Motif 177 (n=305)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | S2971 | ochoa | Snf2 related CREBBP activator protein | None |
| A6NIX2 | WTIP | S171 | ochoa | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| A6NKF1 | SAC3D1 | S41 | ochoa | SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1) | Involved in centrosome duplication and mitotic progression. {ECO:0000250}. |
| E9PAV3 | NACA | S855 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| O14686 | KMT2D | S1854 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15047 | SETD1A | S459 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15047 | SETD1A | S1103 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15047 | SETD1A | S1114 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15117 | FYB1 | S214 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O43426 | SYNJ1 | S1073 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43439 | CBFA2T2 | S44 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O43516 | WIPF1 | S203 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O60245 | PCDH7 | S1000 | ochoa | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
| O60307 | MAST3 | S146 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O75044 | SRGAP2 | S994 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75161 | NPHP4 | S510 | ochoa | Nephrocystin-4 (Nephroretinin) | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may down-regulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as a negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462). {ECO:0000250|UniProtKB:B0DOB4, ECO:0000250|UniProtKB:P59240, ECO:0000269|PubMed:21498478, ECO:0000269|PubMed:21555462, ECO:0000269|PubMed:21565611, ECO:0000269|PubMed:22654112, ECO:0000305|PubMed:19755384}. |
| O75381 | PEX14 | S249 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75385 | ULK1 | S522 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75385 | ULK1 | S533 | ochoa|psp | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75909 | CCNK | S329 | ochoa | Cyclin-K | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). {ECO:0000269|PubMed:10574912, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:9632813}. |
| O94804 | STK10 | S392 | ochoa | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}. |
| O94887 | FARP2 | S399 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O94887 | FARP2 | S480 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95503 | CBX6 | S280 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
| O95785 | WIZ | S1006 | ochoa | Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803) | May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}. |
| P11277 | SPTB | S2114 | ochoa|psp | Spectrin beta chain, erythrocytic (Beta-I spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P11940 | PABPC1 | S434 | ochoa | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| P13994 | YJU2B | S332 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P13994 | YJU2B | S362 | ochoa | Probable splicing factor YJU2B (Coiled-coil domain-containing protein 130) | May be involved in mRNA splicing. {ECO:0000250|UniProtKB:Q9BW85}. |
| P17600 | SYN1 | S427 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P18858 | LIG1 | S98 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P19634 | SLC9A1 | S693 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P19634 | SLC9A1 | S785 | ochoa|psp | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
| P22670 | RFX1 | S193 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P27816 | MAP4 | S896 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30305 | CDC25B | S238 | ochoa | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P40337 | VHL | S80 | ochoa|psp | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272). {ECO:0000269|PubMed:10944113, ECO:0000269|PubMed:17981124, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:34290272}. |
| P42684 | ABL2 | S620 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P43403 | ZAP70 | S301 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P46531 | NOTCH1 | S2513 | psp | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}. |
| P46821 | MAP1B | S1427 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46937 | YAP1 | S138 | ochoa|psp | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}. |
| P53602 | MVD | S222 | ochoa | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000269|PubMed:18823933, ECO:0000269|PubMed:8626466, ECO:0000269|PubMed:9392419}. |
| P53814 | SMTN | S357 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P57682 | KLF3 | S108 | ochoa|psp | Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) | Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity). {ECO:0000250}. |
| P78312 | FAM193A | S666 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78559 | MAP1A | S2074 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | S2124 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P98171 | ARHGAP4 | S831 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| P98174 | FGD1 | S235 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q00613 | HSF1 | S303 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q01484 | ANK2 | S2440 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01804 | OTUD4 | S546 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q03164 | KMT2A | S2151 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04721 | NOTCH2 | S2070 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q04726 | TLE3 | S332 | ochoa | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) | Transcriptional corepressor that binds to a number of transcription factors (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250|UniProtKB:Q04724, ECO:0000269|PubMed:28689657}. |
| Q07889 | SOS1 | S1167 | ochoa|psp | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q07912 | TNK2 | S785 | ochoa | Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) | Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. |
| Q08174 | PCDH1 | S973 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08AD1 | CAMSAP2 | S1276 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q12772 | SREBF2 | S106 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12772 | SREBF2 | S117 | ochoa | Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)] | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}. |
| Q12778 | FOXO1 | S287 | ochoa|psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12873 | CHD3 | S1538 | ochoa | Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}. |
| Q13303 | KCNAB2 | S20 | ochoa | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). {ECO:0000250|UniProtKB:P62482, ECO:0000250|UniProtKB:P62483, ECO:0000269|PubMed:11825900, ECO:0000269|PubMed:7649300}. |
| Q13425 | SNTB2 | S222 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Q13469 | NFATC2 | S330 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q14162 | SCARF1 | S742 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14181 | POLA2 | S141 | ochoa | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}. |
| Q14289 | PTK2B | S747 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14687 | GSE1 | S95 | ochoa | Genetic suppressor element 1 | None |
| Q14896 | MYBPC3 | S133 | psp | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Q15569 | TESK1 | S441 | ochoa | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q15599 | NHERF2 | S261 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15648 | MED1 | S1207 | ochoa|psp | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15652 | JMJD1C | S630 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15652 | JMJD1C | S641 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15797 | SMAD1 | S195 | psp | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16204 | CCDC6 | S395 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16625 | OCLN | S310 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q2KJY2 | KIF26B | S1613 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
| Q4VCS5 | AMOT | S309 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q53ET0 | CRTC2 | S490 | ochoa | CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}. |
| Q53T59 | HS1BP3 | S128 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5SXM2 | SNAPC4 | S1163 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
| Q5SYE7 | NHSL1 | S851 | ochoa | NHS-like protein 1 | None |
| Q5T1M5 | FKBP15 | S311 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5VT52 | RPRD2 | S758 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VWG9 | TAF3 | S229 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q66K74 | MAP1S | S646 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68DC2 | ANKS6 | S688 | ochoa | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | Required for renal function. {ECO:0000269|PubMed:23793029}. |
| Q6JBY9 | RCSD1 | S116 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6P1N0 | CC2D1A | S239 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6P1R3 | MSANTD2 | S24 | ochoa | Myb/SANT-like DNA-binding domain-containing protein 2 | None |
| Q6PJF5 | RHBDF2 | S309 | ochoa | Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Q6ZNJ1 | NBEAL2 | S1301 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRS2 | SRCAP | S3148 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZRV2 | FAM83H | S870 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S881 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S892 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S903 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S914 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S925 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZSY5 | PPP1R3F | S401 | ochoa | Protein phosphatase 1 regulatory subunit 3F (R3F) | Glycogen-targeting subunit for protein phosphatase 1 (PP1). {ECO:0000269|PubMed:21668450}. |
| Q6ZUT6 | CCDC9B | S392 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q6ZW31 | SYDE1 | S244 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70CQ4 | USP31 | S1100 | ochoa | Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2. {ECO:0000269|PubMed:34184746}.; FUNCTION: (Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein. {ECO:0000269|PubMed:35468926}. |
| Q76L83 | ASXL2 | S834 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7L8J4 | SH3BP5L | S30 | ochoa | SH3 domain-binding protein 5-like (SH3BP-5-like) | Functions as a guanine nucleotide exchange factor (GEF) for RAB11A. {ECO:0000269|PubMed:30217979}. |
| Q7Z3K3 | POGZ | S425 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q7Z5J4 | RAI1 | S1122 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z6B7 | SRGAP1 | S999 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q7Z6B7 | SRGAP1 | S1010 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86TC9 | MYPN | S418 | ochoa | Myopalladin (145 kDa sarcomeric protein) | Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269|PubMed:11309420}. |
| Q86XL3 | ANKLE2 | S875 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YW5 | TREML1 | S236 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IY33 | MICALL2 | S649 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IY92 | SLX4 | S1028 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8IYB3 | SRRM1 | S391 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S685 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S696 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZD2 | KMT2E | S1002 | ochoa | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) | Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Q8IZW8 | TNS4 | S253 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N0Y2 | ZNF444 | S232 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8N1G0 | ZNF687 | S129 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8N1I0 | DOCK4 | S1799 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
| Q8N3V7 | SYNPO | S854 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8NAX2 | KDF1 | S179 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
