Motif 167 (n=206)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A0A1W2PPC1 | PRR33 | S207 | ochoa | Proline rich 33 | None |
A7KAX9 | ARHGAP32 | S1720 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
A8MZF0 | PRR33 | S59 | ochoa | Proline-rich protein 33 | None |
O00444 | PLK4 | S589 | ochoa | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
O14641 | DVL2 | S126 | ochoa | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
O14686 | KMT2D | S468 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O14686 | KMT2D | S2251 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
O15047 | SETD1A | S556 | ochoa | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}. |
O15054 | KDM6B | S215 | ochoa | Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}. |
O15117 | FYB1 | S205 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
O15169 | AXIN1 | S493 | ochoa | Axin-1 (Axis inhibition protein 1) (hAxin) | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}. |
O15357 | INPPL1 | S1160 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
O15357 | INPPL1 | S1176 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
O43182 | ARHGAP6 | S711 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
O43294 | TGFB1I1 | S186 | ochoa | Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}. |
O43312 | MTSS1 | S644 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
O43379 | WDR62 | S1388 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
O43516 | WIPF1 | S137 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
O43516 | WIPF1 | S276 | ochoa | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}. |
O60240 | PLIN1 | S458 | ochoa | Perilipin-1 (Lipid droplet-associated protein) | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
O60885 | BRD4 | S1117 | ochoa | Bromodomain-containing protein 4 (Protein HUNK1) | Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
O75083 | WDR1 | S189 | ochoa | WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}. |
O75145 | PPFIA3 | S512 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
O75410 | TACC1 | S248 | ochoa | Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}. |
O94875 | SORBS2 | S186 | ochoa | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}. |
O94989 | ARHGEF15 | S84 | ochoa | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
O95180 | CACNA1H | S44 | ochoa | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}. |
O96028 | NSD2 | S102 | ochoa|psp | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
P04049 | RAF1 | S322 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
P06400 | RB1 | S882 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
P08913 | ADRA2A | S311 | psp | Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}. |
P09017 | HOXC4 | S243 | ochoa | Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
P12980 | LYL1 | S51 | ochoa | Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) | None |
P14317 | HCLS1 | S299 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
P15408 | FOSL2 | S215 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
P17096 | HMGA1 | S44 | ochoa|psp | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
P17600 | SYN1 | S605 | ochoa|psp | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
P19429 | TNNI3 | S23 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
P19971 | TYMP | S23 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
P24821 | TNC | S70 | ochoa | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}. |
P27815 | PDE4A | S830 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
P30304 | CDC25A | S295 | psp | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}. |
P35568 | IRS1 | S303 | ochoa|psp | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
P38159 | RBMX | S173 | ochoa | RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. |
P41162 | ETV3 | S361 | ochoa | ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) | Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}. |
P41212 | ETV6 | S184 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
P43146 | DCC | S1383 | ochoa | Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}. |
P46821 | MAP1B | S1346 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
P48169 | GABRA4 | S446 | ochoa | Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020). {ECO:0000250|UniProtKB:Q9D6F4, ECO:0000269|PubMed:35355020}. |
P51116 | FXR2 | S504 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
P51587 | BRCA2 | S3291 | psp | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
P51608 | MECP2 | S395 | ochoa | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}. |
P52824 | DGKQ | S31 | ochoa | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}. |
P56945 | BCAR1 | S260 | ochoa | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}. |
P61978 | HNRNPK | S302 | psp | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}. |
P78310 | CXADR | S346 | ochoa | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
P78332 | RBM6 | S44 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
P78411 | IRX5 | S246 | ochoa | Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) | Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}. |
P85299 | PRR5 | S309 | ochoa | Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}. |
Q01826 | SATB1 | S637 | ochoa | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
Q03164 | KMT2A | S1854 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q03164 | KMT2A | S2110 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
Q05D60 | DEUP1 | S526 | ochoa | Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}. |
Q08050 | FOXM1 | S499 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
Q08211 | DHX9 | S125 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
Q08495 | DMTN | S105 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
Q0JRZ9 | FCHO2 | S474 | ochoa | F-BAR domain only protein 2 | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
Q13263 | TRIM28 | S453 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
Q13428 | TCOF1 | S153 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
Q13443 | ADAM9 | S798 | ochoa | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}. |
Q14152 | EIF3A | S1028 | ochoa | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
Q14160 | SCRIB | S432 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
Q14517 | FAT1 | S4272 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
Q14694 | USP10 | S78 | ochoa | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}. |
Q14814 | MEF2D | S258 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
Q14839 | CHD4 | S1544 | ochoa | Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}. |
Q14847 | LASP1 | S182 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
Q15021 | NCAPD2 | S1330 | ochoa | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
Q15113 | PCOLCE | S309 | ochoa | Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer) | Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; FUNCTION: C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity. |
Q15652 | JMJD1C | S630 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
Q15942 | ZYX | S505 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
Q16625 | OCLN | S302 | ochoa | Occludin | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}. |
Q32P44 | EML3 | S156 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
Q4ZG55 | GREB1 | S1190 | ochoa | Protein GREB1 (Gene regulated in breast cancer 1 protein) | May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. |
Q5SXM2 | SNAPC4 | S611 | ochoa | snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}. |
Q5T0W9 | FAM83B | S388 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
Q5T0Z8 | C6orf132 | S437 | ochoa | Uncharacterized protein C6orf132 | None |
Q5T5P2 | KIAA1217 | S352 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
Q5T7B8 | KIF24 | S988 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
Q5TC79 | ZBTB37 | S328 | ochoa | Zinc finger and BTB domain-containing protein 37 | May be involved in transcriptional regulation. |
Q5VUB5 | FAM171A1 | S640 | ochoa | Protein FAM171A1 (Astroprincin) (APCN) | Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}. |
Q68DK7 | MSL1 | S401 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
Q6IQ23 | PLEKHA7 | S856 | ochoa | Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) | Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}. |
Q6NUN9 | ZNF746 | S359 | ochoa | Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}. |
Q6NV74 | CRACDL | S640 | ochoa | CRACD-like protein | None |
Q6NZI2 | CAVIN1 | S25 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
Q6UB99 | ANKRD11 | S1859 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6WKZ4 | RAB11FIP1 | S1171 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
Q6ZVH7 | ESPNL | S372 | ochoa | Espin-like protein | Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}. |
Q6ZW31 | SYDE1 | S51 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
Q70E73 | RAPH1 | S983 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
Q765P7 | MTSS2 | S579 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
Q7Z6J6 | FRMD5 | S349 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
Q86SQ0 | PHLDB2 | S562 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86SQ0 | PHLDB2 | S565 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86UW9 | DTX2 | S236 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
Q86UX6 | STK32C | S362 | ochoa | Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) | None |
Q86X51 | EZHIP | S410 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
Q86XK3 | SFR1 | S36 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
Q86YD1 | PTOV1 | S34 | ochoa | Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) | May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}. |
Q86YV5 | PRAG1 | S492 | ochoa | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}. |
