006 | 0.173 |
| R-HSA-9663891 | Selective autophagy | 0.671006 | 0.173 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.678484 | 0.168 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.682160 | 0.166 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.689386 | 0.162 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.689386 | 0.162 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.692937 | 0.159 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.696449 | 0.157 |
| R-HSA-1483257 | Phospholipid metabolism | 0.699931 | 0.155 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.706744 | 0.151 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.722284 | 0.141 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.723137 | 0.141 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.726305 | 0.139 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.732532 | 0.135 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.732532 | 0.135 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.735593 | 0.133 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.735593 | 0.133 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.735883 | 0.133 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.738618 | 0.132 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.752973 | 0.123 |
| R-HSA-8957322 | Metabolism of steroids | 0.754721 | 0.122 |
| R-HSA-9748784 | Drug ADME | 0.757146 | 0.121 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.758856 | 0.120 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.758856 | 0.120 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.758856 | 0.120 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.761617 | 0.118 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.764347 | 0.117 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.769713 | 0.114 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.772350 | 0.112 |
| R-HSA-168249 | Innate Immune System | 0.777508 | 0.109 |
| R-HSA-422475 | Axon guidance | 0.777643 | 0.109 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.784518 | 0.105 |
| R-HSA-9679506 | SARS-CoV Infections | 0.790393 | 0.102 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.792395 | 0.101 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.795275 | 0.099 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.799451 | 0.097 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.799451 | 0.097 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.799451 | 0.097 |
| R-HSA-114608 | Platelet degranulation | 0.804022 | 0.095 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.806268 | 0.094 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.810684 | 0.091 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.810788 | 0.091 |
