Motif 168 (n=120)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| O00264 | PGRMC1 | S54 | ochoa|psp | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021). {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:30443021, ECO:0000303|PubMed:28396637}. |
| O14526 | FCHO1 | S576 | ochoa | F-BAR domain only protein 1 | Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969). {ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:30822429, ECO:0000269|PubMed:32098969}. |
| O14607 | UTY | S765 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O14715 | RGPD8 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15550 | KDM6A | S818 | ochoa | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17761849, PubMed:17851529). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17713478, PubMed:17761849, PubMed:17851529). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). {ECO:0000250|UniProtKB:O70546, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17761849, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914}. |
| O60271 | SPAG9 | S242 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60941 | DTNB | S535 | ochoa | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| O75081 | CBFA2T3 | S328 | ochoa | Protein CBFA2T3 (MTG8-related protein 2) (Myeloid translocation gene on chromosome 16 protein) (hMTG16) (Zinc finger MYND domain-containing protein 4) | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}. |
| O75376 | NCOR1 | S2136 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75410 | TACC1 | S248 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
| O75864 | PPP1R37 | S586 | ochoa | Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) | Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269|PubMed:19389623}. |
| O75886 | STAM2 | S372 | ochoa | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
| O76080 | ZFAND5 | S128 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O95239 | KIF4A | S1013 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95359 | TACC2 | S2436 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S2440 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | S2562 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | S2318 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P06400 | RB1 | S773 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P07451 | CA3 | S227 | ochoa | Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) | Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:18618712}. |
| P0DJD0 | RGPD1 | S772 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S780 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P13807 | GYS1 | Y634 | ochoa|psp | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P16144 | ITGB4 | S1111 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P20807 | CAPN3 | S629 | psp | Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) | Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:27657329}. |
| P23588 | EIF4B | S495 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P27816 | MAP4 | S609 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28324 | ELK4 | S215 | ochoa | ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
| P35712 | SOX6 | S439 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P37275 | ZEB1 | S693 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P38398 | BRCA1 | S1180 | ochoa | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
| P40818 | USP8 | S389 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P41162 | ETV3 | S132 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
| P41212 | ETV6 | S22 | ochoa|psp | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41212 | ETV6 | S184 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P49792 | RANBP2 | S781 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51003 | PAPOLA | S526 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P52569 | SLC7A2 | S446 | ochoa | Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) | Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}. |
| P54259 | ATN1 | S739 | ochoa|psp | Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein) | Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. {ECO:0000250|UniProtKB:O35126, ECO:0000269|PubMed:10085113, ECO:0000269|PubMed:10973986}. |
| P98174 | FGD1 | S715 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q02952 | AKAP12 | S554 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q08174 | PCDH1 | S1018 | ochoa | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | May be involved in cell-cell interaction processes and in cell adhesion. |
| Q08999 | RBL2 | S1035 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q09666 | AHNAK | S5099 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12959 | DLG1 | S158 | psp | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}. |
| Q12968 | NFATC3 | S247 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
| Q13112 | CHAF1B | S403 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13112 | CHAF1B | S451 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13625 | TP53BP2 | S774 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q13772 | NCOA4 | S492 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q13884 | SNTB1 | S219 | ochoa | Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. |
| Q14157 | UBAP2L | S439 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14289 | PTK2B | S747 | ochoa | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Q14766 | LTBP1 | S494 | ochoa | Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:15184403, PubMed:8617200, PubMed:8939931). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). {ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:2022183, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:8617200, ECO:0000269|PubMed:8939931}. |
| Q15021 | NCAPD2 | S1330 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15059 | BRD3 | S254 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15911 | ZFHX3 | S3409 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16666 | IFI16 | S142 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q3KR37 | GRAMD1B | S21 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q3T8J9 | GON4L | S998 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q53HC0 | CCDC92 | S183 | ochoa | Coiled-coil domain-containing protein 92 (Limkain beta-2) | Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. {ECO:0000269|PubMed:32528005}. |
| Q5M775 | SPECC1 | S131 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5QJE6 | DNTTIP2 | S236 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5SY16 | NOL9 | S242 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q5VYV7 | SLX4IP | S271 | ochoa | Protein SLX4IP (SLX4-interacting protein) | None |
| Q658Y4 | FAM91A1 | S340 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q6F5E8 | CARMIL2 | S1319 | ochoa | Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}. |
| Q6IQ23 | PLEKHA7 | S856 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
| Q6JBY9 | RCSD1 | S105 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q70E73 | RAPH1 | S1066 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q76L83 | ASXL2 | S1285 | ochoa | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}. |
| Q7RTP6 | MICAL3 | S1173 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2Z1 | TICRR | S1346 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z3J3 | RGPD4 | S782 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6I6 | ARHGAP30 | S1034 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86UU1 | PHLDB1 | S461 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86V42 | FAM124A | S318 | ochoa | Protein FAM124A | None |
| Q86WB0 | ZC3HC1 | S335 | ochoa | Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase) | Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR. {ECO:0000269|PubMed:34440706}. |
| Q86X27 | RALGPS2 | S293 | ochoa | Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2) | Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}. |
| Q86XJ1 | GAS2L3 | S607 | ochoa | GAS2-like protein 3 (Growth arrest-specific protein 2-like 3) | Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}. |