| Q8ND56 | LSM14A | S192 | ochoa | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}. |
| Q8TAP9 | MPLKIP | S93 | ochoa|psp | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TAP9 | MPLKIP | S104 | ochoa|psp | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TEM1 | NUP210 | S1852 | ochoa | Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) | Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}. |
| Q8TEQ0 | SNX29 | S445 | ochoa | Sorting nexin-29 (RUN domain-containing protein 2A) | None |
| Q8TEW8 | PARD3B | S352 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TEW8 | PARD3B | S971 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF44 | C2CD4C | S273 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WUF5 | PPP1R13L | S567 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WXX7 | AUTS2 | S319 | ochoa | Autism susceptibility gene 2 protein | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}. |
| Q93045 | STMN2 | S62 | ochoa|psp | Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10) | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Q96CX2 | KCTD12 | S176 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96CX2 | KCTD12 | S185 | ochoa | BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain) | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}. |
| Q96D71 | REPS1 | S143 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96IF1 | AJUBA | S175 | ochoa|psp | LIM domain-containing protein ajuba | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:12417594, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:15870274, ECO:0000269|PubMed:16413547, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22286099}. |
| Q96JE9 | MAP6 | S519 | ochoa | Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP) | Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}. |
| Q96JM3 | CHAMP1 | S131 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S142 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S164 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S173 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S184 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S244 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S253 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S264 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S275 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S286 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S297 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S308 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S319 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S344 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S355 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S405 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S416 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S436 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S476 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S542 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96KQ4 | PPP1R13B | S478 | ochoa | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540}. |
| Q96PC5 | MIA2 | S1156 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
| Q96PN7 | TRERF1 | S689 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96PN7 | TRERF1 | S1070 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
| Q96QB1 | DLC1 | S566 | ochoa | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96QU8 | XPO6 | S208 | ochoa | Exportin-6 (Exp6) (Ran-binding protein 20) | Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269|PubMed:14592989}. |
| Q96T23 | RSF1 | S1375 | ochoa|psp | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99501 | GAS2L1 | S292 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99958 | FOXC2 | S240 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q99958 | FOXC2 | S251 | psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BQG0 | MYBBP1A | S1232 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BQG0 | MYBBP1A | S1248 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BQI5 | SGIP1 | S482 | ochoa | SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein) | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. {ECO:0000250|UniProtKB:Q8VD37}. |
| Q9BRD0 | BUD13 | S375 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BRD0 | BUD13 | S391 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BT09 | CNPY3 | S257 | ochoa | Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) | Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}. |
| Q9BTC0 | DIDO1 | S1019 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BVC5 | C2orf49 | S182 | ochoa | Ashwin | None |
| Q9BWN1 | PRR14 | S29 | ochoa | Proline-rich protein 14 | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269|PubMed:24209742, ECO:0000269|PubMed:25906157, ECO:0000269|PubMed:27041574}. |
| Q9BZA7 | PCDH11X | S932 | ochoa | Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) | Potential calcium-dependent cell-adhesion protein. |
| Q9BZA7 | PCDH11X | S943 | ochoa | Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S) | Potential calcium-dependent cell-adhesion protein. |
| Q9C073 | FAM117A | S306 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0D5 | TANC1 | S29 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9H211 | CDT1 | S391 | ochoa|psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H4Z3 | PCIF1 | S19 | ochoa | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (EC 2.1.1.62) (Cap-specific adenosine methyltransferase) (CAPAM) (hCAPAM) (Phosphorylated CTD-interacting factor 1) (hPCIF1) (Protein phosphatase 1 regulatory subunit 121) | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178). {ECO:0000269|PubMed:30467178, ECO:0000269|PubMed:30487554, ECO:0000269|PubMed:31279658, ECO:0000269|PubMed:31279659, ECO:0000269|PubMed:33428944}. |
| Q9H5V7 | IKZF5 | S309 | ochoa | Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) | Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (PubMed:10978333, PubMed:31217188). Involved in megakaryocyte differentiation. {ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:31217188}. |
| Q9H6F5 | CCDC86 | S58 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6F5 | CCDC86 | S69 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6F5 | CCDC86 | S80 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6F5 | CCDC86 | S91 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6F5 | CCDC86 | S102 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H7P9 | PLEKHG2 | S911 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9HAU0 | PLEKHA5 | S557 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HC56 | PCDH9 | S932 | ochoa | Protocadherin-9 | Potential calcium-dependent cell-adhesion protein. |
| Q9HC56 | PCDH9 | S943 | ochoa | Protocadherin-9 | Potential calcium-dependent cell-adhesion protein. |
| Q9HCD6 | TANC2 | S129 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCD6 | TANC2 | S1534 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NRA8 | EIF4ENIF1 | S670 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRA8 | EIF4ENIF1 | S681 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRR5 | UBQLN4 | S98 | ochoa | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Q9NTZ6 | RBM12 | S413 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
| Q9NX95 | SYBU | S88 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9NYB9 | ABI2 | S216 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9NYV4 | CDK12 | S265 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9NYV4 | CDK12 | S334 | ochoa | Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12) | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Q9P1Y5 | CAMSAP3 | S769 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P1Y6 | PHRF1 | S1360 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P275 | USP36 | S742 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9UBW5 | BIN2 | S436 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UBW5 | BIN2 | S447 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UBZ9 | REV1 | S1097 | ochoa | DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase) | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. |
| Q9UI08 | EVL | S338 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UI08 | EVL | S349 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UI08 | EVL | S354 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9ULJ3 | ZBTB21 | S177 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
| Q9UMN6 | KMT2B | S560 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMS6 | SYNPO2 | S930 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPT8 | ZC3H4 | S159 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UQ35 | SRRM2 | S351 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S924 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1179 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | S1483 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2I7 | PIKFYVE | S318 | ochoa|psp | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cycle progression (PubMed:23086417). The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Sole enzyme to catalyze the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form (PtdIns(3,5)P2) (PubMed:17556371). Also catalyzes the phosphorylation of phosphatidylinositol on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:22621786). Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate. Autophosphorylation inhibits its own phosphatidylinositol 3-phosphate 5-kinase activity, stimulates FIG4 lipid phosphatase activity and down-regulates lipid product formation (PubMed:33098764). Involved in key endosome operations such as fission and fusion in the course of endosomal cargo transport (PubMed:22621786). Required for the maturation of early into late endosomes, phagosomes and lysosomes (PubMed:30612035). Regulates vacuole maturation and nutrient recovery following engulfment of macromolecules, initiates the redistribution of accumulated lysosomal contents back into the endosome network (PubMed:27623384). Critical regulator of the morphology, degradative activity, and protein turnover of the endolysosomal system in macrophages and platelets (By similarity). In neutrophils, critical to perform chemotaxis, generate ROS, and undertake phagosome fusion with lysosomes (PubMed:28779020). Plays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). Regulates melanosome biogenesis by controlling the delivery of proteins from the endosomal compartment to the melanosome (PubMed:29584722). Essential for systemic glucose homeostasis, mediates insulin-induced signals for endosome/actin remodeling in the course of GLUT4 translocation/glucose uptake activation (By similarity). Supports microtubule-based endosome-to-trans-Golgi network cargo transport, through association with SPAG9 and RABEPK (By similarity). Mediates EGFR trafficking to the nucleus (PubMed:17909029). {ECO:0000250|UniProtKB:Q9Z1T6, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:22621786, ECO:0000269|PubMed:27623384, ECO:0000269|PubMed:28779020, ECO:0000269|PubMed:29584722, ECO:0000269|PubMed:30612035, ECO:0000269|PubMed:33098764, ECO:0000303|PubMed:23086417}.; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC) by endocytosis. {ECO:0000269|PubMed:32221306}. |
| Q9Y2V2 | CARHSP1 | S41 | ochoa|psp | Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) | Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). {ECO:0000269|PubMed:21078874, ECO:0000269|PubMed:21177848}. |
| Q9Y2W1 | THRAP3 | S232 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y314 | NOSIP | S138 | ochoa | Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250|UniProtKB:Q9D6T0, ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
| O60496 | DOK2 | Y271 | iPTMNet|EPSD | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
| H0Y626 | None | S27 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
