Motif 17 (n=141)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NF01 | POM121B | S299 | ochoa | Putative nuclear envelope pore membrane protein POM 121B | Putative component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane (By similarity). {ECO:0000250}. |
| A6NJZ7 | RIMBP3C | S1322 | ochoa | RIMS-binding protein 3C (RIM-BP3.C) (RIMS-binding protein 3.3) (RIM-BP3.3) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A6NNM3 | RIMBP3B | S1322 | ochoa | RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| A8CG34 | POM121C | S692 | ochoa | Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| B2RTY4 | MYO9A | S1829 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| O00161 | SNAP23 | S136 | ochoa | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O15164 | TRIM24 | S209 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15195 | VILL | S723 | ochoa | Villin-like protein | Possible tumor suppressor. |
| O15372 | EIF3H | S183 | ochoa|psp | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43491 | EPB41L2 | S798 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43524 | FOXO3 | S43 | ochoa | Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) | Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882, PubMed:30513302). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Also acts as a key regulator of regulatory T-cells (Treg) differentiation by activating expression of FOXP3 (PubMed:30513302). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:30513302}. |
| O60658 | PDE8A | S20 | ochoa | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}. |
| O75151 | PHF2 | S625 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75381 | PEX14 | S44 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O94885 | SASH1 | S442 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94966 | USP19 | S244 | ochoa | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816). {ECO:0000250|UniProtKB:Q3UJD6, ECO:0000250|UniProtKB:Q6J1Y9, ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:24356957, ECO:0000269|PubMed:31127032, ECO:0000269|PubMed:33094816, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:38943386}. |
| O96019 | ACTL6A | S195 | psp | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P06401 | PGR | S213 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P07197 | NEFM | S633 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P14316 | IRF2 | S155 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
| P15336 | ATF2 | S112 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P19484 | TFEB | S81 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20810 | CAST | S243 | ochoa | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| P21980 | TGM2 | S68 | psp | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P30305 | CDC25B | S249 | ochoa|psp | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
| P30626 | SRI | S137 | ochoa | Sorcin (22 kDa protein) (CP-22) (CP22) (V19) | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
| P35568 | IRS1 | S1005 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| P35611 | ADD1 | S481 | ochoa|psp | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P38398 | BRCA1 | S1613 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P39880 | CUX1 | S1237 | ochoa|psp | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P42566 | EPS15 | S324 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P43358 | MAGEA4 | S99 | ochoa | Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen) | Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486). {ECO:0000269|PubMed:22842486}. |
| P49796 | RGS3 | S1044 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
| P52746 | ZNF142 | S1011 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P54198 | HIRA | S661 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P61371 | ISL1 | S221 | ochoa | Insulin gene enhancer protein ISL-1 (Islet-1) | DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). {ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374}. |
| P82094 | TMF1 | S77 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q05397 | PTK2 | S29 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q07869 | PPARA | S179 | psp | Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}. |
| Q09666 | AHNAK | S4993 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12765 | SCRN1 | S322 | ochoa | Secernin-1 | Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). {ECO:0000250}. |
| Q12888 | TP53BP1 | S265 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12986 | NFX1 | S95 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13029 | PRDM2 | S643 | ochoa | PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) | S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. {ECO:0000269|PubMed:14633678}. |
| Q14008 | CKAP5 | S816 | ochoa | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}. |
| Q14145 | KEAP1 | S104 | psp | Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15601839, PubMed:15983046, PubMed:37339955). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:19489739, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16006525, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17127771, ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:37339955}. |
| Q14244 | MAP7 | S235 | ochoa | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) | Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Q14258 | TRIM25 | S100 | ochoa | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, PubMed:33849980, PubMed:36045682). Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790, PubMed:23950712). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA (PubMed:28060952, PubMed:28202764). Also mediates the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability (PubMed:36067236). {ECO:0000250|UniProtKB:Q61510, ECO:0000269|PubMed:16352599, ECO:0000269|PubMed:17069755, ECO:0000269|PubMed:17392790, ECO:0000269|PubMed:22452784, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:29357390, ECO:0000269|PubMed:30193849, ECO:0000269|PubMed:31710640, ECO:0000269|PubMed:33849980, ECO:0000269|PubMed:36045682, ECO:0000269|PubMed:36067236}. |
| Q14739 | LBR | S160 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q15052 | ARHGEF6 | S225 | ochoa|psp | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Q3T8J9 | GON4L | S206 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q4KMZ1 | IQCC | S196 | ochoa | IQ domain-containing protein C | None |
| Q5JSZ5 | PRRC2B | S1358 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5JTC6 | AMER1 | S246 | ochoa | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5T0W9 | FAM83B | S976 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5THJ4 | VPS13D | S2079 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VV41 | ARHGEF16 | S77 | ochoa | Rho guanine nucleotide exchange factor 16 (Ephexin-4) | Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}. |
| Q5VV67 | PPRC1 | S1076 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5VZP5 | STYXL2 | S1054 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q6WKZ4 | RAB11FIP1 | S545 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6ZTU2 | EP400P1 | S347 | ochoa | Putative EP400-like protein (EP400 pseudogene 1) | None |
| Q7Z333 | SETX | S2612 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q86UB9 | TMEM135 | S198 | ochoa | Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) | Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}. |
| Q86VQ1 | GLCCI1 | S303 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86YA3 | ZGRF1 | S880 | ochoa | 5'-3' DNA helicase ZGRF1 (EC 5.6.2.3) (GRF-type zinc finger domain-containing protein 1) | 5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (PubMed:32640219, PubMed:34552057). Promotes HR by directly stimulating RAD51-mediated strand exchange activity (PubMed:32640219). Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment (PubMed:32640219). Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks (PubMed:34552057). Required for recruitment of replication protein RPA2 to DNA damage sites (PubMed:34552057). Promotes the initiation of the G2/M checkpoint but not its maintenance (PubMed:34552057). Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps (PubMed:32640219). {ECO:0000269|PubMed:32640219, ECO:0000269|PubMed:34552057}. |
| Q8IVF2 | AHNAK2 | S693 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S851 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1181 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S1676 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2006 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2336 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2666 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S2996 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S3986 | ochoa | Protein AHNAK2 | None |
