Motif 162 (n=196)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A5F9ZHR4 | AQP4 | S331 | psp | Aquaporin-4 | None |
| F5H423 | None | S62 | ochoa | ADP-ribosylation factor 3 | None |
| O00425 | IGF2BP3 | S481 | ochoa | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}. |
| O00499 | BIN1 | S276 | ochoa | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:24755653, ECO:0000269|PubMed:27179792, ECO:0000269|PubMed:28893863, ECO:0000269|PubMed:8782822}. |
| O00515 | LAD1 | S49 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O00716 | E2F3 | S359 | ochoa | Transcription factor E2F3 (E2F-3) | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}. |
| O14686 | KMT2D | S2296 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14920 | IKBKB | S177 | psp | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O14965 | AURKA | S89 | psp | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| O15015 | ZNF646 | S33 | ochoa | Zinc finger protein 646 | May be involved in transcriptional regulation. |
| O15117 | FYB1 | S573 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O43164 | PJA2 | S79 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43491 | EPB41L2 | S881 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43561 | LAT | S224 | ochoa | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481, ECO:0000269|PubMed:23514740, ECO:0000269|PubMed:25907557}. |
| O60264 | SMARCA5 | S158 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) | ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. |
| O60271 | SPAG9 | S194 | ochoa | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60293 | ZFC3H1 | S998 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60313 | OPA1 | S478 | ochoa | Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] | Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28628083, PubMed:28746876, PubMed:31922487, PubMed:32228866, PubMed:32567732, PubMed:33130824, PubMed:33237841, PubMed:37612504, PubMed:37612506). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:31922487, PubMed:32228866, PubMed:33237841, PubMed:37612504, PubMed:37612506). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:31922487, PubMed:37612504, PubMed:37612506). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (PubMed:20038677, PubMed:31922487). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Involved in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (PubMed:18158317, PubMed:20974897). {ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:17709429, ECO:0000269|PubMed:18158317, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:20185555, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:24616225, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:28746876, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:33237841, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, long form]: Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32567732, PubMed:33130824). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Dynamin-like GTPase OPA1, short form]: Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:31922487, PubMed:32228866, PubMed:32245890, PubMed:37612504, PubMed:37612506). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (PubMed:31922487, PubMed:32228866, PubMed:37612504, PubMed:37612506). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (PubMed:32228866, PubMed:37612504, PubMed:37612506). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (PubMed:37612504, PubMed:37612506). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:28628083, PubMed:37612504, PubMed:37612506). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (PubMed:20038677). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:32245890). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity). {ECO:0000250|UniProtKB:G0SGC7, ECO:0000250|UniProtKB:P58281, ECO:0000269|PubMed:20038677, ECO:0000269|PubMed:28628083, ECO:0000269|PubMed:31922487, ECO:0000269|PubMed:32228866, ECO:0000269|PubMed:32245890, ECO:0000269|PubMed:37612504, ECO:0000269|PubMed:37612506}.; FUNCTION: [Isoform 1]: Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion. {ECO:0000269|PubMed:17709429}.; FUNCTION: [Isoform 4]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}.; FUNCTION: [Isoform 5]: Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane. {ECO:0000269|PubMed:20974897}. |
| O75815 | BCAR3 | S269 | ochoa | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014). {ECO:0000250|UniProtKB:D3ZAZ5, ECO:0000250|UniProtKB:Q9QZK2, ECO:0000269|PubMed:18722344, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:22081014, ECO:0000269|PubMed:24216110}. |
| O75923 | DYSF | S1296 | ochoa | Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) | Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}. |
| O75970 | MPDZ | Y805 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O76080 | ZFAND5 | S82 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94967 | WDR47 | S395 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95149 | SNUPN | S340 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| O95983 | MBD3 | S24 | psp | Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| P04637 | TP53 | S33 | psp | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:35618207, ECO:0000269|PubMed:36634798, ECO:0000269|PubMed:38653238, ECO:0000269|PubMed:9840937}. |
| P05204 | HMGN2 | S25 | psp | Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). {ECO:0000250}. |
| P11388 | TOP2A | S1303 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P16144 | ITGB4 | S1209 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16615 | ATP2A2 | S555 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P18583 | SON | S90 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P21359 | NF1 | S2495 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P24593 | IGFBP5 | S125 | ochoa | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}. |
| P26010 | ITGB7 | S774 | ochoa | Integrin beta-7 (Gut homing receptor beta subunit) | Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract (PubMed:10837471, PubMed:14608374). Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin (PubMed:10837471). {ECO:0000269|PubMed:10837471, ECO:0000269|PubMed:14608374, ECO:0000305|PubMed:12297042}.; FUNCTION: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. {ECO:0000269|PubMed:18264102}. |
| P27815 | PDE4A | S302 | ochoa | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:2160582}.; FUNCTION: [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 2]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:15738310}.; FUNCTION: [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. {ECO:0000269|PubMed:7888306}.; FUNCTION: [Isoform 4]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:9677330}.; FUNCTION: [Isoform 6]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:17727341}.; FUNCTION: [Isoform 7]: Efficiently hydrolyzes cAMP. {ECO:0000269|PubMed:18095939}. |
| P27816 | MAP4 | S330 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27816 | MAP4 | S439 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28715 | ERCC5 | S311 | ochoa | DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein) | Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:26833090, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:32522879, ECO:0000269|PubMed:32821917, ECO:0000269|PubMed:7651464, ECO:0000269|PubMed:8078765, ECO:0000269|PubMed:8090225, ECO:0000269|PubMed:8206890, ECO:0000269|PubMed:9927729}. |
| P32119 | PRDX2 | S76 | psp | Peroxiredoxin-2 (EC 1.11.1.24) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}. |
| P34972 | CNR2 | S336 | ochoa|psp | Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}. |
| P35367 | HRH1 | S230 | ochoa | Histamine H1 receptor (H1-R) (H1R) (HH1R) | G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity). {ECO:0000250|UniProtKB:P70174, ECO:0000269|PubMed:33828102, ECO:0000269|PubMed:8280179}. |
| P40763 | STAT3 | S701 | ochoa | Signal transducer and activator of transcription 3 (Acute-phase response factor) | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:12359225, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:16285960, ECO:0000269|PubMed:17344214, ECO:0000269|PubMed:18242580, ECO:0000269|PubMed:18782771, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:28065600, ECO:0000269|PubMed:28262505, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:38404237}. |
| P41236 | PPP1R2 | S44 | psp | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P46821 | MAP1B | S1376 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | S1653 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49006 | MARCKSL1 | S165 | ochoa | MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}. |
| P50479 | PDLIM4 | S112 | ochoa | PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein) | [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). {ECO:0000250|UniProtKB:P36202, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:21636573}.; FUNCTION: [Isoform 2]: Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration. {ECO:0000269|PubMed:21636573}. |
| P51610 | HCFC1 | S2007 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51811 | XK | S416 | ochoa | Endoplasmic reticulum membrane adapter protein XK (Kell complex 37 kDa component) (Kx antigen) (Membrane transport protein XK) (XK-related protein 1) | Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane. {ECO:0000269|PubMed:32845802}. |
| P52597 | HNRNPF | S195 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P54707 | ATP12A | S499 | ochoa | Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) | The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:11341842, PubMed:7485470, PubMed:8853415, PubMed:9774385). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}. |
| P55011 | SLC12A2 | S132 | ochoa | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55265 | ADAR | S588 | ochoa | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P56211 | ARPP19 | S23 | ochoa | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P58004 | SESN2 | S73 | psp | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26586190, PubMed:26612684, PubMed:31586034, PubMed:35114100, PubMed:35831510, PubMed:36528027). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100, PubMed:35831510, PubMed:36528027). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821). {ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:18692468, ECO:0000269|PubMed:19113821, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:24947615, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:26612684, ECO:0000269|PubMed:35114100, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P61204 | ARF3 | S62 | ochoa | ADP-ribosylation factor 3 | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. |
| P78312 | FAM193A | S983 | ochoa | Protein FAM193A (Protein IT14) | None |
