Motif 174 (n=168)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0A6YYC7 | ZFP91-CNTF | S83 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 91 homolog) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000256|ARBA:ARBA00054990}. |
| A0A0C4DFX4 | None | S1682 | ochoa | Snf2 related CREBBP activator protein | None |
| A6H8Y1 | BDP1 | S33 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6NJZ7 | RIMBP3C | S314 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NNM3 | RIMBP3B | S314 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A7E2V4 | ZSWIM8 | S1092 | ochoa | Zinc finger SWIM domain-containing protein 8 | Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}. |
| A7MCY6 | TBKBP1 | S342 | ochoa | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}. |
| E9PAV3 | NACA | S802 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| K7ELQ4 | ATF7-NPFF | S311 | ochoa | ATF7-NPFF readthrough | None |
| O00499 | BIN1 | S298 | ochoa | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:24755653, ECO:0000269|PubMed:27179792, ECO:0000269|PubMed:28893863, ECO:0000269|PubMed:8782822}. |
| O14497 | ARID1A | S233 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14497 | ARID1A | S1600 | ochoa | AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| O14686 | KMT2D | S4011 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15047 | SETD1A | S1103 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
| O15063 | GARRE1 | S723 | ochoa | Granule associated Rac and RHOG effector protein 1 (GARRE1) | Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067). {ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:31871319}. |
| O15164 | TRIM24 | S667 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15265 | ATXN7 | S302 | ochoa | Ataxin-7 (Spinocerebellar ataxia type 7 protein) | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}. |
| O15417 | TNRC18 | S1232 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O60244 | MED14 | S1119 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60292 | SIPA1L3 | S1692 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60303 | KATNIP | S758 | ochoa | Katanin-interacting protein | May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269|PubMed:26714646}. |
| O60885 | BRD4 | S470 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
| O75052 | NOS1AP | S266 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75113 | N4BP1 | S562 | ochoa | NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-) | Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity (PubMed:31133753). Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250|UniProtKB:Q6A037, ECO:0000269|PubMed:31133753}. |
| O75128 | COBL | S917 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
| O75154 | RAB11FIP3 | S102 | ochoa|psp | Rab11 family-interacting protein 3 (FIP3) (FIP3-Rab11) (Rab11-FIP3) (Arfophilin-1) (EF hands-containing Rab-interacting protein) (Eferin) (MU-MB-17.148) | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867). {ECO:0000250|UniProtKB:Q8CHD8, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:16148947, ECO:0000269|PubMed:17394487, ECO:0000269|PubMed:17628206, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19327867, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26258637, ECO:0000269|PubMed:31204173}. |
| O76080 | ZFAND5 | S128 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94842 | TOX4 | S315 | ochoa | TOX high mobility group box family member 4 | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}. |
| O94868 | FCHSD2 | S700 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O95359 | TACC2 | S1025 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| P08651 | NFIC | S427 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P08651 | NFIC | S477 | ochoa | Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
| P10242 | MYB | S463 | ochoa | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P12755 | SKI | S404 | ochoa | Ski oncogene (Proto-oncogene c-Ski) | May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}. |
| P19532 | TFE3 | S149 | ochoa | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
| P25054 | APC | S2789 | ochoa|psp | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P28324 | ELK4 | S180 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P29353 | SHC1 | S54 | psp | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30291 | WEE1 | S67 | ochoa|psp | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269|PubMed:15070733, ECO:0000269|PubMed:7743995, ECO:0000269|PubMed:8348613, ECO:0000269|PubMed:8428596}. |
| P41182 | BCL6 | S343 | ochoa|psp | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651, ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:9649500}. |
| P42226 | STAT6 | S707 | psp | Signal transducer and activator of transcription 6 (IL-4 Stat) | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}. |
| P43364 | MAGEA11 | S181 | psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P46821 | MAP1B | S1620 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S380 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49848 | TAF6 | S636 | ochoa | Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}. |
| P50549 | ETV1 | S146 | psp | ETS translocation variant 1 (Ets-related protein 81) | Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}. |
| P51825 | AFF1 | S588 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52948 | NUP98 | S1099 | ochoa | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
| P54259 | ATN1 | S355 | ochoa | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P56645 | PER3 | S994 | ochoa | Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3) | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269|PubMed:17346965, ECO:0000269|PubMed:19716732, ECO:0000269|PubMed:24439663, ECO:0000269|PubMed:24577121, ECO:0000269|PubMed:26903630}. |
| P78325 | ADAM8 | S758 | ochoa | Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) | Possible involvement in extravasation of leukocytes. |
| P78559 | MAP1A | S1762 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q03431 | PTH1R | S504 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
| Q05209 | PTPN12 | S369 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07889 | SOS1 | S1193 | psp | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q08AD1 | CAMSAP2 | S970 | ochoa | Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28726242}. |
| Q09666 | AHNAK | S4908 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12774 | ARHGEF5 | S521 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12778 | FOXO1 | S22 | psp | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (By similarity). Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (PubMed:17024043). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (PubMed:19483080). Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). {ECO:0000250|UniProtKB:A4L7N3, ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:17024043, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:19483080, ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:31063815}. |
| Q12968 | NFATC3 | S269 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13459 | MYO9B | S1122 | ochoa | Unconventional myosin-IXb (Unconventional myosin-9b) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). {ECO:0000269|PubMed:26529257, ECO:0000269|PubMed:9490638}. |
| Q13470 | TNK1 | S546 | ochoa | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q13495 | MAMLD1 | S676 | ochoa | Mastermind-like domain-containing protein 1 (F18) (Protein CG1) | Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. {ECO:0000269|PubMed:18162467}. |
| Q13671 | RIN1 | S210 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q14155 | ARHGEF7 | S599 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14188 | TFDP2 | S42 | ochoa | Transcription factor Dp-2 (E2F dimerization partner 2) | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000305|PubMed:20176812}. |
| Q14451 | GRB7 | S76 | ochoa | Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}. |
| Q14679 | TTLL4 | S1143 | ochoa | Tubulin monoglutamylase TTLL4 (EC 6.3.2.-) (Protein monoglutamylase TTLL4) (Tubulin--tyrosine ligase-like protein 4) | Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}. |
| Q16584 | MAP3K11 | S740 | ochoa | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16643 | DBN1 | S312 | ochoa | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
| Q16799 | RTN1 | S560 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2NL68 | PROSER3 | T363 | ochoa | Proline and serine-rich protein 3 | None |
| Q4AC94 | C2CD3 | S772 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4KMP7 | TBC1D10B | S661 | ochoa | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
| Q5JRC9 | FAM47A | S542 | ochoa | Protein FAM47A | None |
| Q5JYT7 | KIAA1755 | S463 | ochoa | Uncharacterized protein KIAA1755 | None |
| Q5T1R4 | HIVEP3 | S2067 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T7N3 | KANK4 | S92 | ochoa | KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38) | May be involved in the control of cytoskeleton formation by regulating actin polymerization. {ECO:0000269|PubMed:17996375}. |
| Q5VY43 | PEAR1 | S1009 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q641Q2 | WASHC2A | S704 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q68CZ2 | TNS3 | S660 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68EM7 | ARHGAP17 | S570 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6BEB4 | SP5 | S126 | ochoa | Transcription factor Sp5 | Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}. |
| Q6NTE8 | MRNIP | S217 | ochoa | MRN complex-interacting protein (MRN-interacting protein) | Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553). |
| Q6NUJ5 | PWWP2B | S84 | ochoa | PWWP domain-containing protein 2B | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:30228260}. |
| Q6NV74 | CRACDL | T338 | ochoa | CRACD-like protein | None |
| Q6P1J9 | CDC73 | S345 | ochoa | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}. |
| Q6ZRS2 | SRCAP | S1859 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q6ZSZ5 | ARHGEF18 | S146 | ochoa | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:28132693}. |
