Motif 175 (n=204)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NF01 | POM121B | S281 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
A6NKT7 | RGPD3 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
A7MBM2 | DISP2 | S1270 | ochoa | Protein dispatched homolog 2 | None |
A7MCY6 | TBKBP1 | S365 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
A7MCY6 | TBKBP1 | S372 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
A7MCY6 | TBKBP1 | S393 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
A8CG34 | POM121C | S190 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
A8CG34 | POM121C | S674 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
E9PAV3 | NACA | S1404 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
H0Y626 | None | S31 | ochoa | RING-type E3 ubiquitin transferase (EC 2.3.2.27) | None |
K7ELQ4 | ATF7-NPFF | S304 | ochoa | ATF7-NPFF readthrough | None |
O00330 | PDHX | S162 | ochoa | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
O14686 | KMT2D | S2201 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14715 | RGPD8 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O14994 | SYN3 | S455 | ochoa | Synapsin-3 (Synapsin III) | May be involved in the regulation of neurotransmitter release and synaptogenesis. |
O15034 | RIMBP2 | S651 | ochoa | RIMS-binding protein 2 (RIM-BP2) | Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. {ECO:0000250}. |
O15231 | ZNF185 | S446 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
O15231 | ZNF185 | S512 | ochoa | Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A) | May be involved in the regulation of cellular proliferation and/or differentiation. |
O15534 | PER1 | S27 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
O43281 | EFS | S319 | ochoa | Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3) | Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity). {ECO:0000250}. |
O43426 | SYNJ1 | S1178 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
O43683 | BUB1 | S459 | ochoa|psp | Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}. |
O43896 | KIF1C | S1022 | ochoa | Kinesin-like protein KIF1C | Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}. |
O60336 | MAPKBP1 | S1314 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
O60496 | DOK2 | S282 | ochoa | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}. |
O60885 | BRD4 | S1083 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
O95201 | ZNF205 | S94 | ochoa | Transcriptional repressor RHIT (Repressor of heat-inducible transcription) (RhitH) (Zinc finger protein 205) (Zinc finger protein 210) | Transcriptional repressor involved in regulating MPV17L expression (PubMed:22306510). By regulating MPV17L expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (PubMed:22306510). {ECO:0000269|PubMed:22306510}. |
O95359 | TACC2 | S1267 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
O95361 | TRIM16 | S31 | ochoa | Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein) | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. {ECO:0000269|PubMed:22629402, ECO:0000269|PubMed:27693506, ECO:0000269|PubMed:30143514}. |
O95382 | MAP3K6 | S957 | ochoa | Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) | Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. {ECO:0000269|PubMed:17210579, ECO:0000269|PubMed:9875215}. |
O95503 | CBX6 | S280 | ochoa | Chromobox protein homolog 6 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9DBY5, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. |
P0DJD0 | RGPD1 | S772 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | S780 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P13631 | RARG | S36 | ochoa | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). {ECO:0000250}. |
P17600 | SYN1 | S553 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
P18583 | SON | S966 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
P22532 | SPRR2D | S38 | ochoa | Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II) | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. |
P24278 | ZBTB25 | S220 | ochoa | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | May be involved in transcriptional regulation. |
P25054 | APC | S2323 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
P25054 | APC | S2330 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
P29590 | PML | S38 | ochoa|psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
P46060 | RANGAP1 | S428 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
P46060 | RANGAP1 | S435 | ochoa | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
P46060 | RANGAP1 | S442 | ochoa|psp | Ran GTPase-activating protein 1 (RanGAP1) | GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). {ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050, ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. |
P46087 | NOP2 | S786 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
P47974 | ZFP36L2 | S426 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
P49792 | RANBP2 | S781 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P51610 | HCFC1 | S1507 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
P51825 | AFF1 | S378 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
P52756 | RBM5 | S433 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
P54259 | ATN1 | S168 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
P55201 | BRPF1 | S77 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
P57073 | SOX8 | S344 | ochoa | Transcription factor SOX-8 | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250|UniProtKB:Q04886}. |
P78559 | MAP1A | S2182 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
P78559 | MAP1A | S2366 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
Q00587 | CDC42EP1 | S106 | ochoa | Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55) | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}. |
Q06190 | PPP2R3A | S687 | ochoa | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
Q07889 | SOS1 | S1229 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
Q07890 | SOS2 | S1299 | ochoa | Son of sevenless homolog 2 (SOS-2) | Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250|UniProtKB:Q62245}. |
Q0VF96 | CGNL1 | S112 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
Q0VG06 | FAAP100 | S667 | ochoa | Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa) | Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. {ECO:0000269|PubMed:17396147}. |
Q12815 | TROAP | S334 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
Q12815 | TROAP | S417 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
Q13137 | CALCOCO2 | S390 | ochoa | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}. |
Q13368 | MPP3 | S307 | ochoa | MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) | Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (PubMed:24503895). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity). {ECO:0000250|UniProtKB:O88910, ECO:0000269|PubMed:24503895}. |
Q13425 | SNTB2 | S95 | ochoa | Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
Q13459 | MYO9B | S2035 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
Q13554 | CAMK2B | S522 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
Q13627 | DYRK1A | S555 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
Q14839 | CHD4 | S531 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
Q15139 | PRKD1 | S397 | ochoa | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
Q15459 | SF3A1 | S413 | ochoa | Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006}. |
Q15561 | TEAD4 | S205 | ochoa | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
Q15599 | NHERF2 | S254 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
Q15697 | ZNF174 | S195 | ochoa | Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8) | Transcriptional repressor. {ECO:0000269|PubMed:7673192}. |
Q15772 | SPEG | S313 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q15772 | SPEG | S320 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q15772 | SPEG | S526 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
Q16584 | MAP3K11 | S770 | psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
Q2KJY2 | KIF26B | S1018 | ochoa | Kinesin-like protein KIF26B | Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}. |
Q2TAL8 | QRICH1 | S736 | ochoa | Transcriptional regulator QRICH1 (Glutamine-rich protein 1) | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352}. |
Q3KQU3 | MAP7D1 | S483 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
Q4VCS5 | AMOT | S332 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
Q5JSZ5 | PRRC2B | S1224 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
Q5SW79 | CEP170 | S1515 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5SW79 | CEP170 | S1522 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5T1R4 | HIVEP3 | S2009 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
Q5T5X7 | BEND3 | S710 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
Q5T5Y3 | CAMSAP1 | S862 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
Q5TCZ1 | SH3PXD2A | S406 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
Q5VT52 | RPRD2 | S438 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
Q5VWG9 | TAF3 | S243 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
Q5VWG9 | TAF3 | S667 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
Q63HK3 | ZKSCAN2 | S591 | ochoa | Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) | May be involved in transcriptional regulation. |
Q63HR2 | TNS2 | S972 | ochoa | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
Q684P5 | RAP1GAP2 | S678 | ochoa | Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269|PubMed:15632203}. |
Q68EM7 | ARHGAP17 | S667 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