| P78347 | GTF2I | S547 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78559 | MAP1A | S1749 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P84077 | ARF1 | S62 | ochoa | ADP-ribosylation factor 1 (EC 3.6.5.2) | Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}. |
| P98175 | RBM10 | S710 | ochoa | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q00839 | HNRNPU | S187 | ochoa | Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120) | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:10490622, ECO:0000269|PubMed:10671544, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:11909954, ECO:0000269|PubMed:1324173, ECO:0000269|PubMed:15711563, ECO:0000269|PubMed:1628625, ECO:0000269|PubMed:17174306, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:22325991, ECO:0000269|PubMed:23811339, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:26244333, ECO:0000269|PubMed:28622508, ECO:0000269|PubMed:7509195, ECO:0000269|PubMed:8068679, ECO:0000269|PubMed:8174554, ECO:0000269|PubMed:9204873, ECO:0000269|PubMed:9353307, ECO:0000269|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269|PubMed:16916646}. |
| Q02388 | COL7A1 | S1966 | ochoa | Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen) | Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. |
| Q03164 | KMT2A | S2085 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05209 | PTPN12 | S324 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q07157 | TJP1 | S381 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07157 | TJP1 | S995 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q07817 | BCL2L1 | S49 | psp | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. |
| Q13002 | GRIK2 | S868 | psp | Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) | Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587, ECO:0000269|PubMed:7536611, ECO:0000269|PubMed:8730589}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}. |
| Q13207 | TBX2 | S368 | ochoa | T-box transcription factor TBX2 (T-box protein 2) | Transcription factor which acts as a transcriptional repressor (PubMed:11062467, PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203). {ECO:0000250|UniProtKB:Q60707, ECO:0000269|PubMed:11062467, ECO:0000269|PubMed:11111039, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537, ECO:0000269|PubMed:22844464, ECO:0000269|PubMed:28910203, ECO:0000269|PubMed:29726930, ECO:0000269|PubMed:30599067}. |
| Q13438 | OS9 | S217 | ochoa | Protein OS-9 (Amplified in osteosarcoma 9) | Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Possible targets include TRPV4 as well as hyperglycosylated HSP90B1 (PubMed:17932042). {ECO:0000269|PubMed:17932042, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021, ECO:0000269|PubMed:19346256, ECO:0000269|PubMed:21172656, ECO:0000269|PubMed:24899641}. |
| Q13501 | SQSTM1 | S182 | ochoa | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13625 | TP53BP2 | S682 | ochoa | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269|PubMed:11684014, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12694406, ECO:0000269|PubMed:19377511}. |
| Q14151 | SAFB2 | S330 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14155 | ARHGEF7 | S392 | ochoa | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Q14207 | NPAT | S381 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14676 | MDC1 | S376 | ochoa|psp | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S516 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | S955 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14680 | MELK | S505 | ochoa|psp | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14684 | RRP1B | S500 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14739 | LBR | S156 | ochoa | Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963). {ECO:0000250|UniProtKB:Q3U9G9, ECO:0000269|PubMed:10828963, ECO:0000269|PubMed:12618959, ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:21327084, ECO:0000269|PubMed:27336722, ECO:0000269|PubMed:9630650}. |
| Q14999 | CUL7 | S616 | ochoa | Cullin-7 (CUL-7) | Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:12481031, PubMed:12904573, PubMed:21572988, PubMed:21737058, PubMed:24793695, PubMed:35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed:21572988, PubMed:21737058, PubMed:24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328, PubMed:35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed:35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. {ECO:0000269|PubMed:12481031, ECO:0000269|PubMed:12904573, ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:21737058, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696, ECO:0000269|PubMed:35982156}. |
| Q15004 | PCLAF | S89 | ochoa | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) | PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. |
| Q15013 | MAD2L1BP | S37 | ochoa | MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet)) | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}. |
| Q15365 | PCBP1 | S85 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15365 | PCBP1 | S173 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15424 | SAFB | S331 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q15652 | JMJD1C | S1988 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15772 | SPEG | S513 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15910 | EZH2 | S408 | ochoa | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:16936726, ECO:0000269|PubMed:17210787, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:22323599, ECO:0000269|PubMed:23063525, ECO:0000269|PubMed:24474760, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:30923826}. |
| Q27J81 | INF2 | S1149 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2M1Z3 | ARHGAP31 | S1071 | ochoa | Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein) | Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:12192056, ECO:0000269|PubMed:16519628}. |
| Q32MZ4 | LRRFIP1 | S536 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q32P28 | P3H1 | S706 | ochoa | Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}. |
| Q3T8J9 | GON4L | S1258 | ochoa | GON-4-like protein (GON-4 homolog) | Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis. {ECO:0000250|UniProtKB:Q9DB00}. |
| Q53GS9 | USP39 | S42 | ochoa | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806). {ECO:0000250|UniProtKB:Q3TIX9, ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:18728397, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:30771428, ECO:0000269|PubMed:33127822, ECO:0000269|PubMed:34614178, ECO:0000269|PubMed:36651806}. |
| Q59EK9 | RUNDC3A | S381 | ochoa | RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8) | May act as an effector of RAP2A in neuronal cells. {ECO:0000250}. |
| Q5H9R7 | PPP6R3 | S823 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JQS6 | GCSAML | S62 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q5JYT7 | KIAA1755 | S548 | ochoa | Uncharacterized protein KIAA1755 | None |
| Q5T0Z8 | C6orf132 | S576 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1C6 | THEM4 | S37 | psp | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) | Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}. |
| Q68DK2 | ZFYVE26 | S1889 | ochoa | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20208530}. |
| Q68DK7 | MSL1 | S393 | ochoa | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). {ECO:0000250|UniProtKB:Q6PDM1, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q6DN90 | IQSEC1 | S198 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6EKJ0 | GTF2IRD2B | S205 | ochoa | General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) | None |
| Q6IE81 | JADE1 | S293 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6NXT6 | TAPT1 | S502 | ochoa | Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) | Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}. |
| Q6P1N0 | CC2D1A | S118 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6PJ61 | FBXO46 | S240 | ochoa | F-box only protein 46 (F-box only protein 34-like) | Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31 (PubMed:30171069). {ECO:0000269|PubMed:30171069}. |
| Q6R327 | RICTOR | S1588 | ochoa | Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250|UniProtKB:Q6QI06, ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:19720745, ECO:0000269|PubMed:19935711, ECO:0000269|PubMed:19995915, ECO:0000269|PubMed:21343617, ECO:0000269|PubMed:33158864, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:35926713}. |
| Q6ZUS6 | CCDC149 | S414 | ochoa | Coiled-coil domain-containing protein 149 | None |
| Q70CQ2 | USP34 | S3406 | ochoa | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269|PubMed:21383061}. |
| Q7Z2E3 | APTX | S158 | ochoa | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). {ECO:0000250|UniProtKB:O74859, ECO:0000269|PubMed:15044383, ECO:0000269|PubMed:15380105, ECO:0000269|PubMed:16547001, ECO:0000269|PubMed:16964241, ECO:0000269|PubMed:17276982, ECO:0000269|PubMed:24362567}. |
| Q7Z591 | AKNA | S1228 | ochoa | Microtubule organization protein AKNA (AT-hook-containing transcription factor) | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}. |
| Q7Z5J4 | RAI1 | S670 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q86SQ0 | PHLDB2 | S896 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UE4 | MTDH | S359 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86UP8 | GTF2IRD2 | S205 | ochoa | General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) | None |
| Q8IV04 | TBC1D10C | S19 | ochoa | Carabin (TBC1 domain family member 10C) | Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. {ECO:0000269|PubMed:17230191}. |
| Q8IVJ1 | SLC41A1 | S73 | ochoa | Solute carrier family 41 member 1 | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed:22031603, PubMed:23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity). {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}. |
| Q8IY92 | SLX4 | S1406 | ochoa | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. |
| Q8N1G4 | LRRC47 | S528 | ochoa | Leucine-rich repeat-containing protein 47 | None |
| Q8N6Q8 | METTL25 | S265 | ochoa | Probable methyltransferase-like protein 25 (EC 2.1.1.-) | Probable methyltransferase. {ECO:0000305}. |
| Q8N884 | CGAS | S221 | psp | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8NC24 | RELL2 | S187 | ochoa | RELT-like protein 2 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8NEN9 | PDZD8 | S519 | ochoa | PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29097544}. |
| Q8TD16 | BICD2 | S418 | ochoa | Protein bicaudal D homolog 2 (Bic-D 2) | Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:25814576, ECO:0000269|PubMed:25962623}. |