| Q86XL3 | ANKLE2 | S866 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q86YP4 | GATAD2A | S182 | ochoa | Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) | Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| Q8IV36 | HID1 | S633 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q8IZP0 | ABI1 | S216 | ochoa|psp | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Q8N8Z6 | DCBLD1 | S616 | ochoa|psp | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8NFA0 | USP32 | S1361 | ochoa | Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) | Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269|PubMed:36476874}. |
| Q92870 | APBB2 | S330 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q969V6 | MRTFA | S792 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96AY4 | TTC28 | S1372 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96B33 | CLDN23 | S203 | ochoa | Claudin-23 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}. |
| Q96JK9 | MAML3 | S364 | ochoa | Mastermind-like protein 3 (Mam-3) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}. |
| Q96JM3 | CHAMP1 | S108 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
| Q96QT4 | TRPM7 | S1493 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96T37 | RBM15 | S659 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99618 | CDCA3 | S165 | ochoa | Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) | F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}. |
| Q99666 | RGPD5 | S781 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BTC0 | DIDO1 | S1019 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BY44 | EIF2A | S503 | ochoa | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. {ECO:0000269|PubMed:12133843}. |
| Q9C0K0 | BCL11B | S398 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H1A4 | ANAPC1 | S518 | ochoa | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9H1E3 | NUCKS1 | S195 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H211 | CDT1 | S143 | psp | DNA replication factor Cdt1 (Double parked homolog) (DUP) | Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055, ECO:0000269|PubMed:26842564}. |
| Q9H869 | YY1AP1 | S455 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9HC35 | EML4 | S888 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9P0V3 | SH3BP4 | S264 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P219 | CCDC88C | S1432 | ochoa | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269|PubMed:26126266, ECO:0000269|PubMed:30948426}. |
| Q9P2D0 | IBTK | S1083 | ochoa | Inhibitor of Bruton tyrosine kinase (IBtk) | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}. |
| Q9UHB7 | AFF4 | S487 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UIF9 | BAZ2A | S1207 | ochoa | Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) | Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250|UniProtKB:Q91YE5, ECO:0000269|PubMed:28801535}. |
| Q9UQ35 | SRRM2 | S1311 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQR0 | SCML2 | S499 | ochoa|psp | Sex comb on midleg-like protein 2 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}. |
| Q9Y478 | PRKAB1 | S174 | psp | 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
| Q9Y4F1 | FARP1 | S418 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4F1 | FARP1 | S503 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y6G9 | DYNC1LI1 | S412 | ochoa | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
| Q9Y6R4 | MAP3K4 | S420 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| Q9Y6X9 | MORC2 | S696 | ochoa | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| O43781 | DYRK3 | S47 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) | Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (PubMed:29973724). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues (PubMed:29634919, PubMed:9748265). Acts as a central dissolvase of membraneless organelles during the G2-to-M transition, after the nuclear-envelope breakdown: acts by mediating phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, such as SRRM1 and PCM1 (PubMed:29973724). Does not mediate disassembly of all membraneless organelles: disassembly of P-body and nucleolus is not regulated by DYRK3 (PubMed:29973724). Dissolution of membraneless organelles at the onset of mitosis is also required to release mitotic regulators, such as ZNF207, from liquid-unmixed organelles where they are sequestered and keep them dissolved during mitosis (PubMed:29973724). Regulates mTORC1 by mediating the dissolution of stress granules: during stressful conditions, DYRK3 partitions from the cytosol to the stress granule, together with mTORC1 components, which prevents mTORC1 signaling (PubMed:23415227). When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol: acts by mediating the phosphorylation of the mTORC1 inhibitor AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Also acts as a negative regulator of EPO-dependent erythropoiesis: may place an upper limit on red cell production during stress erythropoiesis (PubMed:10779429). Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1: this in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). {ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:29634919, ECO:0000269|PubMed:29973724, ECO:0000269|PubMed:9748265}. |
| P11362 | FGFR1 | S436 | Sugiyama | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 0.007671 | 2.115 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015284 | 1.816 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015284 | 1.816 |
| R-HSA-1839120 | Signaling by FGFR1 amplification mutants | 0.000717 | 3.145 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 0.030336 | 1.518 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 0.030336 | 1.518 |
| R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions | 0.037776 | 1.423 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.045160 | 1.345 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.004655 | 2.332 |
| R-HSA-190374 | FGFR1c and Klotho ligand binding and activation | 0.052487 | 1.280 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.052487 | 1.280 |
| R-HSA-1839122 | Signaling by activated point mutants of FGFR1 | 0.006136 | 2.212 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.059759 | 1.224 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.010640 | 1.973 |
| R-HSA-72731 | Recycling of eIF2:GDP | 0.074136 | 1.130 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.012746 | 1.895 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.081243 | 1.090 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.081243 | 1.090 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.081243 | 1.090 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.088296 | 1.054 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.018727 | 1.728 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.018727 | 1.728 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.020040 | 1.698 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 0.022777 | 1.642 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.109133 | 0.962 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 0.024201 | 1.616 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.115973 | 0.936 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.115973 | 0.936 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.122762 | 0.911 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.122762 | 0.911 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.031839 | 1.497 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.142817 | 0.845 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.142817 | 0.845 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.168853 | 0.772 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.168853 | 0.772 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.175238 | 0.756 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.175238 | 0.756 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.175238 | 0.756 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.175238 | 0.756 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.175238 | 0.756 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.175238 | 0.756 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.181575 | 0.741 |