| O14745 | NHERF1 | S291 | ochoa|psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O60245 | PCDH7 | S989 | ochoa | Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh) | None |
| O60307 | MAST3 | S50 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60641 | SNAP91 | S306 | ochoa | Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20) | Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}. |
| O94885 | SASH1 | S1051 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95049 | TJP3 | S845 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95361 | TRIM16 | S27 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
| P10636 | MAPT | S427 | ochoa | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P26358 | DNMT1 | S143 | ochoa|psp | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18754681, ECO:0000269|PubMed:24623306}. |
| P35713 | SOX18 | S50 | ochoa | Transcription factor SOX-18 | Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. {ECO:0000250|UniProtKB:P43680}. |
| P38159 | RBMX | S208 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P46821 | MAP1B | S1389 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47736 | RAP1GAP | S484 | ochoa|psp | Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15141215}. |
| P49418 | AMPH | S293 | psp | Amphiphysin | May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. |
| P49796 | RGS3 | S728 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| Q08050 | FOXM1 | S693 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q08174 | PCDH1 | S962 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08AD1 | CAMSAP2 | S963 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09472 | EP300 | S2315 | ochoa|psp | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes (PubMed:23415232, PubMed:23934153, PubMed:8945521). Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (PubMed:23415232). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905, PubMed:23911289). Also able to acetylate histone lysine residues that are already monomethylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Catalyzes formation of histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1, SIRT2, STAT3 or GLUL (PubMed:12929931, PubMed:15653507, PubMed:16285960, PubMed:16762839, PubMed:18722353, PubMed:18782771, PubMed:26990986). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement (PubMed:14752053). Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates STAT3 at different sites, promoting both STAT3 dimerization and activation and recruitment to chromatin (PubMed:15653507, PubMed:16285960, PubMed:18782771). Acetylates BCL6 which disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). Acetylates isoform M2 of PKM (PKM2), promoting its homodimerization and conversion into a protein kinase (PubMed:24120661). Acetylates RPTOR in response to leucine, leading to activation of the mTORC1 complex (PubMed:30197302, PubMed:32561715). Acetylates RICTOR, leading to activation of the mTORC2 complex (PubMed:22084251). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREBBP (PubMed:8917528). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:22084251, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:26990986, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37731000, ECO:0000269|PubMed:8917528, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}. |
| Q12906 | ILF3 | S751 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13330 | MTA1 | S449 | ochoa | Metastasis-associated protein MTA1 | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}.; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. {ECO:0000269|PubMed:15077195}. |
| Q13884 | SNTB1 | S225 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q14814 | MEF2D | S201 | ochoa|psp | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15648 | MED1 | S664 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q16204 | CCDC6 | S352 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16204 | CCDC6 | S384 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16625 | OCLN | S358 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
| Q3KQU3 | MAP7D1 | S399 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q5UIP0 | RIF1 | S2161 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT52 | RPRD2 | S965 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUA4 | ZNF318 | S1896 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q6IQ23 | PLEKHA7 | S545 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q76N32 | CEP68 | S238 | ochoa | Centrosomal protein of 68 kDa (Cep68) | Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}. |
| Q7Z2K8 | GPRIN1 | S53 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z2K8 | GPRIN1 | S64 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q7Z3B3 | KANSL1 | S977 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z3K3 | POGZ | S434 | ochoa | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:26721387}. |
| Q8IYB3 | SRRM1 | S420 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S646 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZD0 | SAMD14 | S151 | ochoa | Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14) | None |
| Q8IZW8 | TNS4 | S242 | ochoa | Tensin-4 (C-terminal tensin-like protein) | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}. |
| Q8N3F8 | MICALL1 | T601 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8NDX5 | PHC3 | S304 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8WUF5 | PPP1R13L | S73 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q92610 | ZNF592 | S680 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92793 | CREBBP | S2351 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92835 | INPP5D | S1039 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q96D71 | REPS1 | S392 | ochoa | RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) | May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S208 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96GY3 | LIN37 | T191 | ochoa | Protein lin-37 homolog (Antolefinin) | None |
| Q96L73 | NSD1 | S2369 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96MX3 | ZNF48 | S409 | ochoa | Zinc finger protein 48 (Zinc finger protein 553) | May be involved in transcriptional regulation. |
| Q96PX6 | CCDC85A | S289 | ochoa | Coiled-coil domain-containing protein 85A | May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family. {ECO:0000305|PubMed:25009281}. |
| Q9BTX1 | NDC1 | S406 | ochoa | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873, ECO:0000269|PubMed:16702233}. |
| Q9H3P7 | ACBD3 | S43 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
| Q9H6F5 | CCDC86 | S47 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
| Q9H6K5 | PRR36 | S308 | ochoa | Proline-rich protein 36 | None |
| Q9HA65 | TBC1D17 | S602 | ochoa | TBC1 domain family member 17 | Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Q9HAW0 | BRF2 | S365 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
| Q9HCD6 | TANC2 | S1545 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HCK8 | CHD8 | S2200 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NYB9 | ABI2 | S233 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9P206 | NHSL3 | S562 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UBC2 | EPS15L1 | T366 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBW5 | BIN2 | S425 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UHY1 | NRBP1 | S422 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UKA4 | AKAP11 | S422 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UPN7 | PPP6R1 | S759 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
| Q9UPQ0 | LIMCH1 | S670 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UQ35 | SRRM2 | T1003 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y2H5 | PLEKHA6 | S276 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y4F1 | FARP1 | S503 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y6R9 | CCDC61 | S458 | ochoa | Centrosomal protein CCDC61 (Coiled-coil domain-containing protein 61) (VFL3 homolog) | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.000004 | 5.402 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000107 | 3.972 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.000173 | 3.762 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000183 | 3.738 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.000227 | 3.645 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.000429 | 3.367 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000608 | 3.216 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.000706 | 3.151 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.000706 | 3.151 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.000965 | 3.015 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000982 | 3.008 |
| R-HSA-9707616 | Heme signaling | 0.000968 | 3.014 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.000847 | 3.072 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.001098 | 2.959 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.001891 | 2.723 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.001806 | 2.743 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.002223 | 2.653 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.002223 | 2.653 |
| R-HSA-9843745 | Adipogenesis | 0.002632 | 2.580 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.003657 | 2.437 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.003610 | 2.443 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.004223 | 2.374 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.004223 | 2.374 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.004145 | 2.382 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.005689 | 2.245 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.006089 | 2.215 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.006089 | 2.215 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.005809 | 2.236 |
| R-HSA-2028269 | Signaling by Hippo | 0.005391 | 2.268 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.005689 | 2.245 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.006508 | 2.187 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.007354 | 2.133 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.007665 | 2.116 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.007902 | 2.102 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.008498 | 2.071 |
| R-HSA-9909396 | Circadian clock | 0.009924 | 2.003 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.010372 | 1.984 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.011255 | 1.949 |
| R-HSA-4839726 | Chromatin organization | 0.011459 | 1.941 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.013404 | 1.873 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.013123 | 1.882 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.013478 | 1.870 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.015875 | 1.799 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.015875 | 1.799 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.015101 | 1.821 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.015875 | 1.799 |
| R-HSA-9758941 | Gastrulation | 0.018045 | 1.744 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.020116 | 1.696 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.021614 | 1.665 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.020116 | 1.696 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.024051 | 1.619 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.024051 | 1.619 |
| R-HSA-157118 | Signaling by NOTCH | 0.024017 | 1.619 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.024051 | 1.619 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.023776 | 1.624 |
| R-HSA-186712 | Regulation of beta-cell development | 0.022679 | 1.644 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.027085 | 1.567 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.024904 | 1.604 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.026065 | 1.584 |