| R-HSA-112316 | Neuronal System | 0.812351 | 0.090 |
| R-HSA-1474165 | Reproduction | 0.812855 | 0.090 |
| R-HSA-1266738 | Developmental Biology | 0.813931 | 0.089 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.815000 | 0.089 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.819218 | 0.087 |
| R-HSA-9675108 | Nervous system development | 0.821995 | 0.085 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.827370 | 0.082 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.831307 | 0.080 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.833243 | 0.079 |
| R-HSA-9664407 | Parasite infection | 0.835156 | 0.078 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.835156 | 0.078 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.835156 | 0.078 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.837047 | 0.077 |
| R-HSA-913531 | Interferon Signaling | 0.842570 | 0.074 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.842802 | 0.074 |
| R-HSA-166520 | Signaling by NTRKs | 0.851420 | 0.070 |
| R-HSA-9609507 | Protein localization | 0.859756 | 0.066 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.866088 | 0.062 |
| R-HSA-9711097 | Cellular response to starvation | 0.867626 | 0.062 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.876757 | 0.057 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.884323 | 0.053 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.887402 | 0.052 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.889976 | 0.051 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.889976 | 0.051 |
| R-HSA-611105 | Respiratory electron transport | 0.896159 | 0.048 |
| R-HSA-69275 | G2/M Transition | 0.905340 | 0.043 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.907506 | 0.042 |
| R-HSA-983712 | Ion channel transport | 0.908570 | 0.042 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.911057 | 0.040 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.912708 | 0.040 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.915688 | 0.038 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.922255 | 0.035 |
| R-HSA-418990 | Adherens junctions interactions | 0.935416 | 0.029 |
| R-HSA-449147 | Signaling by Interleukins | 0.939751 | 0.027 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.943154 | 0.025 |
| R-HSA-8939211 | ESR-mediated signaling | 0.948196 | 0.023 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 0.949385 | 0.023 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.950017 | 0.022 |