| R-HSA-429947 | Deadenylation of mRNA | 0.206442 | 0.685 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.080870 | 1.092 |
| R-HSA-72649 | Translation initiation complex formation | 0.083138 | 1.080 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.212541 | 0.673 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.087732 | 1.057 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.230559 | 0.637 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.236474 | 0.626 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.236474 | 0.626 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.242344 | 0.616 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.248169 | 0.605 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.248169 | 0.605 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.259686 | 0.586 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.259686 | 0.586 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.265379 | 0.576 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.163847 | 0.786 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.163847 | 0.786 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.042073 | 1.376 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.242344 | 0.616 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.181575 | 0.741 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.023557 | 1.628 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.023557 | 1.628 |
| R-HSA-9646399 | Aggrephagy | 0.051408 | 1.289 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.013862 | 1.858 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 0.020040 | 1.698 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.023557 | 1.628 |
| R-HSA-1538133 | G0 and Early G1 | 0.253950 | 0.595 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.067495 | 1.171 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.271028 | 0.567 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.124333 | 0.905 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.124333 | 0.905 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.115973 | 0.936 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.242344 | 0.616 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.054997 | 1.260 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.087732 | 1.057 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.088296 | 1.054 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.109133 | 0.962 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.122762 | 0.911 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.155935 | 0.807 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.072001 | 1.143 |
| R-HSA-1221632 | Meiotic synapsis | 0.080870 | 1.092 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.259686 | 0.586 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.166031 | 0.780 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.265379 | 0.576 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.218593 | 0.660 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.264629 | 0.577 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.224905 | 0.648 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.224905 | 0.648 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.006644 | 2.178 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.035127 | 1.454 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.149401 | 0.826 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.085425 | 1.068 |
| R-HSA-68877 | Mitotic Prometaphase | 0.024614 | 1.609 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.259686 | 0.586 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.187863 | 0.726 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.097139 | 1.013 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.097139 | 1.013 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.097139 | 1.013 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.097139 | 1.013 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.264629 | 0.577 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.044650 | 1.350 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.037776 | 1.423 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.005372 | 2.270 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.095295 | 1.021 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.122762 | 0.911 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.149401 | 0.826 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.168853 | 0.772 |
| R-HSA-3322077 | Glycogen synthesis | 0.175238 | 0.756 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.092400 | 1.034 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.271028 | 0.567 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.271028 | 0.567 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.191278 | 0.718 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.162418 | 0.789 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.242344 | 0.616 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.003541 | 2.451 |
| R-HSA-9620244 | Long-term potentiation | 0.024201 | 1.616 |
| R-HSA-69236 | G1 Phase | 0.061404 | 1.212 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.061404 | 1.212 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.216446 | 0.665 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.271028 | 0.567 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.074136 | 1.130 |
| R-HSA-3229121 | Glycogen storage diseases | 0.155935 | 0.807 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.265379 | 0.576 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.017321 | 1.761 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.038636 | 1.413 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 0.115973 | 0.936 |
| R-HSA-1500620 | Meiosis | 0.161145 | 0.793 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.033467 | 1.475 |
| R-HSA-525793 | Myogenesis | 0.218593 | 0.660 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.059759 | 1.224 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.109133 | 0.962 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.028682 | 1.542 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.129498 | 0.888 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.149401 | 0.826 |
| R-HSA-420029 | Tight junction interactions | 0.212541 | 0.673 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.242344 | 0.616 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.236223 | 0.627 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.236223 | 0.627 |
| R-HSA-9609690 | HCMV Early Events | 0.230490 | 0.637 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.097139 | 1.013 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.137237 | 0.863 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.055330 | 1.257 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.161145 | 0.793 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.206442 | 0.685 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.248169 | 0.605 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.129458 | 0.888 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.002000 | 2.699 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.057400 | 1.241 |
| R-HSA-68886 | M Phase | 0.013098 | 1.883 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.129498 | 0.888 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.036818 | 1.434 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.271028 | 0.567 |
| R-HSA-9612973 | Autophagy | 0.151318 | 0.820 |
| R-HSA-68882 | Mitotic Anaphase | 0.110078 | 0.958 |
| R-HSA-182971 | EGFR downregulation | 0.248169 | 0.605 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.111329 | 0.953 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.036818 | 1.434 |
| R-HSA-1640170 | Cell Cycle | 0.001524 | 2.817 |