| Q8IWC1 | MAP7D3 | S322 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWC1 | MAP7D3 | S441 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWC1 | MAP7D3 | S457 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IWC1 | MAP7D3 | S461 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IZL8 | PELP1 | S1043 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N1G0 | ZNF687 | S271 | ochoa | Zinc finger protein 687 | May be involved in transcriptional regulation. |
| Q8NC74 | RBBP8NL | S487 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8TBN0 | RAB3IL1 | S35 | ochoa | Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1) | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. {ECO:0000269|PubMed:20937701}. |
| Q8TDW5 | SYTL5 | S147 | ochoa | Synaptotagmin-like protein 5 | May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. |
| Q8WX93 | PALLD | S484 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WYL5 | SSH1 | S689 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q96A47 | ISL2 | S231 | ochoa | Insulin gene enhancer protein ISL-2 (Islet-2) | Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}. |
| Q96AG3 | SLC25A46 | S61 | ochoa | Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46) | Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269|PubMed:26168012, ECO:0000269|PubMed:27390132, ECO:0000269|PubMed:27543974}. |
| Q96C12 | ARMC5 | S510 | ochoa | Armadillo repeat-containing protein 5 | Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation (PubMed:35687106, PubMed:38225631, PubMed:39504960, PubMed:39667934). The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II (PubMed:39667934). The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2 (PubMed:35862218). Involved in fetal development, T-cell function and adrenal gland growth homeostasis (PubMed:24283224, PubMed:28676429). Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). {ECO:0000269|PubMed:24283224, ECO:0000269|PubMed:28676429, ECO:0000269|PubMed:35687106, ECO:0000269|PubMed:35862218, ECO:0000269|PubMed:38225631, ECO:0000269|PubMed:39504960, ECO:0000269|PubMed:39667934}. |
| Q96EV2 | RBM33 | S765 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96FZ2 | HMCES | S160 | ochoa | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235913, PubMed:31235915, PubMed:32307824, PubMed:32492421). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). The HMCES DNA-protein cross-link is then either reversed or degraded (PubMed:30554877, PubMed:36608669, PubMed:37519246, PubMed:37950866). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (PubMed:37519246, PubMed:37950866). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351, ECO:0000269|PubMed:32307824, ECO:0000269|PubMed:32492421, ECO:0000269|PubMed:35450882, ECO:0000269|PubMed:36608669, ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866}. |
| Q96HA1 | POM121 | S715 | ochoa | Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) | Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}. |
| Q96K83 | ZNF521 | S273 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96KR1 | ZFR | S553 | ochoa | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}. |
| Q96L91 | EP400 | S358 | ochoa | E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein) | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q96R06 | SPAG5 | S249 | ochoa|psp | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96T23 | RSF1 | S622 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q96T58 | SPEN | S2159 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S2366 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99958 | FOXC2 | S219 | ochoa|psp | Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14) | Transcriptional activator. {ECO:0000269|PubMed:9169153}. |
| Q9BRS8 | LARP6 | S396 | ochoa|psp | La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}. |
| Q9BUA3 | SPINDOC | S82 | ochoa | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271). {ECO:0000269|PubMed:33574238, ECO:0000269|PubMed:34737271}. |
| Q9BV36 | MLPH | S444 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BXB5 | OSBPL10 | S223 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BY89 | KIAA1671 | S981 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9H0X9 | OSBPL5 | S88 | ochoa | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}. |
| Q9H2F5 | EPC1 | S357 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q9H6Y5 | MAGIX | S272 | ochoa | PDZ domain-containing protein MAGIX | None |
| Q9H792 | PEAK1 | S572 | ochoa | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:20534451, PubMed:23105102, PubMed:35687021). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). {ECO:0000269|PubMed:20534451, ECO:0000269|PubMed:23105102, ECO:0000269|PubMed:23846654, ECO:0000269|PubMed:35687021}. |
| Q9H7M9 | VSIR | S264 | ochoa | V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) | Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}. |
| Q9HAU0 | PLEKHA5 | S1037 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9NP31 | SH2D2A | S43 | ochoa | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| Q9NQ66 | PLCB1 | S887 | psp | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier. {ECO:0000250|UniProtKB:Q9Z1B3, ECO:0000269|PubMed:9188725}. |
| Q9NQ92 | COPRS | S31 | ochoa | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}. |
| Q9NUJ3 | TCP11L1 | S300 | ochoa | T-complex protein 11-like protein 1 | None |
| Q9NVU7 | SDAD1 | S459 | ochoa | Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) | Required for 60S pre-ribosomal subunits export to the cytoplasm. {ECO:0000250}. |
| Q9NWS6 | FAM118A | S311 | ochoa | Protein FAM118A | None |
| Q9NYF5 | FAM13B | S501 | ochoa | Protein FAM13B (GAP-like protein N61) | None |
| Q9NYK6 | EURL | S205 | ochoa | Protein EURL homolog | Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway. {ECO:0000250|UniProtKB:Q9D7G4}. |
| Q9P1Y6 | PHRF1 | S867 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P266 | JCAD | S901 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UFD9 | RIMBP3 | S1322 | ochoa | RIMS-binding protein 3A (RIM-BP3.A) (RIMS-binding protein 3.1) (RIM-BP3.1) | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. {ECO:0000250|UniProtKB:Q3V0F0}. |
| Q9UKD1 | GMEB2 | S126 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9ULH7 | MRTFB | S863 | ochoa | Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2) | Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. {ECO:0000269|PubMed:14565952}. |
| Q9UM54 | MYO6 | S1155 | ochoa | Unconventional myosin-VI (Unconventional myosin-6) | Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}. |
| Q9UPP1 | PHF8 | S175 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPQ3 | AGAP1 | S521 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1) | GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
| Q9UQ35 | SRRM2 | S857 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y253 | POLH | S587 | psp | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:16357261, PubMed:24449906, PubMed:24553286, PubMed:38212351). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940). Targets POLI to replication foci (PubMed:12606586). {ECO:0000269|PubMed:10385124, ECO:0000269|PubMed:11376341, ECO:0000269|PubMed:11743006, ECO:0000269|PubMed:12606586, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:14734526, ECO:0000269|PubMed:16357261, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:38212351}. |
| Q9Y261 | FOXA2 | S436 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2Z0 | SUGT1 | S281 | ochoa|psp | Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog) | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Q9Y4G8 | RAPGEF2 | S1080 | ochoa | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. |
| Q9Y692 | GMEB1 | S129 | ochoa | Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9Y6X8 | ZHX2 | T207 | ochoa | Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2) | Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250|UniProtKB:Q8C0C0, ECO:0000269|PubMed:12741956}. |
| O43172 | PRPF4 | S298 | Sugiyama | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O15264 | MAPK13 | S278 | Sugiyama | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}. |
| P07942 | LAMB1 | S1237 | Sugiyama | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P43490 | NAMPT | S241 | Sugiyama | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| Q15303 | ERBB4 | S1263 | Sugiyama | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q12931 | TRAP1 | S361 | Sugiyama | Heat shock protein 75 kDa, mitochondrial (HSP 75) (Heat shock protein family C member 5) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}. |
| Q9NR20 | DYRK4 | S501 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) | Possible non-essential role in spermiogenesis. {ECO:0000250}. |