| R-HSA-9842663 | Signaling by LTK | 0.027085 | 1.567 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.026400 | 1.578 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.028776 | 1.541 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.033533 | 1.475 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.033584 | 1.474 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.031027 | 1.508 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.030265 | 1.519 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.033584 | 1.474 |
| R-HSA-8853659 | RET signaling | 0.031656 | 1.500 |
| R-HSA-1483255 | PI Metabolism | 0.035092 | 1.455 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.031656 | 1.500 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.037039 | 1.431 |
| R-HSA-3371568 | Attenuation phase | 0.039506 | 1.403 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.037962 | 1.421 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.039506 | 1.403 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.039506 | 1.403 |
| R-HSA-202433 | Generation of second messenger molecules | 0.039506 | 1.403 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.037039 | 1.431 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.037373 | 1.427 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.039506 | 1.403 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.045714 | 1.340 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.044333 | 1.353 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.044333 | 1.353 |
| R-HSA-74160 | Gene expression (Transcription) | 0.047415 | 1.324 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.047961 | 1.319 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.048163 | 1.317 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.042515 | 1.371 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.076136 | 1.118 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.076136 | 1.118 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.090655 | 1.043 |
| R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling | 0.090655 | 1.043 |
| R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer | 0.090655 | 1.043 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.104948 | 0.979 |
| R-HSA-203754 | NOSIP mediated eNOS trafficking | 0.104948 | 0.979 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.119016 | 0.924 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 0.119016 | 0.924 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.132864 | 0.877 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.146496 | 0.834 |
| R-HSA-112412 | SOS-mediated signalling | 0.146496 | 0.834 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.056165 | 1.251 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.064593 | 1.190 |
| R-HSA-68952 | DNA replication initiation | 0.186122 | 0.730 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.073414 | 1.134 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 0.223916 | 0.650 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 0.223916 | 0.650 |
| R-HSA-69091 | Polymerase switching | 0.223916 | 0.650 |
| R-HSA-69109 | Leading Strand Synthesis | 0.223916 | 0.650 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.223916 | 0.650 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.223916 | 0.650 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.223916 | 0.650 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.096973 | 1.013 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.111995 | 0.951 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.248136 | 0.605 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.117130 | 0.931 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.117130 | 0.931 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.127571 | 0.894 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.127571 | 0.894 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.068286 | 1.166 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.132871 | 0.877 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.271602 | 0.566 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.143617 | 0.843 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.283060 | 0.548 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.283060 | 0.548 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.094573 | 1.024 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.094573 | 1.024 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.094573 | 1.024 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.094573 | 1.024 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.094573 | 1.024 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.165610 | 0.781 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.171198 | 0.767 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.327126 | 0.485 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.138504 | 0.859 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.172230 | 0.764 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.251700 | 0.599 |
| R-HSA-72649 | Translation initiation complex formation | 0.257534 | 0.589 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.292533 | 0.534 |
| R-HSA-1989781 | PPARA activates gene expression | 0.141998 | 0.848 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.344540 | 0.463 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.138221 | 0.859 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 0.337714 | 0.471 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.146834 | 0.833 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.191883 | 0.717 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.092104 | 1.036 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.253643 | 0.596 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.348136 | 0.458 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.259962 | 0.585 |
| R-HSA-3371556 | Cellular response to heat stress | 0.065136 | 1.186 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.337183 | 0.472 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.073491 | 1.134 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.073491 | 1.134 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.223916 | 0.650 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.236122 | 0.627 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.259962 | 0.585 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.068286 | 1.166 |
| R-HSA-69190 | DNA strand elongation | 0.122323 | 0.912 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.073491 | 1.134 |
| R-HSA-4641265 | Repression of WNT target genes | 0.223916 | 0.650 |
| R-HSA-9710421 | Defective pyroptosis | 0.193837 | 0.713 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.296250 | 0.528 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.334948 | 0.475 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.114020 | 0.943 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.114020 | 0.943 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.167859 | 0.775 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.198920 | 0.701 |
| R-HSA-8851805 | MET activates RAS signaling | 0.223916 | 0.650 |
| R-HSA-74749 | Signal attenuation | 0.186122 | 0.730 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.132871 | 0.877 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.348136 | 0.458 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.266347 | 0.575 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.339249 | 0.469 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.248136 | 0.605 |
| R-HSA-69239 | Synthesis of DNA | 0.291961 | 0.535 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.339249 | 0.469 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.076136 | 1.118 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.076136 | 1.118 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.198920 | 0.701 |
| R-HSA-428540 | Activation of RAC1 | 0.211517 | 0.675 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.211517 | 0.675 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.259962 | 0.585 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.271602 | 0.566 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.271602 | 0.566 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.271602 | 0.566 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.283060 | 0.548 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.154537 | 0.811 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.305441 | 0.515 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.305441 | 0.515 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.171198 | 0.767 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.337714 | 0.471 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.205297 | 0.688 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.348136 | 0.458 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.348136 | 0.458 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.241030 | 0.618 |
| R-HSA-9646399 | Aggrephagy | 0.171198 | 0.767 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.280291 | 0.552 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.111995 | 0.951 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.159914 | 0.796 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.138221 | 0.859 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.294339 | 0.531 |
| R-HSA-9824272 | Somitogenesis | 0.205297 | 0.688 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.156955 | 0.804 |
| R-HSA-167172 | Transcription of the HIV genome | 0.338812 | 0.470 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.146496 | 0.834 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.186122 | 0.730 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.223916 | 0.650 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.132871 | 0.877 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.263371 | 0.579 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.117130 | 0.931 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.127571 | 0.894 |
| R-HSA-69275 | G2/M Transition | 0.109435 | 0.961 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.113159 | 0.946 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.186122 | 0.730 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 0.198920 | 0.701 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.077961 | 1.108 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.211517 | 0.675 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.305441 | 0.515 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.327126 | 0.485 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.280878 | 0.551 |
| R-HSA-191859 | snRNP Assembly | 0.286708 | 0.543 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.286708 | 0.543 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.298352 | 0.525 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.094072 | 1.027 |
| R-HSA-69242 | S Phase | 0.125644 | 0.901 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.111995 | 0.951 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.154537 | 0.811 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.304164 | 0.517 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.211517 | 0.675 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.132871 | 0.877 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 0.173122 | 0.762 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.186122 | 0.730 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.223916 | 0.650 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 0.223916 | 0.650 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.248136 | 0.605 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.259962 | 0.585 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.259962 | 0.585 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.138221 | 0.859 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.100905 | 0.996 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.149056 | 0.827 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.182465 | 0.739 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.249145 | 0.604 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.305441 | 0.515 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.225482 | 0.647 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.123382 | 0.909 |