| Q6ZSZ6 | TSHZ1 | S489 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q7Z2Z1 | TICRR | S1141 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6B7 | SRGAP1 | S835 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
| Q86U44 | METTL3 | S50 | ochoa|psp | N(6)-adenosine-methyltransferase catalytic subunit METTL3 (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N(6)-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27281194, PubMed:27373337, PubMed:27627798, PubMed:28297716, PubMed:29348140, PubMed:29506078, PubMed:30428350, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616). M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). Also required for oogenesis (By similarity). Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716). M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity). Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702). During human coronavirus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823). {ECO:0000250|UniProtKB:Q8C3P7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26321680, ECO:0000269|PubMed:26593424, ECO:0000269|PubMed:27117702, ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:27627798, ECO:0000269|PubMed:28297716, ECO:0000269|PubMed:28637692, ECO:0000269|PubMed:29348140, ECO:0000269|PubMed:29506078, ECO:0000269|PubMed:30428350, ECO:0000269|PubMed:30559377, ECO:0000269|PubMed:33961823, ECO:0000269|PubMed:9409616}. |
| Q86XN7 | PROSER1 | S269 | ochoa | Proline and serine-rich protein 1 | Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs). {ECO:0000269|PubMed:34667079}. |
| Q86YC2 | PALB2 | S792 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IV32 | CCDC71 | S97 | ochoa | Coiled-coil domain-containing protein 71 | None |
| Q8IVF2 | AHNAK2 | S56 | ochoa | Protein AHNAK2 | None |
| Q8IY33 | MICALL2 | S153 | ochoa | MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) | Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}. |
| Q8IZ21 | PHACTR4 | S342 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZP0 | ABI1 | S216 | ochoa|psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8IZP0 | ABI1 | S267 | psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N1G1 | REXO1 | S365 | ochoa | RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin-A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1) | Seems to have no detectable effect on transcription elongation in vitro. {ECO:0000269|PubMed:12943681}. |
| Q8N3F8 | MICALL1 | S621 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S640 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3L3 | TXLNB | S554 | ochoa | Beta-taxilin (Muscle-derived protein 77) (hMDP77) | Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}. |
| Q8N4C8 | MINK1 | S601 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N4L2 | PIP4P2 | S33 | ochoa | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q9CZX7, ECO:0000269|PubMed:16365287}. |
| Q8N5F7 | NKAP | S149 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
| Q8NCD3 | HJURP | S185 | ochoa|psp | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}. |
| Q8NEZ4 | KMT2C | S1947 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TAP9 | MPLKIP | S47 | ochoa | M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
| Q8TD19 | NEK9 | S869 | ochoa|psp | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Q8TD55 | PLEKHO2 | S356 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TDZ2 | MICAL1 | S774 | ochoa | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}. |
| Q8TDZ2 | MICAL1 | S810 | ochoa | [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250|UniProtKB:Q8VDP3, ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000269|PubMed:26845023, ECO:0000269|PubMed:28230050, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:32344433, ECO:0000305|PubMed:27552051}. |
| Q8WXF1 | PSPC1 | S477 | ochoa | Paraspeckle component 1 (Paraspeckle protein 1) | RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}. |
| Q92530 | PSMF1 | S153 | ochoa | Proteasome inhibitor PI31 subunit (hPI31) | Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. {ECO:0000269|PubMed:10764772}. |
| Q92574 | TSC1 | S584 | ochoa|psp | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
| Q92615 | LARP4B | S718 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92993 | KAT5 | S90 | ochoa|psp | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (Protein lactyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4 (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756, PubMed:16387653, PubMed:19909775, PubMed:25865756, PubMed:27153538, PubMed:29174981, PubMed:29335245, PubMed:32822602, PubMed:33076429). Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription (PubMed:12776177, PubMed:14966270, PubMed:15042092, PubMed:15121871, PubMed:15310756). The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:17709392, PubMed:19783983, PubMed:32832608). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks (PubMed:27153538, PubMed:32832608). Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (PubMed:17709392, PubMed:26438602). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes (By similarity). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer (PubMed:16141325, PubMed:17189187, PubMed:17360565, PubMed:17996965, PubMed:24835996, PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:30704899, PubMed:31857589, PubMed:32034146, PubMed:32817552, PubMed:34077757). Directly acetylates and activates ATM (PubMed:16141325). Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex (PubMed:32034146). Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (PubMed:17996965). Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity (PubMed:17360565, PubMed:24835996). Involved in skeletal myoblast differentiation by mediating acetylation of SOX4 (PubMed:26291311). Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (PubMed:33938178). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation (PubMed:32817552). Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1 (PubMed:34077757). Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase (PubMed:34077757). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively (PubMed:29192674, PubMed:34608293, PubMed:38961290). Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins (PubMed:26829474, PubMed:29040603, PubMed:30409912, PubMed:34608293). Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis (PubMed:26829474). Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes (PubMed:29040603). Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment (PubMed:30409912). Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:12776177, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15042092, ECO:0000269|PubMed:15121871, ECO:0000269|PubMed:15310756, ECO:0000269|PubMed:16141325, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17709392, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:19783983, ECO:0000269|PubMed:19909775, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:26438602, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:29174981, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32822602, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:33076429, ECO:0000269|PubMed:33938178, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:38961290}.; FUNCTION: (Microbial infection) Catalyzes the acetylation of flavivirus NS3 protein to modulate their RNA-binding and -unwinding activities leading to facilitate viral replication. {ECO:0000269|PubMed:37478852}. |
| Q93052 | LPP | S151 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969V6 | MRTFA | S785 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AY4 | TTC28 | S2302 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96H55 | MYO19 | Y687 | ochoa | Unconventional myosin-XIX (Myosin head domain-containing protein 1) | Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824). {ECO:0000250|UniProtKB:Q5SV80, ECO:0000269|PubMed:19932026, ECO:0000269|PubMed:25447992, ECO:0000305|PubMed:23568824}. |
| Q96JP5 | ZFP91 | S83 | ochoa | E3 ubiquitin-protein ligase ZFP91 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZFP91) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91) | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}. |
| Q96L73 | NSD1 | S2369 | ochoa | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) | Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. {ECO:0000269|PubMed:21196496}. |
| Q96LL9 | DNAJC30 | S137 | ochoa | DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein) | Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). May be a chaperone protein involved in the turnover of the subunits of mitochondrial complex I N-module. It facilitates the degradation of N-module subunits damaged by oxidative stress, and contributes to complex I functional efficiency (PubMed:33465056). {ECO:0000250|UniProtKB:P59041, ECO:0000269|PubMed:33465056}. |
| Q96PE2 | ARHGEF17 | S147 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QC0 | PPP1R10 | S320 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96RY5 | CRAMP1 | S596 | ochoa | Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) | None |
| Q99700 | ATXN2 | S565 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99700 | ATXN2 | S1213 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BUG6 | ZSCAN5A | S335 | ochoa | Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) | May be involved in transcriptional regulation. |
| Q9BUR4 | WRAP53 | S26 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BVI0 | PHF20 | S880 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
| Q9BXK1 | KLF16 | S226 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9BY89 | KIAA1671 | S92 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S986 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C0B0 | UNK | S336 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
| Q9C0C9 | UBE2O | S1240 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0E4 | GRIP2 | S824 | ochoa | Glutamate receptor-interacting protein 2 (GRIP-2) | May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000250}. |
