Motif 167 (n=206)

Position-wise Probabilities

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uniprot genes site source protein function
A0A1W2PPC1 PRR33 S207 ochoa Proline rich 33 None
A7KAX9 ARHGAP32 S1720 ochoa Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.
A8MZF0 PRR33 S59 ochoa Proline-rich protein 33 None
O00444 PLK4 S589 ochoa Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
O14641 DVL2 S126 ochoa Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}.
O14686 KMT2D S468 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O14686 KMT2D S2251 ochoa Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}.
O15047 SETD1A S556 ochoa Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:12670868, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:29937342, PubMed:31197650, PubMed:32346159). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) (PubMed:31197650). Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation (PubMed:29937342, PubMed:32346159). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). Binds RNAs involved in RNA processing and the DNA damage response (PubMed:38003223). {ECO:0000250|UniProtKB:E9PYH6, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:25561738, ECO:0000269|PubMed:29937342, ECO:0000269|PubMed:31197650, ECO:0000269|PubMed:32346159, ECO:0000269|PubMed:38003223}.
O15054 KDM6B S215 ochoa Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B) Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). {ECO:0000250|UniProtKB:Q5NCY0, ECO:0000269|PubMed:17713478, ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:17851529, ECO:0000269|PubMed:18003914, ECO:0000269|PubMed:28262558}.
O15117 FYB1 S205 ochoa FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}.
O15169 AXIN1 S493 ochoa Axin-1 (Axis inhibition protein 1) (hAxin) Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453, PubMed:28829046). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453, ECO:0000269|PubMed:28546513}.
O15357 INPPL1 S1160 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.
O15357 INPPL1 S1176 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.
O43182 ARHGAP6 S711 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43294 TGFB1I1 S186 ochoa Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5) Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
O43312 MTSS1 S644 ochoa Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
O43379 WDR62 S1388 ochoa WD repeat-containing protein 62 Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.
O43516 WIPF1 S137 ochoa WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
O43516 WIPF1 S276 ochoa WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
O60240 PLIN1 S458 ochoa Perilipin-1 (Lipid droplet-associated protein) Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}.
O60885 BRD4 S1117 ochoa Bromodomain-containing protein 4 (Protein HUNK1) Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:22334664, PubMed:23317504, PubMed:23589332). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:16109376, PubMed:16109377, PubMed:19596240, PubMed:23589332, PubMed:24360279). Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000250|UniProtKB:Q9ESU6, ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:29176719}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}.
O75083 WDR1 S189 ochoa WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). {ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2, ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608, ECO:0000269|PubMed:25792565, ECO:0000269|PubMed:27557945, ECO:0000269|PubMed:29751004}.
O75145 PPFIA3 S512 ochoa Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}.
O75410 TACC1 S248 ochoa Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.
O94875 SORBS2 S186 ochoa Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin) Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
O94989 ARHGEF15 S84 ochoa Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF) Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.
O95180 CACNA1H S44 ochoa Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.
O96028 NSD2 S102 ochoa|psp Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}.
P04049 RAF1 S322 ochoa RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}.
P06400 RB1 S882 ochoa|psp Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}.
P08913 ADRA2A S311 psp Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.
P09017 HOXC4 S243 ochoa Homeobox protein Hox-C4 (Homeobox protein CP19) (Homeobox protein Hox-3E) Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P12980 LYL1 S51 ochoa Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1) None
P14317 HCLS1 S299 ochoa Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
P15408 FOSL2 S215 ochoa Fos-related antigen 2 (FRA-2) Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}.
P17096 HMGA1 S44 ochoa|psp High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
P17600 SYN1 S605 ochoa|psp Synapsin-1 (Brain protein 4.1) (Synapsin I) Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}.
P19429 TNNI3 S23 psp Troponin I, cardiac muscle (Cardiac troponin I) Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
P19971 TYMP S23 ochoa Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}.
P24821 TNC S70 ochoa Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). {ECO:0000269|PubMed:19884327}.
P27815 PDE4A S830 ochoa 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
P30304 CDC25A S295 psp M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (PubMed:20360007). {ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P35568 IRS1 S303 ochoa|psp Insulin receptor substrate 1 (IRS-1) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}.
P38159 RBMX S173 ochoa RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:16707624, ECO:0000269|PubMed:18445477, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}.
P41162 ETV3 S361 ochoa ETS translocation variant 3 (ETS domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor) Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.
P41212 ETV6 S184 ochoa Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.
P43146 DCC S1383 ochoa Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}.
P46821 MAP1B S1346 ochoa Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}.
P48169 GABRA4 S446 ochoa Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020). {ECO:0000250|UniProtKB:Q9D6F4, ECO:0000269|PubMed:35355020}.
P51116 FXR2 S504 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P51587 BRCA2 S3291 psp Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P51608 MECP2 S395 ochoa Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000250|UniProtKB:Q9Z2D6}.
P52824 DGKQ S31 ochoa Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta) Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}.
P56945 BCAR1 S260 ochoa Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}.
P61978 HNRNPK S302 psp Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269|PubMed:16360036, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33174841}.
P78310 CXADR S346 ochoa Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}.
P78332 RBM6 S44 ochoa RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) Specifically binds poly(G) RNA homopolymers in vitro.
P78411 IRX5 S246 ochoa Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5) Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}.
P85299 PRR5 S309 ochoa Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive (PubMed:17461779, PubMed:17599906, PubMed:29424687). mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:17461779, PubMed:17599906, PubMed:29424687). PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling (PubMed:17599906). May act as a tumor suppressor in breast cancer (PubMed:15718101). {ECO:0000269|PubMed:15718101, ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:17599906, ECO:0000269|PubMed:29424687}.
Q01826 SATB1 S637 ochoa DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}.
Q03164 KMT2A S1854 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q03164 KMT2A S2110 ochoa Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.
Q05D60 DEUP1 S526 ochoa Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}.
Q08050 FOXM1 S499 ochoa Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}.
Q08211 DHX9 S125 ochoa ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}.
Q08495 DMTN S105 ochoa Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.
Q0JRZ9 FCHO2 S474 ochoa F-BAR domain only protein 2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Q13263 TRIM28 S453 ochoa Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}.
Q13428 TCOF1 S153 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13443 ADAM9 S798 ochoa Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269|PubMed:12054541}.
Q14152 EIF3A S1028 ochoa Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:11169732, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). {ECO:0000269|PubMed:23766293, ECO:0000269|PubMed:24357634}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
Q14160 SCRIB S432 ochoa Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}.
Q14517 FAT1 S4272 ochoa Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.
Q14694 USP10 S78 ochoa Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR (PubMed:11439350, PubMed:18632802, PubMed:31981475). Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53 (PubMed:20096447). Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response (PubMed:20096447). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13 (PubMed:21962518). Does not deubiquitinate MDM2 (PubMed:20096447). Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits (PubMed:27022092, PubMed:31981475, PubMed:34348161, PubMed:34469731). Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules (PubMed:11439350, PubMed:27022092, PubMed:32302570). Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome (PubMed:31981475, PubMed:34348161, PubMed:34469731). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731). Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling (PubMed:19398555). Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384). Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation (PubMed:37582970). {ECO:0000269|PubMed:11439350, ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:31981475, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:34348161, ECO:0000269|PubMed:34469731, ECO:0000269|PubMed:37582970}.
Q14814 MEF2D S258 ochoa Myocyte-specific enhancer factor 2D Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.
Q14839 CHD4 S1544 ochoa Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:32543371, ECO:0000269|PubMed:9804427}.
Q14847 LASP1 S182 ochoa LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.
Q15021 NCAPD2 S1330 ochoa Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15113 PCOLCE S309 ochoa Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer) Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; FUNCTION: C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
Q15652 JMJD1C S630 ochoa Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.
Q15942 ZYX S505 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16625 OCLN S302 ochoa Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q32P44 EML3 S156 ochoa Echinoderm microtubule-associated protein-like 3 (EMAP-3) Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.
Q4ZG55 GREB1 S1190 ochoa Protein GREB1 (Gene regulated in breast cancer 1 protein) May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
Q5SXM2 SNAPC4 S611 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5T0W9 FAM83B S388 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q5T0Z8 C6orf132 S437 ochoa Uncharacterized protein C6orf132 None
Q5T5P2 KIAA1217 S352 ochoa Sickle tail protein homolog Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}.
Q5T7B8 KIF24 S988 ochoa Kinesin-like protein KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.
Q5TC79 ZBTB37 S328 ochoa Zinc finger and BTB domain-containing protein 37 May be involved in transcriptional regulation.
Q5VUB5 FAM171A1 S640 ochoa Protein FAM171A1 (Astroprincin) (APCN) Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269|PubMed:30312582}.
Q68DK7 MSL1 S401 ochoa Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}.
Q6IQ23 PLEKHA7 S856 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6NUN9 ZNF746 S359 ochoa Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. {ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:31856708}.
Q6NV74 CRACDL S640 ochoa CRACD-like protein None
Q6NZI2 CAVIN1 S25 ochoa Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
Q6UB99 ANKRD11 S1859 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6WKZ4 RAB11FIP1 S1171 ochoa Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}.
Q6ZVH7 ESPNL S372 ochoa Espin-like protein Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. {ECO:0000250|UniProtKB:Q3UYR4}.
Q6ZW31 SYDE1 S51 ochoa Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}.
Q70E73 RAPH1 S983 ochoa Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
Q765P7 MTSS2 S579 ochoa Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.
Q7Z6J6 FRMD5 S349 ochoa FERM domain-containing protein 5 May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).
Q86SQ0 PHLDB2 S562 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86SQ0 PHLDB2 S565 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86UW9 DTX2 S236 ochoa Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Q86UX6 STK32C S362 ochoa Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) None
Q86X51 EZHIP S410 ochoa EZH inhibitory protein Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
Q86XK3 SFR1 S36 ochoa Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}.
Q86YD1 PTOV1 S34 ochoa Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2) May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. {ECO:0000269|PubMed:12598323, ECO:0000269|PubMed:15713644, ECO:0000269|PubMed:17641689}.
Q86YV5 PRAG1 S492 ochoa Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250|UniProtKB:D3ZMK9, ECO:0000250|UniProtKB:Q571I4}.
