Motif 164 (n=241)

Position-wise Probabilities

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uniprot genes site source protein function
A1L390 PLEKHG3 S1028 ochoa Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}.
A5PKW4 PSD S990 ochoa PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1) Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). {ECO:0000250|UniProtKB:Q5DTT2, ECO:0000269|PubMed:23603394}.
A7E2V4 ZSWIM8 S1153 ochoa Zinc finger SWIM domain-containing protein 8 Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004). Plays an essential role for proper embryonic development of heart and lung (By similarity). Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q3UHH1, ECO:0000269|PubMed:24012004, ECO:0000269|PubMed:33184234, ECO:0000269|PubMed:33184237}.; FUNCTION: (Microbial infection) Participates in Zika virus inhibition of IFN signaling by acting as a scaffold protein to connect ZSWIM8/CUL3 ligase complex and STAT2, leading to STAT2 degradation. {ECO:0000269|PubMed:39145933}.
A7MCY6 TBKBP1 S349 ochoa TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269|PubMed:21931631}.
A8MYZ6 FOXO6 S215 ochoa Forkhead box protein O6 Transcriptional activator. {ECO:0000250}.
E9PAV3 NACA S193 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
O00221 NFKBIE S180 ochoa NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}.
O14497 ARID1A S763 ochoa AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:A2BH40, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O14545 TRAFD1 S468 ochoa TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}.
O14654 IRS4 S863 ochoa Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.
O14654 IRS4 S872 ochoa Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}.
O14733 MAP2K7 S61 ochoa Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.
O15164 TRIM24 S98 ochoa Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}.
O15211 RGL2 S737 ochoa Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.
O15265 ATXN7 S568 ochoa Ataxin-7 (Spinocerebellar ataxia type 7 protein) Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (PubMed:15932940, PubMed:18206972). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (PubMed:15932940, PubMed:18206972). Probably involved in tethering the deubiquitination module within the SAGA complex (PubMed:24493646). Necessary for microtubule cytoskeleton stabilization (PubMed:22100762). Involved in neurodegeneration (PubMed:9288099). {ECO:0000269|PubMed:15932940, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:22100762, ECO:0000269|PubMed:24493646, ECO:0000269|PubMed:9288099}.
O15357 INPPL1 S149 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}.
O15446 POLR1G S128 ochoa DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}.
O15504 NUP42 S310 ochoa Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. {ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:16000379}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope. {ECO:0000269|PubMed:12228227}.
O43166 SIPA1L1 S1078 ochoa Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43182 ARHGAP6 S777 ochoa Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}.
O43312 MTSS1 S644 ochoa Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
O43683 BUB1 S593 ochoa|psp Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:17158872, ECO:0000269|PubMed:19487456, ECO:0000269|PubMed:20739936, ECO:0000269|PubMed:35044816}.
O75037 KIF21B S520 ochoa Kinesin-like protein KIF21B Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}.
O75665 OFD1 S660 ochoa Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}.
O94880 PHF14 S147 ochoa PHD finger protein 14 Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity). {ECO:0000250|UniProtKB:A0A286Y9D1, ECO:0000250|UniProtKB:Q9D4H9, ECO:0000269|PubMed:23688586}.
O94967 WDR47 S569 ochoa WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) None
P04083 ANXA1 S34 ochoa|psp Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}.
P06733 ENO1 S263 ochoa Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
P08151 GLI1 S560 psp Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}.
P08913 ADRA2A S247 psp Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. {ECO:0000269|PubMed:23105096}.
P09619 PDGFRB S717 ochoa Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.
P0CG12 DERPC S293 ochoa Decreased expression in renal and prostate cancer protein Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
P13807 GYS1 S718 ochoa Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}.
P13861 PRKAR2A S58 ochoa cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
P14317 HCLS1 S300 ochoa Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
P17302 GJA1 S273 ochoa Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
P27815 PDE4A S830 ochoa 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}.
P27816 MAP4 S876 ochoa Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
P27987 ITPKB S22 ochoa Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
P28290 ITPRID2 S737 ochoa Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) None
P30530 AXL S875 ochoa Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}.
P35227 PCGF2 S260 ochoa Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). {ECO:0000250|UniProtKB:P23798, ECO:0000269|PubMed:26151332}.
P46087 NOP2 S58 ochoa 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
P46108 CRK S74 ochoa Adapter molecule crk (Proto-oncogene c-Crk) (p38) Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}.
P46937 YAP1 S274 ochoa|psp Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:16772533, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:25778702, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:30447097, ECO:0000269|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269|PubMed:12807903}.
P47974 ZFP36L2 S414 ochoa mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}.
P48436 SOX9 S231 ochoa Transcription factor SOX-9 Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:24038782). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:8640233). Also binds to some promoter regions (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (By similarity). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (By similarity). Controls epithelial branching during kidney development (By similarity). {ECO:0000250|UniProtKB:Q04887, ECO:0000269|PubMed:24038782, ECO:0000269|PubMed:8640233}.
P48634 PRRC2A S1115 ochoa Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}.
P49674 CSNK1E S354 ochoa Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}.
P49815 TSC2 S1152 ochoa Tuberin (Tuberous sclerosis 2 protein) Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}.
P49918 CDKN1C S288 ochoa Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
P51116 FXR2 S525 ochoa RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}.
P51825 AFF1 S203 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P51825 AFF1 S378 ochoa AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) None
P52597 HNRNPF S203 ochoa Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
P52948 NUP98 S1769 ochoa Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P53814 SMTN S357 ochoa Smoothelin Structural protein of the cytoskeleton.
P54278 PMS2 S436 ochoa Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}.
P55196 AFDN T1336 ochoa Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}.
P55201 BRPF1 S917 ochoa Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}.
P55884 EIF3B S83 ochoa Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P56524 HDAC4 S636 ochoa Histone deacetylase 4 (HD4) (EC 3.5.1.98) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}.
P56747 CLDN6 S201 ochoa Claudin-6 (Skullin) Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}.
P78347 GTF2I S207 ochoa General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}.
P78559 MAP1A S2126 ochoa Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
P80723 BASP1 S164 ochoa Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) None
P80723 BASP1 S177 ochoa Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) None
P80723 BASP1 S183 ochoa Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) None
P98174 FGD1 S235 ochoa FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}.
Q01196 RUNX1 S212 ochoa Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}.
Q01518 CAP1 S301 ochoa Adenylyl cyclase-associated protein 1 (CAP 1) Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Q05209 PTPN12 S323 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q05209 PTPN12 S517 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q07666 KHDRBS1 S24 ochoa KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.
Q07687 DLX2 S218 ochoa Homeobox protein DLX-2 Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}.
Q12888 TP53BP1 S1342 ochoa|psp TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q12912 IRAG2 S131 ochoa Inositol 1,4,5-triphosphate receptor associated 2 (Lymphoid-restricted membrane protein) (Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.
Q13094 LCP2 S339 ochoa Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells (PubMed:11313406, PubMed:33159816). Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK (PubMed:8673706, PubMed:8702662). In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation (PubMed:11313406). Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses (PubMed:33436632). {ECO:0000269|PubMed:11313406, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:8673706, ECO:0000269|PubMed:8702662}.
Q13177 PAK2 S141 ochoa|psp Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.
Q13191 CBLB S672 ochoa E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.
Q13283 G3BP1 S256 ochoa Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}.
Q13309 SKP2 S48 ochoa S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}.
Q13418 ILK S343 psp Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK) Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (PubMed:17420447, PubMed:20005845, PubMed:30367047, PubMed:32528174). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (PubMed:20005845). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (PubMed:16517730). Acts as an upstream effector of both AKT1/PKB and GSK3 (PubMed:9736715). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (PubMed:18283114). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (PubMed:17420447). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:16517730, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:18283114, ECO:0000269|PubMed:20005845, ECO:0000269|PubMed:30367047, ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:9736715}.
Q13428 TCOF1 S1267 ochoa Treacle protein (Treacher Collins syndrome protein) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.
Q13480 GAB1 S372 ochoa GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.
Q13796 SHROOM2 S123 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q13905 RAPGEF1 S214 ochoa Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}.
Q14157 UBAP2L S445 ochoa Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q14181 POLA2 S138 ochoa DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}.
Q14244 MAP7 S268 ochoa Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269|PubMed:11719555, ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}.
Q14247 CTTN S432 ochoa Src substrate cortactin (Amplaxin) (Oncogene EMS1) Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}.
Q14676 MDC1 S955 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14676 MDC1 S1086 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q14764 MVP S864 ochoa|psp Major vault protein (MVP) (Lung resistance-related protein) Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.
Q14774 HLX S91 ochoa H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.
Q14814 MEF2D S450 ochoa|psp Myocyte-specific enhancer factor 2D Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.
Q15003 NCAPH S78 ochoa Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}.
Q15643 TRIP11 S1882 ochoa Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. {ECO:0000269|PubMed:10189370, ECO:0000269|PubMed:25473115, ECO:0000269|PubMed:25717001, ECO:0000269|PubMed:30728324, ECO:0000269|PubMed:9256431}.
Q15648 MED1 S1207 ochoa|psp Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
Q15906 VPS72 S244 ochoa Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}.
Q15942 ZYX S170 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q15942 ZYX S258 ochoa Zyxin (Zyxin-2) Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.
Q16513 PKN2 S535 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q16799 RTN1 S330 ochoa Reticulon-1 (Neuroendocrine-specific protein) Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
Q3KQU3 MAP7D1 S457 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q3KQU3 MAP7D1 S576 ochoa MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}.
Q4KMQ1 TPRN S258 ochoa Taperin Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}.
Q4VC44 FLYWCH1 S192 ochoa FLYWCH-type zinc finger-containing protein 1 Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}.
Q5JTV8 TOR1AIP1 S39 ochoa Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}.
Q5PRF9 SAMD4B S243 ochoa Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B) Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. {ECO:0000269|PubMed:20510020}.
Q5SXM2 SNAPC4 T617 ochoa snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
Q5SYE7 NHSL1 S930 ochoa NHS-like protein 1 None
Q5VST9 OBSCN S7023 ochoa Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q5VT52 RPRD2 S476 ochoa Regulation of nuclear pre-mRNA domain-containing protein 2 None
Q63HK3 ZKSCAN2 S591 ochoa Zinc finger protein with KRAB and SCAN domains 2 (Zinc finger protein 694) May be involved in transcriptional regulation.
Q66K14 TBC1D9B S411 ochoa TBC1 domain family member 9B May act as a GTPase-activating protein for Rab family protein(s).
Q68CZ2 TNS3 S361 ochoa Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}.
Q68D20 PMS2CL S50 ochoa Protein PMS2CL (PMS2-C terminal-like protein) None
Q68DC2 ANKS6 S688 ochoa Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) Required for renal function. {ECO:0000269|PubMed:23793029}.
Q68DK7 MSL1 S393 ochoa Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}.
Q6IN85 PPP4R3A S768 ochoa Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
Q6IQ23 PLEKHA7 S536 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6IQ23 PLEKHA7 S858 ochoa Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:30463011}.