| Q9C0J8 | WDR33 | S1210 | ochoa | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. {ECO:0000269|PubMed:19217410}. |
| Q9H5J0 | ZBTB3 | S228 | ochoa | Zinc finger and BTB domain-containing protein 3 | May be involved in transcriptional regulation. |
| Q9H6K5 | PRR36 | S173 | ochoa | Proline-rich protein 36 | None |
| Q9H7P9 | PLEKHG2 | S1049 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H987 | SYNPO2L | S790 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HCM1 | RESF1 | S221 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NQC3 | RTN4 | S124 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9P1Y5 | CAMSAP3 | S780 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P1Y5 | CAMSAP3 | S814 | ochoa | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}. |
| Q9P202 | WHRN | S245 | ochoa | Whirlin (Autosomal recessive deafness type 31 protein) | Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}. |
| Q9P202 | WHRN | S685 | ochoa | Whirlin (Autosomal recessive deafness type 31 protein) | Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q80VW5}. |
| Q9UBW7 | ZMYM2 | S305 | ochoa|psp | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | Involved in the negative regulation of transcription. {ECO:0000269|PubMed:32891193}. |
| Q9UFD9 | RIMBP3 | S314 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UKL3 | CASP8AP2 | S858 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UMS6 | SYNPO2 | S902 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPN4 | CEP131 | S21 | ochoa|psp | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPQ9 | TNRC6B | S61 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPW6 | SATB2 | S20 | ochoa | DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Q9UQC2 | GAB2 | Y491 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
| Q9UQF2 | MAPK8IP1 | S341 | psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y228 | TRAF3IP3 | S111 | ochoa | TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3) | Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}. |
| Q9Y2H5 | PLEKHA6 | Y365 | ochoa | Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) | None |
| Q9Y3Q8 | TSC22D4 | S165 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y3Q8 | TSC22D4 | S190 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y6A5 | TACC3 | S250 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q9Y6N7 | ROBO1 | S1492 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| Q9NRF2 | SH2B1 | Y494 | GPS6 | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity). {ECO:0000250|UniProtKB:Q91ZM2, ECO:0000269|PubMed:11827956, ECO:0000269|PubMed:14565960, ECO:0000269|PubMed:15767667, ECO:0000269|PubMed:16569669, ECO:0000269|PubMed:17471236, ECO:0000269|PubMed:9694882, ECO:0000269|PubMed:9742218}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.000034 | 4.464 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.000013 | 4.896 |
| R-HSA-9842663 | Signaling by LTK | 0.000034 | 4.464 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.000057 | 4.244 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.000089 | 4.049 |
| R-HSA-8853659 | RET signaling | 0.000130 | 3.885 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000250 | 3.601 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000314 | 3.502 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.000431 | 3.366 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.000542 | 3.266 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.000661 | 3.180 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.000796 | 3.099 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.000796 | 3.099 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.000741 | 3.130 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.001305 | 2.885 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.001326 | 2.877 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.001305 | 2.885 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.001409 | 2.851 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.001814 | 2.741 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.001961 | 2.708 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.002235 | 2.651 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.002235 | 2.651 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.002277 | 2.643 |
| R-HSA-210993 | Tie2 Signaling | 0.002235 | 2.651 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.002115 | 2.675 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.002245 | 2.649 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.003152 | 2.501 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.003501 | 2.456 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.003501 | 2.456 |
| R-HSA-4839726 | Chromatin organization | 0.003274 | 2.485 |
| R-HSA-73887 | Death Receptor Signaling | 0.003247 | 2.489 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.003669 | 2.435 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.004269 | 2.370 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.004688 | 2.329 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.006092 | 2.215 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.005599 | 2.252 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.006156 | 2.211 |
| R-HSA-177929 | Signaling by EGFR | 0.005835 | 2.234 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.006092 | 2.215 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.008019 | 2.096 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.007721 | 2.112 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.008316 | 2.080 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.008316 | 2.080 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.007721 | 2.112 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.007152 | 2.146 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.007721 | 2.112 |
| R-HSA-186763 | Downstream signal transduction | 0.008316 | 2.080 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.006981 | 2.156 |
| R-HSA-186797 | Signaling by PDGF | 0.007938 | 2.100 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.009584 | 2.018 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.009584 | 2.018 |
| R-HSA-74749 | Signal attenuation | 0.009344 | 2.029 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.009584 | 2.018 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.009584 | 2.018 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.010258 | 1.989 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.010959 | 1.960 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.010258 | 1.989 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.010486 | 1.979 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.010959 | 1.960 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.010993 | 1.959 |
| R-HSA-428540 | Activation of RAC1 | 0.012262 | 1.911 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.012312 | 1.910 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.012442 | 1.905 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.011687 | 1.932 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.011687 | 1.932 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.013225 | 1.879 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.013511 | 1.869 |
| R-HSA-8851805 | MET activates RAS signaling | 0.013852 | 1.858 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.015738 | 1.803 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.015738 | 1.803 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.015738 | 1.803 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.014035 | 1.853 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.014873 | 1.828 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.016632 | 1.779 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.019118 | 1.719 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.018333 | 1.737 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.019118 | 1.719 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.018502 | 1.733 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.019479 | 1.710 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.019479 | 1.710 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.020346 | 1.692 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.023022 | 1.638 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.023022 | 1.638 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.021518 | 1.667 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.022580 | 1.646 |
| R-HSA-9634597 | GPER1 signaling | 0.024787 | 1.606 |
| R-HSA-422475 | Axon guidance | 0.024212 | 1.616 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.024614 | 1.609 |
| R-HSA-162582 | Signal Transduction | 0.022202 | 1.654 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.021518 | 1.667 |
| R-HSA-8939211 | ESR-mediated signaling | 0.025036 | 1.601 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.025087 | 1.601 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.025087 | 1.601 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.027224 | 1.565 |
| R-HSA-449147 | Signaling by Interleukins | 0.028063 | 1.552 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.029432 | 1.531 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.031709 | 1.499 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.031709 | 1.499 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.031709 | 1.499 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.031709 | 1.499 |
| R-HSA-167044 | Signalling to RAS | 0.034053 | 1.468 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.037500 | 1.426 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.037610 | 1.425 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.034053 | 1.468 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.034053 | 1.468 |
| R-HSA-9675108 | Nervous system development | 0.036645 | 1.436 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.034736 | 1.459 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.038924 | 1.410 |
