Motif 171 (n=203)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NHQ4 | EPOP | S179 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
| A6NHQ4 | EPOP | S180 | ochoa | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation. {ECO:0000250|UniProtKB:Q7TNS8}. |
| E9PAV3 | NACA | S855 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| E9PAV3 | NACA | S1487 | ochoa | Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) | Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}. |
| H0YIS7 | RNASEK-C17orf49 | S147 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. {ECO:0000256|ARBA:ARBA00059556}. |
| O00479 | HMGN4 | S29 | ochoa | High mobility group nucleosome-binding domain-containing protein 4 (Non-histone chromosomal protein HMG-17-like 3) (Non-histone chromosomal protein) | None |
| O14640 | DVL1 | Y651 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14686 | KMT2D | S609 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S618 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S4624 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14686 | KMT2D | S4625 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15085 | ARHGEF11 | S146 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15117 | FYB1 | S388 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15126 | SCAMP1 | S41 | ochoa | Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| O15164 | TRIM24 | S98 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15417 | TNRC18 | S1028 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O15417 | TNRC18 | S1029 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43426 | SYNJ1 | S1073 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43439 | CBFA2T2 | S43 | ochoa | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. |
| O43516 | WIPF1 | S137 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O43516 | WIPF1 | S340 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O43516 | WIPF1 | S412 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
| O60244 | MED14 | S998 | ochoa | Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
| O60292 | SIPA1L3 | S1692 | ochoa | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}. |
| O60307 | MAST3 | S1180 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O60307 | MAST3 | S1182 | ochoa | Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) | None |
| O75081 | CBFA2T3 | S328 | ochoa | Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}. |
| O75376 | NCOR1 | S2394 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75864 | PPP1R37 | S586 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O75962 | TRIO | S2367 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94887 | FARP2 | S457 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3) | Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}. |
| O95359 | TACC2 | S2440 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95835 | LATS1 | S244 | ochoa | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| O96013 | PAK4 | S267 | ochoa | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}. |
| P01859 | IGHG2 | S118 | ochoa | Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE) | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| P04626 | ERBB2 | Y1221 | psp | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. |
| P05204 | HMGN2 | S29 | ochoa|psp | Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}. |
| P09874 | PARP1 | S364 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P14317 | HCLS1 | S299 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P17483 | HOXB4 | S115 | ochoa | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P18669 | PGAM1 | S118 | ochoa|psp | Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) | Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202). {ECO:0000269|PubMed:23653202}. |
| P22681 | CBL | S492 | ochoa | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:P22682, ECO:0000269|PubMed:10514377, ECO:0000269|PubMed:11896602, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:14739300, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:17094949, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19689429, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:28381567}. |
| P23588 | EIF4B | S71 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P25054 | APC | S1436 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P26651 | ZFP36 | S66 | psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P38159 | RBMX | S142 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P38159 | RBMX | S143 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
| P41162 | ETV3 | S132 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P46821 | MAP1B | S2126 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48634 | PRRC2A | S516 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | S823 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48634 | PRRC2A | T1133 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P49137 | MAPKAPK2 | T25 | psp | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}. |
| P54725 | RAD23A | S99 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P54792 | DVL1P1 | Y626 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P56945 | BCAR1 | Y128 | ochoa|psp | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P56945 | BCAR1 | Y362 | ochoa|psp | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
| P61978 | HNRNPK | S284 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
| P78559 | MAP1A | S2171 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q03164 | KMT2A | S1837 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q04323 | UBXN1 | S182 | ochoa | UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein) | Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Also prevents the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. {ECO:0000269|PubMed:20351172, ECO:0000269|PubMed:23545497, ECO:0000269|PubMed:25681446, ECO:0000269|PubMed:28152074}. |
| Q07666 | KHDRBS1 | S58 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q07889 | SOS1 | S1254 | ochoa | Son of sevenless homolog 1 (SOS-1) | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). {ECO:0000250|UniProtKB:Q62245, ECO:0000269|PubMed:17339331, ECO:0000269|PubMed:8493579}. |
| Q0JRZ9 | FCHO2 | S478 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Q12774 | ARHGEF5 | Y836 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12968 | NFATC3 | S247 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13443 | ADAM9 | S798 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
| Q13796 | SHROOM2 | S313 | ochoa | Protein Shroom2 (Apical-like protein) (Protein APXL) | May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}. |
| Q14135 | VGLL4 | S42 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14157 | UBAP2L | S445 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14184 | DOC2B | S34 | psp | Double C2-like domain-containing protein beta (Doc2-beta) | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9804756}. |
| Q14202 | ZMYM3 | T814 | ochoa | Zinc finger MYM-type protein 3 (Zinc finger protein 261) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q14978 | NOLC1 | Y289 | ochoa|psp | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15648 | MED1 | S1049 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15651 | HMGN3 | S31 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
| Q15654 | TRIP6 | Y123 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15654 | TRIP6 | T133 | ochoa | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. {ECO:0000269|PubMed:14688263, ECO:0000269|PubMed:15489293, ECO:0000269|PubMed:16624523, ECO:0000269|PubMed:19017743}. |
| Q15772 | SPEG | S2802 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q16204 | CCDC6 | T434 | psp | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q16584 | MAP3K11 | S748 | ochoa | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q1W6H9 | FAM110C | S174 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q27J81 | INF2 | S419 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q27J81 | INF2 | S434 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2KHR2 | RFX7 | S424 | ochoa | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250|UniProtKB:A0A1L8H0H2, ECO:0000269|PubMed:29967452, ECO:0000269|PubMed:34197623}. |
| Q3KQU3 | MAP7D1 | S41 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3KQU3 | MAP7D1 | S93 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4KMQ1 | TPRN | S269 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q5HYK7 | SH3D19 | S148 | ochoa | SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP) | May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:14551139, ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. |
| Q5JSH3 | WDR44 | S227 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5SYE7 | NHSL1 | S1191 | ochoa | NHS-like protein 1 | None |
| Q5VT52 | RPRD2 | S1213 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q63HR2 | TNS2 | Y483 | ochoa|psp | Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase) | Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250|UniProtKB:Q8CGB6, ECO:0000269|PubMed:15817639, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:23401856, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28955049, ECO:0000269|PubMed:30092354}. |
| Q68EM7 | ARHGAP17 | S665 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6DD87 | ZNF787 | S46 | ochoa | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q6F5E8 | CARMIL2 | S987 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ23 | PLEKHA7 | S571 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ23 | PLEKHA7 | S856 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6IQ23 | PLEKHA7 | S858 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6NYC8 | PPP1R18 | S432 | ochoa | Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18) | [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:24434620}.; FUNCTION: [Isoform 4]: May target protein phosphatase 1 to F-actin cytoskeleton. {ECO:0000269|PubMed:17374523}. |
| Q6PKG0 | LARP1 | S766 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6PKG0 | LARP1 | S1067 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6ZRI6 | C15orf39 | S467 | ochoa | Uncharacterized protein C15orf39 | None |
| Q6ZUJ8 | PIK3AP1 | S757 | ochoa | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269|PubMed:15893754}. |