Q8IV36 | HID1 | S670 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
Q8IVM0 | CCDC50 | S143 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
Q8IYJ3 | SYTL1 | S216 | ochoa | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
Q8IZP0 | ABI1 | S187 | ochoa | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
Q8N3F8 | MICALL1 | S559 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
Q8N3V7 | SYNPO | S814 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
Q8N4C8 | MINK1 | S732 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
Q8N9U0 | TC2N | S156 | ochoa | Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) | None |
Q8NAX2 | KDF1 | S186 | ochoa | Keratinocyte differentiation factor 1 | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}. |
Q8NDX5 | PHC3 | S676 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
Q8NEF9 | SRFBP1 | S215 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
Q8NEL9 | DDHD1 | S130 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
Q8NEY1 | NAV1 | S652 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
Q8NEZ4 | KMT2C | S1887 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
Q8NFW9 | MYRIP | S298 | ochoa | Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}. |
Q8TE67 | EPS8L3 | S214 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) | None |
Q8TER5 | ARHGEF40 | S262 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
Q8WUA4 | GTF3C2 | S772 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
Q8WUI4 | HDAC7 | S155 | ochoa|psp | Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}. |
Q8WUM9 | SLC20A1 | S318 | ochoa | Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}. |
Q8WUY3 | PRUNE2 | S2180 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
Q8WWI1 | LMO7 | S1537 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
Q8WXE0 | CASKIN2 | S368 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WXE0 | CASKIN2 | Y384 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
Q8WZ73 | RFFL | S30 | ochoa | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}. |
Q92536 | SLC7A6 | S22 | ochoa | Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}. |
Q92610 | ZNF592 | S412 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
Q92945 | KHSRP | S129 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
Q969H4 | CNKSR1 | S305 | ochoa | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | May function as an adapter protein or regulator of Ras signaling pathways. |
Q96B54 | ZNF428 | S99 | ochoa | Zinc finger protein 428 (Enzyme-like protein PIT13) | None |
Q96BH1 | RNF25 | S297 | ochoa | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951216}. |
Q96CP6 | GRAMD1A | S48 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
Q96E39 | RBMXL1 | S173 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
Q96EP0 | RNF31 | S451 | ochoa | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. |
Q96PC5 | MIA2 | S1239 | ochoa | Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}. |
Q96PN7 | TRERF1 | S758 | ochoa | Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) | Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}. |
Q96PU5 | NEDD4L | S365 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
Q96PU5 | NEDD4L | S366 | ochoa | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}. |
Q96RT1 | ERBIN | S1128 | ochoa | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}. |
Q96S53 | TESK2 | S460 | ochoa | Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. |
Q99501 | GAS2L1 | S297 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
Q99759 | MAP3K3 | S168 | ochoa | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
Q9BQE9 | BCL7B | S148 | ochoa | B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) | Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}. |
Q9BTC0 | DIDO1 | S1746 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BW71 | HIRIP3 | S530 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
Q9BWT7 | CARD10 | S551 | ochoa | Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) | Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}. |
Q9BY89 | KIAA1671 | S1775 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BYJ9 | YTHDF1 | S252 | ochoa | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}. |
Q9BYV8 | CEP41 | S282 | ochoa | Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) | Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}. |
Q9BZQ8 | NIBAN1 | S639 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
Q9C0B0 | UNK | S475 | psp | RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) | Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}. |
Q9C0D5 | TANC1 | S1632 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
Q9C0H5 | ARHGAP39 | S285 | ochoa | Rho GTPase-activating protein 39 | None |
Q9H3M7 | TXNIP | S358 | ochoa | Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}. |
Q9H7D0 | DOCK5 | S1830 | ochoa | Dedicator of cytokinesis protein 5 | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}. |
Q9H7N4 | SCAF1 | S552 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
Q9H7P9 | PLEKHG2 | S90 | ochoa | Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
Q9H910 | JPT2 | S30 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
Q9HCD6 | TANC2 | S425 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
Q9HDC5 | JPH1 | S574 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
Q9NP74 | PALMD | S489 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
Q9NPB6 | PARD6A | S282 | ochoa | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}. |
Q9NQ75 | CASS4 | S328 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
Q9NQW6 | ANLN | S54 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
Q9NR12 | PDLIM7 | S260 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
Q9NTZ6 | RBM12 | S415 | ochoa | RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) | None |
Q9NWS9 | ZNF446 | S137 | ochoa | Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) | May be involved in transcriptional regulation. |
Q9NYB9 | ABI2 | S187 | psp | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
Q9NZ52 | GGA3 | S368 | psp | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
Q9NZ52 | GGA3 | S370 | ochoa | ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}. |
Q9P1Z0 | ZBTB4 | S706 | ochoa | Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) | Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}. |
Q9P206 | NHSL3 | S522 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
Q9P270 | SLAIN2 | S234 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
Q9UGP4 | LIMD1 | S323 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
Q9UKD1 | GMEB2 | S379 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
Q9UKG1 | APPL1 | S410 | ochoa|psp | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
Q9ULV3 | CIZ1 | S878 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
Q9UMS6 | SYNPO2 | S595 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UMS6 | SYNPO2 | S768 | ochoa | Synaptopodin-2 (Genethonin-2) (Myopodin) | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. |
Q9UPN4 | CEP131 | S144 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
Q9UPQ9 | TNRC6B | S421 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
Q9UPS6 | SETD1B | S826 | ochoa | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}. |
Q9UQ35 | SRRM2 | S2155 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
Q9UQC2 | GAB2 | Y614 | ochoa|psp | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
Q9Y2F5 | ICE1 | S1474 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
Q9Y2U8 | LEMD3 | S140 | ochoa | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}. |
Q9Y446 | PKP3 | S285 | ochoa|psp | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
Q9Y570 | PPME1 | S25 | ochoa | Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) | Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}. |
Q9Y6K9 | IKBKG | S383 | ochoa | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}. |
P59047 | NLRP5 | S331 | SIGNOR | NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require) | Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. {ECO:0000250|UniProtKB:Q9R1M5}. |
O94776 | MTA2 | S496 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
Q12802 | AKAP13 | S1294 | Sugiyama | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
Q13470 | TNK1 | S354 | Sugiyama | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
Q4KMP7 | TBC1D10B | S28 | Sugiyama | TBC1 domain family member 10B (Rab27A-GAP-beta) | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}. |
Q9NRA0 | SPHK2 | S98 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-3214841 | PKMTs methylate histone lysines | 0.000053 | 4.278 |
R-HSA-9022534 | Loss of MECP2 binding ability to 5hmC-DNA | 0.000349 | 3.458 |
R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.000200 | 3.700 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.000280 | 3.553 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.000610 | 3.214 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.000540 | 3.268 |
R-HSA-4839726 | Chromatin organization | 0.001108 | 2.956 |
R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.002123 | 2.673 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.002399 | 2.620 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.002446 | 2.611 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.002480 | 2.606 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.002422 | 2.616 |
R-HSA-9022927 | MECP2 regulates transcription of genes involved in GABA signaling | 0.003030 | 2.519 |
R-HSA-9675151 | Disorders of Developmental Biology | 0.002948 | 2.530 |
R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.004088 | 2.389 |
R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.004088 | 2.389 |
R-HSA-156711 | Polo-like kinase mediated events | 0.003799 | 2.420 |
R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.004405 | 2.356 |