| Q8TF72 | SHROOM3 | S540 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8TF72 | SHROOM3 | S749 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUA4 | GTF3C2 | S85 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WUQ7 | CACTIN | S476 | ochoa | Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) | Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851). Involved in the regulation of innate immune response (PubMed:20829348). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554). {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}. |
| Q8WW12 | PCNP | S48 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WXH0 | SYNE2 | S4123 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92508 | PIEZO1 | S392 | ochoa | Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (PubMed:25955826). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (PubMed:25955826). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). {ECO:0000250|UniProtKB:E2JF22, ECO:0000250|UniProtKB:Q91X60, ECO:0000269|PubMed:25955826, ECO:0000269|PubMed:29799007}. |
| Q92615 | LARP4B | S511 | ochoa | La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) | Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}. |
| Q92934 | BAD | S118 | ochoa|psp | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}. |
| Q93073 | SECISBP2L | S270 | ochoa | Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) | Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro. |
| Q96CC6 | RHBDF1 | S128 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96GX5 | MASTL | S512 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q96HS1 | PGAM5 | S171 | ochoa | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) | Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}. |
| Q96IZ0 | PAWR | S116 | ochoa | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. |
| Q96JB2 | COG3 | S527 | ochoa | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269|PubMed:11929878, ECO:0000269|PubMed:37711075}. |
| Q96JB3 | HIC2 | S348 | ochoa | Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30) | Transcriptional repressor. |
| Q96N46 | TTC14 | S733 | ochoa | Tetratricopeptide repeat protein 14 (TPR repeat protein 14) | None |
| Q96T58 | SPEN | S1006 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T58 | SPEN | S1261 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q9BQ67 | GRWD1 | S25 | ochoa | Glutamate-rich WD repeat-containing protein 1 | Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}. |
| Q9BRG2 | SH2D3A | S225 | ochoa | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | May play a role in JNK activation. |
| Q9BVG8 | KIFC3 | S783 | ochoa | Kinesin-like protein KIFC3 | Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}. |
| Q9BW04 | SARG | S556 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BX66 | SORBS1 | S1230 | ochoa | Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Q9BXL5 | HEMGN | S201 | ochoa | Hemogen (Erythroid differentiation-associated gene protein) (EDAG-1) (Hemopoietic gene protein) (Negative differentiation regulator protein) | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}. |
| Q9BXL6 | CARD14 | S500 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BYW2 | SETD2 | S1844 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Q9GZR2 | REXO4 | S131 | ochoa | RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) | None |
| Q9GZV5 | WWTR1 | S60 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H257 | CARD9 | S450 | ochoa | Caspase recruitment domain-containing protein 9 (hCARD9) | Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25057046, PubMed:25702837, PubMed:26521038, PubMed:26679537, PubMed:26961233, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:26961233, PubMed:31296852, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}. |
| Q9H3Z4 | DNAJC5 | S161 | ochoa | DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP) | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250|UniProtKB:P60904, ECO:0000250|UniProtKB:Q29455}. |
| Q9H6W3 | RIOX1 | S66 | ochoa | Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.27, EC 1.14.11.79) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX) | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (PubMed:23103944). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) (By similarity). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (PubMed:23103944). Participates in MYC-induced transcriptional activation (PubMed:17308053). {ECO:0000250|UniProtKB:Q9JJF3, ECO:0000269|PubMed:17308053, ECO:0000269|PubMed:23103944}. |
| Q9H7N4 | SCAF1 | S965 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H869 | YY1AP1 | S714 | ochoa | YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2) | Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}. |
| Q9HCE3 | ZNF532 | S294 | ochoa | Zinc finger protein 532 | May be involved in transcriptional regulation. |
| Q9HCE6 | ARHGEF10L | S708 | ochoa | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. {ECO:0000269|PubMed:16112081}. |
| Q9HCH5 | SYTL2 | S535 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCM7 | FBRSL1 | S937 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQ75 | CASS4 | S93 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQW6 | ANLN | S388 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR30 | DDX21 | S458 | ochoa | Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) | RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250|UniProtKB:Q9JIK5, ECO:0000269|PubMed:11823437, ECO:0000269|PubMed:14559904, ECO:0000269|PubMed:18180292, ECO:0000269|PubMed:25260534, ECO:0000269|PubMed:25470060, ECO:0000269|PubMed:25477391, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}. |
| Q9NUL3 | STAU2 | S395 | ochoa | Double-stranded RNA-binding protein Staufen homolog 2 | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250|UniProtKB:Q68SB1}. |
| Q9NWS0 | PIH1D1 | Y194 | ochoa | PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog) | Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}. |
| Q9NX95 | SYBU | S128 | ochoa | Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) | Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:15459722}. |
| Q9P270 | SLAIN2 | S323 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2D6 | FAM135A | S636 | ochoa | Protein FAM135A | None |
| Q9UDY8 | MALT1 | S573 | psp | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}. |
| Q9UHK6 | AMACR | S324 | ochoa | Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) | Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}. |
| Q9UKE5 | TNIK | S659 | ochoa | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}. |
| Q9ULV4 | CORO1C | S299 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9UPV0 | CEP164 | S270 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ35 | SRRM2 | S317 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y450 | HBS1L | S189 | ochoa | HBS1-like protein (EC 3.6.5.-) (ERFS) | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:32006463}. |
| Q9Y4B5 | MTCL1 | S1434 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y6J0 | CABIN1 | S1442 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| Q9Y6J0 | CABIN1 | S1764 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| R4GMW8 | BIVM-ERCC5 | S765 | ochoa | DNA excision repair protein ERCC-5 | None |
| Q92796 | DLG3 | S615 | Sugiyama | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. |
| Q7Z7G1 | CLNK | S331 | Sugiyama | Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer) | An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9QZE2}. |
| Q14192 | FHL2 | S121 | Sugiyama | Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}. |
| P00519 | ABL1 | S642 | Sugiyama | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P42261 | GRIA1 | S832 | SIGNOR | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1311100, ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28628100, ECO:0000269|PubMed:35675825}. |
| P29322 | EPHA8 | S643 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| P51957 | NEK4 | S631 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P19174 | PLCG1 | S672 | Sugiyama | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). {ECO:0000250|UniProtKB:P10686, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:37422272}. |
| Q99558 | MAP3K14 | S841 | Sugiyama | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:25406581}. |
| Q9NQU5 | PAK6 | S189 | Sugiyama | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | 0.000016 | 4.783 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.000242 | 3.616 |
| R-HSA-451308 | Activation of Ca-permeable Kainate Receptor | 0.000746 | 3.127 |
| R-HSA-451306 | Ionotropic activity of kainate receptors | 0.000923 | 3.035 |
| R-HSA-6804754 | Regulation of TP53 Expression | 0.001358 | 2.867 |
| R-HSA-9723907 | Loss of Function of TP53 in Cancer | 0.013202 | 1.879 |
| R-HSA-9723905 | Loss of function of TP53 in cancer due to loss of tetramerization ability | 0.013202 | 1.879 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.011399 | 1.943 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.021910 | 1.659 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.008175 | 2.088 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.021910 | 1.659 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.028633 | 1.543 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.024352 | 1.613 |
| R-HSA-202433 | Generation of second messenger molecules | 0.025406 | 1.595 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.029552 | 1.529 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.013875 | 1.858 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.010892 | 1.963 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.012778 | 1.894 |
| R-HSA-72172 | mRNA Splicing | 0.010829 | 1.965 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.023888 | 1.622 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.018503 | 1.733 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.029099 | 1.536 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.026230 | 1.581 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.017354 | 1.761 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.016744 | 1.776 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.024046 | 1.619 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.012684 | 1.897 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.026901 | 1.570 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.019576 | 1.708 |
| R-HSA-202403 | TCR signaling | 0.024363 | 1.613 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.008054 | 2.094 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.017713 | 1.752 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.019016 | 1.721 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.004307 | 2.366 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.005245 | 2.280 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.028246 | 1.549 |