Q6UUV9 CRTC1 S158 ochoa CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}.
Q6UUV9 CRTC1 S215 psp CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}.
Q765P7 MTSS2 S579 ochoa Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}.
Q76L83 ASXL2 S1291 ochoa Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250|UniProtKB:Q8BZ32, ECO:0000269|PubMed:21047783, ECO:0000269|PubMed:30664650, ECO:0000269|PubMed:36180891}.
Q76N32 CEP68 S226 ochoa Centrosomal protein of 68 kDa (Cep68) Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564). Contributes to CROCC/rootletin filament formation (PubMed:30404835). {ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:24554434, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:30404835}.
Q7LDG7 RASGRP2 S391 ochoa RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein) Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269|PubMed:10918068, ECO:0000269|PubMed:14702343, ECO:0000269|PubMed:17576779, ECO:0000269|PubMed:17702895, ECO:0000269|PubMed:24958846, ECO:0000269|PubMed:27235135}.
Q7Z2Z1 TICRR S1352 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z6Z7 HUWE1 S2735 ochoa E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}.
Q86UR5 RIMS1 S448 ochoa Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.
Q86UU0 BCL9L S959 ochoa B-cell CLL/lymphoma 9-like protein (B-cell lymphoma 9-like protein) (BCL9-like protein) (Protein BCL9-2) Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
Q8IU81 IRF2BP1 S436 ochoa Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}.
Q8IWZ8 SUGP1 S326 ochoa SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) Plays a role in pre-mRNA splicing.
Q8IWZ8 SUGP1 S344 ochoa SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4) Plays a role in pre-mRNA splicing.
Q8IX03 WWC1 S539 psp Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}.
Q8IX12 CCAR1 S214 ochoa Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
Q8IY92 SLX4 S1342 ochoa Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.
Q8IYT8 ULK2 S771 ochoa Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}.
Q8IZD4 DCP1B S559 ochoa mRNA-decapping enzyme 1B (EC 3.6.1.62) May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}.
Q8IZW8 TNS4 S404 ochoa Tensin-4 (C-terminal tensin-like protein) Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration (PubMed:17643115). Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF (PubMed:23774213). Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration (PubMed:24814316). {ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:23774213, ECO:0000269|PubMed:24814316}.
Q8N0Y2 ZNF444 S232 ochoa Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter.
Q8N1G0 ZNF687 S174 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N1G0 ZNF687 S1182 ochoa Zinc finger protein 687 May be involved in transcriptional regulation.
Q8N1G4 LRRC47 S528 ochoa Leucine-rich repeat-containing protein 47 None
Q8N201 INTS1 S1318 ochoa Integrator complex subunit 1 (Int1) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q8N2Y8 RUSC2 S772 ochoa AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000269|PubMed:30262884}.
Q8N3V7 SYNPO S743 ochoa Synaptopodin Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}.
Q8N6N3 C1orf52 S65 ochoa UPF0690 protein C1orf52 (BCL10-associated gene protein) None
Q8N6S5 ARL6IP6 S71 ochoa ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1) None
Q8N8Z6 DCBLD1 S695 ochoa|psp Discoidin, CUB and LCCL domain-containing protein 1 None
Q8NBX0 SCCPDH S217 ochoa Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) None
Q8ND04 SMG8 S586 ochoa Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}.
Q8NDX5 PHC3 S653 ochoa Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}.
Q8NEZ4 KMT2C S2937 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NFH5 NUP35 S135 ochoa Nucleoporin NUP35 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. {ECO:0000269|PubMed:15703211}.
Q8NI35 PATJ S333 ochoa InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.
Q8TCT7 SPPL2B S511 ochoa Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}.
Q8TD55 PLEKHO2 S273 ochoa Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) None
Q8TDM6 DLG5 S972 ochoa Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250|UniProtKB:E9Q9R9, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:28169360}.
Q8TDY2 RB1CC1 S644 ochoa RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}.
Q8TEQ6 GEMIN5 S621 ochoa Gem-associated protein 5 (Gemin5) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.
Q8TEW8 PARD3B S352 ochoa Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Q8WUF5 PPP1R13L S53 ochoa RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}.
Q8WUI4 HDAC7 S487 ochoa Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}.
Q8WUM4 PDCD6IP S721 psp Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}.
Q8WUM4 PDCD6IP Y727 ochoa Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17556548, PubMed:17853893). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17556548, PubMed:17853893, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). {ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:22660413}.; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}.
Q8WWI1 LMO7 S910 ochoa LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) None
Q8WX93 PALLD S632 ochoa Palladin (SIH002) (Sarcoma antigen NY-SAR-77) Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}.
Q8WYQ5 DGCR8 S368 ochoa Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250|UniProtKB:Q9EQM6, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:16963499, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:25799998, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.
Q92610 ZNF592 S322 ochoa Zinc finger protein 592 May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}.
Q92619 ARHGAP45 S90 ochoa Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}.
Q92835 INPP5D S951 ochoa Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}.
Q93052 LPP S135 ochoa Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma) May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.
Q969V6 MRTFA S124 ochoa Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}.
Q969V6 MRTFA S794 ochoa Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}.
Q96B67 ARRDC3 S395 ochoa Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}.
Q96BT3 CENPT S201 ochoa|psp Centromere protein T (CENP-T) (Interphase centromere complex protein 22) Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.
Q96E09 PABIR1 S267 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96E39 RBMXL1 S291 ochoa RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}.
Q96HA1 POM121 S715 ochoa Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa) Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). {ECO:0000269|PubMed:17900573}.
Q96JM3 CHAMP1 S244 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96MY1 NOL4L S391 ochoa Nucleolar protein 4-like None
Q96RG2 PASK S120 ochoa PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.
Q96S59 RANBP9 Y474 ochoa Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7) May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. {ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:18710924, ECO:0000269|PubMed:29911972, ECO:0000305}.
Q96S99 PLEKHF1 S227 ochoa Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15) May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.
Q96T58 SPEN S3138 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q9BQ52 ELAC2 S199 ochoa Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:24703694}.
Q9BQ67 GRWD1 S25 ochoa Glutamate-rich WD repeat-containing protein 1 Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.
Q9BW85 YJU2 S220 ochoa Splicing factor YJU2 (Coiled-coil domain-containing protein 94) Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453). {ECO:0000255|HAMAP-Rule:MF_03226, ECO:0000269|PubMed:22952453, ECO:0000269|PubMed:29301961}.
Q9BZI1 IRX2 S317 ochoa Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) None
Q9C0B5 ZDHHC5 S554 ochoa Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}.
Q9C0K0 BCL11B S257 ochoa B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.
Q9H0E9 BRD8 S582 ochoa Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.
Q9H0F6 SHARPIN S131 ochoa|psp Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9H3M7 TXNIP S358 ochoa Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Q9H4G0 EPB41L1 S541 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H4M7 PLEKHA4 S164 ochoa Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1) Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. {ECO:0000269|PubMed:11001876}.
Q9H5Z6 FAM124B S294 ochoa Protein FAM124B None
Q9H7M9 VSIR S287 ochoa V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor) Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.
Q9H7N4 SCAF1 S659 ochoa Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) May function in pre-mRNA splicing. {ECO:0000250}.
Q9H7P9 PLEKHG2 S1254 ochoa Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2) May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
Q9H9A7 RMI1 S283 ochoa RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.
Q9H9J4 USP42 S856 ochoa Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9HAH7 FBRS S210 ochoa Probable fibrosin-1 None
Q9HCD6 TANC2 S1434 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9NQ84 GPRC5C S344 ochoa G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3) This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. {ECO:0000250}.
Q9NQS7 INCENP S202 ochoa Inner centromere protein Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}.
Q9NRR5 UBQLN4 S98 ochoa Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (PubMed:15280365, PubMed:27113755, PubMed:29666234, PubMed:30612738). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (PubMed:15280365, PubMed:27113755, PubMed:30612738). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome (PubMed:30612738). MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) (PubMed:30612738). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation (PubMed:27113755). Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery (PubMed:23459205). Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:27113755, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}.
Q9NUQ6 SPATS2L S362 ochoa SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) None
Q9NX94 WBP1L S167 ochoa WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) None
Q9NX94 WBP1L S173 ochoa WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) None
Q9NYF8 BCLAF1 Y219 ochoa Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Q9NYQ6 CELSR1 S2784 ochoa Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2) Receptor that may have an important role in cell/cell signaling during nervous system formation.
Q9NZB2 FAM120A S435 ochoa Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}.
Q9P1Y5 CAMSAP3 S193 ochoa Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.
Q9P206 NHSL3 S832 ochoa NHS-like protein 3 Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}.
Q9P266 JCAD S983 ochoa Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) None
Q9P2B4 CTTNBP2NL S514 ochoa CTTNBP2 N-terminal-like protein Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250|UniProtKB:Q8SX68, ECO:0000269|PubMed:18782753}.
Q9P2E9 RRBP1 S1277 ochoa Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
Q9UEY8 ADD3 S478 ochoa Gamma-adducin (Adducin-like protein 70) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250|UniProtKB:Q62847, ECO:0000250|UniProtKB:Q9QYB5, ECO:0000269|PubMed:23836506, ECO:0000305}.
Q9UKJ3 GPATCH8 S526 ochoa G patch domain-containing protein 8 None
Q9ULQ1 TPCN1 S796 ochoa Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946). {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:23394946, ECO:0000269|PubMed:24776928, ECO:0000305|PubMed:32679067}.; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. {ECO:0000269|PubMed:25722412}.
Q9ULX9 MAFF S146 ochoa Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}.
Q9UM54 MYO6 Y1146 ochoa Unconventional myosin-VI (Unconventional myosin-6) Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Required for the correct localization of CLIC5 and RDX at the stereocilium base (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:29467281, ECO:0000269|PubMed:31371777}.
Q9UMS6 SYNPO2 S595 ochoa Synaptopodin-2 (Genethonin-2) (Myopodin) Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:23225103, PubMed:24005909). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.
Q9UPN3 MACF1 S6967 ochoa Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.
Q9UPU7 TBC1D2B S152 ochoa TBC1 domain family member 2B GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}.
Q9UQ35 SRRM2 S395 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ35 SRRM2 S2314 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQL6 HDAC5 S662 ochoa Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.
Q9Y2X7 GIT1 S508 ochoa|psp ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}.
Q9Y3F4 STRAP S219 ochoa Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.
Q9Y490 TLN1 S446 ochoa|psp Talin-1 High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}.
Q9Y4F1 FARP1 S424 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y5S2 CDC42BPB S1690 ochoa|psp Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q9Y6A5 TACC3 S570 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q9H7L9 SUDS3 S228 SIGNOR Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog) Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.
Q01518 CAP1 S25 Sugiyama Adenylyl cyclase-associated protein 1 (CAP 1) Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Q8N5S9 CAMKK1 Y91 Sugiyama Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}.