Q8IV36 HID1 S670 ochoa Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}.
Q8IVM0 CCDC50 S143 ochoa Coiled-coil domain-containing protein 50 (Protein Ymer) Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}.
Q8IYJ3 SYTL1 S216 ochoa Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}.
Q8IZP0 ABI1 S187 ochoa Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
Q8N3F8 MICALL1 S559 ochoa MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}.
Q8N3V7 SYNPO S814 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N4C8 MINK1 S732 ochoa Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Q8N9U0 TC2N S156 ochoa Tandem C2 domains nuclear protein (Membrane targeting tandem C2 domain-containing protein 1) (Tandem C2 protein in nucleus) (Tac2-N) None
Q8NAX2 KDF1 S186 ochoa Keratinocyte differentiation factor 1 Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). {ECO:0000250|UniProtKB:A2A9F4}.
Q8NDX5 PHC3 S676 ochoa Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.
Q8NEF9 SRFBP1 S215 ochoa Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.
Q8NEL9 DDHD1 S130 ochoa Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}.
Q8NEY1 NAV1 S652 ochoa Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) May be involved in neuronal migration. {ECO:0000250}.
Q8NEZ4 KMT2C S1887 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NFW9 MYRIP S298 ochoa Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
Q8TE67 EPS8L3 S214 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) None
Q8TER5 ARHGEF40 S262 ochoa Rho guanine nucleotide exchange factor 40 (Protein SOLO) May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Q8WUA4 GTF3C2 S772 ochoa General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
Q8WUI4 HDAC7 S155 ochoa|psp Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}.
Q8WUM9 SLC20A1 S318 ochoa Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.
Q8WUY3 PRUNE2 S2180 ochoa Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}.
Q8WWI1 LMO7 S1537 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WXE0 CASKIN2 S368 ochoa Caskin-2 (CASK-interacting protein 2) None
Q8WXE0 CASKIN2 Y384 ochoa Caskin-2 (CASK-interacting protein 2) None
Q8WZ73 RFFL S30 ochoa E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:15069192, ECO:0000269|PubMed:17121812, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:18450452, ECO:0000269|PubMed:22609986}.
Q92536 SLC7A6 S22 ochoa Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:17329401, PubMed:19562367, PubMed:31705628, PubMed:9829974). Also exchanges L-arginine with L-lysine in a sodium-independent manner (PubMed:10903140). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10903140). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (PubMed:17197568). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). {ECO:0000250|UniProtKB:D3ZMM8, ECO:0000250|UniProtKB:Q8BGK6, ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:19562367, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974}.
Q92610 ZNF592 S412 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92945 KHSRP S129 ochoa Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Q969H4 CNKSR1 S305 ochoa Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) May function as an adapter protein or regulator of Ras signaling pathways.
Q96B54 ZNF428 S99 ochoa Zinc finger protein 428 (Enzyme-like protein PIT13) None
Q96BH1 RNF25 S297 ochoa E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951216}.
Q96CP6 GRAMD1A S48 ochoa Protein Aster-A (GRAM domain-containing protein 1A) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}.
Q96E39 RBMXL1 S173 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96EP0 RNF31 S451 ochoa E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684, PubMed:28481331). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}.
Q96PC5 MIA2 S1239 ochoa Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11) Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}.
Q96PN7 TRERF1 S758 ochoa Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.
Q96PU5 NEDD4L S365 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96PU5 NEDD4L S366 ochoa E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961, ECO:0000269|PubMed:33608556}.
Q96RT1 ERBIN S1128 ochoa Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.
Q96S53 TESK2 S460 ochoa Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
Q99501 GAS2L1 S297 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99759 MAP3K3 S168 ochoa Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}.
Q9BQE9 BCL7B S148 ochoa B-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3) Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.
Q9BTC0 DIDO1 S1746 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BW71 HIRIP3 S530 ochoa HIRA-interacting protein 3 Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}.
Q9BWT7 CARD10 S551 ochoa Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3) Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR. {ECO:0000269|PubMed:27991920}.
Q9BY89 KIAA1671 S1775 ochoa Uncharacterized protein KIAA1671 None
Q9BYJ9 YTHDF1 S252 ochoa YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability (PubMed:24284625, PubMed:26318451, PubMed:32492408, PubMed:39900921). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (PubMed:24284625, PubMed:32492408). Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex (PubMed:32492408). The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation (PubMed:28106072, PubMed:32492408). Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation (PubMed:31292544, PubMed:31388144, PubMed:32451507). The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules (PubMed:31292544). {ECO:0000250|UniProtKB:P59326, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:28106072, ECO:0000269|PubMed:31292544, ECO:0000269|PubMed:31388144, ECO:0000269|PubMed:32451507, ECO:0000269|PubMed:32492408, ECO:0000269|PubMed:39900921}.
Q9BYV8 CEP41 S282 ochoa Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. {ECO:0000269|PubMed:22246503}.
Q9BZQ8 NIBAN1 S639 ochoa Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9C0B0 UNK S475 psp RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.
Q9C0D5 TANC1 S1632 ochoa Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9C0H5 ARHGAP39 S285 ochoa Rho GTPase-activating protein 39 None
Q9H3M7 TXNIP S358 ochoa Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Q9H7D0 DOCK5 S1830 ochoa Dedicator of cytokinesis protein 5 Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.
Q9H7N4 SCAF1 S552 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9 PLEKHG2 S90 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9H910 JPT2 S30 ochoa Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}.
Q9HCD6 TANC2 S425 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9HDC5 JPH1 S574 ochoa Junctophilin-1 (JP-1) (Junctophilin type 1) Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Q9NP74 PALMD S489 ochoa Palmdelphin (Paralemmin-like protein) None
Q9NPB6 PARD6A S282 ochoa Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.
Q9NQ75 CASS4 S328 ochoa Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.
Q9NQW6 ANLN S54 ochoa Anillin Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}.
Q9NR12 PDLIM7 S260 ochoa PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.
Q9NTZ6 RBM12 S415 ochoa RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) None
Q9NWS9 ZNF446 S137 ochoa Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20) May be involved in transcriptional regulation.
Q9NYB9 ABI2 S187 psp Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
Q9NZ52 GGA3 S368 psp ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.
Q9NZ52 GGA3 S370 ochoa ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3) Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A0A0G2JV04, ECO:0000269|PubMed:11301005, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:17553422, ECO:0000269|PubMed:20484053, ECO:0000269|PubMed:26811329}.
Q9P1Z0 ZBTB4 S706 ochoa Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1) Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity). {ECO:0000250|UniProtKB:Q5F293, ECO:0000269|PubMed:16354688}.
Q9P206 NHSL3 S522 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P270 SLAIN2 S234 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UGP4 LIMD1 S323 ochoa LIM domain-containing protein 1 Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}.
Q9UKD1 GMEB2 S379 ochoa Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Q9UKG1 APPL1 S410 ochoa|psp DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}.
Q9ULV3 CIZ1 S878 ochoa Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) May regulate the subcellular localization of CIP/WAF1.
Q9UMS6 SYNPO2 S595 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UMS6 SYNPO2 S768 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UPN4 CEP131 S144 ochoa Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}.
Q9UPQ9 TNRC6B S421 ochoa Trinucleotide repeat-containing gene 6B protein Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}.
Q9UPS6 SETD1B S826 ochoa Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17355966, PubMed:25561738). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8CFT2, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:25561738}.
Q9UQ35 SRRM2 S2155 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQC2 GAB2 Y614 ochoa|psp GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y2F5 ICE1 S1474 ochoa Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.
Q9Y2U8 LEMD3 S140 ochoa Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Q9Y446 PKP3 S285 ochoa|psp Plakophilin-3 A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}.
Q9Y570 PPME1 S25 ochoa Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. {ECO:0000269|PubMed:10318862}.
Q9Y6K9 IKBKG S383 ochoa NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308, PubMed:33567255). Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin (PubMed:16547522, PubMed:18287044, PubMed:19033441, PubMed:19185524, PubMed:21606507, PubMed:27777308). Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3 (PubMed:19854139). Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (PubMed:20724660). {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:16547522, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:19033441, ECO:0000269|PubMed:19185524, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:33567255, ECO:0000269|PubMed:9751060}.; FUNCTION: (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B. {ECO:0000269|PubMed:10364167, ECO:0000269|PubMed:11064457}.
P59047 NLRP5 S331 SIGNOR NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require) Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. {ECO:0000250|UniProtKB:Q9R1M5}.
O94776 MTA2 S496 Sugiyama Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
Q12802 AKAP13 S1294 Sugiyama A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q13470 TNK1 S354 Sugiyama Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}.
Q4KMP7 TBC1D10B S28 Sugiyama TBC1 domain family member 10B (Rab27A-GAP-beta) Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. {ECO:0000269|PubMed:16923811, ECO:0000269|PubMed:19077034}.
Q9NRA0 SPHK2 S98 Sugiyama Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}.