| R-HSA-2559583 | Cellular Senescence | 0.005542 | 2.256 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.023695 | 1.625 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.004085 | 2.389 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 0.010056 | 1.998 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.019016 | 1.721 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.027092 | 1.567 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.016454 | 1.784 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.021910 | 1.659 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.012684 | 1.897 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.009648 | 2.016 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.007421 | 2.130 |
| R-HSA-109581 | Apoptosis | 0.003067 | 2.513 |
| R-HSA-4839726 | Chromatin organization | 0.010518 | 1.978 |
| R-HSA-5357801 | Programmed Cell Death | 0.011099 | 1.955 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.016946 | 1.771 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.026590 | 1.575 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.032303 | 1.491 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.032303 | 1.491 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.032471 | 1.489 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.032303 | 1.491 |
| R-HSA-9833482 | PKR-mediated signaling | 0.030766 | 1.512 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.032790 | 1.484 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 0.039088 | 1.408 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 0.039088 | 1.408 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 0.051776 | 1.286 |
| R-HSA-4755609 | Defective DHDDS causes RP59 | 0.051776 | 1.286 |
| R-HSA-8875791 | MET activates STAT3 | 0.064297 | 1.192 |
| R-HSA-167021 | PLC-gamma1 signalling | 0.064297 | 1.192 |
| R-HSA-9034793 | Activated NTRK3 signals through PLCG1 | 0.064297 | 1.192 |
| R-HSA-451307 | Activation of Na-permeable kainate receptors | 0.064297 | 1.192 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.064297 | 1.192 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.064297 | 1.192 |
| R-HSA-198745 | Signalling to STAT3 | 0.064297 | 1.192 |
| R-HSA-9026527 | Activated NTRK2 signals through PLCG1 | 0.076654 | 1.115 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.076654 | 1.115 |
| R-HSA-399710 | Activation of AMPA receptors | 0.088849 | 1.051 |
| R-HSA-68911 | G2 Phase | 0.088849 | 1.051 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.112759 | 0.948 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.124479 | 0.905 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.136044 | 0.866 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.136044 | 0.866 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.158722 | 0.799 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.050728 | 1.295 |
| R-HSA-2214320 | Anchoring fibril formation | 0.180806 | 0.743 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.180806 | 0.743 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.202314 | 0.694 |
| R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 0.212856 | 0.672 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.223259 | 0.651 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.223259 | 0.651 |
| R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 0.223259 | 0.651 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 0.253655 | 0.596 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.263522 | 0.579 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 0.282867 | 0.548 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.301707 | 0.520 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.301707 | 0.520 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.194913 | 0.710 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.258127 | 0.588 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.129884 | 0.886 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.129884 | 0.886 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.346678 | 0.460 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.360111 | 0.444 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.072014 | 1.143 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.310941 | 0.507 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.302175 | 0.520 |
| R-HSA-191650 | Regulation of gap junction activity | 0.076654 | 1.115 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 0.100883 | 0.996 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.243657 | 0.613 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.310941 | 0.507 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.355320 | 0.449 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.054092 | 1.267 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.089247 | 1.049 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.310941 | 0.507 |
| R-HSA-2424491 | DAP12 signaling | 0.083558 | 1.078 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.233526 | 0.632 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.166458 | 0.779 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.138845 | 0.857 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.086704 | 1.062 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 0.088849 | 1.051 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.263522 | 0.579 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.171365 | 0.766 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.196989 | 0.706 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.076654 | 1.115 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.076654 | 1.115 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.088849 | 1.051 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.214206 | 0.669 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.190125 | 0.721 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.212856 | 0.672 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.055626 | 1.255 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.051776 | 1.286 |
| R-HSA-75102 | C6 deamination of adenosine | 0.051776 | 1.286 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.076654 | 1.115 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 0.100883 | 0.996 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.136044 | 0.866 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.136044 | 0.866 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.038090 | 1.419 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.191631 | 0.718 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.202314 | 0.694 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.223259 | 0.651 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.095619 | 1.019 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.329046 | 0.483 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.233526 | 0.632 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.041234 | 1.385 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.320054 | 0.495 |
| R-HSA-3928664 | Ephrin signaling | 0.263522 | 0.579 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 0.301707 | 0.520 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.314305 | 0.503 |
| R-HSA-9620244 | Long-term potentiation | 0.064636 | 1.190 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 0.372265 | 0.429 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.282623 | 0.549 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.202314 | 0.694 |
| R-HSA-5694530 | Cargo concentration in the ER | 0.087524 | 1.058 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.075562 | 1.122 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.151723 | 0.819 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.076654 | 1.115 |
| R-HSA-111448 | Activation of NOXA and translocation to mitochondria | 0.076654 | 1.115 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.147458 | 0.831 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.112406 | 0.949 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.185354 | 0.732 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.204534 | 0.689 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.345765 | 0.461 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.341544 | 0.467 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.127901 | 0.893 |
| R-HSA-8985947 | Interleukin-9 signaling | 0.136044 | 0.866 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.076319 | 1.117 |
| R-HSA-201556 | Signaling by ALK | 0.125456 | 0.902 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.194913 | 0.710 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.267927 | 0.572 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.075562 | 1.122 |
| R-HSA-2172127 | DAP12 interactions | 0.152527 | 0.817 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.310941 | 0.507 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.267927 | 0.572 |
| R-HSA-525793 | Myogenesis | 0.068292 | 1.166 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.332559 | 0.478 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.247170 | 0.607 |
| R-HSA-165158 | Activation of AKT2 | 0.088849 | 1.051 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.112759 | 0.948 |
| R-HSA-75072 | mRNA Editing | 0.147458 | 0.831 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.147458 | 0.831 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 0.158722 | 0.799 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.180806 | 0.743 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.223259 | 0.651 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 0.273259 | 0.563 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.273259 | 0.563 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.337921 | 0.471 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.238551 | 0.622 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.297294 | 0.527 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.345765 | 0.461 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.047924 | 1.319 |
| R-HSA-1474290 | Collagen formation | 0.161712 | 0.791 |
| R-HSA-9664873 | Pexophagy | 0.158722 | 0.799 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.079510 | 1.100 |
| R-HSA-1059683 | Interleukin-6 signaling | 0.202314 | 0.694 |
| R-HSA-8983432 | Interleukin-15 signaling | 0.191631 | 0.718 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.187803 | 0.726 |
| R-HSA-390650 | Histamine receptors | 0.064297 | 1.192 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.212856 | 0.672 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.054606 | 1.263 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.301707 | 0.520 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.197742 | 0.704 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.095619 | 1.019 |