| R-HSA-597592 | Post-translational protein modification | 0.953388 | 0.021 |
| R-HSA-9824446 | Viral Infection Pathways | 0.954990 | 0.020 |
| R-HSA-416476 | G alpha (q) signalling events | 0.962148 | 0.017 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.968942 | 0.014 |
| R-HSA-9658195 | Leishmania infection | 0.968942 | 0.014 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.971705 | 0.012 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.973922 | 0.011 |
| R-HSA-388396 | GPCR downstream signalling | 0.982091 | 0.008 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.984577 | 0.007 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.985622 | 0.006 |
| R-HSA-372790 | Signaling by GPCR | 0.991281 | 0.004 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.992088 | 0.003 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.994100 | 0.003 |
| R-HSA-72766 | Translation | 0.994566 | 0.002 |
| R-HSA-5663205 | Infectious disease | 0.995474 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 0.996620 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.998206 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999419 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999708 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999903 | 0.000 |
| R-HSA-1643685 | Disease | 0.999934 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.873 | 0.138 | 2 | 0.744 |
CLK3 |
0.868 | 0.238 | 1 | 0.845 |
CDC7 |
0.867 | 0.184 | 1 | 0.866 |
PIM3 |
0.866 | 0.190 | -3 | 0.844 |
MOS |
0.864 | 0.205 | 1 | 0.872 |
GRK1 |
0.864 | 0.253 | -2 | 0.821 |
KIS |
0.863 | 0.195 | 1 | 0.711 |
IKKB |
0.861 | 0.068 | -2 | 0.729 |
NDR2 |
0.860 | 0.112 | -3 | 0.841 |
MTOR |
0.860 | 0.061 | 1 | 0.816 |
HIPK4 |
0.856 | 0.198 | 1 | 0.793 |
RSK2 |
0.856 | 0.168 | -3 | 0.764 |
SKMLCK |
0.855 | 0.152 | -2 | 0.872 |
PRPK |
0.855 | -0.044 | -1 | 0.864 |
RAF1 |
0.855 | 0.033 | 1 | 0.861 |
NLK |
0.854 | 0.078 | 1 | 0.852 |
PRKD1 |
0.853 | 0.160 | -3 | 0.801 |
CDKL1 |
0.853 | 0.110 | -3 | 0.796 |
TBK1 |
0.852 | -0.006 | 1 | 0.765 |
ATR |
0.852 | 0.069 | 1 | 0.832 |
CAMK1B |
0.852 | 0.062 | -3 | 0.830 |
PIM1 |
0.852 | 0.170 | -3 | 0.800 |
IKKA |
0.850 | 0.073 | -2 | 0.723 |
GRK5 |
0.850 | 0.048 | -3 | 0.850 |
GRK7 |
0.850 | 0.239 | 1 | 0.811 |
ERK5 |
0.849 | 0.049 | 1 | 0.806 |
P90RSK |
0.849 | 0.129 | -3 | 0.766 |
GRK6 |
0.849 | 0.131 | 1 | 0.872 |
IKKE |
0.849 | -0.019 | 1 | 0.762 |
PRKD2 |
0.849 | 0.143 | -3 | 0.756 |
BMPR1B |
0.848 | 0.197 | 1 | 0.847 |
NDR1 |
0.848 | 0.056 | -3 | 0.823 |
SRPK1 |
0.848 | 0.124 | -3 | 0.757 |
NUAK2 |
0.847 | 0.060 | -3 | 0.826 |
CDKL5 |
0.847 | 0.101 | -3 | 0.785 |
DSTYK |
0.847 | -0.062 | 2 | 0.754 |