Q69YQ0 | SPECC1L | S868 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
Q6IPM2 | IQCE | S583 | ochoa | IQ domain-containing protein E | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}. |
Q6P0Q8 | MAST2 | S1351 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
Q6UUV7 | CRTC3 | S443 | ochoa | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. |
Q6ZRV2 | FAM83H | S1061 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
Q6ZS17 | RIPOR1 | S732 | ochoa | Rho family-interacting cell polarization regulator 1 | Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269|PubMed:27807006}. |
Q6ZSS7 | MFSD6 | S766 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
Q6ZTI6 | RFLNA | S37 | ochoa | Refilin-A (Regulator of filamin protein A) (RefilinA) | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. {ECO:0000250|UniProtKB:Q7TS73}. |
Q6ZVM7 | TOM1L2 | S479 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
Q70EL1 | USP54 | S632 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
Q7Z2K8 | GPRIN1 | S53 | ochoa | G protein-regulated inducer of neurite outgrowth 1 (GRIN1) | May be involved in neurite outgrowth. {ECO:0000250}. |
Q7Z3C6 | ATG9A | S656 | ochoa|psp | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
Q7Z3J3 | RGPD4 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q7Z589 | EMSY | S385 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
Q7Z5L9 | IRF2BP2 | S399 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
Q7Z628 | NET1 | S508 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
Q86T24 | ZBTB33 | S237 | ochoa | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). {ECO:0000269|PubMed:11445535, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688, ECO:0000269|PubMed:23251453}. |
Q86UU1 | PHLDB1 | S381 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
Q86UU1 | PHLDB1 | S470 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
Q86XF7 | ZNF575 | S49 | ochoa | Zinc finger protein 575 | May be involved in transcriptional regulation. |
Q86YN6 | PPARGC1B | S256 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
Q8IV63 | VRK3 | S115 | psp | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
Q8IV63 | VRK3 | S122 | ochoa|psp | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
Q8IVF2 | AHNAK2 | S4897 | ochoa | Protein AHNAK2 | None |
Q8IY33 | MICALL2 | S143 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
Q8IY33 | MICALL2 | S249 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
Q8IY33 | MICALL2 | S658 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
Q8IYB3 | SRRM1 | S583 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q8N1I0 | DOCK4 | S1808 | ochoa | Dedicator of cytokinesis protein 4 | Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}. |
Q8N684 | CPSF7 | S60 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
Q8NCN4 | RNF169 | S403 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
Q8NDX1 | PSD4 | S565 | ochoa | PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein) | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}. |
Q8NE35 | CPEB3 | S192 | ochoa | Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3) | Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}. |
Q8NEZ4 | KMT2C | S28 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q8NEZ4 | KMT2C | S3758 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q8TAD8 | SNIP1 | S52 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
Q8TBE0 | BAHD1 | S101 | ochoa | Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) | Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3. {ECO:0000269|PubMed:19666599, ECO:0000269|PubMed:21252314}. |
Q8TCT7 | SPPL2B | S543 | ochoa | Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}. |
Q8TEH3 | DENND1A | S473 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
Q8TEK3 | DOT1L | S902 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190}. |
Q8TER5 | ARHGEF40 | S226 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
Q8TEW8 | PARD3B | S1162 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
Q8WUA7 | TBC1D22A | S132 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
Q8WXE0 | CASKIN2 | S725 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WYQ5 | DGCR8 | S95 | ochoa|psp | Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. |
Q92560 | BAP1 | S485 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922, PubMed:35051358). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:20436459, PubMed:25451922, PubMed:30664650, PubMed:35051358). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459, PubMed:30664650). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:20805357, PubMed:30664650, PubMed:36180891). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (PubMed:30664650). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). Recruited to specific gene-regulatory regions by YY1 (PubMed:20805357). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000269|PubMed:12485996, ECO:0000269|PubMed:18757409, ECO:0000269|PubMed:19117993, ECO:0000269|PubMed:19188440, ECO:0000269|PubMed:19815555, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24703950, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35051358, ECO:0000269|PubMed:36180891}. |
Q92615 | LARP4B | S601 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
Q92738 | USP6NL | S784 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
Q93015 | NAA80 | S217 | ochoa | N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2) | N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992). {ECO:0000269|PubMed:10644992, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29581307, ECO:0000269|PubMed:30028079}. |
Q96B36 | AKT1S1 | S88 | ochoa | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
Q96F44 | TRIM11 | S85 | ochoa | E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11) | E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (By similarity). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (By similarity). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (By similarity). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation (PubMed:16904669). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (PubMed:27498865). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (PubMed:27498865). {ECO:0000250|UniProtKB:Q99PQ2, ECO:0000269|PubMed:16904669, ECO:0000269|PubMed:18248090, ECO:0000269|PubMed:27498865}. |
Q96HA1 | POM121 | S697 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
Q96I24 | FUBP3 | S439 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
Q96IT1 | ZNF496 | S23 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
Q96IT1 | ZNF496 | S30 | ochoa | Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17) | DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}. |
Q96JC9 | EAF1 | S158 | ochoa | ELL-associated factor 1 | Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:16006523}. |
Q96JM3 | CHAMP1 | S253 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96L14 | CEP170P1 | S224 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
Q96L14 | CEP170P1 | S231 | ochoa | Cep170-like protein (CEP170 pseudogene 1) | None |
Q96MM6 | HSPA12B | S46 | ochoa | Heat shock 70 kDa protein 12B (Heat shock protein family A member 12B) | None |
Q96PU8 | QKI | T245 | ochoa | KH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:22398723, PubMed:23630077, PubMed:25768908, PubMed:27029405, PubMed:31331967, PubMed:37379838). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development (PubMed:25768908, PubMed:31829086, PubMed:34428287, PubMed:37379838). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (PubMed:23630077). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons (PubMed:25768908). CircRNAs are produced by back-splicing circularization of pre-mRNAs (PubMed:25768908). Plays a central role in myelinization via 3 distinct mechanisms (PubMed:16641098). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (PubMed:27029405). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (PubMed:31331967). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:23630077, ECO:0000269|PubMed:25768908, ECO:0000269|PubMed:27029405, ECO:0000269|PubMed:31331967, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression (PubMed:31829086). Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 (PubMed:34428287). Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation (PubMed:22398723). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:22398723, ECO:0000269|PubMed:31829086, ECO:0000269|PubMed:34428287}.; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:37379838}.; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (PubMed:37379838). Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation (PubMed:37379838). Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation (PubMed:32732889). Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 (PubMed:31792053). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:31792053, ECO:0000269|PubMed:32732889, ECO:0000269|PubMed:37379838}. |
Q96T58 | SPEN | S3466 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99583 | MNT | S162 | ochoa | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. |
Q99666 | RGPD5 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9BQG0 | MYBBP1A | S1241 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
Q9BVA0 | KATNB1 | S421 | ochoa | Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}. |
Q9BYB0 | SHANK3 | S483 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
Q9BYV9 | BACH2 | S315 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
Q9BZ72 | PITPNM2 | S880 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
Q9C0B0 | UNK | S378 | ochoa|psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9C0C4 | SEMA4C | S772 | ochoa | Semaphorin-4C | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:17498836}. |