| R-HSA-447038 | NrCAM interactions | 0.001391 | 2.857 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.018727 | 1.728 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 0.122762 | 0.911 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.142817 | 0.845 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.200296 | 0.698 |
| R-HSA-9663891 | Selective autophagy | 0.039599 | 1.402 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.236474 | 0.626 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.248169 | 0.605 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.239058 | 0.621 |
| R-HSA-190236 | Signaling by FGFR | 0.205216 | 0.688 |
| R-HSA-1632852 | Macroautophagy | 0.123296 | 0.909 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.265345 | 0.576 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.188505 | 0.725 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.242344 | 0.616 |
| R-HSA-69206 | G1/S Transition | 0.023557 | 1.628 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.025964 | 1.586 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.230559 | 0.637 |
| R-HSA-165159 | MTOR signalling | 0.057330 | 1.242 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.038597 | 1.413 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003367 | 2.473 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.059759 | 1.224 |
| R-HSA-9613354 | Lipophagy | 0.088296 | 1.054 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.115973 | 0.936 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.115973 | 0.936 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.115973 | 0.936 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.136183 | 0.866 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.136183 | 0.866 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.097139 | 1.013 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.149401 | 0.826 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.004642 | 2.333 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.029304 | 1.533 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.013887 | 1.857 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.013887 | 1.857 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.088296 | 1.054 |
| R-HSA-6807004 | Negative regulation of MET activity | 0.016215 | 1.790 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.149401 | 0.826 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 0.155935 | 0.807 |
| R-HSA-109704 | PI3K Cascade | 0.074187 | 1.130 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.218593 | 0.660 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.121789 | 0.914 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.224599 | 0.649 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.026778 | 1.572 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.212541 | 0.673 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.212541 | 0.673 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.121789 | 0.914 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.202419 | 0.694 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.095295 | 1.021 |
| R-HSA-3295583 | TRP channels | 0.218593 | 0.660 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.222083 | 0.653 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.167670 | 0.776 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.013862 | 1.858 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 0.136183 | 0.866 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.194103 | 0.712 |
| R-HSA-3214842 | HDMs demethylate histones | 0.024201 | 1.616 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.008727 | 2.059 |
| R-HSA-112399 | IRS-mediated signalling | 0.090057 | 1.045 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.253950 | 0.595 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.259686 | 0.586 |
| R-HSA-69239 | Synthesis of DNA | 0.233390 | 0.632 |
| R-HSA-9020558 | Interleukin-2 signaling | 0.102240 | 0.990 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.168853 | 0.772 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.194103 | 0.712 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.242344 | 0.616 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.126889 | 0.897 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.122762 | 0.911 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.129498 | 0.888 |
| R-HSA-446728 | Cell junction organization | 0.198232 | 0.703 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.069836 | 1.156 |
| R-HSA-74160 | Gene expression (Transcription) | 0.128757 | 0.890 |
| R-HSA-1500931 | Cell-Cell communication | 0.118688 | 0.926 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.013862 | 1.858 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.018727 | 1.728 |
| R-HSA-445144 | Signal transduction by L1 | 0.175238 | 0.756 |
| R-HSA-69242 | S Phase | 0.040093 | 1.397 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.187863 | 0.726 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.099534 | 1.002 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.187863 | 0.726 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.166558 | 0.778 |
| R-HSA-4839726 | Chromatin organization | 0.057755 | 1.238 |
| R-HSA-373760 | L1CAM interactions | 0.018557 | 1.732 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.082460 | 1.084 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.217533 | 0.662 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.259686 | 0.586 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.259686 | 0.586 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.099534 | 1.002 |
| R-HSA-3000170 | Syndecan interactions | 0.200296 | 0.698 |
| R-HSA-3000157 | Laminin interactions | 0.212541 | 0.673 |
| R-HSA-5688426 | Deubiquitination | 0.163241 | 0.787 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.049486 | 1.306 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.202419 | 0.694 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.106817 | 0.971 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.133536 | 0.874 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 0.094761 | 1.023 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 0.114239 | 0.942 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.267473 | 0.573 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.109276 | 0.961 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.261785 | 0.582 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.122762 | 0.911 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.270318 | 0.568 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.155935 | 0.807 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.225445 | 0.647 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.204482 | 0.689 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.049486 | 1.306 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.106817 | 0.971 |
| R-HSA-6806834 | Signaling by MET | 0.147764 | 0.830 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.129498 | 0.888 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.168853 | 0.772 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.041581 | 1.381 |
| R-HSA-1474244 | Extracellular matrix organization | 0.135371 | 0.868 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.185739 | 0.731 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.259686 | 0.586 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.106365 | 0.973 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.208018 | 0.682 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.215726 | 0.666 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.227076 | 0.644 |
| R-HSA-68875 | Mitotic Prophase | 0.276006 | 0.559 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.276634 | 0.558 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.276634 | 0.558 |