| Q9UM73 | ALK | S1437 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.000009 | 5.049 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.000197 | 3.705 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.000189 | 3.723 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.000821 | 3.086 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.000806 | 3.094 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.000628 | 3.202 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.000958 | 3.019 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 0.001275 | 2.894 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.001275 | 2.894 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.005765 | 2.239 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.003484 | 2.458 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.003484 | 2.458 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.003484 | 2.458 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.004538 | 2.343 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.005336 | 2.273 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.005525 | 2.258 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.005765 | 2.239 |
| R-HSA-9620244 | Long-term potentiation | 0.003816 | 2.418 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.005765 | 2.239 |
| R-HSA-9909396 | Circadian clock | 0.003842 | 2.415 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.005764 | 2.239 |
| R-HSA-8848021 | Signaling by PTK6 | 0.005764 | 2.239 |
| R-HSA-9700649 | Drug resistance of ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717319 | brigatinib-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717264 | ASP-3026-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717326 | crizotinib-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717323 | ceritinib-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717329 | lorlatinib-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717316 | alectinib-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 0.009887 | 2.005 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.009887 | 2.005 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 0.010011 | 2.000 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.010011 | 2.000 |
| R-HSA-201556 | Signaling by ALK | 0.011195 | 1.951 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.011076 | 1.956 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.011195 | 1.951 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.007003 | 2.155 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.009118 | 2.040 |
| R-HSA-68875 | Mitotic Prophase | 0.011333 | 1.946 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.012694 | 1.896 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.012694 | 1.896 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.014074 | 1.852 |
| R-HSA-8939211 | ESR-mediated signaling | 0.014913 | 1.826 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.019677 | 1.706 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.019677 | 1.706 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.019677 | 1.706 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.019677 | 1.706 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.019677 | 1.706 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.019677 | 1.706 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.019677 | 1.706 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.015653 | 1.805 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.017104 | 1.767 |
| R-HSA-4839726 | Chromatin organization | 0.018631 | 1.730 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.018970 | 1.722 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.020585 | 1.686 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.022355 | 1.651 |
| R-HSA-3214847 | HATs acetylate histones | 0.024749 | 1.606 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.026075 | 1.584 |
| R-HSA-9758941 | Gastrulation | 0.026368 | 1.579 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.030027 | 1.522 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.030921 | 1.510 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.034200 | 1.466 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.057884 | 1.237 |
| R-HSA-74713 | IRS activation | 0.067203 | 1.173 |
| R-HSA-112412 | SOS-mediated signalling | 0.094612 | 1.024 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.112438 | 0.949 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.129916 | 0.886 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.129916 | 0.886 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.129916 | 0.886 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.129916 | 0.886 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.138526 | 0.858 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.040851 | 1.389 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.147051 | 0.833 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.147051 | 0.833 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.050403 | 1.298 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.052905 | 1.277 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.052905 | 1.277 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 0.055450 | 1.256 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.172128 | 0.764 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.058038 | 1.236 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.058038 | 1.236 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.060667 | 1.217 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.180322 | 0.744 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.066044 | 1.180 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.188437 | 0.725 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.196471 | 0.707 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.077248 | 1.112 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.204427 | 0.689 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.080136 | 1.096 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.212304 | 0.673 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.212304 | 0.673 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.220103 | 0.657 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.220103 | 0.657 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.220103 | 0.657 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.220103 | 0.657 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.220103 | 0.657 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.042130 | 1.375 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.055098 | 1.259 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.265315 | 0.576 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.294000 | 0.532 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.214398 | 0.669 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.239470 | 0.621 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.204427 | 0.689 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.225302 | 0.647 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.172128 | 0.764 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.235473 | 0.628 |
| R-HSA-198203 | PI3K/AKT activation | 0.121220 | 0.916 |
| R-HSA-3000157 | Laminin interactions | 0.265315 | 0.576 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.279800 | 0.553 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.192763 | 0.715 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.057884 | 1.237 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.221662 | 0.654 |
| R-HSA-8849473 | PTK6 Expression | 0.094612 | 1.024 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.088999 | 1.051 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.050585 | 1.296 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.131306 | 0.882 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.129916 | 0.886 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.152522 | 0.817 |
| R-HSA-5693538 | Homology Directed Repair | 0.043553 | 1.361 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.182058 | 0.740 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.055450 | 1.256 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.188437 | 0.725 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.171449 | 0.766 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.058038 | 1.236 |
| R-HSA-190873 | Gap junction degradation | 0.112438 | 0.949 |
| R-HSA-4839744 | Signaling by APC mutants | 0.129916 | 0.886 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.138526 | 0.858 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.155493 | 0.808 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 0.180322 | 0.744 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.063336 | 1.198 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.071574 | 1.145 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.204427 | 0.689 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.098135 | 1.008 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.257965 | 0.588 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.257965 | 0.588 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.085940 | 1.066 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.307922 | 0.512 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.047945 | 1.319 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.092008 | 1.036 |