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reactome_id name p -log10_p
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.000027 4.573
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.000031 4.507
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.000031 4.507
R-HSA-1855170 IPs transport between nucleus and cytosol 0.000042 4.381
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.000042 4.381
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.000048 4.321
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.000048 4.321
R-HSA-180746 Nuclear import of Rev protein 0.000055 4.262
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.000062 4.205
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.000102 3.991
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.000115 3.940
R-HSA-194441 Metabolism of non-coding RNA 0.000107 3.970
R-HSA-191859 snRNP Assembly 0.000107 3.970
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.000080 4.095
R-HSA-177243 Interactions of Rev with host cellular proteins 0.000115 3.940
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.000115 3.940
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.000091 4.042
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.000102 3.991
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.000129 3.891
R-HSA-6784531 tRNA processing in the nucleus 0.000140 3.854
R-HSA-1483249 Inositol phosphate metabolism 0.000180 3.746
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.000218 3.661
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.000241 3.618
R-HSA-2980766 Nuclear Envelope Breakdown 0.000636 3.197
R-HSA-211000 Gene Silencing by RNA 0.000671 3.173
R-HSA-8875878 MET promotes cell motility 0.000797 3.098
R-HSA-168325 Viral Messenger RNA Synthesis 0.000864 3.064
R-HSA-350054 Notch-HLH transcription pathway 0.001080 2.966
R-HSA-8875555 MET activates RAP1 and RAC1 0.001207 2.918
R-HSA-162582 Signal Transduction 0.001258 2.900
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.001504 2.823
R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 0.001887 2.724
R-HSA-5578749 Transcriptional regulation by small RNAs 0.001820 2.740
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.001936 2.713
R-HSA-70171 Glycolysis 0.002060 2.686
R-HSA-1169408 ISG15 antiviral mechanism 0.002184 2.661
R-HSA-8875513 MET interacts with TNS proteins 0.002918 2.535
R-HSA-6806834 Signaling by MET 0.002909 2.536
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.003245 2.489
R-HSA-9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 0.004159 2.381
R-HSA-70326 Glucose metabolism 0.005061 2.296
R-HSA-9705683 SARS-CoV-2-host interactions 0.006398 2.194
R-HSA-162909 Host Interactions of HIV factors 0.006652 2.177
R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.007243 2.140
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.008352 2.078
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 0.008411 2.075
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... 0.009074 2.042
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.009470 2.024
R-HSA-76009 Platelet Aggregation (Plug Formation) 0.010242 1.990
R-HSA-1640170 Cell Cycle 0.011850 1.926
R-HSA-68886 M Phase 0.012147 1.916
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.012158 1.915
R-HSA-69278 Cell Cycle, Mitotic 0.012184 1.914
R-HSA-8875656 MET receptor recycling 0.013279 1.877
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.014085 1.851
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.013058 1.884
R-HSA-162599 Late Phase of HIV Life Cycle 0.014085 1.851
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.014484 1.839
R-HSA-190873 Gap junction degradation 0.015642 1.806
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.017175 1.765
R-HSA-141424 Amplification of signal from the kinetochores 0.017175 1.765
R-HSA-9619229 Activation of RAC1 downstream of NMDARs 0.015642 1.806
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.018171 1.741
R-HSA-68877 Mitotic Prometaphase 0.019976 1.699
R-HSA-68875 Mitotic Prophase 0.020166 1.695
R-HSA-186763 Downstream signal transduction 0.021156 1.675
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.024222 1.616
R-HSA-354192 Integrin signaling 0.024222 1.616
R-HSA-186797 Signaling by PDGF 0.025421 1.595
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.024222 1.616
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.023185 1.635
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.023185 1.635
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.023185 1.635
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.023185 1.635
R-HSA-3371556 Cellular response to heat stress 0.020821 1.682
R-HSA-162587 HIV Life Cycle 0.021736 1.663
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.023185 1.635
R-HSA-8951936 RUNX3 regulates p14-ARF 0.026696 1.574
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.030936 1.510
R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 0.030936 1.510
R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 0.030936 1.510
R-HSA-3214847 HATs acetylate histones 0.030932 1.510
R-HSA-74160 Gene expression (Transcription) 0.028902 1.539
R-HSA-8878159 Transcriptional regulation by RUNX3 0.028924 1.539
R-HSA-4839726 Chromatin organization 0.027729 1.557
R-HSA-72306 tRNA processing 0.031121 1.507
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.029012 1.537
R-HSA-69618 Mitotic Spindle Checkpoint 0.031968 1.495
R-HSA-9694516 SARS-CoV-2 Infection 0.033079 1.480
R-HSA-69620 Cell Cycle Checkpoints 0.033133 1.480
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.036515 1.438
R-HSA-446353 Cell-extracellular matrix interactions 0.036515 1.438
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.036733 1.435
R-HSA-9690406 Transcriptional regulation of testis differentiation 0.043713 1.359
R-HSA-169893 Prolonged ERK activation events 0.040052 1.397
R-HSA-9708530 Regulation of BACH1 activity 0.040052 1.397
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.043525 1.361
R-HSA-162906 HIV Infection 0.043042 1.366
R-HSA-9020591 Interleukin-12 signaling 0.044642 1.350
R-HSA-1980143 Signaling by NOTCH1 0.044642 1.350
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.045459 1.342
R-HSA-190827 Transport of connexins along the secretory pathway 0.046045 1.337
R-HSA-9636667 Manipulation of host energy metabolism 0.046045 1.337
R-HSA-190704 Oligomerization of connexins into connexons 0.046045 1.337
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.047493 1.323
R-HSA-2028269 Signaling by Hippo 0.047493 1.323
R-HSA-5210891 Uptake and function of anthrax toxins 0.047493 1.323
R-HSA-3247509 Chromatin modifying enzymes 0.049170 1.308
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.059502 1.225
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.053456 1.272
R-HSA-3928664 Ephrin signaling 0.051387 1.289
R-HSA-912631 Regulation of signaling by CBL 0.055392 1.257
R-HSA-9855142 Cellular responses to mechanical stimuli 0.050133 1.300
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.057189 1.243
R-HSA-9831926 Nephron development 0.051387 1.289
R-HSA-157118 Signaling by NOTCH 0.054853 1.261
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.055928 1.252
R-HSA-9610379 HCMV Late Events 0.059763 1.224
R-HSA-8878166 Transcriptional regulation by RUNX2 0.060321 1.220
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.060919 1.215
R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.060919 1.215
R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.060919 1.215
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.060919 1.215
R-HSA-9708296 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 0.060919 1.215
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.063433 1.198
R-HSA-447115 Interleukin-12 family signaling 0.066122 1.180
R-HSA-6794361 Neurexins and neuroligins 0.069724 1.157
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 0.075562 1.122
R-HSA-8865999 MET activates PTPN11 0.075562 1.122
R-HSA-191650 Regulation of gap junction activity 0.089977 1.046
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.089977 1.046
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 0.104169 0.982
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 0.104169 0.982
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 0.118140 0.928
R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 0.131894 0.880
R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 0.131894 0.880
R-HSA-8851907 MET activates PI3K/AKT signaling 0.145435 0.837
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... 0.158765 0.799
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.158765 0.799
R-HSA-9028335 Activated NTRK2 signals through PI3K 0.158765 0.799
R-HSA-196025 Formation of annular gap junctions 0.158765 0.799
R-HSA-170984 ARMS-mediated activation 0.171888 0.765
R-HSA-68952 DNA replication initiation 0.184807 0.733
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.210046 0.678
R-HSA-69091 Polymerase switching 0.222372 0.653
R-HSA-69109 Leading Strand Synthesis 0.222372 0.653
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.234506 0.630
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.234506 0.630
R-HSA-69166 Removal of the Flap Intermediate 0.246452 0.608
R-HSA-9027284 Erythropoietin activates RAS 0.258212 0.588
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.269790 0.569
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.269790 0.569
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.281187 0.551
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.292407 0.534
R-HSA-180292 GAB1 signalosome 0.303453 0.518
R-HSA-5654710 PI-3K cascade:FGFR3 0.314327 0.503
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.314327 0.503