Download
reactome_id name p -log10_p
R-HSA-3214841 PKMTs methylate histone lysines 0.000053 4.278
R-HSA-9022534 Loss of MECP2 binding ability to 5hmC-DNA 0.000349 3.458
R-HSA-9022692 Regulation of MECP2 expression and activity 0.000200 3.700
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.000280 3.553
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.000610 3.214
R-HSA-8878171 Transcriptional regulation by RUNX1 0.000540 3.268
R-HSA-4839726 Chromatin organization 0.001108 2.956
R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 0.002123 2.673
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.002399 2.620
R-HSA-212165 Epigenetic regulation of gene expression 0.002446 2.611
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.002480 2.606
R-HSA-3247509 Chromatin modifying enzymes 0.002422 2.616
R-HSA-9022927 MECP2 regulates transcription of genes involved in GABA signaling 0.003030 2.519
R-HSA-9675151 Disorders of Developmental Biology 0.002948 2.530
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.004088 2.389
R-HSA-9022535 Loss of phosphorylation of MECP2 at T308 0.004088 2.389
R-HSA-156711 Polo-like kinase mediated events 0.003799 2.420
R-HSA-2559580 Oxidative Stress Induced Senescence 0.004405 2.356
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.005293 2.276
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.005293 2.276
R-HSA-2559583 Cellular Senescence 0.005695 2.244
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.005630 2.250
R-HSA-9700206 Signaling by ALK in cancer 0.005630 2.250
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.006640 2.178
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 0.007087 2.150
R-HSA-9022707 MECP2 regulates transcription factors 0.008127 2.090
R-HSA-9031528 NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... 0.008127 2.090
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.008127 2.090
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.011500 1.939
R-HSA-193648 NRAGE signals death through JNK 0.011140 1.953
R-HSA-8986944 Transcriptional Regulation by MECP2 0.011557 1.937
R-HSA-9661070 Defective translocation of RB1 mutants to the nucleus 0.013263 1.877
R-HSA-5467345 Deletions in the AXIN1 gene destabilize the destruction complex 0.013263 1.877
R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 0.013380 1.874
R-HSA-8943724 Regulation of PTEN gene transcription 0.013631 1.865
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.014815 1.829
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.015862 1.800
R-HSA-4839735 Signaling by AXIN mutants 0.017507 1.757
R-HSA-9018519 Estrogen-dependent gene expression 0.017618 1.754
R-HSA-9697154 Disorders of Nervous System Development 0.019747 1.705
R-HSA-9005895 Pervasive developmental disorders 0.019747 1.705
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.019747 1.705
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.020516 1.688
R-HSA-5619507 Activation of HOX genes during differentiation 0.020516 1.688
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.022100 1.656
R-HSA-69275 G2/M Transition 0.021155 1.675
R-HSA-453274 Mitotic G2-G2/M phases 0.022155 1.655
R-HSA-162582 Signal Transduction 0.022624 1.645
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.024050 1.619
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.026351 1.579
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.026351 1.579
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.027133 1.567
R-HSA-73887 Death Receptor Signaling 0.029011 1.537
R-HSA-416482 G alpha (12/13) signalling events 0.029056 1.537
R-HSA-5602636 IKBKB deficiency causes SCID 0.039267 1.406
R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... 0.039267 1.406
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 0.052011 1.284
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 0.052011 1.284
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 0.052011 1.284
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 0.052011 1.284
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 0.052011 1.284
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 0.052011 1.284
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 0.052011 1.284
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 0.052011 1.284
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 0.052011 1.284
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 0.052011 1.284
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 0.052011 1.284
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.064588 1.190
R-HSA-9944971 Loss of Function of KMT2D in Kabuki Syndrome 0.064588 1.190
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 0.064588 1.190
R-HSA-9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 0.064588 1.190
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.076998 1.114
R-HSA-74713 IRS activation 0.089245 1.049
R-HSA-9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 0.089245 1.049
R-HSA-9645135 STAT5 Activation 0.113255 0.946
R-HSA-177539 Autointegration results in viral DNA circles 0.113255 0.946
R-HSA-9732724 IFNG signaling activates MAPKs 0.125022 0.903
R-HSA-112412 SOS-mediated signalling 0.125022 0.903
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.125022 0.903
R-HSA-8875656 MET receptor recycling 0.136635 0.864
R-HSA-9768778 Regulation of NPAS4 mRNA translation 0.136635 0.864
R-HSA-9660537 Signaling by MRAS-complex mutants 0.136635 0.864
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.136635 0.864
R-HSA-201688 WNT mediated activation of DVL 0.148093 0.829
R-HSA-9759811 Regulation of CDH11 mRNA translation by microRNAs 0.170559 0.768
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.170559 0.768
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.170559 0.768
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.170559 0.768
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.181569 0.741
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.181569 0.741
R-HSA-5339716 Signaling by GSK3beta mutants 0.181569 0.741
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 0.068845 1.162
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.192434 0.716
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.192434 0.716
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.192434 0.716
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.192434 0.716
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.192434 0.716
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.203156 0.692
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.203156 0.692
R-HSA-418885 DCC mediated attractive signaling 0.224176 0.649
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 0.224176 0.649
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.224176 0.649
R-HSA-196299 Beta-catenin phosphorylation cascade 0.224176 0.649
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.234478 0.630
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.234478 0.630
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.254675 0.594
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.063780 1.195
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.070577 1.151
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.070577 1.151
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.274342 0.562
R-HSA-9656223 Signaling by RAF1 mutants 0.139880 0.854
R-HSA-8854518 AURKA Activation by TPX2 0.077686 1.110
R-HSA-9909620 Regulation of PD-L1(CD274) translation 0.283981 0.547
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.283981 0.547
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.283981 0.547
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.283981 0.547
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.283981 0.547
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.283981 0.547
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.095421 1.020
R-HSA-9649948 Signaling downstream of RAS mutants 0.162966 0.788
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 0.302878 0.519
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.302878 0.519
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 0.302878 0.519
R-HSA-380287 Centrosome maturation 0.100768 0.997
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.312139 0.506
R-HSA-8943723 Regulation of PTEN mRNA translation 0.321278 0.493
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.141270 0.850
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.254899 0.594
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.084222 1.075
R-HSA-72163 mRNA Splicing - Major Pathway 0.317603 0.498
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.040895 1.388
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.040895 1.388
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.044771 1.349
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.040895 1.388
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.072595 1.139
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.087630 1.057
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.162966 0.788
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.162966 0.788
R-HSA-5674135 MAP2K and MAPK activation 0.139880 0.854