| R-HSA-381042 | PERK regulates gene expression | 0.276634 | 0.558 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.276634 | 0.558 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.276634 | 0.558 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.278849 | 0.555 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.282198 | 0.549 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.282198 | 0.549 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.284534 | 0.546 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.284534 | 0.546 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.284534 | 0.546 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.287719 | 0.541 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.287719 | 0.541 |
| R-HSA-194138 | Signaling by VEGF | 0.293053 | 0.533 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.293198 | 0.533 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.293198 | 0.533 |
| R-HSA-1566948 | Elastic fibre formation | 0.293198 | 0.533 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.298635 | 0.525 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.298635 | 0.525 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.298635 | 0.525 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.298635 | 0.525 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.304030 | 0.517 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.304030 | 0.517 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.304030 | 0.517 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.304030 | 0.517 |
| R-HSA-8982491 | Glycogen metabolism | 0.304030 | 0.517 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.304030 | 0.517 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.304030 | 0.517 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.304030 | 0.517 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.304030 | 0.517 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.304745 | 0.516 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.307221 | 0.513 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.309385 | 0.510 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.309385 | 0.510 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.309385 | 0.510 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.309385 | 0.510 |
| R-HSA-1474165 | Reproduction | 0.310049 | 0.509 |
| R-HSA-9843745 | Adipogenesis | 0.312875 | 0.505 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.313405 | 0.504 |
| R-HSA-162582 | Signal Transduction | 0.314994 | 0.502 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.315698 | 0.501 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.319971 | 0.495 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.325204 | 0.488 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.335550 | 0.474 |
| R-HSA-6807070 | PTEN Regulation | 0.338183 | 0.471 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.340664 | 0.468 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.340664 | 0.468 |
| R-HSA-9675135 | Diseases of DNA repair | 0.340664 | 0.468 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.340664 | 0.468 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.340664 | 0.468 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.341205 | 0.467 |
| R-HSA-9609646 | HCMV Infection | 0.344902 | 0.462 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.345739 | 0.461 |
| R-HSA-437239 | Recycling pathway of L1 | 0.345739 | 0.461 |
| R-HSA-421270 | Cell-cell junction organization | 0.347001 | 0.460 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.350775 | 0.455 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.352127 | 0.453 |
| R-HSA-912446 | Meiotic recombination | 0.365653 | 0.437 |
| R-HSA-9758941 | Gastrulation | 0.368727 | 0.433 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.370537 | 0.431 |
| R-HSA-72187 | mRNA 3'-end processing | 0.370537 | 0.431 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.370537 | 0.431 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.370537 | 0.431 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.370537 | 0.431 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.370537 | 0.431 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.375384 | 0.426 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.375384 | 0.426 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.375384 | 0.426 |
| R-HSA-69306 | DNA Replication | 0.379703 | 0.421 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.380194 | 0.420 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.382435 | 0.417 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.384966 | 0.415 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.384966 | 0.415 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.384966 | 0.415 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.389703 | 0.409 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.389703 | 0.409 |
| R-HSA-177929 | Signaling by EGFR | 0.389703 | 0.409 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.389703 | 0.409 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.389703 | 0.409 |
| R-HSA-9711097 | Cellular response to starvation | 0.393312 | 0.405 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.394403 | 0.404 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.394403 | 0.404 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.398718 | 0.399 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.399067 | 0.399 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.399067 | 0.399 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.403696 | 0.394 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.403696 | 0.394 |
| R-HSA-191859 | snRNP Assembly | 0.403696 | 0.394 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.403696 | 0.394 |
| R-HSA-186712 | Regulation of beta-cell development | 0.403696 | 0.394 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.403696 | 0.394 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.405353 | 0.392 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.408290 | 0.389 |
| R-HSA-983189 | Kinesins | 0.408290 | 0.389 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.408290 | 0.389 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.408290 | 0.389 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.412848 | 0.384 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.412848 | 0.384 |
| R-HSA-9707616 | Heme signaling | 0.417371 | 0.379 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.417371 | 0.379 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.417371 | 0.379 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.417371 | 0.379 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.417371 | 0.379 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.421860 | 0.375 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.421860 | 0.375 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.435122 | 0.361 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.435914 | 0.361 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.435914 | 0.361 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.435914 | 0.361 |
| R-HSA-212436 | Generic Transcription Pathway | 0.437510 | 0.359 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.439475 | 0.357 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.439475 | 0.357 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.443795 | 0.353 |
| R-HSA-195721 | Signaling by WNT | 0.444128 | 0.352 |
| R-HSA-1266738 | Developmental Biology | 0.448648 | 0.348 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.452336 | 0.345 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.452336 | 0.345 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.452336 | 0.345 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.452336 | 0.345 |
| R-HSA-2559583 | Cellular Senescence | 0.454050 | 0.343 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.456557 | 0.341 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.456557 | 0.341 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.460747 | 0.337 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.464904 | 0.333 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.464904 | 0.333 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.464904 | 0.333 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.464904 | 0.333 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.464904 | 0.333 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.469029 | 0.329 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.469029 | 0.329 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.469029 | 0.329 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.469029 | 0.329 |