| R-HSA-425986 | Sodium/Proton exchangers | 0.159914 | 0.796 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.173122 | 0.762 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.068957 | 1.161 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.223916 | 0.650 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.236122 | 0.627 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.259962 | 0.585 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.165610 | 0.781 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.171198 | 0.767 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.171198 | 0.767 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.176817 | 0.752 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.316369 | 0.500 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.096973 | 1.013 |
| R-HSA-177929 | Signaling by EGFR | 0.082430 | 1.084 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.149056 | 0.827 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.142742 | 0.845 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.139795 | 0.855 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.149056 | 0.827 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 0.198920 | 0.701 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.294339 | 0.531 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.294339 | 0.531 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.316369 | 0.500 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.348136 | 0.458 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.173986 | 0.759 |
| R-HSA-6806834 | Signaling by MET | 0.164539 | 0.784 |
| R-HSA-210993 | Tie2 Signaling | 0.052108 | 1.283 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.262901 | 0.580 |
| R-HSA-1640170 | Cell Cycle | 0.183616 | 0.736 |
| R-HSA-212436 | Generic Transcription Pathway | 0.165750 | 0.781 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.119016 | 0.924 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.119016 | 0.924 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.127571 | 0.894 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.160056 | 0.796 |
| R-HSA-167044 | Signalling to RAS | 0.337714 | 0.471 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.211054 | 0.676 |
| R-HSA-3214847 | HATs acetylate histones | 0.253643 | 0.596 |
| R-HSA-202403 | TCR signaling | 0.130099 | 0.886 |
| R-HSA-162587 | HIV Life Cycle | 0.146834 | 0.833 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.082594 | 1.083 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.283060 | 0.548 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.106922 | 0.971 |
| R-HSA-180786 | Extension of Telomeres | 0.286708 | 0.543 |
| R-HSA-199991 | Membrane Trafficking | 0.068298 | 1.166 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.337714 | 0.471 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.337714 | 0.471 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.117130 | 0.931 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.283060 | 0.548 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.165610 | 0.781 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.188139 | 0.726 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.273832 | 0.563 |
| R-HSA-69206 | G1/S Transition | 0.183317 | 0.737 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.176817 | 0.752 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.168151 | 0.774 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.222616 | 0.652 |
| R-HSA-9663891 | Selective autophagy | 0.199898 | 0.699 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.111995 | 0.951 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.135659 | 0.868 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.275044 | 0.561 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.127571 | 0.894 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.236122 | 0.627 |
| R-HSA-9833110 | RSV-host interactions | 0.114020 | 0.943 |
| R-HSA-210990 | PECAM1 interactions | 0.198920 | 0.701 |
| R-HSA-525793 | Myogenesis | 0.092104 | 1.036 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.259962 | 0.585 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.082430 | 1.084 |
| R-HSA-392517 | Rap1 signalling | 0.316369 | 0.500 |
| R-HSA-8854214 | TBC/RABGAPs | 0.193837 | 0.713 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.218265 | 0.661 |
| R-HSA-1266738 | Developmental Biology | 0.114684 | 0.940 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.248136 | 0.605 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.146496 | 0.834 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.248136 | 0.605 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.271602 | 0.566 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.154537 | 0.811 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.154218 | 0.812 |
| R-HSA-9675108 | Nervous system development | 0.058447 | 1.233 |
| R-HSA-162582 | Signal Transduction | 0.072686 | 1.139 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.294339 | 0.531 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.304164 | 0.517 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.198920 | 0.701 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.348136 | 0.458 |
| R-HSA-422475 | Axon guidance | 0.117628 | 0.929 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.159914 | 0.796 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.173122 | 0.762 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.186122 | 0.730 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.068957 | 1.161 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.259962 | 0.585 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.294339 | 0.531 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.127571 | 0.894 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.271602 | 0.566 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.079507 | 1.100 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.199898 | 0.699 |
| R-HSA-201556 | Signaling by ALK | 0.165610 | 0.781 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.290812 | 0.536 |
| R-HSA-9607240 | FLT3 Signaling | 0.176817 | 0.752 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.156955 | 0.804 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.054284 | 1.265 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.223916 | 0.650 |
| R-HSA-5358508 | Mismatch Repair | 0.305441 | 0.515 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.138504 | 0.859 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.269208 | 0.570 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.138221 | 0.859 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.155847 | 0.807 |
| R-HSA-6807070 | PTEN Regulation | 0.235553 | 0.628 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.167075 | 0.777 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.122323 | 0.912 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.188139 | 0.726 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.075963 | 1.119 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.236122 | 0.627 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.269208 | 0.570 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.294339 | 0.531 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.228827 | 0.640 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.248136 | 0.605 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.316369 | 0.500 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.276798 | 0.558 |
| R-HSA-109581 | Apoptosis | 0.319104 | 0.496 |
| R-HSA-75153 | Apoptotic execution phase | 0.211054 | 0.676 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.337714 | 0.471 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.199557 | 0.700 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.253643 | 0.596 |
| R-HSA-73887 | Death Receptor Signaling | 0.290812 | 0.536 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.350251 | 0.456 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.350251 | 0.456 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.350251 | 0.456 |
| R-HSA-162906 | HIV Infection | 0.353718 | 0.451 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.354739 | 0.450 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.355946 | 0.449 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.355946 | 0.449 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.358308 | 0.446 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.358394 | 0.446 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.358394 | 0.446 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.358394 | 0.446 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.358394 | 0.446 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.358394 | 0.446 |
| R-HSA-73886 | Chromosome Maintenance | 0.360720 | 0.443 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.361623 | 0.442 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.361623 | 0.442 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.361623 | 0.442 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.364450 | 0.438 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.368492 | 0.434 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.368492 | 0.434 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.372921 | 0.428 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.372921 | 0.428 |
| R-HSA-429947 | Deadenylation of mRNA | 0.378432 | 0.422 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.378432 | 0.422 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.378432 | 0.422 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.378432 | 0.422 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.378432 | 0.422 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.378432 | 0.422 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.378432 | 0.422 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.378432 | 0.422 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.378539 | 0.422 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.378539 | 0.422 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.378539 | 0.422 |
| R-HSA-2262752 | Cellular responses to stress | 0.381674 | 0.418 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.384137 | 0.416 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.388216 | 0.411 |
| R-HSA-2160916 | Hyaluronan degradation | 0.388216 | 0.411 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.388216 | 0.411 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.388216 | 0.411 |
| R-HSA-9839394 | TGFBR3 expression | 0.388216 | 0.411 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.394835 | 0.404 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.395267 | 0.403 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.395267 | 0.403 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.395267 | 0.403 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.397846 | 0.400 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.397846 | 0.400 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.397846 | 0.400 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.397846 | 0.400 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.397846 | 0.400 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.397846 | 0.400 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.397846 | 0.400 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.397846 | 0.400 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.406304 | 0.391 |
| R-HSA-9833482 | PKR-mediated signaling | 0.406304 | 0.391 |