| Q70E73 | RAPH1 | S1071 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q75N03 | CBLL1 | S201 | ochoa | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. |
| Q7RTP6 | MICAL3 | S1457 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z5L9 | IRF2BP2 | S395 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z5L9 | IRF2BP2 | S396 | ochoa | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q86VM9 | ZC3H18 | S790 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q86X29 | LSR | Y328 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86XL3 | ANKLE2 | S45 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YD1 | PTOV1 | S34 | ochoa | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
| Q86YP4 | GATAD2A | S185 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q86YW5 | TREML1 | S263 | ochoa | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}. |
| Q8IX07 | ZFPM1 | S52 | ochoa | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}. |
| Q8IXM2 | BACC1 | S106 | ochoa | BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) | Component of chromatin complexes such as the MLL1/MLL and NURF complexes. |
| Q8IYB3 | SRRM1 | T614 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IYB3 | SRRM1 | S694 | ochoa | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q8IZ21 | PHACTR4 | S342 | ochoa | Phosphatase and actin regulator 4 | Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}. |
| Q8IZL8 | PELP1 | T647 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8IZL8 | PELP1 | S658 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8IZL8 | PELP1 | S743 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8IZP0 | ABI1 | S392 | psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N0Y7 | PGAM4 | S118 | ochoa | Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4) | None |
| Q8N163 | CCAR2 | S25 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N3F8 | MICALL1 | S309 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3F8 | MICALL1 | S311 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N684 | CPSF7 | S47 | ochoa | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:17024186, PubMed:29276085, PubMed:8626397). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:17024186, PubMed:8626397). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in RNA substrates (PubMed:17024186, PubMed:8626397). {ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085, ECO:0000269|PubMed:8626397}. |
| Q8NDT2 | RBM15B | S113 | ochoa | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}. |
| Q8NDX5 | PHC3 | S658 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEZ4 | KMT2C | S1887 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NEZ4 | KMT2C | S2935 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8TAQ2 | SMARCC2 | S969 | psp | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TD55 | PLEKHO2 | S356 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TE67 | EPS8L3 | S214 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
| Q8TE68 | EPS8L1 | S552 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}. |
| Q8TF74 | WIPF2 | S174 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8TF74 | WIPF2 | Y255 | ochoa | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. |
| Q8WWM7 | ATXN2L | S45 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWM7 | ATXN2L | S630 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WX93 | PALLD | S684 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WX93 | PALLD | S688 | ochoa|psp | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE0 | CASKIN2 | S368 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WXE0 | CASKIN2 | S720 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WXE0 | CASKIN2 | S877 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q92610 | ZNF592 | S687 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92610 | ZNF592 | S689 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q93052 | LPP | Y273 | ochoa | Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) | May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}. |
| Q969T9 | WBP2 | Y192 | psp | WW domain-binding protein 2 (WBP-2) | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). {ECO:0000250|UniProtKB:P97765, ECO:0000269|PubMed:16772533}. |
| Q96D31 | ORAI1 | S34 | psp | Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) | Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable) (PubMed:16645049, PubMed:16733527, PubMed:16807233, PubMed:16921383, PubMed:19249086, PubMed:19706554, PubMed:23307288, PubMed:26956484, PubMed:28219928). Assembles with ORAI2 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (PubMed:16582901, PubMed:17442569, PubMed:19182790, PubMed:20354224, PubMed:22641696, PubMed:26221052, PubMed:32415068, PubMed:33941685). Assembles with ORAI3 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (PubMed:19622606, PubMed:32415068). Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion (By similarity) (PubMed:20887894). {ECO:0000250|UniProtKB:Q8BWG9, ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:20354224, ECO:0000269|PubMed:20887894, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:26956484, ECO:0000269|PubMed:28219928, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685, ECO:0000305|PubMed:16766533}.; FUNCTION: [Isoform alpha]: Pore-forming subunit of both CRAC and ARC channels. Couples Ca(2+) influx to NFAT-mediated transcriptional responses. {ECO:0000269|PubMed:16921383, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:19622606, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}.; FUNCTION: [Isoform beta]: Pore-forming subunit of CRAC channels exclusively. {ECO:0000269|PubMed:22641696, ECO:0000269|PubMed:26221052, ECO:0000269|PubMed:33941685}. |
| Q96DN6 | MBD6 | S211 | ochoa | Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6) | Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth (PubMed:36180891). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:36180891}. |
| Q96E39 | RBMXL1 | S142 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96E39 | RBMXL1 | S143 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96EP0 | RNF31 | S450 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
| Q96HA1 | POM121 | S174 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96I24 | FUBP3 | S442 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96J02 | ITCH | S257 | psp | E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1) | Acts as an Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11046148, PubMed:14602072, PubMed:15051726, PubMed:16387660, PubMed:17028573, PubMed:18718448, PubMed:18718449, PubMed:19116316, PubMed:19592251, PubMed:19881509, PubMed:20068034, PubMed:20392206, PubMed:20491914, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:19131965). This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1 (PubMed:19131965). Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways (PubMed:19592251). Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response (PubMed:18718448, PubMed:20491914). Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages (PubMed:18718448). Mediates JUN ubiquitination and degradation (By similarity). Mediates JUNB ubiquitination and degradation (PubMed:16387660). Critical regulator of type 2 helper T (Th2) cell cytokine production by inducing JUNB ubiquitination and degradation (By similarity). Involved in the negative regulation of MAVS-dependent cellular antiviral responses (PubMed:19881509). Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation (PubMed:19881509). Following ligand stimulation, regulates sorting of Wnt receptor FZD4 to the degradative endocytic pathway probably by modulating PI42KA activity (PubMed:23146885). Ubiquitinates PI4K2A and negatively regulates its catalytic activity (PubMed:23146885). Ubiquitinates chemokine receptor CXCR4 and regulates sorting of CXCR4 to the degradative endocytic pathway following ligand stimulation by ubiquitinating endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:14602072, PubMed:23146885, PubMed:34927784). Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination (PubMed:17028573, PubMed:18628966, PubMed:23886940). Ubiquitinates SNX9 (PubMed:20491914). Ubiquitinates MAP3K7 through 'Lys-48'-linked conjugation (By similarity). Together with UBR5, involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP: catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP (PubMed:20068034, PubMed:29378950). ITCH synthesizes 'Lys-63'-linked chains, while UBR5 is branching multiple 'Lys-48'-linked chains of substrate initially modified (PubMed:29378950). Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID (PubMed:20392206). Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Inhibits the replication of influenza A virus (IAV) via ubiquitination of IAV matrix protein 1 (M1) through 'Lys-48'-linked conjugation resulting in M1 proteasomal degradation (PubMed:30328013). Ubiquitinates NEDD9/HEF1, resulting in proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). {ECO:0000250|UniProtKB:Q8C863, ECO:0000269|PubMed:14602072, ECO:0000269|PubMed:15051726, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:17028573, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:18718448, ECO:0000269|PubMed:18718449, ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:19131965, ECO:0000269|PubMed:19592251, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:20491914, ECO:0000269|PubMed:23146885, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:30328013}. |
| Q96JM3 | CHAMP1 | S284 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96JM3 | CHAMP1 | S328 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96MS0 | ROBO3 | S1263 | ochoa | Roundabout homolog 3 (Roundabout-like protein 3) | Receptor involved in axon guidance during development (PubMed:15105459). Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (By similarity). {ECO:0000250|UniProtKB:Q9Z2I4, ECO:0000269|PubMed:15105459}. |
| Q96ST3 | SIN3A | S263 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96ST3 | SIN3A | Y272 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q99490 | AGAP2 | S279 | psp | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99700 | ATXN2 | S565 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99700 | ATXN2 | S600 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9BUL9 | RPP25 | Y151 | ochoa | Ribonuclease P protein subunit p25 (RNase P protein subunit p25) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:12003489, ECO:0000269|PubMed:16723659, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}. |