| R-HSA-74749 | Signal attenuation | 0.121220 | 0.916 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.083058 | 1.081 |
| R-HSA-8875878 | MET promotes cell motility | 0.074393 | 1.128 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.094612 | 1.024 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.112438 | 0.949 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.121220 | 0.916 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.060667 | 1.217 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.155493 | 0.808 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.189185 | 0.723 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.143740 | 0.842 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.080136 | 1.096 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.080136 | 1.096 |
| R-HSA-73893 | DNA Damage Bypass | 0.110703 | 0.956 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.129916 | 0.886 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.138526 | 0.858 |
| R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | 0.180322 | 0.744 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.143740 | 0.842 |
| R-HSA-191859 | snRNP Assembly | 0.143740 | 0.842 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.150576 | 0.822 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.138044 | 0.860 |
| R-HSA-9610379 | HCMV Late Events | 0.252671 | 0.597 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.107522 | 0.969 |
| R-HSA-9842663 | Signaling by LTK | 0.147051 | 0.833 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.265315 | 0.576 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.265315 | 0.576 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.272593 | 0.564 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.171449 | 0.766 |
| R-HSA-194138 | Signaling by VEGF | 0.163699 | 0.786 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.063336 | 1.198 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.188437 | 0.725 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.086013 | 1.065 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.235473 | 0.628 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.279800 | 0.553 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.058038 | 1.236 |
| R-HSA-182971 | EGFR downregulation | 0.307922 | 0.512 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.307922 | 0.512 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 0.112438 | 0.949 |
| R-HSA-425561 | Sodium/Calcium exchangers | 0.138526 | 0.858 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.080136 | 1.096 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.080136 | 1.096 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.083058 | 1.081 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.250542 | 0.601 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.059798 | 1.223 |
| R-HSA-429947 | Deadenylation of mRNA | 0.257965 | 0.588 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.307922 | 0.512 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.196349 | 0.707 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.073208 | 1.135 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.095061 | 1.022 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.147051 | 0.833 |
| R-HSA-9733709 | Cardiogenesis | 0.058038 | 1.236 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.212304 | 0.673 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.154019 | 0.812 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.142600 | 0.846 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.098135 | 1.008 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.218028 | 0.661 |
| R-HSA-68886 | M Phase | 0.108463 | 0.965 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.076429 | 1.117 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.163851 | 0.786 |
| R-HSA-171007 | p38MAPK events | 0.172128 | 0.764 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.172128 | 0.764 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.074393 | 1.128 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.077248 | 1.112 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.101237 | 0.995 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.189185 | 0.723 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 0.279800 | 0.553 |
| R-HSA-73894 | DNA Repair | 0.178706 | 0.748 |
| R-HSA-3214842 | HDMs demethylate histones | 0.038583 | 1.414 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.163851 | 0.786 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.196471 | 0.707 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.077248 | 1.112 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.272593 | 0.564 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.286935 | 0.542 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.307922 | 0.512 |
| R-HSA-177929 | Signaling by EGFR | 0.133616 | 0.874 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.244737 | 0.611 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.136972 | 0.863 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.305811 | 0.515 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.121220 | 0.916 |
| R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp... | 0.188437 | 0.725 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.133616 | 0.874 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 0.272593 | 0.564 |
| R-HSA-622312 | Inflammasomes | 0.286935 | 0.542 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.154019 | 0.812 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.156563 | 0.805 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.126881 | 0.897 |
| R-HSA-913531 | Interferon Signaling | 0.215101 | 0.667 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.213468 | 0.671 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.038583 | 1.414 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.172128 | 0.764 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.294000 | 0.532 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.294000 | 0.532 |
| R-HSA-6806834 | Signaling by MET | 0.058211 | 1.235 |
| R-HSA-1640170 | Cell Cycle | 0.060658 | 1.217 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.042385 | 1.373 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.300995 | 0.521 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.089073 | 1.050 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.160949 | 0.793 |
| R-HSA-2586552 | Signaling by Leptin | 0.121220 | 0.916 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.235473 | 0.628 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.230358 | 0.638 |
| R-HSA-162582 | Signal Transduction | 0.255014 | 0.593 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.196349 | 0.707 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.112438 | 0.949 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.163851 | 0.786 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.172128 | 0.764 |
| R-HSA-167044 | Signalling to RAS | 0.227826 | 0.642 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.175803 | 0.755 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.043553 | 1.361 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.157477 | 0.803 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.243045 | 0.614 |
| R-HSA-1266738 | Developmental Biology | 0.169452 | 0.771 |
| R-HSA-877300 | Interferon gamma signaling | 0.101086 | 0.995 |
| R-HSA-70171 | Glycolysis | 0.302162 | 0.520 |
| R-HSA-1181150 | Signaling by NODAL | 0.220103 | 0.657 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.220103 | 0.657 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.286935 | 0.542 |
| R-HSA-5620971 | Pyroptosis | 0.286935 | 0.542 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.294000 | 0.532 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.160387 | 0.795 |
| R-HSA-9707616 | Heme signaling | 0.154019 | 0.812 |
| R-HSA-5688426 | Deubiquitination | 0.140293 | 0.853 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.235473 | 0.628 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.214398 | 0.669 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.088923 | 1.051 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.243045 | 0.614 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.250542 | 0.601 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.309457 | 0.509 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.170931 | 0.767 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.210775 | 0.676 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.210775 | 0.676 |
| R-HSA-2262752 | Cellular responses to stress | 0.153046 | 0.815 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.192763 | 0.715 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.184103 | 0.735 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.063336 | 1.198 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.250542 | 0.601 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.272593 | 0.564 |