| R-HSA-201451 | Signaling by BMP | 0.407325 | 0.390 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.407325 | 0.390 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.407325 | 0.390 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.407325 | 0.390 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.407325 | 0.390 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.407325 | 0.390 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.407325 | 0.390 |
| R-HSA-1474165 | Reproduction | 0.407514 | 0.390 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.416656 | 0.380 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.416656 | 0.380 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.416656 | 0.380 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.416656 | 0.380 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.416656 | 0.380 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.422017 | 0.375 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.422676 | 0.374 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.425840 | 0.371 |
| R-HSA-5334118 | DNA methylation | 0.425840 | 0.371 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.425840 | 0.371 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.425840 | 0.371 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.425840 | 0.371 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.425840 | 0.371 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.428082 | 0.368 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.428082 | 0.368 |
| R-HSA-2424491 | DAP12 signaling | 0.434881 | 0.362 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.434881 | 0.362 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.434881 | 0.362 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.434881 | 0.362 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.436269 | 0.360 |
| R-HSA-182971 | EGFR downregulation | 0.443779 | 0.353 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.443779 | 0.353 |
| R-HSA-186763 | Downstream signal transduction | 0.443779 | 0.353 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.451823 | 0.345 |
| R-HSA-1538133 | G0 and Early G1 | 0.452538 | 0.344 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.457138 | 0.340 |
| R-HSA-1632852 | Macroautophagy | 0.457339 | 0.340 |
| R-HSA-9930044 | Nuclear RNA decay | 0.461160 | 0.336 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.461160 | 0.336 |
| R-HSA-9733709 | Cardiogenesis | 0.461160 | 0.336 |
| R-HSA-354192 | Integrin signaling | 0.461160 | 0.336 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.465151 | 0.332 |
| R-HSA-73884 | Base Excision Repair | 0.465151 | 0.332 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.465478 | 0.332 |
| R-HSA-390522 | Striated Muscle Contraction | 0.469646 | 0.328 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.469646 | 0.328 |
| R-HSA-72172 | mRNA Splicing | 0.474330 | 0.324 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.475482 | 0.323 |
| R-HSA-5357801 | Programmed Cell Death | 0.477745 | 0.321 |
| R-HSA-2142845 | Hyaluronan metabolism | 0.477999 | 0.321 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.477999 | 0.321 |
| R-HSA-5205647 | Mitophagy | 0.477999 | 0.321 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.477999 | 0.321 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.480319 | 0.318 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.482734 | 0.316 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.486221 | 0.313 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.486221 | 0.313 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.486221 | 0.313 |
| R-HSA-187687 | Signalling to ERKs | 0.486221 | 0.313 |
| R-HSA-166520 | Signaling by NTRKs | 0.489564 | 0.310 |
| R-HSA-3371511 | HSF1 activation | 0.494314 | 0.306 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.494314 | 0.306 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.494314 | 0.306 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.494314 | 0.306 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.495776 | 0.305 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.497476 | 0.303 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.500772 | 0.300 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.502280 | 0.299 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.505735 | 0.296 |
| R-HSA-69306 | DNA Replication | 0.509228 | 0.293 |
| R-HSA-8875878 | MET promotes cell motility | 0.510121 | 0.292 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.510121 | 0.292 |
| R-HSA-157579 | Telomere Maintenance | 0.510667 | 0.292 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.510667 | 0.292 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.516982 | 0.287 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.517839 | 0.286 |
| R-HSA-9612973 | Autophagy | 0.520835 | 0.283 |
| R-HSA-70171 | Glycolysis | 0.525268 | 0.280 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.525436 | 0.279 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.525436 | 0.279 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.525436 | 0.279 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.525436 | 0.279 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.528491 | 0.277 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.532914 | 0.273 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.532914 | 0.273 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.534838 | 0.272 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.534838 | 0.272 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.536078 | 0.271 |
| R-HSA-167161 | HIV Transcription Initiation | 0.540274 | 0.267 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.540274 | 0.267 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.540274 | 0.267 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.540274 | 0.267 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.540274 | 0.267 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.547519 | 0.262 |
| R-HSA-73928 | Depyrimidination | 0.547519 | 0.262 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.554650 | 0.256 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.554650 | 0.256 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.554650 | 0.256 |
| R-HSA-1483257 | Phospholipid metabolism | 0.559152 | 0.252 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.559152 | 0.252 |
| R-HSA-2172127 | DAP12 interactions | 0.561669 | 0.251 |
| R-HSA-211000 | Gene Silencing by RNA | 0.562749 | 0.250 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.567284 | 0.246 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.567284 | 0.246 |
| R-HSA-195721 | Signaling by WNT | 0.567551 | 0.246 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.568578 | 0.245 |
| R-HSA-774815 | Nucleosome assembly | 0.568578 | 0.245 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.568578 | 0.245 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.568578 | 0.245 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.568578 | 0.245 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.568578 | 0.245 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.571784 | 0.243 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.575379 | 0.240 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.575379 | 0.240 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.575379 | 0.240 |
| R-HSA-72306 | tRNA processing | 0.576539 | 0.239 |
| R-HSA-8939211 | ESR-mediated signaling | 0.581687 | 0.235 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.585081 | 0.233 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.585081 | 0.233 |
| R-HSA-5620924 | Intraflagellar transport | 0.588661 | 0.230 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.588661 | 0.230 |
| R-HSA-425410 | Metal ion SLC transporters | 0.588661 | 0.230 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.594188 | 0.226 |
| R-HSA-73893 | DNA Damage Bypass | 0.595146 | 0.225 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.601529 | 0.221 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.606562 | 0.217 |
| R-HSA-168255 | Influenza Infection | 0.607962 | 0.216 |
| R-HSA-373760 | L1CAM interactions | 0.610756 | 0.214 |
| R-HSA-72187 | mRNA 3'-end processing | 0.613996 | 0.212 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.613996 | 0.212 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.613996 | 0.212 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.613996 | 0.212 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.613996 | 0.212 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.614916 | 0.211 |
| R-HSA-70326 | Glucose metabolism | 0.614916 | 0.211 |
| R-HSA-1500931 | Cell-Cell communication | 0.616154 | 0.210 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.620083 | 0.208 |
| R-HSA-1221632 | Meiotic synapsis | 0.620083 | 0.208 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.620083 | 0.208 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.623134 | 0.205 |
| R-HSA-1280218 | Adaptive Immune System | 0.625121 | 0.204 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.626075 | 0.203 |
| R-HSA-68875 | Mitotic Prophase | 0.627193 | 0.203 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.631972 | 0.199 |
| R-HSA-6798695 | Neutrophil degranulation | 0.634461 | 0.198 |
| R-HSA-5688426 | Deubiquitination | 0.634677 | 0.197 |
| R-HSA-8957322 | Metabolism of steroids | 0.636705 | 0.196 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.637492 | 0.196 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.637777 | 0.195 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.637777 | 0.195 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.637777 | 0.195 |
| R-HSA-75893 | TNF signaling | 0.637777 | 0.195 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.643087 | 0.192 |
| R-HSA-112399 | IRS-mediated signalling | 0.643490 | 0.191 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.643490 | 0.191 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.649114 | 0.188 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.649114 | 0.188 |
| R-HSA-194138 | Signaling by VEGF | 0.650832 | 0.187 |
| R-HSA-9033241 | Peroxisomal protein import | 0.654650 | 0.184 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.654650 | 0.184 |
| R-HSA-983189 | Kinesins | 0.660098 | 0.180 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.660098 | 0.180 |
| R-HSA-9609690 | HCMV Early Events | 0.662973 | 0.179 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.665461 | 0.177 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.665461 | 0.177 |
| R-HSA-186797 | Signaling by PDGF | 0.670739 | 0.173 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.675935 | 0.170 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.675935 | 0.170 |
| R-HSA-373755 | Semaphorin interactions | 0.675935 | 0.170 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.680413 | 0.167 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.680485 | 0.167 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.681049 | 0.167 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.681049 | 0.167 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.683941 | 0.165 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.686082 | 0.164 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.691037 | 0.160 |
| R-HSA-9679506 | SARS-CoV Infections | 0.694523 | 0.158 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.695913 | 0.157 |
| R-HSA-9830369 | Kidney development | 0.695913 | 0.157 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.700713 | 0.154 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.700713 | 0.154 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.704799 | 0.152 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.710087 | 0.149 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.710087 | 0.149 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.710087 | 0.149 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.711361 | 0.148 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.711361 | 0.148 |