| R-HSA-69275 | G2/M Transition | 0.469331 | 0.329 |
| R-HSA-380287 | Centrosome maturation | 0.473123 | 0.325 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.473123 | 0.325 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.473123 | 0.325 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.474369 | 0.324 |
| R-HSA-5689603 | UCH proteinases | 0.477186 | 0.321 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.477186 | 0.321 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.481217 | 0.318 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.484358 | 0.315 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.485218 | 0.314 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.485218 | 0.314 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.485218 | 0.314 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.487765 | 0.312 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.493128 | 0.307 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.493128 | 0.307 |
| R-HSA-9833482 | PKR-mediated signaling | 0.493128 | 0.307 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.493591 | 0.307 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.494231 | 0.306 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.497037 | 0.304 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.497037 | 0.304 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.500917 | 0.300 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.500917 | 0.300 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.503985 | 0.298 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.504767 | 0.297 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.508587 | 0.294 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.516141 | 0.287 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.527256 | 0.278 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.534524 | 0.272 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.538117 | 0.269 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.538117 | 0.269 |
| R-HSA-418990 | Adherens junctions interactions | 0.548640 | 0.261 |
| R-HSA-2262752 | Cellular responses to stress | 0.551821 | 0.258 |
| R-HSA-1474290 | Collagen formation | 0.552215 | 0.258 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.562507 | 0.250 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.562507 | 0.250 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.562507 | 0.250 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.562507 | 0.250 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.569238 | 0.245 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.572565 | 0.242 |
| R-HSA-70171 | Glycolysis | 0.575867 | 0.240 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.575867 | 0.240 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.582394 | 0.235 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.588821 | 0.230 |
| R-HSA-199991 | Membrane Trafficking | 0.589852 | 0.229 |
| R-HSA-157118 | Signaling by NOTCH | 0.596771 | 0.224 |
| R-HSA-211000 | Gene Silencing by RNA | 0.601383 | 0.221 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.604463 | 0.219 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.604463 | 0.219 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.616551 | 0.210 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.619515 | 0.208 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.622457 | 0.206 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.625376 | 0.204 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.628272 | 0.202 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.631146 | 0.200 |
| R-HSA-70326 | Glucose metabolism | 0.636829 | 0.196 |
| R-HSA-422475 | Axon guidance | 0.637558 | 0.195 |
| R-HSA-5693538 | Homology Directed Repair | 0.639638 | 0.194 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.642425 | 0.192 |
| R-HSA-3371556 | Cellular response to heat stress | 0.647935 | 0.188 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.652381 | 0.185 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.656043 | 0.183 |
| R-HSA-69481 | G2/M Checkpoints | 0.666566 | 0.176 |
| R-HSA-9909396 | Circadian clock | 0.681755 | 0.166 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.681755 | 0.166 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.682390 | 0.166 |
| R-HSA-9675108 | Nervous system development | 0.686349 | 0.163 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.700944 | 0.154 |
| R-HSA-9664407 | Parasite infection | 0.703260 | 0.153 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.703260 | 0.153 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.703260 | 0.153 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.705559 | 0.151 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.710103 | 0.149 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.710103 | 0.149 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.721162 | 0.142 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.727596 | 0.138 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.729707 | 0.137 |
| R-HSA-112316 | Neuronal System | 0.729949 | 0.137 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.733882 | 0.134 |
| R-HSA-73887 | Death Receptor Signaling | 0.735945 | 0.133 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.737992 | 0.132 |
| R-HSA-1989781 | PPARA activates gene expression | 0.737992 | 0.132 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.742040 | 0.130 |
| R-HSA-9610379 | HCMV Late Events | 0.742040 | 0.130 |
| R-HSA-162587 | HIV Life Cycle | 0.742040 | 0.130 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.744041 | 0.128 |
| R-HSA-109581 | Apoptosis | 0.751890 | 0.124 |
| R-HSA-5619102 | SLC transporter disorders | 0.761366 | 0.118 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.768688 | 0.114 |
| R-HSA-72306 | tRNA processing | 0.768688 | 0.114 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.770368 | 0.113 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.770484 | 0.113 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.772265 | 0.112 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.775787 | 0.110 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.777528 | 0.109 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.777528 | 0.109 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.779414 | 0.108 |
| R-HSA-168255 | Influenza Infection | 0.784358 | 0.105 |
| R-HSA-8953854 | Metabolism of RNA | 0.793993 | 0.100 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.798974 | 0.097 |
| R-HSA-983712 | Ion channel transport | 0.800536 | 0.097 |
| R-HSA-5617833 | Cilium Assembly | 0.802086 | 0.096 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.808168 | 0.092 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.816945 | 0.088 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.819781 | 0.086 |
| R-HSA-913531 | Interferon Signaling | 0.820524 | 0.086 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.821182 | 0.086 |
| R-HSA-72172 | mRNA Splicing | 0.823953 | 0.084 |
| R-HSA-9679506 | SARS-CoV Infections | 0.824169 | 0.084 |
| R-HSA-5357801 | Programmed Cell Death | 0.825323 | 0.083 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.834968 | 0.078 |
| R-HSA-8951664 | Neddylation | 0.845850 | 0.073 |
| R-HSA-162906 | HIV Infection | 0.852915 | 0.069 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.854061 | 0.069 |
| R-HSA-72312 | rRNA processing | 0.858556 | 0.066 |
| R-HSA-72766 | Translation | 0.864143 | 0.063 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.874224 | 0.058 |
| R-HSA-449147 | Signaling by Interleukins | 0.878332 | 0.056 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.882785 | 0.054 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.884311 | 0.053 |