DAPK2 |
0.846 | 0.119 | -3 | 0.834 |
AURC |
0.846 | 0.149 | -2 | 0.685 |
BMPR2 |
0.846 | -0.109 | -2 | 0.848 |
PDHK4 |
0.846 | -0.210 | 1 | 0.864 |
MAPKAPK2 |
0.846 | 0.135 | -3 | 0.743 |
CAMK2G |
0.846 | -0.066 | 2 | 0.675 |
CAMLCK |
0.846 | 0.088 | -2 | 0.848 |
PKACG |
0.845 | 0.101 | -2 | 0.753 |
CK1E |
0.845 | 0.215 | -3 | 0.694 |
CHAK2 |
0.845 | 0.077 | -1 | 0.833 |
ICK |
0.845 | 0.130 | -3 | 0.826 |
RSK3 |
0.845 | 0.102 | -3 | 0.753 |
PKN3 |
0.845 | 0.024 | -3 | 0.805 |
RSK4 |
0.845 | 0.179 | -3 | 0.754 |
DYRK2 |
0.845 | 0.132 | 1 | 0.728 |
RIPK3 |
0.845 | -0.032 | 3 | 0.733 |
AMPKA1 |
0.844 | 0.081 | -3 | 0.831 |
HUNK |
0.844 | -0.053 | 2 | 0.704 |
PKN2 |
0.843 | 0.030 | -3 | 0.815 |
LATS2 |
0.843 | 0.047 | -5 | 0.751 |
NIK |
0.843 | -0.003 | -3 | 0.844 |
FAM20C |
0.843 | 0.083 | 2 | 0.559 |
GRK4 |
0.843 | 0.020 | -2 | 0.836 |
TGFBR2 |
0.842 | -0.035 | -2 | 0.760 |
MAPKAPK3 |
0.842 | 0.075 | -3 | 0.767 |
MST4 |
0.842 | 0.025 | 2 | 0.739 |
GCN2 |
0.842 | -0.221 | 2 | 0.666 |
MLK1 |
0.842 | -0.070 | 2 | 0.697 |
P70S6KB |
0.842 | 0.086 | -3 | 0.780 |
HIPK2 |
0.842 | 0.179 | 1 | 0.642 |
CLK2 |
0.842 | 0.200 | -3 | 0.759 |
WNK1 |
0.841 | -0.036 | -2 | 0.865 |
PKACB |
0.840 | 0.155 | -2 | 0.698 |
LATS1 |
0.840 | 0.155 | -3 | 0.845 |
SRPK2 |
0.840 | 0.107 | -3 | 0.692 |
ULK2 |
0.839 | -0.214 | 2 | 0.677 |
MARK4 |
0.839 | -0.019 | 4 | 0.849 |
CDK8 |
0.839 | 0.060 | 1 | 0.703 |
PKCD |
0.839 | 0.045 | 2 | 0.677 |
AMPKA2 |
0.839 | 0.080 | -3 | 0.805 |
HIPK1 |
0.839 | 0.173 | 1 | 0.738 |
CAMK2B |
0.838 | 0.066 | 2 | 0.637 |
PAK1 |
0.838 | 0.063 | -2 | 0.804 |
CK1D |
0.838 | 0.229 | -3 | 0.652 |
DLK |
0.838 | -0.034 | 1 | 0.843 |
TTBK2 |
0.837 | -0.075 | 2 | 0.601 |
CLK4 |
0.837 | 0.137 | -3 | 0.764 |
MSK2 |
0.837 | 0.068 | -3 | 0.758 |
NEK6 |
0.837 | -0.095 | -2 | 0.824 |
MSK1 |
0.837 | 0.120 | -3 | 0.754 |
CAMK2D |
0.837 | -0.014 | -3 | 0.808 |
SRPK3 |
0.837 | 0.082 | -3 | 0.739 |
CDK19 |
0.837 | 0.075 | 1 | 0.668 |
PRKX |
0.836 | 0.168 | -3 | 0.700 |
ALK4 |
0.836 | 0.049 | -2 | 0.787 |
NEK7 |
0.836 | -0.172 | -3 | 0.818 |
PDHK1 |
0.836 | -0.223 | 1 | 0.843 |
TSSK2 |
0.836 | 0.017 | -5 | 0.828 |
TGFBR1 |
0.836 | 0.059 | -2 | 0.763 |
MASTL |
0.836 | -0.165 | -2 | 0.791 |
JNK2 |
0.836 | 0.120 | 1 | 0.663 |
CDK7 |
0.835 | 0.077 | 1 | 0.710 |
CDK18 |
0.835 | 0.114 | 1 | 0.645 |
JNK3 |
0.835 | 0.101 | 1 | 0.693 |
CAMK2A |
0.835 | 0.062 | 2 | 0.657 |
AURB |
0.834 | 0.108 | -2 | 0.683 |
TSSK1 |
0.834 | 0.033 | -3 | 0.841 |
PLK1 |
0.834 | 0.003 | -2 | 0.788 |
ATM |
0.834 | 0.005 | 1 | 0.782 |
CDK1 |
0.834 | 0.095 | 1 | 0.683 |
MYLK4 |
0.833 | 0.086 | -2 | 0.791 |
GRK2 |
0.833 | 0.073 | -2 | 0.723 |