R-HSA-5654720 PI-3K cascade:FGFR4 0.325031 0.488
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.325031 0.488
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.325031 0.488
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.325031 0.488
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.325031 0.488
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.335570 0.474
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.306737 0.513
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.306737 0.513
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.318234 0.497
R-HSA-8854518 AURKA Activation by TPX2 0.323966 0.490
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 0.335392 0.474
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 0.090893 1.041
R-HSA-8878171 Transcriptional regulation by RUNX1 0.192817 0.715
R-HSA-69186 Lagging Strand Synthesis 0.335570 0.474
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.188915 0.724
R-HSA-72163 mRNA Splicing - Major Pathway 0.245122 0.611
R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 0.145435 0.837
R-HSA-69183 Processive synthesis on the lagging strand 0.258212 0.588
R-HSA-5693537 Resolution of D-Loop Structures 0.131202 0.882
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocy... 0.158765 0.799
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.222372 0.653
R-HSA-9796292 Formation of axial mesoderm 0.234506 0.630
R-HSA-174430 Telomere C-strand synthesis initiation 0.258212 0.588
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.125959 0.900
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.281187 0.551
R-HSA-163615 PKA activation 0.303453 0.518
R-HSA-157858 Gap junction trafficking and regulation 0.225821 0.646
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.158765 0.799
R-HSA-420029 Tight junction interactions 0.086155 1.065
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.110555 0.956
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.281187 0.551
R-HSA-190872 Transport of connexons to the plasma membrane 0.303453 0.518
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.335570 0.474
R-HSA-190828 Gap junction trafficking 0.197221 0.705
R-HSA-202433 Generation of second messenger molecules 0.169134 0.772
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.329685 0.482
R-HSA-72172 mRNA Splicing 0.277569 0.557
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.138502 0.859
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.246452 0.608
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.283645 0.547
R-HSA-69231 Cyclin D associated events in G1 0.197221 0.705
R-HSA-69236 G1 Phase 0.197221 0.705
R-HSA-5693607 Processing of DNA double-strand break ends 0.165690 0.781
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 0.222372 0.653
R-HSA-427413 NoRC negatively regulates rRNA expression 0.352421 0.453
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.246452 0.608
R-HSA-2871796 FCERI mediated MAPK activation 0.309253 0.510
R-HSA-5358508 Mismatch Repair 0.303453 0.518
R-HSA-5693538 Homology Directed Repair 0.155737 0.808
R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 0.089977 1.046
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.234506 0.630
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.258212 0.588
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.292407 0.534
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.303453 0.518
R-HSA-164378 PKA activation in glucagon signalling 0.303453 0.518
R-HSA-3322077 Glycogen synthesis 0.325031 0.488
R-HSA-5693532 DNA Double-Strand Break Repair 0.282594 0.549
R-HSA-9006335 Signaling by Erythropoietin 0.105540 0.977
R-HSA-5693606 DNA Double Strand Break Response 0.329685 0.482
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.292407 0.534
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.338936 0.470
R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 0.104169 0.982
R-HSA-1963642 PI3K events in ERBB2 signaling 0.292407 0.534
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.303453 0.518
R-HSA-111931 PKA-mediated phosphorylation of CREB 0.335570 0.474
R-HSA-9932451 SWI/SNF chromatin remodelers 0.086155 1.065
R-HSA-9932444 ATP-dependent chromatin remodelers 0.086155 1.065
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 0.120768 0.918
R-HSA-9675126 Diseases of mitotic cell cycle 0.120768 0.918
R-HSA-3229121 Glycogen storage diseases 0.292407 0.534
R-HSA-5632684 Hedgehog 'on' state 0.352421 0.453
R-HSA-445355 Smooth Muscle Contraction 0.072461 1.140
R-HSA-5357905 Regulation of TNFR1 signaling 0.208613 0.681
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 0.314327 0.503
R-HSA-9734767 Developmental Cell Lineages 0.287085 0.542
R-HSA-5610787 Hedgehog 'off' state 0.099202 1.003
R-HSA-5655302 Signaling by FGFR1 in disease 0.180290 0.744
R-HSA-5423599 Diseases of Mismatch Repair (MMR) 0.075562 1.122
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.210046 0.678
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 0.234506 0.630
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.281187 0.551
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.335570 0.474
R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.335570 0.474
R-HSA-75893 TNF signaling 0.266278 0.575
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.220071 0.657
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 0.158765 0.799
R-HSA-453276 Regulation of mitotic cell cycle 0.352421 0.453
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.352421 0.453
R-HSA-5358351 Signaling by Hedgehog 0.228100 0.642
R-HSA-114608 Platelet degranulation 0.186100 0.730
R-HSA-111933 Calmodulin induced events 0.147216 0.832
R-HSA-438064 Post NMDA receptor activation events 0.192866 0.715
R-HSA-8941284 RUNX2 regulates chondrocyte maturation 0.104169 0.982
R-HSA-428890 Role of ABL in ROBO-SLIT signaling 0.145435 0.837
R-HSA-201688 WNT mediated activation of DVL 0.171888 0.765
R-HSA-198693 AKT phosphorylates targets in the nucleus 0.171888 0.765
R-HSA-428540 Activation of RAC1 0.210046 0.678
R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.222372 0.653
R-HSA-180024 DARPP-32 events 0.105540 0.977
R-HSA-399719 Trafficking of AMPA receptors 0.115633 0.937
R-HSA-187687 Signalling to ERKs 0.141833 0.848
R-HSA-111997 CaM pathway 0.147216 0.832
R-HSA-113510 E2F mediated regulation of DNA replication 0.314327 0.503
R-HSA-69473 G2/M DNA damage checkpoint 0.139792 0.855
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.161906 0.791
R-HSA-68882 Mitotic Anaphase 0.081006 1.091
R-HSA-2428928 IRS-related events triggered by IGF1R 0.295205 0.530
R-HSA-2467813 Separation of Sister Chromatids 0.160662 0.794
R-HSA-76002 Platelet activation, signaling and aggregation 0.094794 1.023
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.082393 1.084
R-HSA-177929 Signaling by EGFR 0.266278 0.575
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.184807 0.733
R-HSA-202403 TCR signaling 0.300726 0.522
R-HSA-111996 Ca-dependent events 0.185910 0.731
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.323966 0.490
R-HSA-8941326 RUNX2 regulates bone development 0.147216 0.832
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 0.136494 0.865
R-HSA-1489509 DAG and IP3 signaling 0.202908 0.693
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.208404 0.681
R-HSA-212436 Generic Transcription Pathway 0.155294 0.809
R-HSA-9675135 Diseases of DNA repair 0.208613 0.681
R-HSA-73857 RNA Polymerase II Transcription 0.130003 0.886
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.330595 0.481
R-HSA-164944 Nef and signal transduction 0.131894 0.880
R-HSA-9614399 Regulation of localization of FOXO transcription factors 0.197525 0.704
R-HSA-8851805 MET activates RAS signaling 0.222372 0.653
R-HSA-5655291 Signaling by FGFR4 in disease 0.246452 0.608
R-HSA-8943724 Regulation of PTEN gene transcription 0.092911 1.032
R-HSA-9665348 Signaling by ERBB2 ECD mutants 0.303453 0.518
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.161906 0.791
R-HSA-112043 PLC beta mediated events 0.295205 0.530
R-HSA-9707564 Cytoprotection by HMOX1 0.173336 0.761
R-HSA-9860931 Response of endothelial cells to shear stress 0.109113 0.962
R-HSA-2428924 IGF1R signaling cascade 0.312491 0.505
R-HSA-8953854 Metabolism of RNA 0.192830 0.715
R-HSA-73887 Death Receptor Signaling 0.136401 0.865
R-HSA-390696 Adrenoceptors 0.158765 0.799
R-HSA-912526 Interleukin receptor SHC signaling 0.076918 1.114
R-HSA-389359 CD28 dependent Vav1 pathway 0.234506 0.630
R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.292407 0.534
R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.292407 0.534
R-HSA-844456 The NLRP3 inflammasome 0.314327 0.503
R-HSA-9609690 HCMV Early Events 0.125317 0.902
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.318234 0.497
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.128292 0.892
R-HSA-170968 Frs2-mediated activation 0.234506 0.630
R-HSA-9659379 Sensory processing of sound 0.158149 0.801
R-HSA-6794362 Protein-protein interactions at synapses 0.181080 0.742
R-HSA-112040 G-protein mediated events 0.329685 0.482
R-HSA-9010642 ROBO receptors bind AKAP5 0.158765 0.799
R-HSA-210990 PECAM1 interactions 0.197525 0.704
R-HSA-525793 Myogenesis 0.090893 1.041
R-HSA-193648 NRAGE signals death through JNK 0.080954 1.092
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.152640 0.816
R-HSA-392517 Rap1 signalling 0.314327 0.503
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.118815 0.925
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.155737 0.808
R-HSA-9909396 Circadian clock 0.205171 0.688
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 0.262584 0.581
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.335570 0.474