R-HSA-198203 PI3K/AKT activation 0.159401 0.798
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.234478 0.630
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.312139 0.506
R-HSA-6802949 Signaling by RAS mutants 0.162966 0.788
R-HSA-418886 Netrin mediated repulsion signals 0.125022 0.903
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.244644 0.611
R-HSA-74158 RNA Polymerase III Transcription 0.113270 0.946
R-HSA-162592 Integration of provirus 0.181569 0.741
R-HSA-4608870 Asymmetric localization of PCP proteins 0.034814 1.458
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.113270 0.946
R-HSA-426496 Post-transcriptional silencing by small RNAs 0.089245 1.049
R-HSA-912526 Interleukin receptor SHC signaling 0.058006 1.237
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.181569 0.741
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 0.213736 0.670
R-HSA-9664420 Killing mechanisms 0.234478 0.630
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 0.234478 0.630
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.117608 0.930
R-HSA-4086400 PCP/CE pathway 0.109007 0.963
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.068845 1.162
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO 0.148093 0.829
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.072595 1.139
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.279511 0.554
R-HSA-4791275 Signaling by WNT in cancer 0.092266 1.035
R-HSA-5603029 IkBA variant leads to EDA-ID 0.101330 0.994
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.038412 1.416
R-HSA-428543 Inactivation of CDC42 and RAC1 0.148093 0.829
R-HSA-350054 Notch-HLH transcription pathway 0.054539 1.263
R-HSA-4839744 Signaling by APC mutants 0.170559 0.768
R-HSA-4839748 Signaling by AMER1 mutants 0.181569 0.741
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.192434 0.716
R-HSA-418890 Role of second messengers in netrin-1 signaling 0.192434 0.716
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.203156 0.692
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.130862 0.883
R-HSA-113510 E2F mediated regulation of DNA replication 0.274342 0.562
R-HSA-933542 TRAF6 mediated NF-kB activation 0.330296 0.481
R-HSA-6807070 PTEN Regulation 0.059525 1.225
R-HSA-2428928 IRS-related events triggered by IGF1R 0.235242 0.628
R-HSA-9842860 Regulation of endogenous retroelements 0.066077 1.180
R-HSA-112399 IRS-mediated signalling 0.215679 0.666
R-HSA-74749 Signal attenuation 0.159401 0.798
R-HSA-9603381 Activated NTRK3 signals through PI3K 0.125022 0.903
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.054539 1.263
R-HSA-3214815 HDACs deacetylate histones 0.205955 0.686
R-HSA-74751 Insulin receptor signalling cascade 0.249980 0.602
R-HSA-5357905 Regulation of TNFR1 signaling 0.162966 0.788
R-HSA-9682385 FLT3 signaling in disease 0.113270 0.946
R-HSA-195721 Signaling by WNT 0.135774 0.867
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 0.330296 0.481
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.264574 0.577
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.130862 0.883
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.130862 0.883
R-HSA-2428924 IGF1R signaling cascade 0.249980 0.602
R-HSA-1257604 PIP3 activates AKT signaling 0.062440 1.205
R-HSA-75893 TNF signaling 0.210812 0.676
R-HSA-376172 DSCAM interactions 0.052011 1.284
R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.101330 0.994
R-HSA-175567 Integration of viral DNA into host genomic DNA 0.113255 0.946
R-HSA-164843 2-LTR circle formation 0.159401 0.798
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 0.181569 0.741
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 0.224176 0.649
R-HSA-937041 IKK complex recruitment mediated by RIP1 0.274342 0.562
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.293492 0.532
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.293492 0.532
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.293492 0.532
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.330296 0.481
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.126227 0.899
R-HSA-3858494 Beta-catenin independent WNT signaling 0.149834 0.824
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.252611 0.598
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.254899 0.594
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 0.330296 0.481
R-HSA-9842663 Signaling by LTK 0.192434 0.716
R-HSA-446353 Cell-extracellular matrix interactions 0.224176 0.649
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 0.244644 0.611
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.269667 0.569
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.284430 0.546
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.077686 1.110
R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.038412 1.416
R-HSA-9758274 Regulation of NF-kappa B signaling 0.234478 0.630
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.330296 0.481
R-HSA-9006925 Intracellular signaling by second messengers 0.114141 0.943
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.264574 0.577
R-HSA-162594 Early Phase of HIV Life Cycle 0.293492 0.532
R-HSA-1980143 Signaling by NOTCH1 0.103486 0.985
R-HSA-427652 Sodium-coupled phosphate cotransporters 0.101330 0.994
R-HSA-937039 IRAK1 recruits IKK complex 0.192434 0.716
R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.192434 0.716
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.213736 0.670
R-HSA-69202 Cyclin E associated events during G1/S transition 0.087630 1.057
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 0.302878 0.519
R-HSA-429947 Deadenylation of mRNA 0.330296 0.481
R-HSA-68877 Mitotic Prometaphase 0.314607 0.502
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.249980 0.602
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.068845 1.162
R-HSA-9659379 Sensory processing of sound 0.323605 0.490
R-HSA-430116 GP1b-IX-V activation signalling 0.148093 0.829
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.158294 0.801
R-HSA-9031628 NGF-stimulated transcription 0.039910 1.399
R-HSA-8854214 TBC/RABGAPs 0.031617 1.500
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.104725 0.980
R-HSA-73864 RNA Polymerase I Transcription 0.109007 0.963
R-HSA-2559585 Oncogene Induced Senescence 0.108975 0.963
R-HSA-388841 Regulation of T cell activation by CD28 family 0.309359 0.510
R-HSA-8853659 RET signaling 0.113270 0.946
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 0.101330 0.994
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.170559 0.768
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.213736 0.670
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.224176 0.649
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.293492 0.532
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.302878 0.519
R-HSA-74160 Gene expression (Transcription) 0.036161 1.442
R-HSA-9768759 Regulation of NPAS4 gene expression 0.254675 0.594
R-HSA-9843745 Adipogenesis 0.135360 0.869
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.101330 0.994
R-HSA-390696 Adrenoceptors 0.136635 0.864
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 0.044610 1.351
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.213736 0.670
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.234478 0.630
R-HSA-9909505 Modulation of host responses by IFN-stimulated genes 0.254675 0.594
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.264574 0.577
R-HSA-844456 The NLRP3 inflammasome 0.274342 0.562
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.144439 0.840
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.092793 1.032
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.106232 0.974
R-HSA-109704 PI3K Cascade 0.181887 0.740
R-HSA-5617833 Cilium Assembly 0.305635 0.515
R-HSA-1640170 Cell Cycle 0.179114 0.747
R-HSA-69278 Cell Cycle, Mitotic 0.260755 0.584
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.092793 1.032
R-HSA-5689880 Ub-specific processing proteases 0.255509 0.593
R-HSA-73857 RNA Polymerase II Transcription 0.050911 1.293
R-HSA-212436 Generic Transcription Pathway 0.047286 1.325
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.158294 0.801
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.159401 0.798
R-HSA-525793 Myogenesis 0.068845 1.162
R-HSA-392517 Rap1 signalling 0.274342 0.562
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.302878 0.519
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.312139 0.506
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.087630 1.057
R-HSA-69206 G1/S Transition 0.287821 0.541
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.203156 0.692
R-HSA-9006931 Signaling by Nuclear Receptors 0.143017 0.845
R-HSA-8939211 ESR-mediated signaling 0.131823 0.880
R-HSA-8983432 Interleukin-15 signaling 0.192434 0.716
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.126048 0.899
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.192434 0.716
R-HSA-2586552 Signaling by Leptin 0.159401 0.798
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.144439 0.840
R-HSA-9034015 Signaling by NTRK3 (TRKC) 0.302878 0.519
R-HSA-451927 Interleukin-2 family signaling 0.130862 0.883