| R-HSA-166520 | Signaling by NTRKs | 0.228999 | 0.640 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.055450 | 1.256 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.205491 | 0.687 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.120391 | 0.919 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.074864 | 1.126 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.265315 | 0.576 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.250542 | 0.601 |
| R-HSA-75153 | Apoptotic execution phase | 0.101237 | 0.995 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.292068 | 0.535 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.082909 | 1.081 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.071464 | 1.146 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.243561 | 0.613 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.298509 | 0.525 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.265546 | 0.576 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.256117 | 0.592 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.103576 | 0.985 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.089186 | 1.050 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.096626 | 1.015 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.314780 | 0.502 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.321571 | 0.493 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.321571 | 0.493 |
| R-HSA-354192 | Integrin signaling | 0.321571 | 0.493 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.321571 | 0.493 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.321571 | 0.493 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.321571 | 0.493 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.321571 | 0.493 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.321571 | 0.493 |
| R-HSA-390522 | Striated Muscle Contraction | 0.328295 | 0.484 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.328295 | 0.484 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.328295 | 0.484 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.328295 | 0.484 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.328295 | 0.484 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.331242 | 0.480 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.331242 | 0.480 |
| R-HSA-211000 | Gene Silencing by RNA | 0.331242 | 0.480 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.334856 | 0.475 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.334953 | 0.475 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.334953 | 0.475 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.334953 | 0.475 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.341545 | 0.467 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.341545 | 0.467 |
| R-HSA-187687 | Signalling to ERKs | 0.341545 | 0.467 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.346175 | 0.461 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.348072 | 0.458 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.354535 | 0.450 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.354535 | 0.450 |
| R-HSA-112316 | Neuronal System | 0.358868 | 0.445 |
| R-HSA-9609690 | HCMV Early Events | 0.360391 | 0.443 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.360934 | 0.443 |
| R-HSA-9931953 | Biofilm formation | 0.360934 | 0.443 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.367099 | 0.435 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.373544 | 0.428 |
| R-HSA-70326 | Glucose metabolism | 0.374187 | 0.427 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.379756 | 0.420 |
| R-HSA-9607240 | FLT3 Signaling | 0.379756 | 0.420 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.385906 | 0.414 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.385906 | 0.414 |
| R-HSA-5357801 | Programmed Cell Death | 0.387259 | 0.412 |
| R-HSA-73886 | Chromosome Maintenance | 0.388263 | 0.411 |
| R-HSA-3371556 | Cellular response to heat stress | 0.388263 | 0.411 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.388263 | 0.411 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.391997 | 0.407 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 0.391997 | 0.407 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.395250 | 0.403 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.398730 | 0.399 |
| R-HSA-373752 | Netrin-1 signaling | 0.403997 | 0.394 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.403997 | 0.394 |
| R-HSA-190828 | Gap junction trafficking | 0.403997 | 0.394 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.409909 | 0.387 |
| R-HSA-774815 | Nucleosome assembly | 0.409909 | 0.387 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.409909 | 0.387 |
| R-HSA-69481 | G2/M Checkpoints | 0.412556 | 0.385 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.415762 | 0.381 |
| R-HSA-9675135 | Diseases of DNA repair | 0.415762 | 0.381 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.415762 | 0.381 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.415762 | 0.381 |
| R-HSA-68882 | Mitotic Anaphase | 0.416502 | 0.380 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.419140 | 0.378 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.421558 | 0.375 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.427297 | 0.369 |
| R-HSA-425410 | Metal ion SLC transporters | 0.427297 | 0.369 |
| R-HSA-1500931 | Cell-Cell communication | 0.428935 | 0.368 |
| R-HSA-9843745 | Adipogenesis | 0.429617 | 0.367 |
| R-HSA-8951664 | Neddylation | 0.429652 | 0.367 |
| R-HSA-9766229 | Degradation of CDH1 | 0.432979 | 0.364 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.432979 | 0.364 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.432998 | 0.364 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.437764 | 0.359 |
| R-HSA-109704 | PI3K Cascade | 0.438605 | 0.358 |
| R-HSA-912446 | Meiotic recombination | 0.444176 | 0.352 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.447884 | 0.349 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.449691 | 0.347 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.449691 | 0.347 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.449691 | 0.347 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.449691 | 0.347 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.455152 | 0.342 |
| R-HSA-1221632 | Meiotic synapsis | 0.455152 | 0.342 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.459655 | 0.338 |
| R-HSA-72649 | Translation initiation complex formation | 0.460560 | 0.337 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.471215 | 0.327 |
| R-HSA-5578775 | Ion homeostasis | 0.471215 | 0.327 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.472711 | 0.325 |
| R-HSA-112399 | IRS-mediated signalling | 0.476464 | 0.322 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.476464 | 0.322 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.476464 | 0.322 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.481661 | 0.317 |
| R-HSA-9033241 | Peroxisomal protein import | 0.486807 | 0.313 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.486807 | 0.313 |
| R-HSA-186712 | Regulation of beta-cell development | 0.486807 | 0.313 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.491902 | 0.308 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.491902 | 0.308 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.496947 | 0.304 |
| R-HSA-112043 | PLC beta mediated events | 0.496947 | 0.304 |
| R-HSA-450294 | MAP kinase activation | 0.496947 | 0.304 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.501942 | 0.299 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.501942 | 0.299 |
| R-HSA-9609646 | HCMV Infection | 0.503556 | 0.298 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.506888 | 0.295 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.506888 | 0.295 |
| R-HSA-73887 | Death Receptor Signaling | 0.510722 | 0.292 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.511785 | 0.291 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.511785 | 0.291 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.511785 | 0.291 |
| R-HSA-1989781 | PPARA activates gene expression | 0.513808 | 0.289 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.513808 | 0.289 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.516633 | 0.287 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.516633 | 0.287 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.519943 | 0.284 |
| R-HSA-162587 | HIV Life Cycle | 0.519943 | 0.284 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.521434 | 0.283 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.523091 | 0.281 |
| R-HSA-112040 | G-protein mediated events | 0.526187 | 0.279 |
| R-HSA-196807 | Nicotinate metabolism | 0.526187 | 0.279 |
| R-HSA-9830369 | Kidney development | 0.526187 | 0.279 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.530894 | 0.275 |