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.335570 0.474
R-HSA-1227986 Signaling by ERBB2 0.289428 0.538
R-HSA-9609646 HCMV Infection 0.252691 0.597
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.145435 0.837
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 0.222372 0.653
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.269790 0.569
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.266278 0.575
R-HSA-5689880 Ub-specific processing proteases 0.186529 0.729
R-HSA-111885 Opioid Signalling 0.271015 0.567
R-HSA-9819196 Zygotic genome activation (ZGA) 0.335570 0.474
R-HSA-1227990 Signaling by ERBB2 in Cancer 0.110555 0.956
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.076918 1.114
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.222372 0.653
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 0.222372 0.653
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.125959 0.900
R-HSA-9006925 Intracellular signaling by second messengers 0.119803 0.922
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.234506 0.630
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.301694 0.520
R-HSA-373755 Semaphorin interactions 0.306737 0.513
R-HSA-8848021 Signaling by PTK6 0.306737 0.513
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.306737 0.513
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 0.110555 0.956
R-HSA-5688426 Deubiquitination 0.265787 0.575
R-HSA-168255 Influenza Infection 0.094237 1.026
R-HSA-9012852 Signaling by NOTCH3 0.078077 1.107
R-HSA-9707616 Heme signaling 0.099147 1.004
R-HSA-446728 Cell junction organization 0.191270 0.718
R-HSA-166520 Signaling by NTRKs 0.265313 0.576
R-HSA-9008059 Interleukin-37 signaling 0.110555 0.956
R-HSA-1257604 PIP3 activates AKT signaling 0.228895 0.640
R-HSA-416482 G alpha (12/13) signalling events 0.154419 0.811
R-HSA-3700989 Transcriptional Regulation by TP53 0.236848 0.626
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.334005 0.476
R-HSA-1500931 Cell-Cell communication 0.278469 0.555
R-HSA-9945266 Differentiation of T cells 0.269790 0.569
R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) 0.269790 0.569
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.165690 0.781
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.099147 1.004
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.136212 0.866
R-HSA-1592230 Mitochondrial biogenesis 0.339132 0.470
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.346761 0.460
R-HSA-8953897 Cellular responses to stimuli 0.215923 0.666
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.197221 0.705
R-HSA-5339562 Uptake and actions of bacterial toxins 0.243127 0.614
R-HSA-9830369 Kidney development 0.329685 0.482
R-HSA-8953750 Transcriptional Regulation by E2F6 0.163601 0.786
R-HSA-1483255 PI Metabolism 0.262584 0.581
R-HSA-9679506 SARS-CoV Infections 0.123886 0.907
R-HSA-193704 p75 NTR receptor-mediated signalling 0.250003 0.602
R-HSA-449147 Signaling by Interleukins 0.219086 0.659
R-HSA-451927 Interleukin-2 family signaling 0.169134 0.772
R-HSA-5619102 SLC transporter disorders 0.073652 1.133
R-HSA-5619115 Disorders of transmembrane transporters 0.244923 0.611
R-HSA-5654689 PI-3K cascade:FGFR1 0.356157 0.448
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.356157 0.448
R-HSA-6803529 FGFR2 alternative splicing 0.356157 0.448
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.356157 0.448
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.356157 0.448
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.356157 0.448
R-HSA-1280215 Cytokine Signaling in Immune system 0.361029 0.442
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.363584 0.439
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.363691 0.439
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.366212 0.436
R-HSA-2262752 Cellular responses to stress 0.368982 0.433
R-HSA-1226099 Signaling by FGFR in disease 0.369298 0.433
R-HSA-380287 Centrosome maturation 0.374886 0.426
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.376109 0.425
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.376109 0.425
R-HSA-194138 Signaling by VEGF 0.377409 0.423
R-HSA-5654695 PI-3K cascade:FGFR2 0.385853 0.414
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.385853 0.414
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.385853 0.414
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.385853 0.414
R-HSA-69481 G2/M Checkpoints 0.385862 0.414
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.390079 0.409
R-HSA-9703465 Signaling by FLT3 fusion proteins 0.395446 0.403
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.395446 0.403
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.395446 0.403
R-HSA-1643713 Signaling by EGFR in Cancer 0.395446 0.403
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.395446 0.403
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.397029 0.401
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.402509 0.395
R-HSA-5654738 Signaling by FGFR2 0.402509 0.395
R-HSA-73863 RNA Polymerase I Transcription Termination 0.404889 0.393
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 0.404889 0.393
R-HSA-5655332 Signaling by FGFR3 in disease 0.404889 0.393
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.404889 0.393
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.414185 0.383
R-HSA-622312 Inflammasomes 0.414185 0.383
R-HSA-421270 Cell-cell junction organization 0.421811 0.375
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.423336 0.373
R-HSA-5654708 Downstream signaling of activated FGFR3 0.423336 0.373
R-HSA-9664565 Signaling by ERBB2 KD Mutants 0.423336 0.373
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.424187 0.372
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.424187 0.372
R-HSA-6802957 Oncogenic MAPK signaling 0.429543 0.367
R-HSA-2424491 DAP12 signaling 0.432345 0.364
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.432345 0.364
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.432345 0.364
R-HSA-5654716 Downstream signaling of activated FGFR4 0.432345 0.364
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.432345 0.364
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.432345 0.364
R-HSA-68962 Activation of the pre-replicative complex 0.432345 0.364
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.432345 0.364
R-HSA-8863795 Downregulation of ERBB2 signaling 0.432345 0.364
R-HSA-381038 XBP1(S) activates chaperone genes 0.440177 0.356
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.441214 0.355
R-HSA-162588 Budding and maturation of HIV virion 0.441214 0.355
R-HSA-182971 EGFR downregulation 0.441214 0.355
R-HSA-6807070 PTEN Regulation 0.444118 0.353
R-HSA-1852241 Organelle biogenesis and maintenance 0.444430 0.352
R-HSA-69190 DNA strand elongation 0.449945 0.347
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.450701 0.346
R-HSA-112315 Transmission across Chemical Synapses 0.452687 0.344
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.458540 0.339
R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.458540 0.339
R-HSA-1839124 FGFR1 mutant receptor activation 0.458540 0.339
R-HSA-5675482 Regulation of necroptotic cell death 0.458540 0.339
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.458540 0.339
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.461113 0.336
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.461490 0.336
R-HSA-376176 Signaling by ROBO receptors 0.461490 0.336
R-HSA-390522 Striated Muscle Contraction 0.467001 0.331
R-HSA-163359 Glucagon signaling in metabolic regulation 0.467001 0.331
R-HSA-114508 Effects of PIP2 hydrolysis 0.467001 0.331
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.467001 0.331
R-HSA-5223345 Miscellaneous transport and binding events 0.467001 0.331
R-HSA-381070 IRE1alpha activates chaperones 0.471409 0.327
R-HSA-9711123 Cellular response to chemical stress 0.473506 0.325
R-HSA-190861 Gap junction assembly 0.475331 0.323
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.475331 0.323
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.475331 0.323
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.475331 0.323
R-HSA-2142845 Hyaluronan metabolism 0.475331 0.323
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.475331 0.323
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.476441 0.322
R-HSA-2682334 EPH-Ephrin signaling 0.476513 0.322
R-HSA-169911 Regulation of Apoptosis 0.483531 0.316
R-HSA-5654696 Downstream signaling of activated FGFR2 0.483531 0.316
R-HSA-5654687 Downstream signaling of activated FGFR1 0.483531 0.316
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.483531 0.316
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 0.483531 0.316
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.483531 0.316
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.486631 0.313
R-HSA-74158 RNA Polymerase III Transcription 0.491603 0.308
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.491603 0.308
R-HSA-9682385 FLT3 signaling in disease 0.491603 0.308
R-HSA-8853659 RET signaling 0.491603 0.308
R-HSA-114604 GPVI-mediated activation cascade 0.491603 0.308
R-HSA-397014 Muscle contraction 0.495303 0.305
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.499549 0.301
R-HSA-549127 SLC-mediated transport of organic cations 0.499549 0.301
R-HSA-109582 Hemostasis 0.499553 0.301
R-HSA-112316 Neuronal System 0.503487 0.298
R-HSA-6785470 tRNA processing in the mitochondrion 0.507372 0.295
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.507372 0.295
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.507372 0.295
R-HSA-190236 Signaling by FGFR 0.511386 0.291
R-HSA-422356 Regulation of insulin secretion 0.511386 0.291