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.136635 0.864
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.148093 0.829
R-HSA-391160 Signal regulatory protein family interactions 0.213736 0.670
R-HSA-210991 Basigin interactions 0.293492 0.532
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.308961 0.510
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.259071 0.587
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.274342 0.562
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.095778 1.019
R-HSA-1500931 Cell-Cell communication 0.293765 0.532
R-HSA-9007101 Rab regulation of trafficking 0.255503 0.593
R-HSA-166520 Signaling by NTRKs 0.183066 0.737
R-HSA-9671555 Signaling by PDGFR in disease 0.302878 0.519
R-HSA-194138 Signaling by VEGF 0.119250 0.924
R-HSA-2243919 Crosslinking of collagen fibrils 0.274342 0.562
R-HSA-1538133 G0 and Early G1 0.092266 1.035
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.096368 1.016
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.312139 0.506
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.144031 0.842
R-HSA-6804757 Regulation of TP53 Degradation 0.113270 0.946
R-HSA-3000170 Syndecan interactions 0.321278 0.493
R-HSA-9855142 Cellular responses to mechanical stimuli 0.237780 0.624
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.126406 0.898
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.177125 0.752
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.321278 0.493
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.240150 0.620
R-HSA-75153 Apoptotic execution phase 0.036472 1.438
R-HSA-9833482 PKR-mediated signaling 0.328469 0.484
R-HSA-109581 Apoptosis 0.095150 1.022
R-HSA-9682706 Replication of the SARS-CoV-1 genome 0.203156 0.692
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.230340 0.638
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.230340 0.638
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.230340 0.638
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.230340 0.638
R-HSA-9694686 Replication of the SARS-CoV-2 genome 0.254675 0.594
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.330296 0.481
R-HSA-8863678 Neurodegenerative Diseases 0.330296 0.481
R-HSA-9679514 SARS-CoV-1 Genome Replication and Transcription 0.213736 0.670
R-HSA-5357801 Programmed Cell Death 0.184240 0.735
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription 0.274342 0.562
R-HSA-982772 Growth hormone receptor signaling 0.321278 0.493
R-HSA-2028269 Signaling by Hippo 0.254675 0.594
R-HSA-5633007 Regulation of TP53 Activity 0.215671 0.666
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.230340 0.638
R-HSA-193704 p75 NTR receptor-mediated signalling 0.061133 1.214
R-HSA-389948 Co-inhibition by PD-1 0.335624 0.474
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.339195 0.470
R-HSA-9839394 TGFBR3 expression 0.339195 0.470
R-HSA-9620244 Long-term potentiation 0.339195 0.470
R-HSA-420029 Tight junction interactions 0.339195 0.470
R-HSA-9932444 ATP-dependent chromatin remodelers 0.339195 0.470
R-HSA-9932451 SWI/SNF chromatin remodelers 0.339195 0.470
R-HSA-3214842 HDMs demethylate histones 0.339195 0.470
R-HSA-1266695 Interleukin-7 signaling 0.339195 0.470
R-HSA-9707564 Cytoprotection by HMOX1 0.343003 0.465
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.347976 0.458
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.347976 0.458
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.347976 0.458
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.347976 0.458
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.347976 0.458
R-HSA-9664417 Leishmania phagocytosis 0.349466 0.457
R-HSA-9664407 Parasite infection 0.349466 0.457
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.349466 0.457
R-HSA-72172 mRNA Splicing 0.350677 0.455
R-HSA-6802957 Oncogenic MAPK signaling 0.352638 0.453
R-HSA-1500620 Meiosis 0.352638 0.453
R-HSA-6794362 Protein-protein interactions at synapses 0.352638 0.453
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.353089 0.452
R-HSA-76002 Platelet activation, signaling and aggregation 0.356443 0.448
R-HSA-73863 RNA Polymerase I Transcription Termination 0.356642 0.448
R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.356642 0.448
R-HSA-264876 Insulin processing 0.356642 0.448
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.356642 0.448
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.362223 0.441
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.365192 0.437
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.365192 0.437
R-HSA-622312 Inflammasomes 0.365192 0.437
R-HSA-73614 Pyrimidine salvage 0.365192 0.437
R-HSA-446728 Cell junction organization 0.366969 0.435
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.373629 0.428
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.373629 0.428
R-HSA-5656169 Termination of translesion DNA synthesis 0.373629 0.428
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.373629 0.428
R-HSA-9674555 Signaling by CSF3 (G-CSF) 0.373629 0.428
R-HSA-180024 DARPP-32 events 0.373629 0.428
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.374770 0.426
R-HSA-9824443 Parasitic Infection Pathways 0.374868 0.426
R-HSA-9658195 Leishmania infection 0.374868 0.426
R-HSA-112310 Neurotransmitter release cycle 0.381231 0.419
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.381955 0.418
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.381955 0.418
R-HSA-8863795 Downregulation of ERBB2 signaling 0.381955 0.418
R-HSA-69242 S Phase 0.381968 0.418
R-HSA-9856651 MITF-M-dependent gene expression 0.389148 0.410
R-HSA-9679191 Potential therapeutics for SARS 0.389148 0.410
R-HSA-162588 Budding and maturation of HIV virion 0.390170 0.409
R-HSA-5694530 Cargo concentration in the ER 0.390170 0.409
R-HSA-186763 Downstream signal transduction 0.390170 0.409
R-HSA-74752 Signaling by Insulin receptor 0.395330 0.403
R-HSA-9675126 Diseases of mitotic cell cycle 0.398277 0.400
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.398277 0.400
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.404647 0.393
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.406277 0.391
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 0.406277 0.391
R-HSA-1839124 FGFR1 mutant receptor activation 0.406277 0.391
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.406277 0.391
R-HSA-354192 Integrin signaling 0.406277 0.391
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.406277 0.391
R-HSA-176187 Activation of ATR in response to replication stress 0.406277 0.391
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.406277 0.391
R-HSA-390522 Striated Muscle Contraction 0.414170 0.383
R-HSA-5693537 Resolution of D-Loop Structures 0.414170 0.383
R-HSA-5223345 Miscellaneous transport and binding events 0.414170 0.383
R-HSA-114508 Effects of PIP2 hydrolysis 0.414170 0.383
R-HSA-9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membra... 0.414170 0.383
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.418494 0.378
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.421960 0.375
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.421960 0.375
R-HSA-5673000 RAF activation 0.421960 0.375
R-HSA-168638 NOD1/2 Signaling Pathway 0.421960 0.375
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.423074 0.374
R-HSA-9006936 Signaling by TGFB family members 0.424707 0.372
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.429646 0.367
R-HSA-381042 PERK regulates gene expression 0.429646 0.367
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.429646 0.367
R-HSA-163560 Triglyceride catabolism 0.437230 0.359
R-HSA-8941326 RUNX2 regulates bone development 0.437230 0.359
R-HSA-69205 G1/S-Specific Transcription 0.437230 0.359
R-HSA-9020702 Interleukin-1 signaling 0.441204 0.355
R-HSA-4641257 Degradation of AXIN 0.444714 0.352
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.444714 0.352
R-HSA-4641258 Degradation of DVL 0.444714 0.352
R-HSA-419037 NCAM1 interactions 0.444714 0.352
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.444714 0.352
R-HSA-5689896 Ovarian tumor domain proteases 0.444714 0.352
R-HSA-68886 M Phase 0.451357 0.345
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.452099 0.345
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.452099 0.345
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.454596 0.342
R-HSA-9860931 Response of endothelial cells to shear stress 0.454596 0.342
R-HSA-157118 Signaling by NOTCH 0.458014 0.339
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.459386 0.338
R-HSA-201556 Signaling by ALK 0.459386 0.338
R-HSA-8953750 Transcriptional Regulation by E2F6 0.459386 0.338
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.466577 0.331
R-HSA-5260271 Diseases of Immune System 0.466577 0.331
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.466577 0.331
R-HSA-202433 Generation of second messenger molecules 0.466577 0.331
R-HSA-3700989 Transcriptional Regulation by TP53 0.472898 0.325
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.473224 0.325
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.473224 0.325