| R-HSA-9664407 | Parasite infection | 0.711361 | 0.148 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.714633 | 0.146 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.714664 | 0.146 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.719169 | 0.143 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.719169 | 0.143 |
| R-HSA-73894 | DNA Repair | 0.720486 | 0.142 |
| R-HSA-68882 | Mitotic Anaphase | 0.722939 | 0.141 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.723603 | 0.140 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.723603 | 0.140 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.725576 | 0.139 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.727967 | 0.138 |
| R-HSA-380287 | Centrosome maturation | 0.732263 | 0.135 |
| R-HSA-8852135 | Protein ubiquitination | 0.732263 | 0.135 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.732263 | 0.135 |
| R-HSA-5689603 | UCH proteinases | 0.736491 | 0.133 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.740653 | 0.130 |
| R-HSA-9659379 | Sensory processing of sound | 0.748781 | 0.126 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.751528 | 0.124 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.751528 | 0.124 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.752749 | 0.123 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.752749 | 0.123 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.753307 | 0.123 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.754410 | 0.122 |
| R-HSA-9610379 | HCMV Late Events | 0.765653 | 0.116 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.768007 | 0.115 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.771673 | 0.113 |
| R-HSA-1500620 | Meiosis | 0.771673 | 0.113 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.774290 | 0.111 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.775281 | 0.111 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.775281 | 0.111 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.775281 | 0.111 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.778832 | 0.109 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.782327 | 0.107 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.785768 | 0.105 |
| R-HSA-156902 | Peptide chain elongation | 0.785768 | 0.105 |
| R-HSA-5619102 | SLC transporter disorders | 0.791825 | 0.101 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.792487 | 0.101 |
| R-HSA-202424 | Downstream TCR signaling | 0.792487 | 0.101 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.795767 | 0.099 |
| R-HSA-9609646 | HCMV Infection | 0.802004 | 0.096 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.802173 | 0.096 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.802173 | 0.096 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.805301 | 0.094 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.805301 | 0.094 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.808584 | 0.092 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.810878 | 0.091 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.811410 | 0.091 |
| R-HSA-9824446 | Viral Infection Pathways | 0.813111 | 0.090 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.813148 | 0.090 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.814392 | 0.089 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.814392 | 0.089 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.817327 | 0.088 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.817327 | 0.088 |
| R-HSA-1296071 | Potassium Channels | 0.817327 | 0.088 |
| R-HSA-190236 | Signaling by FGFR | 0.823060 | 0.085 |
| R-HSA-2559583 | Cellular Senescence | 0.824135 | 0.084 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.826819 | 0.083 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.828613 | 0.082 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.831325 | 0.080 |
| R-HSA-3781865 | Diseases of glycosylation | 0.832505 | 0.080 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.833993 | 0.079 |
| R-HSA-192823 | Viral mRNA Translation | 0.836620 | 0.077 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.837423 | 0.077 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.839205 | 0.076 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.839205 | 0.076 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.844253 | 0.074 |
| R-HSA-5617833 | Cilium Assembly | 0.844389 | 0.073 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.846718 | 0.072 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.848178 | 0.072 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.849144 | 0.071 |
| R-HSA-446728 | Cell junction organization | 0.852111 | 0.070 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.853882 | 0.069 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.855505 | 0.068 |
| R-HSA-9658195 | Leishmania infection | 0.856766 | 0.067 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.856766 | 0.067 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.857675 | 0.067 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.860712 | 0.065 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.862510 | 0.064 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.865087 | 0.063 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.865087 | 0.063 |
| R-HSA-8953854 | Metabolism of RNA | 0.874617 | 0.058 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.877410 | 0.057 |
| R-HSA-5693538 | Homology Directed Repair | 0.877410 | 0.057 |
| R-HSA-68886 | M Phase | 0.882869 | 0.054 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.883144 | 0.054 |
| R-HSA-913531 | Interferon Signaling | 0.884020 | 0.054 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.886817 | 0.052 |
| R-HSA-418990 | Adherens junctions interactions | 0.891727 | 0.050 |
| R-HSA-114608 | Platelet degranulation | 0.895506 | 0.048 |
| R-HSA-8951664 | Neddylation | 0.895778 | 0.048 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.903529 | 0.044 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.906564 | 0.043 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.915110 | 0.039 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.925425 | 0.034 |
| R-HSA-421270 | Cell-cell junction organization | 0.929213 | 0.032 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.931048 | 0.031 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.931278 | 0.031 |
| R-HSA-597592 | Post-translational protein modification | 0.932065 | 0.031 |
| R-HSA-9609507 | Protein localization | 0.934281 | 0.030 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.938357 | 0.028 |
| R-HSA-9711097 | Cellular response to starvation | 0.939336 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 0.940310 | 0.027 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.944893 | 0.025 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.944893 | 0.025 |
| R-HSA-168249 | Innate Immune System | 0.946152 | 0.024 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.947704 | 0.023 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.950739 | 0.022 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.952984 | 0.021 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.953051 | 0.021 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.953051 | 0.021 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.957184 | 0.019 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.961024 | 0.017 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.963088 | 0.016 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.964822 | 0.016 |
| R-HSA-68877 | Mitotic Prometaphase | 0.965933 | 0.015 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.965933 | 0.015 |
| R-HSA-109582 | Hemostasis | 0.972912 | 0.012 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.972971 | 0.012 |
| R-HSA-72766 | Translation | 0.974507 | 0.011 |
| R-HSA-397014 | Muscle contraction | 0.975291 | 0.011 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.975291 | 0.011 |
| R-HSA-1474244 | Extracellular matrix organization | 0.975774 | 0.011 |
| R-HSA-449147 | Signaling by Interleukins | 0.976841 | 0.010 |
| R-HSA-168256 | Immune System | 0.977132 | 0.010 |
| R-HSA-5663205 | Infectious disease | 0.979547 | 0.009 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.981199 | 0.008 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.981315 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.981548 | 0.008 |
| R-HSA-72312 | rRNA processing | 0.982085 | 0.008 |
| R-HSA-1643685 | Disease | 0.984257 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.984332 | 0.007 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.988213 | 0.005 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.988392 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.993774 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.998152 | 0.001 |
| R-HSA-392499 | Metabolism of proteins | 0.998515 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.998777 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998803 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998961 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999600 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999967 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.869 | 0.800 | 1 | 0.887 |
KIS |
0.866 | 0.776 | 1 | 0.838 |
CDK18 |
0.865 | 0.843 | 1 | 0.894 |
DYRK4 |
0.857 | 0.795 | 1 | 0.898 |
CDK17 |
0.857 | 0.839 | 1 | 0.915 |
P38G |
0.857 | 0.851 | 1 | 0.927 |
CDK19 |
0.857 | 0.816 | 1 | 0.890 |
JNK2 |
0.856 | 0.862 | 1 | 0.898 |
CDK1 |
0.855 | 0.800 | 1 | 0.880 |
DYRK2 |
0.853 | 0.780 | 1 | 0.817 |
P38D |
0.852 | 0.840 | 1 | 0.923 |
CDK3 |
0.851 | 0.722 | 1 | 0.912 |
CDK8 |
0.850 | 0.809 | 1 | 0.861 |
CDK16 |
0.849 | 0.802 | 1 | 0.904 |
P38B |
0.849 | 0.836 | 1 | 0.870 |
CLK3 |
0.848 | 0.553 | 1 | 0.583 |
ERK1 |
0.847 | 0.818 | 1 | 0.883 |
CDK7 |
0.846 | 0.797 | 1 | 0.862 |
JNK3 |
0.846 | 0.843 | 1 | 0.875 |
CDK13 |
0.844 | 0.797 | 1 | 0.878 |
HIPK1 |
0.843 | 0.723 | 1 | 0.799 |
CDK12 |
0.843 | 0.798 | 1 | 0.895 |
CDK10 |
0.842 | 0.755 | 1 | 0.874 |
CDK5 |
0.841 | 0.769 | 1 | 0.835 |
CDK14 |
0.840 | 0.798 | 1 | 0.862 |
HIPK4 |
0.838 | 0.563 | 1 | 0.617 |
DYRK1B |
0.837 | 0.735 | 1 | 0.857 |
CLK2 |
0.835 | 0.472 | -3 | 0.785 |
P38A |
0.835 | 0.802 | 1 | 0.811 |
CDK9 |
0.834 | 0.781 | 1 | 0.872 |
JNK1 |
0.832 | 0.763 | 1 | 0.895 |
SRPK1 |
0.830 | 0.384 | -3 | 0.785 |
DYRK1A |
0.827 | 0.636 | 1 | 0.777 |
HIPK3 |
0.826 | 0.694 | 1 | 0.772 |
MAK |
0.826 | 0.578 | -2 | 0.854 |
ERK2 |
0.824 | 0.781 | 1 | 0.839 |
NLK |
0.824 | 0.709 | 1 | 0.625 |
DYRK3 |
0.821 | 0.571 | 1 | 0.766 |
CDK6 |
0.819 | 0.744 | 1 | 0.877 |
CDK4 |
0.818 | 0.766 | 1 | 0.901 |
CLK1 |
0.817 | 0.442 | -3 | 0.779 |
CLK4 |
0.816 | 0.415 | -3 | 0.796 |
ERK5 |
0.814 | 0.418 | 1 | 0.540 |
MTOR |
0.814 | 0.309 | 1 | 0.419 |
SRPK2 |
0.813 | 0.299 | -3 | 0.714 |
ICK |
0.811 | 0.425 | -3 | 0.857 |
CDK2 |
0.810 | 0.576 | 1 | 0.772 |
CDKL5 |
0.805 | 0.228 | -3 | 0.817 |
COT |
0.805 | -0.010 | 2 | 0.807 |
SRPK3 |
0.805 | 0.271 | -3 | 0.751 |
CDKL1 |
0.802 | 0.202 | -3 | 0.822 |
MOK |
0.801 | 0.507 | 1 | 0.692 |
MOS |
0.799 | 0.076 | 1 | 0.304 |
NDR2 |
0.797 | 0.051 | -3 | 0.880 |
PRP4 |
0.796 | 0.460 | -3 | 0.757 |
CDC7 |
0.793 | -0.055 | 1 | 0.261 |
SKMLCK |
0.793 | 0.054 | -2 | 0.880 |
PIM3 |
0.792 | 0.016 | -3 | 0.866 |
PRKD1 |
0.792 | 0.069 | -3 | 0.860 |
GRK1 |
0.790 | 0.044 | -2 | 0.800 |
MST4 |
0.789 | -0.003 | 2 | 0.808 |
RSK2 |
0.789 | 0.048 | -3 | 0.810 |
PRPK |
0.788 | -0.045 | -1 | 0.818 |
ATR |
0.788 | -0.012 | 1 | 0.290 |
ERK7 |
0.788 | 0.297 | 2 | 0.564 |
PRKD2 |
0.787 | 0.062 | -3 | 0.821 |
IKKB |
0.786 | -0.118 | -2 | 0.716 |
TBK1 |
0.785 | -0.128 | 1 | 0.226 |
AURC |
0.785 | 0.058 | -2 | 0.681 |
RAF1 |
0.784 | -0.143 | 1 | 0.253 |
WNK1 |
0.784 | -0.034 | -2 | 0.887 |
CAMK1B |
0.784 | -0.001 | -3 | 0.863 |