| R-HSA-191859 | snRNP Assembly | 0.038924 | 1.410 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.038936 | 1.410 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.041516 | 1.382 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.041852 | 1.378 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.043257 | 1.364 |
| R-HSA-5658034 | HHAT G278V doesn't palmitoylate Hh-Np | 0.043257 | 1.364 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.043268 | 1.364 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.043356 | 1.363 |
| R-HSA-211000 | Gene Silencing by RNA | 0.044012 | 1.356 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.044067 | 1.356 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.044067 | 1.356 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.053778 | 1.269 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.053778 | 1.269 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.046721 | 1.330 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.049630 | 1.304 |
| R-HSA-9839394 | TGFBR3 expression | 0.046721 | 1.330 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.046446 | 1.333 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.053778 | 1.269 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.049433 | 1.306 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.048790 | 1.312 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.049433 | 1.306 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.057895 | 1.237 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.057895 | 1.237 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.057895 | 1.237 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.059848 | 1.223 |
| R-HSA-2424491 | DAP12 signaling | 0.060820 | 1.216 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.060820 | 1.216 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.061638 | 1.210 |
| R-HSA-68875 | Mitotic Prophase | 0.062524 | 1.204 |
| R-HSA-182971 | EGFR downregulation | 0.063794 | 1.195 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 0.064183 | 1.193 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.064183 | 1.193 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.064183 | 1.193 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.064183 | 1.193 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.082605 | 1.083 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.074475 | 1.128 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.082605 | 1.083 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.073001 | 1.137 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.069886 | 1.156 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.076160 | 1.118 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.076160 | 1.118 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.086259 | 1.064 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.079362 | 1.100 |
| R-HSA-74160 | Gene expression (Transcription) | 0.073199 | 1.135 |
| R-HSA-2559583 | Cellular Senescence | 0.071253 | 1.147 |
| R-HSA-6806834 | Signaling by MET | 0.074851 | 1.126 |
| R-HSA-354192 | Integrin signaling | 0.069886 | 1.156 |
| R-HSA-187687 | Signalling to ERKs | 0.079362 | 1.100 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.085888 | 1.066 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.074851 | 1.126 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.065293 | 1.185 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.087878 | 1.056 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.089210 | 1.050 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.094721 | 1.024 |
| R-HSA-9645135 | STAT5 Activation | 0.094721 | 1.024 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.104679 | 0.980 |
| R-HSA-112412 | SOS-mediated signalling | 0.104679 | 0.980 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.114527 | 0.941 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.143432 | 0.843 |
| R-HSA-4839744 | Signaling by APC mutants | 0.143432 | 0.843 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.143432 | 0.843 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.143432 | 0.843 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.143432 | 0.843 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.152856 | 0.816 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.152856 | 0.816 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.162178 | 0.790 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.162178 | 0.790 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.162178 | 0.790 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.162178 | 0.790 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.171397 | 0.766 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.189535 | 0.722 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.189535 | 0.722 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.189535 | 0.722 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.198455 | 0.702 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.207278 | 0.683 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.207278 | 0.683 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.224634 | 0.649 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.241612 | 0.617 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.241612 | 0.617 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.241612 | 0.617 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.249963 | 0.602 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.258221 | 0.588 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.123393 | 0.909 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.202671 | 0.693 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.202671 | 0.693 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.202671 | 0.693 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.162178 | 0.790 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.258221 | 0.588 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.266389 | 0.574 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.162178 | 0.790 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.116210 | 0.935 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.241612 | 0.617 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.124268 | 0.906 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.180516 | 0.743 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.172240 | 0.764 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.143432 | 0.843 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.180516 | 0.743 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.189535 | 0.722 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.266389 | 0.574 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.154344 | 0.812 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.201536 | 0.696 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.229777 | 0.639 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.094721 | 1.024 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.114527 | 0.941 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.152856 | 0.816 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.152856 | 0.816 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.171397 | 0.766 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.198455 | 0.702 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.224634 | 0.649 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.266389 | 0.574 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.100105 | 1.000 |
| R-HSA-3928664 | Ephrin signaling | 0.224634 | 0.649 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.229777 | 0.639 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.229777 | 0.639 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.104609 | 0.980 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.104679 | 0.980 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.124268 | 0.906 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.171397 | 0.766 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.120746 | 0.918 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.124268 | 0.906 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.231818 | 0.635 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.161524 | 0.792 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.124268 | 0.906 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.133903 | 0.873 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 0.152856 | 0.816 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.152856 | 0.816 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.162178 | 0.790 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.180516 | 0.743 |
| R-HSA-2172127 | DAP12 interactions | 0.113452 | 0.945 |
| R-HSA-112399 | IRS-mediated signalling | 0.162060 | 0.790 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.233170 | 0.632 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.162178 | 0.790 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.189535 | 0.722 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.189535 | 0.722 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.207278 | 0.683 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.126395 | 0.898 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.197534 | 0.704 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.203710 | 0.691 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.124268 | 0.906 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.198455 | 0.702 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.233170 | 0.632 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.177690 | 0.750 |
| R-HSA-1640170 | Cell Cycle | 0.111129 | 0.954 |
| R-HSA-9607240 | FLT3 Signaling | 0.099397 | 1.003 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.233170 | 0.632 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.258221 | 0.588 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.266389 | 0.574 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.120661 | 0.918 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.192215 | 0.716 |
| R-HSA-69275 | G2/M Transition | 0.192832 | 0.715 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.171397 | 0.766 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.249963 | 0.602 |