R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.005293 | 2.276 |
R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005293 | 2.276 |
R-HSA-2559583 | Cellular Senescence | 0.005695 | 2.244 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.005630 | 2.250 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.005630 | 2.250 |
R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.006640 | 2.178 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.007087 | 2.150 |
R-HSA-9022707 | MECP2 regulates transcription factors | 0.008127 | 2.090 |
R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.008127 | 2.090 |
R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.008127 | 2.090 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.011500 | 1.939 |
R-HSA-193648 | NRAGE signals death through JNK | 0.011140 | 1.953 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.011557 | 1.937 |
R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 0.013263 | 1.877 |
R-HSA-5467345 | Deletions in the AXIN1 gene destabilize the destruction complex | 0.013263 | 1.877 |
R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.013380 | 1.874 |
R-HSA-8943724 | Regulation of PTEN gene transcription | 0.013631 | 1.865 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.014815 | 1.829 |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.015862 | 1.800 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.017507 | 1.757 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.017618 | 1.754 |
R-HSA-9697154 | Disorders of Nervous System Development | 0.019747 | 1.705 |
R-HSA-9005895 | Pervasive developmental disorders | 0.019747 | 1.705 |
R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.019747 | 1.705 |
R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.020516 | 1.688 |
R-HSA-5619507 | Activation of HOX genes during differentiation | 0.020516 | 1.688 |
R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.022100 | 1.656 |
R-HSA-69275 | G2/M Transition | 0.021155 | 1.675 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.022155 | 1.655 |
R-HSA-162582 | Signal Transduction | 0.022624 | 1.645 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.024050 | 1.619 |
R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.026351 | 1.579 |
R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.026351 | 1.579 |
R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.027133 | 1.567 |
R-HSA-73887 | Death Receptor Signaling | 0.029011 | 1.537 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.029056 | 1.537 |
R-HSA-5602636 | IKBKB deficiency causes SCID | 0.039267 | 1.406 |
R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.039267 | 1.406 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.052011 | 1.284 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.052011 | 1.284 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.052011 | 1.284 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.052011 | 1.284 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.052011 | 1.284 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.052011 | 1.284 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.052011 | 1.284 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.052011 | 1.284 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.052011 | 1.284 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.052011 | 1.284 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.052011 | 1.284 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.064588 | 1.190 |
R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.064588 | 1.190 |
R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 0.064588 | 1.190 |
R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.064588 | 1.190 |
R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.076998 | 1.114 |
R-HSA-74713 | IRS activation | 0.089245 | 1.049 |
R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.089245 | 1.049 |
R-HSA-9645135 | STAT5 Activation | 0.113255 | 0.946 |
R-HSA-177539 | Autointegration results in viral DNA circles | 0.113255 | 0.946 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 0.125022 | 0.903 |
R-HSA-112412 | SOS-mediated signalling | 0.125022 | 0.903 |
R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.125022 | 0.903 |
R-HSA-8875656 | MET receptor recycling | 0.136635 | 0.864 |
R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.136635 | 0.864 |
R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.136635 | 0.864 |
R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.136635 | 0.864 |
R-HSA-201688 | WNT mediated activation of DVL | 0.148093 | 0.829 |
R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.170559 | 0.768 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.170559 | 0.768 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.170559 | 0.768 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.170559 | 0.768 |
R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.181569 | 0.741 |
R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.181569 | 0.741 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.181569 | 0.741 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.068845 | 1.162 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.192434 | 0.716 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.192434 | 0.716 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.192434 | 0.716 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.192434 | 0.716 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.192434 | 0.716 |
R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.203156 | 0.692 |
R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.203156 | 0.692 |
R-HSA-418885 | DCC mediated attractive signaling | 0.224176 | 0.649 |
R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.224176 | 0.649 |
R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.224176 | 0.649 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.224176 | 0.649 |
R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.234478 | 0.630 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.234478 | 0.630 |
R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.254675 | 0.594 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.063780 | 1.195 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.070577 | 1.151 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.070577 | 1.151 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.274342 | 0.562 |
R-HSA-9656223 | Signaling by RAF1 mutants | 0.139880 | 0.854 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.077686 | 1.110 |
R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.283981 | 0.547 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.283981 | 0.547 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.283981 | 0.547 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.283981 | 0.547 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.283981 | 0.547 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.283981 | 0.547 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.095421 | 1.020 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 0.162966 | 0.788 |
R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.302878 | 0.519 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.302878 | 0.519 |
R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.302878 | 0.519 |
R-HSA-380287 | Centrosome maturation | 0.100768 | 0.997 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.312139 | 0.506 |
R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.321278 | 0.493 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.141270 | 0.850 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.254899 | 0.594 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.084222 | 1.075 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.317603 | 0.498 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.040895 | 1.388 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.040895 | 1.388 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.044771 | 1.349 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.040895 | 1.388 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.072595 | 1.139 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.087630 | 1.057 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.162966 | 0.788 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.162966 | 0.788 |
R-HSA-5674135 | MAP2K and MAPK activation | 0.139880 | 0.854 |
R-HSA-198203 | PI3K/AKT activation | 0.159401 | 0.798 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.234478 | 0.630 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.312139 | 0.506 |
R-HSA-6802949 | Signaling by RAS mutants | 0.162966 | 0.788 |
R-HSA-418886 | Netrin mediated repulsion signals | 0.125022 | 0.903 |
R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.244644 | 0.611 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.113270 | 0.946 |
R-HSA-162592 | Integration of provirus | 0.181569 | 0.741 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.034814 | 1.458 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.113270 | 0.946 |
R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.089245 | 1.049 |
R-HSA-912526 | Interleukin receptor SHC signaling | 0.058006 | 1.237 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.181569 | 0.741 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.213736 | 0.670 |
R-HSA-9664420 | Killing mechanisms | 0.234478 | 0.630 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.234478 | 0.630 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.117608 | 0.930 |
R-HSA-4086400 | PCP/CE pathway | 0.109007 | 0.963 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.068845 | 1.162 |
R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.148093 | 0.829 |
R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.072595 | 1.139 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.279511 | 0.554 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.092266 | 1.035 |