| R-HSA-2028269 | Signaling by Hippo | 0.035150 | 1.454 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.063080 | 1.200 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.277726 | 0.556 |
| R-HSA-2586552 | Signaling by Leptin | 0.158722 | 0.799 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.108140 | 0.966 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.191139 | 0.719 |
| R-HSA-844455 | The NLRP1 inflammasome | 0.064297 | 1.192 |
| R-HSA-447038 | NrCAM interactions | 0.088849 | 1.051 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.124479 | 0.905 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.038090 | 1.419 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.158722 | 0.799 |
| R-HSA-428540 | Activation of RAC1 | 0.180806 | 0.743 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.191631 | 0.718 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.191631 | 0.718 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 0.202314 | 0.694 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.212856 | 0.672 |
| R-HSA-186763 | Downstream signal transduction | 0.087524 | 1.058 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.243657 | 0.613 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.243657 | 0.613 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.301707 | 0.520 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.326480 | 0.486 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.296801 | 0.528 |
| R-HSA-182971 | EGFR downregulation | 0.087524 | 1.058 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.372265 | 0.429 |
| R-HSA-449147 | Signaling by Interleukins | 0.091769 | 1.037 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.124479 | 0.905 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.169837 | 0.770 |
| R-HSA-3000157 | Laminin interactions | 0.064636 | 1.190 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 0.212856 | 0.672 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.355320 | 0.449 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.363849 | 0.439 |
| R-HSA-3214847 | HATs acetylate histones | 0.181178 | 0.742 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.306228 | 0.514 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.223920 | 0.650 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.097060 | 1.013 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.363849 | 0.439 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.288752 | 0.539 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.238551 | 0.622 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.068292 | 1.166 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.263522 | 0.579 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.136855 | 0.864 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.112800 | 0.948 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.329046 | 0.483 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.248332 | 0.605 |
| R-HSA-5205647 | Mitophagy | 0.103919 | 0.983 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.238528 | 0.622 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 0.100883 | 0.996 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.100883 | 0.996 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.044239 | 1.354 |
| R-HSA-5578768 | Physiological factors | 0.212856 | 0.672 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.243657 | 0.613 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.253655 | 0.596 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.253655 | 0.596 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.253655 | 0.596 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.168690 | 0.773 |
| R-HSA-186797 | Signaling by PDGF | 0.067533 | 1.170 |
| R-HSA-177929 | Signaling by EGFR | 0.054606 | 1.263 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.301707 | 0.520 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.134347 | 0.872 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.310941 | 0.507 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.329046 | 0.483 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.230789 | 0.637 |
| R-HSA-397014 | Muscle contraction | 0.371522 | 0.430 |
| R-HSA-73894 | DNA Repair | 0.243470 | 0.614 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.158722 | 0.799 |
| R-HSA-210990 | PECAM1 interactions | 0.169837 | 0.770 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 0.223259 | 0.651 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 0.223259 | 0.651 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.346678 | 0.460 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 0.355320 | 0.449 |
| R-HSA-9663891 | Selective autophagy | 0.369612 | 0.432 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.055953 | 1.252 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.086704 | 1.062 |
| R-HSA-1280218 | Adaptive Immune System | 0.254194 | 0.595 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.340959 | 0.467 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.263522 | 0.579 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.292349 | 0.534 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.292349 | 0.534 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 0.372265 | 0.429 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.326480 | 0.486 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.076516 | 1.116 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.191631 | 0.718 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.075801 | 1.120 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.273259 | 0.563 |
| R-HSA-446199 | Synthesis of dolichyl-phosphate | 0.329046 | 0.483 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.372265 | 0.429 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.372265 | 0.429 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.152527 | 0.817 |
| R-HSA-69236 | G1 Phase | 0.152527 | 0.817 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.292349 | 0.534 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.068561 | 1.164 |
| R-HSA-73887 | Death Receptor Signaling | 0.081031 | 1.091 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.372265 | 0.429 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.191631 | 0.718 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.337921 | 0.471 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.121066 | 0.917 |
| R-HSA-1640170 | Cell Cycle | 0.108792 | 0.963 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.083558 | 1.078 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.057534 | 1.240 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.191631 | 0.718 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.103919 | 0.983 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.355320 | 0.449 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.040032 | 1.398 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.228790 | 0.641 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.232218 | 0.634 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.235715 | 0.628 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.039452 | 1.404 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.273259 | 0.563 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.256276 | 0.591 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.136044 | 0.866 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.050728 | 1.295 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.212856 | 0.672 |
| R-HSA-9629569 | Protein hydroxylation | 0.282867 | 0.548 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.081031 | 1.091 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.088643 | 1.052 |
| R-HSA-8953854 | Metabolism of RNA | 0.250186 | 0.602 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.112406 | 0.949 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.253655 | 0.596 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.273259 | 0.563 |
| R-HSA-5662702 | Melanin biosynthesis | 0.282867 | 0.548 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 0.310941 | 0.507 |
| R-HSA-389887 | Beta-oxidation of pristanoyl-CoA | 0.337921 | 0.471 |
| R-HSA-5693538 | Homology Directed Repair | 0.256879 | 0.590 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.243281 | 0.614 |
| R-HSA-2262752 | Cellular responses to stress | 0.152039 | 0.818 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.062062 | 1.207 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.061049 | 1.214 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.072014 | 1.143 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.301707 | 0.520 |
| R-HSA-5620971 | Pyroptosis | 0.363849 | 0.439 |
| R-HSA-180024 | DARPP-32 events | 0.372265 | 0.429 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.139886 | 0.854 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.355320 | 0.449 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.208793 | 0.680 |
| R-HSA-1538133 | G0 and Early G1 | 0.091545 | 1.038 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.320054 | 0.495 |
| R-HSA-6807070 | PTEN Regulation | 0.343210 | 0.464 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.253655 | 0.596 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.134347 | 0.872 |
| R-HSA-3000170 | Syndecan interactions | 0.320054 | 0.495 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.316781 | 0.499 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.316781 | 0.499 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.072125 | 1.142 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.326480 | 0.486 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.246260 | 0.609 |
| R-HSA-194138 | Signaling by VEGF | 0.285468 | 0.544 |
| R-HSA-216083 | Integrin cell surface interactions | 0.316781 | 0.499 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.136855 | 0.864 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.320054 | 0.495 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.106944 | 0.971 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.329046 | 0.483 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.329046 | 0.483 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.175802 | 0.755 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.112406 | 0.949 |
| R-HSA-391251 | Protein folding | 0.155373 | 0.809 |
| R-HSA-622312 | Inflammasomes | 0.363849 | 0.439 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.360111 | 0.444 |