| Q9BVA0 | KATNB1 | S400 | ochoa | Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}. |
| Q9BW04 | SARG | Y259 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX66 | SORBS1 | S240 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXP5 | SRRT | Y798 | psp | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:19632182}. |
| Q9BYB0 | SHANK3 | S902 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9H3T3 | SEMA6B | S812 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H792 | PEAK1 | S861 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7P9 | PLEKHG2 | S1317 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
| Q9H987 | SYNPO2L | S790 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HC35 | EML4 | S895 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCD6 | TANC2 | Y1528 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9NQC3 | RTN4 | S150 | ochoa | Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) | Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}. |
| Q9NR12 | PDLIM7 | S217 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NW07 | ZNF358 | S484 | ochoa | Zinc finger protein 358 | May be involved in transcriptional regulation. |
| Q9P206 | NHSL3 | S677 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P206 | NHSL3 | S971 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9UBW5 | BIN2 | S411 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UDY2 | TJP2 | S1031 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UGK3 | STAP2 | S293 | ochoa | Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate) | Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}. |
| Q9UHG2 | PCSK1N | S44 | ochoa | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}. |
| Q9UKY7 | CDV3 | S166 | ochoa | Protein CDV3 homolog | None |
| Q9UM47 | NOTCH3 | S2203 | ochoa | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). {ECO:0000250|UniProtKB:Q9R172, ECO:0000269|PubMed:15350543}. |
| Q9UMN6 | KMT2B | S560 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMS6 | SYNPO2 | S623 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
| Q9UPN4 | CEP131 | S21 | ochoa|psp | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UPS6 | SETD1B | T377 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
| Q9UPY6 | WASF3 | Y337 | psp | Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}. |
| Q9UQ35 | SRRM2 | S358 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQQ2 | SH2B3 | S103 | ochoa | SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. |
| Q9Y3Q8 | TSC22D4 | S28 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4B5 | MTCL1 | S1302 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H4 | GPSM3 | S35 | ochoa|psp | G-protein-signaling modulator 3 (Activator of G-protein signaling 4) (G18.1b) (Protein G18) | Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. {ECO:0000269|PubMed:14656218, ECO:0000269|PubMed:15096500}. |
| Q9Y613 | FHOD1 | S580 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y6N7 | ROBO1 | Y1476 | ochoa | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). {ECO:0000250|UniProtKB:O89026, ECO:0000269|PubMed:10102268, ECO:0000269|PubMed:24560577, ECO:0000269|PubMed:26529257, ECO:0000305}. |
| Q9Y6W5 | WASF2 | S298 | ochoa | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q13435 | SF3B2 | Y639 | Sugiyama | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| P49023 | PXN | Y40 | GPS6|ELM|iPTMNet|EPSD | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000003 | 5.518 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.000019 | 4.714 |
| R-HSA-8848021 | Signaling by PTK6 | 0.000019 | 4.714 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000028 | 4.552 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.000101 | 3.997 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000130 | 3.887 |
| R-HSA-73887 | Death Receptor Signaling | 0.000171 | 3.768 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.000239 | 3.621 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.000287 | 3.543 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.000354 | 3.451 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.000484 | 3.315 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.000591 | 3.229 |
| R-HSA-428540 | Activation of RAC1 | 0.000705 | 3.152 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.000839 | 3.076 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.001189 | 2.925 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.001842 | 2.735 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.002211 | 2.655 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.002211 | 2.655 |
| R-HSA-422475 | Axon guidance | 0.002087 | 2.681 |
| R-HSA-9675108 | Nervous system development | 0.003764 | 2.424 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.003712 | 2.430 |
| R-HSA-162582 | Signal Transduction | 0.005270 | 2.278 |
| R-HSA-194138 | Signaling by VEGF | 0.005483 | 2.261 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.008368 | 2.077 |
| R-HSA-9664407 | Parasite infection | 0.009339 | 2.030 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.009339 | 2.030 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.009339 | 2.030 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.008762 | 2.057 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.009613 | 2.017 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.011239 | 1.949 |
| R-HSA-4839726 | Chromatin organization | 0.012050 | 1.919 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.014446 | 1.840 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.013766 | 1.861 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.014446 | 1.840 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.014446 | 1.840 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.014446 | 1.840 |
| R-HSA-8853659 | RET signaling | 0.013201 | 1.879 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.019927 | 1.701 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.023989 | 1.620 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.021222 | 1.673 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.022155 | 1.655 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.022155 | 1.655 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.022155 | 1.655 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.023246 | 1.634 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.021919 | 1.659 |
| R-HSA-373752 | Netrin-1 signaling | 0.021700 | 1.664 |
| R-HSA-9607240 | FLT3 Signaling | 0.017631 | 1.754 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.023989 | 1.620 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.020639 | 1.685 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.020424 | 1.690 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.028359 | 1.547 |
| R-HSA-2028269 | Signaling by Hippo | 0.026137 | 1.583 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.026137 | 1.583 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.026137 | 1.583 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.026137 | 1.583 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.028359 | 1.547 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.028810 | 1.540 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.044208 | 1.355 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.044208 | 1.355 |
| R-HSA-8985801 | Regulation of cortical dendrite branching | 0.044208 | 1.355 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.044208 | 1.355 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.044208 | 1.355 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.044208 | 1.355 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.044208 | 1.355 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.044208 | 1.355 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.044208 | 1.355 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.044208 | 1.355 |
| R-HSA-4755609 | Defective DHDDS causes RP59 | 0.044208 | 1.355 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.044208 | 1.355 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.044208 | 1.355 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.040527 | 1.392 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.040527 | 1.392 |
| R-HSA-72172 | mRNA Splicing | 0.042983 | 1.367 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.035074 | 1.455 |
| R-HSA-177929 | Signaling by EGFR | 0.036720 | 1.435 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.037959 | 1.421 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.044208 | 1.355 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.033021 | 1.481 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.035456 | 1.450 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.035456 | 1.450 |
| R-HSA-167044 | Signalling to RAS | 0.035456 | 1.450 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.037959 | 1.421 |
| R-HSA-1266738 | Developmental Biology | 0.035205 | 1.453 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.044922 | 1.348 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.045853 | 1.339 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.054952 | 1.260 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.054952 | 1.260 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.054952 | 1.260 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.065577 | 1.183 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 0.065577 | 1.183 |
| R-HSA-1306955 | GRB7 events in ERBB2 signaling | 0.065577 | 1.183 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.076083 | 1.119 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.076083 | 1.119 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 0.086471 | 1.063 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 0.086471 | 1.063 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.086471 | 1.063 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.106901 | 0.971 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 0.106901 | 0.971 |
| R-HSA-112412 | SOS-mediated signalling | 0.106901 | 0.971 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.126876 | 0.897 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.126876 | 0.897 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.126876 | 0.897 |