Q9C0H5 | ARHGAP39 | S251 | ochoa | Rho GTPase-activating protein 39 | None |
Q9GZY8 | MFF | S202 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
Q9H1K0 | RBSN | S578 | ochoa | Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388). {ECO:0000269|PubMed:11062261, ECO:0000269|PubMed:11788822, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:22308388}. |
Q9H330 | TMEM245 | S332 | ochoa | Transmembrane protein 245 (Protein CG-2) | None |
Q9H3P7 | ACBD3 | S43 | ochoa | Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed] | Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250|UniProtKB:Q8BMP6, ECO:0000269|PubMed:11590181, ECO:0000269|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}. |
Q9H6F5 | CCDC86 | Y164 | ochoa | Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain) | Required for proper chromosome segregation during mitosis and error-free mitotic progression. {ECO:0000269|PubMed:36695333}. |
Q9H6L5 | RETREG1 | S26 | ochoa | Reticulophagy regulator 1 (Reticulophagy receptor 1) | Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q8VE91, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:34338405}.; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:35239449}. |
Q9H792 | PEAK1 | S861 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
Q9H7D0 | DOCK5 | S1756 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
Q9H987 | SYNPO2L | S931 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
Q9HAW0 | BRF2 | S365 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
Q9HCH0 | NCKAP5L | S470 | psp | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}. |
Q9NQT8 | KIF13B | S1481 | ochoa | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269|PubMed:20194617}. |
Q9NVR5 | DNAAF2 | S240 | ochoa | Protein kintoun (Dynein assembly factor 2, axonemal) | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255|HAMAP-Rule:MF_03069}. |
Q9NVR7 | TBCCD1 | S145 | ochoa | TBCC domain-containing protein 1 | Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. {ECO:0000269|PubMed:20168327}. |
Q9NYQ8 | FAT2 | S4258 | ochoa | Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) | Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). {ECO:0000250|UniProtKB:O88277, ECO:0000269|PubMed:18534823}. |
Q9NZ52 | GGA3 | S159 | ochoa|psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
Q9P1Y5 | CAMSAP3 | S547 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9P1Y5 | CAMSAP3 | S756 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
Q9P242 | NYAP2 | S469 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
Q9UBW5 | BIN2 | S349 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
Q9UHB7 | AFF4 | S1055 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
Q9UHI6 | DDX20 | S86 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
Q9UIS9 | MBD1 | S311 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
Q9UK76 | JPT1 | S131 | ochoa | Jupiter microtubule associated homolog 1 (Androgen-regulated protein 2) (Hematological and neurological expressed 1 protein) [Cleaved into: Jupiter microtubule associated homolog 1, N-terminally processed] | Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}. |
Q9UMS6 | SYNPO2 | S604 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UQ35 | SRRM2 | S377 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9Y3A4 | RRP7A | S19 | ochoa | Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14) | Nucleolar protein that is involved in ribosomal RNA (rRNA) processing (PubMed:33199730). Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development (PubMed:33199730). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:33199730, ECO:0000269|PubMed:34516797}. |
Q9Y4B6 | DCAF1 | S895 | ochoa | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (PubMed:23063525). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (By similarity). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:19287380, PubMed:23362280). The EDVP complex also mediates ubiquitination and degradation of CCP110 (PubMed:28242748, PubMed:34259627). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (PubMed:24140421). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). {ECO:0000250|UniProtKB:Q80TR8, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:18606781, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:20644714, ECO:0000269|PubMed:22184063, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:24140421, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.; FUNCTION: (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:17559673, ECO:0000269|PubMed:17609381, ECO:0000269|PubMed:17620334, ECO:0000269|PubMed:17626091, ECO:0000269|PubMed:17630831, ECO:0000269|PubMed:18524771, ECO:0000269|PubMed:24116224}.; FUNCTION: (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. {ECO:0000269|PubMed:17314515, ECO:0000269|PubMed:18464893, ECO:0000269|PubMed:19264781, ECO:0000269|PubMed:19923175, ECO:0000269|PubMed:24336198}. |
Q9Y4C1 | KDM3A | S445 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
Q9Y4U1 | MMACHC | S247 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
Q9Y597 | KCTD3 | S793 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
P35658 | NUP214 | S678 | Sugiyama | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
Q92558 | WASF1 | S397 | iPTMNet | Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:29961568, ECO:0000269|PubMed:9889097}. |
O43734 | TRAF3IP2 | S328 | SIGNOR | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}. |
P00533 | EGFR | S1120 | SIGNOR|iPTMNet | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.000269 | 3.571 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.000328 | 3.485 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.001120 | 2.951 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.001238 | 2.907 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.001238 | 2.907 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.001499 | 2.824 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.001499 | 2.824 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.001643 | 2.784 |
R-HSA-191859 | snRNP Assembly | 0.001582 | 2.801 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.001582 | 2.801 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.001643 | 2.784 |
R-HSA-3371556 | Cellular response to heat stress | 0.001588 | 2.799 |
R-HSA-180746 | Nuclear import of Rev protein | 0.001796 | 2.746 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001959 | 2.708 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.002315 | 2.635 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.002714 | 2.566 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.002929 | 2.533 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.002929 | 2.533 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.002714 | 2.566 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.003156 | 2.501 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.003560 | 2.449 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.004185 | 2.378 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.004379 | 2.359 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.004474 | 2.349 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.004776 | 2.321 |
R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.005720 | 2.243 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.005519 | 2.258 |
R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.005720 | 2.243 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.007601 | 2.119 |
R-HSA-193648 | NRAGE signals death through JNK | 0.008572 | 2.067 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.009034 | 2.044 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.010519 | 1.978 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.011047 | 1.957 |
R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.012282 | 1.911 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.011556 | 1.937 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.011592 | 1.936 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.012925 | 1.889 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.013756 | 1.862 |
R-HSA-428540 | Activation of RAC1 | 0.015140 | 1.820 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.013942 | 1.856 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.015234 | 1.817 |
R-HSA-179812 | GRB2 events in EGFR signaling | 0.017088 | 1.767 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.015717 | 1.804 |
R-HSA-8853659 | RET signaling | 0.016717 | 1.777 |
R-HSA-8983432 | Interleukin-15 signaling | 0.017088 | 1.767 |
R-HSA-211000 | Gene Silencing by RNA | 0.016807 | 1.775 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.018000 | 1.745 |
R-HSA-9796292 | Formation of axial mesoderm | 0.019136 | 1.718 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.019670 | 1.706 |
R-HSA-74160 | Gene expression (Transcription) | 0.019990 | 1.699 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.020277 | 1.693 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.018740 | 1.727 |
R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.021283 | 1.672 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.022243 | 1.653 |
R-HSA-162587 | HIV Life Cycle | 0.022474 | 1.648 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.022724 | 1.644 |
R-HSA-180336 | SHC1 events in EGFR signaling | 0.023524 | 1.628 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.028281 | 1.548 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.028281 | 1.548 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.028281 | 1.548 |
R-HSA-5619102 | SLC transporter disorders | 0.028414 | 1.546 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.030098 | 1.521 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.030098 | 1.521 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.030792 | 1.512 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.030792 | 1.512 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.033388 | 1.476 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.033388 | 1.476 |