| R-HSA-202424 | Downstream TCR signaling | 0.379056 | 0.421 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.380570 | 0.420 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.380570 | 0.420 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.380570 | 0.420 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.380570 | 0.420 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 0.380570 | 0.420 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.380570 | 0.420 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.383757 | 0.416 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.386346 | 0.413 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.388442 | 0.411 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.388766 | 0.410 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.393112 | 0.405 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.396854 | 0.401 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.396854 | 0.401 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.396854 | 0.401 |
| R-HSA-199991 | Membrane Trafficking | 0.397858 | 0.400 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.404835 | 0.393 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.404835 | 0.393 |
| R-HSA-9930044 | Nuclear RNA decay | 0.404835 | 0.393 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.404835 | 0.393 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.404835 | 0.393 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.404835 | 0.393 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.404835 | 0.393 |
| R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 0.404835 | 0.393 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.412712 | 0.384 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.412712 | 0.384 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.416211 | 0.381 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.420484 | 0.376 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.420484 | 0.376 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.420484 | 0.376 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.420484 | 0.376 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.420484 | 0.376 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.420778 | 0.376 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.425328 | 0.371 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.425328 | 0.371 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.425328 | 0.371 |
| R-HSA-190236 | Signaling by FGFR | 0.425328 | 0.371 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.428154 | 0.368 |
| R-HSA-169911 | Regulation of Apoptosis | 0.428154 | 0.368 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 0.428154 | 0.368 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 0.428154 | 0.368 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.428154 | 0.368 |
| R-HSA-212436 | Generic Transcription Pathway | 0.433502 | 0.363 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.435723 | 0.361 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.435723 | 0.361 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.435723 | 0.361 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.435723 | 0.361 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.435723 | 0.361 |
| R-HSA-8853659 | RET signaling | 0.435723 | 0.361 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.435723 | 0.361 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.443193 | 0.353 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.443193 | 0.353 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.443193 | 0.353 |
| R-HSA-8948216 | Collagen chain trimerization | 0.443193 | 0.353 |
| R-HSA-1483255 | PI Metabolism | 0.443337 | 0.353 |
| R-HSA-913531 | Interferon Signaling | 0.449302 | 0.347 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.450564 | 0.346 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.456638 | 0.340 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.456638 | 0.340 |
| R-HSA-69541 | Stabilization of p53 | 0.457837 | 0.339 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.457837 | 0.339 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.457837 | 0.339 |
| R-HSA-9648002 | RAS processing | 0.457837 | 0.339 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.457837 | 0.339 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.461031 | 0.336 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.465015 | 0.333 |
| R-HSA-5260271 | Diseases of Immune System | 0.465015 | 0.333 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.465015 | 0.333 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.465015 | 0.333 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.465015 | 0.333 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.472099 | 0.326 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.472099 | 0.326 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.472099 | 0.326 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.474086 | 0.324 |
| R-HSA-112316 | Neuronal System | 0.474455 | 0.324 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.476956 | 0.322 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.478395 | 0.320 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.479089 | 0.320 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.482683 | 0.316 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.482683 | 0.316 |
| R-HSA-74160 | Gene expression (Transcription) | 0.485086 | 0.314 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.485987 | 0.313 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.491194 | 0.309 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.492794 | 0.307 |
| R-HSA-9710421 | Defective pyroptosis | 0.492794 | 0.307 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.492794 | 0.307 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.492794 | 0.307 |
| R-HSA-8854214 | TBC/RABGAPs | 0.492794 | 0.307 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.495416 | 0.305 |
| R-HSA-373752 | Netrin-1 signaling | 0.499511 | 0.301 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.499511 | 0.301 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.506140 | 0.296 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.506140 | 0.296 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.506140 | 0.296 |
| R-HSA-774815 | Nucleosome assembly | 0.506140 | 0.296 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.506140 | 0.296 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.506140 | 0.296 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.506140 | 0.296 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.506140 | 0.296 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.506140 | 0.296 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.507949 | 0.294 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.512081 | 0.291 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.512081 | 0.291 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.512681 | 0.290 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.512681 | 0.290 |
| R-HSA-75153 | Apoptotic execution phase | 0.512681 | 0.290 |
| R-HSA-69275 | G2/M Transition | 0.513448 | 0.290 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.519136 | 0.285 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.519136 | 0.285 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.524342 | 0.280 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.525506 | 0.279 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.525506 | 0.279 |
| R-HSA-425410 | Metal ion SLC transporters | 0.525506 | 0.279 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.528383 | 0.277 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.528383 | 0.277 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.528383 | 0.277 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.531792 | 0.274 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.531792 | 0.274 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.531792 | 0.274 |
| R-HSA-73893 | DNA Damage Bypass | 0.531792 | 0.274 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.531792 | 0.274 |
| R-HSA-68875 | Mitotic Prophase | 0.532401 | 0.274 |
| R-HSA-73886 | Chromosome Maintenance | 0.536395 | 0.271 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.537995 | 0.269 |
| R-HSA-109704 | PI3K Cascade | 0.537995 | 0.269 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.537995 | 0.269 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.540366 | 0.267 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.540366 | 0.267 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.544116 | 0.264 |
| R-HSA-9864848 | Complex IV assembly | 0.544116 | 0.264 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.550157 | 0.260 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.550157 | 0.260 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.556015 | 0.255 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.556015 | 0.255 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.556015 | 0.255 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.556118 | 0.255 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.556118 | 0.255 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.556118 | 0.255 |
| R-HSA-1221632 | Meiotic synapsis | 0.556118 | 0.255 |
| R-HSA-69481 | G2/M Checkpoints | 0.563698 | 0.249 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.567503 | 0.246 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.567805 | 0.246 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.573533 | 0.241 |
| R-HSA-75893 | TNF signaling | 0.573533 | 0.241 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.573533 | 0.241 |
| R-HSA-5578775 | Ion homeostasis | 0.573533 | 0.241 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 0.573533 | 0.241 |
| R-HSA-112399 | IRS-mediated signalling | 0.579185 | 0.237 |
| R-HSA-9843745 | Adipogenesis | 0.582486 | 0.235 |
| R-HSA-5576891 | Cardiac conduction | 0.582486 | 0.235 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.584763 | 0.233 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.584763 | 0.233 |
| R-HSA-9909396 | Circadian clock | 0.586172 | 0.232 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.589082 | 0.230 |
| R-HSA-191859 | snRNP Assembly | 0.590267 | 0.229 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.590267 | 0.229 |
| R-HSA-9033241 | Peroxisomal protein import | 0.590267 | 0.229 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.590267 | 0.229 |
| R-HSA-180786 | Extension of Telomeres | 0.590267 | 0.229 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.595699 | 0.225 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.595699 | 0.225 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.599799 | 0.222 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.601059 | 0.221 |
| R-HSA-1442490 | Collagen degradation | 0.601059 | 0.221 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.601059 | 0.221 |