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.515073 0.288
R-HSA-9614085 FOXO-mediated transcription 0.516243 0.287
R-HSA-8982491 Glycogen metabolism 0.522654 0.282
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.522654 0.282
R-HSA-8868766 rRNA processing in the mitochondrion 0.522654 0.282
R-HSA-1251985 Nuclear signaling by ERBB4 0.522654 0.282
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.530117 0.276
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.530117 0.276
R-HSA-3214841 PKMTs methylate histone lysines 0.530117 0.276
R-HSA-9694548 Maturation of spike protein 0.530117 0.276
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.530117 0.276
R-HSA-2559580 Oxidative Stress Induced Senescence 0.530620 0.275
R-HSA-5633007 Regulation of TP53 Activity 0.530797 0.275
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.537464 0.270
R-HSA-5674135 MAP2K and MAPK activation 0.537464 0.270
R-HSA-9656223 Signaling by RAF1 mutants 0.537464 0.270
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.537464 0.270
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.537464 0.270
R-HSA-6811438 Intra-Golgi traffic 0.537464 0.270
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.544696 0.264
R-HSA-165159 MTOR signalling 0.544696 0.264
R-HSA-110329 Cleavage of the damaged pyrimidine 0.544696 0.264
R-HSA-73928 Depyrimidination 0.544696 0.264
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.544696 0.264
R-HSA-5619507 Activation of HOX genes during differentiation 0.544705 0.264
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.544705 0.264
R-HSA-73894 DNA Repair 0.551413 0.259
R-HSA-9710421 Defective pyroptosis 0.551816 0.258
R-HSA-5654743 Signaling by FGFR4 0.551816 0.258
R-HSA-8854214 TBC/RABGAPs 0.551816 0.258
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.551816 0.258
R-HSA-9637690 Response of Mtb to phagocytosis 0.551816 0.258
R-HSA-69239 Synthesis of DNA 0.558494 0.253
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.558494 0.253
R-HSA-9700206 Signaling by ALK in cancer 0.558494 0.253
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.558825 0.253
R-HSA-2172127 DAP12 interactions 0.558825 0.253
R-HSA-3214858 RMTs methylate histone arginines 0.558825 0.253
R-HSA-375280 Amine ligand-binding receptors 0.558825 0.253
R-HSA-5683826 Surfactant metabolism 0.558825 0.253
R-HSA-774815 Nucleosome assembly 0.565724 0.247
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.565724 0.247
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.565724 0.247
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.565724 0.247
R-HSA-5654741 Signaling by FGFR3 0.565724 0.247
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.565724 0.247
R-HSA-6783310 Fanconi Anemia Pathway 0.565724 0.247
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.565724 0.247
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.565724 0.247
R-HSA-9649948 Signaling downstream of RAS mutants 0.572516 0.242
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.572516 0.242
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.572516 0.242
R-HSA-6802949 Signaling by RAS mutants 0.572516 0.242
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.572516 0.242
R-HSA-9861718 Regulation of pyruvate metabolism 0.572516 0.242
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.572516 0.242
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.572516 0.242
R-HSA-75153 Apoptotic execution phase 0.572516 0.242
R-HSA-9634597 GPER1 signaling 0.585785 0.232
R-HSA-5620924 Intraflagellar transport 0.585785 0.232
R-HSA-70263 Gluconeogenesis 0.585785 0.232
R-HSA-9031628 NGF-stimulated transcription 0.585785 0.232
R-HSA-389356 Co-stimulation by CD28 0.585785 0.232
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.598064 0.223
R-HSA-109704 PI3K Cascade 0.598643 0.223
R-HSA-5655253 Signaling by FGFR2 in disease 0.598643 0.223
R-HSA-1169091 Activation of NF-kappaB in B cells 0.604922 0.218
R-HSA-9864848 Complex IV assembly 0.604922 0.218
R-HSA-9675108 Nervous system development 0.608451 0.216
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.610968 0.214
R-HSA-913531 Interferon Signaling 0.610968 0.214
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.611104 0.214
R-HSA-73772 RNA Polymerase I Promoter Escape 0.611104 0.214
R-HSA-68949 Orc1 removal from chromatin 0.611104 0.214
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.611104 0.214
R-HSA-201681 TCF dependent signaling in response to WNT 0.616141 0.210
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.617189 0.210
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.617189 0.210
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.617189 0.210
R-HSA-72649 Translation initiation complex formation 0.623179 0.205
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 0.623179 0.205
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.623179 0.205
R-HSA-69275 G2/M Transition 0.626046 0.203
R-HSA-73886 Chromosome Maintenance 0.626964 0.203
R-HSA-212165 Epigenetic regulation of gene expression 0.627328 0.203
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.629076 0.201
R-HSA-3214815 HDACs deacetylate histones 0.629076 0.201
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.629076 0.201
R-HSA-418597 G alpha (z) signalling events 0.629076 0.201
R-HSA-453274 Mitotic G2-G2/M phases 0.632552 0.199
R-HSA-72702 Ribosomal scanning and start codon recognition 0.634880 0.197
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.634880 0.197
R-HSA-5654736 Signaling by FGFR1 0.634880 0.197
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.634921 0.197
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.634921 0.197
R-HSA-5617833 Cilium Assembly 0.638979 0.195
R-HSA-112399 IRS-mediated signalling 0.640595 0.193
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.646220 0.190
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.646220 0.190
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.646607 0.189
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.646607 0.189
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.646607 0.189
R-HSA-69206 G1/S Transition 0.646607 0.189
R-HSA-180786 Extension of Telomeres 0.651758 0.186
R-HSA-429914 Deadenylation-dependent mRNA decay 0.651758 0.186
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.657209 0.182
R-HSA-983189 Kinesins 0.657209 0.182
R-HSA-445717 Aquaporin-mediated transport 0.662575 0.179
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.662575 0.179
R-HSA-450294 MAP kinase activation 0.662575 0.179
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.665425 0.177
R-HSA-422475 Axon guidance 0.667447 0.176
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.667858 0.175
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.667858 0.175
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.669933 0.174
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.673058 0.172
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.673058 0.172
R-HSA-69615 G1/S DNA Damage Checkpoints 0.673058 0.172
R-HSA-8856688 Golgi-to-ER retrograde transport 0.676324 0.170
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.678177 0.169
R-HSA-74751 Insulin receptor signalling cascade 0.678177 0.169
R-HSA-5683057 MAPK family signaling cascades 0.685351 0.164
R-HSA-9018519 Estrogen-dependent gene expression 0.693849 0.159
R-HSA-163685 Integration of energy metabolism 0.693849 0.159
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.697868 0.156
R-HSA-5218859 Regulated Necrosis 0.697868 0.156
R-HSA-381119 Unfolded Protein Response (UPR) 0.703984 0.152
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.707258 0.150
R-HSA-69202 Cyclin E associated events during G1/S transition 0.707258 0.150
R-HSA-448424 Interleukin-17 signaling 0.707258 0.150
R-HSA-1632852 Macroautophagy 0.710585 0.148
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.711844 0.148
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.711844 0.148
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.716358 0.145
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.716358 0.145
R-HSA-5673001 RAF/MAP kinase cascade 0.716668 0.145
R-HSA-69052 Switching of origins to a post-replicative state 0.720801 0.142
R-HSA-5663084 Diseases of carbohydrate metabolism 0.720801 0.142
R-HSA-418990 Adherens junctions interactions 0.723309 0.141
R-HSA-9824446 Viral Infection Pathways 0.725026 0.140
R-HSA-9013694 Signaling by NOTCH4 0.725176 0.140
R-HSA-1236394 Signaling by ERBB4 0.725176 0.140
R-HSA-5684996 MAPK1/MAPK3 signaling 0.732767 0.135
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.733720 0.134
R-HSA-5689603 UCH proteinases 0.733720 0.134
R-HSA-69242 S Phase 0.735772 0.133
R-HSA-9694635 Translation of Structural Proteins 0.737893 0.132
R-HSA-73864 RNA Polymerase I Transcription 0.742001 0.130
R-HSA-383280 Nuclear Receptor transcription pathway 0.742001 0.130
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.744727 0.128
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.746044 0.127
R-HSA-446652 Interleukin-1 family signaling 0.747653 0.126
R-HSA-69306 DNA Replication 0.750551 0.125
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.753421 0.123
R-HSA-72312 rRNA processing 0.758174 0.120
R-HSA-9612973 Autophagy 0.759074 0.120
R-HSA-1643685 Disease 0.759838 0.119
R-HSA-6798695 Neutrophil degranulation 0.763777 0.117
R-HSA-5687128 MAPK6/MAPK4 signaling 0.769013 0.114
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.776199 0.110
R-HSA-70268 Pyruvate metabolism 0.779709 0.108
R-HSA-9645723 Diseases of programmed cell death 0.783163 0.106
R-HSA-112310 Neurotransmitter release cycle 0.789911 0.102
R-HSA-73884 Base Excision Repair 0.789911 0.102
R-HSA-202424 Downstream TCR signaling 0.789911 0.102