| R-HSA-4839744 | Signaling by APC mutants | 0.146407 | 0.834 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.146407 | 0.834 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.146407 | 0.834 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.146407 | 0.834 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.156008 | 0.807 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.156008 | 0.807 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.165503 | 0.781 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.165503 | 0.781 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.165503 | 0.781 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.165503 | 0.781 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.165503 | 0.781 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.165503 | 0.781 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.165503 | 0.781 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.174891 | 0.757 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.060195 | 1.220 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.063226 | 1.199 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.184174 | 0.735 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.184174 | 0.735 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.193353 | 0.714 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.193353 | 0.714 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.193353 | 0.714 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.075843 | 1.120 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.220279 | 0.657 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.220279 | 0.657 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.237731 | 0.624 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.237731 | 0.624 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.246311 | 0.609 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.271479 | 0.566 |
| R-HSA-72187 | mRNA 3'-end processing | 0.148034 | 0.830 |
| R-HSA-429947 | Deadenylation of mRNA | 0.287791 | 0.541 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.179775 | 0.745 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.233108 | 0.632 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.253911 | 0.595 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.270586 | 0.568 |
| R-HSA-1989781 | PPARA activates gene expression | 0.311155 | 0.507 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.137909 | 0.860 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.303740 | 0.517 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.179775 | 0.745 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.099596 | 1.002 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.278922 | 0.555 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.211405 | 0.675 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.295810 | 0.529 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.295810 | 0.529 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.054290 | 1.265 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.079113 | 1.102 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.096086 | 1.017 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.121968 | 0.914 |
| R-HSA-8849473 | PTK6 Expression | 0.106901 | 0.971 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.126876 | 0.897 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.063226 | 1.199 |
| R-HSA-9664420 | Killing mechanisms | 0.202430 | 0.694 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.202430 | 0.694 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.110335 | 0.957 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.193353 | 0.714 |
| R-HSA-8851805 | MET activates RAS signaling | 0.165503 | 0.781 |
| R-HSA-9930044 | Nuclear RNA decay | 0.072618 | 1.139 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.211405 | 0.675 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.263184 | 0.580 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.159803 | 0.796 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.311580 | 0.506 |
| R-HSA-74749 | Signal attenuation | 0.136696 | 0.864 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.263184 | 0.580 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.274403 | 0.562 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.063226 | 1.199 |
| R-HSA-9843745 | Adipogenesis | 0.086613 | 1.062 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.291414 | 0.535 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.054952 | 1.260 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 0.116944 | 0.932 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 0.146407 | 0.834 |
| R-HSA-192814 | vRNA Synthesis | 0.146407 | 0.834 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.156008 | 0.807 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 0.156008 | 0.807 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.156008 | 0.807 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.156008 | 0.807 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.060195 | 1.220 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.193353 | 0.714 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.202430 | 0.694 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.202430 | 0.694 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.211405 | 0.675 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 0.254795 | 0.594 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 0.263184 | 0.580 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.287791 | 0.541 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 0.311580 | 0.506 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.183815 | 0.736 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.228959 | 0.640 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.087240 | 1.059 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 0.076083 | 1.119 |
| R-HSA-9909396 | Circadian clock | 0.235197 | 0.629 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.076083 | 1.119 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.116944 | 0.932 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.229054 | 0.640 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.224815 | 0.648 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.112260 | 0.950 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.193353 | 0.714 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.246311 | 0.609 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.116944 | 0.932 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.146407 | 0.834 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 0.165503 | 0.781 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.072618 | 1.139 |
| R-HSA-139853 | Elevation of cytosolic Ca2+ levels | 0.220279 | 0.657 |
| R-HSA-9707616 | Heme signaling | 0.187869 | 0.726 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 0.126876 | 0.897 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.174891 | 0.757 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.125094 | 0.903 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.193353 | 0.714 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.319333 | 0.496 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.326999 | 0.485 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.137078 | 0.863 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.311155 | 0.507 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.169041 | 0.772 |
| R-HSA-157118 | Signaling by NOTCH | 0.173094 | 0.762 |
| R-HSA-8964046 | VLDL clearance | 0.106901 | 0.971 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.136696 | 0.864 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.156008 | 0.807 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.184174 | 0.735 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.254795 | 0.594 |
| R-HSA-75893 | TNF signaling | 0.163764 | 0.786 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.056239 | 1.250 |
| R-HSA-9658195 | Leishmania infection | 0.056239 | 1.250 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.106722 | 0.972 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.287791 | 0.541 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.303740 | 0.517 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.262247 | 0.581 |
| R-HSA-8953854 | Metabolism of RNA | 0.062297 | 1.206 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.139931 | 0.854 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.051421 | 1.289 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 0.165503 | 0.781 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.193353 | 0.714 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.193353 | 0.714 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.187869 | 0.726 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.193353 | 0.714 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.303740 | 0.517 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.084446 | 1.073 |
| R-HSA-199920 | CREB phosphorylation | 0.096743 | 1.014 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 0.116944 | 0.932 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.136696 | 0.864 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.165503 | 0.781 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.193353 | 0.714 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.151937 | 0.818 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.326999 | 0.485 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.262247 | 0.581 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.048608 | 1.313 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.237731 | 0.624 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 0.263184 | 0.580 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 0.271479 | 0.566 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.295810 | 0.529 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 0.319333 | 0.496 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.113979 | 0.943 |
| R-HSA-6806834 | Signaling by MET | 0.262247 | 0.581 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.110335 | 0.957 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.121360 | 0.916 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.086471 | 1.063 |
| R-HSA-171007 | p38MAPK events | 0.193353 | 0.714 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.179775 | 0.745 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.262247 | 0.581 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.066872 | 1.175 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.228959 | 0.640 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.303740 | 0.517 |