R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.101330 | 0.994 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.038412 | 1.416 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.148093 | 0.829 |
R-HSA-350054 | Notch-HLH transcription pathway | 0.054539 | 1.263 |
R-HSA-4839744 | Signaling by APC mutants | 0.170559 | 0.768 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.181569 | 0.741 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.192434 | 0.716 |
R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.192434 | 0.716 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.203156 | 0.692 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.130862 | 0.883 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 0.274342 | 0.562 |
R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.330296 | 0.481 |
R-HSA-6807070 | PTEN Regulation | 0.059525 | 1.225 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.235242 | 0.628 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.066077 | 1.180 |
R-HSA-112399 | IRS-mediated signalling | 0.215679 | 0.666 |
R-HSA-74749 | Signal attenuation | 0.159401 | 0.798 |
R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.125022 | 0.903 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.054539 | 1.263 |
R-HSA-3214815 | HDACs deacetylate histones | 0.205955 | 0.686 |
R-HSA-74751 | Insulin receptor signalling cascade | 0.249980 | 0.602 |
R-HSA-5357905 | Regulation of TNFR1 signaling | 0.162966 | 0.788 |
R-HSA-9682385 | FLT3 signaling in disease | 0.113270 | 0.946 |
R-HSA-195721 | Signaling by WNT | 0.135774 | 0.867 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.330296 | 0.481 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.264574 | 0.577 |
R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.130862 | 0.883 |
R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.130862 | 0.883 |
R-HSA-2428924 | IGF1R signaling cascade | 0.249980 | 0.602 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.062440 | 1.205 |
R-HSA-75893 | TNF signaling | 0.210812 | 0.676 |
R-HSA-376172 | DSCAM interactions | 0.052011 | 1.284 |
R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.101330 | 0.994 |
R-HSA-175567 | Integration of viral DNA into host genomic DNA | 0.113255 | 0.946 |
R-HSA-164843 | 2-LTR circle formation | 0.159401 | 0.798 |
R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 0.181569 | 0.741 |
R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.224176 | 0.649 |
R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.274342 | 0.562 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.293492 | 0.532 |
R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.293492 | 0.532 |
R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.293492 | 0.532 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.330296 | 0.481 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.126227 | 0.899 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.149834 | 0.824 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.252611 | 0.598 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.254899 | 0.594 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.330296 | 0.481 |
R-HSA-9842663 | Signaling by LTK | 0.192434 | 0.716 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.224176 | 0.649 |
R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.244644 | 0.611 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.269667 | 0.569 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.284430 | 0.546 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.077686 | 1.110 |
R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.038412 | 1.416 |
R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.234478 | 0.630 |
R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.330296 | 0.481 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.114141 | 0.943 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.264574 | 0.577 |
R-HSA-162594 | Early Phase of HIV Life Cycle | 0.293492 | 0.532 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.103486 | 0.985 |
R-HSA-427652 | Sodium-coupled phosphate cotransporters | 0.101330 | 0.994 |
R-HSA-937039 | IRAK1 recruits IKK complex | 0.192434 | 0.716 |
R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.192434 | 0.716 |
R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.213736 | 0.670 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.087630 | 1.057 |
R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.302878 | 0.519 |
R-HSA-429947 | Deadenylation of mRNA | 0.330296 | 0.481 |
R-HSA-68877 | Mitotic Prometaphase | 0.314607 | 0.502 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.249980 | 0.602 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.068845 | 1.162 |
R-HSA-9659379 | Sensory processing of sound | 0.323605 | 0.490 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.148093 | 0.829 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.158294 | 0.801 |
R-HSA-9031628 | NGF-stimulated transcription | 0.039910 | 1.399 |
R-HSA-8854214 | TBC/RABGAPs | 0.031617 | 1.500 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.104725 | 0.980 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.109007 | 0.963 |
R-HSA-2559585 | Oncogene Induced Senescence | 0.108975 | 0.963 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.309359 | 0.510 |
R-HSA-8853659 | RET signaling | 0.113270 | 0.946 |
R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 0.101330 | 0.994 |
R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.170559 | 0.768 |
R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.213736 | 0.670 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.224176 | 0.649 |
R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.293492 | 0.532 |
R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.302878 | 0.519 |
R-HSA-74160 | Gene expression (Transcription) | 0.036161 | 1.442 |
R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.254675 | 0.594 |
R-HSA-9843745 | Adipogenesis | 0.135360 | 0.869 |
R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.101330 | 0.994 |
R-HSA-390696 | Adrenoceptors | 0.136635 | 0.864 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.044610 | 1.351 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.213736 | 0.670 |
R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.234478 | 0.630 |
R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.254675 | 0.594 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.264574 | 0.577 |
R-HSA-844456 | The NLRP3 inflammasome | 0.274342 | 0.562 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.144439 | 0.840 |
R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.092793 | 1.032 |
R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.106232 | 0.974 |
R-HSA-109704 | PI3K Cascade | 0.181887 | 0.740 |
R-HSA-5617833 | Cilium Assembly | 0.305635 | 0.515 |
R-HSA-1640170 | Cell Cycle | 0.179114 | 0.747 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.260755 | 0.584 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.092793 | 1.032 |
R-HSA-5689880 | Ub-specific processing proteases | 0.255509 | 0.593 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.050911 | 1.293 |
R-HSA-212436 | Generic Transcription Pathway | 0.047286 | 1.325 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.158294 | 0.801 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.159401 | 0.798 |
R-HSA-525793 | Myogenesis | 0.068845 | 1.162 |
R-HSA-392517 | Rap1 signalling | 0.274342 | 0.562 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.302878 | 0.519 |
R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.312139 | 0.506 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.087630 | 1.057 |
R-HSA-69206 | G1/S Transition | 0.287821 | 0.541 |
R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.203156 | 0.692 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.143017 | 0.845 |
R-HSA-8939211 | ESR-mediated signaling | 0.131823 | 0.880 |
R-HSA-8983432 | Interleukin-15 signaling | 0.192434 | 0.716 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.126048 | 0.899 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.192434 | 0.716 |
R-HSA-2586552 | Signaling by Leptin | 0.159401 | 0.798 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.144439 | 0.840 |
R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.302878 | 0.519 |
R-HSA-451927 | Interleukin-2 family signaling | 0.130862 | 0.883 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.136635 | 0.864 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.148093 | 0.829 |
R-HSA-391160 | Signal regulatory protein family interactions | 0.213736 | 0.670 |
R-HSA-210991 | Basigin interactions | 0.293492 | 0.532 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.308961 | 0.510 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.259071 | 0.587 |
R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.274342 | 0.562 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.095778 | 1.019 |
R-HSA-1500931 | Cell-Cell communication | 0.293765 | 0.532 |
R-HSA-9007101 | Rab regulation of trafficking | 0.255503 | 0.593 |
R-HSA-166520 | Signaling by NTRKs | 0.183066 | 0.737 |
R-HSA-9671555 | Signaling by PDGFR in disease | 0.302878 | 0.519 |
R-HSA-194138 | Signaling by VEGF | 0.119250 | 0.924 |
R-HSA-2243919 | Crosslinking of collagen fibrils | 0.274342 | 0.562 |
R-HSA-1538133 | G0 and Early G1 | 0.092266 | 1.035 |
R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.096368 | 1.016 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.312139 | 0.506 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.144031 | 0.842 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.113270 | 0.946 |
R-HSA-3000170 | Syndecan interactions | 0.321278 | 0.493 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.237780 | 0.624 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.126406 | 0.898 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.177125 | 0.752 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.321278 | 0.493 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.240150 | 0.620 |