R-HSA-210993 | Tie2 Signaling | 0.033388 | 1.476 |
R-HSA-162909 | Host Interactions of HIV factors | 0.029328 | 1.533 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.034575 | 1.461 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.036066 | 1.443 |
R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 0.036398 | 1.439 |
R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.036398 | 1.439 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.036455 | 1.438 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.041659 | 1.380 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.041659 | 1.380 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.044570 | 1.351 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.039700 | 1.401 |
R-HSA-6807070 | PTEN Regulation | 0.045533 | 1.342 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.047554 | 1.323 |
R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 0.048236 | 1.317 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.048645 | 1.313 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.049974 | 1.301 |
R-HSA-70171 | Glycolysis | 0.049974 | 1.301 |
R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.059928 | 1.222 |
R-HSA-8941237 | Invadopodia formation | 0.059928 | 1.222 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.059928 | 1.222 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.059928 | 1.222 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 0.060177 | 1.221 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.053732 | 1.270 |
R-HSA-9609690 | HCMV Early Events | 0.052118 | 1.283 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.060177 | 1.221 |
R-HSA-983189 | Kinesins | 0.053023 | 1.276 |
R-HSA-4839726 | Chromatin organization | 0.051071 | 1.292 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.060177 | 1.221 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.063670 | 1.196 |
R-HSA-73887 | Death Receptor Signaling | 0.063670 | 1.196 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.064346 | 1.191 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.064921 | 1.188 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.071478 | 1.146 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.082887 | 1.082 |
R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.094156 | 1.026 |
R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.094156 | 1.026 |
R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.094156 | 1.026 |
R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.105287 | 0.978 |
R-HSA-112412 | SOS-mediated signalling | 0.116283 | 0.934 |
R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.127143 | 0.896 |
R-HSA-8875656 | MET receptor recycling | 0.127143 | 0.896 |
R-HSA-4839744 | Signaling by APC mutants | 0.158935 | 0.799 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.158935 | 0.799 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.158935 | 0.799 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.158935 | 0.799 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.169274 | 0.771 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.169274 | 0.771 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.179487 | 0.746 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.179487 | 0.746 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.179487 | 0.746 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.179487 | 0.746 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.179487 | 0.746 |
R-HSA-9861559 | PDH complex synthesizes acetyl-CoA from PYR | 0.189575 | 0.722 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.070307 | 1.153 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.199539 | 0.700 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.209381 | 0.679 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.209381 | 0.679 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.228706 | 0.641 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.274987 | 0.561 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.283907 | 0.547 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.283907 | 0.547 |
R-HSA-72187 | mRNA 3'-end processing | 0.170172 | 0.769 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.170172 | 0.769 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.228215 | 0.642 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.125860 | 0.900 |
R-HSA-177929 | Signaling by EGFR | 0.187794 | 0.726 |
R-HSA-180292 | GAB1 signalosome | 0.247561 | 0.606 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.070307 | 1.153 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.250431 | 0.601 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.250431 | 0.601 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.250431 | 0.601 |
R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.179487 | 0.746 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.292716 | 0.534 |
R-HSA-9620244 | Long-term potentiation | 0.318504 | 0.497 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.255493 | 0.593 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.073799 | 1.132 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.228706 | 0.641 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.174551 | 0.758 |
R-HSA-72172 | mRNA Splicing | 0.146071 | 0.835 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.073799 | 1.132 |
R-HSA-8851805 | MET activates RAS signaling | 0.179487 | 0.746 |
R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.228706 | 0.641 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.174156 | 0.759 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.174156 | 0.759 |
R-HSA-74749 | Signal attenuation | 0.148468 | 0.828 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.115428 | 0.938 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.115428 | 0.938 |
R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.335174 | 0.475 |
R-HSA-1227986 | Signaling by ERBB2 | 0.205653 | 0.687 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.082303 | 1.085 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.165314 | 0.782 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.137871 | 0.861 |
R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.158935 | 0.799 |
R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.169274 | 0.771 |
R-HSA-202670 | ERKs are inactivated | 0.169274 | 0.771 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.169274 | 0.771 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.169274 | 0.771 |
R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.219103 | 0.659 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.228706 | 0.641 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.274987 | 0.561 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.283907 | 0.547 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.283907 | 0.547 |
R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.310014 | 0.509 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.335174 | 0.475 |
R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.343357 | 0.464 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.210147 | 0.677 |
R-HSA-5689603 | UCH proteinases | 0.278278 | 0.556 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.238192 | 0.623 |
R-HSA-392517 | Rap1 signalling | 0.256816 | 0.590 |
R-HSA-5362798 | Release of Hh-Np from the secreting cell | 0.094156 | 1.026 |
R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.179487 | 0.746 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.251851 | 0.599 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.241836 | 0.616 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.099051 | 1.004 |
R-HSA-1483226 | Synthesis of PI | 0.158935 | 0.799 |
R-HSA-9609646 | HCMV Infection | 0.119842 | 0.921 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.087689 | 1.057 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.221128 | 0.655 |
R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.310014 | 0.509 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.137871 | 0.861 |
R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.179487 | 0.746 |
R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.209381 | 0.679 |
R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.209381 | 0.679 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.144340 | 0.841 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.144340 | 0.841 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.144340 | 0.841 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.335174 | 0.475 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.109189 | 0.962 |
R-HSA-8948747 | Regulation of PTEN localization | 0.116283 | 0.934 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.179487 | 0.746 |
R-HSA-9027284 | Erythropoietin activates RAS | 0.209381 | 0.679 |
R-HSA-166208 | mTORC1-mediated signalling | 0.292716 | 0.534 |
R-HSA-3371571 | HSF1-dependent transactivation | 0.165812 | 0.780 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.219165 | 0.659 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.260049 | 0.585 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.189537 | 0.722 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.220472 | 0.657 |
R-HSA-68877 | Mitotic Prometaphase | 0.267776 | 0.572 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.148468 | 0.828 |
R-HSA-8953854 | Metabolism of RNA | 0.175567 | 0.756 |
R-HSA-6802949 | Signaling by RAS mutants | 0.144340 | 0.841 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.283907 | 0.547 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.292716 | 0.534 |