PAK3 |
0.833 | 0.018 | -2 | 0.793 |
CK1A2 |
0.833 | 0.201 | -3 | 0.654 |
PKG2 |
0.833 | 0.096 | -2 | 0.690 |
CK1G1 |
0.833 | 0.153 | -3 | 0.682 |
CAMK4 |
0.832 | -0.026 | -3 | 0.800 |
ACVR2B |
0.832 | 0.083 | -2 | 0.759 |
PKCG |
0.832 | 0.016 | 2 | 0.637 |
SGK3 |
0.832 | 0.107 | -3 | 0.755 |
CLK1 |
0.832 | 0.122 | -3 | 0.727 |
WNK3 |
0.832 | -0.207 | 1 | 0.815 |
AURA |
0.832 | 0.097 | -2 | 0.671 |
DYRK4 |
0.832 | 0.126 | 1 | 0.660 |
NIM1 |
0.832 | -0.057 | 3 | 0.782 |
ACVR2A |
0.831 | 0.061 | -2 | 0.740 |
RIPK1 |
0.831 | -0.134 | 1 | 0.798 |
BCKDK |
0.831 | -0.164 | -1 | 0.761 |
PKCA |
0.831 | 0.036 | 2 | 0.630 |
PKCB |
0.831 | 0.010 | 2 | 0.633 |
DYRK1A |
0.831 | 0.127 | 1 | 0.756 |
MLK3 |
0.831 | -0.052 | 2 | 0.639 |
MLK2 |
0.830 | -0.111 | 2 | 0.707 |
PAK2 |
0.830 | 0.036 | -2 | 0.785 |
PIM2 |
0.830 | 0.136 | -3 | 0.737 |
P38B |
0.829 | 0.108 | 1 | 0.667 |
P38A |
0.829 | 0.086 | 1 | 0.729 |
PRKD3 |
0.829 | 0.059 | -3 | 0.725 |
ERK1 |
0.829 | 0.084 | 1 | 0.658 |
AKT2 |
0.828 | 0.107 | -3 | 0.693 |
P38G |
0.828 | 0.088 | 1 | 0.595 |
BMPR1A |
0.828 | 0.122 | 1 | 0.826 |
ALK2 |
0.828 | 0.050 | -2 | 0.775 |
ANKRD3 |
0.828 | -0.159 | 1 | 0.850 |
ULK1 |
0.828 | -0.250 | -3 | 0.763 |
QSK |
0.828 | 0.024 | 4 | 0.827 |
DYRK1B |
0.827 | 0.122 | 1 | 0.695 |
NEK9 |
0.827 | -0.196 | 2 | 0.708 |
PASK |
0.827 | 0.147 | -3 | 0.861 |
IRE1 |
0.827 | -0.118 | 1 | 0.765 |
MNK2 |
0.827 | 0.003 | -2 | 0.797 |
MNK1 |
0.827 | 0.031 | -2 | 0.805 |
MEK1 |
0.826 | -0.084 | 2 | 0.736 |
CDK5 |
0.826 | 0.058 | 1 | 0.729 |
NUAK1 |
0.826 | -0.001 | -3 | 0.772 |
GRK3 |
0.826 | 0.093 | -2 | 0.692 |
CDK17 |
0.825 | 0.079 | 1 | 0.603 |
HIPK3 |
0.825 | 0.112 | 1 | 0.733 |
MLK4 |
0.825 | -0.075 | 2 | 0.617 |
DNAPK |
0.825 | 0.038 | 1 | 0.742 |
BRSK1 |
0.824 | -0.013 | -3 | 0.777 |
CDK14 |
0.824 | 0.102 | 1 | 0.692 |
SMG1 |
0.824 | -0.021 | 1 | 0.781 |
VRK2 |
0.824 | -0.154 | 1 | 0.861 |
PKR |
0.824 | -0.069 | 1 | 0.822 |
TLK2 |
0.824 | -0.041 | 1 | 0.811 |
DRAK1 |
0.824 | -0.005 | 1 | 0.817 |
YSK4 |
0.824 | -0.092 | 1 | 0.788 |
DYRK3 |
0.824 | 0.128 | 1 | 0.736 |
PLK3 |
0.824 | -0.049 | 2 | 0.656 |
PHKG1 |
0.823 | -0.052 | -3 | 0.815 |
MELK |
0.823 | -0.041 | -3 | 0.778 |
PAK6 |
0.823 | 0.042 | -2 | 0.712 |
PKCH |
0.823 | -0.033 | 2 | 0.620 |
QIK |
0.823 | -0.090 | -3 | 0.803 |
CDK13 |
0.822 | 0.016 | 1 | 0.685 |
ERK2 |
0.822 | 0.035 | 1 | 0.701 |
SIK |
0.822 | 0.002 | -3 | 0.752 |
PKCZ |
0.822 | -0.047 | 2 | 0.672 |
P38D |
0.822 | 0.115 | 1 | 0.600 |
PKACA |
0.821 | 0.113 | -2 | 0.644 |
MARK3 |
0.821 | -0.013 | 4 | 0.770 |
MST3 |
0.820 | 0.051 | 2 | 0.733 |
CHAK1 |
0.820 | -0.104 | 2 | 0.708 |
DCAMKL1 |