| R-HSA-186763 | Downstream signal transduction | 0.066308 | 1.178 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.163764 | 0.786 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.069439 | 1.158 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.271479 | 0.566 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.326999 | 0.485 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.283088 | 0.548 |
| R-HSA-3371556 | Cellular response to heat stress | 0.197149 | 0.705 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.237262 | 0.625 |
| R-HSA-373755 | Semaphorin interactions | 0.047395 | 1.324 |
| R-HSA-397014 | Muscle contraction | 0.268214 | 0.572 |
| R-HSA-5689877 | Josephin domain DUBs | 0.136696 | 0.864 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.193353 | 0.714 |
| R-HSA-354192 | Integrin signaling | 0.072618 | 1.139 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.279681 | 0.553 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.204198 | 0.690 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.105184 | 0.978 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.303740 | 0.517 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.121360 | 0.916 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.072618 | 1.139 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.089177 | 1.050 |
| R-HSA-210993 | Tie2 Signaling | 0.229054 | 0.640 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.103142 | 0.987 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.184174 | 0.735 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.254795 | 0.594 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.245581 | 0.610 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.106901 | 0.971 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.271479 | 0.566 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.287791 | 0.541 |
| R-HSA-74160 | Gene expression (Transcription) | 0.317506 | 0.498 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.303740 | 0.517 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.263184 | 0.580 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.311580 | 0.506 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.312168 | 0.506 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.116944 | 0.932 |
| R-HSA-9842663 | Signaling by LTK | 0.165503 | 0.781 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.184174 | 0.735 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.193353 | 0.714 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.263184 | 0.580 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.163764 | 0.786 |
| R-HSA-186797 | Signaling by PDGF | 0.187869 | 0.726 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.085781 | 1.067 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.311580 | 0.506 |
| R-HSA-187687 | Signalling to ERKs | 0.082426 | 1.084 |
| R-HSA-73884 | Base Excision Repair | 0.308026 | 0.511 |
| R-HSA-180292 | GAB1 signalosome | 0.229054 | 0.640 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.124098 | 0.906 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.287791 | 0.541 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.326999 | 0.485 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.271479 | 0.566 |
| R-HSA-9833110 | RSV-host interactions | 0.144863 | 0.839 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.303740 | 0.517 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.124441 | 0.905 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.160778 | 0.794 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.270698 | 0.568 |
| R-HSA-212436 | Generic Transcription Pathway | 0.323859 | 0.490 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.326999 | 0.485 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.266417 | 0.574 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.165503 | 0.781 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.069439 | 1.158 |
| R-HSA-9830364 | Formation of the nephric duct | 0.295810 | 0.529 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.174891 | 0.757 |
| R-HSA-8964038 | LDL clearance | 0.271479 | 0.566 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.326532 | 0.486 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.117655 | 0.929 |
| R-HSA-75153 | Apoptotic execution phase | 0.125094 | 0.903 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.287791 | 0.541 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.253182 | 0.597 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.328681 | 0.483 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.334580 | 0.476 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.334580 | 0.476 |
| R-HSA-2424491 | DAP12 signaling | 0.334580 | 0.476 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.334580 | 0.476 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.334580 | 0.476 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.342075 | 0.466 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.342075 | 0.466 |
| R-HSA-182971 | EGFR downregulation | 0.342075 | 0.466 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.342075 | 0.466 |
| R-HSA-190236 | Signaling by FGFR | 0.349169 | 0.457 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.349486 | 0.457 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.356814 | 0.448 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.356814 | 0.448 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.356814 | 0.448 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.356814 | 0.448 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.356814 | 0.448 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.356814 | 0.448 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.356814 | 0.448 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.356814 | 0.448 |
| R-HSA-70171 | Glycolysis | 0.357307 | 0.447 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.360328 | 0.443 |
| R-HSA-390522 | Striated Muscle Contraction | 0.364061 | 0.439 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.364061 | 0.439 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.364061 | 0.439 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.365408 | 0.437 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.365408 | 0.437 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.371226 | 0.430 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.371226 | 0.430 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.371226 | 0.430 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.371226 | 0.430 |
| R-HSA-5673000 | RAF activation | 0.371226 | 0.430 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.371226 | 0.430 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.371226 | 0.430 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.373471 | 0.428 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.375622 | 0.425 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.378310 | 0.422 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.378310 | 0.422 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.378310 | 0.422 |
| R-HSA-5663205 | Infectious disease | 0.379921 | 0.420 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.381493 | 0.419 |
| R-HSA-168255 | Influenza Infection | 0.387807 | 0.411 |
| R-HSA-4641258 | Degradation of DVL | 0.392242 | 0.406 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.392242 | 0.406 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.392242 | 0.406 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.393443 | 0.405 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.393443 | 0.405 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.393443 | 0.405 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.399092 | 0.399 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.399092 | 0.399 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.399935 | 0.398 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.405864 | 0.392 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.405864 | 0.392 |
| R-HSA-201556 | Signaling by ALK | 0.405864 | 0.392 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.405864 | 0.392 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.405864 | 0.392 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.409213 | 0.388 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.410218 | 0.387 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.412561 | 0.385 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.412561 | 0.385 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.412561 | 0.385 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.412561 | 0.385 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.412561 | 0.385 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.412561 | 0.385 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.412561 | 0.385 |
| R-HSA-202433 | Generation of second messenger molecules | 0.412561 | 0.385 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.412561 | 0.385 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.415003 | 0.382 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.419182 | 0.378 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.419182 | 0.378 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.425729 | 0.371 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.425729 | 0.371 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.428641 | 0.368 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.432203 | 0.364 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.432203 | 0.364 |
| R-HSA-73928 | Depyrimidination | 0.432203 | 0.364 |
| R-HSA-165159 | MTOR signalling | 0.432203 | 0.364 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.432487 | 0.364 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.432487 | 0.364 |
| R-HSA-70326 | Glucose metabolism | 0.436319 | 0.360 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.436319 | 0.360 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.438604 | 0.358 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.440138 | 0.356 |