| R-HSA-450294 | MAP kinase activation | 0.601059 | 0.221 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.602186 | 0.220 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.606348 | 0.217 |
| R-HSA-9707616 | Heme signaling | 0.606348 | 0.217 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.606348 | 0.217 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.606701 | 0.217 |
| R-HSA-168256 | Immune System | 0.607866 | 0.216 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.611568 | 0.214 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.611568 | 0.214 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.611568 | 0.214 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.611568 | 0.214 |
| R-HSA-8848021 | Signaling by PTK6 | 0.611568 | 0.214 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.611568 | 0.214 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.614795 | 0.211 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.616719 | 0.210 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.616719 | 0.210 |
| R-HSA-1632852 | Macroautophagy | 0.621711 | 0.206 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.621801 | 0.206 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.631766 | 0.199 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.631766 | 0.199 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.635256 | 0.197 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.636650 | 0.196 |
| R-HSA-5218859 | Regulated Necrosis | 0.636650 | 0.196 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.646226 | 0.190 |
| R-HSA-448424 | Interleukin-17 signaling | 0.646226 | 0.190 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.646226 | 0.190 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.648420 | 0.188 |
| R-HSA-166520 | Signaling by NTRKs | 0.648420 | 0.188 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.650919 | 0.186 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.650919 | 0.186 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.654860 | 0.184 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.655550 | 0.183 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.660120 | 0.180 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.667116 | 0.176 |
| R-HSA-380287 | Centrosome maturation | 0.669079 | 0.175 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.669079 | 0.175 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.669079 | 0.175 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.669079 | 0.175 |
| R-HSA-1989781 | PPARA activates gene expression | 0.670550 | 0.174 |
| R-HSA-157118 | Signaling by NOTCH | 0.673030 | 0.172 |
| R-HSA-5689603 | UCH proteinases | 0.673471 | 0.172 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.673471 | 0.172 |
| R-HSA-9612973 | Autophagy | 0.673619 | 0.172 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.676664 | 0.170 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.679686 | 0.168 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.682080 | 0.166 |
| R-HSA-5619084 | ABC transporter disorders | 0.682080 | 0.166 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.682080 | 0.166 |
| R-HSA-9659379 | Sensory processing of sound | 0.686300 | 0.163 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.686300 | 0.163 |
| R-HSA-1474244 | Extracellular matrix organization | 0.687633 | 0.163 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.690463 | 0.161 |
| R-HSA-6806834 | Signaling by MET | 0.690463 | 0.161 |
| R-HSA-9675108 | Nervous system development | 0.692961 | 0.159 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.694572 | 0.158 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.694572 | 0.158 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.698627 | 0.156 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.702628 | 0.153 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.706576 | 0.151 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 0.706576 | 0.151 |
| R-HSA-5688426 | Deubiquitination | 0.709264 | 0.149 |
| R-HSA-1500620 | Meiosis | 0.710471 | 0.148 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.710471 | 0.148 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.714316 | 0.146 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.718109 | 0.144 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.720502 | 0.142 |
| R-HSA-70268 | Pyruvate metabolism | 0.721853 | 0.142 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.724973 | 0.140 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.725547 | 0.139 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.727616 | 0.138 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.729192 | 0.137 |
| R-HSA-597592 | Post-translational protein modification | 0.730380 | 0.136 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.732789 | 0.135 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.732789 | 0.135 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.736338 | 0.133 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.736338 | 0.133 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.741102 | 0.130 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.743297 | 0.129 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.750073 | 0.125 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.750453 | 0.125 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.753394 | 0.123 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.753394 | 0.123 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.763095 | 0.117 |
| R-HSA-157579 | Telomere Maintenance | 0.763095 | 0.117 |
| R-HSA-983712 | Ion channel transport | 0.764751 | 0.116 |
| R-HSA-422475 | Axon guidance | 0.765835 | 0.116 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.766243 | 0.116 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.769350 | 0.114 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.769358 | 0.114 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.772416 | 0.112 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.778427 | 0.109 |
| R-HSA-111885 | Opioid Signalling | 0.784279 | 0.106 |
| R-HSA-68886 | M Phase | 0.785000 | 0.105 |
| R-HSA-9833110 | RSV-host interactions | 0.787147 | 0.104 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.789978 | 0.102 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.792771 | 0.101 |
| R-HSA-418346 | Platelet homeostasis | 0.792771 | 0.101 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.795383 | 0.099 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.798246 | 0.098 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.798246 | 0.098 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.803577 | 0.095 |
| R-HSA-162582 | Signal Transduction | 0.808325 | 0.092 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.808768 | 0.092 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.816300 | 0.088 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.821156 | 0.086 |
| R-HSA-373760 | L1CAM interactions | 0.823536 | 0.084 |
| R-HSA-1500931 | Cell-Cell communication | 0.825446 | 0.083 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.825885 | 0.083 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.825885 | 0.083 |
| R-HSA-8951664 | Neddylation | 0.831313 | 0.080 |
| R-HSA-8957322 | Metabolism of steroids | 0.837302 | 0.077 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.839337 | 0.076 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.839337 | 0.076 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.841476 | 0.075 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.843055 | 0.074 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.847725 | 0.072 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.855677 | 0.068 |
| R-HSA-1474165 | Reproduction | 0.857599 | 0.067 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 0.859496 | 0.066 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.861368 | 0.065 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.872089 | 0.059 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.873794 | 0.059 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.873794 | 0.059 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.877136 | 0.057 |
| R-HSA-9664407 | Parasite infection | 0.877136 | 0.057 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.877136 | 0.057 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.878774 | 0.056 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.881985 | 0.055 |
| R-HSA-9679506 | SARS-CoV Infections | 0.883289 | 0.054 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.883559 | 0.054 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.885435 | 0.053 |
| R-HSA-9609507 | Protein localization | 0.898190 | 0.047 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 0.903516 | 0.044 |
| R-HSA-9711097 | Cellular response to starvation | 0.904804 | 0.043 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.906025 | 0.043 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.907328 | 0.042 |
| R-HSA-446728 | Cell junction organization | 0.907538 | 0.042 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.910489 | 0.041 |
| R-HSA-9658195 | Leishmania infection | 0.910489 | 0.041 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.911453 | 0.040 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.915335 | 0.038 |
| R-HSA-168249 | Innate Immune System | 0.915635 | 0.038 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.920067 | 0.036 |
| R-HSA-418555 | G alpha (s) signalling events | 0.921134 | 0.036 |
| R-HSA-1266738 | Developmental Biology | 0.921877 | 0.035 |
| R-HSA-1483257 | Phospholipid metabolism | 0.923134 | 0.035 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.923227 | 0.035 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.923227 | 0.035 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.923227 | 0.035 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.923227 | 0.035 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.925265 | 0.034 |
| R-HSA-195721 | Signaling by WNT | 0.925616 | 0.034 |
| R-HSA-611105 | Respiratory electron transport | 0.928221 | 0.032 |
| R-HSA-3781865 | Diseases of glycosylation | 0.933789 | 0.030 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.935548 | 0.029 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.937260 | 0.028 |
| R-HSA-5617833 | Cilium Assembly | 0.938926 | 0.027 |
| R-HSA-68877 | Mitotic Prometaphase | 0.941344 | 0.026 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.941644 | 0.026 |
| R-HSA-9609690 | HCMV Early Events | 0.943667 | 0.025 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.943667 | 0.025 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.953850 | 0.021 |
| R-HSA-68882 | Mitotic Anaphase | 0.957554 | 0.019 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.957827 | 0.019 |