| R-HSA-3214847 | HATs acetylate histones | 0.123393 | 0.909 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.197308 | 0.705 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.090952 | 1.041 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.181634 | 0.741 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.198455 | 0.702 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.207278 | 0.683 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.216004 | 0.666 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.266389 | 0.574 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.102749 | 0.988 |
| R-HSA-418555 | G alpha (s) signalling events | 0.160386 | 0.795 |
| R-HSA-212436 | Generic Transcription Pathway | 0.212090 | 0.673 |
| R-HSA-190236 | Signaling by FGFR | 0.120981 | 0.917 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.207278 | 0.683 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.258221 | 0.588 |
| R-HSA-2586552 | Signaling by Leptin | 0.133903 | 0.873 |
| R-HSA-186712 | Regulation of beta-cell development | 0.169844 | 0.770 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.117042 | 0.932 |
| R-HSA-9675135 | Diseases of DNA repair | 0.120661 | 0.918 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.133903 | 0.873 |
| R-HSA-1170546 | Prolactin receptor signaling | 0.180516 | 0.743 |
| R-HSA-8854214 | TBC/RABGAPs | 0.109891 | 0.959 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.158193 | 0.801 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.180516 | 0.743 |
| R-HSA-9834899 | Specification of the neural plate border | 0.233170 | 0.632 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.270495 | 0.568 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.118587 | 0.926 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.158878 | 0.799 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.186181 | 0.730 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.180516 | 0.743 |
| R-HSA-162587 | HIV Life Cycle | 0.130222 | 0.885 |
| R-HSA-168255 | Influenza Infection | 0.177434 | 0.751 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.133928 | 0.873 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.143432 | 0.843 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.221675 | 0.654 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.213596 | 0.670 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.168833 | 0.773 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.197043 | 0.705 |
| R-HSA-166520 | Signaling by NTRKs | 0.113391 | 0.945 |
| R-HSA-70171 | Glycolysis | 0.125823 | 0.900 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.177672 | 0.750 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.266389 | 0.574 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.229777 | 0.639 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.266389 | 0.574 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.162060 | 0.790 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.130734 | 0.884 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.099321 | 1.003 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.224634 | 0.649 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.266389 | 0.574 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.091887 | 1.037 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.114262 | 0.942 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.213596 | 0.670 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.128270 | 0.892 |
| R-HSA-70326 | Glucose metabolism | 0.177672 | 0.750 |
| R-HSA-201556 | Signaling by ALK | 0.092570 | 1.034 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.260678 | 0.584 |
| R-HSA-3371556 | Cellular response to heat stress | 0.188677 | 0.724 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.233836 | 0.631 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.257661 | 0.589 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.272277 | 0.565 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.274468 | 0.562 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.274468 | 0.562 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.274468 | 0.562 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.274572 | 0.561 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.274572 | 0.561 |
| R-HSA-195721 | Signaling by WNT | 0.276487 | 0.558 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.282459 | 0.549 |
| R-HSA-429947 | Deadenylation of mRNA | 0.282459 | 0.549 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.282723 | 0.549 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.282723 | 0.549 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.284493 | 0.546 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.290361 | 0.537 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.290361 | 0.537 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.290361 | 0.537 |
| R-HSA-162906 | HIV Infection | 0.292131 | 0.534 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.296474 | 0.528 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.298178 | 0.526 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.298178 | 0.526 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.299000 | 0.524 |
| R-HSA-9610379 | HCMV Late Events | 0.305480 | 0.515 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.305908 | 0.514 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.305908 | 0.514 |
| R-HSA-201451 | Signaling by BMP | 0.305908 | 0.514 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.307118 | 0.513 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.313554 | 0.504 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.313554 | 0.504 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.313554 | 0.504 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.314498 | 0.502 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.321116 | 0.493 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.321116 | 0.493 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.321116 | 0.493 |
| R-HSA-157118 | Signaling by NOTCH | 0.324329 | 0.489 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.328596 | 0.483 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.328596 | 0.483 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.328596 | 0.483 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.328596 | 0.483 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.328596 | 0.483 |
| R-HSA-5619102 | SLC transporter disorders | 0.335559 | 0.474 |
| R-HSA-1266738 | Developmental Biology | 0.335931 | 0.474 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.335993 | 0.474 |
| R-HSA-1538133 | G0 and Early G1 | 0.343309 | 0.464 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.343309 | 0.464 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.343309 | 0.464 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.343309 | 0.464 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.343309 | 0.464 |
| R-HSA-72306 | tRNA processing | 0.347585 | 0.459 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.350546 | 0.455 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.350546 | 0.455 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.350546 | 0.455 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.350546 | 0.455 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.350546 | 0.455 |
| R-HSA-9733709 | Cardiogenesis | 0.350546 | 0.455 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.353591 | 0.451 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.356592 | 0.448 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.356592 | 0.448 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.357703 | 0.446 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.364781 | 0.438 |
| R-HSA-5673000 | RAF activation | 0.364781 | 0.438 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.367236 | 0.435 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.367236 | 0.435 |
| R-HSA-9833110 | RSV-host interactions | 0.367236 | 0.435 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.369248 | 0.433 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.371782 | 0.430 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.378706 | 0.422 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.378706 | 0.422 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.378706 | 0.422 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.379038 | 0.421 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.379038 | 0.421 |
| R-HSA-388396 | GPCR downstream signalling | 0.383913 | 0.416 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.385554 | 0.414 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.385554 | 0.414 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.386855 | 0.412 |
| R-HSA-8875878 | MET promotes cell motility | 0.392327 | 0.406 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.398500 | 0.400 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.399026 | 0.399 |
| R-HSA-69541 | Stabilization of p53 | 0.399026 | 0.399 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.399026 | 0.399 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.405652 | 0.392 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.405652 | 0.392 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.406207 | 0.391 |
| R-HSA-5617833 | Cilium Assembly | 0.407213 | 0.390 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.412205 | 0.385 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.412205 | 0.385 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.413866 | 0.383 |
| R-HSA-68877 | Mitotic Prometaphase | 0.416038 | 0.381 |
| R-HSA-167161 | HIV Transcription Initiation | 0.418686 | 0.378 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.418686 | 0.378 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.418686 | 0.378 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.418686 | 0.378 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.418686 | 0.378 |
| R-HSA-9609690 | HCMV Early Events | 0.424822 | 0.372 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.424822 | 0.372 |
| R-HSA-165159 | MTOR signalling | 0.425096 | 0.372 |