0.820 | 0.011 | -3 | 0.776 |
PLK4 |
0.819 | -0.091 | 2 | 0.554 |
MEKK3 |
0.819 | -0.060 | 1 | 0.813 |
MPSK1 |
0.818 | 0.126 | 1 | 0.767 |
CDK3 |
0.818 | 0.076 | 1 | 0.619 |
NEK2 |
0.818 | -0.122 | 2 | 0.705 |
DAPK3 |
0.818 | 0.126 | -3 | 0.796 |
IRE2 |
0.818 | -0.122 | 2 | 0.650 |
CDK12 |
0.818 | 0.026 | 1 | 0.660 |
PRP4 |
0.818 | 0.009 | -3 | 0.709 |
CAMK1G |
0.817 | -0.011 | -3 | 0.749 |
MARK2 |
0.817 | -0.046 | 4 | 0.740 |
AKT1 |
0.817 | 0.097 | -3 | 0.710 |
CDK16 |
0.817 | 0.086 | 1 | 0.619 |
MAK |
0.817 | 0.191 | -2 | 0.778 |
CDK10 |
0.817 | 0.092 | 1 | 0.676 |
BRSK2 |
0.816 | -0.085 | -3 | 0.785 |
GAK |
0.816 | 0.111 | 1 | 0.845 |
DAPK1 |
0.816 | 0.127 | -3 | 0.782 |
CK2A2 |
0.815 | 0.163 | 1 | 0.741 |
CDK2 |
0.815 | -0.024 | 1 | 0.766 |
SMMLCK |
0.815 | 0.039 | -3 | 0.791 |
MAPKAPK5 |
0.815 | -0.067 | -3 | 0.721 |
CHK1 |
0.815 | -0.037 | -3 | 0.796 |
SNRK |
0.814 | -0.168 | 2 | 0.604 |
CDK9 |
0.814 | -0.003 | 1 | 0.691 |
P70S6K |
0.814 | 0.059 | -3 | 0.698 |
MEK5 |
0.814 | -0.181 | 2 | 0.715 |
JNK1 |
0.814 | 0.073 | 1 | 0.658 |
MARK1 |
0.813 | -0.061 | 4 | 0.800 |
TLK1 |
0.813 | -0.087 | -2 | 0.811 |
TAO3 |
0.813 | -0.012 | 1 | 0.804 |
SSTK |
0.812 | -0.018 | 4 | 0.831 |
NEK5 |
0.812 | -0.110 | 1 | 0.821 |
SGK1 |
0.812 | 0.129 | -3 | 0.632 |
MEKK2 |
0.811 | -0.109 | 2 | 0.683 |
BRAF |
0.811 | -0.133 | -4 | 0.829 |
WNK4 |
0.810 | -0.130 | -2 | 0.843 |
ZAK |
0.810 | -0.156 | 1 | 0.778 |
PKCT |
0.810 | -0.028 | 2 | 0.624 |
NEK11 |
0.809 | -0.072 | 1 | 0.809 |
CAMK1D |
0.809 | 0.040 | -3 | 0.688 |
TTBK1 |
0.809 | -0.138 | 2 | 0.540 |
GCK |
0.809 | 0.081 | 1 | 0.842 |
GSK3A |
0.809 | 0.038 | 4 | 0.454 |
MEKK1 |
0.809 | -0.178 | 1 | 0.806 |
PERK |
0.809 | -0.189 | -2 | 0.791 |
CK1A |
0.809 | 0.188 | -3 | 0.580 |
DCAMKL2 |
0.808 | -0.058 | -3 | 0.781 |
IRAK4 |
0.808 | -0.135 | 1 | 0.767 |
ROCK2 |
0.807 | 0.128 | -3 | 0.780 |
CK2A1 |
0.807 | 0.148 | 1 | 0.722 |
PKCE |
0.807 | 0.024 | 2 | 0.630 |
PAK5 |
0.806 | 0.024 | -2 | 0.658 |
LKB1 |
0.806 | -0.002 | -3 | 0.794 |
PDK1 |
0.806 | -0.038 | 1 | 0.791 |
AKT3 |
0.805 | 0.100 | -3 | 0.648 |
MOK |
0.805 | 0.145 | 1 | 0.736 |
GSK3B |
0.805 | -0.010 | 4 | 0.447 |
ERK7 |
0.805 | -0.017 | 2 | 0.463 |
PINK1 |
0.804 | -0.182 | 1 | 0.814 |
MRCKA |
0.804 | 0.099 | -3 | 0.745 |
PAK4 |
0.804 | 0.026 | -2 | 0.672 |
PLK2 |
0.804 | -0.013 | -3 | 0.754 |
HPK1 |
0.803 | 0.058 | 1 | 0.823 |
NEK8 |
0.803 | -0.164 | 2 | 0.708 |
HRI |
0.802 | -0.267 | -2 | 0.798 |
PHKG2 |
0.802 | -0.086 | -3 | 0.758 |
MRCKB |
0.802 | 0.087 | -3 | 0.724 |
PKCI |
0.802 | -0.050 | 2 | 0.645 |
MST2 |
0.801 | -0.067 | 1 | 0.835 |
MAP3K15 |
0.800 | -0.061 | 1 | 0.764 |
TAK1 |
0.800 | -0.035 | 1 | 0.841 |