R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.318504 | 0.497 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.343357 | 0.464 |
R-HSA-68882 | Mitotic Anaphase | 0.169590 | 0.771 |
R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.318504 | 0.497 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.171614 | 0.765 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.296478 | 0.528 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.084596 | 1.073 |
R-HSA-167044 | Signalling to RAS | 0.274987 | 0.561 |
R-HSA-5362517 | Signaling by Retinoic Acid | 0.205653 | 0.687 |
R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.292716 | 0.534 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.147525 | 0.831 |
R-HSA-9909396 | Circadian clock | 0.112521 | 0.949 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.210147 | 0.677 |
R-HSA-5673000 | RAF activation | 0.092043 | 1.036 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.228706 | 0.641 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.301419 | 0.521 |
R-HSA-6806834 | Signaling by MET | 0.296478 | 0.528 |
R-HSA-68886 | M Phase | 0.233033 | 0.633 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.103552 | 0.985 |
R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.123530 | 0.908 |
R-HSA-198753 | ERK/MAPK targets | 0.274987 | 0.561 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 0.199539 | 0.700 |
R-HSA-2028269 | Signaling by Hippo | 0.238192 | 0.623 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.292716 | 0.534 |
R-HSA-376176 | Signaling by ROBO receptors | 0.142296 | 0.847 |
R-HSA-1433559 | Regulation of KIT signaling | 0.199539 | 0.700 |
R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.318504 | 0.497 |
R-HSA-168255 | Influenza Infection | 0.100592 | 0.997 |
R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.274987 | 0.561 |
R-HSA-3214842 | HDMs demethylate histones | 0.318504 | 0.497 |
R-HSA-162906 | HIV Infection | 0.087721 | 1.057 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.179487 | 0.746 |
R-HSA-5635838 | Activation of SMO | 0.219103 | 0.659 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.326891 | 0.486 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.276935 | 0.558 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.212241 | 0.673 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.190245 | 0.721 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.283907 | 0.547 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.335174 | 0.475 |
R-HSA-9610379 | HCMV Late Events | 0.172460 | 0.763 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.260049 | 0.585 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.127143 | 0.896 |
R-HSA-9762292 | Regulation of CDH11 function | 0.148468 | 0.828 |
R-HSA-9842663 | Signaling by LTK | 0.179487 | 0.746 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.286868 | 0.542 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 0.335174 | 0.475 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.082093 | 1.086 |
R-HSA-162582 | Signal Transduction | 0.300118 | 0.523 |
R-HSA-445144 | Signal transduction by L1 | 0.265958 | 0.575 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.097745 | 1.010 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.077594 | 1.110 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.301419 | 0.521 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.310014 | 0.509 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.286868 | 0.542 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.344027 | 0.463 |
R-HSA-166520 | Signaling by NTRKs | 0.337308 | 0.472 |
R-HSA-9669938 | Signaling by KIT in disease | 0.292716 | 0.534 |
R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.326891 | 0.486 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.260329 | 0.584 |
R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.343357 | 0.464 |
R-HSA-68875 | Mitotic Prophase | 0.085901 | 1.066 |
R-HSA-1236394 | Signaling by ERBB4 | 0.269164 | 0.570 |
R-HSA-212436 | Generic Transcription Pathway | 0.227822 | 0.642 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.301419 | 0.521 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.326891 | 0.486 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.179712 | 0.745 |
R-HSA-70326 | Glucose metabolism | 0.080647 | 1.093 |
R-HSA-913531 | Interferon Signaling | 0.129932 | 0.886 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.194482 | 0.711 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.137884 | 0.860 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.115356 | 0.938 |
R-HSA-451927 | Interleukin-2 family signaling | 0.115428 | 0.938 |
R-HSA-72306 | tRNA processing | 0.207129 | 0.684 |
R-HSA-112310 | Neurotransmitter release cycle | 0.346074 | 0.461 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 0.351439 | 0.454 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.351439 | 0.454 |
R-HSA-9006335 | Signaling by Erythropoietin | 0.351439 | 0.454 |
R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.351439 | 0.454 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.351439 | 0.454 |
R-HSA-2424491 | DAP12 signaling | 0.359422 | 0.444 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.359422 | 0.444 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.359422 | 0.444 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.359422 | 0.444 |
R-HSA-182971 | EGFR downregulation | 0.367307 | 0.435 |
R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.367307 | 0.435 |
R-HSA-399719 | Trafficking of AMPA receptors | 0.367307 | 0.435 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.367307 | 0.435 |
R-HSA-186763 | Downstream signal transduction | 0.367307 | 0.435 |
R-HSA-877300 | Interferon gamma signaling | 0.374170 | 0.427 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.375096 | 0.426 |
R-HSA-1538133 | G0 and Early G1 | 0.375096 | 0.426 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.375096 | 0.426 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.382789 | 0.417 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.382789 | 0.417 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.382789 | 0.417 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.382789 | 0.417 |
R-HSA-354192 | Integrin signaling | 0.382789 | 0.417 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.382789 | 0.417 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.385801 | 0.414 |
R-HSA-3214847 | HATs acetylate histones | 0.394492 | 0.404 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.397894 | 0.400 |
R-HSA-5205647 | Mitophagy | 0.397894 | 0.400 |
R-HSA-422475 | Axon guidance | 0.400451 | 0.397 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.405308 | 0.392 |
R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.405308 | 0.392 |
R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.405308 | 0.392 |
R-HSA-187687 | Signalling to ERKs | 0.405308 | 0.392 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.407422 | 0.390 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.412631 | 0.384 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.412631 | 0.384 |
R-HSA-111933 | Calmodulin induced events | 0.412631 | 0.384 |
R-HSA-111997 | CaM pathway | 0.412631 | 0.384 |
R-HSA-9682385 | FLT3 signaling in disease | 0.412631 | 0.384 |
R-HSA-9679506 | SARS-CoV Infections | 0.419196 | 0.378 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.419865 | 0.377 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.434067 | 0.362 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.434067 | 0.362 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.437061 | 0.359 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.439783 | 0.357 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.441037 | 0.356 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.441037 | 0.356 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.444775 | 0.352 |
R-HSA-199991 | Membrane Trafficking | 0.445509 | 0.351 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.447923 | 0.349 |
R-HSA-9607240 | FLT3 Signaling | 0.447923 | 0.349 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.450213 | 0.347 |
R-HSA-167161 | HIV Transcription Initiation | 0.454724 | 0.342 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.454724 | 0.342 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.454724 | 0.342 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.454724 | 0.342 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.454724 | 0.342 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.454724 | 0.342 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.454724 | 0.342 |
R-HSA-165159 | MTOR signalling | 0.461441 | 0.336 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.461441 | 0.336 |
R-HSA-111996 | Ca-dependent events | 0.461441 | 0.336 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.461441 | 0.336 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.468076 | 0.330 |
R-HSA-5654743 | Signaling by FGFR4 | 0.468076 | 0.330 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.468076 | 0.330 |
R-HSA-8854214 | TBC/RABGAPs | 0.468076 | 0.330 |
R-HSA-9675108 | Nervous system development | 0.469558 | 0.328 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.469930 | 0.328 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.471915 | 0.326 |
R-HSA-2172127 | DAP12 interactions | 0.474630 | 0.324 |
R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.474630 | 0.324 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.480484 | 0.318 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.481104 | 0.318 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.481104 | 0.318 |
R-HSA-1489509 | DAG and IP3 signaling | 0.481104 | 0.318 |