R-HSA-75153 | Apoptotic execution phase | 0.036472 | 1.438 |
R-HSA-9833482 | PKR-mediated signaling | 0.328469 | 0.484 |
R-HSA-109581 | Apoptosis | 0.095150 | 1.022 |
R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 0.203156 | 0.692 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.230340 | 0.638 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.230340 | 0.638 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.230340 | 0.638 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.230340 | 0.638 |
R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 0.254675 | 0.594 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.330296 | 0.481 |
R-HSA-8863678 | Neurodegenerative Diseases | 0.330296 | 0.481 |
R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 0.213736 | 0.670 |
R-HSA-5357801 | Programmed Cell Death | 0.184240 | 0.735 |
R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 0.274342 | 0.562 |
R-HSA-982772 | Growth hormone receptor signaling | 0.321278 | 0.493 |
R-HSA-2028269 | Signaling by Hippo | 0.254675 | 0.594 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.215671 | 0.666 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.230340 | 0.638 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.061133 | 1.214 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.335624 | 0.474 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.339195 | 0.470 |
R-HSA-9839394 | TGFBR3 expression | 0.339195 | 0.470 |
R-HSA-9620244 | Long-term potentiation | 0.339195 | 0.470 |
R-HSA-420029 | Tight junction interactions | 0.339195 | 0.470 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.339195 | 0.470 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.339195 | 0.470 |
R-HSA-3214842 | HDMs demethylate histones | 0.339195 | 0.470 |
R-HSA-1266695 | Interleukin-7 signaling | 0.339195 | 0.470 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.343003 | 0.465 |
R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.347976 | 0.458 |
R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.347976 | 0.458 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.347976 | 0.458 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.347976 | 0.458 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.347976 | 0.458 |
R-HSA-9664417 | Leishmania phagocytosis | 0.349466 | 0.457 |
R-HSA-9664407 | Parasite infection | 0.349466 | 0.457 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.349466 | 0.457 |
R-HSA-72172 | mRNA Splicing | 0.350677 | 0.455 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.352638 | 0.453 |
R-HSA-1500620 | Meiosis | 0.352638 | 0.453 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.352638 | 0.453 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.353089 | 0.452 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.356443 | 0.448 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.356642 | 0.448 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.356642 | 0.448 |
R-HSA-264876 | Insulin processing | 0.356642 | 0.448 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.356642 | 0.448 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.362223 | 0.441 |
R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.365192 | 0.437 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.365192 | 0.437 |
R-HSA-622312 | Inflammasomes | 0.365192 | 0.437 |
R-HSA-73614 | Pyrimidine salvage | 0.365192 | 0.437 |
R-HSA-446728 | Cell junction organization | 0.366969 | 0.435 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.373629 | 0.428 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.373629 | 0.428 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.373629 | 0.428 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.373629 | 0.428 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.373629 | 0.428 |
R-HSA-180024 | DARPP-32 events | 0.373629 | 0.428 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.374770 | 0.426 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.374868 | 0.426 |
R-HSA-9658195 | Leishmania infection | 0.374868 | 0.426 |
R-HSA-112310 | Neurotransmitter release cycle | 0.381231 | 0.419 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.381955 | 0.418 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.381955 | 0.418 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.381955 | 0.418 |
R-HSA-69242 | S Phase | 0.381968 | 0.418 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.389148 | 0.410 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.389148 | 0.410 |
R-HSA-162588 | Budding and maturation of HIV virion | 0.390170 | 0.409 |
R-HSA-5694530 | Cargo concentration in the ER | 0.390170 | 0.409 |
R-HSA-186763 | Downstream signal transduction | 0.390170 | 0.409 |
R-HSA-74752 | Signaling by Insulin receptor | 0.395330 | 0.403 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.398277 | 0.400 |
R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.398277 | 0.400 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.404647 | 0.393 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.406277 | 0.391 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.406277 | 0.391 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 0.406277 | 0.391 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.406277 | 0.391 |
R-HSA-354192 | Integrin signaling | 0.406277 | 0.391 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.406277 | 0.391 |
R-HSA-176187 | Activation of ATR in response to replication stress | 0.406277 | 0.391 |
R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.406277 | 0.391 |
R-HSA-390522 | Striated Muscle Contraction | 0.414170 | 0.383 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.414170 | 0.383 |
R-HSA-5223345 | Miscellaneous transport and binding events | 0.414170 | 0.383 |
R-HSA-114508 | Effects of PIP2 hydrolysis | 0.414170 | 0.383 |
R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.414170 | 0.383 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.418494 | 0.378 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.421960 | 0.375 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.421960 | 0.375 |
R-HSA-5673000 | RAF activation | 0.421960 | 0.375 |
R-HSA-168638 | NOD1/2 Signaling Pathway | 0.421960 | 0.375 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.423074 | 0.374 |
R-HSA-9006936 | Signaling by TGFB family members | 0.424707 | 0.372 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.429646 | 0.367 |
R-HSA-381042 | PERK regulates gene expression | 0.429646 | 0.367 |
R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.429646 | 0.367 |
R-HSA-163560 | Triglyceride catabolism | 0.437230 | 0.359 |
R-HSA-8941326 | RUNX2 regulates bone development | 0.437230 | 0.359 |
R-HSA-69205 | G1/S-Specific Transcription | 0.437230 | 0.359 |
R-HSA-9020702 | Interleukin-1 signaling | 0.441204 | 0.355 |
R-HSA-4641257 | Degradation of AXIN | 0.444714 | 0.352 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.444714 | 0.352 |
R-HSA-4641258 | Degradation of DVL | 0.444714 | 0.352 |
R-HSA-419037 | NCAM1 interactions | 0.444714 | 0.352 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.444714 | 0.352 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.444714 | 0.352 |
R-HSA-68886 | M Phase | 0.451357 | 0.345 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.452099 | 0.345 |
R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.452099 | 0.345 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.454596 | 0.342 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.454596 | 0.342 |
R-HSA-157118 | Signaling by NOTCH | 0.458014 | 0.339 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.459386 | 0.338 |
R-HSA-201556 | Signaling by ALK | 0.459386 | 0.338 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.459386 | 0.338 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.466577 | 0.331 |
R-HSA-5260271 | Diseases of Immune System | 0.466577 | 0.331 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.466577 | 0.331 |
R-HSA-202433 | Generation of second messenger molecules | 0.466577 | 0.331 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.472898 | 0.325 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.473224 | 0.325 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.473224 | 0.325 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.473672 | 0.325 |
R-HSA-9607240 | FLT3 Signaling | 0.473672 | 0.325 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.473672 | 0.325 |
R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.473672 | 0.325 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.473672 | 0.325 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.473672 | 0.325 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.476469 | 0.322 |
R-HSA-2672351 | Stimuli-sensing channels | 0.476502 | 0.322 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.476621 | 0.322 |
R-HSA-5675221 | Negative regulation of MAPK pathway | 0.480674 | 0.318 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 0.480674 | 0.318 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.480674 | 0.318 |
R-HSA-202403 | TCR signaling | 0.485114 | 0.314 |
R-HSA-421270 | Cell-cell junction organization | 0.489771 | 0.310 |
R-HSA-8953897 | Cellular responses to stimuli | 0.492038 | 0.308 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.494400 | 0.306 |
R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.494400 | 0.306 |
R-HSA-73621 | Pyrimidine catabolism | 0.494400 | 0.306 |
R-HSA-373752 | Netrin-1 signaling | 0.501127 | 0.300 |
R-HSA-69236 | G1 Phase | 0.501127 | 0.300 |
R-HSA-69231 | Cyclin D associated events in G1 | 0.501127 | 0.300 |
R-HSA-375280 | Amine ligand-binding receptors | 0.501127 | 0.300 |
R-HSA-5683826 | Surfactant metabolism | 0.501127 | 0.300 |