| R-HSA-5693538 | Homology Directed Repair | 0.429036 | 0.368 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.429036 | 0.368 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.431435 | 0.365 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.431435 | 0.365 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.432797 | 0.364 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.436463 | 0.360 |
| R-HSA-69236 | G1 Phase | 0.437706 | 0.359 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.437706 | 0.359 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.437706 | 0.359 |
| R-HSA-373752 | Netrin-1 signaling | 0.437706 | 0.359 |
| R-HSA-9907900 | Proteasome assembly | 0.437706 | 0.359 |
| R-HSA-73886 | Chromosome Maintenance | 0.440279 | 0.356 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.443907 | 0.353 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.443907 | 0.353 |
| R-HSA-774815 | Nucleosome assembly | 0.443907 | 0.353 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.443907 | 0.353 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.450040 | 0.347 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.450040 | 0.347 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.450040 | 0.347 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.450040 | 0.347 |
| R-HSA-75153 | Apoptotic execution phase | 0.450040 | 0.347 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.456107 | 0.341 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.456107 | 0.341 |
| R-HSA-69206 | G1/S Transition | 0.458744 | 0.338 |
| R-HSA-68886 | M Phase | 0.460373 | 0.337 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.460498 | 0.337 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.462106 | 0.335 |
| R-HSA-69481 | G2/M Checkpoints | 0.466032 | 0.332 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.468040 | 0.330 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.468040 | 0.330 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.468040 | 0.330 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.469654 | 0.328 |
| R-HSA-109704 | PI3K Cascade | 0.473909 | 0.324 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.473909 | 0.324 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.476472 | 0.322 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.479713 | 0.319 |
| R-HSA-2262752 | Cellular responses to stress | 0.480323 | 0.318 |
| R-HSA-72187 | mRNA 3'-end processing | 0.485453 | 0.314 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.485453 | 0.314 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.485453 | 0.314 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.485453 | 0.314 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.485453 | 0.314 |
| R-HSA-9909396 | Circadian clock | 0.487545 | 0.312 |
| R-HSA-418990 | Adherens junctions interactions | 0.490449 | 0.309 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.491131 | 0.309 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.502300 | 0.299 |
| R-HSA-372790 | Signaling by GPCR | 0.507237 | 0.295 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.507793 | 0.294 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.507793 | 0.294 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.508513 | 0.294 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.511953 | 0.291 |
| R-HSA-6807070 | PTEN Regulation | 0.515378 | 0.288 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.515378 | 0.288 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.517845 | 0.286 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.518598 | 0.285 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.518787 | 0.285 |
| R-HSA-9664407 | Parasite infection | 0.518787 | 0.285 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.518787 | 0.285 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.522180 | 0.282 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.523912 | 0.281 |
| R-HSA-180786 | Extension of Telomeres | 0.523912 | 0.281 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.523912 | 0.281 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.529167 | 0.276 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.529167 | 0.276 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.529167 | 0.276 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.529167 | 0.276 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.529167 | 0.276 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.529167 | 0.276 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.529167 | 0.276 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.529167 | 0.276 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.534365 | 0.272 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.534365 | 0.272 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.534365 | 0.272 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.539506 | 0.268 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.539506 | 0.268 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.539506 | 0.268 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.541818 | 0.266 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.542200 | 0.266 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.544590 | 0.264 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.544590 | 0.264 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.544590 | 0.264 |
| R-HSA-69242 | S Phase | 0.548745 | 0.261 |
| R-HSA-9758941 | Gastrulation | 0.551992 | 0.258 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.554592 | 0.256 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.555223 | 0.256 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.559511 | 0.252 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.564376 | 0.248 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.564818 | 0.248 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.567640 | 0.246 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.569047 | 0.245 |
| R-HSA-167172 | Transcription of the HIV genome | 0.569187 | 0.245 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.569187 | 0.245 |
| R-HSA-9609646 | HCMV Infection | 0.575212 | 0.240 |
| R-HSA-421270 | Cell-cell junction organization | 0.577718 | 0.238 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.578651 | 0.238 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.578651 | 0.238 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.578651 | 0.238 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.580480 | 0.236 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.583306 | 0.234 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.583306 | 0.234 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.583306 | 0.234 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.583306 | 0.234 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.590109 | 0.229 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.592462 | 0.227 |
| R-HSA-4086398 | Ca2+ pathway | 0.592462 | 0.227 |
| R-HSA-109581 | Apoptosis | 0.592710 | 0.227 |
| R-HSA-380287 | Centrosome maturation | 0.601418 | 0.221 |
| R-HSA-8852135 | Protein ubiquitination | 0.601418 | 0.221 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.605822 | 0.218 |
| R-HSA-8953854 | Metabolism of RNA | 0.608464 | 0.216 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.610178 | 0.215 |
| R-HSA-9679506 | SARS-CoV Infections | 0.615071 | 0.211 |
| R-HSA-9659379 | Sensory processing of sound | 0.618747 | 0.208 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.622961 | 0.206 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.622961 | 0.206 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.627128 | 0.203 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.630623 | 0.200 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.639358 | 0.194 |
| R-HSA-446728 | Cell junction organization | 0.641810 | 0.193 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.642829 | 0.192 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.643345 | 0.192 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.647289 | 0.189 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.647289 | 0.189 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.647289 | 0.189 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.651189 | 0.186 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.655046 | 0.184 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.655046 | 0.184 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.658861 | 0.181 |
| R-HSA-156902 | Peptide chain elongation | 0.658861 | 0.181 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.666365 | 0.176 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.670055 | 0.174 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.670055 | 0.174 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.673705 | 0.172 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.677315 | 0.169 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.677315 | 0.169 |
| R-HSA-391251 | Protein folding | 0.677315 | 0.169 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.680885 | 0.167 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.683528 | 0.165 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.684415 | 0.165 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.687907 | 0.162 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.691360 | 0.160 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.691360 | 0.160 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.691360 | 0.160 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.694776 | 0.158 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.694776 | 0.158 |
| R-HSA-157579 | Telomere Maintenance | 0.698153 | 0.156 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.698153 | 0.156 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.701494 | 0.154 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.701494 | 0.154 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.701494 | 0.154 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.708065 | 0.150 |