R-HSA-5654741 | Signaling by FGFR3 | 0.481104 | 0.318 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.481104 | 0.318 |
R-HSA-9007101 | Rab regulation of trafficking | 0.481960 | 0.317 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.485933 | 0.313 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 0.487498 | 0.312 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.487498 | 0.312 |
R-HSA-75153 | Apoptotic execution phase | 0.487498 | 0.312 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.489887 | 0.310 |
R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.493814 | 0.306 |
R-HSA-9031628 | NGF-stimulated transcription | 0.500052 | 0.301 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.505512 | 0.296 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 0.512300 | 0.290 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.518312 | 0.285 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.524249 | 0.280 |
R-HSA-6794361 | Neurexins and neuroligins | 0.524249 | 0.280 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.530114 | 0.276 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.530114 | 0.276 |
R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.530114 | 0.276 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.531931 | 0.274 |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.535908 | 0.271 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.541630 | 0.266 |
R-HSA-3214815 | HDACs deacetylate histones | 0.541630 | 0.266 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.541630 | 0.266 |
R-HSA-9843745 | Adipogenesis | 0.543195 | 0.265 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.547281 | 0.262 |
R-HSA-5654736 | Signaling by FGFR1 | 0.547281 | 0.262 |
R-HSA-5578775 | Ion homeostasis | 0.547281 | 0.262 |
R-HSA-75893 | TNF signaling | 0.547281 | 0.262 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.549570 | 0.260 |
R-HSA-112399 | IRS-mediated signalling | 0.552864 | 0.257 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.558378 | 0.253 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.558378 | 0.253 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.563824 | 0.249 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.569204 | 0.245 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.569204 | 0.245 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.569204 | 0.245 |
R-HSA-5358351 | Signaling by Hedgehog | 0.571883 | 0.243 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.574517 | 0.241 |
R-HSA-112043 | PLC beta mediated events | 0.574517 | 0.241 |
R-HSA-450294 | MAP kinase activation | 0.574517 | 0.241 |
R-HSA-9664407 | Parasite infection | 0.578849 | 0.237 |
R-HSA-9664417 | Leishmania phagocytosis | 0.578849 | 0.237 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.578849 | 0.237 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.579765 | 0.237 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.579765 | 0.237 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.579765 | 0.237 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.579765 | 0.237 |
R-HSA-186797 | Signaling by PDGF | 0.579765 | 0.237 |
R-HSA-9707616 | Heme signaling | 0.579765 | 0.237 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.582301 | 0.235 |
R-HSA-8848021 | Signaling by PTK6 | 0.584949 | 0.233 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.584949 | 0.233 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.590069 | 0.229 |
R-HSA-2428924 | IGF1R signaling cascade | 0.590069 | 0.229 |
R-HSA-936837 | Ion transport by P-type ATPases | 0.590069 | 0.229 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.592533 | 0.227 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.595127 | 0.225 |
R-HSA-72312 | rRNA processing | 0.603797 | 0.219 |
R-HSA-112040 | G-protein mediated events | 0.605056 | 0.218 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.605056 | 0.218 |
R-HSA-167172 | Transcription of the HIV genome | 0.609929 | 0.215 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.609929 | 0.215 |
R-HSA-9758941 | Gastrulation | 0.612434 | 0.213 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.619497 | 0.208 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.619497 | 0.208 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.619497 | 0.208 |
R-HSA-448424 | Interleukin-17 signaling | 0.619497 | 0.208 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.624193 | 0.205 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.624193 | 0.205 |
R-HSA-5632684 | Hedgehog 'on' state | 0.624193 | 0.205 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.628832 | 0.201 |
R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.628832 | 0.201 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.637938 | 0.195 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.642408 | 0.192 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.646822 | 0.189 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.651183 | 0.186 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.655490 | 0.183 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.655490 | 0.183 |
R-HSA-9659379 | Sensory processing of sound | 0.659744 | 0.181 |
R-HSA-5688426 | Deubiquitination | 0.662283 | 0.179 |
R-HSA-5654738 | Signaling by FGFR2 | 0.663945 | 0.178 |
R-HSA-9833482 | PKR-mediated signaling | 0.663945 | 0.178 |
R-HSA-5683057 | MAPK family signaling cascades | 0.666588 | 0.176 |
R-HSA-9824446 | Viral Infection Pathways | 0.667480 | 0.176 |
R-HSA-977225 | Amyloid fiber formation | 0.668095 | 0.175 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.679065 | 0.168 |
R-HSA-1640170 | Cell Cycle | 0.682602 | 0.166 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.684192 | 0.165 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.688093 | 0.162 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.690130 | 0.161 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.691946 | 0.160 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.691946 | 0.160 |
R-HSA-438064 | Post NMDA receptor activation events | 0.695752 | 0.158 |
R-HSA-70268 | Pyruvate metabolism | 0.695752 | 0.158 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.698737 | 0.156 |
R-HSA-156902 | Peptide chain elongation | 0.699511 | 0.155 |
R-HSA-9663891 | Selective autophagy | 0.699511 | 0.155 |
R-HSA-5653656 | Vesicle-mediated transport | 0.700415 | 0.155 |
R-HSA-2559583 | Cellular Senescence | 0.706140 | 0.151 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.710514 | 0.148 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.713884 | 0.146 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.714091 | 0.146 |
R-HSA-156842 | Eukaryotic Translation Elongation | 0.717625 | 0.144 |
R-HSA-74752 | Signaling by Insulin receptor | 0.717625 | 0.144 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.721115 | 0.142 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.722691 | 0.141 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.724563 | 0.140 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.727967 | 0.138 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.731330 | 0.136 |
R-HSA-72764 | Eukaryotic Translation Termination | 0.731330 | 0.136 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.731330 | 0.136 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.733706 | 0.134 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.734652 | 0.134 |
R-HSA-190236 | Signaling by FGFR | 0.741173 | 0.130 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.741173 | 0.130 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.741173 | 0.130 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.741173 | 0.130 |
R-HSA-2262752 | Cellular responses to stress | 0.742764 | 0.129 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.745496 | 0.128 |
R-HSA-2408557 | Selenocysteine synthesis | 0.750657 | 0.125 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.750657 | 0.125 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.753741 | 0.123 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.753741 | 0.123 |
R-HSA-1483255 | PI Metabolism | 0.753741 | 0.123 |
R-HSA-192823 | Viral mRNA Translation | 0.756787 | 0.121 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.759795 | 0.119 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.759795 | 0.119 |
R-HSA-111885 | Opioid Signalling | 0.759795 | 0.119 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.765701 | 0.116 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.771463 | 0.113 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.771463 | 0.113 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.771463 | 0.113 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.774291 | 0.111 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.774291 | 0.111 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.774291 | 0.111 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.777083 | 0.110 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.779842 | 0.108 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.779842 | 0.108 |
R-HSA-109582 | Hemostasis | 0.781975 | 0.107 |
R-HSA-6803157 | Antimicrobial peptides | 0.782567 | 0.106 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.785258 | 0.105 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.785258 | 0.105 |
R-HSA-2871796 | FCERI mediated MAPK activation | 0.785258 | 0.105 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.787915 | 0.104 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.793083 | 0.101 |
R-HSA-418990 | Adherens junctions interactions | 0.794133 | 0.100 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.797953 | 0.098 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.798224 | 0.098 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.798224 | 0.098 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.798697 | 0.098 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.800532 | 0.097 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.800722 | 0.097 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.800722 | 0.097 |