R-HSA-5688426 | Deubiquitination | 0.501133 | 0.300 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.502074 | 0.299 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.506722 | 0.295 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.507765 | 0.294 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.507765 | 0.294 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.510419 | 0.292 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.514315 | 0.289 |
R-HSA-9675135 | Diseases of DNA repair | 0.514315 | 0.289 |
R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.514315 | 0.289 |
R-HSA-9839373 | Signaling by TGFBR3 | 0.514315 | 0.289 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.514315 | 0.289 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.514315 | 0.289 |
R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.520778 | 0.283 |
R-HSA-5693538 | Homology Directed Repair | 0.526833 | 0.278 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.527156 | 0.278 |
R-HSA-389356 | Co-stimulation by CD28 | 0.527156 | 0.278 |
R-HSA-73893 | DNA Damage Bypass | 0.533449 | 0.273 |
R-HSA-68875 | Mitotic Prophase | 0.534900 | 0.272 |
R-HSA-5683057 | MAPK family signaling cascades | 0.543649 | 0.265 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.545787 | 0.263 |
R-HSA-912446 | Meiotic recombination | 0.545787 | 0.263 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.545787 | 0.263 |
R-HSA-9864848 | Complex IV assembly | 0.545787 | 0.263 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.546824 | 0.262 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.546824 | 0.262 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.548566 | 0.261 |
R-HSA-6794361 | Neurexins and neuroligins | 0.551833 | 0.258 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.551833 | 0.258 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.557799 | 0.254 |
R-HSA-1221632 | Meiotic synapsis | 0.557799 | 0.254 |
R-HSA-445355 | Smooth Muscle Contraction | 0.557799 | 0.254 |
R-HSA-72649 | Translation initiation complex formation | 0.563686 | 0.249 |
R-HSA-69481 | G2/M Checkpoints | 0.566220 | 0.247 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.566809 | 0.247 |
R-HSA-418597 | G alpha (z) signalling events | 0.569495 | 0.245 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.574684 | 0.241 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.575228 | 0.240 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.575228 | 0.240 |
R-HSA-5578775 | Ion homeostasis | 0.575228 | 0.240 |
R-HSA-177929 | Signaling by EGFR | 0.575228 | 0.240 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.575228 | 0.240 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.577570 | 0.238 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.580884 | 0.236 |
R-HSA-1483166 | Synthesis of PA | 0.580884 | 0.236 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.580884 | 0.236 |
R-HSA-1474165 | Reproduction | 0.581304 | 0.236 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.586465 | 0.232 |
R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.586465 | 0.232 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.586465 | 0.232 |
R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.586465 | 0.232 |
R-HSA-9909396 | Circadian clock | 0.588701 | 0.230 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.591972 | 0.228 |
R-HSA-8979227 | Triglyceride metabolism | 0.591972 | 0.228 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.591972 | 0.228 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.591972 | 0.228 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 0.591972 | 0.228 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.592744 | 0.227 |
R-HSA-977443 | GABA receptor activation | 0.597406 | 0.224 |
R-HSA-1227986 | Signaling by ERBB2 | 0.597406 | 0.224 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.597406 | 0.224 |
R-HSA-450294 | MAP kinase activation | 0.602769 | 0.220 |
R-HSA-8956321 | Nucleotide salvage | 0.602769 | 0.220 |
R-HSA-1442490 | Collagen degradation | 0.602769 | 0.220 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.602940 | 0.220 |
R-HSA-375165 | NCAM signaling for neurite out-growth | 0.608060 | 0.216 |
R-HSA-9707616 | Heme signaling | 0.608060 | 0.216 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.608060 | 0.216 |
R-HSA-186797 | Signaling by PDGF | 0.608060 | 0.216 |
R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.608060 | 0.216 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.610348 | 0.214 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.613281 | 0.212 |
R-HSA-8848021 | Signaling by PTK6 | 0.613281 | 0.212 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.613281 | 0.212 |
R-HSA-418990 | Adherens junctions interactions | 0.617262 | 0.210 |
R-HSA-1234174 | Cellular response to hypoxia | 0.623516 | 0.205 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.628574 | 0.202 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.633481 | 0.198 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.633481 | 0.198 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 0.633481 | 0.198 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 0.634421 | 0.198 |
R-HSA-2262752 | Cellular responses to stress | 0.635153 | 0.197 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.638365 | 0.195 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.647939 | 0.188 |
R-HSA-448424 | Interleukin-17 signaling | 0.647939 | 0.188 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.647939 | 0.188 |
R-HSA-3000178 | ECM proteoglycans | 0.652631 | 0.185 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.652631 | 0.185 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.652631 | 0.185 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.657261 | 0.182 |
R-HSA-4086398 | Ca2+ pathway | 0.661829 | 0.179 |
R-HSA-446652 | Interleukin-1 family signaling | 0.663694 | 0.178 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.666337 | 0.176 |
R-HSA-1226099 | Signaling by FGFR in disease | 0.666337 | 0.176 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.666828 | 0.176 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.669938 | 0.174 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.670785 | 0.173 |
R-HSA-1280218 | Adaptive Immune System | 0.672673 | 0.172 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.673746 | 0.172 |
R-HSA-9610379 | HCMV Late Events | 0.679129 | 0.168 |
R-HSA-162587 | HIV Life Cycle | 0.679129 | 0.168 |
R-HSA-216083 | Integrin cell surface interactions | 0.683778 | 0.165 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.692155 | 0.160 |
R-HSA-6806834 | Signaling by MET | 0.692155 | 0.160 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.692155 | 0.160 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.696260 | 0.157 |
R-HSA-977225 | Amyloid fiber formation | 0.696260 | 0.157 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.696260 | 0.157 |
R-HSA-9609646 | HCMV Infection | 0.700519 | 0.155 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.708252 | 0.150 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.712144 | 0.147 |
R-HSA-1266738 | Developmental Biology | 0.712316 | 0.147 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.721999 | 0.141 |
R-HSA-438064 | Post NMDA receptor activation events | 0.723511 | 0.141 |
R-HSA-9645723 | Diseases of programmed cell death | 0.727200 | 0.138 |
R-HSA-1236974 | ER-Phagosome pathway | 0.730840 | 0.136 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.732587 | 0.135 |
R-HSA-202424 | Downstream TCR signaling | 0.734432 | 0.134 |
R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.737976 | 0.132 |
R-HSA-109582 | Hemostasis | 0.751558 | 0.124 |
R-HSA-1474290 | Collagen formation | 0.751687 | 0.124 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.755002 | 0.122 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 0.758272 | 0.120 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 0.761499 | 0.118 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.761499 | 0.118 |
R-HSA-983712 | Ion channel transport | 0.766991 | 0.115 |
R-HSA-8957275 | Post-translational protein phosphorylation | 0.767826 | 0.115 |
R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.767826 | 0.115 |
R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.767826 | 0.115 |
R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.767826 | 0.115 |
R-HSA-422356 | Regulation of insulin secretion | 0.767826 | 0.115 |
R-HSA-3214847 | HATs acetylate histones | 0.770926 | 0.113 |
R-HSA-9614085 | FOXO-mediated transcription | 0.770926 | 0.113 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.779981 | 0.108 |
R-HSA-1483255 | PI Metabolism | 0.779981 | 0.108 |
R-HSA-9609690 | HCMV Early Events | 0.782711 | 0.106 |
R-HSA-112316 | Neuronal System | 0.783845 | 0.106 |
R-HSA-111885 | Opioid Signalling | 0.785820 | 0.105 |
R-HSA-9833110 | RSV-host interactions | 0.788681 | 0.103 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.791504 | 0.102 |
R-HSA-1643685 | Disease | 0.792840 | 0.101 |
R-HSA-211000 | Gene Silencing by RNA | 0.797038 | 0.099 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.797497 | 0.098 |
R-HSA-376176 | Signaling by ROBO receptors | 0.797497 | 0.098 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.799749 | 0.097 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.799749 | 0.097 |
R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.799749 | 0.097 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.799749 | 0.097 |
R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.802425 | 0.096 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.805065 | 0.094 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.805065 | 0.094 |
R-HSA-6803157 | Antimicrobial peptides | 0.807670 | 0.093 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.810241 | 0.091 |
R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.812777 | 0.090 |