| R-HSA-6798695 | Neutrophil degranulation | 0.885742 | 0.053 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.889041 | 0.051 |
| R-HSA-9658195 | Leishmania infection | 0.903650 | 0.044 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.903650 | 0.044 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.904403 | 0.044 |
| R-HSA-1643685 | Disease | 0.904600 | 0.044 |
| R-HSA-1280218 | Adaptive Immune System | 0.919338 | 0.037 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.929530 | 0.032 |
| R-HSA-9824446 | Viral Infection Pathways | 0.945760 | 0.024 |
| R-HSA-73894 | DNA Repair | 0.948245 | 0.023 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.949456 | 0.023 |
| R-HSA-597592 | Post-translational protein modification | 0.953135 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 0.953716 | 0.021 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.957176 | 0.019 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.959480 | 0.018 |
| R-HSA-8978868 | Fatty acid metabolism | 0.964576 | 0.016 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.968542 | 0.014 |
| R-HSA-5668914 | Diseases of metabolism | 0.969763 | 0.013 |
| R-HSA-168249 | Innate Immune System | 0.981284 | 0.008 |
| R-HSA-5663205 | Infectious disease | 0.981821 | 0.008 |
| R-HSA-168256 | Immune System | 0.987918 | 0.005 |
| R-HSA-392499 | Metabolism of proteins | 0.993455 | 0.003 |
| R-HSA-388396 | GPCR downstream signalling | 0.998123 | 0.001 |
| R-HSA-109582 | Hemostasis | 0.998269 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999044 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999931 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.852 | 0.500 | 1 | 0.803 |
CDK1 |
0.845 | 0.648 | 1 | 0.910 |
CDK18 |
0.845 | 0.655 | 1 | 0.895 |
CDK3 |
0.841 | 0.599 | 1 | 0.895 |
CDK17 |
0.837 | 0.645 | 1 | 0.887 |
CDK19 |
0.837 | 0.592 | 1 | 0.906 |
CDK8 |
0.836 | 0.589 | 1 | 0.908 |
JNK2 |
0.835 | 0.651 | 1 | 0.906 |
KIS |
0.834 | 0.514 | 1 | 0.902 |
CDK7 |
0.833 | 0.600 | 1 | 0.911 |
DYRK2 |
0.832 | 0.547 | 1 | 0.895 |
CDK5 |
0.832 | 0.598 | 1 | 0.898 |
P38G |
0.832 | 0.631 | 1 | 0.892 |
HIPK2 |
0.831 | 0.553 | 1 | 0.895 |
DYRK4 |
0.831 | 0.576 | 1 | 0.914 |
P38B |
0.831 | 0.632 | 1 | 0.901 |
CDK16 |
0.830 | 0.626 | 1 | 0.884 |
JNK3 |
0.830 | 0.633 | 1 | 0.915 |
CDK13 |
0.828 | 0.581 | 1 | 0.907 |
SRPK1 |
0.827 | 0.258 | -3 | 0.582 |
ERK1 |
0.827 | 0.610 | 1 | 0.899 |
CLK2 |
0.826 | 0.346 | -3 | 0.571 |
P38D |
0.825 | 0.619 | 1 | 0.899 |
CDK10 |
0.825 | 0.570 | 1 | 0.894 |
COT |
0.824 | 0.082 | 2 | 0.870 |
NLK |
0.824 | 0.515 | 1 | 0.821 |
CDK14 |
0.824 | 0.603 | 1 | 0.890 |
CDK12 |
0.824 | 0.580 | 1 | 0.907 |
HIPK4 |
0.823 | 0.355 | 1 | 0.799 |
P38A |
0.821 | 0.591 | 1 | 0.889 |
ERK5 |
0.820 | 0.347 | 1 | 0.758 |
MTOR |
0.820 | 0.219 | 1 | 0.662 |
CDK9 |
0.819 | 0.561 | 1 | 0.905 |
HIPK1 |
0.818 | 0.496 | 1 | 0.885 |
CDK2 |
0.817 | 0.475 | 1 | 0.873 |
ERK2 |
0.816 | 0.589 | 1 | 0.895 |
CLK1 |
0.815 | 0.307 | -3 | 0.558 |
DYRK1B |
0.814 | 0.515 | 1 | 0.899 |
NDR2 |
0.814 | 0.092 | -3 | 0.731 |
JNK1 |
0.813 | 0.570 | 1 | 0.904 |
SRPK2 |
0.812 | 0.180 | -3 | 0.505 |
CLK4 |
0.811 | 0.273 | -3 | 0.576 |
ICK |
0.811 | 0.285 | -3 | 0.687 |
CDC7 |
0.809 | -0.024 | 1 | 0.601 |
MOS |
0.808 | 0.052 | 1 | 0.630 |
DYRK1A |
0.807 | 0.407 | 1 | 0.883 |
CDKL1 |
0.806 | 0.095 | -3 | 0.637 |
CDKL5 |
0.806 | 0.124 | -3 | 0.634 |
MAK |
0.806 | 0.431 | -2 | 0.795 |
PIM3 |
0.805 | 0.017 | -3 | 0.697 |
PRPK |
0.805 | -0.069 | -1 | 0.820 |
GRK1 |
0.805 | 0.100 | -2 | 0.737 |
CDK6 |
0.805 | 0.555 | 1 | 0.886 |
CAMK2G |
0.804 | 0.010 | 2 | 0.818 |
CDK4 |
0.803 | 0.564 | 1 | 0.901 |
HIPK3 |
0.802 | 0.444 | 1 | 0.856 |
RSK2 |
0.802 | 0.033 | -3 | 0.611 |
WNK1 |
0.802 | 0.012 | -2 | 0.879 |
DYRK3 |
0.801 | 0.366 | 1 | 0.865 |
ATR |
0.801 | -0.002 | 1 | 0.598 |
SKMLCK |
0.800 | 0.031 | -2 | 0.846 |
SRPK3 |
0.799 | 0.138 | -3 | 0.548 |
CHAK2 |
0.799 | 0.046 | -1 | 0.877 |
CAMK1B |
0.799 | -0.030 | -3 | 0.684 |
NDR1 |
0.799 | 0.005 | -3 | 0.693 |
IKKB |
0.798 | -0.113 | -2 | 0.710 |
MST4 |
0.798 | -0.002 | 2 | 0.784 |
PRKD1 |
0.797 | 0.029 | -3 | 0.700 |
PRKD2 |
0.797 | 0.028 | -3 | 0.625 |
RAF1 |
0.797 | -0.149 | 1 | 0.559 |
PDHK4 |
0.797 | -0.147 | 1 | 0.616 |
RIPK3 |
0.797 | -0.056 | 3 | 0.671 |
PIM1 |
0.796 | 0.028 | -3 | 0.620 |
TBK1 |
0.796 | -0.122 | 1 | 0.487 |
LATS2 |
0.796 | 0.031 | -5 | 0.777 |
PRP4 |
0.796 | 0.300 | -3 | 0.614 |
CAMK2A |
0.795 | 0.071 | 2 | 0.817 |
AURC |
0.795 | 0.061 | -2 | 0.667 |
GSK3A |
0.795 | 0.257 | 4 | 0.539 |
P90RSK |
0.794 | -0.001 | -3 | 0.608 |
PKN2 |
0.794 | -0.031 | -3 | 0.673 |
BMPR2 |
0.794 | -0.185 | -2 | 0.836 |
DSTYK |
0.794 | -0.146 | 2 | 0.852 |
IKKE |
0.793 | -0.130 | 1 | 0.487 |
PKCD |
0.793 | 0.020 | 2 | 0.740 |
GRK5 |
0.793 | -0.090 | -3 | 0.718 |
PKACG |
0.792 | 0.018 | -2 | 0.764 |
LATS1 |
0.792 | 0.143 | -3 | 0.759 |
PKN3 |
0.792 | -0.050 | -3 | 0.668 |
NIK |
0.792 | -0.047 | -3 | 0.719 |
NEK6 |
0.792 | -0.049 | -2 | 0.786 |
CAMK2D |
0.791 | -0.031 | -3 | 0.697 |
CAMLCK |
0.791 | -0.024 | -2 | 0.834 |
RSK3 |
0.791 | -0.021 | -3 | 0.596 |
HUNK |
0.791 | -0.084 | 2 | 0.827 |
ULK2 |
0.790 | -0.185 | 2 | 0.738 |
NUAK2 |
0.790 | -0.030 | -3 | 0.674 |
IKKA |
0.790 | -0.013 | -2 | 0.698 |
RSK4 |
0.790 | 0.042 | -3 | 0.602 |
GCN2 |
0.790 | -0.239 | 2 | 0.757 |
PRKX |
0.789 | 0.069 | -3 | 0.535 |
CAMK2B |
0.788 | 0.020 | 2 | 0.793 |
MNK1 |
0.788 | 0.056 | -2 | 0.808 |
MLK1 |
0.788 | -0.123 | 2 | 0.761 |
PKCG |
0.787 | 0.017 | 2 | 0.696 |
GRK6 |
0.787 | -0.074 | 1 | 0.571 |
DAPK2 |
0.787 | -0.053 | -3 | 0.704 |
NEK7 |
0.786 | -0.158 | -3 | 0.741 |
MLK3 |
0.786 | -0.003 | 2 | 0.686 |
GRK7 |
0.786 | 0.052 | 1 | 0.544 |
MNK2 |
0.786 | 0.026 | -2 | 0.794 |
PKCA |
0.786 | 0.027 | 2 | 0.668 |
P70S6KB |
0.786 | -0.035 | -3 | 0.623 |
PKCB |
0.785 | 0.008 | 2 | 0.677 |
PKACB |
0.785 | 0.030 | -2 | 0.690 |
PDHK1 |
0.785 | -0.232 | 1 | 0.586 |
ULK1 |
0.785 | -0.159 | -3 | 0.689 |
PASK |
0.785 | 0.149 | -3 | 0.735 |
DLK |
0.785 | -0.076 | 1 | 0.576 |
MAPKAPK2 |
0.784 | -0.035 | -3 | 0.597 |
MAPKAPK3 |
0.784 | -0.071 | -3 | 0.636 |
MOK |
0.784 | 0.342 | 1 | 0.821 |
PAK1 |
0.783 | -0.024 | -2 | 0.790 |
IRE1 |
0.783 | -0.072 | 1 | 0.526 |
AMPKA1 |
0.783 | -0.071 | -3 | 0.701 |
DNAPK |
0.782 | 0.019 | 1 | 0.519 |
WNK3 |
0.782 | -0.195 | 1 | 0.541 |
MSK1 |
0.782 | -0.004 | -3 | 0.591 |
RIPK1 |
0.782 | -0.143 | 1 | 0.540 |
MASTL |
0.782 | -0.164 | -2 | 0.779 |
TGFBR2 |
0.782 | -0.129 | -2 | 0.702 |
MLK2 |
0.782 | -0.074 | 2 | 0.749 |
TSSK2 |
0.781 | -0.050 | -5 | 0.830 |
MARK4 |
0.781 | -0.094 | 4 | 0.749 |
BMPR1B |
0.781 | -0.019 | 1 | 0.556 |
PKG2 |
0.781 | 0.028 | -2 | 0.710 |
GSK3B |
0.780 | 0.129 | 4 | 0.531 |
BCKDK |
0.780 | -0.179 | -1 | 0.712 |
PAK3 |
0.780 | -0.060 | -2 | 0.787 |
GRK4 |
0.780 | -0.131 | -2 | 0.764 |
MSK2 |
0.779 | -0.057 | -3 | 0.587 |
TSSK1 |
0.779 | -0.028 | -3 | 0.725 |
ATM |
0.779 | -0.073 | 1 | 0.545 |
SMG1 |
0.779 | -0.037 | 1 | 0.559 |
PKCZ |
0.778 | -0.011 | 2 | 0.714 |
ERK7 |
0.778 | 0.172 | 2 | 0.479 |
AMPKA2 |
0.778 | -0.065 | -3 | 0.672 |
VRK2 |
0.778 | 0.021 | 1 | 0.645 |
NIM1 |
0.777 | -0.105 | 3 | 0.680 |
PKR |
0.777 | -0.053 | 1 | 0.568 |
PRKD3 |
0.776 | -0.043 | -3 | 0.567 |
AURB |
0.776 | -0.004 | -2 | 0.659 |
ANKRD3 |
0.776 | -0.161 | 1 | 0.579 |
SGK3 |
0.776 | -0.009 | -3 | 0.608 |
FAM20C |
0.776 | -0.031 | 2 | 0.586 |
TGFBR1 |
0.776 | -0.053 | -2 | 0.732 |
NEK9 |
0.776 | -0.199 | 2 | 0.775 |
CAMK4 |
0.776 | -0.115 | -3 | 0.659 |
PKCH |
0.776 | -0.041 | 2 | 0.667 |
ALK4 |
0.776 | -0.076 | -2 | 0.762 |
DRAK1 |
0.775 | -0.051 | 1 | 0.538 |
MYLK4 |
0.775 | -0.048 | -2 | 0.764 |
AKT2 |
0.775 | -0.012 | -3 | 0.512 |
MPSK1 |
0.774 | 0.119 | 1 | 0.545 |
IRE2 |
0.774 | -0.081 | 2 | 0.699 |
PAK6 |
0.774 | -0.025 | -2 | 0.692 |
TTBK2 |
0.774 | -0.184 | 2 | 0.677 |
CK1E |
0.773 | -0.028 | -3 | 0.443 |
CHAK1 |
0.772 | -0.097 | 2 | 0.702 |
MEK1 |
0.772 | -0.157 | 2 | 0.799 |
PLK1 |
0.772 | -0.136 | -2 | 0.724 |
MELK |
0.772 | -0.098 | -3 | 0.647 |
MLK4 |
0.772 | -0.096 | 2 | 0.664 |
YSK4 |
0.772 | -0.134 | 1 | 0.516 |
DCAMKL1 |
0.771 | -0.033 | -3 | 0.622 |
NUAK1 |
0.771 | -0.086 | -3 | 0.624 |
PHKG1 |
0.771 | -0.097 | -3 | 0.674 |
MST3 |