| R-HSA-72172 | mRNA Splicing | 0.709905 | 0.149 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.711297 | 0.148 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.711297 | 0.148 |
| R-HSA-5357801 | Programmed Cell Death | 0.712210 | 0.147 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.714493 | 0.146 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.714493 | 0.146 |
| R-HSA-1483255 | PI Metabolism | 0.714493 | 0.146 |
| R-HSA-192823 | Viral mRNA Translation | 0.717653 | 0.144 |
| R-HSA-1500931 | Cell-Cell communication | 0.719980 | 0.143 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.720779 | 0.142 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.726928 | 0.139 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.727390 | 0.138 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.727920 | 0.138 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.732943 | 0.135 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.735900 | 0.133 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.735900 | 0.133 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.735900 | 0.133 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.738825 | 0.131 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.741718 | 0.130 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.741718 | 0.130 |
| R-HSA-168256 | Immune System | 0.743959 | 0.128 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.747408 | 0.126 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.747408 | 0.126 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.750207 | 0.125 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.758418 | 0.120 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.761095 | 0.119 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.763742 | 0.117 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.763742 | 0.117 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.771511 | 0.113 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.771511 | 0.113 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.776548 | 0.110 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.776612 | 0.110 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.779025 | 0.108 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.779025 | 0.108 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.781475 | 0.107 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.781475 | 0.107 |
| R-HSA-1643685 | Disease | 0.784262 | 0.106 |
| R-HSA-194138 | Signaling by VEGF | 0.788664 | 0.103 |
| R-HSA-109582 | Hemostasis | 0.790782 | 0.102 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.800126 | 0.097 |
| R-HSA-9843745 | Adipogenesis | 0.804536 | 0.094 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.806704 | 0.093 |
| R-HSA-5688426 | Deubiquitination | 0.809266 | 0.092 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.817193 | 0.088 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.821228 | 0.086 |
| R-HSA-9824446 | Viral Infection Pathways | 0.822540 | 0.085 |
| R-HSA-913531 | Interferon Signaling | 0.826109 | 0.083 |
| R-HSA-1632852 | Macroautophagy | 0.827116 | 0.082 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.832810 | 0.079 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.837790 | 0.077 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.841889 | 0.075 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.847100 | 0.072 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.847293 | 0.072 |
| R-HSA-9658195 | Leishmania infection | 0.847293 | 0.072 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.848609 | 0.071 |
| R-HSA-1989781 | PPARA activates gene expression | 0.853783 | 0.069 |
| R-HSA-9612973 | Autophagy | 0.855407 | 0.068 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.857014 | 0.067 |
| R-HSA-9711097 | Cellular response to starvation | 0.858603 | 0.066 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.867776 | 0.062 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.867776 | 0.062 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.877731 | 0.057 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.879091 | 0.056 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.881766 | 0.055 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.894444 | 0.048 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.899202 | 0.046 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.900039 | 0.046 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.903342 | 0.044 |
| R-HSA-112316 | Neuronal System | 0.909000 | 0.041 |
| R-HSA-73894 | DNA Repair | 0.924433 | 0.034 |
| R-HSA-68882 | Mitotic Anaphase | 0.927778 | 0.033 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.928584 | 0.032 |
| R-HSA-8951664 | Neddylation | 0.931718 | 0.031 |
| R-HSA-168249 | Innate Immune System | 0.935971 | 0.029 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.939397 | 0.027 |
| R-HSA-72312 | rRNA processing | 0.939650 | 0.027 |
| R-HSA-199991 | Membrane Trafficking | 0.940425 | 0.027 |
| R-HSA-1280218 | Adaptive Immune System | 0.954069 | 0.020 |
| R-HSA-416476 | G alpha (q) signalling events | 0.957883 | 0.019 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.959737 | 0.018 |
| R-HSA-597592 | Post-translational protein modification | 0.965277 | 0.015 |
| R-HSA-6798695 | Neutrophil degranulation | 0.969814 | 0.013 |
| R-HSA-1483257 | Phospholipid metabolism | 0.970296 | 0.013 |
| R-HSA-5663205 | Infectious disease | 0.971062 | 0.013 |
| R-HSA-1474244 | Extracellular matrix organization | 0.980215 | 0.009 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.983190 | 0.007 |
| R-HSA-72766 | Translation | 0.993559 | 0.003 |
| R-HSA-392499 | Metabolism of proteins | 0.998737 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998966 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999259 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.880 | 0.828 | 1 | 0.881 |
KIS |
0.870 | 0.771 | 1 | 0.839 |
CDK18 |
0.869 | 0.837 | 1 | 0.888 |
CDK19 |
0.869 | 0.821 | 1 | 0.882 |
P38G |
0.866 | 0.859 | 1 | 0.910 |
CDK17 |
0.864 | 0.843 | 1 | 0.902 |
CDK8 |
0.863 | 0.815 | 1 | 0.856 |
CDK7 |
0.862 | 0.816 | 1 | 0.859 |
DYRK2 |
0.862 | 0.798 | 1 | 0.815 |
JNK2 |
0.862 | 0.863 | 1 | 0.890 |
P38D |
0.859 | 0.844 | 1 | 0.929 |
CDK1 |
0.859 | 0.807 | 1 | 0.865 |
CDK3 |
0.858 | 0.743 | 1 | 0.898 |
ERK1 |
0.857 | 0.822 | 1 | 0.879 |
HIPK1 |
0.857 | 0.760 | 1 | 0.801 |
DYRK4 |
0.857 | 0.793 | 1 | 0.888 |
HIPK4 |
0.856 | 0.603 | 1 | 0.636 |
CDK16 |
0.856 | 0.802 | 1 | 0.894 |
CDK10 |
0.854 | 0.779 | 1 | 0.871 |
CDK5 |
0.854 | 0.786 | 1 | 0.835 |
P38B |
0.854 | 0.827 | 1 | 0.860 |
CDK13 |
0.853 | 0.799 | 1 | 0.876 |
CDK12 |
0.853 | 0.804 | 1 | 0.892 |
JNK3 |
0.852 | 0.847 | 1 | 0.871 |
CLK3 |
0.852 | 0.559 | 1 | 0.589 |
CDK14 |
0.850 | 0.811 | 1 | 0.861 |
DYRK1B |
0.848 | 0.764 | 1 | 0.846 |
CDK9 |
0.847 | 0.791 | 1 | 0.874 |
HIPK3 |
0.845 | 0.737 | 1 | 0.780 |
SRPK1 |
0.845 | 0.442 | -3 | 0.866 |
DYRK1A |
0.844 | 0.687 | 1 | 0.786 |
P38A |
0.844 | 0.796 | 1 | 0.812 |
NLK |
0.840 | 0.743 | 1 | 0.639 |
ERK2 |
0.838 | 0.793 | 1 | 0.839 |
DYRK3 |
0.835 | 0.612 | 1 | 0.769 |
CDK4 |
0.835 | 0.787 | 1 | 0.899 |
CLK2 |
0.835 | 0.488 | -3 | 0.858 |
CDK6 |
0.834 | 0.763 | 1 | 0.879 |
MAK |
0.833 | 0.595 | -2 | 0.833 |
CLK1 |
0.832 | 0.486 | -3 | 0.834 |
JNK1 |
0.831 | 0.754 | 1 | 0.882 |
SRPK2 |
0.831 | 0.369 | -3 | 0.808 |
ICK |
0.828 | 0.473 | -3 | 0.907 |
CLK4 |
0.828 | 0.452 | -3 | 0.859 |
ERK5 |
0.827 | 0.415 | 1 | 0.547 |
CDKL5 |
0.826 | 0.288 | -3 | 0.884 |
CDK2 |
0.823 | 0.599 | 1 | 0.765 |
CDKL1 |
0.822 | 0.272 | -3 | 0.892 |
MOK |
0.821 | 0.555 | 1 | 0.698 |
MTOR |
0.821 | 0.250 | 1 | 0.452 |
SRPK3 |
0.819 | 0.325 | -3 | 0.845 |
COT |
0.815 | -0.027 | 2 | 0.847 |
PIM3 |
0.813 | 0.097 | -3 | 0.910 |
PRKD1 |
0.810 | 0.110 | -3 | 0.883 |
MOS |
0.809 | 0.058 | 1 | 0.312 |
NDR2 |
0.809 | 0.079 | -3 | 0.892 |
PRP4 |
0.806 | 0.454 | -3 | 0.779 |
ERK7 |
0.806 | 0.314 | 2 | 0.620 |
PRKD2 |
0.806 | 0.104 | -3 | 0.852 |
RSK2 |
0.805 | 0.108 | -3 | 0.868 |
PIM1 |
0.804 | 0.132 | -3 | 0.878 |
CDC7 |
0.804 | -0.058 | 1 | 0.263 |
P90RSK |
0.804 | 0.120 | -3 | 0.871 |
PKN3 |
0.804 | 0.055 | -3 | 0.884 |
ATR |
0.803 | 0.006 | 1 | 0.333 |
PRPK |
0.803 | -0.039 | -1 | 0.826 |
TBK1 |
0.803 | -0.112 | 1 | 0.261 |
CAMK1B |
0.802 | 0.052 | -3 | 0.907 |
NUAK2 |
0.801 | 0.082 | -3 | 0.891 |
RSK3 |
0.801 | 0.083 | -3 | 0.862 |
NDR1 |
0.801 | 0.031 | -3 | 0.892 |
CHAK2 |
0.800 | 0.009 | -1 | 0.798 |
PKCD |
0.800 | 0.052 | 2 | 0.796 |
IKKB |
0.800 | -0.111 | -2 | 0.739 |
MST4 |
0.799 | -0.012 | 2 | 0.844 |
IKKE |
0.799 | -0.126 | 1 | 0.262 |
MAPKAPK3 |
0.798 | 0.051 | -3 | 0.850 |
PKN2 |
0.798 | 0.013 | -3 | 0.883 |
AURC |
0.797 | 0.067 | -2 | 0.668 |
RAF1 |
0.797 | -0.154 | 1 | 0.284 |
NIK |
0.797 | 0.023 | -3 | 0.902 |
GCN2 |
0.797 | -0.175 | 2 | 0.800 |
SKMLCK |
0.797 | 0.025 | -2 | 0.876 |
MAPKAPK2 |
0.796 | 0.073 | -3 | 0.835 |
WNK1 |
0.796 | -0.044 | -2 | 0.895 |
GRK1 |
0.795 | 0.036 | -2 | 0.806 |
CAMLCK |
0.794 | 0.049 | -2 | 0.850 |
AMPKA1 |
0.794 | 0.007 | -3 | 0.892 |
P70S6KB |
0.794 | 0.067 | -3 | 0.873 |
AMPKA2 |
0.794 | 0.042 | -3 | 0.876 |
RSK4 |
0.794 | 0.113 | -3 | 0.846 |
MLK2 |
0.793 | -0.032 | 2 | 0.843 |
PDHK4 |
0.793 | -0.169 | 1 | 0.344 |
PKCB |
0.793 | 0.043 | 2 | 0.769 |
PHKG1 |
0.793 | 0.022 | -3 | 0.882 |
BMPR2 |
0.793 | -0.168 | -2 | 0.848 |
PKACG |
0.793 | 0.030 | -2 | 0.739 |
PRKD3 |
0.792 | 0.081 | -3 | 0.834 |
PKCA |
0.792 | 0.051 | 2 | 0.758 |
AKT2 |
0.792 | 0.125 | -3 | 0.801 |
MLK1 |
0.791 | -0.106 | 2 | 0.826 |
DSTYK |
0.791 | -0.154 | 2 | 0.881 |
ULK2 |
0.791 | -0.194 | 2 | 0.777 |
DAPK2 |
0.791 | 0.032 | -3 | 0.902 |
PKACB |
0.790 | 0.090 | -2 | 0.675 |
MLK3 |
0.790 | -0.016 | 2 | 0.772 |
LATS2 |
0.790 | 0.012 | -5 | 0.728 |
NEK6 |
0.790 | -0.099 | -2 | 0.804 |
MARK4 |
0.789 | -0.035 | 4 | 0.794 |
TGFBR2 |
0.789 | -0.088 | -2 | 0.731 |
CAMK2D |
0.789 | -0.025 | -3 | 0.877 |
MPSK1 |
0.788 | 0.123 | 1 | 0.339 |
IKKA |
0.788 | -0.063 | -2 | 0.730 |
PDHK1 |
0.788 | -0.185 | 1 | 0.330 |
PKCZ |
0.788 | 0.019 | 2 | 0.806 |
PKCG |
0.788 | 0.021 | 2 | 0.760 |
IRE1 |
0.787 | -0.070 | 1 | 0.277 |
LATS1 |
0.787 | 0.086 | -3 | 0.896 |
SGK3 |
0.786 | 0.074 | -3 | 0.840 |
RIPK3 |
0.786 | -0.139 | 3 | 0.712 |
PIM2 |
0.786 | 0.118 | -3 | 0.839 |