NDR1 |
0.783 | -0.013 | -3 | 0.863 |
PIM1 |
0.783 | 0.053 | -3 | 0.824 |
PKN3 |
0.783 | -0.009 | -3 | 0.845 |
GSK3A |
0.783 | 0.253 | 4 | 0.539 |
IKKE |
0.782 | -0.139 | 1 | 0.227 |
P90RSK |
0.782 | 0.038 | -3 | 0.803 |
PKN2 |
0.781 | -0.024 | -3 | 0.857 |
GRK7 |
0.781 | 0.042 | 1 | 0.266 |
CHAK2 |
0.780 | -0.034 | -1 | 0.808 |
PDHK4 |
0.780 | -0.143 | 1 | 0.316 |
NUAK2 |
0.780 | 0.024 | -3 | 0.866 |
RSK3 |
0.779 | 0.015 | -3 | 0.795 |
PKACB |
0.779 | 0.063 | -2 | 0.688 |
CAMLCK |
0.779 | 0.023 | -2 | 0.845 |
MAPKAPK2 |
0.779 | 0.021 | -3 | 0.782 |
NIK |
0.779 | -0.022 | -3 | 0.874 |
PKCD |
0.778 | 0.006 | 2 | 0.713 |
PKACG |
0.778 | 0.003 | -2 | 0.748 |
LATS1 |
0.778 | 0.071 | -3 | 0.883 |
BMPR2 |
0.778 | -0.162 | -2 | 0.844 |
CAMK2G |
0.778 | -0.084 | 2 | 0.754 |
GCN2 |
0.778 | -0.183 | 2 | 0.724 |
DSTYK |
0.777 | -0.142 | 2 | 0.844 |
NEK6 |
0.777 | -0.072 | -2 | 0.819 |
RIPK3 |
0.776 | -0.111 | 3 | 0.699 |
DAPK2 |
0.776 | 0.002 | -3 | 0.868 |
PRKX |
0.776 | 0.072 | -3 | 0.748 |
RSK4 |
0.775 | 0.044 | -3 | 0.795 |
LATS2 |
0.775 | -0.016 | -5 | 0.710 |
IKKA |
0.775 | -0.068 | -2 | 0.713 |
CAMK2D |
0.775 | -0.041 | -3 | 0.849 |
GRK5 |
0.775 | -0.113 | -3 | 0.836 |
MPSK1 |
0.774 | 0.139 | 1 | 0.308 |
CAMK2A |
0.774 | 0.025 | 2 | 0.761 |
BMPR1B |
0.774 | -0.025 | 1 | 0.236 |
MAPKAPK3 |
0.773 | -0.017 | -3 | 0.811 |
PKCB |
0.773 | 0.005 | 2 | 0.675 |
P70S6KB |
0.773 | 0.004 | -3 | 0.818 |
MLK1 |
0.773 | -0.127 | 2 | 0.752 |
PKCA |
0.773 | 0.022 | 2 | 0.667 |
MLK3 |
0.772 | -0.028 | 2 | 0.685 |
AKT2 |
0.771 | 0.062 | -3 | 0.733 |
MNK1 |
0.771 | 0.018 | -2 | 0.799 |
MNK2 |
0.771 | -0.001 | -2 | 0.793 |
PDHK1 |
0.771 | -0.190 | 1 | 0.296 |
PKCG |
0.771 | -0.008 | 2 | 0.676 |
ULK2 |
0.770 | -0.217 | 2 | 0.687 |
DNAPK |
0.770 | -0.015 | 1 | 0.261 |
MLK2 |
0.770 | -0.068 | 2 | 0.742 |
PAK1 |
0.770 | -0.017 | -2 | 0.802 |
TGFBR2 |
0.769 | -0.108 | -2 | 0.747 |
CAMK2B |
0.769 | -0.023 | 2 | 0.745 |
FAM20C |
0.769 | 0.015 | 2 | 0.644 |
NEK7 |
0.769 | -0.190 | -3 | 0.820 |
DLK |
0.768 | -0.156 | 1 | 0.265 |
IRE1 |
0.768 | -0.089 | 1 | 0.241 |
MSK1 |
0.767 | 0.018 | -3 | 0.779 |
MASTL |
0.767 | -0.142 | -2 | 0.789 |
MSK2 |
0.767 | -0.011 | -3 | 0.777 |
AMPKA1 |
0.767 | -0.072 | -3 | 0.876 |
PASK |
0.767 | 0.053 | -3 | 0.886 |
BCKDK |
0.767 | -0.148 | -1 | 0.736 |
MARK4 |
0.767 | -0.082 | 4 | 0.775 |
PKCZ |
0.767 | -0.018 | 2 | 0.708 |
SGK3 |
0.767 | 0.023 | -3 | 0.804 |
PRKD3 |
0.766 | 0.014 | -3 | 0.779 |
GRK6 |
0.766 | -0.127 | 1 | 0.249 |
PKG2 |
0.766 | 0.016 | -2 | 0.691 |
MST3 |
0.765 | 0.009 | 2 | 0.797 |
PAK3 |
0.764 | -0.050 | -2 | 0.788 |
PAK6 |
0.764 | 0.010 | -2 | 0.706 |
PHKG1 |
0.764 | -0.045 | -3 | 0.852 |
AMPKA2 |
0.764 | -0.046 | -3 | 0.855 |
ATM |
0.764 | -0.083 | 1 | 0.249 |
AURB |
0.763 | 0.005 | -2 | 0.671 |
HUNK |
0.763 | -0.182 | 2 | 0.743 |
VRK2 |
0.763 | 0.049 | 1 | 0.353 |
TGFBR1 |
0.763 | -0.057 | -2 | 0.756 |
PKR |
0.763 | -0.075 | 1 | 0.268 |
GSK3B |
0.762 | 0.100 | 4 | 0.535 |
YSK4 |
0.762 | -0.121 | 1 | 0.235 |
RIPK1 |
0.762 | -0.193 | 1 | 0.236 |
WNK3 |
0.762 | -0.227 | 1 | 0.248 |
ALK4 |
0.762 | -0.075 | -2 | 0.784 |
TSSK1 |
0.762 | -0.050 | -3 | 0.893 |
PIM2 |
0.761 | 0.037 | -3 | 0.779 |
NEK9 |
0.761 | -0.188 | 2 | 0.756 |
GRK4 |
0.761 | -0.148 | -2 | 0.810 |
NIM1 |
0.761 | -0.088 | 3 | 0.700 |
ANKRD3 |
0.761 | -0.181 | 1 | 0.268 |
SMG1 |
0.760 | -0.069 | 1 | 0.270 |
PKCH |
0.760 | -0.045 | 2 | 0.649 |
CK1E |
0.760 | 0.012 | -3 | 0.576 |
TSSK2 |
0.760 | -0.090 | -5 | 0.791 |
MYLK4 |
0.759 | -0.017 | -2 | 0.778 |
TAO3 |
0.759 | -0.001 | 1 | 0.278 |
TTBK2 |
0.759 | -0.185 | 2 | 0.621 |
ULK1 |
0.759 | -0.213 | -3 | 0.773 |
AURA |
0.758 | -0.008 | -2 | 0.644 |
PINK1 |
0.758 | 0.120 | 1 | 0.449 |
MLK4 |
0.758 | -0.096 | 2 | 0.660 |
IRE2 |
0.758 | -0.095 | 2 | 0.657 |
CAMK4 |
0.757 | -0.110 | -3 | 0.841 |
AKT1 |
0.757 | 0.033 | -3 | 0.757 |
PKACA |
0.757 | 0.033 | -2 | 0.642 |
DCAMKL1 |
0.756 | -0.021 | -3 | 0.830 |
ACVR2B |
0.756 | -0.092 | -2 | 0.747 |
MEK1 |
0.756 | -0.142 | 2 | 0.768 |
TLK2 |
0.756 | -0.112 | 1 | 0.238 |
QSK |
0.755 | -0.052 | 4 | 0.747 |
PAK2 |
0.755 | -0.065 | -2 | 0.779 |
CK1D |
0.755 | 0.036 | -3 | 0.526 |
NUAK1 |
0.754 | -0.054 | -3 | 0.814 |
DRAK1 |
0.753 | -0.115 | 1 | 0.209 |
MELK |
0.753 | -0.088 | -3 | 0.831 |
NEK2 |
0.753 | -0.134 | 2 | 0.742 |
GRK2 |
0.753 | -0.078 | -2 | 0.707 |
PKCE |
0.752 | 0.020 | 2 | 0.667 |
CHAK1 |
0.752 | -0.154 | 2 | 0.689 |
ALK2 |
0.752 | -0.091 | -2 | 0.764 |
ACVR2A |
0.752 | -0.111 | -2 | 0.731 |
GAK |
0.751 | -0.000 | 1 | 0.302 |
BUB1 |
0.751 | 0.091 | -5 | 0.758 |
SIK |
0.751 | -0.056 | -3 | 0.791 |
GCK |
0.750 | -0.012 | 1 | 0.261 |
QIK |
0.750 | -0.126 | -3 | 0.842 |
AKT3 |
0.750 | 0.051 | -3 | 0.687 |
BMPR1A |
0.750 | -0.070 | 1 | 0.224 |
PLK1 |
0.750 | -0.178 | -2 | 0.743 |
MEK5 |
0.750 | -0.147 | 2 | 0.740 |
PKCT |
0.750 | -0.043 | 2 | 0.650 |
MAPKAPK5 |
0.750 | -0.076 | -3 | 0.739 |
MEKK3 |
0.749 | -0.154 | 1 | 0.257 |
CAMK1G |
0.749 | -0.054 | -3 | 0.784 |
CK1A2 |
0.749 | 0.007 | -3 | 0.529 |
PKCI |
0.748 | -0.020 | 2 | 0.687 |
MEKK2 |
0.748 | -0.118 | 2 | 0.716 |
WNK4 |
0.748 | -0.118 | -2 | 0.876 |
ZAK |
0.748 | -0.153 | 1 | 0.245 |
PLK4 |
0.748 | -0.137 | 2 | 0.527 |
SGK1 |
0.748 | 0.059 | -3 | 0.666 |
MARK3 |
0.747 | -0.072 | 4 | 0.695 |
MEKK1 |
0.747 | -0.152 | 1 | 0.260 |
SMMLCK |
0.747 | -0.024 | -3 | 0.829 |
LKB1 |
0.746 | -0.002 | -3 | 0.821 |
HPK1 |
0.746 | -0.022 | 1 | 0.259 |
NEK5 |
0.746 | -0.129 | 1 | 0.243 |
NEK11 |
0.746 | -0.104 | 1 | 0.268 |
CK1G1 |
0.746 | -0.036 | -3 | 0.551 |
CHK1 |
0.746 | -0.073 | -3 | 0.846 |
PAK5 |
0.746 | -0.022 | -2 | 0.656 |
SBK |
0.745 | 0.137 | -3 | 0.628 |
BRSK1 |
0.745 | -0.086 | -3 | 0.818 |
PDK1 |
0.745 | -0.041 | 1 | 0.278 |
PAK4 |
0.745 | -0.009 | -2 | 0.663 |
TNIK |
0.744 | -0.011 | 3 | 0.819 |
MAP3K15 |
0.744 | -0.047 | 1 | 0.253 |
KHS1 |
0.744 | 0.002 | 1 | 0.253 |
DCAMKL2 |
0.744 | -0.057 | -3 | 0.834 |
KHS2 |
0.743 | 0.015 | 1 | 0.265 |
DAPK3 |
0.743 | -0.010 | -3 | 0.829 |
IRAK4 |
0.743 | -0.140 | 1 | 0.226 |
BRAF |
0.743 | -0.151 | -4 | 0.838 |
P70S6K |
0.743 | -0.030 | -3 | 0.737 |
BRSK2 |
0.743 | -0.117 | -3 | 0.831 |
HASPIN |
0.742 | 0.037 | -1 | 0.680 |
TAO2 |
0.742 | -0.059 | 2 | 0.771 |
PHKG2 |
0.742 | -0.084 | -3 | 0.822 |
PLK3 |
0.742 | -0.158 | 2 | 0.708 |
HGK |
0.741 | -0.050 | 3 | 0.818 |
GRK3 |
0.741 | -0.077 | -2 | 0.670 |
CK2A2 |
0.740 | -0.066 | 1 | 0.207 |
MEKK6 |
0.740 | -0.076 | 1 | 0.262 |
PERK |
0.740 | -0.180 | -2 | 0.784 |
ROCK2 |
0.740 | 0.021 | -3 | 0.823 |
MARK2 |
0.739 | -0.103 | 4 | 0.654 |
TLK1 |
0.739 | -0.171 | -2 | 0.795 |
MINK |
0.739 | -0.091 | 1 | 0.238 |
DAPK1 |
0.739 | -0.014 | -3 | 0.812 |
PKN1 |
0.739 | -0.021 | -3 | 0.757 |
SSTK |
0.738 | -0.076 | 4 | 0.739 |
PBK |
0.738 | -0.013 | 1 | 0.277 |
MRCKB |
0.738 | 0.013 | -3 | 0.771 |
SNRK |
0.738 | -0.189 | 2 | 0.580 |
HRI |
0.737 | -0.216 | -2 | 0.800 |
SLK |
0.737 | -0.043 | -2 | 0.700 |
LOK |
0.736 | -0.054 | -2 | 0.746 |
MST2 |
0.736 | -0.120 | 1 | 0.248 |
NEK8 |
0.735 | -0.169 | 2 | 0.740 |
DMPK1 |
0.735 | 0.049 | -3 | 0.802 |
LRRK2 |
0.735 | -0.027 | 2 | 0.773 |
CAMKK2 |
0.735 | -0.120 | -2 | 0.724 |
CAMK1D |
0.734 | -0.033 | -3 | 0.723 |
CK2A1 |
0.734 | -0.064 | 1 | 0.198 |
CHK2 |
0.734 | -0.004 | -3 | 0.687 |
MARK1 |
0.734 | -0.124 | 4 | 0.716 |
MRCKA |
0.734 | -0.007 | -3 | 0.785 |
NEK4 |
0.733 | -0.149 | 1 | 0.232 |
EEF2K |
0.732 | -0.086 | 3 | 0.757 |
CAMKK1 |
0.732 | -0.199 | -2 | 0.720 |
TAK1 |
0.731 | -0.150 | 1 | 0.239 |
NEK1 |
0.729 | -0.130 | 1 | 0.227 |
YSK1 |
0.728 | -0.092 | 2 | 0.740 |
TTBK1 |
0.728 | -0.193 | 2 | 0.538 |
CRIK |
0.727 | 0.031 | -3 | 0.760 |
MST1 |
0.727 | -0.133 | 1 | 0.237 |
VRK1 |
0.726 | -0.169 | 2 | 0.756 |
CAMK1A |
0.725 | -0.018 | -3 | 0.707 |
PDHK3_TYR |
0.725 | 0.206 | 4 | 0.880 |
STK33 |
0.724 | -0.137 | 2 | 0.536 |
ROCK1 |
0.724 | -0.002 | -3 | 0.786 |
OSR1 |
0.724 | -0.063 | 2 | 0.726 |
PLK2 |
0.723 | -0.094 | -3 | 0.730 |
IRAK1 |
0.720 | -0.274 | -1 | 0.678 |
BIKE |
0.720 | -0.030 | 1 | 0.281 |
PDHK4_TYR |
0.719 | 0.133 | 2 | 0.815 |
CK1A |
0.719 | -0.005 | -3 | 0.438 |
AAK1 |
0.719 | 0.018 | 1 | 0.275 |
PKG1 |
0.718 | -0.030 | -2 | 0.609 |
ASK1 |
0.718 | -0.095 | 1 | 0.251 |
MYO3B |
0.717 | -0.056 | 2 | 0.756 |
YANK3 |
0.717 | -0.051 | 2 | 0.362 |
LIMK2_TYR |
0.716 | 0.155 | -3 | 0.884 |
TESK1_TYR |
0.716 | 0.082 | 3 | 0.817 |
MAP2K4_TYR |
0.715 | 0.087 | -1 | 0.828 |
TAO1 |
0.715 | -0.080 | 1 | 0.243 |
MAP2K6_TYR |
0.715 | 0.081 | -1 | 0.834 |
PKMYT1_TYR |
0.714 | 0.131 | 3 | 0.793 |
BMPR2_TYR |
0.714 | 0.059 | -1 | 0.840 |
MYO3A |
0.713 | -0.088 | 1 | 0.252 |
MEK2 |
0.712 | -0.230 | 2 | 0.718 |
TTK |
0.712 | -0.104 | -2 | 0.774 |
NEK3 |
0.712 | -0.147 | 1 | 0.253 |
ALPHAK3 |
0.711 | -0.080 | -1 | 0.724 |
RIPK2 |
0.711 | -0.252 | 1 | 0.222 |
PDHK1_TYR |
0.711 | 0.016 | -1 | 0.838 |
MAP2K7_TYR |
0.708 | -0.056 | 2 | 0.780 |
PINK1_TYR |
0.704 | -0.118 | 1 | 0.302 |
RET |
0.702 | -0.107 | 1 | 0.272 |
EPHA6 |
0.700 | -0.064 | -1 | 0.801 |
LIMK1_TYR |
0.699 | -0.024 | 2 | 0.763 |
MST1R |
0.699 | -0.081 | 3 | 0.770 |
CSF1R |
0.699 | -0.061 | 3 | 0.752 |
EPHB4 |
0.698 | -0.079 | -1 | 0.759 |
JAK2 |
0.698 | -0.094 | 1 | 0.281 |
ABL2 |
0.697 | -0.058 | -1 | 0.739 |
TXK |
0.695 | -0.055 | 1 | 0.238 |
JAK3 |
0.694 | -0.105 | 1 | 0.263 |
STLK3 |
0.693 | -0.196 | 1 | 0.227 |
ABL1 |
0.693 | -0.072 | -1 | 0.729 |
TYK2 |
0.693 | -0.205 | 1 | 0.259 |
ROS1 |
0.693 | -0.132 | 3 | 0.717 |
TNK2 |
0.692 | -0.074 | 3 | 0.720 |
NEK10_TYR |
0.692 | -0.095 | 1 | 0.240 |
DDR1 |
0.692 | -0.123 | 4 | 0.791 |
FGFR2 |
0.692 | -0.048 | 3 | 0.741 |
LCK |
0.692 | -0.062 | -1 | 0.785 |
FGR |
0.691 | -0.136 | 1 | 0.245 |
KDR |
0.691 | -0.061 | 3 | 0.710 |
JAK1 |
0.691 | -0.067 | 1 | 0.247 |
YES1 |
0.691 | -0.100 | -1 | 0.791 |
TYRO3 |
0.691 | -0.161 | 3 | 0.745 |
KIT |
0.690 | -0.098 | 3 | 0.748 |
EPHA4 |
0.690 | -0.069 | 2 | 0.731 |
TNNI3K_TYR |
0.689 | -0.038 | 1 | 0.293 |
BLK |
0.689 | -0.059 | -1 | 0.786 |
MET |
0.689 | -0.068 | 3 | 0.749 |
TNK1 |
0.688 | -0.059 | 3 | 0.730 |
INSRR |
0.688 | -0.135 | 3 | 0.691 |
CK1G3 |
0.687 | -0.035 | -3 | 0.392 |
ITK |
0.685 | -0.125 | -1 | 0.727 |
HCK |
0.685 | -0.133 | -1 | 0.773 |
DDR2 |
0.685 | -0.015 | 3 | 0.674 |
YANK2 |
0.684 | -0.070 | 2 | 0.377 |
FYN |
0.684 | -0.056 | -1 | 0.779 |
SRMS |
0.684 | -0.152 | 1 | 0.233 |
FGFR1 |
0.684 | -0.074 | 3 | 0.706 |
EPHB1 |
0.683 | -0.160 | 1 | 0.237 |
FGFR3 |
0.683 | -0.058 | 3 | 0.713 |
FLT1 |
0.683 | -0.095 | -1 | 0.769 |
FER |
0.683 | -0.197 | 1 | 0.255 |
BMX |
0.683 | -0.096 | -1 | 0.666 |
TEK |
0.682 | -0.052 | 3 | 0.680 |
FLT3 |
0.682 | -0.182 | 3 | 0.745 |
EPHB2 |
0.681 | -0.137 | -1 | 0.732 |
EPHB3 |
0.681 | -0.147 | -1 | 0.737 |
CK1G2 |
0.680 | -0.025 | -3 | 0.478 |
PDGFRB |
0.680 | -0.210 | 3 | 0.747 |
PTK2 |
0.679 | -0.019 | -1 | 0.767 |
MERTK |
0.679 | -0.145 | 3 | 0.734 |
WEE1_TYR |
0.678 | -0.097 | -1 | 0.684 |
AXL |
0.677 | -0.170 | 3 | 0.733 |
EPHA7 |
0.677 | -0.115 | 2 | 0.714 |
SYK |
0.676 | -0.037 | -1 | 0.742 |
ERBB2 |
0.676 | -0.155 | 1 | 0.241 |
EGFR |
0.676 | -0.098 | 1 | 0.210 |
PDGFRA |
0.674 | -0.216 | 3 | 0.747 |
EPHA3 |
0.674 | -0.130 | 2 | 0.687 |
TEC |
0.673 | -0.161 | -1 | 0.651 |
PTK2B |
0.673 | -0.097 | -1 | 0.694 |
FGFR4 |
0.672 | -0.089 | -1 | 0.696 |
FRK |
0.672 | -0.149 | -1 | 0.767 |
ZAP70 |
0.672 | -0.007 | -1 | 0.683 |
FLT4 |
0.672 | -0.161 | 3 | 0.697 |
ALK |
0.671 | -0.181 | 3 | 0.652 |
EPHA8 |
0.671 | -0.103 | -1 | 0.739 |
MATK |
0.671 | -0.104 | -1 | 0.671 |
SRC |
0.671 | -0.114 | -1 | 0.762 |
EPHA1 |
0.670 | -0.150 | 3 | 0.733 |
INSR |
0.670 | -0.174 | 3 | 0.676 |
NTRK1 |
0.670 | -0.218 | -1 | 0.744 |
NTRK3 |
0.670 | -0.148 | -1 | 0.704 |
LYN |
0.670 | -0.137 | 3 | 0.658 |
ERBB4 |
0.670 | -0.067 | 1 | 0.213 |
LTK |
0.669 | -0.188 | 3 | 0.675 |
BTK |
0.669 | -0.235 | -1 | 0.684 |
EPHA5 |
0.669 | -0.129 | 2 | 0.707 |
CSK |
0.666 | -0.143 | 2 | 0.710 |
NTRK2 |
0.666 | -0.231 | 3 | 0.710 |
PTK6 |
0.664 | -0.234 | -1 | 0.651 |
EPHA2 |
0.663 | -0.105 | -1 | 0.707 |
MUSK |
0.658 | -0.152 | 1 | 0.195 |
IGF1R |
0.656 | -0.158 | 3 | 0.610 |
FES |
0.640 | -0.167 | -1 | 0.637 |