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.473672 0.325
R-HSA-9607240 FLT3 Signaling 0.473672 0.325
R-HSA-8853884 Transcriptional Regulation by VENTX 0.473672 0.325
R-HSA-9821002 Chromatin modifications during the maternal to zygotic transition (MZT) 0.473672 0.325
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.473672 0.325
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.473672 0.325
R-HSA-1852241 Organelle biogenesis and maintenance 0.476469 0.322
R-HSA-2672351 Stimuli-sensing channels 0.476502 0.322
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.476621 0.322
R-HSA-5675221 Negative regulation of MAPK pathway 0.480674 0.318
R-HSA-5655302 Signaling by FGFR1 in disease 0.480674 0.318
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 0.480674 0.318
R-HSA-202403 TCR signaling 0.485114 0.314
R-HSA-421270 Cell-cell junction organization 0.489771 0.310
R-HSA-8953897 Cellular responses to stimuli 0.492038 0.308
R-HSA-1433557 Signaling by SCF-KIT 0.494400 0.306
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.494400 0.306
R-HSA-73621 Pyrimidine catabolism 0.494400 0.306
R-HSA-373752 Netrin-1 signaling 0.501127 0.300
R-HSA-69236 G1 Phase 0.501127 0.300
R-HSA-69231 Cyclin D associated events in G1 0.501127 0.300
R-HSA-375280 Amine ligand-binding receptors 0.501127 0.300
R-HSA-5683826 Surfactant metabolism 0.501127 0.300
R-HSA-5688426 Deubiquitination 0.501133 0.300
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.502074 0.299
R-HSA-201681 TCF dependent signaling in response to WNT 0.506722 0.295
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.507765 0.294
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.507765 0.294
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.510419 0.292
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.514315 0.289
R-HSA-9675135 Diseases of DNA repair 0.514315 0.289
R-HSA-2299718 Condensation of Prophase Chromosomes 0.514315 0.289
R-HSA-9839373 Signaling by TGFBR3 0.514315 0.289
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.514315 0.289
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.514315 0.289
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.520778 0.283
R-HSA-5693538 Homology Directed Repair 0.526833 0.278
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.527156 0.278
R-HSA-389356 Co-stimulation by CD28 0.527156 0.278
R-HSA-73893 DNA Damage Bypass 0.533449 0.273
R-HSA-68875 Mitotic Prophase 0.534900 0.272
R-HSA-5683057 MAPK family signaling cascades 0.543649 0.265
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.545787 0.263
R-HSA-912446 Meiotic recombination 0.545787 0.263
R-HSA-1169091 Activation of NF-kappaB in B cells 0.545787 0.263
R-HSA-9864848 Complex IV assembly 0.545787 0.263
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.546824 0.262
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.546824 0.262
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.548566 0.261
R-HSA-6794361 Neurexins and neuroligins 0.551833 0.258
R-HSA-9634815 Transcriptional Regulation by NPAS4 0.551833 0.258
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.557799 0.254
R-HSA-1221632 Meiotic synapsis 0.557799 0.254
R-HSA-445355 Smooth Muscle Contraction 0.557799 0.254
R-HSA-72649 Translation initiation complex formation 0.563686 0.249
R-HSA-69481 G2/M Checkpoints 0.566220 0.247
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.566809 0.247
R-HSA-418597 G alpha (z) signalling events 0.569495 0.245
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.574684 0.241
R-HSA-72702 Ribosomal scanning and start codon recognition 0.575228 0.240
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.575228 0.240
R-HSA-5578775 Ion homeostasis 0.575228 0.240
R-HSA-177929 Signaling by EGFR 0.575228 0.240
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.575228 0.240
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.577570 0.238
R-HSA-2980766 Nuclear Envelope Breakdown 0.580884 0.236
R-HSA-1483166 Synthesis of PA 0.580884 0.236
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.580884 0.236
R-HSA-1474165 Reproduction 0.581304 0.236
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.586465 0.232
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.586465 0.232
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.586465 0.232
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.586465 0.232
R-HSA-9909396 Circadian clock 0.588701 0.230
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.591972 0.228
R-HSA-8979227 Triglyceride metabolism 0.591972 0.228
R-HSA-429914 Deadenylation-dependent mRNA decay 0.591972 0.228
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.591972 0.228
R-HSA-352230 Amino acid transport across the plasma membrane 0.591972 0.228
R-HSA-5673001 RAF/MAP kinase cascade 0.592744 0.227
R-HSA-977443 GABA receptor activation 0.597406 0.224
R-HSA-1227986 Signaling by ERBB2 0.597406 0.224
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.597406 0.224
R-HSA-450294 MAP kinase activation 0.602769 0.220
R-HSA-8956321 Nucleotide salvage 0.602769 0.220
R-HSA-1442490 Collagen degradation 0.602769 0.220
R-HSA-9730414 MITF-M-regulated melanocyte development 0.602940 0.220
R-HSA-375165 NCAM signaling for neurite out-growth 0.608060 0.216
R-HSA-9707616 Heme signaling 0.608060 0.216
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.608060 0.216
R-HSA-186797 Signaling by PDGF 0.608060 0.216
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.608060 0.216
R-HSA-5684996 MAPK1/MAPK3 signaling 0.610348 0.214
R-HSA-69615 G1/S DNA Damage Checkpoints 0.613281 0.212
R-HSA-8848021 Signaling by PTK6 0.613281 0.212
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.613281 0.212
R-HSA-418990 Adherens junctions interactions 0.617262 0.210
R-HSA-1234174 Cellular response to hypoxia 0.623516 0.205
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.628574 0.202
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.633481 0.198
R-HSA-5693606 DNA Double Strand Break Response 0.633481 0.198
R-HSA-9958863 SLC-mediated transport of amino acids 0.633481 0.198
R-HSA-8856828 Clathrin-mediated endocytosis 0.634421 0.198
R-HSA-2262752 Cellular responses to stress 0.635153 0.197
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.638365 0.195
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.647939 0.188
R-HSA-448424 Interleukin-17 signaling 0.647939 0.188
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.647939 0.188
R-HSA-3000178 ECM proteoglycans 0.652631 0.185
R-HSA-453276 Regulation of mitotic cell cycle 0.652631 0.185
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.652631 0.185
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.657261 0.182
R-HSA-4086398 Ca2+ pathway 0.661829 0.179
R-HSA-446652 Interleukin-1 family signaling 0.663694 0.178
R-HSA-69473 G2/M DNA damage checkpoint 0.666337 0.176
R-HSA-1226099 Signaling by FGFR in disease 0.666337 0.176
R-HSA-5693532 DNA Double-Strand Break Repair 0.666828 0.176
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.669938 0.174
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.670785 0.173
R-HSA-1280218 Adaptive Immune System 0.672673 0.172
R-HSA-112315 Transmission across Chemical Synapses 0.673746 0.172
R-HSA-9610379 HCMV Late Events 0.679129 0.168
R-HSA-162587 HIV Life Cycle 0.679129 0.168
R-HSA-216083 Integrin cell surface interactions 0.683778 0.165
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.692155 0.160
R-HSA-6806834 Signaling by MET 0.692155 0.160
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.692155 0.160
R-HSA-5693607 Processing of DNA double-strand break ends 0.696260 0.157
R-HSA-977225 Amyloid fiber formation 0.696260 0.157
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.696260 0.157
R-HSA-9609646 HCMV Infection 0.700519 0.155
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.708252 0.150
R-HSA-5687128 MAPK6/MAPK4 signaling 0.712144 0.147
R-HSA-1266738 Developmental Biology 0.712316 0.147
R-HSA-5621481 C-type lectin receptors (CLRs) 0.721999 0.141
R-HSA-438064 Post NMDA receptor activation events 0.723511 0.141
R-HSA-9645723 Diseases of programmed cell death 0.727200 0.138
R-HSA-1236974 ER-Phagosome pathway 0.730840 0.136
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.732587 0.135
R-HSA-202424 Downstream TCR signaling 0.734432 0.134
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.737976 0.132
R-HSA-109582 Hemostasis 0.751558 0.124
R-HSA-1474290 Collagen formation 0.751687 0.124
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.755002 0.122
R-HSA-72689 Formation of a pool of free 40S subunits 0.758272 0.120
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.761499 0.118
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.761499 0.118
R-HSA-983712 Ion channel transport 0.766991 0.115
R-HSA-8957275 Post-translational protein phosphorylation 0.767826 0.115
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.767826 0.115
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.767826 0.115
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.767826 0.115
R-HSA-422356 Regulation of insulin secretion 0.767826 0.115
R-HSA-3214847 HATs acetylate histones 0.770926 0.113