R-HSA-1280218 Adaptive Immune System 0.792114 0.101
R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.793206 0.101
R-HSA-8986944 Transcriptional Regulation by MECP2 0.793206 0.101
R-HSA-74752 Signaling by Insulin receptor 0.799643 0.097
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.799643 0.097
R-HSA-418555 G alpha (s) signalling events 0.800398 0.097
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.802760 0.095
R-HSA-418594 G alpha (i) signalling events 0.804102 0.095
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.805097 0.094
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.805097 0.094
R-HSA-388841 Regulation of T cell activation by CD28 family 0.809637 0.092
R-HSA-72689 Formation of a pool of free 40S subunits 0.811924 0.090
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.814875 0.089
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.814875 0.089
R-HSA-6807878 COPI-mediated anterograde transport 0.814875 0.089
R-HSA-157579 Telomere Maintenance 0.817780 0.087
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.817780 0.087
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.820640 0.086
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.820640 0.086
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.820640 0.086
R-HSA-2559583 Cellular Senescence 0.820783 0.086
R-HSA-9842860 Regulation of endogenous retroelements 0.831639 0.080
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.837321 0.077
R-HSA-9833110 RSV-host interactions 0.839444 0.076
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.841965 0.075
R-HSA-597592 Post-translational protein modification 0.843334 0.074
R-HSA-9692914 SARS-CoV-1-host interactions 0.844447 0.073
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.845063 0.073
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.849294 0.071
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.849294 0.071
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.849294 0.071
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.849294 0.071
R-HSA-2672351 Stimuli-sensing channels 0.849294 0.071
R-HSA-69002 DNA Replication Pre-Initiation 0.851661 0.070
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.851661 0.070
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.852471 0.069
R-HSA-9824443 Parasitic Infection Pathways 0.853133 0.069
R-HSA-9658195 Leishmania infection 0.853133 0.069
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.853990 0.069
R-HSA-166166 MyD88-independent TLR4 cascade 0.853990 0.069
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.858541 0.066
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.858541 0.066
R-HSA-389948 Co-inhibition by PD-1 0.859555 0.066
R-HSA-1912422 Pre-NOTCH Expression and Processing 0.860764 0.065
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.860764 0.065
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.867224 0.062
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.869310 0.061
R-HSA-5357801 Programmed Cell Death 0.869602 0.061
R-HSA-72737 Cap-dependent Translation Initiation 0.871364 0.060
R-HSA-72613 Eukaryotic Translation Initiation 0.871364 0.060
R-HSA-373760 L1CAM interactions 0.871364 0.060
R-HSA-9007101 Rab regulation of trafficking 0.873385 0.059
R-HSA-1483257 Phospholipid metabolism 0.873509 0.059
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.877334 0.057
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.877334 0.057
R-HSA-195721 Signaling by WNT 0.877537 0.057
R-HSA-388396 GPCR downstream signalling 0.880778 0.055
R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.881160 0.055
R-HSA-9730414 MITF-M-regulated melanocyte development 0.881974 0.055
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.883028 0.054
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.883028 0.054
R-HSA-2132295 MHC class II antigen presentation 0.884867 0.053
R-HSA-168256 Immune System 0.891803 0.050
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.891939 0.050
R-HSA-8951664 Neddylation 0.893256 0.049
R-HSA-1266738 Developmental Biology 0.893849 0.049
R-HSA-9843745 Adipogenesis 0.901744 0.045
R-HSA-199991 Membrane Trafficking 0.903746 0.044
R-HSA-5663205 Infectious disease 0.907823 0.042
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.912068 0.040
R-HSA-8939211 ESR-mediated signaling 0.912883 0.040
R-HSA-9664407 Parasite infection 0.916155 0.038
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.916155 0.038
R-HSA-9664417 Leishmania phagocytosis 0.916155 0.038
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.917475 0.037
R-HSA-8856828 Clathrin-mediated endocytosis 0.921312 0.036
R-HSA-2871837 FCERI mediated NF-kB activation 0.922551 0.035
R-HSA-199977 ER to Golgi Anterograde Transport 0.926152 0.033
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.927315 0.033
R-HSA-9758941 Gastrulation 0.928460 0.032
R-HSA-9856651 MITF-M-dependent gene expression 0.929587 0.032
R-HSA-9679191 Potential therapeutics for SARS 0.929587 0.032
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.931788 0.031
R-HSA-1989781 PPARA activates gene expression 0.934961 0.029
R-HSA-372790 Signaling by GPCR 0.936681 0.028
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.936995 0.028
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.937988 0.028
R-HSA-416476 G alpha (q) signalling events 0.938546 0.028
R-HSA-9006936 Signaling by TGFB family members 0.939927 0.027
R-HSA-109581 Apoptosis 0.941806 0.026
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.949562 0.022
R-HSA-5621481 C-type lectin receptors (CLRs) 0.950358 0.022
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.951911 0.021
R-HSA-9664433 Leishmania parasite growth and survival 0.951911 0.021
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.952670 0.021
R-HSA-9678108 SARS-CoV-1 Infection 0.953417 0.021
R-HSA-611105 Respiratory electron transport 0.955587 0.020
R-HSA-9824439 Bacterial Infection Pathways 0.957446 0.019
R-HSA-375276 Peptide ligand-binding receptors 0.960895 0.017
R-HSA-983712 Ion channel transport 0.962718 0.017
R-HSA-168898 Toll-like Receptor Cascades 0.963886 0.016
R-HSA-1630316 Glycosaminoglycan metabolism 0.965018 0.015
R-HSA-948021 Transport to the Golgi and subsequent modification 0.969689 0.013
R-HSA-5653656 Vesicle-mediated transport 0.977152 0.010
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.978053 0.010
R-HSA-168249 Innate Immune System 0.981788 0.008
R-HSA-202733 Cell surface interactions at the vascular wall 0.982929 0.007
R-HSA-9006931 Signaling by Nuclear Receptors 0.983773 0.007
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.989595 0.005
R-HSA-8957322 Metabolism of steroids 0.995760 0.002
R-HSA-392499 Metabolism of proteins 0.996748 0.001
R-HSA-425407 SLC-mediated transmembrane transport 0.998711 0.001
R-HSA-446203 Asparagine N-linked glycosylation 0.999139 0.000
R-HSA-5668914 Diseases of metabolism 0.999206 0.000
R-HSA-72766 Translation 0.999231 0.000
R-HSA-500792 GPCR ligand binding 0.999374 0.000
R-HSA-382551 Transport of small molecules 0.999918 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-556833 Metabolism of lipids 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
CLK3CLK3 0.808 0.251 1 0.893
KISKIS 0.796 0.266 1 0.902
HIPK4HIPK4 0.794 0.263 1 0.872
HIPK2HIPK2 0.794 0.305 1 0.864
COTCOT 0.791 0.167 2 0.861
DYRK2DYRK2 0.789 0.291 1 0.905
SRPK1SRPK1 0.789 0.182 -3 0.777
CDK1CDK1 0.788 0.286 1 0.878
CLK2CLK2 0.788 0.201 -3 0.777
CDK18CDK18 0.787 0.284 1 0.862
JNK2JNK2 0.786 0.337 1 0.872
MOSMOS 0.783 0.174 1 0.804
CDK19CDK19 0.783 0.286 1 0.878
CDK7CDK7 0.783 0.278 1 0.900
NLKNLK 0.782 0.231 1 0.908
CDK8CDK8 0.782 0.271 1 0.895
CDC7CDC7 0.781 0.063 1 0.771
HIPK1HIPK1 0.781 0.281 1 0.906
PIM3PIM3 0.780 0.106 -3 0.853
MTORMTOR 0.780 0.094 1 0.776
JNK3JNK3 0.780 0.312 1 0.892
DYRK4DYRK4 0.780 0.274 1 0.882
P38BP38B 0.780 0.302 1 0.876
NDR2NDR2 0.779 0.085 -3 0.849
ICKICK 0.779 0.217 -3 0.850
CDK3CDK3 0.778 0.257 1 0.847
CDK5CDK5 0.778 0.258 1 0.903
GSK3AGSK3A 0.777 0.057 4 0.074
P38GP38G 0.777 0.292 1 0.831
CDK17CDK17 0.776 0.272 1 0.832
GRK1GRK1 0.776 0.069 -2 0.789
CDKL5CDKL5 0.775 0.135 -3 0.811
SKMLCKSKMLCK 0.775 0.131 -2 0.911
RSK2RSK2 0.774 0.108 -3 0.791
SRPK2SRPK2 0.774 0.131 -3 0.703
P38AP38A 0.774 0.279 1 0.898
CDKL1CDKL1 0.774 0.110 -3 0.816
ERK5ERK5 0.773 0.147 1 0.856
ERK1ERK1 0.773 0.270 1 0.870
AURCAURC 0.772 0.139 -2 0.750
CLK4CLK4 0.771 0.170 -3 0.782
CDK13CDK13 0.771 0.243 1 0.886
CDK14CDK14 0.771 0.276 1 0.881
CDK16CDK16 0.770 0.265 1 0.842
MAKMAK 0.770 0.285 -2 0.864
CDK10CDK10 0.770 0.261 1 0.875
ATRATR 0.770 0.063 1 0.767
P38DP38D 0.770 0.284 1 0.849
DYRK1ADYRK1A 0.770 0.232 1 0.906
PRKD1PRKD1 0.769 0.099 -3 0.839
PRPKPRPK 0.769 -0.022 -1 0.833
PIM1PIM1 0.768 0.088 -3 0.806
CLK1CLK1 0.768 0.173 -3 0.761
CDK12CDK12 0.768 0.249 1 0.872
DYRK1BDYRK1B 0.767 0.248 1 0.888
CHAK2CHAK2 0.767 0.078 -1 0.817
CAMK1BCAMK1B 0.766 0.044 -3 0.858
NDR1NDR1 0.766 0.063 -3 0.839
P90RSKP90RSK 0.766 0.086 -3 0.795
IKKBIKKB 0.766 -0.004 -2 0.715
PKACBPKACB 0.766 0.132 -2 0.760
SRPK3SRPK3 0.766 0.107 -3 0.744
HIPK3HIPK3 0.765 0.253 1 0.889
GSK3BGSK3B 0.765 -0.010 4 0.077
RAF1RAF1 0.765 -0.042 1 0.736
RSK4RSK4 0.765 0.111 -3 0.771
PRKD2PRKD2 0.765 0.086 -3 0.796
JNK1JNK1 0.764 0.270 1 0.867
PKACGPKACG 0.763 0.076 -2 0.812
DYRK3DYRK3 0.763 0.218 1 0.895
RSK3RSK3 0.763 0.074 -3 0.782
CDK9CDK9 0.762 0.231 1 0.888
GRK7GRK7 0.762 0.072 1 0.703
CAMLCKCAMLCK 0.762 0.079 -2 0.887
DAPK2DAPK2 0.762 0.073 -3 0.861
PRKXPRKX 0.761 0.105 -3 0.710
TBK1TBK1 0.761 -0.043 1 0.645
PKN3PKN3 0.761 0.044 -3 0.834
CAMK2GCAMK2G 0.760 -0.066 2 0.801
CAMK2ACAMK2A 0.759 0.049 2 0.796
IKKAIKKA 0.759 0.005 -2 0.702
P70S6KBP70S6KB 0.759 0.057 -3 0.803
MAPKAPK2MAPKAPK2 0.758 0.074 -3 0.759
PKCDPKCD 0.758 0.088 2 0.750
NIKNIK 0.758 0.052 -3 0.868