R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.812777 | 0.090 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.817080 | 0.088 |
R-HSA-397014 | Muscle contraction | 0.817080 | 0.088 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.817749 | 0.087 |
R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.820185 | 0.086 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.824961 | 0.084 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.824961 | 0.084 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.827301 | 0.082 |
R-HSA-2980736 | Peptide hormone metabolism | 0.827301 | 0.082 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.831889 | 0.080 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.831889 | 0.080 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.831889 | 0.080 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.838544 | 0.076 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.838544 | 0.076 |
R-HSA-6809371 | Formation of the cornified envelope | 0.842834 | 0.074 |
R-HSA-162909 | Host Interactions of HIV factors | 0.842834 | 0.074 |
R-HSA-162906 | HIV Infection | 0.843296 | 0.074 |
R-HSA-1474244 | Extracellular matrix organization | 0.849311 | 0.071 |
R-HSA-114608 | Platelet degranulation | 0.851077 | 0.070 |
R-HSA-8956319 | Nucleotide catabolism | 0.855036 | 0.068 |
R-HSA-202733 | Cell surface interactions at the vascular wall | 0.858837 | 0.066 |
R-HSA-5576891 | Cardiac conduction | 0.860779 | 0.065 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.862642 | 0.064 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.864481 | 0.063 |
R-HSA-163685 | Integration of energy metabolism | 0.871593 | 0.060 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.873313 | 0.059 |
R-HSA-422475 | Axon guidance | 0.876518 | 0.057 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 0.876683 | 0.057 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.883158 | 0.054 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.883158 | 0.054 |
R-HSA-73894 | DNA Repair | 0.884347 | 0.053 |
R-HSA-199991 | Membrane Trafficking | 0.885295 | 0.053 |
R-HSA-9679506 | SARS-CoV Infections | 0.885659 | 0.053 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.886267 | 0.052 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.886997 | 0.052 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 0.890778 | 0.050 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.892241 | 0.050 |
R-HSA-9758941 | Gastrulation | 0.893685 | 0.049 |
R-HSA-9711123 | Cellular response to chemical stress | 0.898500 | 0.046 |
R-HSA-9824446 | Viral Infection Pathways | 0.905006 | 0.043 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.905845 | 0.043 |
R-HSA-877300 | Interferon gamma signaling | 0.907107 | 0.042 |
R-HSA-9675108 | Nervous system development | 0.907510 | 0.042 |
R-HSA-913531 | Interferon Signaling | 0.907672 | 0.042 |
R-HSA-388396 | GPCR downstream signalling | 0.909701 | 0.041 |
R-HSA-418555 | G alpha (s) signalling events | 0.922065 | 0.035 |
R-HSA-1483257 | Phospholipid metabolism | 0.924352 | 0.034 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.926166 | 0.033 |
R-HSA-611105 | Respiratory electron transport | 0.929099 | 0.032 |
R-HSA-449147 | Signaling by Interleukins | 0.934843 | 0.029 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.940529 | 0.027 |
R-HSA-428157 | Sphingolipid metabolism | 0.948056 | 0.023 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.948755 | 0.023 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.949444 | 0.023 |
R-HSA-372790 | Signaling by GPCR | 0.951157 | 0.022 |
R-HSA-6805567 | Keratinization | 0.952109 | 0.021 |
R-HSA-168249 | Innate Immune System | 0.952866 | 0.021 |
R-HSA-5663205 | Infectious disease | 0.954146 | 0.020 |
R-HSA-68882 | Mitotic Anaphase | 0.958176 | 0.019 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.958633 | 0.018 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.958739 | 0.018 |
R-HSA-8951664 | Neddylation | 0.960916 | 0.017 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.964455 | 0.016 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.964933 | 0.016 |
R-HSA-5653656 | Vesicle-mediated transport | 0.967332 | 0.014 |
R-HSA-15869 | Metabolism of nucleotides | 0.968110 | 0.014 |
R-HSA-8953854 | Metabolism of RNA | 0.974027 | 0.011 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.976438 | 0.010 |
R-HSA-416476 | G alpha (q) signalling events | 0.978196 | 0.010 |
R-HSA-418594 | G alpha (i) signalling events | 0.979027 | 0.009 |
R-HSA-168256 | Immune System | 0.986320 | 0.006 |
R-HSA-6798695 | Neutrophil degranulation | 0.988363 | 0.005 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.992010 | 0.003 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.992363 | 0.003 |
R-HSA-597592 | Post-translational protein modification | 0.995752 | 0.002 |
R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.996352 | 0.002 |
R-HSA-446203 | Asparagine N-linked glycosylation | 0.997515 | 0.001 |
R-HSA-382551 | Transport of small molecules | 0.997722 | 0.001 |
R-HSA-72766 | Translation | 0.997743 | 0.001 |
R-HSA-500792 | GPCR ligand binding | 0.999752 | 0.000 |
R-HSA-392499 | Metabolism of proteins | 0.999777 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 0.999999 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
R-HSA-1430728 | Metabolism | 1.000000 | -0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
CLK3 |
0.880 | 0.403 | 1 | 0.846 |
COT |
0.875 | 0.278 | 2 | 0.896 |
PIM3 |
0.869 | 0.297 | -3 | 0.877 |
RSK2 |
0.869 | 0.313 | -3 | 0.834 |
NDR2 |
0.866 | 0.244 | -3 | 0.884 |
CLK2 |
0.865 | 0.401 | -3 | 0.811 |
SRPK1 |
0.864 | 0.275 | -3 | 0.811 |
P90RSK |
0.861 | 0.267 | -3 | 0.837 |
HIPK4 |
0.861 | 0.291 | 1 | 0.833 |
SKMLCK |
0.858 | 0.301 | -2 | 0.883 |
PIM1 |
0.858 | 0.277 | -3 | 0.825 |
PRKD1 |
0.857 | 0.230 | -3 | 0.874 |
RSK4 |
0.857 | 0.308 | -3 | 0.824 |
MTOR |
0.856 | 0.128 | 1 | 0.783 |
MOS |
0.855 | 0.154 | 1 | 0.823 |
CDC7 |
0.855 | 0.082 | 1 | 0.798 |
CDKL1 |
0.855 | 0.222 | -3 | 0.841 |
RSK3 |
0.855 | 0.236 | -3 | 0.825 |
PRKD2 |
0.855 | 0.227 | -3 | 0.835 |
DYRK2 |
0.854 | 0.298 | 1 | 0.792 |
NDR1 |
0.854 | 0.189 | -3 | 0.868 |
NLK |
0.853 | 0.203 | 1 | 0.866 |
CDKL5 |
0.853 | 0.216 | -3 | 0.840 |
MAPKAPK2 |
0.852 | 0.211 | -3 | 0.797 |
AURC |
0.852 | 0.250 | -2 | 0.712 |
SRPK2 |
0.852 | 0.235 | -3 | 0.744 |
CAMK1B |
0.852 | 0.172 | -3 | 0.867 |
GRK1 |
0.852 | 0.190 | -2 | 0.810 |
CLK4 |
0.851 | 0.300 | -3 | 0.811 |
ICK |
0.851 | 0.263 | -3 | 0.873 |
PKACB |
0.851 | 0.278 | -2 | 0.721 |
ERK5 |
0.850 | 0.166 | 1 | 0.840 |
PRPK |
0.850 | -0.016 | -1 | 0.843 |
CAMK2D |
0.849 | 0.169 | -3 | 0.856 |
P70S6KB |
0.849 | 0.210 | -3 | 0.832 |
IKKB |
0.848 | -0.015 | -2 | 0.739 |
CAMK2A |
0.848 | 0.227 | 2 | 0.855 |
HIPK2 |
0.848 | 0.301 | 1 | 0.722 |
ATR |
0.848 | 0.096 | 1 | 0.825 |
PKACG |
0.848 | 0.198 | -2 | 0.777 |
CAMLCK |
0.848 | 0.212 | -2 | 0.873 |
CAMK2B |
0.848 | 0.205 | 2 | 0.841 |
CLK1 |
0.847 | 0.287 | -3 | 0.797 |
PRKX |
0.847 | 0.280 | -3 | 0.758 |
DSTYK |
0.847 | 0.025 | 2 | 0.922 |
MSK1 |
0.846 | 0.252 | -3 | 0.797 |
LATS2 |
0.846 | 0.122 | -5 | 0.730 |
KIS |
0.846 | 0.168 | 1 | 0.774 |
RAF1 |
0.846 | -0.008 | 1 | 0.799 |
CAMK2G |
0.846 | 0.024 | 2 | 0.850 |
MAPKAPK3 |
0.846 | 0.157 | -3 | 0.826 |
DYRK4 |
0.846 | 0.302 | 1 | 0.731 |
PKN3 |
0.845 | 0.107 | -3 | 0.857 |
DAPK2 |
0.845 | 0.214 | -3 | 0.875 |
SRPK3 |
0.844 | 0.194 | -3 | 0.775 |
HIPK1 |
0.844 | 0.306 | 1 | 0.804 |
MST4 |
0.844 | 0.110 | 2 | 0.870 |
MSK2 |
0.844 | 0.188 | -3 | 0.794 |
WNK1 |
0.844 | 0.098 | -2 | 0.880 |
GCN2 |
0.843 | -0.111 | 2 | 0.810 |
PKCD |
0.843 | 0.172 | 2 | 0.802 |
JNK2 |
0.843 | 0.262 | 1 | 0.722 |
NUAK2 |
0.842 | 0.113 | -3 | 0.869 |
PAK1 |
0.842 | 0.180 | -2 | 0.823 |
PDHK4 |
0.842 | -0.167 | 1 | 0.818 |
PKN2 |
0.842 | 0.120 | -3 | 0.847 |
NIK |
0.841 | 0.119 | -3 | 0.869 |
LATS1 |
0.841 | 0.236 | -3 | 0.902 |
CDK18 |
0.841 | 0.243 | 1 | 0.715 |
NEK6 |
0.841 | 0.030 | -2 | 0.848 |
TBK1 |
0.841 | -0.083 | 1 | 0.698 |
BMPR2 |
0.841 | -0.089 | -2 | 0.877 |
TGFBR2 |
0.840 | 0.047 | -2 | 0.818 |
CDK7 |
0.840 | 0.192 | 1 | 0.765 |
CDK8 |
0.840 | 0.164 | 1 | 0.757 |
IKKE |
0.839 | -0.079 | 1 | 0.694 |
ULK2 |
0.838 | -0.110 | 2 | 0.780 |
CDK19 |
0.838 | 0.178 | 1 | 0.728 |
MARK4 |
0.838 | 0.046 | 4 | 0.741 |
MNK2 |
0.838 | 0.174 | -2 | 0.820 |
RIPK3 |
0.838 | -0.006 | 3 | 0.751 |
GRK5 |
0.838 | -0.046 | -3 | 0.790 |
AKT2 |
0.838 | 0.231 | -3 | 0.756 |
JNK3 |
0.837 | 0.226 | 1 | 0.743 |
CDK1 |
0.837 | 0.202 | 1 | 0.741 |
IKKA |
0.837 | 0.020 | -2 | 0.728 |
FAM20C |
0.837 | 0.119 | 2 | 0.682 |
BMPR1B |
0.836 | 0.178 | 1 | 0.780 |
GRK6 |
0.836 | 0.045 | 1 | 0.803 |
GRK7 |
0.836 | 0.166 | 1 | 0.750 |
PKCA |
0.836 | 0.171 | 2 | 0.747 |
PIM2 |
0.836 | 0.235 | -3 | 0.798 |
TGFBR1 |
0.836 | 0.161 | -2 | 0.824 |
AURB |
0.836 | 0.188 | -2 | 0.711 |
AMPKA1 |
0.836 | 0.084 | -3 | 0.872 |
PAK3 |
0.836 | 0.127 | -2 | 0.816 |
PKG2 |
0.835 | 0.194 | -2 | 0.717 |
PAK6 |
0.835 | 0.185 | -2 | 0.756 |
MNK1 |
0.835 | 0.172 | -2 | 0.828 |
PKCB |
0.834 | 0.136 | 2 | 0.756 |
DYRK3 |
0.834 | 0.285 | 1 | 0.802 |
CDK5 |
0.834 | 0.205 | 1 | 0.782 |
NEK7 |
0.834 | -0.099 | -3 | 0.820 |
SGK3 |
0.834 | 0.215 | -3 | 0.809 |
PKCG |
0.834 | 0.131 | 2 | 0.763 |
PDHK1 |
0.834 | -0.201 | 1 | 0.800 |
CDK13 |
0.834 | 0.166 | 1 | 0.742 |
HUNK |
0.834 | -0.062 | 2 | 0.828 |
ATM |
0.833 | 0.049 | 1 | 0.766 |
CHAK2 |
0.833 | -0.020 | -1 | 0.797 |
MYLK4 |
0.833 | 0.174 | -2 | 0.806 |
PRKD3 |
0.833 | 0.144 | -3 | 0.800 |
MAK |
0.833 | 0.348 | -2 | 0.766 |
DNAPK |
0.833 | 0.142 | 1 | 0.712 |
P38A |
0.833 | 0.206 | 1 | 0.790 |
AMPKA2 |
0.832 | 0.103 | -3 | 0.857 |
DYRK1A |
0.832 | 0.235 | 1 | 0.798 |
P38B |
0.832 | 0.218 | 1 | 0.736 |
MASTL |
0.832 | -0.096 | -2 | 0.815 |
DYRK1B |
0.832 | 0.248 | 1 | 0.754 |
ALK4 |
0.832 | 0.106 | -2 | 0.853 |
BCKDK |
0.832 | -0.108 | -1 | 0.791 |
PKACA |
0.832 | 0.226 | -2 | 0.673 |
MLK1 |
0.831 | -0.097 | 2 | 0.830 |
AURA |
0.831 | 0.164 | -2 | 0.689 |