| R-HSA-2172127 | DAP12 interactions | 0.444934 | 0.352 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.444934 | 0.352 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.444934 | 0.352 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 0.444934 | 0.352 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.451192 | 0.346 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.451192 | 0.346 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.457380 | 0.340 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.457380 | 0.340 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.457380 | 0.340 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.457380 | 0.340 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.457380 | 0.340 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.457380 | 0.340 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.459015 | 0.338 |
| R-HSA-5357801 | Programmed Cell Death | 0.468141 | 0.330 |
| R-HSA-70263 | Gluconeogenesis | 0.469550 | 0.328 |
| R-HSA-9766229 | Degradation of CDH1 | 0.475532 | 0.323 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.475532 | 0.323 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.475532 | 0.323 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.477484 | 0.321 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.481175 | 0.318 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.481447 | 0.317 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.488438 | 0.311 |
| R-HSA-1474165 | Reproduction | 0.492046 | 0.308 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.493079 | 0.307 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.493079 | 0.307 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.498798 | 0.302 |
| R-HSA-72649 | Translation initiation complex formation | 0.504452 | 0.297 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.504452 | 0.297 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.510043 | 0.292 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.515571 | 0.288 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.515571 | 0.288 |
| R-HSA-5578775 | Ion homeostasis | 0.515571 | 0.288 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.521037 | 0.283 |
| R-HSA-112399 | IRS-mediated signalling | 0.521037 | 0.283 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.521037 | 0.283 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.526442 | 0.279 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.526442 | 0.279 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.526442 | 0.279 |
| R-HSA-6807070 | PTEN Regulation | 0.527233 | 0.278 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.531786 | 0.274 |
| R-HSA-191859 | snRNP Assembly | 0.531786 | 0.274 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.531786 | 0.274 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.531786 | 0.274 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.537070 | 0.270 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.537070 | 0.270 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.537070 | 0.270 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.537070 | 0.270 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.537070 | 0.270 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.540842 | 0.267 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.542295 | 0.266 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.542295 | 0.266 |
| R-HSA-450294 | MAP kinase activation | 0.542295 | 0.266 |
| R-HSA-1442490 | Collagen degradation | 0.542295 | 0.266 |
| R-HSA-72312 | rRNA processing | 0.543521 | 0.265 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.547461 | 0.262 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.547461 | 0.262 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.547461 | 0.262 |
| R-HSA-1643685 | Disease | 0.550217 | 0.259 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.552569 | 0.258 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.552569 | 0.258 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.552569 | 0.258 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.557620 | 0.254 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.557620 | 0.254 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.557620 | 0.254 |
| R-HSA-166520 | Signaling by NTRKs | 0.560746 | 0.251 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.562614 | 0.250 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.562614 | 0.250 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.567243 | 0.246 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.567552 | 0.246 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.572435 | 0.242 |
| R-HSA-9830369 | Kidney development | 0.572435 | 0.242 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.576860 | 0.239 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.577262 | 0.239 |
| R-HSA-5218859 | Regulated Necrosis | 0.577262 | 0.239 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.586551 | 0.232 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.586756 | 0.232 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.586756 | 0.232 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.586756 | 0.232 |
| R-HSA-448424 | Interleukin-17 signaling | 0.586756 | 0.232 |
| R-HSA-9610379 | HCMV Late Events | 0.589439 | 0.230 |
| R-HSA-9609646 | HCMV Infection | 0.590230 | 0.229 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.591423 | 0.228 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.591423 | 0.228 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.591423 | 0.228 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.596037 | 0.225 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.596037 | 0.225 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.596037 | 0.225 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.597371 | 0.224 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.600600 | 0.221 |
| R-HSA-5688426 | Deubiquitination | 0.602652 | 0.220 |
| R-HSA-109581 | Apoptosis | 0.604773 | 0.218 |
| R-HSA-380287 | Centrosome maturation | 0.609572 | 0.215 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.609572 | 0.215 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.613983 | 0.212 |
| R-HSA-5689603 | UCH proteinases | 0.613983 | 0.212 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.618344 | 0.209 |
| R-HSA-4086400 | PCP/CE pathway | 0.622656 | 0.206 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.622656 | 0.206 |
| R-HSA-416476 | G alpha (q) signalling events | 0.624384 | 0.205 |
| R-HSA-73894 | DNA Repair | 0.624706 | 0.204 |
| R-HSA-9659379 | Sensory processing of sound | 0.626919 | 0.203 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.626919 | 0.203 |
| R-HSA-72306 | tRNA processing | 0.631279 | 0.200 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.636979 | 0.196 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.647529 | 0.189 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.647570 | 0.189 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.651513 | 0.186 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.651513 | 0.186 |
| R-HSA-9824446 | Viral Infection Pathways | 0.651781 | 0.186 |
| R-HSA-2559583 | Cellular Senescence | 0.659092 | 0.181 |
| R-HSA-173623 | Classical antibody-mediated complement activation | 0.667007 | 0.176 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.667007 | 0.176 |
| R-HSA-156902 | Peptide chain elongation | 0.667007 | 0.176 |
| R-HSA-3781865 | Diseases of glycosylation | 0.669741 | 0.174 |
| R-HSA-68886 | M Phase | 0.670131 | 0.174 |
| R-HSA-168249 | Innate Immune System | 0.670203 | 0.174 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.674494 | 0.171 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.678175 | 0.169 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.680426 | 0.167 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.681815 | 0.166 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.685413 | 0.164 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.685413 | 0.164 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.685413 | 0.164 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.685413 | 0.164 |
| R-HSA-2029481 | FCGR activation | 0.688971 | 0.162 |
| R-HSA-68877 | Mitotic Prometaphase | 0.692721 | 0.159 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.694968 | 0.158 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.695968 | 0.157 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.695968 | 0.157 |
| R-HSA-195721 | Signaling by WNT | 0.699030 | 0.156 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.699407 | 0.155 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.699407 | 0.155 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.699407 | 0.155 |
| R-HSA-9609690 | HCMV Early Events | 0.700084 | 0.155 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.702808 | 0.153 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.702808 | 0.153 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.709494 | 0.149 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.709494 | 0.149 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.709494 | 0.149 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.709675 | 0.149 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.712782 | 0.147 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.716032 | 0.145 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.716700 | 0.145 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.719245 | 0.143 |
| R-HSA-1483255 | PI Metabolism | 0.722423 | 0.141 |
| R-HSA-192823 | Viral mRNA Translation | 0.725564 | 0.139 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.728670 | 0.137 |
| R-HSA-1500931 | Cell-Cell communication | 0.733769 | 0.134 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.734778 | 0.134 |
| R-HSA-166786 | Creation of C4 and C2 activators | 0.737781 | 0.132 |
| R-HSA-418346 | Platelet homeostasis | 0.737781 | 0.132 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.737781 | 0.132 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.740750 | 0.130 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.740750 | 0.130 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.740750 | 0.130 |
| R-HSA-211000 | Gene Silencing by RNA | 0.740750 | 0.130 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.741048 | 0.130 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.743685 | 0.129 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.746587 | 0.127 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.746587 | 0.127 |
| R-HSA-68882 | Mitotic Anaphase | 0.747626 | 0.126 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.749457 | 0.125 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.749457 | 0.125 |