BMPR2BMPR2 0.758 -0.060 -2 0.859
LATS2LATS2 0.758 0.030 -5 0.719
MST4MST4 0.758 -0.008 2 0.826
GRK5GRK5 0.758 -0.015 -3 0.833
IKKEIKKE 0.758 -0.051 1 0.642
NEK6NEK6 0.758 0.022 -2 0.836
ERK2ERK2 0.758 0.225 1 0.882
PKN2PKN2 0.758 0.034 -3 0.837
PDHK4PDHK4 0.758 -0.127 1 0.776
CDK2CDK2 0.757 0.161 1 0.896
WNK1WNK1 0.757 -0.009 -2 0.899
CAMK2DCAMK2D 0.757 0.053 -3 0.839
DSTYKDSTYK 0.757 -0.010 2 0.876
RIPK3RIPK3 0.757 -0.004 3 0.651
MSK1MSK1 0.757 0.084 -3 0.764
NUAK2NUAK2 0.757 -0.015 -3 0.852
AKT2AKT2 0.756 0.114 -3 0.715
LATS1LATS1 0.756 0.058 -3 0.854
CAMK2BCAMK2B 0.756 0.020 2 0.781
GCN2GCN2 0.756 -0.113 2 0.774
BMPR1BBMPR1B 0.756 0.057 1 0.713
AMPKA1AMPKA1 0.755 -0.012 -3 0.857
MARK4MARK4 0.755 -0.054 4 0.168
ULK2ULK2 0.754 -0.061 2 0.757
PRP4PRP4 0.754 0.169 -3 0.776
TGFBR2TGFBR2 0.754 -0.004 -2 0.780
PAK1PAK1 0.754 0.070 -2 0.850
PKG2PKG2 0.753 0.107 -2 0.760
GRK6GRK6 0.753 -0.046 1 0.744
MLK2MLK2 0.753 0.091 2 0.796
PKCAPKCA 0.752 0.078 2 0.688
MAPKAPK3MAPKAPK3 0.751 0.043 -3 0.791
AMPKA2AMPKA2 0.751 -0.000 -3 0.830
MNK2MNK2 0.751 0.063 -2 0.844
MLK1MLK1 0.751 -0.065 2 0.784
MLK3MLK3 0.750 0.050 2 0.710
PAK6PAK6 0.750 0.126 -2 0.766
MASTLMASTL 0.750 -0.037 -2 0.806
PKCBPKCB 0.750 0.043 2 0.702
MSK2MSK2 0.750 0.033 -3 0.762
AURBAURB 0.750 0.080 -2 0.743
PASKPASK 0.750 0.099 -3 0.866
MOKMOK 0.749 0.226 1 0.873
PKCGPKCG 0.749 0.046 2 0.703
PDHK1PDHK1 0.749 -0.132 1 0.754
MNK1MNK1 0.749 0.066 -2 0.849
FAM20CFAM20C 0.748 0.005 2 0.639
PAK3PAK3 0.748 0.058 -2 0.836
NEK7NEK7 0.748 -0.091 -3 0.824
TSSK1TSSK1 0.748 -0.013 -3 0.876
DLKDLK 0.747 -0.075 1 0.734
CDK6CDK6 0.747 0.233 1 0.870
SGK3SGK3 0.747 0.087 -3 0.774
QSKQSK 0.747 -0.023 4 0.175
TGFBR1TGFBR1 0.746 0.015 -2 0.773
GRK4GRK4 0.746 -0.058 -2 0.812
BCKDKBCKDK 0.746 -0.090 -1 0.736
TSSK2TSSK2 0.745 -0.028 -5 0.787
HUNKHUNK 0.745 -0.135 2 0.810
MYLK4MYLK4 0.745 0.050 -2 0.834
ALK4ALK4 0.745 0.014 -2 0.804
PRKD3PRKD3 0.745 0.048 -3 0.758
AURAAURA 0.744 0.052 -2 0.716
CDK4CDK4 0.744 0.233 1 0.866
PIM2PIM2 0.744 0.070 -3 0.762
ANKRD3ANKRD3 0.744 -0.041 1 0.755
PKACAPKACA 0.743 0.095 -2 0.716
IRE1IRE1 0.743 -0.064 1 0.685
MPSK1MPSK1 0.743 0.119 1 0.713
PKCZPKCZ 0.743 0.021 2 0.745
ATMATM 0.743 -0.041 1 0.713
TLK2TLK2 0.743 0.050 1 0.701
AKT3AKT3 0.743 0.159 -3 0.664
ULK1ULK1 0.742 -0.088 -3 0.795
VRK2VRK2 0.742 0.004 1 0.810
NIM1NIM1 0.742 -0.059 3 0.684
DNAPKDNAPK 0.741 0.002 1 0.662
RIPK1RIPK1 0.741 -0.083 1 0.702
CAMK4CAMK4 0.741 -0.015 -3 0.820
SMG1SMG1 0.741 -0.005 1 0.723
PAK2PAK2 0.740 0.038 -2 0.830
WNK3WNK3 0.740 -0.188 1 0.711
MARK3MARK3 0.740 -0.065 4 0.135
CK1ECK1E 0.740 0.018 -3 0.574
PHKG1PHKG1 0.739 -0.002 -3 0.832
ACVR2BACVR2B 0.739 0.005 -2 0.770
MEK1MEK1 0.739 -0.062 2 0.836
AKT1AKT1 0.739 0.095 -3 0.732
MLK4MLK4 0.739 0.003 2 0.689
TTBK2TTBK2 0.739 -0.073 2 0.696
SIKSIK 0.738 -0.032 -3 0.769
PKRPKR 0.738 -0.069 1 0.739
NEK9NEK9 0.738 -0.104 2 0.805
PLK1PLK1 0.737 -0.050 -2 0.776
DCAMKL1DCAMKL1 0.737 0.029 -3 0.802
PKCHPKCH 0.737 -0.005 2 0.682
ACVR2AACVR2A 0.737 -0.005 -2 0.757
IRE2IRE2 0.736 -0.034 2 0.704
MARK2MARK2 0.736 -0.093 4 0.124
MELKMELK 0.736 -0.006 -3 0.810
MST3MST3 0.736 0.010 2 0.821
YSK4YSK4 0.736 -0.035 1 0.673
BRSK1BRSK1 0.736 -0.048 -3 0.798
NUAK1NUAK1 0.735 -0.042 -3 0.796
QIKQIK 0.735 -0.103 -3 0.826
CK1DCK1D 0.733 0.034 -3 0.524
ALK2ALK2 0.733 -0.036 -2 0.782
TAO3TAO3 0.733 -0.004 1 0.710
BRSK2BRSK2 0.732 -0.072 -3 0.812
CHAK1CHAK1 0.732 -0.108 2 0.757
DRAK1DRAK1 0.732 -0.051 1 0.671
DAPK3DAPK3 0.732 0.049 -3 0.813
BMPR1ABMPR1A 0.732 -0.002 1 0.696
GRK2GRK2 0.731 -0.050 -2 0.701
ERK7ERK7 0.731 0.075 2 0.499
PLK4PLK4 0.730 -0.010 2 0.614
PAK4PAK4 0.730 0.104 -2 0.724
CHK1CHK1 0.730 0.015 -3 0.826
SGK1SGK1 0.730 0.082 -3 0.642
CK1A2CK1A2 0.730 0.020 -3 0.525
GAKGAK 0.729 0.019 1 0.767
PLK3PLK3 0.729 -0.081 2 0.775
CAMK1GCAMK1G 0.729 -0.028 -3 0.773
PKCTPKCT 0.729 0.018 2 0.689
SSTKSSTK 0.729 -0.037 4 0.168
PAK5PAK5 0.729 0.080 -2 0.714
NEK2NEK2 0.728 -0.068 2 0.782
BRAFBRAF 0.728 0.003 -4 0.753
DAPK1DAPK1 0.728 0.047 -3 0.797
SMMLCKSMMLCK 0.728 0.016 -3 0.818
MEK5MEK5 0.727 -0.094 2 0.807
PKCEPKCE 0.727 0.030 2 0.686
PINK1PINK1 0.727 -0.019 1 0.812
NEK5NEK5 0.726 -0.012 1 0.721
LKB1LKB1 0.726 0.102 -3 0.819
MARK1MARK1 0.726 -0.102 4 0.139
MEKK2MEKK2 0.725 -0.031 2 0.778
ZAKZAK 0.725 -0.068 1 0.682
CK1G1CK1G1 0.725 -0.009 -3 0.553
MEKK3MEKK3 0.724 -0.104 1 0.707
P70S6KP70S6K 0.724 0.015 -3 0.718
DCAMKL2DCAMKL2 0.724 -0.005 -3 0.817
GCKGCK 0.723 0.013 1 0.702
MAPKAPK5MAPKAPK5 0.723 -0.044 -3 0.731
ROCK2ROCK2 0.723 0.086 -3 0.797
CK2A2CK2A2 0.722 -0.029 1 0.656
TLK1TLK1 0.722 -0.049 -2 0.805
NEK11NEK11 0.722 -0.061 1 0.700
PDK1PDK1 0.722 0.029 1 0.713
IRAK4IRAK4 0.722 -0.069 1 0.685
MEKK1MEKK1 0.722 -0.116 1 0.716
SNRKSNRK 0.722 -0.103 2 0.662
WNK4WNK4 0.722 -0.105 -2 0.886
PKCIPKCI 0.721 -0.003 2 0.706
PERKPERK 0.721 -0.086 -2 0.810
CAMK1DCAMK1D 0.721 0.015 -3 0.702
MRCKBMRCKB 0.721 0.077 -3 0.748
GRK3GRK3 0.720 -0.046 -2 0.661
MRCKAMRCKA 0.720 0.056 -3 0.760
SBKSBK 0.719 0.091 -3 0.608
BUB1BUB1 0.719 0.051 -5 0.763
TNIKTNIK 0.718 0.028 3 0.780
DMPK1DMPK1 0.717 0.092 -3 0.776
CK2A1CK2A1 0.717 -0.035 1 0.635
HPK1HPK1 0.717 -0.002 1 0.688
MAP3K15MAP3K15 0.716 -0.024 1 0.673
TAO2TAO2 0.716 -0.077 2 0.815
CAMKK2CAMKK2 0.716 0.001 -2 0.729
MEKK6MEKK6 0.716 -0.039 1 0.700
NEK8NEK8 0.716 -0.058 2 0.785
PBKPBK 0.715 0.064 1 0.704
PLK2PLK2 0.715 -0.031 -3 0.766
HRIHRI 0.714 -0.167 -2 0.825
KHS1KHS1 0.714 0.025 1 0.682
PHKG2PHKG2 0.714 -0.087 -3 0.798
PDHK3_TYRPDHK3_TYR 0.713 0.175 4 0.211
HGKHGK 0.713 -0.015 3 0.778
KHS2KHS2 0.713 0.023 1 0.695
PKN1PKN1 0.712 0.020 -3 0.737
CAMKK1CAMKK1 0.712 -0.084 -2 0.720
MST2MST2 0.711 -0.054 1 0.710
MINKMINK 0.711 -0.057 1 0.682
EEF2KEEF2K 0.711 -0.054 3 0.747
LOKLOK 0.710 0.012 -2 0.774
NEK4NEK4 0.710 -0.047 1 0.681
TAK1TAK1 0.710 -0.027 1 0.709
LRRK2LRRK2 0.710 -0.085 2 0.818
CAMK1ACAMK1A 0.710 0.027 -3 0.680
CHK2CHK2 0.709 0.011 -3 0.663
CRIKCRIK 0.709 0.071 -3 0.735
YANK3YANK3 0.709 -0.017 2 0.413
SLKSLK 0.708 -0.008 -2 0.716
TTBK1TTBK1 0.707 -0.102 2 0.615
PDHK4_TYRPDHK4_TYR 0.707 0.099 2 0.876
PKG1PKG1 0.705 0.050 -2 0.680
NEK1NEK1 0.705 -0.046 1 0.688
VRK1VRK1 0.705 -0.127 2 0.815
STK33STK33 0.705 -0.060 2 0.607
MAP2K4_TYRMAP2K4_TYR 0.705 0.157 -1 0.837
MAP2K6_TYRMAP2K6_TYR 0.704 0.095 -1 0.845
ROCK1ROCK1 0.704 0.043 -3 0.762
TESK1_TYRTESK1_TYR 0.704 0.128 3 0.794
LIMK2_TYRLIMK2_TYR 0.703 0.164 -3 0.875
HASPINHASPIN 0.703 -0.001 -1 0.682
MST1MST1 0.703 -0.069 1 0.687
IRAK1IRAK1 0.701 -0.183 -1 0.700
OSR1OSR1 0.701 -0.006 2 0.777
YSK1YSK1 0.700 -0.051 2 0.775
PDHK1_TYRPDHK1_TYR 0.700 0.067 -1 0.848
CK1ACK1A 0.700 -0.003 -3 0.436
BMPR2_TYRBMPR2_TYR 0.700 0.051 -1 0.857
PKMYT1_TYRPKMYT1_TYR 0.698 0.014 3 0.758
MEK2MEK2 0.697 -0.131 2 0.796
TTKTTK 0.696 -0.055 -2 0.805
MAP2K7_TYRMAP2K7_TYR 0.696 -0.019 2 0.847
EPHA6EPHA6 0.694 0.058 -1 0.813
TXKTXK 0.692 0.108 1 0.748
MYO3BMYO3B 0.692 -0.031 2 0.793
ALPHAK3ALPHAK3 0.690 -0.039 -1 0.745
BIKEBIKE 0.690 -0.004 1 0.672
EPHB4EPHB4 0.689 0.033 -1 0.772
ASK1ASK1 0.689 -0.065 1 0.664
NEK3NEK3 0.689 -0.064 1 0.669
PINK1_TYRPINK1_TYR 0.688 -0.128 1 0.758
RIPK2RIPK2 0.688 -0.187 1 0.641
RETRET 0.687 -0.021 1 0.717
MYO3AMYO3A 0.686 -0.063 1 0.680
LIMK1_TYRLIMK1_TYR 0.685 -0.082 2 0.826
LCKLCK 0.683 0.018 -1 0.803
TNK2TNK2 0.683 0.047 3 0.657
MST1RMST1R 0.683 -0.064 3 0.702
FGRFGR 0.683 -0.014 1 0.747
TAO1TAO1 0.683 -0.101 1 0.636
DDR1DDR1 0.683 -0.110 4 0.168
ABL2ABL2 0.682 -0.027 -1 0.755
TYRO3TYRO3 0.682 -0.047 3 0.688
ROS1ROS1 0.681 -0.068 3 0.661
EPHA4EPHA4 0.681 -0.000 2 0.784
YES1YES1 0.681 -0.060 -1 0.799
CSF1RCSF1R 0.681 -0.059 3 0.674
AAK1AAK1 0.680 0.031 1 0.593
BLKBLK 0.679 -0.005 -1 0.796
JAK3JAK3 0.679 -0.055 1 0.702
JAK2JAK2 0.678 -0.075 1 0.717
ITKITK 0.678 -0.021 -1 0.754
FERFER 0.678 -0.094 1 0.775
METMET 0.677 -0.020 3 0.677
FGFR2FGFR2 0.677 -0.032 3 0.707
ABL1ABL1 0.677 -0.059 -1 0.745
KDRKDR 0.677 -0.006 3 0.643
SRMSSRMS 0.676 -0.028 1 0.752
TNK1TNK1 0.675 -0.006 3 0.675
HCKHCK 0.675 -0.064 -1 0.791
INSRRINSRR 0.675 -0.087 3 0.643
YANK2YANK2 0.675 -0.038 2 0.425
TYK2TYK2 0.675 -0.191 1 0.711
FYNFYN 0.675 0.004 -1 0.797
BMXBMX 0.674 -0.010 -1 0.695
EPHB1EPHB1 0.674 -0.029 1 0.749
EPHB3EPHB3 0.673 0.005 -1 0.751
TEKTEK 0.673 -0.003 3 0.631
KITKIT 0.673 -0.078 3 0.681
EPHB2EPHB2 0.672 -0.035 -1 0.746
TNNI3K_TYRTNNI3K_TYR 0.671 -0.007 1 0.732
MERTKMERTK 0.670 -0.043 3 0.664
STLK3STLK3 0.669 -0.113 1 0.651
CK1G3CK1G3 0.669 -0.024 -3 0.390
NEK10_TYRNEK10_TYR 0.669 -0.059 1 0.598
EPHA7EPHA7 0.669 -0.008 2 0.774
JAK1JAK1 0.669 -0.062 1 0.661
FGFR1FGFR1 0.669 -0.044 3 0.656
DDR2DDR2 0.668 -0.063 3 0.636
FLT1FLT1 0.668 -0.015 -1 0.787
FGFR3FGFR3 0.667 -0.047 3 0.676
AXLAXL 0.667 -0.061 3 0.668
PTK2PTK2 0.666 0.021 -1 0.786
EPHA3EPHA3 0.665 -0.057 2 0.749
TECTEC 0.665 -0.080 -1 0.673
PDGFRBPDGFRB 0.664 -0.150 3 0.688
CK1G2CK1G2 0.664 -0.022 -3 0.477
EPHA1EPHA1 0.663 -0.052 3 0.657
PTK6PTK6 0.663 -0.085 -1 0.684
FLT3FLT3 0.663 -0.176 3 0.681
LYNLYN 0.662 -0.058 3 0.603
ERBB2ERBB2 0.662 -0.083 1 0.681
ALKALK 0.661 -0.110 3 0.600
WEE1_TYRWEE1_TYR 0.661 -0.101 -1 0.716
SYKSYK 0.661 0.003 -1 0.761
PTK2BPTK2B 0.660 -0.053 -1 0.710
FRKFRK 0.660 -0.083 -1 0.778
EPHA8EPHA8 0.659 -0.021 -1 0.756
LTKLTK 0.659 -0.103 3 0.627
SRCSRC 0.659 -0.056 -1 0.776
EPHA5EPHA5 0.659 -0.053 2 0.766
BTKBTK 0.659 -0.163 -1 0.711
MATKMATK 0.658 -0.059 -1 0.688
PDGFRAPDGFRA 0.658 -0.143 3 0.682
NTRK1NTRK1 0.657 -0.134 -1 0.761
NTRK3NTRK3 0.657 -0.037 -1 0.721
INSRINSR 0.656 -0.144 3 0.626
FGFR4FGFR4 0.655 -0.035 -1 0.715
FLT4FLT4 0.655 -0.106 3 0.644
EGFREGFR 0.655 -0.056 1 0.605
EPHA2EPHA2 0.652 -0.014 -1 0.728
ERBB4ERBB4 0.651 -0.019 1 0.631
ZAP70ZAP70 0.651 0.045 -1 0.710
CSKCSK 0.650 -0.092 2 0.778
NTRK2NTRK2 0.649 -0.164 3 0.627
IGF1RIGF1R 0.643 -0.120 3 0.569
MUSKMUSK 0.633 -0.122 1 0.591
FESFES 0.629 -0.115 -1 0.667