0.771 | -0.004 | 2 | 0.784 |
NEK2 |
0.770 | -0.116 | 2 | 0.732 |
GRK2 |
0.769 | -0.066 | -2 | 0.671 |
PINK1 |
0.769 | 0.019 | 1 | 0.685 |
CAMK1G |
0.769 | -0.067 | -3 | 0.580 |
PAK2 |
0.768 | -0.087 | -2 | 0.764 |
PIM2 |
0.768 | -0.025 | -3 | 0.573 |
ACVR2B |
0.768 | -0.098 | -2 | 0.714 |
PKACA |
0.768 | -0.001 | -2 | 0.650 |
PLK3 |
0.767 | -0.109 | 2 | 0.785 |
CHK1 |
0.767 | -0.048 | -3 | 0.709 |
QIK |
0.766 | -0.151 | -3 | 0.682 |
QSK |
0.766 | -0.092 | 4 | 0.714 |
DCAMKL2 |
0.766 | -0.037 | -3 | 0.637 |
AURA |
0.765 | -0.043 | -2 | 0.615 |
PLK4 |
0.765 | -0.074 | 2 | 0.608 |
ALK2 |
0.765 | -0.086 | -2 | 0.731 |
ACVR2A |
0.765 | -0.115 | -2 | 0.699 |
TLK2 |
0.765 | -0.120 | 1 | 0.535 |
CK1D |
0.765 | -0.019 | -3 | 0.407 |
TAO3 |
0.765 | -0.026 | 1 | 0.557 |
PKCE |
0.764 | 0.009 | 2 | 0.677 |
IRAK4 |
0.764 | -0.070 | 1 | 0.515 |
GAK |
0.764 | 0.021 | 1 | 0.574 |
WNK4 |
0.764 | -0.106 | -2 | 0.859 |
MARK3 |
0.763 | -0.080 | 4 | 0.666 |
CK1A2 |
0.763 | -0.027 | -3 | 0.395 |
PKCT |
0.763 | -0.058 | 2 | 0.669 |
MAPKAPK5 |
0.763 | -0.140 | -3 | 0.556 |
SIK |
0.762 | -0.120 | -3 | 0.592 |
SMMLCK |
0.761 | -0.064 | -3 | 0.645 |
MEKK3 |
0.761 | -0.170 | 1 | 0.547 |
MEK5 |
0.761 | -0.180 | 2 | 0.768 |
PKCI |
0.761 | -0.034 | 2 | 0.681 |
AKT1 |
0.761 | -0.033 | -3 | 0.543 |
BRSK1 |
0.761 | -0.127 | -3 | 0.626 |
BUB1 |
0.761 | 0.161 | -5 | 0.758 |
NEK5 |
0.760 | -0.101 | 1 | 0.544 |
ZAK |
0.760 | -0.145 | 1 | 0.535 |
CK1G1 |
0.760 | -0.074 | -3 | 0.427 |
CK2A2 |
0.759 | -0.016 | 1 | 0.522 |
BMPR1A |
0.759 | -0.065 | 1 | 0.538 |
BRAF |
0.759 | -0.153 | -4 | 0.797 |
SSTK |
0.759 | -0.041 | 4 | 0.706 |
NEK11 |
0.758 | -0.101 | 1 | 0.558 |
GCK |
0.758 | 0.003 | 1 | 0.544 |
BRSK2 |
0.757 | -0.156 | -3 | 0.655 |
MEKK1 |
0.757 | -0.182 | 1 | 0.546 |
LKB1 |
0.757 | -0.031 | -3 | 0.725 |
SNRK |
0.757 | -0.217 | 2 | 0.630 |
MEKK2 |
0.756 | -0.161 | 2 | 0.745 |
MARK2 |
0.756 | -0.124 | 4 | 0.630 |
HASPIN |
0.754 | 0.103 | -1 | 0.804 |
PDK1 |
0.754 | -0.071 | 1 | 0.569 |
PHKG2 |
0.754 | -0.121 | -3 | 0.614 |
GRK3 |
0.754 | -0.076 | -2 | 0.620 |
MARK1 |
0.753 | -0.136 | 4 | 0.689 |
P70S6K |
0.753 | -0.091 | -3 | 0.536 |
TAO2 |
0.753 | -0.096 | 2 | 0.792 |
CK2A1 |
0.753 | -0.012 | 1 | 0.510 |
HRI |
0.753 | -0.243 | -2 | 0.782 |
PAK4 |
0.753 | -0.041 | -2 | 0.628 |
AKT3 |
0.753 | -0.018 | -3 | 0.468 |
SGK1 |
0.753 | -0.007 | -3 | 0.450 |
TNIK |
0.752 | -0.021 | 3 | 0.790 |
PAK5 |
0.752 | -0.061 | -2 | 0.623 |
MAP3K15 |
0.752 | -0.044 | 1 | 0.529 |
STK33 |
0.752 | -0.058 | 2 | 0.618 |
CAMKK2 |
0.751 | -0.080 | -2 | 0.714 |
HPK1 |
0.751 | -0.045 | 1 | 0.536 |
DAPK3 |
0.751 | -0.057 | -3 | 0.630 |
PDHK3_TYR |
0.751 | 0.359 | 4 | 0.881 |
CAMKK1 |
0.751 | -0.160 | -2 | 0.710 |
CAMK1D |
0.751 | -0.083 | -3 | 0.521 |
PERK |
0.750 | -0.245 | -2 | 0.749 |
TTBK1 |
0.750 | -0.165 | 2 | 0.624 |
TLK1 |
0.750 | -0.202 | -2 | 0.755 |
ROCK2 |
0.750 | 0.007 | -3 | 0.631 |
LRRK2 |
0.750 | -0.036 | 2 | 0.790 |
EEF2K |
0.750 | -0.061 | 3 | 0.758 |
MEKK6 |
0.750 | -0.103 | 1 | 0.544 |
HGK |
0.749 | -0.066 | 3 | 0.789 |
MRCKA |
0.749 | -0.012 | -3 | 0.588 |
SLK |
0.749 | -0.029 | -2 | 0.693 |
MRCKB |
0.748 | -0.022 | -3 | 0.563 |
NEK8 |
0.748 | -0.187 | 2 | 0.762 |
SBK |
0.748 | 0.023 | -3 | 0.405 |
PLK2 |
0.748 | -0.054 | -3 | 0.638 |
DAPK1 |
0.748 | -0.056 | -3 | 0.606 |
KHS1 |
0.747 | -0.029 | 1 | 0.523 |
PKN1 |
0.747 | -0.084 | -3 | 0.550 |
DMPK1 |
0.746 | 0.025 | -3 | 0.582 |
KHS2 |
0.746 | -0.007 | 1 | 0.539 |
NEK4 |
0.746 | -0.157 | 1 | 0.510 |
LOK |
0.745 | -0.062 | -2 | 0.762 |
MINK |
0.745 | -0.116 | 1 | 0.520 |
IRAK1 |
0.744 | -0.250 | -1 | 0.718 |
TAK1 |
0.744 | -0.134 | 1 | 0.542 |
VRK1 |
0.743 | -0.126 | 2 | 0.829 |
MST2 |
0.743 | -0.144 | 1 | 0.537 |
PBK |
0.743 | -0.036 | 1 | 0.512 |
MST1 |
0.742 | -0.103 | 1 | 0.521 |
NEK1 |
0.742 | -0.125 | 1 | 0.513 |
PDHK4_TYR |
0.741 | 0.202 | 2 | 0.855 |
CHK2 |
0.741 | -0.085 | -3 | 0.457 |
TESK1_TYR |
0.738 | 0.099 | 3 | 0.776 |
LIMK2_TYR |
0.737 | 0.138 | -3 | 0.770 |
YSK1 |
0.736 | -0.119 | 2 | 0.733 |
CAMK1A |
0.736 | -0.088 | -3 | 0.484 |
CRIK |
0.735 | -0.014 | -3 | 0.560 |
MAP2K6_TYR |
0.734 | 0.037 | -1 | 0.810 |
PKMYT1_TYR |
0.734 | 0.064 | 3 | 0.744 |
MAP2K4_TYR |
0.734 | 0.006 | -1 | 0.811 |
BMPR2_TYR |
0.734 | 0.039 | -1 | 0.806 |
YANK3 |
0.733 | -0.031 | 2 | 0.440 |
PKG1 |
0.732 | -0.053 | -2 | 0.642 |
RIPK2 |
0.732 | -0.255 | 1 | 0.497 |
ROCK1 |
0.732 | -0.039 | -3 | 0.579 |
ASK1 |
0.731 | -0.083 | 1 | 0.523 |
MAP2K7_TYR |
0.730 | -0.082 | 2 | 0.825 |
PDHK1_TYR |
0.730 | -0.004 | -1 | 0.819 |
MEK2 |
0.729 | -0.248 | 2 | 0.745 |
CK1A |
0.729 | -0.050 | -3 | 0.324 |
BIKE |
0.729 | -0.031 | 1 | 0.485 |
OSR1 |
0.728 | -0.093 | 2 | 0.729 |
EPHA6 |
0.727 | -0.049 | -1 | 0.784 |
ALPHAK3 |
0.726 | -0.071 | -1 | 0.742 |
PINK1_TYR |
0.725 | -0.159 | 1 | 0.600 |
LIMK1_TYR |
0.724 | -0.044 | 2 | 0.797 |
EPHB4 |
0.724 | -0.063 | -1 | 0.746 |
MYO3B |
0.723 | -0.096 | 2 | 0.737 |
NEK3 |
0.722 | -0.199 | 1 | 0.516 |
MYO3A |
0.721 | -0.098 | 1 | 0.525 |
TAO1 |
0.721 | -0.118 | 1 | 0.496 |
RET |
0.721 | -0.142 | 1 | 0.552 |
TNK2 |
0.721 | -0.016 | 3 | 0.674 |
DDR1 |
0.721 | -0.079 | 4 | 0.811 |
AAK1 |
0.721 | 0.019 | 1 | 0.425 |
TTK |
0.720 | -0.140 | -2 | 0.733 |
TYRO3 |
0.720 | -0.128 | 3 | 0.705 |
TXK |
0.719 | -0.037 | 1 | 0.566 |
CSF1R |
0.719 | -0.103 | 3 | 0.698 |
MST1R |
0.718 | -0.140 | 3 | 0.709 |
EPHA4 |
0.717 | -0.047 | 2 | 0.801 |
JAK2 |
0.716 | -0.137 | 1 | 0.555 |
ABL2 |
0.716 | -0.096 | -1 | 0.746 |
TNK1 |
0.716 | -0.007 | 3 | 0.682 |
YES1 |
0.715 | -0.103 | -1 | 0.772 |
ROS1 |
0.714 | -0.157 | 3 | 0.678 |
JAK3 |
0.714 | -0.130 | 1 | 0.555 |
ABL1 |
0.713 | -0.101 | -1 | 0.736 |
FGFR2 |
0.713 | -0.071 | 3 | 0.706 |
EPHB1 |
0.713 | -0.111 | 1 | 0.563 |
ITK |
0.712 | -0.088 | -1 | 0.722 |
KIT |
0.712 | -0.122 | 3 | 0.700 |
DDR2 |
0.711 | 0.011 | 3 | 0.654 |
TYK2 |
0.711 | -0.260 | 1 | 0.539 |
KDR |
0.711 | -0.093 | 3 | 0.670 |
TEK |
0.710 | -0.068 | 3 | 0.654 |
FGR |
0.710 | -0.165 | 1 | 0.549 |
INSRR |
0.710 | -0.156 | 3 | 0.660 |
SRMS |
0.710 | -0.139 | 1 | 0.558 |
BMX |
0.709 | -0.069 | -1 | 0.684 |
MERTK |
0.709 | -0.109 | 3 | 0.674 |
FER |
0.708 | -0.192 | 1 | 0.576 |
EPHB3 |
0.708 | -0.131 | -1 | 0.721 |
EPHB2 |
0.708 | -0.123 | -1 | 0.714 |
BLK |
0.708 | -0.086 | -1 | 0.753 |
JAK1 |
0.708 | -0.099 | 1 | 0.511 |
LCK |
0.707 | -0.117 | -1 | 0.757 |
WEE1_TYR |
0.707 | -0.076 | -1 | 0.738 |
HCK |
0.707 | -0.163 | -1 | 0.748 |
AXL |
0.707 | -0.132 | 3 | 0.680 |
MET |
0.706 | -0.109 | 3 | 0.692 |
EPHA7 |
0.706 | -0.085 | 2 | 0.789 |
NEK10_TYR |
0.705 | -0.134 | 1 | 0.473 |
TNNI3K_TYR |
0.705 | -0.075 | 1 | 0.572 |
FGFR1 |
0.705 | -0.119 | 3 | 0.662 |
FGFR3 |
0.704 | -0.083 | 3 | 0.681 |
STLK3 |
0.704 | -0.217 | 1 | 0.498 |
YANK2 |
0.704 | -0.046 | 2 | 0.454 |
CK1G3 |
0.703 | -0.066 | -3 | 0.281 |
FLT1 |
0.703 | -0.123 | -1 | 0.744 |
FYN |
0.703 | -0.082 | -1 | 0.743 |
EPHA3 |
0.702 | -0.113 | 2 | 0.766 |
TEC |
0.702 | -0.143 | -1 | 0.676 |
FLT3 |
0.702 | -0.225 | 3 | 0.703 |
PDGFRB |
0.701 | -0.232 | 3 | 0.707 |
PTK2B |
0.700 | -0.084 | -1 | 0.705 |
MATK |
0.698 | -0.098 | -1 | 0.699 |
BTK |
0.698 | -0.224 | -1 | 0.698 |
EPHA1 |
0.697 | -0.163 | 3 | 0.670 |
EPHA5 |
0.696 | -0.115 | 2 | 0.782 |
LTK |
0.695 | -0.186 | 3 | 0.636 |
FLT4 |
0.695 | -0.180 | 3 | 0.657 |
FRK |
0.695 | -0.170 | -1 | 0.750 |
PTK2 |
0.695 | -0.038 | -1 | 0.704 |
ALK |
0.694 | -0.200 | 3 | 0.623 |
ERBB2 |
0.694 | -0.196 | 1 | 0.519 |
PDGFRA |
0.694 | -0.258 | 3 | 0.710 |
EPHA8 |
0.694 | -0.117 | -1 | 0.720 |
CSK |
0.693 | -0.132 | 2 | 0.787 |
NTRK1 |
0.693 | -0.233 | -1 | 0.738 |
LYN |
0.693 | -0.156 | 3 | 0.620 |
EGFR |
0.692 | -0.111 | 1 | 0.459 |
INSR |
0.692 | -0.193 | 3 | 0.636 |
NTRK3 |
0.691 | -0.163 | -1 | 0.701 |
FGFR4 |
0.691 | -0.101 | -1 | 0.698 |
CK1G2 |
0.690 | -0.061 | -3 | 0.360 |
SRC |
0.690 | -0.145 | -1 | 0.736 |
NTRK2 |
0.690 | -0.246 | 3 | 0.664 |
SYK |
0.689 | -0.076 | -1 | 0.700 |
EPHA2 |
0.688 | -0.100 | -1 | 0.691 |
PTK6 |
0.685 | -0.272 | -1 | 0.675 |
ERBB4 |
0.684 | -0.095 | 1 | 0.477 |
MUSK |
0.680 | -0.167 | 1 | 0.439 |
IGF1R |
0.679 | -0.173 | 3 | 0.582 |
ZAP70 |
0.677 | -0.059 | -1 | 0.664 |
FES |
0.668 | -0.159 | -1 | 0.662 |