| R-HSA-202403 | TCR signaling | 0.749457 | 0.125 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.749721 | 0.125 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.755099 | 0.122 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.755099 | 0.122 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.755099 | 0.122 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.757873 | 0.120 |
| R-HSA-166663 | Initial triggering of complement | 0.763327 | 0.117 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.766008 | 0.116 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.768659 | 0.114 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.771798 | 0.112 |
| R-HSA-5693538 | Homology Directed Repair | 0.776433 | 0.110 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.778966 | 0.108 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.778966 | 0.108 |
| R-HSA-68875 | Mitotic Prophase | 0.781471 | 0.107 |
| R-HSA-9679506 | SARS-CoV Infections | 0.782534 | 0.106 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.786396 | 0.104 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.786396 | 0.104 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.788817 | 0.103 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.791211 | 0.102 |
| R-HSA-6798695 | Neutrophil degranulation | 0.791275 | 0.102 |
| R-HSA-977606 | Regulation of Complement cascade | 0.793578 | 0.100 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.798231 | 0.098 |
| R-HSA-388396 | GPCR downstream signalling | 0.798770 | 0.098 |
| R-HSA-114608 | Platelet degranulation | 0.800519 | 0.097 |
| R-HSA-109582 | Hemostasis | 0.809000 | 0.092 |
| R-HSA-5576891 | Cardiac conduction | 0.811576 | 0.091 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.811576 | 0.091 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.813713 | 0.090 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.815826 | 0.088 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.820509 | 0.086 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.824042 | 0.084 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.824042 | 0.084 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.828012 | 0.082 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.828012 | 0.082 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.831143 | 0.080 |
| R-HSA-2262752 | Cellular responses to stress | 0.836232 | 0.078 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.837553 | 0.077 |
| R-HSA-166658 | Complement cascade | 0.843023 | 0.074 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.848309 | 0.071 |
| R-HSA-446728 | Cell junction organization | 0.852048 | 0.070 |
| R-HSA-2142753 | Arachidonate metabolism | 0.855083 | 0.068 |
| R-HSA-1280218 | Adaptive Immune System | 0.857677 | 0.067 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.858357 | 0.066 |
| R-HSA-162587 | HIV Life Cycle | 0.863129 | 0.064 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.863129 | 0.064 |
| R-HSA-9711097 | Cellular response to starvation | 0.864684 | 0.063 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.867742 | 0.062 |
| R-HSA-372790 | Signaling by GPCR | 0.872022 | 0.059 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.873653 | 0.059 |
| R-HSA-5619102 | SLC transporter disorders | 0.877913 | 0.057 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.884697 | 0.053 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.887305 | 0.052 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.887305 | 0.052 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.887305 | 0.052 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.887305 | 0.052 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.889854 | 0.051 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.901337 | 0.045 |
| R-HSA-69275 | G2/M Transition | 0.902883 | 0.044 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.905081 | 0.043 |
| R-HSA-5617833 | Cilium Assembly | 0.907230 | 0.042 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.908286 | 0.042 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.913391 | 0.039 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.916232 | 0.038 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.922489 | 0.035 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.932007 | 0.031 |
| R-HSA-418990 | Adherens junctions interactions | 0.933464 | 0.030 |
| R-HSA-162906 | HIV Infection | 0.939992 | 0.027 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.941354 | 0.026 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.946502 | 0.024 |
| R-HSA-8939211 | ESR-mediated signaling | 0.946502 | 0.024 |
| R-HSA-199991 | Membrane Trafficking | 0.946741 | 0.024 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.947838 | 0.023 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.952308 | 0.021 |
| R-HSA-421270 | Cell-cell junction organization | 0.954451 | 0.020 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.961644 | 0.017 |
| R-HSA-5668914 | Diseases of metabolism | 0.963458 | 0.016 |
| R-HSA-72766 | Translation | 0.964160 | 0.016 |
| R-HSA-168256 | Immune System | 0.966342 | 0.015 |
| R-HSA-1640170 | Cell Cycle | 0.966879 | 0.015 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.968117 | 0.014 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.972193 | 0.012 |
| R-HSA-1483257 | Phospholipid metabolism | 0.972553 | 0.012 |
| R-HSA-449147 | Signaling by Interleukins | 0.978306 | 0.010 |
| R-HSA-8957322 | Metabolism of steroids | 0.980358 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.981884 | 0.008 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.985558 | 0.006 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.990190 | 0.004 |
| R-HSA-913531 | Interferon Signaling | 0.990190 | 0.004 |
| R-HSA-418594 | G alpha (i) signalling events | 0.992574 | 0.003 |
| R-HSA-8978868 | Fatty acid metabolism | 0.992574 | 0.003 |
| R-HSA-597592 | Post-translational protein modification | 0.993521 | 0.003 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.995279 | 0.002 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.996218 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.996348 | 0.002 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999370 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999583 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999866 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999992 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK4 |
0.832 | 0.437 | 1 | 0.820 |
CLK3 |
0.831 | 0.334 | 1 | 0.831 |
HIPK2 |
0.821 | 0.344 | 1 | 0.742 |
DYRK2 |
0.818 | 0.313 | 1 | 0.808 |
SRPK1 |
0.815 | 0.215 | -3 | 0.758 |
KIS |
0.815 | 0.314 | 1 | 0.770 |
CLK2 |
0.812 | 0.259 | -3 | 0.745 |
ERK5 |
0.809 | 0.238 | 1 | 0.880 |
DYRK4 |
0.809 | 0.291 | 1 | 0.752 |
HIPK1 |
0.809 | 0.300 | 1 | 0.811 |
PIM3 |
0.808 | 0.165 | -3 | 0.836 |
CDKL5 |
0.808 | 0.210 | -3 | 0.797 |
COT |
0.807 | 0.116 | 2 | 0.782 |
AURC |
0.807 | 0.219 | -2 | 0.731 |
SKMLCK |
0.807 | 0.211 | -2 | 0.894 |
CDK18 |
0.806 | 0.260 | 1 | 0.728 |
MOS |
0.806 | 0.192 | 1 | 0.795 |
PRKD1 |
0.806 | 0.245 | -3 | 0.843 |
P38B |
0.805 | 0.281 | 1 | 0.773 |
ICK |
0.804 | 0.250 | -3 | 0.841 |
NDR2 |
0.803 | 0.159 | -3 | 0.845 |
CDC7 |
0.803 | 0.087 | 1 | 0.769 |
CDK19 |
0.803 | 0.252 | 1 | 0.728 |
RSK2 |
0.803 | 0.145 | -3 | 0.773 |
NLK |
0.802 | 0.161 | 1 | 0.834 |
CDK7 |
0.802 | 0.225 | 1 | 0.766 |
MAK |
0.802 | 0.334 | -2 | 0.890 |
P38A |
0.801 | 0.266 | 1 | 0.809 |
PRKD2 |
0.801 | 0.205 | -3 | 0.778 |
CDKL1 |
0.801 | 0.143 | -3 | 0.797 |
JNK2 |
0.800 | 0.235 | 1 | 0.726 |
CDK8 |
0.800 | 0.219 | 1 | 0.750 |
CDK1 |
0.799 | 0.201 | 1 | 0.754 |
CLK4 |
0.798 | 0.201 | -3 | 0.754 |
P90RSK |
0.798 | 0.130 | -3 | 0.778 |
MTOR |
0.797 | 0.055 | 1 | 0.740 |
ERK1 |
0.796 | 0.233 | 1 | 0.754 |
CLK1 |
0.796 | 0.198 | -3 | 0.731 |
HIPK3 |
0.796 | 0.276 | 1 | 0.785 |
ATR |
0.795 | 0.085 | 1 | 0.767 |
P38D |
0.795 | 0.256 | 1 | 0.694 |
SRPK2 |
0.795 | 0.150 | -3 | 0.679 |
DYRK1A |
0.794 | 0.239 | 1 | 0.788 |
PRPK |
0.794 | -0.003 | -1 | 0.782 |
PIM1 |
0.794 | 0.122 | -3 | 0.778 |
CDK17 |
0.794 | 0.214 | 1 | 0.688 |
CAMK1B |
0.794 | 0.056 | -3 | 0.836 |
P38G |
0.793 | 0.209 | 1 | 0.687 |
CAMLCK |
0.792 | 0.115 | -2 | 0.868 |
DYRK1B |
0.792 | 0.237 | 1 | 0.759 |
CDK14 |
0.792 | 0.219 | 1 | 0.751 |
GRK1 |
0.792 | 0.109 | -2 | 0.746 |
CDK5 |
0.791 | 0.184 | 1 | 0.783 |
JNK3 |
0.791 | 0.194 | 1 | 0.751 |
DAPK2 |
0.791 | 0.119 | -3 | 0.846 |
CHAK2 |
0.791 | 0.096 | -1 | 0.776 |
CDK13 |
0.791 | 0.176 | 1 | 0.746 |
CDK3 |
0.791 | 0.178 | 1 | 0.708 |
CDK10 |
0.790 | 0.208 | 1 | 0.742 |
RSK4 |
0.790 | 0.142 | -3 | 0.752 |
PKACB |
0.790 | 0.170 | -2 | 0.739 |
DYRK3 |
0.790 | 0.221 | 1 | 0.805 |
MAPKAPK2 |
0.790 | 0.128 | -3 | 0.741 |
RSK3 |
0.789 | 0.097 | -3 | 0.760 |
MAPKAPK3 |
0.789 | 0.122 | -3 | 0.779 |
NDR1 |
0.789 | 0.073 | -3 | 0.823 |
SRPK3 |
0.789 | 0.113 | -3 | 0.721 |
CDK12 |
0.788 | 0.180 | 1 | 0.724 |
PKACG |
0.786 | 0.098 | -2 | 0.788 |
NIK |
0.786 | 0.056 | -3 | 0.847 |
RAF1 |
0.786 | -0.050 | 1 | 0.719 |
WNK1 |
0.786 | 0.014 | -2 | 0.896 |
CAMK2A |
0.785 | 0.086 | 2 | 0.709 |
RIPK3 |
0.785 | -0.024 | 3 | 0.579 |
CDK16 |
0.784 | 0.203 | 1 | 0.702 |
PAK1 |
0.784 | 0.103 | -2 | 0.843 |
BMPR2 |
0.784 | -0.060 | -2 | 0.830 |
MSK1 |
0.784 | 0.114 | -3 | 0.748 |
CDK9 |
0.784 | 0.163 | 1 | 0.751 |
NUAK2 |
0.783 | 0.007 | -3 | 0.825 |
CAMK2D |
0.783 | 0.050 | -3 | 0.827 |
GRK5 |
0.782 | -0.023 | -3 | 0.820 |
IKKB |
0.782 | -0.053 | -2 | 0.683 |
GSK3A |
0.782 | 0.117 | 4 | 0.485 |
BUB1 |
0.782 | 0.341 | -5 | 0.761 |
P70S6KB |
0.782 | 0.063 | -3 | 0.779 |
TBK1 |
0.782 | -0.029 | 1 | 0.600 |
MLK2 |
0.782 | 0.114 | 2 | 0.733 |
GRK7 |
0.782 | 0.094 | 1 | 0.719 |
AURB |
0.781 | 0.120 | -2 | 0.722 |
MOK |
0.781 | 0.252 | 1 | 0.849 |
LATS1 |
0.781 | 0.123 | -3 | 0.863 |
BMPR1B |
0.781 | 0.082 | 1 | 0.763 |
PRKX |
0.781 | 0.141 | -3 | 0.679 |
PKN3 |
0.781 | 0.015 | -3 | 0.814 |
PKCD |
0.781 | 0.074 | 2 | 0.690 |
PKG2 |
0.780 | 0.127 | -2 | 0.739 |
PDHK4 |
0.780 | -0.198 | 1 | 0.754 |
LATS2 |
0.780 | 0.048 | -5 | 0.668 |
AMPKA1 |
0.780 | 0.016 | -3 | 0.839 |
PKN2 |
0.780 | 0.014 | -3 | 0.812 |
MNK2 |
0.780 | 0.106 | -2 | 0.828 |
GCN2 |
0.779 | -0.072 | 2 | 0.711 |
PAK3 |
0.779 | 0.080 | -2 | 0.828 |
PRP4 |
0.779 | 0.170 | -3 | 0.732 |
ERK2 |
0.778 | 0.152 | 1 | 0.776 |
PASK |
0.778 | 0.159 | -3 | 0.856 |
MNK1 |
0.778 | 0.109 | -2 | 0.827 |
IKKE |
0.778 | -0.055 | 1 | 0.592 |
PKCA |
0.778 | 0.089 | 2 | 0.640 |
AKT2 |
0.778 | 0.111 | -3 | 0.686 |