CHK2 |
0.799 | 0.044 | -3 | 0.637 |
MEKK6 |
0.799 | -0.096 | 1 | 0.796 |
TNIK |
0.799 | 0.003 | 3 | 0.831 |
CAMKK1 |
0.799 | -0.179 | -2 | 0.725 |
TAO2 |
0.799 | -0.127 | 2 | 0.733 |
MINK |
0.799 | -0.010 | 1 | 0.808 |
BUB1 |
0.798 | 0.118 | -5 | 0.796 |
NEK4 |
0.797 | -0.103 | 1 | 0.791 |
KHS2 |
0.797 | 0.070 | 1 | 0.825 |
CAMKK2 |
0.797 | -0.136 | -2 | 0.717 |
KHS1 |
0.797 | 0.054 | 1 | 0.805 |
CDK6 |
0.797 | 0.019 | 1 | 0.664 |
PKN1 |
0.796 | -0.015 | -3 | 0.709 |
EEF2K |
0.796 | -0.094 | 3 | 0.804 |
IRAK1 |
0.796 | -0.266 | -1 | 0.752 |
DMPK1 |
0.796 | 0.120 | -3 | 0.748 |
VRK1 |
0.795 | -0.135 | 2 | 0.724 |
PDHK3_TYR |
0.795 | 0.241 | 4 | 0.934 |
HGK |
0.795 | -0.061 | 3 | 0.824 |
CDK4 |
0.794 | 0.022 | 1 | 0.648 |
CAMK1A |
0.794 | 0.030 | -3 | 0.655 |
YANK3 |
0.794 | -0.001 | 2 | 0.357 |
LRRK2 |
0.793 | -0.156 | 2 | 0.731 |
MST1 |
0.793 | -0.072 | 1 | 0.810 |
PBK |
0.792 | 0.034 | 1 | 0.765 |
LOK |
0.792 | -0.068 | -2 | 0.740 |
CRIK |
0.792 | 0.132 | -3 | 0.712 |
SBK |
0.791 | 0.066 | -3 | 0.584 |
PDHK4_TYR |
0.791 | 0.187 | 2 | 0.765 |
NEK1 |
0.791 | -0.115 | 1 | 0.788 |
SLK |
0.791 | -0.075 | -2 | 0.688 |
ROCK1 |
0.790 | 0.086 | -3 | 0.742 |
MAP2K6_TYR |
0.788 | 0.118 | -1 | 0.867 |
STK33 |
0.788 | -0.172 | 2 | 0.541 |
PKG1 |
0.787 | 0.027 | -2 | 0.607 |
MAP2K4_TYR |
0.787 | 0.106 | -1 | 0.871 |
TTK |
0.787 | 0.000 | -2 | 0.805 |
PDHK1_TYR |
0.786 | 0.103 | -1 | 0.875 |
BMPR2_TYR |
0.784 | 0.060 | -1 | 0.860 |
TESK1_TYR |
0.784 | 0.007 | 3 | 0.880 |
ALPHAK3 |
0.783 | 0.012 | -1 | 0.767 |
YSK1 |
0.783 | -0.128 | 2 | 0.689 |
OSR1 |
0.783 | -0.074 | 2 | 0.689 |
MAP2K7_TYR |
0.782 | -0.090 | 2 | 0.745 |
PKMYT1_TYR |
0.781 | 0.002 | 3 | 0.845 |
MEK2 |
0.781 | -0.262 | 2 | 0.703 |
CK1G3 |
0.781 | 0.151 | -3 | 0.539 |
HASPIN |
0.781 | -0.014 | -1 | 0.717 |
RIPK2 |
0.779 | -0.289 | 1 | 0.733 |
LIMK2_TYR |
0.778 | 0.037 | -3 | 0.838 |
TXK |
0.777 | 0.107 | 1 | 0.859 |
PINK1_TYR |
0.777 | -0.139 | 1 | 0.832 |
YES1 |
0.775 | 0.020 | -1 | 0.864 |
FGR |
0.775 | 0.037 | 1 | 0.855 |
ASK1 |
0.774 | -0.135 | 1 | 0.749 |
RET |
0.774 | -0.067 | 1 | 0.798 |
ABL2 |
0.774 | 0.021 | -1 | 0.807 |
BIKE |
0.774 | 0.006 | 1 | 0.727 |
EPHB4 |
0.774 | -0.019 | -1 | 0.804 |
EPHA6 |
0.773 | -0.023 | -1 | 0.830 |
ROS1 |
0.771 | -0.053 | 3 | 0.754 |
MYO3B |
0.771 | -0.091 | 2 | 0.724 |
FER |
0.771 | -0.043 | 1 | 0.881 |
LCK |
0.771 | 0.066 | -1 | 0.843 |
MYO3A |
0.770 | -0.091 | 1 | 0.787 |
TYRO3 |
0.770 | -0.115 | 3 | 0.777 |
ABL1 |
0.770 | -0.009 | -1 | 0.804 |
TNK2 |
0.770 | 0.010 | 3 | 0.749 |
CSF1R |
0.770 | -0.066 | 3 | 0.768 |
BLK |
0.770 | 0.073 | -1 | 0.839 |
MST1R |
0.769 | -0.128 | 3 | 0.793 |
NEK3 |