R-HSA-9614085 FOXO-mediated transcription 0.770926 0.113
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.779981 0.108
R-HSA-1483255 PI Metabolism 0.779981 0.108
R-HSA-9609690 HCMV Early Events 0.782711 0.106
R-HSA-112316 Neuronal System 0.783845 0.106
R-HSA-111885 Opioid Signalling 0.785820 0.105
R-HSA-9833110 RSV-host interactions 0.788681 0.103
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.791504 0.102
R-HSA-1643685 Disease 0.792840 0.101
R-HSA-211000 Gene Silencing by RNA 0.797038 0.099
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.797497 0.098
R-HSA-376176 Signaling by ROBO receptors 0.797497 0.098
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.799749 0.097
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.799749 0.097
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.799749 0.097
R-HSA-1236975 Antigen processing-Cross presentation 0.799749 0.097
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.802425 0.096
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.805065 0.094
R-HSA-166166 MyD88-independent TLR4 cascade 0.805065 0.094
R-HSA-6803157 Antimicrobial peptides 0.807670 0.093
R-HSA-1483249 Inositol phosphate metabolism 0.810241 0.091
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.812777 0.090
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.812777 0.090
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.817080 0.088
R-HSA-397014 Muscle contraction 0.817080 0.088
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 0.817749 0.087
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.820185 0.086
R-HSA-72737 Cap-dependent Translation Initiation 0.824961 0.084
R-HSA-72613 Eukaryotic Translation Initiation 0.824961 0.084
R-HSA-1592230 Mitochondrial biogenesis 0.827301 0.082
R-HSA-2980736 Peptide hormone metabolism 0.827301 0.082
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.831889 0.080
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.831889 0.080
R-HSA-8878166 Transcriptional regulation by RUNX2 0.831889 0.080
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.838544 0.076
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.838544 0.076
R-HSA-6809371 Formation of the cornified envelope 0.842834 0.074
R-HSA-162909 Host Interactions of HIV factors 0.842834 0.074
R-HSA-162906 HIV Infection 0.843296 0.074
R-HSA-1474244 Extracellular matrix organization 0.849311 0.071
R-HSA-114608 Platelet degranulation 0.851077 0.070
R-HSA-8956319 Nucleotide catabolism 0.855036 0.068
R-HSA-202733 Cell surface interactions at the vascular wall 0.858837 0.066
R-HSA-5576891 Cardiac conduction 0.860779 0.065
R-HSA-1474228 Degradation of the extracellular matrix 0.862642 0.064
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.864481 0.063
R-HSA-163685 Integration of energy metabolism 0.871593 0.060
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.873313 0.059
R-HSA-422475 Axon guidance 0.876518 0.057
R-HSA-381119 Unfolded Protein Response (UPR) 0.876683 0.057
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.883158 0.054
R-HSA-162599 Late Phase of HIV Life Cycle 0.883158 0.054
R-HSA-73894 DNA Repair 0.884347 0.053
R-HSA-199991 Membrane Trafficking 0.885295 0.053
R-HSA-9679506 SARS-CoV Infections 0.885659 0.053
R-HSA-2871837 FCERI mediated NF-kB activation 0.886267 0.052
R-HSA-69620 Cell Cycle Checkpoints 0.886997 0.052
R-HSA-199977 ER to Golgi Anterograde Transport 0.890778 0.050
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.892241 0.050
R-HSA-9758941 Gastrulation 0.893685 0.049
R-HSA-9711123 Cellular response to chemical stress 0.898500 0.046
R-HSA-9824446 Viral Infection Pathways 0.905006 0.043
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.905845 0.043
R-HSA-877300 Interferon gamma signaling 0.907107 0.042
R-HSA-9675108 Nervous system development 0.907510 0.042
R-HSA-913531 Interferon Signaling 0.907672 0.042
R-HSA-388396 GPCR downstream signalling 0.909701 0.041
R-HSA-418555 G alpha (s) signalling events 0.922065 0.035
R-HSA-1483257 Phospholipid metabolism 0.924352 0.034
R-HSA-9678108 SARS-CoV-1 Infection 0.926166 0.033
R-HSA-611105 Respiratory electron transport 0.929099 0.032
R-HSA-449147 Signaling by Interleukins 0.934843 0.029
R-HSA-168898 Toll-like Receptor Cascades 0.940529 0.027
R-HSA-428157 Sphingolipid metabolism 0.948056 0.023
R-HSA-948021 Transport to the Golgi and subsequent modification 0.948755 0.023
R-HSA-1483206 Glycerophospholipid biosynthesis 0.949444 0.023
R-HSA-372790 Signaling by GPCR 0.951157 0.022
R-HSA-6805567 Keratinization 0.952109 0.021
R-HSA-168249 Innate Immune System 0.952866 0.021
R-HSA-5663205 Infectious disease 0.954146 0.020
R-HSA-68882 Mitotic Anaphase 0.958176 0.019
R-HSA-9694516 SARS-CoV-2 Infection 0.958633 0.018
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.958739 0.018
R-HSA-8951664 Neddylation 0.960916 0.017
R-HSA-9705683 SARS-CoV-2-host interactions 0.964455 0.016
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.964933 0.016
R-HSA-5653656 Vesicle-mediated transport 0.967332 0.014
R-HSA-15869 Metabolism of nucleotides 0.968110 0.014
R-HSA-8953854 Metabolism of RNA 0.974027 0.011
R-HSA-425407 SLC-mediated transmembrane transport 0.976438 0.010
R-HSA-416476 G alpha (q) signalling events 0.978196 0.010
R-HSA-418594 G alpha (i) signalling events 0.979027 0.009
R-HSA-168256 Immune System 0.986320 0.006
R-HSA-6798695 Neutrophil degranulation 0.988363 0.005
R-HSA-1280215 Cytokine Signaling in Immune system 0.992010 0.003
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.992363 0.003
R-HSA-597592 Post-translational protein modification 0.995752 0.002
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.996352 0.002
R-HSA-446203 Asparagine N-linked glycosylation 0.997515 0.001
R-HSA-382551 Transport of small molecules 0.997722 0.001
R-HSA-72766 Translation 0.997743 0.001
R-HSA-500792 GPCR ligand binding 0.999752 0.000
R-HSA-392499 Metabolism of proteins 0.999777 0.000
R-HSA-556833 Metabolism of lipids 0.999999 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 -0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.880 0.403 1 0.846
COTCOT 0.875 0.278 2 0.896
PIM3PIM3 0.869 0.297 -3 0.877
RSK2RSK2 0.869 0.313 -3 0.834
NDR2NDR2 0.866 0.244 -3 0.884
CLK2CLK2 0.865 0.401 -3 0.811
SRPK1SRPK1 0.864 0.275 -3 0.811
P90RSKP90RSK 0.861 0.267 -3 0.837
HIPK4HIPK4 0.861 0.291 1 0.833
SKMLCKSKMLCK 0.858 0.301 -2 0.883
PIM1PIM1 0.858 0.277 -3 0.825
PRKD1PRKD1 0.857 0.230 -3 0.874
RSK4RSK4 0.857 0.308 -3 0.824
MTORMTOR 0.856 0.128 1 0.783
MOSMOS 0.855 0.154 1 0.823
CDC7CDC7 0.855 0.082 1 0.798
CDKL1CDKL1 0.855 0.222 -3 0.841
RSK3RSK3 0.855 0.236 -3 0.825
PRKD2PRKD2 0.855 0.227 -3 0.835
DYRK2DYRK2 0.854 0.298 1 0.792
NDR1NDR1 0.854 0.189 -3 0.868
NLKNLK 0.853 0.203 1 0.866
CDKL5CDKL5 0.853 0.216 -3 0.840
MAPKAPK2MAPKAPK2 0.852 0.211 -3 0.797
AURCAURC 0.852 0.250 -2 0.712
SRPK2SRPK2 0.852 0.235 -3 0.744
CAMK1BCAMK1B 0.852 0.172 -3 0.867
GRK1GRK1 0.852 0.190 -2 0.810
CLK4CLK4 0.851 0.300 -3 0.811
ICKICK 0.851 0.263 -3 0.873
PKACBPKACB 0.851 0.278 -2 0.721
ERK5ERK5 0.850 0.166 1 0.840
PRPKPRPK 0.850 -0.016 -1 0.843
CAMK2DCAMK2D 0.849 0.169 -3 0.856
P70S6KBP70S6KB 0.849 0.210 -3 0.832
IKKBIKKB 0.848 -0.015 -2 0.739
CAMK2ACAMK2A 0.848 0.227 2 0.855
HIPK2HIPK2 0.848 0.301 1 0.722
ATRATR 0.848 0.096 1 0.825
PKACGPKACG 0.848 0.198 -2 0.777
CAMLCKCAMLCK 0.848 0.212 -2 0.873
CAMK2BCAMK2B 0.848 0.205 2 0.841
CLK1CLK1 0.847 0.287 -3 0.797
PRKXPRKX 0.847 0.280 -3 0.758
DSTYKDSTYK 0.847 0.025 2 0.922
MSK1MSK1 0.846 0.252 -3 0.797
LATS2LATS2 0.846 0.122 -5 0.730
KISKIS 0.846 0.168 1 0.774
RAF1RAF1 0.846 -0.008 1 0.799
CAMK2GCAMK2G 0.846 0.024 2 0.850
MAPKAPK3MAPKAPK3 0.846 0.157 -3 0.826
DYRK4DYRK4 0.846 0.302 1 0.731
PKN3PKN3 0.845 0.107 -3 0.857
DAPK2DAPK2 0.845 0.214 -3 0.875
SRPK3SRPK3 0.844 0.194 -3 0.775
HIPK1HIPK1 0.844 0.306 1 0.804
MST4MST4 0.844 0.110 2 0.870
MSK2MSK2 0.844 0.188 -3 0.794
WNK1WNK1 0.844 0.098 -2 0.880
GCN2GCN2 0.843 -0.111 2 0.810
PKCDPKCD 0.843 0.172 2 0.802
JNK2JNK2 0.843 0.262 1 0.722
NUAK2NUAK2 0.842 0.113 -3 0.869
PAK1PAK1 0.842 0.180 -2 0.823
PDHK4PDHK4 0.842 -0.167 1 0.818
PKN2PKN2 0.842 0.120 -3 0.847
NIKNIK 0.841 0.119 -3 0.869
LATS1LATS1 0.841 0.236 -3 0.902
CDK18CDK18 0.841 0.243 1 0.715
NEK6NEK6 0.841 0.030 -2 0.848
TBK1TBK1 0.841 -0.083 1 0.698
BMPR2BMPR2 0.841 -0.089 -2 0.877
TGFBR2TGFBR2 0.840 0.047 -2 0.818
CDK7CDK7 0.840 0.192 1 0.765
CDK8CDK8 0.840 0.164 1 0.757
IKKEIKKE 0.839 -0.079 1 0.694
ULK2ULK2 0.838 -0.110 2 0.780
CDK19CDK19 0.838 0.178 1 0.728
MARK4MARK4 0.838 0.046 4 0.741
MNK2MNK2 0.838 0.174 -2 0.820
RIPK3RIPK3 0.838 -0.006 3 0.751
GRK5GRK5 0.838 -0.046 -3 0.790
AKT2AKT2 0.838 0.231 -3 0.756
JNK3JNK3 0.837 0.226 1 0.743
CDK1CDK1 0.837 0.202 1 0.741
IKKAIKKA 0.837 0.020 -2 0.728
FAM20CFAM20C 0.837 0.119 2 0.682
BMPR1BBMPR1B 0.836 0.178 1 0.780
GRK6GRK6 0.836 0.045 1 0.803
GRK7GRK7 0.836 0.166 1 0.750
PKCAPKCA 0.836 0.171 2 0.747
PIM2PIM2 0.836 0.235 -3 0.798
TGFBR1TGFBR1 0.836 0.161 -2 0.824
AURBAURB 0.836 0.188 -2 0.711
AMPKA1AMPKA1 0.836 0.084 -3 0.872
PAK3PAK3 0.836 0.127 -2 0.816
PKG2PKG2 0.835 0.194 -2 0.717
PAK6PAK6 0.835 0.185 -2 0.756
MNK1MNK1 0.835 0.172 -2 0.828
PKCBPKCB 0.834 0.136 2 0.756
DYRK3DYRK3 0.834 0.285 1 0.802
CDK5CDK5 0.834 0.205 1 0.782