| R-HSA-5218859 | Regulated Necrosis | 0.530894 | 0.275 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.531295 | 0.275 |
| R-HSA-109581 | Apoptosis | 0.535054 | 0.272 |
| R-HSA-448424 | Interleukin-17 signaling | 0.540168 | 0.267 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.540168 | 0.267 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.544736 | 0.264 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.544736 | 0.264 |
| R-HSA-3000178 | ECM proteoglycans | 0.544736 | 0.264 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.544736 | 0.264 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.549260 | 0.260 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.549260 | 0.260 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.549260 | 0.260 |
| R-HSA-5619102 | SLC transporter disorders | 0.549839 | 0.260 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.553738 | 0.257 |
| R-HSA-4086398 | Ca2+ pathway | 0.553738 | 0.257 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.553738 | 0.257 |
| R-HSA-72306 | tRNA processing | 0.561429 | 0.251 |
| R-HSA-380287 | Centrosome maturation | 0.562564 | 0.250 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.562564 | 0.250 |
| R-HSA-8852135 | Protein ubiquitination | 0.562564 | 0.250 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.562564 | 0.250 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.566911 | 0.246 |
| R-HSA-5689603 | UCH proteinases | 0.566911 | 0.246 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.569982 | 0.244 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.569982 | 0.244 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.569982 | 0.244 |
| R-HSA-446728 | Cell junction organization | 0.570040 | 0.244 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.575477 | 0.240 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.583875 | 0.234 |
| R-HSA-9833482 | PKR-mediated signaling | 0.583875 | 0.234 |
| R-HSA-168255 | Influenza Infection | 0.586727 | 0.232 |
| R-HSA-2559583 | Cellular Senescence | 0.589471 | 0.230 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.596163 | 0.225 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.600178 | 0.222 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.600178 | 0.222 |
| R-HSA-1500620 | Meiosis | 0.604154 | 0.219 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.604154 | 0.219 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.604154 | 0.219 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.604154 | 0.219 |
| R-HSA-212436 | Generic Transcription Pathway | 0.605453 | 0.218 |
| R-HSA-69275 | G2/M Transition | 0.605651 | 0.218 |
| R-HSA-1483257 | Phospholipid metabolism | 0.607656 | 0.216 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.608090 | 0.216 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.608090 | 0.216 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.608090 | 0.216 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.610937 | 0.214 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.611988 | 0.213 |
| R-HSA-195721 | Signaling by WNT | 0.614065 | 0.212 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.619668 | 0.208 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.621348 | 0.207 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.623451 | 0.205 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.626473 | 0.203 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.627197 | 0.203 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.630905 | 0.200 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.631544 | 0.200 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.638213 | 0.195 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.638213 | 0.195 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.641527 | 0.193 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.648875 | 0.188 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.648906 | 0.188 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.652400 | 0.185 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.653702 | 0.185 |
| R-HSA-72172 | mRNA Splicing | 0.653707 | 0.185 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.655859 | 0.183 |
| R-HSA-199991 | Membrane Trafficking | 0.656906 | 0.182 |
| R-HSA-157579 | Telomere Maintenance | 0.659284 | 0.181 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.659284 | 0.181 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.662676 | 0.179 |
| R-HSA-422356 | Regulation of insulin secretion | 0.662676 | 0.179 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.662676 | 0.179 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.662676 | 0.179 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.662676 | 0.179 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.666033 | 0.177 |
| R-HSA-8957322 | Metabolism of steroids | 0.666650 | 0.176 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.669358 | 0.174 |
| R-HSA-397014 | Muscle contraction | 0.672510 | 0.172 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.675909 | 0.170 |
| R-HSA-1483255 | PI Metabolism | 0.675909 | 0.170 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.682331 | 0.166 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.682331 | 0.166 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.682331 | 0.166 |
| R-HSA-111885 | Opioid Signalling | 0.682331 | 0.166 |
| R-HSA-9833110 | RSV-host interactions | 0.685494 | 0.164 |
| R-HSA-418990 | Adherens junctions interactions | 0.686067 | 0.164 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.688626 | 0.162 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.688626 | 0.162 |
| R-HSA-418346 | Platelet homeostasis | 0.691727 | 0.160 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.691727 | 0.160 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.697837 | 0.156 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.697837 | 0.156 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.697837 | 0.156 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.697837 | 0.156 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.697837 | 0.156 |
| R-HSA-74160 | Gene expression (Transcription) | 0.699939 | 0.155 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.700847 | 0.154 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.700847 | 0.154 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.703827 | 0.153 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.703827 | 0.153 |
| R-HSA-162906 | HIV Infection | 0.705542 | 0.151 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.712153 | 0.147 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.712591 | 0.147 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.715455 | 0.145 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.718291 | 0.144 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.721098 | 0.142 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.726629 | 0.139 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.726629 | 0.139 |
| R-HSA-373760 | L1CAM interactions | 0.726629 | 0.139 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.729354 | 0.137 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.729354 | 0.137 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.734723 | 0.134 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.734723 | 0.134 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.734723 | 0.134 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.736047 | 0.133 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.739986 | 0.131 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.742578 | 0.129 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.742578 | 0.129 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.745248 | 0.128 |
| R-HSA-421270 | Cell-cell junction organization | 0.752620 | 0.123 |
| R-HSA-114608 | Platelet degranulation | 0.757602 | 0.121 |
| R-HSA-1474165 | Reproduction | 0.767131 | 0.115 |
| R-HSA-5576891 | Cardiac conduction | 0.769454 | 0.114 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.774032 | 0.111 |
| R-HSA-416476 | G alpha (q) signalling events | 0.775328 | 0.111 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.782918 | 0.106 |
| R-HSA-163685 | Integration of energy metabolism | 0.782918 | 0.106 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.785085 | 0.105 |
| R-HSA-6807070 | PTEN Regulation | 0.789354 | 0.103 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.791457 | 0.102 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.791457 | 0.102 |
| R-HSA-9664407 | Parasite infection | 0.791457 | 0.102 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.791546 | 0.102 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.793540 | 0.100 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.799663 | 0.097 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.802279 | 0.096 |
| R-HSA-9658195 | Leishmania infection | 0.802279 | 0.096 |
| R-HSA-69242 | S Phase | 0.809469 | 0.092 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.809469 | 0.092 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.813257 | 0.090 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.816970 | 0.088 |