R-HSA-373760 | L1CAM interactions | 0.800722 | 0.097 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.808033 | 0.093 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.808033 | 0.093 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.815077 | 0.089 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.815077 | 0.089 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.817368 | 0.088 |
R-HSA-6809371 | Formation of the cornified envelope | 0.819630 | 0.086 |
R-HSA-194138 | Signaling by VEGF | 0.824071 | 0.084 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.827955 | 0.082 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.834704 | 0.078 |
R-HSA-5576891 | Cardiac conduction | 0.838776 | 0.076 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.842057 | 0.075 |
R-HSA-421270 | Cell-cell junction organization | 0.849601 | 0.071 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.852257 | 0.069 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.853400 | 0.069 |
R-HSA-9948299 | Ribosome-associated quality control | 0.854089 | 0.068 |
R-HSA-112316 | Neuronal System | 0.856667 | 0.067 |
R-HSA-1632852 | Macroautophagy | 0.859451 | 0.066 |
R-HSA-8953897 | Cellular responses to stimuli | 0.859515 | 0.066 |
R-HSA-9734767 | Developmental Cell Lineages | 0.866159 | 0.062 |
R-HSA-416476 | G alpha (q) signalling events | 0.867461 | 0.062 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.869593 | 0.061 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.872809 | 0.059 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.877918 | 0.057 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.879007 | 0.056 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.880508 | 0.055 |
R-HSA-1989781 | PPARA activates gene expression | 0.883457 | 0.054 |
R-HSA-446728 | Cell junction organization | 0.884511 | 0.053 |
R-HSA-9612973 | Autophagy | 0.884903 | 0.053 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.886332 | 0.052 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.887744 | 0.052 |
R-HSA-9711097 | Cellular response to starvation | 0.887744 | 0.052 |
R-HSA-9658195 | Leishmania infection | 0.887892 | 0.052 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.887892 | 0.052 |
R-HSA-109581 | Apoptosis | 0.893217 | 0.049 |
R-HSA-2408522 | Selenoamino acid metabolism | 0.895853 | 0.048 |
R-HSA-1266738 | Developmental Biology | 0.899576 | 0.046 |
R-HSA-1483257 | Phospholipid metabolism | 0.902493 | 0.045 |
R-HSA-195721 | Signaling by WNT | 0.905382 | 0.043 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.908094 | 0.042 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.908094 | 0.042 |
R-HSA-1280218 | Adaptive Immune System | 0.915844 | 0.038 |
R-HSA-1500931 | Cell-Cell communication | 0.921113 | 0.036 |
R-HSA-983712 | Ion channel transport | 0.924769 | 0.034 |
R-HSA-388396 | GPCR downstream signalling | 0.930917 | 0.031 |
R-HSA-1474244 | Extracellular matrix organization | 0.932314 | 0.030 |
R-HSA-428157 | Sphingolipid metabolism | 0.935267 | 0.029 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.936869 | 0.028 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.936869 | 0.028 |
R-HSA-5357801 | Programmed Cell Death | 0.939199 | 0.027 |
R-HSA-6805567 | Keratinization | 0.939956 | 0.027 |
R-HSA-5663205 | Infectious disease | 0.943014 | 0.025 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.944307 | 0.025 |
R-HSA-397014 | Muscle contraction | 0.944307 | 0.025 |
R-HSA-73894 | DNA Repair | 0.949854 | 0.022 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.955565 | 0.020 |
R-HSA-8939211 | ESR-mediated signaling | 0.959303 | 0.018 |
R-HSA-157118 | Signaling by NOTCH | 0.960808 | 0.017 |
R-HSA-372790 | Signaling by GPCR | 0.962838 | 0.016 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.966385 | 0.015 |
R-HSA-168256 | Immune System | 0.973568 | 0.012 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.974442 | 0.011 |
R-HSA-1643685 | Disease | 0.980809 | 0.008 |
R-HSA-6798695 | Neutrophil degranulation | 0.982370 | 0.008 |
R-HSA-449147 | Signaling by Interleukins | 0.987346 | 0.006 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.989023 | 0.005 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.991794 | 0.004 |
R-HSA-597592 | Post-translational protein modification | 0.994913 | 0.002 |
R-HSA-168249 | Innate Immune System | 0.994940 | 0.002 |
R-HSA-418594 | G alpha (i) signalling events | 0.995303 | 0.002 |
R-HSA-5668914 | Diseases of metabolism | 0.996357 | 0.002 |
R-HSA-72766 | Translation | 0.996448 | 0.002 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999683 | 0.000 |
R-HSA-382551 | Transport of small molecules | 0.999717 | 0.000 |
R-HSA-392499 | Metabolism of proteins | 0.999937 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999995 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
HIPK2 |
0.838 | 0.758 | 1 | 0.807 |
CDK18 |
0.832 | 0.783 | 1 | 0.827 |
KIS |
0.828 | 0.747 | 1 | 0.742 |
CDK17 |
0.826 | 0.782 | 1 | 0.863 |
CDK19 |
0.826 | 0.768 | 1 | 0.807 |
CDK3 |
0.822 | 0.689 | 1 | 0.855 |
P38G |
0.822 | 0.783 | 1 | 0.871 |
P38D |
0.818 | 0.797 | 1 | 0.856 |
CDK16 |
0.817 | 0.746 | 1 | 0.846 |
CDK7 |
0.817 | 0.746 | 1 | 0.775 |
CDK1 |
0.817 | 0.745 | 1 | 0.812 |
CDK8 |
0.815 | 0.754 | 1 | 0.770 |
JNK2 |
0.813 | 0.783 | 1 | 0.823 |
ERK1 |
0.812 | 0.753 | 1 | 0.803 |
DYRK2 |
0.812 | 0.729 | 1 | 0.717 |
CDK10 |
0.810 | 0.701 | 1 | 0.804 |
HIPK1 |
0.810 | 0.693 | 1 | 0.696 |
CDK5 |
0.810 | 0.725 | 1 | 0.748 |
DYRK4 |
0.809 | 0.722 | 1 | 0.818 |
P38B |
0.809 | 0.764 | 1 | 0.788 |
CDK13 |
0.807 | 0.734 | 1 | 0.797 |
CDK12 |
0.807 | 0.734 | 1 | 0.818 |
CDK14 |
0.805 | 0.743 | 1 | 0.786 |
HIPK4 |
0.804 | 0.580 | 1 | 0.492 |
JNK3 |
0.803 | 0.774 | 1 | 0.791 |
DYRK1B |
0.802 | 0.694 | 1 | 0.775 |
CLK3 |
0.802 | 0.533 | 1 | 0.464 |
CDK9 |
0.802 | 0.728 | 1 | 0.789 |
P38A |
0.794 | 0.729 | 1 | 0.715 |
HIPK3 |
0.794 | 0.664 | 1 | 0.661 |
CDK6 |
0.791 | 0.699 | 1 | 0.801 |
DYRK1A |
0.791 | 0.605 | 1 | 0.671 |
CDK4 |
0.790 | 0.710 | 1 | 0.826 |
SRPK1 |
0.790 | 0.382 | -3 | 0.769 |
ERK2 |
0.788 | 0.719 | 1 | 0.752 |
MAK |
0.785 | 0.515 | -2 | 0.820 |
JNK1 |
0.785 | 0.692 | 1 | 0.827 |
CLK2 |
0.785 | 0.422 | -3 | 0.768 |
NLK |
0.783 | 0.663 | 1 | 0.501 |
DYRK3 |
0.778 | 0.520 | 1 | 0.657 |
CLK1 |
0.776 | 0.406 | -3 | 0.743 |
SRPK2 |
0.775 | 0.298 | -3 | 0.697 |
CDK2 |
0.774 | 0.539 | 1 | 0.685 |
ERK5 |
0.773 | 0.397 | 1 | 0.415 |
CLK4 |
0.771 | 0.374 | -3 | 0.769 |
ICK |
0.768 | 0.394 | -3 | 0.845 |
MOK |
0.766 | 0.464 | 1 | 0.584 |
MTOR |
0.762 | 0.219 | 1 | 0.288 |
CDKL5 |
0.761 | 0.200 | -3 | 0.800 |
PRKD1 |
0.759 | 0.169 | -3 | 0.850 |
SRPK3 |
0.759 | 0.262 | -3 | 0.736 |
NDR2 |
0.758 | 0.130 | -3 | 0.867 |
CDKL1 |
0.754 | 0.170 | -3 | 0.803 |
COT |
0.753 | -0.036 | 2 | 0.805 |
PIM3 |
0.752 | 0.078 | -3 | 0.857 |
PRKD2 |
0.750 | 0.096 | -3 | 0.792 |
PRP4 |
0.750 | 0.414 | -3 | 0.728 |
CDC7 |
0.748 | -0.037 | 1 | 0.135 |
MOS |
0.747 | 0.048 | 1 | 0.170 |
ERK7 |
0.745 | 0.251 | 2 | 0.535 |
RSK2 |
0.745 | 0.080 | -3 | 0.782 |
AURC |
0.744 | 0.060 | -2 | 0.658 |
P90RSK |
0.744 | 0.100 | -3 | 0.786 |
NDR1 |
0.743 | 0.027 | -3 | 0.842 |
PIM1 |
0.741 | 0.088 | -3 | 0.803 |
TBK1 |
0.741 | -0.082 | 1 | 0.080 |
CHAK2 |
0.741 | 0.010 | -1 | 0.603 |
PRPK |
0.740 | -0.021 | -1 | 0.615 |
SKMLCK |
0.740 | 0.033 | -2 | 0.872 |
PKCD |
0.740 | 0.034 | 2 | 0.743 |
ATR |
0.739 | 0.008 | 1 | 0.156 |
NUAK2 |
0.739 | 0.049 | -3 | 0.841 |
MPSK1 |
0.739 | 0.169 | 1 | 0.174 |
RSK3 |
0.739 | 0.039 | -3 | 0.773 |
PKN3 |
0.739 | 0.016 | -3 | 0.828 |
LATS2 |
0.738 | 0.056 | -5 | 0.717 |
GRK1 |
0.738 | 0.044 | -2 | 0.800 |
IKKE |
0.737 | -0.100 | 1 | 0.080 |
MST4 |
0.737 | -0.045 | 2 | 0.806 |
IKKB |
0.736 | -0.108 | -2 | 0.731 |
MAPKAPK3 |
0.736 | 0.024 | -3 | 0.801 |
MAPKAPK2 |
0.735 | 0.045 | -3 | 0.766 |
PKCB |
0.735 | 0.018 | 2 | 0.710 |
PKN2 |
0.735 | -0.029 | -3 | 0.830 |
PKACG |
0.734 | 0.007 | -2 | 0.728 |
WNK1 |
0.734 | -0.078 | -2 | 0.886 |
PKCA |
0.734 | 0.035 | 2 | 0.698 |
RSK4 |
0.733 | 0.084 | -3 | 0.771 |
PKACB |
0.733 | 0.060 | -2 | 0.666 |
CAMK1B |
0.733 | -0.011 | -3 | 0.837 |
MLK2 |
0.733 | -0.014 | 2 | 0.781 |
NIK |
0.732 | -0.008 | -3 | 0.853 |
LATS1 |
0.732 | 0.147 | -3 | 0.878 |
RAF1 |
0.732 | -0.175 | 1 | 0.106 |
IKKA |
0.732 | -0.018 | -2 | 0.724 |
MNK1 |
0.732 | 0.048 | -2 | 0.792 |
GCN2 |
0.731 | -0.169 | 2 | 0.732 |
PHKG1 |
0.731 | -0.010 | -3 | 0.834 |
PRKD3 |
0.731 | 0.040 | -3 | 0.752 |
AMPKA1 |
0.731 | -0.015 | -3 | 0.854 |
TGFBR2 |
0.730 | -0.061 | -2 | 0.734 |
MLK3 |
0.730 | -0.015 | 2 | 0.705 |
AMPKA2 |
0.730 | 0.014 | -3 | 0.828 |
PKCG |
0.730 | 0.003 | 2 | 0.701 |
CAMLCK |
0.730 | 0.010 | -2 | 0.837 |
NEK6 |
0.730 | -0.086 | -2 | 0.794 |
IRE1 |
0.729 | -0.067 | 1 | 0.099 |
BMPR2 |
0.729 | -0.158 | -2 | 0.841 |
GRK7 |
0.729 | 0.033 | 1 | 0.149 |
PKCZ |
0.728 | -0.005 | 2 | 0.748 |
DAPK2 |
0.728 | 0.008 | -3 | 0.849 |
AKT2 |
0.728 | 0.060 | -3 | 0.705 |
PKG2 |
0.728 | 0.031 | -2 | 0.666 |
ULK2 |
0.728 | -0.187 | 2 | 0.735 |
PDHK4 |
0.727 | -0.170 | 1 | 0.169 |
MARK4 |
0.727 | -0.030 | 4 | 0.760 |
MNK2 |
0.727 | -0.030 | -2 | 0.785 |
P70S6KB |
0.726 | 0.001 | -3 | 0.792 |
GRK5 |
0.726 | -0.097 | -3 | 0.826 |
PRKX |
0.725 | 0.060 | -3 | 0.716 |
TSSK1 |
0.725 | 0.018 | -3 | 0.873 |
MLK1 |
0.725 | -0.132 | 2 | 0.766 |
SGK3 |
0.725 | 0.025 | -3 | 0.780 |
GSK3A |
0.724 | 0.186 | 4 | 0.407 |
RIPK3 |
0.724 | -0.144 | 3 | 0.678 |
PAK1 |
0.724 | -0.027 | -2 | 0.796 |
MASTL |
0.724 | -0.057 | -2 | 0.794 |
PAK3 |
0.724 | -0.043 | -2 | 0.790 |
CAMK2D |
0.723 | -0.030 | -3 | 0.836 |
PIM2 |
0.723 | 0.071 | -3 | 0.752 |
IRE2 |
0.723 | -0.031 | 2 | 0.714 |