0.769 | -0.227 | 1 | 0.744 |
TYK2 |
0.769 | -0.132 | 1 | 0.797 |
FYN |
0.768 | 0.077 | -1 | 0.835 |
HCK |
0.768 | -0.020 | -1 | 0.840 |
SRMS |
0.768 | -0.026 | 1 | 0.870 |
LIMK1_TYR |
0.768 | -0.185 | 2 | 0.744 |
INSRR |
0.767 | -0.043 | 3 | 0.740 |
JAK2 |
0.767 | -0.116 | 1 | 0.790 |
ITK |
0.766 | -0.032 | -1 | 0.804 |
MERTK |
0.765 | -0.029 | 3 | 0.775 |
EPHA4 |
0.764 | -0.055 | 2 | 0.672 |
BMX |
0.764 | -0.003 | -1 | 0.737 |
DDR1 |
0.763 | -0.176 | 4 | 0.859 |
TAO1 |
0.763 | -0.159 | 1 | 0.728 |
JAK3 |
0.763 | -0.110 | 1 | 0.779 |
EPHB1 |
0.763 | -0.069 | 1 | 0.859 |
KIT |
0.763 | -0.079 | 3 | 0.771 |
MET |
0.763 | -0.030 | 3 | 0.770 |
CK1G2 |
0.762 | 0.114 | -3 | 0.616 |
KDR |
0.762 | -0.082 | 3 | 0.742 |
YANK2 |
0.761 | -0.022 | 2 | 0.367 |
STLK3 |
0.761 | -0.182 | 1 | 0.748 |
EPHB2 |
0.761 | -0.056 | -1 | 0.780 |
JAK1 |
0.761 | 0.008 | 1 | 0.751 |
AAK1 |
0.761 | 0.063 | 1 | 0.624 |
EPHB3 |
0.760 | -0.090 | -1 | 0.784 |
FGFR2 |
0.760 | -0.152 | 3 | 0.793 |
AXL |
0.758 | -0.109 | 3 | 0.768 |
TEC |
0.758 | -0.062 | -1 | 0.748 |
TNK1 |
0.758 | -0.089 | 3 | 0.762 |
FLT3 |
0.757 | -0.152 | 3 | 0.769 |
PDGFRB |
0.755 | -0.193 | 3 | 0.782 |
TEK |
0.755 | -0.163 | 3 | 0.723 |
SYK |
0.755 | 0.088 | -1 | 0.759 |
SRC |
0.755 | -0.010 | -1 | 0.830 |
PTK2 |
0.755 | 0.059 | -1 | 0.776 |
NEK10_TYR |
0.755 | -0.078 | 1 | 0.675 |
ALK |
0.755 | -0.106 | 3 | 0.705 |
BTK |
0.754 | -0.169 | -1 | 0.776 |
PTK2B |
0.754 | -0.033 | -1 | 0.781 |
FLT1 |
0.753 | -0.097 | -1 | 0.803 |
ERBB2 |
0.753 | -0.117 | 1 | 0.786 |
EPHA7 |
0.753 | -0.084 | 2 | 0.672 |
LYN |
0.752 | -0.061 | 3 | 0.696 |
PTK6 |
0.752 | -0.151 | -1 | 0.744 |
FGFR1 |
0.752 | -0.190 | 3 | 0.762 |
FRK |
0.752 | -0.093 | -1 | 0.827 |
FGFR3 |
0.752 | -0.135 | 3 | 0.764 |
LTK |
0.751 | -0.140 | 3 | 0.732 |
TNNI3K_TYR |
0.751 | -0.112 | 1 | 0.780 |
WEE1_TYR |
0.751 | -0.124 | -1 | 0.753 |
NTRK1 |
0.750 | -0.182 | -1 | 0.799 |
EPHA3 |
0.750 | -0.143 | 2 | 0.644 |
PDGFRA |
0.748 | -0.235 | 3 | 0.777 |
MATK |
0.748 | -0.099 | -1 | 0.728 |
EGFR |
0.748 | -0.060 | 1 | 0.697 |
EPHA1 |
0.748 | -0.135 | 3 | 0.748 |
INSR |
0.748 | -0.153 | 3 | 0.712 |
DDR2 |
0.747 | -0.065 | 3 | 0.727 |
EPHA5 |
0.747 | -0.090 | 2 | 0.653 |
NTRK3 |
0.746 | -0.129 | -1 | 0.754 |
EPHA8 |
0.745 | -0.083 | -1 | 0.775 |
FLT4 |
0.743 | -0.213 | 3 | 0.743 |
FGFR4 |
0.743 | -0.092 | -1 | 0.754 |
NTRK2 |
0.742 | -0.228 | 3 | 0.742 |
CSK |
0.741 | -0.156 | 2 | 0.676 |
ERBB4 |
0.741 | -0.015 | 1 | 0.734 |
ZAP70 |
0.739 | 0.055 | -1 | 0.697 |
IGF1R |
0.736 | -0.123 | 3 | 0.658 |
EPHA2 |
0.736 | -0.097 | -1 | 0.743 |
FES |
0.729 | -0.093 | -1 | 0.718 |
MUSK |
0.724 | -0.192 | 1 | 0.686 |