PRKD3 |
0.778 | 0.101 | -3 | 0.739 |
MPSK1 |
0.778 | 0.222 | 1 | 0.730 |
NEK6 |
0.777 | 0.003 | -2 | 0.801 |
AMPKA2 |
0.777 | 0.035 | -3 | 0.809 |
TSSK1 |
0.777 | 0.040 | -3 | 0.863 |
MYLK4 |
0.777 | 0.068 | -2 | 0.813 |
CAMK2G |
0.777 | -0.125 | 2 | 0.708 |
DSTYK |
0.777 | -0.099 | 2 | 0.797 |
TSSK2 |
0.776 | 0.007 | -5 | 0.791 |
MST4 |
0.776 | -0.036 | 2 | 0.761 |
TGFBR2 |
0.776 | -0.019 | -2 | 0.726 |
MLK3 |
0.776 | 0.047 | 2 | 0.658 |
HUNK |
0.776 | -0.098 | 2 | 0.766 |
PIM2 |
0.776 | 0.106 | -3 | 0.737 |
GSK3B |
0.776 | 0.067 | 4 | 0.482 |
MASTL |
0.775 | -0.082 | -2 | 0.782 |
MSK2 |
0.775 | 0.051 | -3 | 0.748 |
MARK4 |
0.775 | -0.047 | 4 | 0.656 |
PAK6 |
0.775 | 0.114 | -2 | 0.750 |
JNK1 |
0.775 | 0.163 | 1 | 0.725 |
CAMK2B |
0.775 | 0.018 | 2 | 0.680 |
ULK2 |
0.774 | -0.121 | 2 | 0.687 |
PKCB |
0.774 | 0.047 | 2 | 0.644 |
MLK1 |
0.774 | -0.104 | 2 | 0.725 |
IKKA |
0.773 | 0.002 | -2 | 0.669 |
DLK |
0.773 | -0.065 | 1 | 0.733 |
TGFBR1 |
0.773 | 0.024 | -2 | 0.728 |
PKCG |
0.773 | 0.041 | 2 | 0.655 |
PDHK1 |
0.773 | -0.170 | 1 | 0.720 |
GRK6 |
0.773 | -0.078 | 1 | 0.756 |
SGK3 |
0.772 | 0.089 | -3 | 0.751 |
ALK4 |
0.772 | 0.003 | -2 | 0.758 |
SMG1 |
0.771 | 0.015 | 1 | 0.724 |
RIPK1 |
0.771 | -0.103 | 1 | 0.711 |
PAK2 |
0.770 | 0.049 | -2 | 0.820 |
PKCZ |
0.770 | 0.044 | 2 | 0.685 |
VRK2 |
0.770 | 0.003 | 1 | 0.795 |
PKACA |
0.770 | 0.120 | -2 | 0.696 |
IRE1 |
0.769 | -0.047 | 1 | 0.706 |
CAMK4 |
0.769 | -0.020 | -3 | 0.796 |
AURA |
0.768 | 0.070 | -2 | 0.692 |
CDK2 |
0.768 | 0.054 | 1 | 0.803 |
MELK |
0.768 | 0.008 | -3 | 0.790 |
NEK9 |
0.767 | -0.106 | 2 | 0.732 |
PKR |
0.766 | -0.034 | 1 | 0.742 |
QSK |
0.766 | -0.009 | 4 | 0.636 |
DCAMKL1 |
0.766 | 0.044 | -3 | 0.776 |
DRAK1 |
0.766 | -0.004 | 1 | 0.713 |
NIM1 |
0.766 | -0.084 | 3 | 0.603 |
DNAPK |
0.766 | 0.007 | 1 | 0.633 |
ERK7 |
0.765 | 0.078 | 2 | 0.490 |
ANKRD3 |
0.765 | -0.138 | 1 | 0.745 |
NEK7 |
0.765 | -0.182 | -3 | 0.807 |
PHKG1 |
0.765 | 0.006 | -3 | 0.812 |
ATM |
0.764 | -0.053 | 1 | 0.706 |
MEK1 |
0.764 | -0.105 | 2 | 0.771 |
CDK6 |
0.764 | 0.152 | 1 | 0.730 |
TLK2 |
0.764 | 0.023 | 1 | 0.688 |
GRK4 |
0.763 | -0.109 | -2 | 0.771 |
YSK4 |
0.763 | -0.041 | 1 | 0.650 |
ULK1 |
0.763 | -0.144 | -3 | 0.783 |
ACVR2B |
0.763 | -0.008 | -2 | 0.714 |
WNK3 |
0.763 | -0.229 | 1 | 0.697 |
PKCH |
0.762 | -0.012 | 2 | 0.630 |
MST3 |
0.762 | 0.016 | 2 | 0.771 |
BCKDK |
0.762 | -0.157 | -1 | 0.666 |
LKB1 |
0.761 | 0.177 | -3 | 0.803 |
CDK4 |
0.761 | 0.153 | 1 | 0.717 |
CHK1 |
0.761 | 0.019 | -3 | 0.813 |
MLK4 |
0.760 | -0.054 | 2 | 0.640 |
TTBK2 |
0.760 | -0.148 | 2 | 0.618 |
CHAK1 |
0.760 | -0.082 | 2 | 0.710 |
BRSK1 |
0.760 | -0.030 | -3 | 0.776 |
ACVR2A |
0.760 | -0.031 | -2 | 0.703 |
ALK2 |
0.759 | -0.043 | -2 | 0.737 |
MARK3 |
0.759 | -0.036 | 4 | 0.593 |
AKT1 |
0.759 | 0.082 | -3 | 0.704 |
IRE2 |
0.759 | -0.058 | 2 | 0.646 |
NEK2 |
0.759 | -0.048 | 2 | 0.719 |
DAPK3 |
0.759 | 0.070 | -3 | 0.787 |
SMMLCK |
0.759 | 0.021 | -3 | 0.796 |
FAM20C |
0.759 | -0.046 | 2 | 0.524 |
GRK2 |
0.759 | -0.034 | -2 | 0.668 |
AKT3 |
0.758 | 0.124 | -3 | 0.637 |
CK1E |
0.758 | 0.005 | -3 | 0.550 |
PLK1 |
0.758 | -0.114 | -2 | 0.724 |
NUAK1 |
0.758 | -0.047 | -3 | 0.770 |
CAMK1G |
0.757 | -0.021 | -3 | 0.745 |
NEK5 |
0.757 | 0.017 | 1 | 0.728 |
GAK |
0.757 | 0.027 | 1 | 0.795 |
QIK |
0.757 | -0.120 | -3 | 0.809 |
ROCK2 |
0.756 | 0.134 | -3 | 0.774 |
BRSK2 |
0.756 | -0.056 | -3 | 0.794 |
MAPKAPK5 |
0.755 | -0.027 | -3 | 0.712 |
DAPK1 |
0.755 | 0.059 | -3 | 0.770 |
SIK |
0.755 | -0.040 | -3 | 0.746 |
PKCE |
0.754 | 0.039 | 2 | 0.644 |
PDHK3_TYR |
0.754 | 0.258 | 4 | 0.736 |
CK1D |
0.754 | 0.023 | -3 | 0.504 |
PAK4 |
0.754 | 0.083 | -2 | 0.713 |
DCAMKL2 |
0.754 | -0.015 | -3 | 0.791 |
SSTK |
0.754 | -0.003 | 4 | 0.623 |
MEK5 |
0.753 | -0.152 | 2 | 0.739 |
PAK5 |
0.753 | 0.069 | -2 | 0.703 |
SGK1 |
0.753 | 0.086 | -3 | 0.613 |
GCK |
0.753 | 0.067 | 1 | 0.693 |
BMPR1A |
0.753 | -0.014 | 1 | 0.726 |
WNK4 |
0.753 | -0.087 | -2 | 0.887 |
PBK |
0.752 | 0.135 | 1 | 0.730 |
TAO3 |
0.752 | -0.018 | 1 | 0.687 |
IRAK4 |
0.752 | -0.060 | 1 | 0.696 |
CK1A2 |
0.752 | 0.007 | -3 | 0.502 |
CAMK1D |
0.751 | 0.030 | -3 | 0.671 |
PERK |
0.751 | -0.072 | -2 | 0.758 |
PKCT |
0.751 | 0.003 | 2 | 0.631 |
P70S6K |
0.751 | 0.019 | -3 | 0.695 |
DMPK1 |
0.750 | 0.117 | -3 | 0.740 |
PLK4 |
0.750 | -0.088 | 2 | 0.570 |
PINK1 |
0.750 | -0.079 | 1 | 0.785 |
MEKK2 |
0.750 | -0.111 | 2 | 0.707 |
MRCKB |
0.749 | 0.082 | -3 | 0.719 |
SBK |
0.749 | 0.095 | -3 | 0.577 |
PKCI |
0.749 | -0.002 | 2 | 0.654 |
MARK2 |
0.749 | -0.096 | 4 | 0.557 |
SNRK |
0.749 | -0.136 | 2 | 0.609 |
CAMKK2 |
0.749 | 0.042 | -2 | 0.710 |
PLK3 |
0.749 | -0.130 | 2 | 0.691 |
PDK1 |
0.748 | -0.015 | 1 | 0.678 |
BRAF |
0.748 | -0.102 | -4 | 0.764 |
LIMK2_TYR |
0.748 | 0.249 | -3 | 0.865 |
MRCKA |
0.747 | 0.067 | -3 | 0.733 |
NEK11 |
0.747 | -0.094 | 1 | 0.672 |
ZAK |
0.746 | -0.138 | 1 | 0.659 |
PDHK4_TYR |
0.746 | 0.143 | 2 | 0.804 |
MEKK3 |
0.746 | -0.204 | 1 | 0.699 |
TESK1_TYR |
0.746 | 0.186 | 3 | 0.722 |
MEKK1 |
0.746 | -0.152 | 1 | 0.686 |
MAP3K15 |
0.746 | 0.014 | 1 | 0.647 |
TLK1 |
0.746 | -0.095 | -2 | 0.762 |
HPK1 |
0.746 | 0.014 | 1 | 0.674 |
MEKK6 |
0.746 | -0.014 | 1 | 0.706 |
TNIK |
0.745 | 0.043 | 3 | 0.701 |
GRK3 |
0.745 | -0.042 | -2 | 0.624 |
CAMKK1 |
0.745 | -0.064 | -2 | 0.701 |
MAP2K4_TYR |
0.745 | 0.162 | -1 | 0.779 |
KHS1 |
0.744 | 0.063 | 1 | 0.657 |
MARK1 |
0.744 | -0.108 | 4 | 0.602 |
CHK2 |
0.744 | 0.031 | -3 | 0.630 |
LOK |
0.744 | 0.053 | -2 | 0.754 |
CRIK |
0.743 | 0.101 | -3 | 0.714 |
HRI |
0.743 | -0.191 | -2 | 0.789 |
MAP2K6_TYR |
0.742 | 0.081 | -1 | 0.776 |
PKMYT1_TYR |
0.742 | 0.079 | 3 | 0.702 |
CK1G1 |
0.742 | -0.034 | -3 | 0.533 |
TNK2 |
0.741 | 0.167 | 3 | 0.635 |
CAMK1A |
0.741 | 0.044 | -3 | 0.647 |
LRRK2 |
0.741 | -0.065 | 2 | 0.751 |
EEF2K |
0.741 | -0.071 | 3 | 0.628 |
CK2A2 |
0.741 | -0.043 | 1 | 0.677 |
NEK8 |
0.741 | -0.115 | 2 | 0.725 |
NEK4 |
0.741 | -0.042 | 1 | 0.669 |
TAO2 |
0.741 | -0.100 | 2 | 0.746 |
EPHB4 |
0.741 | 0.146 | -1 | 0.731 |
NEK1 |
0.741 | 0.012 | 1 | 0.690 |
KHS2 |
0.740 | 0.033 | 1 | 0.675 |
HGK |
0.740 | -0.022 | 3 | 0.697 |
HASPIN |
0.739 | 0.085 | -1 | 0.741 |
SLK |
0.738 | 0.023 | -2 | 0.689 |
TAK1 |
0.738 | -0.081 | 1 | 0.694 |
PKN1 |
0.738 | -0.006 | -3 | 0.713 |
VRK1 |
0.738 | -0.101 | 2 | 0.753 |
ABL2 |
0.737 | 0.192 | -1 | 0.702 |
PHKG2 |
0.736 | -0.094 | -3 | 0.769 |
TXK |
0.736 | 0.136 | 1 | 0.790 |
EPHA6 |
0.736 | 0.061 | -1 | 0.749 |
BMPR2_TYR |
0.736 | -0.002 | -1 | 0.767 |
PDHK1_TYR |
0.736 | 0.008 | -1 | 0.777 |
MINK |
0.736 | -0.075 | 1 | 0.665 |
ROCK1 |
0.735 | 0.072 | -3 | 0.731 |
CK2A1 |
0.735 | -0.038 | 1 | 0.661 |
MST2 |
0.735 | -0.088 | 1 | 0.693 |
MAP2K7_TYR |
0.735 | -0.060 | 2 | 0.775 |
ABL1 |
0.733 | 0.166 | -1 | 0.694 |
STK33 |
0.732 | -0.092 | 2 | 0.562 |
RET |
0.730 | 0.025 | 1 | 0.704 |
TTBK1 |
0.730 | -0.178 | 2 | 0.548 |
FGR |
0.730 | 0.053 | 1 | 0.799 |
MST1 |
0.730 | -0.074 | 1 | 0.668 |
BIKE |
0.729 | 0.049 | 1 | 0.706 |
TYRO3 |
0.729 | 0.017 | 3 | 0.643 |
PKG1 |
0.729 | 0.040 | -2 | 0.666 |
PLK2 |
0.729 | -0.085 | -3 | 0.710 |
IRAK1 |
0.728 | -0.259 | -1 | 0.676 |
YANK3 |
0.728 | -0.038 | 2 | 0.373 |
OSR1 |
0.727 | -0.002 | 2 | 0.717 |
PINK1_TYR |
0.727 | -0.165 | 1 | 0.757 |
EPHA4 |
0.727 | 0.036 | 2 | 0.720 |
LIMK1_TYR |
0.727 | -0.056 | 2 | 0.753 |
TNK1 |
0.727 | 0.102 | 3 | 0.640 |
MST1R |
0.727 | -0.014 | 3 | 0.676 |
YSK1 |
0.726 | -0.086 | 2 | 0.707 |
YES1 |
0.726 | -0.024 | -1 | 0.770 |
AAK1 |
0.726 | 0.104 | 1 | 0.632 |
CSF1R |
0.726 | 0.005 | 3 | 0.654 |
MYO3B |
0.725 | 0.003 | 2 | 0.730 |
MERTK |
0.725 | 0.049 | 3 | 0.648 |
EPHB3 |
0.725 | 0.052 | -1 | 0.712 |
MEK2 |
0.724 | -0.169 | 2 | 0.723 |
LCK |
0.724 | 0.041 | -1 | 0.740 |
DDR1 |
0.724 | -0.088 | 4 | 0.648 |
ROS1 |
0.724 | -0.044 | 3 | 0.598 |
ITK |
0.724 | 0.028 | -1 | 0.703 |
SRMS |
0.724 | 0.018 | 1 | 0.778 |
EPHB1 |
0.723 | 0.005 | 1 | 0.765 |
JAK2 |
0.723 | -0.016 | 1 | 0.694 |
BLK |
0.722 | 0.023 | -1 | 0.742 |
ASK1 |
0.722 | -0.043 | 1 | 0.631 |
PTK2B |
0.722 | 0.097 | -1 | 0.688 |
BMX |
0.722 | 0.016 | -1 | 0.659 |
EPHB2 |
0.720 | 0.018 | -1 | 0.700 |
CK1A |
0.720 | -0.003 | -3 | 0.414 |
TTK |
0.720 | -0.081 | -2 | 0.756 |
HCK |
0.720 | -0.040 | -1 | 0.738 |
FER |
0.720 | -0.082 | 1 | 0.800 |
MET |
0.719 | 0.012 | 3 | 0.670 |
DDR2 |
0.718 | 0.031 | 3 | 0.573 |
FYN |
0.718 | 0.010 | -1 | 0.736 |
AXL |
0.718 | -0.015 | 3 | 0.635 |
KDR |
0.717 | -0.040 | 3 | 0.608 |
EPHA7 |
0.716 | 0.006 | 2 | 0.709 |
JAK3 |
0.716 | -0.097 | 1 | 0.687 |
KIT |
0.716 | -0.057 | 3 | 0.659 |
TYK2 |
0.716 | -0.181 | 1 | 0.693 |
NEK3 |
0.716 | -0.102 | 1 | 0.640 |
TNNI3K_TYR |
0.715 | 0.013 | 1 | 0.721 |
INSRR |
0.715 | -0.124 | 3 | 0.584 |
FGFR2 |
0.714 | -0.102 | 3 | 0.643 |
ALPHAK3 |
0.713 | -0.085 | -1 | 0.681 |
EPHA1 |
0.713 | 0.005 | 3 | 0.648 |
RIPK2 |
0.713 | -0.269 | 1 | 0.597 |
TEK |
0.713 | -0.079 | 3 | 0.584 |
EPHA3 |
0.713 | -0.029 | 2 | 0.684 |
JAK1 |
0.712 | -0.031 | 1 | 0.627 |
MYO3A |
0.711 | -0.101 | 1 | 0.660 |
TEC |
0.711 | -0.055 | -1 | 0.658 |
NEK10_TYR |
0.710 | -0.040 | 1 | 0.563 |
PTK2 |
0.708 | 0.031 | -1 | 0.684 |
LTK |
0.708 | -0.077 | 3 | 0.592 |
TAO1 |
0.708 | -0.101 | 1 | 0.594 |
FGFR1 |
0.708 | -0.114 | 3 | 0.611 |
WEE1_TYR |
0.707 | -0.096 | -1 | 0.675 |
PDGFRB |
0.707 | -0.149 | 3 | 0.648 |
ALK |
0.707 | -0.100 | 3 | 0.564 |
EPHA5 |
0.706 | -0.021 | 2 | 0.700 |
LYN |
0.705 | -0.065 | 3 | 0.576 |
SRC |
0.704 | -0.055 | -1 | 0.729 |
EPHA8 |
0.704 | -0.031 | -1 | 0.699 |
FGFR3 |
0.704 | -0.119 | 3 | 0.616 |
FLT1 |
0.704 | -0.087 | -1 | 0.696 |
FRK |
0.704 | -0.076 | -1 | 0.731 |
FLT3 |
0.703 | -0.177 | 3 | 0.648 |
PTK6 |
0.702 | -0.122 | -1 | 0.646 |
NTRK3 |
0.702 | -0.058 | -1 | 0.671 |
BTK |
0.702 | -0.169 | -1 | 0.678 |
PDGFRA |
0.701 | -0.157 | 3 | 0.648 |
NTRK1 |
0.701 | -0.151 | -1 | 0.704 |
MATK |
0.700 | -0.068 | -1 | 0.630 |
ERBB2 |
0.699 | -0.148 | 1 | 0.674 |
SYK |
0.699 | 0.000 | -1 | 0.669 |
EPHA2 |
0.698 | -0.016 | -1 | 0.661 |
CSK |
0.698 | -0.087 | 2 | 0.708 |
INSR |
0.697 | -0.161 | 3 | 0.571 |
ZAP70 |
0.697 | 0.071 | -1 | 0.618 |
STLK3 |
0.697 | -0.163 | 1 | 0.618 |
NTRK2 |
0.694 | -0.183 | 3 | 0.611 |
FLT4 |
0.694 | -0.191 | 3 | 0.599 |
EGFR |
0.693 | -0.094 | 1 | 0.601 |
FGFR4 |
0.692 | -0.085 | -1 | 0.657 |
YANK2 |
0.691 | -0.073 | 2 | 0.382 |
ERBB4 |
0.689 | -0.059 | 1 | 0.640 |
CK1G3 |
0.684 | -0.060 | -3 | 0.366 |
IGF1R |
0.684 | -0.154 | 3 | 0.522 |
MUSK |
0.683 | -0.110 | 1 | 0.594 |
FES |
0.679 | -0.114 | -1 | 0.630 |
CK1G2 |
0.676 | -0.056 | -3 | 0.453 |