NEK7NEK7 0.834 -0.099 -3 0.820
SGK3SGK3 0.834 0.215 -3 0.809
PKCGPKCG 0.834 0.131 2 0.763
PDHK1PDHK1 0.834 -0.201 1 0.800
CDK13CDK13 0.834 0.166 1 0.742
HUNKHUNK 0.834 -0.062 2 0.828
ATMATM 0.833 0.049 1 0.766
CHAK2CHAK2 0.833 -0.020 -1 0.797
MYLK4MYLK4 0.833 0.174 -2 0.806
PRKD3PRKD3 0.833 0.144 -3 0.800
MAKMAK 0.833 0.348 -2 0.766
DNAPKDNAPK 0.833 0.142 1 0.712
P38AP38A 0.833 0.206 1 0.790
AMPKA2AMPKA2 0.832 0.103 -3 0.857
DYRK1ADYRK1A 0.832 0.235 1 0.798
P38BP38B 0.832 0.218 1 0.736
MASTLMASTL 0.832 -0.096 -2 0.815
DYRK1BDYRK1B 0.832 0.248 1 0.754
ALK4ALK4 0.832 0.106 -2 0.853
BCKDKBCKDK 0.832 -0.108 -1 0.791
PKACAPKACA 0.832 0.226 -2 0.673
MLK1MLK1 0.831 -0.097 2 0.830
AURAAURA 0.831 0.164 -2 0.689
GSK3AGSK3A 0.831 0.227 4 0.570
P38GP38G 0.830 0.205 1 0.666
HIPK3HIPK3 0.830 0.239 1 0.788
CDK12CDK12 0.829 0.178 1 0.719
NIM1NIM1 0.829 0.043 3 0.772
CDK17CDK17 0.829 0.199 1 0.670
CDK14CDK14 0.829 0.234 1 0.754
TSSK1TSSK1 0.829 0.076 -3 0.895
CDK10CDK10 0.829 0.245 1 0.742
CDK3CDK3 0.829 0.196 1 0.688
MLK2MLK2 0.829 -0.011 2 0.828
NEK9NEK9 0.828 -0.086 2 0.837
TSSK2TSSK2 0.828 0.033 -5 0.824
GRK4GRK4 0.827 -0.088 -2 0.822
DLKDLK 0.827 -0.078 1 0.796
CAMK4CAMK4 0.827 0.026 -3 0.835
ERK1ERK1 0.827 0.182 1 0.727
MLK3MLK3 0.827 0.012 2 0.768
RIPK1RIPK1 0.827 -0.076 1 0.773
QSKQSK 0.827 0.076 4 0.708
CDK9CDK9 0.827 0.151 1 0.747
PAK2PAK2 0.826 0.095 -2 0.811
PKRPKR 0.826 0.061 1 0.803
PLK1PLK1 0.825 -0.007 -2 0.799
ULK1ULK1 0.825 -0.180 -3 0.772
PASKPASK 0.825 0.215 -3 0.888
PKCZPKCZ 0.825 0.071 2 0.786
DCAMKL1DCAMKL1 0.824 0.152 -3 0.836
ANKRD3ANKRD3 0.824 -0.104 1 0.816
ALK2ALK2 0.824 0.093 -2 0.831
GSK3BGSK3B 0.824 0.163 4 0.562
MELKMELK 0.824 0.056 -3 0.842
PKCHPKCH 0.824 0.077 2 0.734
AKT1AKT1 0.823 0.207 -3 0.775
WNK3WNK3 0.823 -0.212 1 0.770
BRSK1BRSK1 0.823 0.046 -3 0.832
DRAK1DRAK1 0.822 0.080 1 0.755
SIKSIK 0.822 0.071 -3 0.799
CDK16CDK16 0.822 0.208 1 0.685
PHKG1PHKG1 0.822 0.021 -3 0.853
VRK2VRK2 0.821 -0.012 1 0.845
SMG1SMG1 0.821 0.006 1 0.784
ACVR2BACVR2B 0.821 0.057 -2 0.810
TTBK2TTBK2 0.821 -0.151 2 0.717
IRE1IRE1 0.820 -0.076 1 0.759
CHK1CHK1 0.820 0.056 -3 0.856
ACVR2AACVR2A 0.820 0.042 -2 0.799
QIKQIK 0.820 -0.022 -3 0.843
MARK3MARK3 0.820 0.032 4 0.659
NEK2NEK2 0.819 -0.035 2 0.812
YSK4YSK4 0.819 -0.073 1 0.738
MPSK1MPSK1 0.819 0.216 1 0.789
MOKMOK 0.819 0.293 1 0.814
PRP4PRP4 0.819 0.116 -3 0.748
CAMK1GCAMK1G 0.819 0.085 -3 0.802
TLK2TLK2 0.819 -0.005 1 0.769
P70S6KP70S6K 0.819 0.146 -3 0.760
SGK1SGK1 0.818 0.234 -3 0.690
MEK1MEK1 0.818 -0.109 2 0.855
P38DP38D 0.818 0.194 1 0.679
PLK3PLK3 0.818 -0.044 2 0.805
SMMLCKSMMLCK 0.818 0.144 -3 0.840
NUAK1NUAK1 0.818 0.008 -3 0.831
ERK2ERK2 0.818 0.127 1 0.759
AKT3AKT3 0.817 0.226 -3 0.711
MAPKAPK5MAPKAPK5 0.817 0.009 -3 0.766
CDK2CDK2 0.817 0.068 1 0.801
JNK1JNK1 0.816 0.185 1 0.710
MST3MST3 0.816 0.092 2 0.859
DAPK3DAPK3 0.816 0.205 -3 0.840
MLK4MLK4 0.816 -0.069 2 0.737
BRSK2BRSK2 0.816 -0.025 -3 0.837
PAK4PAK4 0.816 0.155 -2 0.710
BMPR1ABMPR1A 0.814 0.099 1 0.747
PAK5PAK5 0.814 0.132 -2 0.706
GRK2GRK2 0.814 -0.019 -2 0.710
IRE2IRE2 0.813 -0.073 2 0.729
MARK2MARK2 0.813 -0.019 4 0.624
CAMK1DCAMK1D 0.813 0.137 -3 0.748
PKCTPKCT 0.812 0.084 2 0.739
BRAFBRAF 0.812 -0.038 -4 0.823
DCAMKL2DCAMKL2 0.812 0.057 -3 0.848
DAPK1DAPK1 0.812 0.197 -3 0.821
PKCEPKCE 0.811 0.135 2 0.744
TAO3TAO3 0.811 0.040 1 0.767
NEK5NEK5 0.810 -0.002 1 0.793
WNK4WNK4 0.810 -0.029 -2 0.876
PERKPERK 0.809 -0.093 -2 0.839
MARK1MARK1 0.809 -0.027 4 0.676
ROCK2ROCK2 0.809 0.229 -3 0.828
PLK4PLK4 0.809 -0.071 2 0.625
CHAK1CHAK1 0.808 -0.166 2 0.771
MRCKBMRCKB 0.808 0.196 -3 0.783
GAKGAK 0.808 0.130 1 0.846
MEK5MEK5 0.808 -0.163 2 0.830
MEKK1MEKK1 0.808 -0.112 1 0.773
SBKSBK 0.807 0.189 -3 0.659
PKCIPKCI 0.807 0.064 2 0.753
MRCKAMRCKA 0.807 0.185 -3 0.797
CK2A2CK2A2 0.807 0.089 1 0.682
CK1ECK1E 0.807 -0.052 -3 0.470
LKB1LKB1 0.806 0.076 -3 0.820
SNRKSNRK 0.806 -0.138 2 0.668
MEKK3MEKK3 0.806 -0.144 1 0.775
GCKGCK 0.806 0.100 1 0.783
ZAKZAK 0.806 -0.122 1 0.740
MEKK2MEKK2 0.805 -0.102 2 0.806
HRIHRI 0.804 -0.185 -2 0.843
ERK7ERK7 0.804 0.067 2 0.562
CDK4CDK4 0.804 0.163 1 0.711
DMPK1DMPK1 0.803 0.240 -3 0.804
PINK1PINK1 0.803 -0.150 1 0.834
TLK1TLK1 0.803 -0.119 -2 0.821
GRK3GRK3 0.803 -0.018 -2 0.675
CDK6CDK6 0.802 0.146 1 0.731
IRAK4IRAK4 0.802 -0.080 1 0.756
CHK2CHK2 0.802 0.123 -3 0.706
SSTKSSTK 0.801 -0.012 4 0.689
PHKG2PHKG2 0.801 -0.020 -3 0.821
HPK1HPK1 0.800 0.077 1 0.771
BUB1BUB1 0.800 0.179 -5 0.789
PDK1PDK1 0.799 -0.008 1 0.738
TNIKTNIK 0.799 0.064 3 0.841
CAMKK1CAMKK1 0.799 -0.090 -2 0.759
CAMKK2CAMKK2 0.799 -0.029 -2 0.758
CK2A1CK2A1 0.799 0.092 1 0.665
PKN1PKN1 0.799 0.072 -3 0.775
TAO2TAO2 0.798 -0.059 2 0.857
NEK11NEK11 0.798 -0.122 1 0.759
CK1DCK1D 0.798 -0.051 -3 0.414
CAMK1ACAMK1A 0.797 0.118 -3 0.723
CRIKCRIK 0.797 0.215 -3 0.778
CK1G1CK1G1 0.796 -0.087 -3 0.458
NEK8NEK8 0.795 -0.138 2 0.817
CK1A2CK1A2 0.795 -0.056 -3 0.417
KHS2KHS2 0.795 0.103 1 0.773
NEK4NEK4 0.795 -0.059 1 0.759
PBKPBK 0.795 0.126 1 0.775
PDHK3_TYRPDHK3_TYR 0.795 0.412 4 0.854
KHS1KHS1 0.795 0.078 1 0.753
HGKHGK 0.794 -0.017 3 0.837
NEK1NEK1 0.794 0.020 1 0.760
PLK2PLK2 0.794 -0.019 -3 0.728
LRRK2LRRK2 0.793 -0.047 2 0.850
MST2MST2 0.793 -0.073 1 0.780
LOKLOK 0.792 -0.002 -2 0.775
MEKK6MEKK6 0.792 -0.057 1 0.765
TAK1TAK1 0.792 -0.047 1 0.777
EEF2KEEF2K 0.792 -0.044 3 0.802
ROCK1ROCK1 0.792 0.180 -3 0.793
MINKMINK 0.792 -0.037 1 0.759
MAP3K15MAP3K15 0.792 -0.044 1 0.725
TTBK1TTBK1 0.791 -0.193 2 0.634
VRK1VRK1 0.790 -0.063 2 0.833
PKG1PKG1 0.788 0.100 -2 0.641
STK33STK33 0.787 -0.106 2 0.640
SLKSLK 0.787 -0.053 -2 0.724
IRAK1IRAK1 0.785 -0.287 -1 0.733
PDHK4_TYRPDHK4_TYR 0.785 0.208 2 0.900
MST1MST1 0.784 -0.102 1 0.759
YSK1YSK1 0.784 -0.038 2 0.811
HASPINHASPIN 0.783 0.071 -1 0.725
MAP2K4_TYRMAP2K4_TYR 0.782 0.132 -1 0.860
TESK1_TYRTESK1_TYR 0.782 0.103 3 0.872
MAP2K6_TYRMAP2K6_TYR 0.781 0.116 -1 0.853
LIMK2_TYRLIMK2_TYR 0.780 0.170 -3 0.879
PKMYT1_TYRPKMYT1_TYR 0.779 0.101 3 0.846
MEK2MEK2 0.779 -0.212 2 0.808
BIKEBIKE 0.778 0.096 1 0.754
BMPR2_TYRBMPR2_TYR 0.777 0.065 -1 0.844
MAP2K7_TYRMAP2K7_TYR 0.776 -0.039 2 0.870
OSR1OSR1 0.776 -0.068 2 0.806
YANK3YANK3 0.775 -0.042 2 0.435
PDHK1_TYRPDHK1_TYR 0.774 -0.000 -1 0.859
MYO3BMYO3B 0.774 -0.006 2 0.822
NEK3NEK3 0.773 -0.122 1 0.715
RIPK2RIPK2 0.773 -0.277 1 0.693
TTKTTK 0.773 -0.054 -2 0.820
EPHA6EPHA6 0.770 0.035 -1 0.822
PINK1_TYRPINK1_TYR 0.770 -0.130 1 0.803
EPHB4EPHB4 0.769 0.029 -1 0.806
ASK1ASK1 0.769 -0.112 1 0.711
AAK1AAK1 0.768 0.152 1 0.670
RETRET 0.767 -0.071 1 0.765
TAO1TAO1 0.766 -0.085 1 0.687
TXKTXK 0.765 0.098 1 0.805
LIMK1_TYRLIMK1_TYR 0.765 -0.098 2 0.850
TNK2TNK2 0.765 0.057 3 0.757
MYO3AMYO3A 0.764 -0.089 1 0.754
CK1ACK1A 0.764 -0.060 -3 0.323
ABL2ABL2 0.763 0.003 -1 0.790
MST1RMST1R 0.763 -0.118 3 0.799
DDR1DDR1 0.761 -0.109 4 0.758
FGRFGR 0.761 -0.052 1 0.829
EPHA4EPHA4 0.761 -0.009 2 0.816
ALPHAK3ALPHAK3 0.761 -0.121 -1 0.736
YES1YES1 0.760 -0.038 -1 0.826
TYRO3TYRO3 0.759 -0.126 3 0.779
SRMSSRMS 0.759 -0.011 1 0.808
ROS1ROS1 0.759 -0.122 3 0.755
ABL1ABL1 0.758 -0.029 -1 0.785
TYK2TYK2 0.758 -0.212 1 0.757
JAK2JAK2 0.757 -0.158 1 0.752
CSF1RCSF1R 0.757 -0.125 3 0.772
EPHB1EPHB1 0.756 -0.054 1 0.800
ITKITK 0.756 -0.023 -1 0.768
EPHB3EPHB3 0.755 -0.051 -1 0.792
BLKBLK 0.755 0.024 -1 0.808
TNK1TNK1 0.755 -0.012 3 0.767
FERFER 0.754 -0.158 1 0.823
INSRRINSRR 0.754 -0.114 3 0.737
LCKLCK 0.754 -0.012 -1 0.802
JAK3JAK3 0.754 -0.152 1 0.738
EPHB2EPHB2 0.753 -0.052 -1 0.786
FGFR2FGFR2 0.753 -0.129 3 0.789
HCKHCK 0.753 -0.094 -1 0.801
NEK10_TYRNEK10_TYR 0.752 -0.089 1 0.645
MERTKMERTK 0.752 -0.048 3 0.767
BMXBMX 0.752 -0.018 -1 0.703
TNNI3K_TYRTNNI3K_TYR 0.751 -0.033 1 0.772
DDR2DDR2 0.751 0.037 3 0.724
KDRKDR 0.750 -0.103 3 0.741
JAK1JAK1 0.750 -0.060 1 0.700
AXLAXL 0.750 -0.098 3 0.766
EPHA7EPHA7 0.750 -0.038 2 0.806
FYNFYN 0.749 0.007 -1 0.783
STLK3STLK3 0.749 -0.230 1 0.713
KITKIT 0.748 -0.164 3 0.771
PDGFRBPDGFRB 0.747 -0.204 3 0.784
METMET 0.747 -0.116 3 0.775
TEKTEK 0.746 -0.161 3 0.717
PTK2BPTK2B 0.746 -0.009 -1 0.759
EPHA3EPHA3 0.746 -0.103 2 0.780
TECTEC 0.745 -0.092 -1 0.717
WEE1_TYRWEE1_TYR 0.745 -0.103 -1 0.734
FGFR1FGFR1 0.743 -0.198 3 0.753
LTKLTK 0.743 -0.143 3 0.723
NTRK1NTRK1 0.742 -0.194 -1 0.794
EPHA1EPHA1 0.742 -0.110 3 0.750
EPHA5EPHA5 0.741 -0.061 2 0.799
FLT3FLT3 0.741 -0.250 3 0.771
FGFR3FGFR3 0.741 -0.154 3 0.760
FLT1FLT1 0.741 -0.149 -1 0.788
BTKBTK 0.741 -0.218 -1 0.743
ALKALK 0.741 -0.179 3 0.698
PTK6PTK6 0.738 -0.230 -1 0.707
ERBB2ERBB2 0.738 -0.199 1 0.721
PDGFRAPDGFRA 0.738 -0.279 3 0.781
LYNLYN 0.738 -0.118 3 0.701
PTK2PTK2 0.737 0.009 -1 0.736
NTRK3NTRK3 0.737 -0.146 -1 0.754
EPHA8EPHA8 0.737 -0.088 -1 0.773
FRKFRK 0.736 -0.153 -1 0.810
SRCSRC 0.736 -0.085 -1 0.787
INSRINSR 0.736 -0.196 3 0.718
MATKMATK 0.736 -0.135 -1 0.723
YANK2YANK2 0.734 -0.100 2 0.454
NTRK2NTRK2 0.734 -0.257 3 0.743
FLT4FLT4 0.734 -0.226 3 0.741
EGFREGFR 0.733 -0.113 1 0.634
CK1G3CK1G3 0.732 -0.115 -3 0.277
SYKSYK 0.731 -0.034 -1 0.735
CSKCSK 0.731 -0.163 2 0.802
EPHA2EPHA2 0.730 -0.074 -1 0.739
FGFR4FGFR4 0.729 -0.134 -1 0.743
ERBB4ERBB4 0.723 -0.086 1 0.667
CK1G2CK1G2 0.721 -0.093 -3 0.373
IGF1RIGF1R 0.721 -0.190 3 0.657
MUSKMUSK 0.719 -0.190 1 0.634
ZAP70ZAP70 0.708 -0.075 -1 0.668
FESFES 0.707 -0.177 -1 0.684