| R-HSA-9609507 | Protein localization | 0.818799 | 0.087 |
| R-HSA-9679506 | SARS-CoV Infections | 0.827369 | 0.082 |
| R-HSA-9711097 | Cellular response to starvation | 0.827674 | 0.082 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.831102 | 0.080 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.836624 | 0.077 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.837756 | 0.077 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.848780 | 0.071 |
| R-HSA-418555 | G alpha (s) signalling events | 0.850293 | 0.070 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.854741 | 0.068 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.856195 | 0.067 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.856195 | 0.067 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.856978 | 0.067 |
| R-HSA-8953854 | Metabolism of RNA | 0.857914 | 0.067 |
| R-HSA-611105 | Respiratory electron transport | 0.860469 | 0.065 |
| R-HSA-597592 | Post-translational protein modification | 0.862790 | 0.064 |
| R-HSA-1474244 | Extracellular matrix organization | 0.865695 | 0.063 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.867315 | 0.062 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.873826 | 0.059 |
| R-HSA-983712 | Ion channel transport | 0.875090 | 0.058 |
| R-HSA-5617833 | Cilium Assembly | 0.876341 | 0.057 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.877579 | 0.057 |
| R-HSA-68877 | Mitotic Prometaphase | 0.880020 | 0.056 |
| R-HSA-449147 | Signaling by Interleukins | 0.887404 | 0.052 |
| R-HSA-1643685 | Disease | 0.889748 | 0.051 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.891515 | 0.050 |
| R-HSA-9640148 | Infection with Enterobacteria | 0.891515 | 0.050 |
| R-HSA-388396 | GPCR downstream signalling | 0.900299 | 0.046 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.912202 | 0.040 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.914832 | 0.039 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.917079 | 0.038 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.918201 | 0.037 |
| R-HSA-72312 | rRNA processing | 0.919836 | 0.036 |
| R-HSA-422475 | Axon guidance | 0.922629 | 0.035 |
| R-HSA-418594 | G alpha (i) signalling events | 0.927890 | 0.033 |
| R-HSA-372790 | Signaling by GPCR | 0.940041 | 0.027 |
| R-HSA-9675108 | Nervous system development | 0.941003 | 0.026 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.951645 | 0.022 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.951703 | 0.021 |
| R-HSA-109582 | Hemostasis | 0.961138 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.973423 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.978967 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.985126 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 0.987613 | 0.005 |
| R-HSA-72766 | Translation | 0.989272 | 0.005 |
| R-HSA-9824446 | Viral Infection Pathways | 0.990535 | 0.004 |
| R-HSA-5663205 | Infectious disease | 0.990701 | 0.004 |
| R-HSA-6798695 | Neutrophil degranulation | 0.991944 | 0.004 |
| R-HSA-168249 | Innate Immune System | 0.993622 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.994254 | 0.003 |
| R-HSA-168256 | Immune System | 0.998498 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.999601 | 0.000 |
| R-HSA-1280218 | Adaptive Immune System | 0.999787 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.823 | 0.668 | 1 | 0.904 |
CDK18 |
0.822 | 0.678 | 1 | 0.892 |
CDK8 |
0.820 | 0.667 | 1 | 0.881 |
KIS |
0.817 | 0.599 | 1 | 0.867 |
CDK17 |
0.817 | 0.676 | 1 | 0.911 |
P38G |
0.817 | 0.696 | 1 | 0.921 |
CDK3 |
0.814 | 0.577 | 1 | 0.904 |
CDK7 |
0.813 | 0.657 | 1 | 0.876 |
HIPK2 |
0.812 | 0.605 | 1 | 0.873 |
ERK1 |
0.812 | 0.670 | 1 | 0.886 |
JNK2 |
0.811 | 0.698 | 1 | 0.915 |
P38D |
0.810 | 0.683 | 1 | 0.920 |
CDK16 |
0.810 | 0.647 | 1 | 0.900 |
P38B |
0.810 | 0.685 | 1 | 0.871 |
CDK5 |
0.809 | 0.631 | 1 | 0.849 |
CDK1 |
0.806 | 0.626 | 1 | 0.878 |
JNK3 |
0.805 | 0.685 | 1 | 0.891 |
CDK13 |
0.803 | 0.634 | 1 | 0.891 |
DYRK2 |
0.802 | 0.585 | 1 | 0.820 |
CDK12 |
0.800 | 0.632 | 1 | 0.908 |
P38A |
0.800 | 0.658 | 1 | 0.825 |
HIPK4 |
0.798 | 0.406 | 1 | 0.640 |
CLK3 |
0.797 | 0.403 | 1 | 0.622 |
CDK14 |
0.796 | 0.626 | 1 | 0.878 |
DYRK4 |
0.794 | 0.580 | 1 | 0.890 |
CDK9 |
0.794 | 0.616 | 1 | 0.888 |
HIPK1 |
0.793 | 0.544 | 1 | 0.808 |
ERK2 |
0.792 | 0.641 | 1 | 0.850 |
JNK1 |
0.790 | 0.613 | 1 | 0.901 |
NLK |
0.788 | 0.553 | 1 | 0.686 |
DYRK1B |
0.788 | 0.558 | 1 | 0.865 |
HIPK3 |
0.787 | 0.530 | 1 | 0.808 |
CDK10 |
0.784 | 0.569 | 1 | 0.885 |
DYRK1A |
0.784 | 0.473 | 1 | 0.811 |
CDK4 |
0.780 | 0.606 | 1 | 0.908 |
SRPK1 |
0.780 | 0.241 | -3 | 0.667 |
ERK5 |
0.779 | 0.318 | 1 | 0.566 |
CDK6 |
0.778 | 0.577 | 1 | 0.892 |
CDK2 |
0.776 | 0.448 | 1 | 0.796 |
MAK |
0.774 | 0.432 | -2 | 0.807 |
ICK |
0.772 | 0.304 | -3 | 0.776 |
COT |
0.772 | -0.022 | 2 | 0.770 |
MTOR |
0.772 | 0.165 | 1 | 0.505 |
DYRK3 |
0.771 | 0.418 | 1 | 0.779 |
CLK1 |
0.771 | 0.302 | -3 | 0.659 |
SRPK2 |
0.770 | 0.190 | -3 | 0.589 |
CLK2 |
0.769 | 0.293 | -3 | 0.665 |
TBK1 |
0.768 | -0.065 | 1 | 0.353 |
CLK4 |
0.768 | 0.281 | -3 | 0.679 |
CDKL5 |
0.766 | 0.146 | -3 | 0.725 |
CHAK2 |
0.766 | 0.145 | -1 | 0.859 |
CDKL1 |
0.762 | 0.110 | -3 | 0.728 |
IKKE |
0.761 | -0.093 | 1 | 0.354 |
PRPK |
0.760 | -0.027 | -1 | 0.804 |
MOK |
0.760 | 0.390 | 1 | 0.685 |
DSTYK |
0.759 | -0.061 | 2 | 0.778 |
NEK6 |
0.757 | -0.017 | -2 | 0.838 |
PRP4 |
0.757 | 0.339 | -3 | 0.700 |
CDC7 |
0.757 | -0.093 | 1 | 0.312 |
ULK2 |
0.757 | -0.118 | 2 | 0.657 |
SRPK3 |
0.757 | 0.144 | -3 | 0.633 |
PDHK4 |
0.756 | -0.076 | 1 | 0.405 |
IKKB |
0.756 | -0.116 | -2 | 0.677 |
ATR |
0.755 | -0.024 | 1 | 0.364 |
TGFBR2 |
0.754 | -0.019 | -2 | 0.814 |
MOS |
0.754 | -0.048 | 1 | 0.355 |
WNK1 |
0.754 | -0.042 | -2 | 0.836 |
RAF1 |
0.753 | -0.167 | 1 | 0.354 |
NDR2 |
0.752 | -0.040 | -3 | 0.786 |
NEK7 |
0.752 | -0.092 | -3 | 0.814 |
MARK4 |
0.752 | -0.027 | 4 | 0.827 |
PRKD1 |
0.752 | -0.024 | -3 | 0.773 |
RIPK3 |
0.752 | -0.121 | 3 | 0.490 |
IKKA |
0.751 | -0.052 | -2 | 0.679 |
BMPR2 |
0.751 | -0.103 | -2 | 0.847 |
GCN2 |
0.751 | -0.178 | 2 | 0.647 |
PKN3 |
0.751 | -0.056 | -3 | 0.771 |
PIM3 |
0.750 | -0.054 | -3 | 0.772 |
FAM20C |
0.750 | 0.100 | 2 | 0.711 |
MST4 |
0.749 | -0.048 | 2 | 0.734 |
ERK7 |
0.749 | 0.192 | 2 | 0.438 |
SKMLCK |
0.749 | -0.034 | -2 | 0.818 |
ULK1 |
0.748 | -0.112 | -3 | 0.799 |
PDHK1 |
0.748 | -0.158 | 1 | 0.399 |
CAMK1B |
0.748 | -0.060 | -3 | 0.786 |
PKCD |
0.748 | -0.023 | 2 | 0.678 |
CAMK2G |
0.747 | -0.096 | 2 | 0.687 |
MLK1 |
0.746 | -0.111 | 2 | 0.700 |
PAK6 |
0.746 | 0.036 | -2 | 0.667 |
NUAK2 |
0.746 | -0.025 | -3 | 0.775 |
CAMLCK |
0.746 | -0.027 | -2 | 0.802 |
HUNK |
0.745 | -0.131 | 2 | 0.673 |
MLK2 |
0.745 | -0.050 | 2 | 0.711 |
NEK9 |
0.745 | -0.104 | 2 | 0.709 |
NIK |
0.745 | -0.085 | -3 | 0.813 |
NDR1 |
0.744 | -0.068 | -3 | 0.770 |
CAMK2D |
0.744 | -0.059 | -3 | 0.783 |
TGFBR1 |
0.743 | 0.023 | -2 | 0.833 |
AMPKA1 |
0.743 | -0.061 | -3 | 0.790 |
LATS2 |
0.743 | -0.035 | -5 | 0.726 |
P90RSK |
0.743 | -0.029 | -3 | 0.701 |
RSK2 |
0.743 | -0.030 | -3 | 0.697 |
ALK4 |
0.743 | 0.015 | -2 | 0.854 |
AURC |
0.743 | 0.019 | -2 | 0.608 |
MNK2 |
0.743 | -0.005 | -2 | 0.746 |
GRK1 |
0.742 | -0.035 | -2 | 0.691 |
PRKD2 |
0.742 | -0.032 | -3 | 0.704 |
RSK3 |
0.742 | -0.034 | -3 | 0.689 |
BMPR1B |
0.741 | 0.008 | 1 | 0.271 |
WNK3 |
0.741 | -0.180 | 1 | 0.349 |
DNAPK |
0.741 | -0.021 | 1 | 0.364 |
MLK3 |
0.741 | -0.051 | 2 | 0.647 |
IRE1 |
0.741 | -0.097 | 1 | 0.306 |
MAPKAPK3 |
0.740 | -0.059 | -3 | 0.715 |
NIM1 |
0.740 | -0.089 | 3 | 0.514 |
TSSK1 |
0.739 | -0.046 | -3 | 0.813 |
AMPKA2 |
0.739 | -0.049 | -3 | 0.755 |
DAPK2 |
0.739 | -0.066 | -3 | 0.800 |
PKN2 |
0.739 | -0.093 | -3 | 0.768 |
TTBK2 |
0.739 | -0.132 | 2 | 0.598 |
PHKG1 |
0.739 | -0.061 | -3 | 0.753 |
BCKDK |
0.738 | -0.143 | -1 | 0.684 |
PIM1 |
0.738 | -0.023 | -3 | 0.705 |
PAK3 |
0.738 | -0.052 | -2 | 0.734 |
MASTL |
0.738 | -0.171 | -2 | 0.765 |
PKCB |
0.738 | -0.033 | 2 | 0.644 |
LATS1 |
0.737 | 0.029 | -3 | 0.811 |
PLK4 |
0.737 | -0.071 | 2 | 0.491 |
PKACG |
0.737 | -0.046 | -2 | 0.662 |
GRK5 |
0.736 | -0.166 | -3 | 0.800 |
P70S6KB |
0.736 | -0.038 | -3 | 0.716 |
TLK2 |
0.736 | -0.036 | 1 | 0.326 |
ANKRD3 |
0.736 | -0.152 | 1 | 0.369 |
MPSK1 |
0.736 | 0.085 | 1 | 0.350 |
VRK2 |
0.736 | 0.058 | 1 | 0.434 |
PKCA |
0.736 | -0.040 | 2 | 0.625 |
TSSK2 |
0.736 | -0.085 | -5 | 0.793 |
CAMK2B |
0.735 | -0.045 | 2 | 0.693 |
ATM |
0.735 | -0.073 | 1 | 0.325 |
PAK1 |
0.735 | -0.050 | -2 | 0.744 |
PKCZ |
0.735 | -0.037 | 2 | 0.660 |
GRK7 |
0.735 | -0.021 | 1 | 0.339 |
QSK |
0.734 | -0.049 | 4 | 0.813 |
MAPKAPK2 |
0.734 | -0.055 | -3 | 0.667 |
PKCG |
0.734 | -0.054 | 2 | 0.631 |
CHAK1 |
0.734 | -0.080 | 2 | 0.642 |
IRE2 |
0.734 | -0.111 | 2 | 0.637 |
RIPK1 |
0.733 | -0.192 | 1 | 0.325 |
NEK2 |
0.733 | -0.101 | 2 | 0.678 |
NUAK1 |
0.733 | -0.065 | -3 | 0.718 |
MLK4 |
0.732 | -0.094 | 2 | 0.622 |
DLK |
0.732 | -0.203 | 1 | 0.359 |
SMG1 |
0.732 | -0.060 | 1 | 0.337 |