PAK6 |
0.723 | 0.003 | -2 | 0.706 |
DSTYK |
0.722 | -0.194 | 2 | 0.812 |
NUAK1 |
0.722 | 0.002 | -3 | 0.790 |
PDHK1 |
0.721 | -0.171 | 1 | 0.141 |
BMPR1B |
0.721 | -0.047 | 1 | 0.122 |
NIM1 |
0.721 | -0.076 | 3 | 0.714 |
QSK |
0.720 | 0.004 | 4 | 0.738 |
HUNK |
0.720 | -0.135 | 2 | 0.756 |
PKCH |
0.720 | -0.027 | 2 | 0.687 |
MELK |
0.720 | -0.040 | -3 | 0.806 |
BUB1 |
0.720 | 0.132 | -5 | 0.722 |
AURB |
0.719 | 0.001 | -2 | 0.650 |
MSK2 |
0.719 | -0.006 | -3 | 0.770 |
NEK7 |
0.719 | -0.218 | -3 | 0.808 |
CAMK2A |
0.718 | 0.020 | 2 | 0.675 |
NEK9 |
0.718 | -0.175 | 2 | 0.794 |
DLK |
0.718 | -0.162 | 1 | 0.122 |
TSSK2 |
0.718 | -0.034 | -5 | 0.779 |
CHAK1 |
0.718 | -0.096 | 2 | 0.773 |
BCKDK |
0.717 | -0.163 | -1 | 0.530 |
VRK2 |
0.717 | 0.083 | 1 | 0.204 |
AKT1 |
0.717 | 0.033 | -3 | 0.729 |
MSK1 |
0.717 | 0.017 | -3 | 0.771 |
SMG1 |
0.716 | -0.066 | 1 | 0.138 |
CAMK2G |
0.716 | -0.146 | 2 | 0.695 |
ULK1 |
0.716 | -0.187 | -3 | 0.765 |
MST3 |
0.716 | -0.023 | 2 | 0.808 |
WNK3 |
0.716 | -0.232 | 1 | 0.097 |
DNAPK |
0.716 | -0.048 | 1 | 0.140 |
PKCT |
0.715 | -0.022 | 2 | 0.696 |
YSK4 |
0.715 | -0.094 | 1 | 0.090 |
DCAMKL1 |
0.715 | 0.001 | -3 | 0.801 |
CAMK4 |
0.715 | -0.084 | -3 | 0.815 |
PASK |
0.715 | 0.095 | -3 | 0.875 |
SIK |
0.714 | -0.021 | -3 | 0.766 |
PINK1 |
0.713 | 0.107 | 1 | 0.319 |
AKT3 |
0.713 | 0.056 | -3 | 0.664 |
ALK4 |
0.713 | -0.069 | -2 | 0.786 |
PKR |
0.713 | -0.099 | 1 | 0.120 |
MLK4 |
0.713 | -0.100 | 2 | 0.682 |
CK1E |
0.712 | 0.013 | -3 | 0.587 |
RIPK1 |
0.712 | -0.215 | 1 | 0.094 |
TAO3 |
0.712 | -0.014 | 1 | 0.137 |
QIK |
0.712 | -0.094 | -3 | 0.822 |
PKCE |
0.712 | 0.025 | 2 | 0.697 |
TTBK2 |
0.712 | -0.168 | 2 | 0.659 |
BRSK2 |
0.711 | -0.048 | -3 | 0.813 |
PAK2 |
0.711 | -0.059 | -2 | 0.775 |
PKACA |
0.711 | 0.030 | -2 | 0.619 |
NEK2 |
0.711 | -0.137 | 2 | 0.783 |
BRSK1 |
0.710 | -0.033 | -3 | 0.800 |
GRK6 |
0.710 | -0.153 | 1 | 0.117 |
TGFBR1 |
0.710 | -0.074 | -2 | 0.763 |
MARK3 |
0.709 | -0.027 | 4 | 0.694 |
CAMK2B |
0.709 | -0.047 | 2 | 0.642 |
ANKRD3 |
0.709 | -0.213 | 1 | 0.119 |
PKCI |
0.709 | -0.024 | 2 | 0.716 |
IRAK4 |
0.709 | -0.108 | 1 | 0.075 |
MYLK4 |
0.708 | -0.037 | -2 | 0.777 |
GRK4 |
0.708 | -0.155 | -2 | 0.801 |
CHK1 |
0.708 | 0.012 | -3 | 0.830 |
ATM |
0.707 | -0.113 | 1 | 0.124 |
TLK2 |
0.707 | -0.103 | 1 | 0.091 |
MEK1 |
0.706 | -0.146 | 2 | 0.768 |
PAK5 |
0.706 | -0.028 | -2 | 0.647 |
MAPKAPK5 |
0.705 | -0.064 | -3 | 0.737 |
SSTK |
0.705 | -0.007 | 4 | 0.726 |
CK1D |
0.705 | 0.035 | -3 | 0.543 |
GSK3B |
0.704 | 0.044 | 4 | 0.403 |
DRAK1 |
0.704 | -0.138 | 1 | 0.111 |
SGK1 |
0.704 | 0.058 | -3 | 0.643 |
PHKG2 |
0.704 | -0.063 | -3 | 0.779 |
PAK4 |
0.704 | -0.016 | -2 | 0.655 |
MAP3K15 |
0.704 | -0.010 | 1 | 0.108 |
MEK5 |
0.703 | -0.132 | 2 | 0.768 |
AURA |
0.703 | -0.029 | -2 | 0.622 |
SBK |
0.703 | 0.142 | -3 | 0.599 |
LKB1 |
0.703 | -0.003 | -3 | 0.816 |
KHS1 |
0.703 | 0.029 | 1 | 0.108 |
GCK |
0.703 | -0.015 | 1 | 0.124 |
PKN1 |
0.703 | -0.007 | -3 | 0.730 |
PBK |
0.703 | 0.025 | 1 | 0.145 |
P70S6K |
0.702 | -0.012 | -3 | 0.712 |
CAMK1G |
0.702 | -0.051 | -3 | 0.759 |
ACVR2B |
0.702 | -0.116 | -2 | 0.741 |
ZAK |
0.702 | -0.148 | 1 | 0.098 |
GRK2 |
0.702 | -0.071 | -2 | 0.693 |
NEK5 |
0.702 | -0.126 | 1 | 0.095 |
MEKK1 |
0.702 | -0.126 | 1 | 0.108 |
PDK1 |
0.702 | -0.017 | 1 | 0.138 |
CK1G1 |
0.702 | -0.019 | -3 | 0.570 |
HASPIN |
0.702 | 0.021 | -1 | 0.515 |
ACVR2A |
0.702 | -0.117 | -2 | 0.725 |
WNK4 |
0.701 | -0.140 | -2 | 0.865 |
PLK4 |
0.701 | -0.148 | 2 | 0.556 |
ROCK2 |
0.700 | 0.037 | -3 | 0.801 |
MEKK6 |
0.700 | -0.052 | 1 | 0.109 |
MARK2 |
0.700 | -0.057 | 4 | 0.651 |
MEKK2 |
0.700 | -0.127 | 2 | 0.754 |
TNIK |
0.700 | -0.009 | 3 | 0.854 |
DCAMKL2 |
0.700 | -0.048 | -3 | 0.804 |
PERK |
0.699 | -0.144 | -2 | 0.783 |
SNRK |
0.699 | -0.147 | 2 | 0.614 |
HGK |
0.699 | -0.035 | 3 | 0.849 |
NEK11 |
0.698 | -0.120 | 1 | 0.132 |
TAO2 |
0.698 | -0.055 | 2 | 0.800 |
LOK |
0.698 | -0.032 | -2 | 0.746 |
GAK |
0.698 | -0.019 | 1 | 0.169 |
KHS2 |
0.698 | 0.004 | 1 | 0.125 |
HPK1 |
0.698 | -0.052 | 1 | 0.125 |
CK1A2 |
0.696 | -0.003 | -3 | 0.543 |
PLK1 |
0.696 | -0.202 | -2 | 0.727 |
SMMLCK |
0.695 | -0.041 | -3 | 0.804 |
MRCKB |
0.695 | 0.007 | -3 | 0.740 |
SLK |
0.695 | -0.027 | -2 | 0.694 |
ALK2 |
0.694 | -0.126 | -2 | 0.765 |
DAPK3 |
0.694 | -0.017 | -3 | 0.808 |
MARK1 |
0.694 | -0.085 | 4 | 0.713 |
BMPR1A |
0.694 | -0.096 | 1 | 0.111 |
MRCKA |
0.693 | 0.011 | -3 | 0.759 |
HRI |
0.693 | -0.198 | -2 | 0.794 |
MINK |
0.693 | -0.092 | 1 | 0.090 |
MEKK3 |
0.692 | -0.210 | 1 | 0.114 |
LRRK2 |
0.692 | -0.010 | 2 | 0.791 |
CHK2 |
0.691 | 0.000 | -3 | 0.654 |
CAMK1D |
0.691 | -0.017 | -3 | 0.707 |
FAM20C |
0.691 | -0.093 | 2 | 0.479 |
NEK4 |
0.690 | -0.146 | 1 | 0.083 |
BRAF |
0.690 | -0.185 | -4 | 0.758 |
DMPK1 |
0.690 | 0.057 | -3 | 0.760 |
NEK8 |
0.689 | -0.174 | 2 | 0.776 |
CRIK |
0.688 | 0.045 | -3 | 0.735 |
AAK1 |
0.687 | 0.055 | 1 | 0.175 |
CAMKK2 |
0.687 | -0.126 | -2 | 0.742 |
GRK3 |
0.687 | -0.075 | -2 | 0.652 |
DAPK1 |
0.687 | -0.027 | -3 | 0.789 |
TLK1 |
0.686 | -0.180 | -2 | 0.786 |
NEK1 |
0.686 | -0.122 | 1 | 0.077 |
PLK3 |
0.686 | -0.172 | 2 | 0.660 |
EEF2K |
0.685 | -0.074 | 3 | 0.796 |
MST2 |
0.685 | -0.129 | 1 | 0.102 |
CAMK1A |
0.685 | -0.005 | -3 | 0.671 |
YSK1 |
0.685 | -0.096 | 2 | 0.778 |
TTBK1 |
0.684 | -0.173 | 2 | 0.581 |
CAMKK1 |
0.684 | -0.202 | -2 | 0.738 |
PKG1 |
0.683 | -0.024 | -2 | 0.582 |
ROCK1 |
0.682 | -0.004 | -3 | 0.757 |
VRK1 |
0.682 | -0.152 | 2 | 0.796 |
MST1 |
0.681 | -0.110 | 1 | 0.090 |
BIKE |
0.681 | -0.013 | 1 | 0.164 |
CK2A2 |
0.680 | -0.098 | 1 | 0.113 |
TAK1 |
0.680 | -0.187 | 1 | 0.092 |
LIMK2_TYR |
0.680 | 0.210 | -3 | 0.865 |
PDHK3_TYR |
0.679 | 0.208 | 4 | 0.820 |
IRAK1 |
0.678 | -0.248 | -1 | 0.514 |
STK33 |
0.678 | -0.141 | 2 | 0.548 |
OSR1 |
0.676 | -0.070 | 2 | 0.749 |
MYO3B |
0.676 | -0.050 | 2 | 0.797 |
TAO1 |
0.675 | -0.072 | 1 | 0.100 |
ASK1 |
0.675 | -0.062 | 1 | 0.108 |
NEK3 |
0.674 | -0.135 | 1 | 0.100 |
TESK1_TYR |
0.673 | 0.132 | 3 | 0.842 |
CK2A1 |
0.672 | -0.101 | 1 | 0.108 |
PKMYT1_TYR |
0.672 | 0.185 | 3 | 0.807 |
PDHK4_TYR |
0.670 | 0.099 | 2 | 0.795 |
MYO3A |
0.669 | -0.085 | 1 | 0.107 |
MEK2 |
0.668 | -0.207 | 2 | 0.753 |
CK1A |
0.668 | -0.013 | -3 | 0.458 |
MAP2K4_TYR |
0.667 | 0.063 | -1 | 0.611 |
TTK |
0.667 | -0.099 | -2 | 0.759 |
RIPK2 |
0.667 | -0.237 | 1 | 0.080 |
YANK3 |
0.665 | -0.042 | 2 | 0.339 |
MAP2K6_TYR |
0.664 | 0.027 | -1 | 0.608 |
PLK2 |
0.662 | -0.112 | -3 | 0.709 |
MAP2K7_TYR |
0.661 | -0.053 | 2 | 0.785 |
LIMK1_TYR |
0.660 | 0.031 | 2 | 0.799 |
RET |
0.659 | -0.078 | 1 | 0.121 |
PDHK1_TYR |
0.659 | -0.046 | -1 | 0.604 |
PINK1_TYR |
0.658 | -0.122 | 1 | 0.163 |
TNK1 |
0.658 | 0.013 | 3 | 0.750 |
ALPHAK3 |
0.657 | -0.111 | -1 | 0.504 |
CSF1R |
0.656 | -0.045 | 3 | 0.757 |
ABL2 |
0.656 | -0.048 | -1 | 0.538 |
JAK1 |
0.656 | -0.009 | 1 | 0.100 |
BMPR2_TYR |
0.656 | -0.054 | -1 | 0.576 |
ROS1 |
0.656 | -0.046 | 3 | 0.728 |
NEK10_TYR |
0.655 | -0.062 | 1 | 0.103 |
JAK2 |
0.655 | -0.052 | 1 | 0.125 |
MST1R |
0.654 | -0.085 | 3 | 0.776 |
TNNI3K_TYR |
0.654 | 0.005 | 1 | 0.130 |
FGR |
0.653 | -0.028 | 1 | 0.102 |
TYRO3 |
0.653 | -0.110 | 3 | 0.769 |
ABL1 |
0.653 | -0.058 | -1 | 0.538 |
TNK2 |
0.653 | -0.056 | 3 | 0.712 |
TXK |
0.652 | -0.077 | 1 | 0.108 |
TYK2 |
0.651 | -0.144 | 1 | 0.104 |
YES1 |
0.651 | -0.068 | -1 | 0.627 |
STLK3 |
0.648 | -0.180 | 1 | 0.081 |
LCK |
0.648 | -0.084 | -1 | 0.573 |
EPHB4 |
0.647 | -0.122 | -1 | 0.525 |
EPHA6 |
0.647 | -0.126 | -1 | 0.536 |
DDR1 |
0.646 | -0.114 | 4 | 0.757 |
JAK3 |
0.646 | -0.132 | 1 | 0.117 |
BLK |
0.644 | -0.092 | -1 | 0.565 |
KDR |
0.643 | -0.086 | 3 | 0.702 |
ITK |
0.642 | -0.142 | -1 | 0.539 |
HCK |
0.642 | -0.142 | -1 | 0.570 |
KIT |
0.642 | -0.113 | 3 | 0.755 |
MET |
0.641 | -0.093 | 3 | 0.756 |
FGFR2 |
0.641 | -0.081 | 3 | 0.730 |
FGFR1 |
0.641 | -0.055 | 3 | 0.706 |
TEK |
0.640 | -0.039 | 3 | 0.692 |
DDR2 |
0.639 | -0.008 | 3 | 0.667 |
WEE1_TYR |
0.639 | -0.089 | -1 | 0.518 |
FER |
0.639 | -0.173 | 1 | 0.112 |
PDGFRB |
0.638 | -0.183 | 3 | 0.760 |
BMX |
0.638 | -0.124 | -1 | 0.478 |
MERTK |
0.638 | -0.143 | 3 | 0.732 |
INSRR |
0.638 | -0.152 | 3 | 0.692 |
AXL |
0.637 | -0.158 | 3 | 0.726 |
FLT3 |
0.636 | -0.175 | 3 | 0.766 |
FYN |
0.635 | -0.088 | -1 | 0.576 |
CK1G3 |
0.635 | -0.042 | -3 | 0.414 |
PDGFRA |
0.634 | -0.164 | 3 | 0.765 |
SRMS |
0.634 | -0.189 | 1 | 0.092 |
TEC |
0.633 | -0.160 | -1 | 0.492 |
ALK |
0.632 | -0.136 | 3 | 0.666 |
EPHB1 |
0.632 | -0.198 | 1 | 0.094 |
YANK2 |
0.631 | -0.067 | 2 | 0.347 |
EPHA4 |
0.631 | -0.126 | 2 | 0.664 |
EPHB3 |
0.630 | -0.180 | -1 | 0.508 |
FGFR3 |
0.630 | -0.099 | 3 | 0.699 |
BTK |
0.629 | -0.222 | -1 | 0.533 |
PTK2B |
0.629 | -0.095 | -1 | 0.524 |
FLT1 |
0.628 | -0.156 | -1 | 0.521 |
EPHB2 |
0.627 | -0.189 | -1 | 0.498 |
FRK |
0.627 | -0.166 | -1 | 0.547 |
MATK |
0.627 | -0.108 | -1 | 0.483 |
PTK6 |
0.627 | -0.184 | -1 | 0.515 |
LTK |
0.626 | -0.168 | 3 | 0.683 |
SRC |
0.626 | -0.114 | -1 | 0.578 |
NTRK3 |
0.626 | -0.131 | -1 | 0.520 |
EPHA1 |
0.626 | -0.163 | 3 | 0.734 |
ERBB2 |
0.624 | -0.181 | 1 | 0.103 |
ZAP70 |
0.624 | -0.028 | -1 | 0.435 |
LYN |
0.624 | -0.146 | 3 | 0.670 |
MUSK |
0.623 | -0.128 | 1 | 0.069 |
INSR |
0.623 | -0.167 | 3 | 0.678 |
EGFR |
0.621 | -0.127 | 1 | 0.082 |
NTRK2 |
0.621 | -0.211 | 3 | 0.702 |
FLT4 |
0.621 | -0.185 | 3 | 0.687 |
EPHA7 |
0.621 | -0.169 | 2 | 0.673 |
NTRK1 |
0.621 | -0.215 | -1 | 0.549 |
FGFR4 |
0.618 | -0.124 | -1 | 0.492 |
SYK |
0.617 | -0.099 | -1 | 0.478 |
CK1G2 |
0.617 | -0.048 | -3 | 0.497 |
EPHA3 |
0.617 | -0.176 | 2 | 0.641 |
PTK2 |
0.615 | -0.096 | -1 | 0.491 |
CSK |
0.614 | -0.170 | 2 | 0.681 |
EPHA8 |
0.614 | -0.156 | -1 | 0.494 |
ERBB4 |
0.611 | -0.112 | 1 | 0.091 |
EPHA5 |
0.609 | -0.190 | 2 | 0.639 |
IGF1R |
0.605 | -0.165 | 3 | 0.615 |
EPHA2 |
0.603 | -0.167 | -1 | 0.456 |
FES |
0.596 | -0.164 | -1 | 0.470 |