PAK1 |
0.786 | 0.001 | -2 | 0.808 |
GRK7 |
0.786 | 0.038 | 1 | 0.279 |
MSK2 |
0.786 | 0.047 | -3 | 0.850 |
MNK1 |
0.785 | 0.030 | -2 | 0.794 |
TSSK1 |
0.785 | -0.005 | -3 | 0.903 |
GSK3A |
0.785 | 0.219 | 4 | 0.473 |
MNK2 |
0.785 | -0.006 | -2 | 0.792 |
CAMK2G |
0.785 | -0.123 | 2 | 0.755 |
PAK3 |
0.785 | -0.023 | -2 | 0.801 |
DNAPK |
0.784 | -0.024 | 1 | 0.340 |
PAK6 |
0.784 | 0.032 | -2 | 0.720 |
BCKDK |
0.784 | -0.149 | -1 | 0.745 |
PKG2 |
0.784 | 0.046 | -2 | 0.675 |
NUAK1 |
0.784 | 0.025 | -3 | 0.856 |
PRKX |
0.784 | 0.103 | -3 | 0.778 |
GRK5 |
0.783 | -0.135 | -3 | 0.856 |
QSK |
0.783 | 0.019 | 4 | 0.774 |
HUNK |
0.782 | -0.151 | 2 | 0.783 |
DLK |
0.782 | -0.147 | 1 | 0.281 |
MELK |
0.782 | -0.012 | -3 | 0.861 |
MASTL |
0.782 | -0.132 | -2 | 0.801 |
NEK7 |
0.782 | -0.210 | -3 | 0.815 |
NEK9 |
0.782 | -0.165 | 2 | 0.841 |
NIM1 |
0.782 | -0.063 | 3 | 0.777 |
PKCH |
0.781 | 0.001 | 2 | 0.747 |
MSK1 |
0.781 | 0.059 | -3 | 0.848 |
WNK3 |
0.781 | -0.203 | 1 | 0.289 |
CAMK2A |
0.781 | 0.034 | 2 | 0.753 |
AURB |
0.780 | 0.022 | -2 | 0.662 |
YSK4 |
0.780 | -0.104 | 1 | 0.267 |
SIK |
0.780 | 0.023 | -3 | 0.838 |
AKT1 |
0.780 | 0.090 | -3 | 0.809 |
TSSK2 |
0.780 | -0.059 | -5 | 0.823 |
IRE2 |
0.780 | -0.065 | 2 | 0.744 |
CAMK4 |
0.779 | -0.062 | -3 | 0.864 |
ATM |
0.779 | -0.074 | 1 | 0.298 |
CHAK1 |
0.779 | -0.096 | 2 | 0.814 |
RIPK1 |
0.779 | -0.175 | 1 | 0.270 |
PKR |
0.779 | -0.066 | 1 | 0.298 |
BMPR1B |
0.778 | -0.051 | 1 | 0.216 |
ULK1 |
0.778 | -0.202 | -3 | 0.788 |
TTBK2 |
0.778 | -0.159 | 2 | 0.697 |
VRK2 |
0.778 | 0.047 | 1 | 0.376 |
CAMK2B |
0.778 | -0.020 | 2 | 0.729 |
BRSK1 |
0.778 | 0.005 | -3 | 0.862 |
MLK4 |
0.777 | -0.077 | 2 | 0.751 |
SMG1 |
0.777 | -0.063 | 1 | 0.322 |
PINK1 |
0.777 | 0.135 | 1 | 0.475 |
MST3 |
0.776 | -0.002 | 2 | 0.853 |
QIK |
0.776 | -0.069 | -3 | 0.858 |
PKCT |
0.776 | 0.011 | 2 | 0.752 |
BRSK2 |
0.776 | -0.032 | -3 | 0.859 |
DCAMKL1 |
0.775 | 0.024 | -3 | 0.857 |
ANKRD3 |
0.775 | -0.188 | 1 | 0.300 |
GRK6 |
0.775 | -0.141 | 1 | 0.254 |
MYLK4 |
0.774 | 0.015 | -2 | 0.783 |
PAK2 |
0.774 | -0.040 | -2 | 0.788 |
NEK2 |
0.773 | -0.129 | 2 | 0.836 |
MAPKAPK5 |
0.773 | -0.006 | -3 | 0.817 |
PKACA |
0.773 | 0.071 | -2 | 0.626 |
AKT3 |
0.773 | 0.113 | -3 | 0.759 |
CAMK1G |
0.772 | 0.011 | -3 | 0.849 |
ALK4 |
0.772 | -0.088 | -2 | 0.786 |
MEK1 |
0.772 | -0.129 | 2 | 0.831 |
TAO3 |
0.771 | -0.009 | 1 | 0.306 |
PHKG2 |
0.771 | -0.025 | -3 | 0.849 |
PKCE |
0.771 | 0.061 | 2 | 0.751 |
TGFBR1 |
0.771 | -0.082 | -2 | 0.760 |
PKCI |
0.770 | 0.015 | 2 | 0.775 |
GRK4 |
0.769 | -0.169 | -2 | 0.807 |
AURA |
0.769 | 0.000 | -2 | 0.637 |
MARK3 |
0.769 | -0.032 | 4 | 0.724 |
SBK |
0.769 | 0.207 | -3 | 0.708 |
CHK1 |
0.769 | -0.025 | -3 | 0.853 |
SGK1 |
0.768 | 0.127 | -3 | 0.743 |
GSK3B |
0.768 | 0.068 | 4 | 0.468 |
TLK2 |
0.768 | -0.131 | 1 | 0.279 |
MEK5 |
0.768 | -0.121 | 2 | 0.823 |
P70S6K |
0.768 | 0.046 | -3 | 0.807 |
PASK |
0.768 | 0.046 | -3 | 0.906 |
CK1E |
0.768 | 0.008 | -3 | 0.579 |
PKN1 |
0.768 | 0.051 | -3 | 0.812 |
IRAK4 |
0.768 | -0.109 | 1 | 0.267 |
MEKK2 |
0.767 | -0.098 | 2 | 0.813 |
MEKK1 |
0.767 | -0.132 | 1 | 0.292 |
FAM20C |
0.766 | -0.041 | 2 | 0.574 |
PAK5 |
0.766 | 0.002 | -2 | 0.661 |
ZAK |
0.766 | -0.143 | 1 | 0.270 |
WNK4 |
0.765 | -0.114 | -2 | 0.881 |
MARK2 |
0.765 | -0.053 | 4 | 0.691 |
SSTK |
0.764 | -0.030 | 4 | 0.766 |
PDK1 |
0.764 | -0.001 | 1 | 0.316 |
DRAK1 |
0.764 | -0.132 | 1 | 0.220 |
MEKK3 |
0.764 | -0.156 | 1 | 0.279 |
SNRK |
0.764 | -0.131 | 2 | 0.650 |
PERK |
0.763 | -0.157 | -2 | 0.782 |
ACVR2B |
0.763 | -0.122 | -2 | 0.735 |
DCAMKL2 |
0.763 | -0.022 | -3 | 0.865 |
SMMLCK |
0.763 | 0.013 | -3 | 0.881 |
PAK4 |
0.763 | 0.013 | -2 | 0.669 |
MAP3K15 |
0.763 | -0.040 | 1 | 0.288 |
ACVR2A |
0.763 | -0.128 | -2 | 0.718 |
GCK |
0.762 | -0.023 | 1 | 0.287 |
NEK5 |
0.762 | -0.148 | 1 | 0.284 |
GRK2 |
0.762 | -0.086 | -2 | 0.707 |
GAK |
0.762 | -0.009 | 1 | 0.322 |
ALK2 |
0.761 | -0.113 | -2 | 0.770 |
MEKK6 |
0.761 | -0.057 | 1 | 0.291 |
KHS1 |
0.761 | 0.016 | 1 | 0.292 |
BUB1 |
0.761 | 0.054 | -5 | 0.769 |
CK1D |
0.761 | 0.029 | -3 | 0.529 |
PLK1 |
0.760 | -0.201 | -2 | 0.728 |
LKB1 |
0.760 | -0.034 | -3 | 0.813 |
PLK4 |
0.760 | -0.157 | 2 | 0.590 |
CAMK1D |
0.760 | 0.037 | -3 | 0.780 |
TAO2 |
0.760 | -0.046 | 2 | 0.844 |
NEK11 |
0.760 | -0.112 | 1 | 0.300 |
TNIK |
0.760 | -0.013 | 3 | 0.888 |
MRCKB |
0.760 | 0.064 | -3 | 0.824 |
HRI |
0.759 | -0.195 | -2 | 0.795 |
CHK2 |
0.759 | 0.069 | -3 | 0.754 |
ROCK2 |
0.759 | 0.065 | -3 | 0.856 |
HGK |
0.759 | -0.045 | 3 | 0.883 |
HPK1 |
0.759 | -0.031 | 1 | 0.289 |
CK1G1 |
0.758 | -0.035 | -3 | 0.584 |
MARK1 |
0.758 | -0.077 | 4 | 0.742 |
KHS2 |
0.757 | 0.019 | 1 | 0.301 |
BRAF |
0.757 | -0.159 | -4 | 0.819 |
LOK |
0.757 | -0.036 | -2 | 0.752 |
MINK |
0.756 | -0.083 | 1 | 0.274 |
CAMK1A |
0.756 | 0.057 | -3 | 0.774 |
DAPK3 |
0.756 | 0.021 | -3 | 0.877 |
LRRK2 |
0.755 | 0.008 | 2 | 0.839 |
PBK |
0.755 | -0.001 | 1 | 0.302 |
BMPR1A |
0.755 | -0.091 | 1 | 0.204 |
TLK1 |
0.755 | -0.173 | -2 | 0.785 |
NEK8 |
0.754 | -0.150 | 2 | 0.818 |
MRCKA |
0.754 | 0.046 | -3 | 0.835 |
PLK3 |
0.754 | -0.174 | 2 | 0.715 |
HASPIN |
0.753 | 0.025 | -1 | 0.654 |
CK1A2 |
0.753 | -0.005 | -3 | 0.533 |
DMPK1 |
0.753 | 0.095 | -3 | 0.847 |
SLK |
0.752 | -0.038 | -2 | 0.694 |
NEK4 |
0.752 | -0.154 | 1 | 0.275 |
EEF2K |
0.751 | -0.067 | 3 | 0.838 |
MST2 |
0.750 | -0.129 | 1 | 0.273 |
CRIK |
0.750 | 0.095 | -3 | 0.812 |
TAK1 |
0.749 | -0.142 | 1 | 0.277 |
TTBK1 |
0.749 | -0.175 | 2 | 0.599 |
DAPK1 |
0.748 | 0.014 | -3 | 0.867 |
YSK1 |
0.748 | -0.082 | 2 | 0.825 |
CAMKK1 |
0.747 | -0.213 | -2 | 0.754 |
GRK3 |
0.747 | -0.083 | -2 | 0.667 |
NEK1 |
0.746 | -0.147 | 1 | 0.267 |
CAMKK2 |
0.746 | -0.163 | -2 | 0.755 |
VRK1 |
0.746 | -0.143 | 2 | 0.808 |
ROCK1 |
0.746 | 0.047 | -3 | 0.835 |
PKG1 |
0.745 | 0.017 | -2 | 0.591 |
IRAK1 |
0.743 | -0.245 | -1 | 0.711 |
PDHK3_TYR |
0.743 | 0.158 | 4 | 0.846 |
MST1 |
0.743 | -0.136 | 1 | 0.267 |
LIMK2_TYR |
0.742 | 0.176 | -3 | 0.887 |
CK2A2 |
0.739 | -0.085 | 1 | 0.178 |
OSR1 |
0.739 | -0.062 | 2 | 0.818 |
TESK1_TYR |
0.739 | 0.095 | 3 | 0.891 |
BIKE |
0.738 | -0.023 | 1 | 0.301 |
NEK3 |
0.737 | -0.130 | 1 | 0.295 |
AAK1 |
0.736 | 0.025 | 1 | 0.296 |
MYO3B |
0.736 | -0.051 | 2 | 0.842 |
PDHK4_TYR |
0.736 | 0.079 | 2 | 0.847 |
PKMYT1_TYR |
0.736 | 0.146 | 3 | 0.848 |
ASK1 |
0.735 | -0.098 | 1 | 0.284 |
STK33 |
0.735 | -0.154 | 2 | 0.596 |
MAP2K4_TYR |
0.735 | 0.060 | -1 | 0.834 |
TAO1 |
0.734 | -0.073 | 1 | 0.280 |
RIPK2 |
0.733 | -0.231 | 1 | 0.252 |
MEK2 |
0.732 | -0.223 | 2 | 0.806 |
CK2A1 |
0.732 | -0.088 | 1 | 0.167 |
MAP2K6_TYR |
0.732 | 0.040 | -1 | 0.838 |
MAP2K7_TYR |
0.731 | -0.047 | 2 | 0.829 |
MYO3A |
0.730 | -0.082 | 1 | 0.287 |
PLK2 |
0.730 | -0.111 | -3 | 0.771 |
BMPR2_TYR |
0.729 | 0.014 | -1 | 0.834 |
TTK |
0.728 | -0.106 | -2 | 0.756 |
PINK1_TYR |
0.728 | -0.092 | 1 | 0.324 |
RET |
0.728 | -0.092 | 1 | 0.308 |
PDHK1_TYR |
0.727 | -0.034 | -1 | 0.841 |
LIMK1_TYR |
0.727 | 0.019 | 2 | 0.836 |
NEK10_TYR |
0.725 | -0.055 | 1 | 0.288 |
JAK2 |
0.722 | -0.099 | 1 | 0.319 |
TYK2 |
0.722 | -0.163 | 1 | 0.300 |
MST1R |
0.722 | -0.092 | 3 | 0.803 |
YANK3 |
0.722 | -0.058 | 2 | 0.365 |
CSF1R |
0.722 | -0.073 | 3 | 0.786 |
JAK1 |
0.721 | -0.039 | 1 | 0.290 |
ALPHAK3 |
0.720 | -0.100 | -1 | 0.732 |
ROS1 |
0.720 | -0.099 | 3 | 0.777 |
TNNI3K_TYR |
0.719 | -0.014 | 1 | 0.312 |
JAK3 |
0.719 | -0.102 | 1 | 0.294 |
CK1A |
0.718 | -0.025 | -3 | 0.446 |
ABL2 |
0.717 | -0.091 | -1 | 0.741 |
EPHA6 |
0.717 | -0.100 | -1 | 0.801 |
STLK3 |
0.716 | -0.172 | 1 | 0.253 |
TYRO3 |
0.716 | -0.157 | 3 | 0.808 |
TNK1 |
0.715 | -0.047 | 3 | 0.786 |
EPHB4 |
0.715 | -0.124 | -1 | 0.774 |
TXK |
0.714 | -0.073 | 1 | 0.219 |
TNK2 |
0.713 | -0.084 | 3 | 0.748 |
ABL1 |
0.713 | -0.104 | -1 | 0.735 |
FGR |
0.713 | -0.118 | 1 | 0.252 |
LCK |
0.712 | -0.071 | -1 | 0.796 |
YES1 |
0.712 | -0.099 | -1 | 0.806 |
KDR |
0.711 | -0.080 | 3 | 0.734 |
DDR1 |
0.711 | -0.149 | 4 | 0.751 |
FGFR2 |
0.710 | -0.072 | 3 | 0.769 |
FGFR1 |
0.709 | -0.064 | 3 | 0.750 |
KIT |
0.708 | -0.130 | 3 | 0.781 |
BLK |
0.707 | -0.073 | -1 | 0.786 |
INSRR |
0.707 | -0.142 | 3 | 0.738 |
HCK |
0.707 | -0.142 | -1 | 0.790 |
FLT3 |
0.706 | -0.173 | 3 | 0.797 |
TEK |
0.706 | -0.049 | 3 | 0.728 |
PDGFRB |
0.706 | -0.197 | 3 | 0.800 |
ITK |
0.705 | -0.145 | -1 | 0.758 |
MET |
0.705 | -0.104 | 3 | 0.779 |
WEE1_TYR |
0.704 | -0.085 | -1 | 0.719 |
FER |
0.703 | -0.209 | 1 | 0.261 |
PDGFRA |
0.702 | -0.194 | 3 | 0.798 |
EPHA4 |
0.700 | -0.130 | 2 | 0.714 |
BMX |
0.700 | -0.117 | -1 | 0.685 |
DDR2 |
0.700 | -0.035 | 3 | 0.711 |
FYN |
0.699 | -0.073 | -1 | 0.794 |
SRMS |
0.699 | -0.202 | 1 | 0.231 |
EPHB1 |
0.699 | -0.202 | 1 | 0.238 |
FGFR3 |
0.699 | -0.089 | 3 | 0.737 |
FLT1 |
0.699 | -0.133 | -1 | 0.777 |
AXL |
0.698 | -0.194 | 3 | 0.762 |
MERTK |
0.697 | -0.181 | 3 | 0.761 |
EPHB3 |
0.697 | -0.192 | -1 | 0.755 |
ALK |
0.696 | -0.165 | 3 | 0.708 |
EPHB2 |
0.696 | -0.184 | -1 | 0.749 |
BTK |
0.695 | -0.222 | -1 | 0.723 |
TEC |
0.695 | -0.171 | -1 | 0.685 |
ERBB2 |
0.695 | -0.175 | 1 | 0.264 |
CK1G3 |
0.693 | -0.045 | -3 | 0.401 |
FRK |
0.692 | -0.168 | -1 | 0.773 |
FLT4 |
0.691 | -0.177 | 3 | 0.720 |
LTK |
0.691 | -0.188 | 3 | 0.721 |
EGFR |
0.691 | -0.119 | 1 | 0.221 |
EPHA1 |
0.690 | -0.180 | 3 | 0.752 |
PTK6 |
0.690 | -0.221 | -1 | 0.698 |
INSR |
0.690 | -0.178 | 3 | 0.718 |
NTRK3 |
0.689 | -0.162 | -1 | 0.726 |
NTRK1 |
0.689 | -0.238 | -1 | 0.765 |
EPHA7 |
0.688 | -0.168 | 2 | 0.724 |
LYN |
0.688 | -0.159 | 3 | 0.691 |
SRC |
0.688 | -0.124 | -1 | 0.779 |
NTRK2 |
0.687 | -0.240 | 3 | 0.731 |
YANK2 |
0.687 | -0.087 | 2 | 0.387 |
MUSK |
0.685 | -0.146 | 1 | 0.212 |
MATK |
0.685 | -0.128 | -1 | 0.668 |
PTK2B |
0.685 | -0.144 | -1 | 0.720 |
SYK |
0.685 | -0.074 | -1 | 0.744 |
EPHA3 |
0.685 | -0.187 | 2 | 0.686 |
ZAP70 |
0.684 | -0.029 | -1 | 0.680 |
FGFR4 |
0.684 | -0.128 | -1 | 0.712 |
PTK2 |
0.682 | -0.068 | -1 | 0.767 |
EPHA8 |
0.681 | -0.151 | -1 | 0.748 |
CSK |
0.681 | -0.179 | 2 | 0.720 |
EPHA5 |
0.678 | -0.188 | 2 | 0.697 |
ERBB4 |
0.676 | -0.103 | 1 | 0.209 |
CK1G2 |
0.675 | -0.046 | -3 | 0.497 |
IGF1R |
0.671 | -0.177 | 3 | 0.647 |
EPHA2 |
0.671 | -0.163 | -1 | 0.717 |
FES |
0.657 | -0.179 | -1 | 0.669 |