PLK1 |
0.732 | -0.116 | -2 | 0.783 |
MNK1 |
0.731 | -0.035 | -2 | 0.742 |
ACVR2A |
0.731 | -0.042 | -2 | 0.802 |
PKR |
0.731 | -0.090 | 1 | 0.342 |
PKG2 |
0.730 | -0.017 | -2 | 0.603 |
ALK2 |
0.730 | -0.010 | -2 | 0.822 |
SGK3 |
0.730 | -0.023 | -3 | 0.693 |
YSK4 |
0.729 | -0.147 | 1 | 0.340 |
QIK |
0.729 | -0.110 | -3 | 0.771 |
AURB |
0.729 | -0.022 | -2 | 0.607 |
GRK6 |
0.728 | -0.171 | 1 | 0.333 |
MARK3 |
0.728 | -0.053 | 4 | 0.766 |
PKCH |
0.728 | -0.075 | 2 | 0.614 |
RSK4 |
0.728 | -0.030 | -3 | 0.676 |
PINK1 |
0.728 | 0.076 | 1 | 0.492 |
ACVR2B |
0.728 | -0.050 | -2 | 0.801 |
PRKD3 |
0.728 | -0.053 | -3 | 0.658 |
GRK4 |
0.727 | -0.171 | -2 | 0.760 |
MELK |
0.727 | -0.100 | -3 | 0.736 |
BRSK2 |
0.727 | -0.093 | -3 | 0.744 |
CAMK2A |
0.727 | -0.062 | 2 | 0.670 |
PKACB |
0.727 | -0.010 | -2 | 0.613 |
MEK1 |
0.727 | -0.136 | 2 | 0.702 |
MARK2 |
0.727 | -0.054 | 4 | 0.729 |
GSK3A |
0.727 | 0.121 | 4 | 0.359 |
MSK2 |
0.727 | -0.069 | -3 | 0.662 |
WNK4 |
0.727 | -0.086 | -2 | 0.846 |
PAK2 |
0.727 | -0.079 | -2 | 0.729 |
NEK5 |
0.726 | -0.080 | 1 | 0.334 |
BRSK1 |
0.725 | -0.086 | -3 | 0.714 |
SIK |
0.725 | -0.078 | -3 | 0.678 |
MEKK1 |
0.725 | -0.127 | 1 | 0.378 |
PAK4 |
0.724 | -0.001 | -2 | 0.619 |
BMPR1A |
0.724 | -0.010 | 1 | 0.266 |
CHK1 |
0.723 | -0.070 | -3 | 0.789 |
PAK5 |
0.723 | -0.016 | -2 | 0.605 |
AKT2 |
0.723 | -0.013 | -3 | 0.603 |
PKCT |
0.723 | -0.057 | 2 | 0.626 |
MAPKAPK5 |
0.723 | -0.094 | -3 | 0.652 |
PLK3 |
0.723 | -0.122 | 2 | 0.628 |
MSK1 |
0.722 | -0.050 | -3 | 0.673 |
ZAK |
0.722 | -0.133 | 1 | 0.358 |
IRAK4 |
0.722 | -0.112 | 1 | 0.306 |
MEKK2 |
0.722 | -0.105 | 2 | 0.687 |
CAMK4 |
0.721 | -0.159 | -3 | 0.751 |
TLK1 |
0.721 | -0.076 | -2 | 0.807 |
DCAMKL1 |
0.721 | -0.058 | -3 | 0.710 |
MST3 |
0.720 | -0.063 | 2 | 0.707 |
PERK |
0.720 | -0.129 | -2 | 0.804 |
MYLK4 |
0.720 | -0.069 | -2 | 0.709 |
PHKG2 |
0.720 | -0.092 | -3 | 0.717 |
MARK1 |
0.720 | -0.092 | 4 | 0.785 |
HRI |
0.720 | -0.153 | -2 | 0.829 |
BRAF |
0.720 | -0.124 | -4 | 0.834 |
CK1E |
0.719 | -0.035 | -3 | 0.496 |
SSTK |
0.718 | -0.057 | 4 | 0.804 |
MEK5 |
0.718 | -0.175 | 2 | 0.688 |
AURA |
0.718 | -0.040 | -2 | 0.593 |
TAO3 |
0.717 | -0.074 | 1 | 0.378 |
CK1G1 |
0.717 | -0.049 | -3 | 0.473 |
PIM2 |
0.716 | -0.038 | -3 | 0.667 |
PKCI |
0.716 | -0.048 | 2 | 0.626 |
TTBK1 |
0.716 | -0.135 | 2 | 0.521 |
AKT1 |
0.716 | -0.029 | -3 | 0.629 |
MAP3K15 |
0.716 | -0.054 | 1 | 0.367 |
PRKX |
0.715 | -0.017 | -3 | 0.607 |
SNRK |
0.715 | -0.189 | 2 | 0.521 |
GRK2 |
0.714 | -0.101 | -2 | 0.663 |
MEKK3 |
0.714 | -0.192 | 1 | 0.358 |
DRAK1 |
0.714 | -0.171 | 1 | 0.282 |
NEK11 |
0.714 | -0.125 | 1 | 0.386 |
PDK1 |
0.714 | -0.061 | 1 | 0.378 |
DCAMKL2 |
0.714 | -0.077 | -3 | 0.733 |
NEK4 |
0.714 | -0.107 | 1 | 0.337 |
MEKK6 |
0.713 | -0.062 | 1 | 0.359 |
LKB1 |
0.712 | -0.050 | -3 | 0.801 |
PKCE |
0.712 | -0.032 | 2 | 0.619 |
NEK8 |
0.711 | -0.152 | 2 | 0.679 |
TNIK |
0.711 | -0.043 | 3 | 0.522 |
PASK |
0.711 | -0.078 | -3 | 0.799 |
PKACA |
0.711 | -0.026 | -2 | 0.560 |
GSK3B |
0.710 | -0.005 | 4 | 0.353 |
CAMK1G |
0.710 | -0.105 | -3 | 0.679 |
BUB1 |
0.710 | 0.014 | -5 | 0.748 |
NEK1 |
0.709 | -0.084 | 1 | 0.326 |
TAO2 |
0.709 | -0.096 | 2 | 0.726 |
HGK |
0.709 | -0.080 | 3 | 0.511 |
PKN1 |
0.709 | -0.060 | -3 | 0.648 |
GAK |
0.708 | -0.061 | 1 | 0.358 |
CK1D |
0.708 | -0.029 | -3 | 0.450 |
SMMLCK |
0.707 | -0.089 | -3 | 0.742 |
VRK1 |
0.707 | -0.062 | 2 | 0.722 |
GCK |
0.706 | -0.104 | 1 | 0.363 |
EEF2K |
0.706 | -0.094 | 3 | 0.484 |
KHS1 |
0.706 | -0.063 | 1 | 0.362 |
MST2 |
0.705 | -0.118 | 1 | 0.357 |
CAMKK2 |
0.705 | -0.129 | -2 | 0.663 |
IRAK1 |
0.705 | -0.214 | -1 | 0.691 |
MINK |
0.705 | -0.114 | 1 | 0.344 |
CK1A2 |
0.704 | -0.043 | -3 | 0.444 |
HASPIN |
0.704 | 0.008 | -1 | 0.708 |
CAMKK1 |
0.704 | -0.182 | -2 | 0.663 |
P70S6K |
0.703 | -0.086 | -3 | 0.628 |
LOK |
0.702 | -0.094 | -2 | 0.684 |
CK2A2 |
0.702 | -0.094 | 1 | 0.214 |
ROCK2 |
0.702 | -0.021 | -3 | 0.716 |
NEK3 |
0.701 | -0.073 | 1 | 0.365 |
KHS2 |
0.701 | -0.055 | 1 | 0.369 |
AKT3 |
0.701 | -0.024 | -3 | 0.546 |
DAPK3 |
0.701 | -0.068 | -3 | 0.718 |
GRK3 |
0.701 | -0.099 | -2 | 0.622 |
LRRK2 |
0.701 | -0.072 | 2 | 0.693 |
HPK1 |
0.701 | -0.100 | 1 | 0.365 |
CAMK1D |
0.701 | -0.078 | -3 | 0.600 |
SGK1 |
0.700 | -0.015 | -3 | 0.529 |
PBK |
0.699 | -0.041 | 1 | 0.331 |
YSK1 |
0.699 | -0.108 | 2 | 0.685 |
MRCKB |
0.699 | -0.030 | -3 | 0.652 |
MST1 |
0.697 | -0.132 | 1 | 0.345 |
PLK2 |
0.697 | -0.085 | -3 | 0.734 |
MEK2 |
0.697 | -0.154 | 2 | 0.678 |
SLK |
0.695 | -0.097 | -2 | 0.632 |
STK33 |
0.694 | -0.140 | 2 | 0.483 |
CHK2 |
0.694 | -0.064 | -3 | 0.549 |
TAK1 |
0.694 | -0.194 | 1 | 0.336 |
PKG1 |
0.694 | -0.047 | -2 | 0.517 |
SBK |
0.694 | 0.032 | -3 | 0.489 |
RIPK2 |
0.694 | -0.215 | 1 | 0.344 |
CK2A1 |
0.693 | -0.100 | 1 | 0.203 |
BIKE |
0.692 | -0.024 | 1 | 0.322 |
DAPK1 |
0.692 | -0.079 | -3 | 0.695 |
ASK1 |
0.691 | -0.097 | 1 | 0.365 |
TTK |
0.691 | -0.080 | -2 | 0.810 |
CAMK1A |
0.690 | -0.071 | -3 | 0.565 |
MRCKA |
0.690 | -0.061 | -3 | 0.674 |
AAK1 |
0.690 | 0.016 | 1 | 0.299 |
PDHK3_TYR |
0.689 | 0.101 | 4 | 0.857 |
DMPK1 |
0.689 | -0.016 | -3 | 0.674 |
OSR1 |
0.689 | -0.079 | 2 | 0.667 |
ROCK1 |
0.687 | -0.036 | -3 | 0.670 |
LIMK2_TYR |
0.686 | 0.121 | -3 | 0.846 |
PKMYT1_TYR |
0.685 | 0.078 | 3 | 0.548 |
TAO1 |
0.685 | -0.101 | 1 | 0.359 |
MYO3B |
0.684 | -0.088 | 2 | 0.699 |
CRIK |
0.683 | -0.036 | -3 | 0.639 |
MYO3A |
0.682 | -0.107 | 1 | 0.355 |
TESK1_TYR |
0.682 | 0.001 | 3 | 0.555 |
JAK2 |
0.681 | -0.045 | 1 | 0.393 |
YANK3 |
0.679 | -0.075 | 2 | 0.319 |
PDHK4_TYR |
0.678 | -0.012 | 2 | 0.720 |
CSF1R |
0.678 | -0.063 | 3 | 0.522 |
MAP2K7_TYR |
0.678 | -0.094 | 2 | 0.711 |
ALPHAK3 |
0.677 | -0.110 | -1 | 0.719 |
RET |
0.677 | -0.096 | 1 | 0.374 |
MAP2K4_TYR |
0.676 | -0.058 | -1 | 0.797 |
MST1R |
0.675 | -0.096 | 3 | 0.533 |
ROS1 |
0.675 | -0.093 | 3 | 0.500 |
JAK1 |
0.674 | -0.051 | 1 | 0.371 |
TYK2 |
0.674 | -0.148 | 1 | 0.369 |
MAP2K6_TYR |
0.674 | -0.048 | -1 | 0.803 |
PDHK1_TYR |
0.673 | -0.091 | -1 | 0.813 |
ABL2 |
0.672 | -0.066 | -1 | 0.736 |
PINK1_TYR |
0.672 | -0.152 | 1 | 0.374 |
TNK1 |
0.671 | -0.035 | 3 | 0.515 |
STLK3 |
0.671 | -0.160 | 1 | 0.343 |
LIMK1_TYR |
0.671 | -0.027 | 2 | 0.723 |
BMPR2_TYR |
0.671 | -0.053 | -1 | 0.786 |
TYRO3 |
0.671 | -0.133 | 3 | 0.503 |
EPHA6 |
0.670 | -0.077 | -1 | 0.770 |
CK1A |
0.670 | -0.062 | -3 | 0.358 |
TNK2 |
0.670 | -0.077 | 3 | 0.508 |
EPHB4 |
0.669 | -0.090 | -1 | 0.739 |
YES1 |
0.668 | -0.087 | -1 | 0.772 |
FGFR1 |
0.668 | -0.060 | 3 | 0.506 |
TNNI3K_TYR |
0.667 | -0.037 | 1 | 0.387 |
KDR |
0.666 | -0.092 | 3 | 0.509 |
TXK |
0.666 | -0.057 | 1 | 0.297 |
FGFR2 |
0.666 | -0.071 | 3 | 0.521 |
ABL1 |
0.666 | -0.086 | -1 | 0.726 |
NEK10_TYR |
0.665 | -0.107 | 1 | 0.325 |
JAK3 |
0.664 | -0.126 | 1 | 0.358 |
BLK |
0.664 | -0.068 | -1 | 0.758 |
HCK |
0.664 | -0.118 | -1 | 0.746 |
TEK |
0.664 | -0.052 | 3 | 0.476 |
KIT |
0.664 | -0.117 | 3 | 0.516 |
LCK |
0.663 | -0.083 | -1 | 0.754 |
DDR1 |
0.662 | -0.135 | 4 | 0.765 |
INSRR |
0.662 | -0.138 | 3 | 0.488 |
FGR |
0.661 | -0.143 | 1 | 0.316 |
FER |
0.660 | -0.153 | 1 | 0.328 |
ITK |
0.660 | -0.117 | -1 | 0.716 |
MERTK |
0.660 | -0.127 | 3 | 0.528 |
PDGFRB |
0.660 | -0.182 | 3 | 0.513 |
AXL |
0.660 | -0.149 | 3 | 0.513 |
EPHB1 |
0.659 | -0.143 | 1 | 0.331 |
MET |
0.658 | -0.111 | 3 | 0.522 |
EPHA4 |
0.658 | -0.096 | 2 | 0.628 |
SRMS |
0.658 | -0.154 | 1 | 0.311 |
EPHB3 |
0.657 | -0.136 | -1 | 0.718 |
EPHB2 |
0.656 | -0.124 | -1 | 0.711 |
FLT3 |
0.656 | -0.177 | 3 | 0.503 |
FYN |
0.656 | -0.080 | -1 | 0.736 |
ALK |
0.656 | -0.151 | 3 | 0.469 |
FGFR3 |
0.655 | -0.094 | 3 | 0.509 |
BMX |
0.654 | -0.095 | -1 | 0.663 |
DDR2 |
0.654 | -0.057 | 3 | 0.481 |
PDGFRA |
0.654 | -0.207 | 3 | 0.501 |
INSR |
0.653 | -0.136 | 3 | 0.486 |
FRK |
0.653 | -0.129 | -1 | 0.758 |
LTK |
0.653 | -0.152 | 3 | 0.504 |
NTRK3 |
0.652 | -0.121 | -1 | 0.675 |
EPHA1 |
0.651 | -0.139 | 3 | 0.523 |
EPHA7 |
0.651 | -0.127 | 2 | 0.628 |
LYN |
0.650 | -0.126 | 3 | 0.464 |
ERBB2 |
0.650 | -0.157 | 1 | 0.338 |
CK1G3 |
0.650 | -0.072 | -3 | 0.310 |
NTRK1 |
0.650 | -0.186 | -1 | 0.713 |
TEC |
0.649 | -0.147 | -1 | 0.669 |
FLT4 |
0.649 | -0.165 | 3 | 0.503 |
YANK2 |
0.648 | -0.088 | 2 | 0.343 |
BTK |
0.647 | -0.164 | -1 | 0.684 |
EGFR |
0.647 | -0.094 | 1 | 0.307 |
PTK2B |
0.647 | -0.112 | -1 | 0.707 |
SRC |
0.647 | -0.116 | -1 | 0.731 |
FLT1 |
0.646 | -0.157 | -1 | 0.727 |
FGFR4 |
0.646 | -0.099 | -1 | 0.678 |
WEE1_TYR |
0.646 | -0.129 | -1 | 0.692 |
CSK |
0.644 | -0.124 | 2 | 0.634 |
EPHA8 |
0.644 | -0.110 | -1 | 0.709 |
NTRK2 |
0.643 | -0.242 | 3 | 0.462 |
EPHA3 |
0.641 | -0.164 | 2 | 0.600 |
PTK6 |
0.641 | -0.203 | -1 | 0.656 |
MATK |
0.641 | -0.108 | -1 | 0.677 |
EPHA5 |
0.640 | -0.146 | 2 | 0.616 |
MUSK |
0.637 | -0.134 | 1 | 0.286 |
IGF1R |
0.637 | -0.143 | 3 | 0.443 |
ERBB4 |
0.637 | -0.093 | 1 | 0.296 |
EPHA2 |
0.637 | -0.124 | -1 | 0.664 |
CK1G2 |
0.635 | -0.070 | -3 | 0.398 |
PTK2 |
0.633 | -0.083 | -1 | 0.686 |
SYK |
0.631 | -0.096 | -1 | 0.681 |
ZAP70 |
0.628 | -0.055 | -1 | 0.631 |
FES |
0.621 | -0.154 | -1 | 0.635 |