GSK3A |
0.831 | 0.227 | 4 | 0.570 |
P38G |
0.830 | 0.205 | 1 | 0.666 |
HIPK3 |
0.830 | 0.239 | 1 | 0.788 |
CDK12 |
0.829 | 0.178 | 1 | 0.719 |
NIM1 |
0.829 | 0.043 | 3 | 0.772 |
CDK17 |
0.829 | 0.199 | 1 | 0.670 |
CDK14 |
0.829 | 0.234 | 1 | 0.754 |
TSSK1 |
0.829 | 0.076 | -3 | 0.895 |
CDK10 |
0.829 | 0.245 | 1 | 0.742 |
CDK3 |
0.829 | 0.196 | 1 | 0.688 |
MLK2 |
0.829 | -0.011 | 2 | 0.828 |
NEK9 |
0.828 | -0.086 | 2 | 0.837 |
TSSK2 |
0.828 | 0.033 | -5 | 0.824 |
GRK4 |
0.827 | -0.088 | -2 | 0.822 |
DLK |
0.827 | -0.078 | 1 | 0.796 |
CAMK4 |
0.827 | 0.026 | -3 | 0.835 |
ERK1 |
0.827 | 0.182 | 1 | 0.727 |
MLK3 |
0.827 | 0.012 | 2 | 0.768 |
RIPK1 |
0.827 | -0.076 | 1 | 0.773 |
QSK |
0.827 | 0.076 | 4 | 0.708 |
CDK9 |
0.827 | 0.151 | 1 | 0.747 |
PAK2 |
0.826 | 0.095 | -2 | 0.811 |
PKR |
0.826 | 0.061 | 1 | 0.803 |
PLK1 |
0.825 | -0.007 | -2 | 0.799 |
ULK1 |
0.825 | -0.180 | -3 | 0.772 |
PASK |
0.825 | 0.215 | -3 | 0.888 |
PKCZ |
0.825 | 0.071 | 2 | 0.786 |
DCAMKL1 |
0.824 | 0.152 | -3 | 0.836 |
ANKRD3 |
0.824 | -0.104 | 1 | 0.816 |
ALK2 |
0.824 | 0.093 | -2 | 0.831 |
GSK3B |
0.824 | 0.163 | 4 | 0.562 |
MELK |
0.824 | 0.056 | -3 | 0.842 |
PKCH |
0.824 | 0.077 | 2 | 0.734 |
AKT1 |
0.823 | 0.207 | -3 | 0.775 |
WNK3 |
0.823 | -0.212 | 1 | 0.770 |
BRSK1 |
0.823 | 0.046 | -3 | 0.832 |
DRAK1 |
0.822 | 0.080 | 1 | 0.755 |
SIK |
0.822 | 0.071 | -3 | 0.799 |
CDK16 |
0.822 | 0.208 | 1 | 0.685 |
PHKG1 |
0.822 | 0.021 | -3 | 0.853 |
VRK2 |
0.821 | -0.012 | 1 | 0.845 |
SMG1 |
0.821 | 0.006 | 1 | 0.784 |
ACVR2B |
0.821 | 0.057 | -2 | 0.810 |
TTBK2 |
0.821 | -0.151 | 2 | 0.717 |
IRE1 |
0.820 | -0.076 | 1 | 0.759 |
CHK1 |
0.820 | 0.056 | -3 | 0.856 |
ACVR2A |
0.820 | 0.042 | -2 | 0.799 |
QIK |
0.820 | -0.022 | -3 | 0.843 |
MARK3 |
0.820 | 0.032 | 4 | 0.659 |
NEK2 |
0.819 | -0.035 | 2 | 0.812 |
YSK4 |
0.819 | -0.073 | 1 | 0.738 |
MPSK1 |
0.819 | 0.216 | 1 | 0.789 |
MOK |
0.819 | 0.293 | 1 | 0.814 |
PRP4 |
0.819 | 0.116 | -3 | 0.748 |
CAMK1G |
0.819 | 0.085 | -3 | 0.802 |
TLK2 |
0.819 | -0.005 | 1 | 0.769 |
P70S6K |
0.819 | 0.146 | -3 | 0.760 |
SGK1 |
0.818 | 0.234 | -3 | 0.690 |
MEK1 |
0.818 | -0.109 | 2 | 0.855 |
P38D |
0.818 | 0.194 | 1 | 0.679 |
PLK3 |
0.818 | -0.044 | 2 | 0.805 |
SMMLCK |
0.818 | 0.144 | -3 | 0.840 |
NUAK1 |
0.818 | 0.008 | -3 | 0.831 |
ERK2 |
0.818 | 0.127 | 1 | 0.759 |
AKT3 |
0.817 | 0.226 | -3 | 0.711 |
MAPKAPK5 |
0.817 | 0.009 | -3 | 0.766 |
CDK2 |
0.817 | 0.068 | 1 | 0.801 |
JNK1 |
0.816 | 0.185 | 1 | 0.710 |
MST3 |
0.816 | 0.092 | 2 | 0.859 |
DAPK3 |
0.816 | 0.205 | -3 | 0.840 |
MLK4 |
0.816 | -0.069 | 2 | 0.737 |
BRSK2 |
0.816 | -0.025 | -3 | 0.837 |
PAK4 |
0.816 | 0.155 | -2 | 0.710 |
BMPR1A |
0.814 | 0.099 | 1 | 0.747 |
PAK5 |
0.814 | 0.132 | -2 | 0.706 |
GRK2 |
0.814 | -0.019 | -2 | 0.710 |
IRE2 |
0.813 | -0.073 | 2 | 0.729 |
MARK2 |
0.813 | -0.019 | 4 | 0.624 |
CAMK1D |
0.813 | 0.137 | -3 | 0.748 |
PKCT |
0.812 | 0.084 | 2 | 0.739 |
BRAF |
0.812 | -0.038 | -4 | 0.823 |
DCAMKL2 |
0.812 | 0.057 | -3 | 0.848 |
DAPK1 |
0.812 | 0.197 | -3 | 0.821 |
PKCE |
0.811 | 0.135 | 2 | 0.744 |
TAO3 |
0.811 | 0.040 | 1 | 0.767 |
NEK5 |
0.810 | -0.002 | 1 | 0.793 |
WNK4 |
0.810 | -0.029 | -2 | 0.876 |
PERK |
0.809 | -0.093 | -2 | 0.839 |
MARK1 |
0.809 | -0.027 | 4 | 0.676 |
ROCK2 |
0.809 | 0.229 | -3 | 0.828 |
PLK4 |
0.809 | -0.071 | 2 | 0.625 |
CHAK1 |
0.808 | -0.166 | 2 | 0.771 |
MRCKB |
0.808 | 0.196 | -3 | 0.783 |
GAK |
0.808 | 0.130 | 1 | 0.846 |
MEK5 |
0.808 | -0.163 | 2 | 0.830 |
MEKK1 |
0.808 | -0.112 | 1 | 0.773 |
SBK |
0.807 | 0.189 | -3 | 0.659 |
PKCI |
0.807 | 0.064 | 2 | 0.753 |
MRCKA |
0.807 | 0.185 | -3 | 0.797 |
CK2A2 |
0.807 | 0.089 | 1 | 0.682 |
CK1E |
0.807 | -0.052 | -3 | 0.470 |
LKB1 |
0.806 | 0.076 | -3 | 0.820 |
SNRK |
0.806 | -0.138 | 2 | 0.668 |
MEKK3 |
0.806 | -0.144 | 1 | 0.775 |
GCK |
0.806 | 0.100 | 1 | 0.783 |
ZAK |
0.806 | -0.122 | 1 | 0.740 |
MEKK2 |
0.805 | -0.102 | 2 | 0.806 |
HRI |
0.804 | -0.185 | -2 | 0.843 |
ERK7 |
0.804 | 0.067 | 2 | 0.562 |
CDK4 |
0.804 | 0.163 | 1 | 0.711 |
DMPK1 |
0.803 | 0.240 | -3 | 0.804 |
PINK1 |
0.803 | -0.150 | 1 | 0.834 |
TLK1 |
0.803 | -0.119 | -2 | 0.821 |
GRK3 |
0.803 | -0.018 | -2 | 0.675 |
CDK6 |
0.802 | 0.146 | 1 | 0.731 |
IRAK4 |
0.802 | -0.080 | 1 | 0.756 |
CHK2 |
0.802 | 0.123 | -3 | 0.706 |
SSTK |
0.801 | -0.012 | 4 | 0.689 |
PHKG2 |
0.801 | -0.020 | -3 | 0.821 |
HPK1 |
0.800 | 0.077 | 1 | 0.771 |
BUB1 |
0.800 | 0.179 | -5 | 0.789 |
PDK1 |
0.799 | -0.008 | 1 | 0.738 |
TNIK |
0.799 | 0.064 | 3 | 0.841 |
CAMKK1 |
0.799 | -0.090 | -2 | 0.759 |
CAMKK2 |
0.799 | -0.029 | -2 | 0.758 |
CK2A1 |
0.799 | 0.092 | 1 | 0.665 |
PKN1 |
0.799 | 0.072 | -3 | 0.775 |
TAO2 |
0.798 | -0.059 | 2 | 0.857 |
NEK11 |
0.798 | -0.122 | 1 | 0.759 |
CK1D |
0.798 | -0.051 | -3 | 0.414 |
CAMK1A |
0.797 | 0.118 | -3 | 0.723 |
CRIK |
0.797 | 0.215 | -3 | 0.778 |
CK1G1 |
0.796 | -0.087 | -3 | 0.458 |
NEK8 |
0.795 | -0.138 | 2 | 0.817 |
CK1A2 |
0.795 | -0.056 | -3 | 0.417 |
KHS2 |
0.795 | 0.103 | 1 | 0.773 |
NEK4 |
0.795 | -0.059 | 1 | 0.759 |
PBK |
0.795 | 0.126 | 1 | 0.775 |
PDHK3_TYR |
0.795 | 0.412 | 4 | 0.854 |
KHS1 |
0.795 | 0.078 | 1 | 0.753 |
HGK |
0.794 | -0.017 | 3 | 0.837 |
NEK1 |
0.794 | 0.020 | 1 | 0.760 |
PLK2 |
0.794 | -0.019 | -3 | 0.728 |
LRRK2 |
0.793 | -0.047 | 2 | 0.850 |
MST2 |
0.793 | -0.073 | 1 | 0.780 |
LOK |
0.792 | -0.002 | -2 | 0.775 |
MEKK6 |
0.792 | -0.057 | 1 | 0.765 |
TAK1 |
0.792 | -0.047 | 1 | 0.777 |
EEF2K |
0.792 | -0.044 | 3 | 0.802 |
ROCK1 |
0.792 | 0.180 | -3 | 0.793 |
MINK |
0.792 | -0.037 | 1 | 0.759 |
MAP3K15 |
0.792 | -0.044 | 1 | 0.725 |
TTBK1 |
0.791 | -0.193 | 2 | 0.634 |
VRK1 |
0.790 | -0.063 | 2 | 0.833 |
PKG1 |
0.788 | 0.100 | -2 | 0.641 |
STK33 |
0.787 | -0.106 | 2 | 0.640 |
SLK |
0.787 | -0.053 | -2 | 0.724 |
IRAK1 |
0.785 | -0.287 | -1 | 0.733 |
PDHK4_TYR |
0.785 | 0.208 | 2 | 0.900 |
MST1 |
0.784 | -0.102 | 1 | 0.759 |
YSK1 |
0.784 | -0.038 | 2 | 0.811 |
HASPIN |
0.783 | 0.071 | -1 | 0.725 |
MAP2K4_TYR |
0.782 | 0.132 | -1 | 0.860 |
TESK1_TYR |
0.782 | 0.103 | 3 | 0.872 |
MAP2K6_TYR |
0.781 | 0.116 | -1 | 0.853 |
LIMK2_TYR |
0.780 | 0.170 | -3 | 0.879 |
PKMYT1_TYR |
0.779 | 0.101 | 3 | 0.846 |
MEK2 |
0.779 | -0.212 | 2 | 0.808 |
BIKE |
0.778 | 0.096 | 1 | 0.754 |
BMPR2_TYR |
0.777 | 0.065 | -1 | 0.844 |
MAP2K7_TYR |
0.776 | -0.039 | 2 | 0.870 |
OSR1 |
0.776 | -0.068 | 2 | 0.806 |
YANK3 |
0.775 | -0.042 | 2 | 0.435 |
PDHK1_TYR |
0.774 | -0.000 | -1 | 0.859 |
MYO3B |
0.774 | -0.006 | 2 | 0.822 |
NEK3 |
0.773 | -0.122 | 1 | 0.715 |
RIPK2 |
0.773 | -0.277 | 1 | 0.693 |
TTK |
0.773 | -0.054 | -2 | 0.820 |
EPHA6 |
0.770 | 0.035 | -1 | 0.822 |
PINK1_TYR |
0.770 | -0.130 | 1 | 0.803 |
EPHB4 |
0.769 | 0.029 | -1 | 0.806 |
ASK1 |
0.769 | -0.112 | 1 | 0.711 |
AAK1 |
0.768 | 0.152 | 1 | 0.670 |
RET |
0.767 | -0.071 | 1 | 0.765 |
TAO1 |
0.766 | -0.085 | 1 | 0.687 |
TXK |
0.765 | 0.098 | 1 | 0.805 |
LIMK1_TYR |
0.765 | -0.098 | 2 | 0.850 |
TNK2 |
0.765 | 0.057 | 3 | 0.757 |
MYO3A |
0.764 | -0.089 | 1 | 0.754 |
CK1A |
0.764 | -0.060 | -3 | 0.323 |
ABL2 |
0.763 | 0.003 | -1 | 0.790 |
MST1R |
0.763 | -0.118 | 3 | 0.799 |
DDR1 |
0.761 | -0.109 | 4 | 0.758 |
FGR |
0.761 | -0.052 | 1 | 0.829 |
EPHA4 |
0.761 | -0.009 | 2 | 0.816 |
ALPHAK3 |
0.761 | -0.121 | -1 | 0.736 |
YES1 |
0.760 | -0.038 | -1 | 0.826 |
TYRO3 |
0.759 | -0.126 | 3 | 0.779 |
SRMS |
0.759 | -0.011 | 1 | 0.808 |
ROS1 |
0.759 | -0.122 | 3 | 0.755 |
ABL1 |
0.758 | -0.029 | -1 | 0.785 |
TYK2 |
0.758 | -0.212 | 1 | 0.757 |
JAK2 |
0.757 | -0.158 | 1 | 0.752 |
CSF1R |
0.757 | -0.125 | 3 | 0.772 |
EPHB1 |
0.756 | -0.054 | 1 | 0.800 |
ITK |
0.756 | -0.023 | -1 | 0.768 |
EPHB3 |
0.755 | -0.051 | -1 | 0.792 |
BLK |
0.755 | 0.024 | -1 | 0.808 |
TNK1 |
0.755 | -0.012 | 3 | 0.767 |
FER |
0.754 | -0.158 | 1 | 0.823 |
INSRR |
0.754 | -0.114 | 3 | 0.737 |
LCK |
0.754 | -0.012 | -1 | 0.802 |
JAK3 |
0.754 | -0.152 | 1 | 0.738 |
EPHB2 |
0.753 | -0.052 | -1 | 0.786 |
FGFR2 |
0.753 | -0.129 | 3 | 0.789 |
HCK |
0.753 | -0.094 | -1 | 0.801 |
NEK10_TYR |
0.752 | -0.089 | 1 | 0.645 |
MERTK |
0.752 | -0.048 | 3 | 0.767 |
BMX |
0.752 | -0.018 | -1 | 0.703 |
TNNI3K_TYR |
0.751 | -0.033 | 1 | 0.772 |
DDR2 |
0.751 | 0.037 | 3 | 0.724 |
KDR |
0.750 | -0.103 | 3 | 0.741 |
JAK1 |
0.750 | -0.060 | 1 | 0.700 |
AXL |
0.750 | -0.098 | 3 | 0.766 |
EPHA7 |
0.750 | -0.038 | 2 | 0.806 |
FYN |
0.749 | 0.007 | -1 | 0.783 |
STLK3 |
0.749 | -0.230 | 1 | 0.713 |
KIT |
0.748 | -0.164 | 3 | 0.771 |
PDGFRB |
0.747 | -0.204 | 3 | 0.784 |
MET |
0.747 | -0.116 | 3 | 0.775 |
TEK |
0.746 | -0.161 | 3 | 0.717 |
PTK2B |
0.746 | -0.009 | -1 | 0.759 |
EPHA3 |
0.746 | -0.103 | 2 | 0.780 |
TEC |
0.745 | -0.092 | -1 | 0.717 |
WEE1_TYR |
0.745 | -0.103 | -1 | 0.734 |
FGFR1 |
0.743 | -0.198 | 3 | 0.753 |
LTK |
0.743 | -0.143 | 3 | 0.723 |
NTRK1 |
0.742 | -0.194 | -1 | 0.794 |
EPHA1 |
0.742 | -0.110 | 3 | 0.750 |
EPHA5 |
0.741 | -0.061 | 2 | 0.799 |
FLT3 |
0.741 | -0.250 | 3 | 0.771 |
FGFR3 |
0.741 | -0.154 | 3 | 0.760 |
FLT1 |
0.741 | -0.149 | -1 | 0.788 |
BTK |
0.741 | -0.218 | -1 | 0.743 |
ALK |
0.741 | -0.179 | 3 | 0.698 |
PTK6 |
0.738 | -0.230 | -1 | 0.707 |
ERBB2 |
0.738 | -0.199 | 1 | 0.721 |
PDGFRA |
0.738 | -0.279 | 3 | 0.781 |
LYN |
0.738 | -0.118 | 3 | 0.701 |
PTK2 |
0.737 | 0.009 | -1 | 0.736 |
NTRK3 |
0.737 | -0.146 | -1 | 0.754 |
EPHA8 |
0.737 | -0.088 | -1 | 0.773 |
FRK |
0.736 | -0.153 | -1 | 0.810 |
SRC |
0.736 | -0.085 | -1 | 0.787 |
INSR |
0.736 | -0.196 | 3 | 0.718 |
MATK |
0.736 | -0.135 | -1 | 0.723 |
YANK2 |
0.734 | -0.100 | 2 | 0.454 |
NTRK2 |
0.734 | -0.257 | 3 | 0.743 |
FLT4 |
0.734 | -0.226 | 3 | 0.741 |
EGFR |
0.733 | -0.113 | 1 | 0.634 |
CK1G3 |
0.732 | -0.115 | -3 | 0.277 |
SYK |
0.731 | -0.034 | -1 | 0.735 |
CSK |
0.731 | -0.163 | 2 | 0.802 |
EPHA2 |
0.730 | -0.074 | -1 | 0.739 |
FGFR4 |
0.729 | -0.134 | -1 | 0.743 |
ERBB4 |
0.723 | -0.086 | 1 | 0.667 |
CK1G2 |
0.721 | -0.093 | -3 | 0.373 |
IGF1R |
0.721 | -0.190 | 3 | 0.657 |
MUSK |
0.719 | -0.190 | 1 | 0.634 |
ZAP70 |
0.708 | -0.075 | -1 | 0.668 |
FES |
0.707 | -0.177 | -1 | 0.684 |