| R-HSA-392499 | Metabolism of proteins | 0.957915 | 0.019 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.958123 | 0.019 |
| R-HSA-418990 | Adherens junctions interactions | 0.958684 | 0.018 |
| R-HSA-109582 | Hemostasis | 0.958869 | 0.018 |
| R-HSA-162906 | HIV Infection | 0.963408 | 0.016 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.964383 | 0.016 |
| R-HSA-72312 | rRNA processing | 0.965796 | 0.015 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.968029 | 0.014 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.972069 | 0.012 |
| R-HSA-9609646 | HCMV Infection | 0.973179 | 0.012 |
| R-HSA-421270 | Cell-cell junction organization | 0.973539 | 0.012 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.975906 | 0.011 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.977503 | 0.010 |
| R-HSA-372790 | Signaling by GPCR | 0.977760 | 0.010 |
| R-HSA-416476 | G alpha (q) signalling events | 0.977805 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 0.978540 | 0.009 |
| R-HSA-8978868 | Fatty acid metabolism | 0.978540 | 0.009 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.980614 | 0.009 |
| R-HSA-382551 | Transport of small molecules | 0.981359 | 0.008 |
| R-HSA-388396 | GPCR downstream signalling | 0.981930 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 0.987057 | 0.006 |
| R-HSA-6798695 | Neutrophil degranulation | 0.988055 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 0.988471 | 0.005 |
| R-HSA-1643685 | Disease | 0.996721 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.997614 | 0.001 |
| R-HSA-72766 | Translation | 0.997678 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.999429 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999518 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999827 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.820 | 0.125 | 2 | 0.868 |
CLK3 |
0.816 | 0.156 | 1 | 0.866 |
MOS |
0.804 | 0.055 | 1 | 0.850 |
MTOR |
0.804 | 0.027 | 1 | 0.799 |
FAM20C |
0.803 | 0.163 | 2 | 0.747 |
KIS |
0.803 | 0.126 | 1 | 0.806 |
CDC7 |
0.803 | -0.003 | 1 | 0.824 |
DSTYK |
0.802 | 0.086 | 2 | 0.890 |
PRPK |
0.800 | -0.042 | -1 | 0.881 |
PIM3 |
0.799 | -0.003 | -3 | 0.842 |
NLK |
0.799 | 0.076 | 1 | 0.887 |
NDR2 |
0.798 | -0.030 | -3 | 0.842 |
IKKA |
0.798 | 0.148 | -2 | 0.747 |
CAMK2G |
0.797 | 0.027 | 2 | 0.818 |
SRPK1 |
0.796 | 0.064 | -3 | 0.749 |
CDK8 |
0.796 | 0.136 | 1 | 0.789 |
IKKB |
0.796 | 0.007 | -2 | 0.761 |
RAF1 |
0.796 | 0.007 | 1 | 0.787 |
GRK1 |
0.796 | 0.122 | -2 | 0.796 |
ERK5 |
0.795 | 0.044 | 1 | 0.852 |
BMPR2 |
0.795 | -0.006 | -2 | 0.899 |
CDKL1 |
0.794 | 0.018 | -3 | 0.804 |
ATR |
0.794 | 0.002 | 1 | 0.792 |
NEK6 |
0.793 | 0.013 | -2 | 0.887 |
GCN2 |
0.793 | -0.074 | 2 | 0.770 |
PDHK4 |
0.793 | -0.130 | 1 | 0.822 |
CDK19 |
0.792 | 0.130 | 1 | 0.761 |
HIPK4 |
0.791 | 0.059 | 1 | 0.859 |
CDK1 |
0.790 | 0.149 | 1 | 0.775 |
CAMK1B |
0.790 | -0.046 | -3 | 0.863 |
GRK7 |
0.790 | 0.153 | 1 | 0.751 |
NEK7 |
0.789 | 0.010 | -3 | 0.858 |
ULK2 |
0.789 | -0.067 | 2 | 0.769 |
TBK1 |
0.789 | -0.045 | 1 | 0.675 |
GRK5 |
0.789 | -0.034 | -3 | 0.865 |
GRK6 |
0.789 | 0.057 | 1 | 0.797 |
SRPK2 |
0.788 | 0.052 | -3 | 0.677 |
SKMLCK |
0.788 | -0.004 | -2 | 0.892 |
PIM1 |
0.787 | 0.009 | -3 | 0.786 |
DYRK2 |
0.787 | 0.110 | 1 | 0.820 |
ICK |
0.787 | 0.046 | -3 | 0.838 |
BMPR1B |
0.787 | 0.106 | 1 | 0.790 |
IKKE |
0.787 | -0.037 | 1 | 0.665 |
CDKL5 |
0.786 | -0.000 | -3 | 0.791 |
JNK3 |
0.786 | 0.145 | 1 | 0.786 |
PKN3 |
0.786 | -0.033 | -3 | 0.829 |
MLK1 |
0.785 | -0.014 | 2 | 0.799 |
LATS2 |
0.785 | -0.063 | -5 | 0.096 |
CDK18 |
0.785 | 0.126 | 1 | 0.749 |
RSK2 |
0.785 | -0.019 | -3 | 0.771 |
CLK2 |
0.785 | 0.112 | -3 | 0.754 |
PRKD1 |
0.785 | -0.062 | -3 | 0.815 |
MST4 |
0.785 | -0.033 | 2 | 0.842 |
NDR1 |
0.785 | -0.073 | -3 | 0.835 |
JNK2 |
0.784 | 0.138 | 1 | 0.762 |
PDHK1 |
0.784 | -0.141 | 1 | 0.787 |
TGFBR2 |
0.784 | -0.054 | -2 | 0.805 |
NIK |
0.784 | -0.086 | -3 | 0.883 |
CDK7 |
0.784 | 0.079 | 1 | 0.803 |
CAMLCK |
0.783 | -0.031 | -2 | 0.880 |
LATS1 |
0.783 | 0.029 | -3 | 0.861 |
CDK5 |
0.783 | 0.125 | 1 | 0.813 |
PKCD |
0.782 | 0.008 | 2 | 0.791 |
ATM |
0.782 | 0.015 | 1 | 0.725 |
GRK4 |
0.782 | 0.012 | -2 | 0.844 |
DAPK2 |
0.782 | -0.044 | -3 | 0.866 |
TGFBR1 |
0.781 | 0.058 | -2 | 0.792 |
CDK13 |
0.781 | 0.100 | 1 | 0.783 |
CHAK2 |
0.781 | -0.014 | -1 | 0.839 |
WNK1 |
0.781 | -0.085 | -2 | 0.907 |
CAMK2B |
0.781 | 0.021 | 2 | 0.809 |
NUAK2 |
0.781 | -0.072 | -3 | 0.840 |
SRPK3 |
0.780 | 0.033 | -3 | 0.726 |
ACVR2B |
0.780 | 0.091 | -2 | 0.808 |
CAMK2D |
0.780 | -0.070 | -3 | 0.837 |
P90RSK |
0.780 | -0.046 | -3 | 0.776 |
HIPK2 |
0.780 | 0.121 | 1 | 0.762 |
CLK4 |
0.780 | 0.055 | -3 | 0.767 |
ULK1 |
0.780 | -0.088 | -3 | 0.839 |
CLK1 |
0.780 | 0.067 | -3 | 0.743 |
MAPKAPK2 |
0.779 | -0.033 | -3 | 0.735 |
MAPKAPK3 |
0.779 | -0.084 | -3 | 0.772 |
BCKDK |
0.778 | -0.110 | -1 | 0.833 |
P38G |
0.778 | 0.133 | 1 | 0.703 |
ERK1 |
0.778 | 0.124 | 1 | 0.764 |
RIPK3 |
0.778 | -0.108 | 3 | 0.738 |
MARK4 |
0.778 | -0.063 | 4 | 0.828 |
PRKD2 |
0.778 | -0.052 | -3 | 0.768 |
CDK17 |
0.778 | 0.118 | 1 | 0.703 |
P38B |
0.778 | 0.124 | 1 | 0.767 |
CAMK2A |
0.777 | -0.007 | 2 | 0.811 |
MLK3 |
0.777 | 0.013 | 2 | 0.741 |
P38A |
0.777 | 0.110 | 1 | 0.821 |
RSK3 |
0.777 | -0.051 | -3 | 0.766 |
P70S6KB |
0.777 | -0.048 | -3 | 0.796 |
DLK |
0.777 | -0.069 | 1 | 0.793 |
HUNK |
0.777 | -0.105 | 2 | 0.768 |
CDK3 |
0.776 | 0.131 | 1 | 0.722 |
NEK9 |
0.776 | -0.088 | 2 | 0.813 |
PLK1 |
0.776 | 0.009 | -2 | 0.835 |
ACVR2A |
0.776 | 0.060 | -2 | 0.799 |
PKN2 |
0.776 | -0.075 | -3 | 0.831 |
CDK2 |
0.775 | 0.086 | 1 | 0.820 |
ALK4 |
0.774 | -0.022 | -2 | 0.823 |
WNK3 |
0.774 | -0.139 | 1 | 0.763 |
HIPK1 |
0.774 | 0.088 | 1 | 0.833 |
ALK2 |
0.774 | 0.044 | -2 | 0.800 |
DYRK4 |
0.774 | 0.115 | 1 | 0.768 |
AURC |
0.774 | 0.001 | -2 | 0.696 |
MLK4 |
0.773 | 0.041 | 2 | 0.719 |
AMPKA1 |
0.773 | -0.105 | -3 | 0.847 |
MLK2 |
0.773 | -0.110 | 2 | 0.806 |
RSK4 |
0.773 | -0.003 | -3 | 0.745 |
MASTL |
0.773 | -0.204 | -2 | 0.831 |
PKACG |
0.773 | -0.042 | -2 | 0.776 |
CDK12 |
0.772 | 0.092 | 1 | 0.761 |
CDK16 |
0.772 | 0.120 | 1 | 0.721 |
ANKRD3 |
0.772 | -0.103 | 1 | 0.798 |
ERK2 |
0.772 | 0.095 | 1 | 0.805 |
MSK2 |
0.772 | -0.029 | -3 | 0.740 |
BMPR1A |
0.771 | 0.090 | 1 | 0.761 |
TSSK2 |
0.771 | -0.130 | -5 | 0.081 |
PKR |
0.770 | -0.034 | 1 | 0.788 |
PKACB |
0.770 | 0.017 | -2 | 0.716 |
DNAPK |
0.770 | 0.002 | 1 | 0.656 |
PRKX |
0.769 | 0.045 | -3 | 0.676 |
P38D |
0.769 | 0.140 | 1 | 0.713 |
PKCB |
0.769 | -0.030 | 2 | 0.740 |
PKCA |
0.769 | -0.026 | 2 | 0.730 |
PLK3 |
0.769 | 0.002 | 2 | 0.762 |
NIM1 |
0.769 | -0.093 | 3 | 0.771 |
SMG1 |
0.768 | -0.047 | 1 | 0.742 |
MEK1 |
0.768 | -0.084 | 2 | 0.811 |
RIPK1 |
0.768 | -0.161 | 1 | 0.770 |
CDK9 |
0.768 | 0.062 | 1 | 0.787 |
PAK1 |
0.768 | -0.042 | -2 | 0.819 |
MSK1 |
0.768 | -0.006 | -3 | 0.743 |
YSK4 |
0.767 | -0.082 | 1 | 0.725 |
CAMK4 |
0.767 | -0.121 | -3 | 0.819 |
IRE1 |
0.767 | -0.090 | 1 | 0.747 |
AMPKA2 |
0.767 | -0.096 | -3 | 0.815 |
PRP4 |
0.767 | 0.055 | -3 | 0.758 |
TLK2 |
0.767 | 0.005 | 1 | 0.735 |
PKCG |
0.767 | -0.051 | 2 | 0.732 |
TSSK1 |
0.766 | -0.100 | -3 | 0.864 |
GSK3A |
0.766 | 0.080 | 4 | 0.559 |
DYRK1A |
0.766 | 0.061 | 1 | 0.839 |
PINK1 |
0.766 | 0.020 | 1 | 0.833 |
VRK2 |
0.766 | -0.138 | 1 | 0.845 |
CDK14 |
0.766 | 0.090 | 1 | 0.779 |
GRK2 |
0.765 | 0.001 | -2 | 0.725 |
CHK1 |
0.765 | -0.112 | -3 | 0.828 |
IRE2 |
0.765 | -0.057 | 2 | 0.736 |
TTBK2 |
0.765 | -0.131 | 2 | 0.671 |
DYRK1B |
0.765 | 0.077 | 1 | 0.781 |
NUAK1 |
0.765 | -0.082 | -3 | 0.793 |
MNK2 |
0.765 | -0.071 | -2 | 0.827 |
HIPK3 |
0.765 | 0.063 | 1 | 0.824 |
CK2A2 |
0.764 | 0.104 | 1 | 0.711 |
PAK3 |
0.764 | -0.081 | -2 | 0.817 |
BRAF |
0.764 | -0.001 | -4 | 0.833 |
PKCH |
0.763 | -0.047 | 2 | 0.715 |
NEK2 |
0.763 | -0.098 | 2 | 0.789 |
PRKD3 |
0.763 | -0.072 | -3 | 0.737 |
PKCZ |
0.763 | -0.059 | 2 | 0.770 |
PIM2 |
0.763 | -0.035 | -3 | 0.743 |
QSK |
0.763 | -0.055 | 4 | 0.800 |
MYLK4 |
0.762 | -0.043 | -2 | 0.807 |
DYRK3 |
0.762 | 0.065 | 1 | 0.825 |
DRAK1 |
0.762 | -0.033 | 1 | 0.753 |
CDK10 |
0.761 | 0.076 | 1 | 0.770 |
AURB |
0.761 | -0.022 | -2 | 0.694 |
SIK |
0.761 | -0.049 | -3 | 0.764 |
AURA |
0.760 | 0.011 | -2 | 0.669 |
CHAK1 |
0.760 | -0.089 | 2 | 0.756 |
PASK |
0.760 | -0.013 | -3 | 0.854 |
JNK1 |
0.759 | 0.107 | 1 | 0.750 |
AKT2 |
0.759 | -0.016 | -3 | 0.685 |
MNK1 |
0.759 | -0.063 | -2 | 0.832 |
MELK |
0.759 | -0.114 | -3 | 0.798 |
TAO3 |
0.759 | 0.025 | 1 | 0.758 |
MEKK3 |
0.759 | -0.092 | 1 | 0.761 |
MARK2 |
0.758 | -0.043 | 4 | 0.713 |
ERK7 |
0.758 | 0.034 | 2 | 0.543 |
PHKG1 |
0.758 | -0.115 | -3 | 0.826 |
PKG2 |
0.758 | -0.037 | -2 | 0.714 |
QIK |
0.758 | -0.140 | -3 | 0.828 |
MEKK2 |
0.758 | -0.037 | 2 | 0.783 |
GSK3B |
0.758 | 0.030 | 4 | 0.551 |
MEKK1 |
0.757 | -0.056 | 1 | 0.750 |
PAK6 |
0.757 | -0.032 | -2 | 0.740 |
MARK3 |
0.757 | -0.052 | 4 | 0.753 |
MAPKAPK5 |
0.756 | -0.109 | -3 | 0.717 |
SGK3 |
0.756 | -0.044 | -3 | 0.748 |
BRSK1 |
0.756 | -0.087 | -3 | 0.790 |
PERK |
0.755 | -0.118 | -2 | 0.840 |
GAK |
0.755 | 0.017 | 1 | 0.819 |
PAK2 |
0.755 | -0.085 | -2 | 0.802 |
HRI |
0.755 | -0.140 | -2 | 0.868 |
MEK5 |
0.755 | -0.166 | 2 | 0.803 |
NEK5 |
0.755 | -0.088 | 1 | 0.776 |
MST3 |
0.754 | -0.059 | 2 | 0.817 |
CDK6 |
0.753 | 0.097 | 1 | 0.763 |
CK1E |
0.753 | -0.030 | -3 | 0.571 |
CK2A1 |
0.753 | 0.083 | 1 | 0.694 |
DCAMKL1 |
0.752 | -0.078 | -3 | 0.784 |
SMMLCK |
0.752 | -0.059 | -3 | 0.813 |
ZAK |
0.752 | -0.114 | 1 | 0.726 |
PLK4 |
0.752 | -0.084 | 2 | 0.577 |
CAMK1G |
0.752 | -0.082 | -3 | 0.764 |
TLK1 |
0.752 | -0.096 | -2 | 0.845 |
PKACA |
0.751 | -0.001 | -2 | 0.664 |
MAK |
0.751 | 0.082 | -2 | 0.747 |
MARK1 |
0.751 | -0.077 | 4 | 0.778 |
GRK3 |
0.750 | -0.006 | -2 | 0.679 |
CDK4 |
0.750 | 0.092 | 1 | 0.749 |
MPSK1 |
0.750 | -0.043 | 1 | 0.768 |
WNK4 |
0.750 | -0.135 | -2 | 0.897 |
PKCT |
0.749 | -0.061 | 2 | 0.728 |
PLK2 |
0.749 | 0.043 | -3 | 0.839 |
BRSK2 |
0.748 | -0.139 | -3 | 0.810 |
GCK |
0.748 | -0.027 | 1 | 0.755 |
NEK8 |
0.748 | -0.078 | 2 | 0.796 |
TAO2 |
0.747 | -0.062 | 2 | 0.842 |
MST2 |
0.747 | -0.018 | 1 | 0.751 |
AKT1 |
0.747 | -0.017 | -3 | 0.701 |
SNRK |
0.747 | -0.178 | 2 | 0.639 |
IRAK4 |
0.747 | -0.138 | 1 | 0.748 |
CK1D |
0.747 | -0.017 | -3 | 0.520 |
P70S6K |
0.746 | -0.082 | -3 | 0.701 |
LKB1 |
0.746 | -0.102 | -3 | 0.837 |
CAMKK1 |
0.746 | -0.091 | -2 | 0.755 |
DAPK3 |
0.746 | -0.019 | -3 | 0.802 |
TNIK |
0.744 | -0.016 | 3 | 0.856 |
NEK11 |
0.744 | -0.146 | 1 | 0.742 |
MOK |
0.744 | 0.048 | 1 | 0.834 |
DCAMKL2 |
0.743 | -0.099 | -3 | 0.809 |
CAMK1D |
0.743 | -0.067 | -3 | 0.684 |
PDK1 |
0.743 | -0.075 | 1 | 0.750 |
TAK1 |
0.742 | -0.034 | 1 | 0.770 |
PDHK3_TYR |
0.741 | 0.132 | 4 | 0.937 |
PKCI |
0.741 | -0.078 | 2 | 0.737 |
PHKG2 |
0.741 | -0.108 | -3 | 0.792 |
CK1G1 |
0.741 | -0.054 | -3 | 0.576 |
CAMKK2 |
0.741 | -0.117 | -2 | 0.746 |
HGK |
0.741 | -0.069 | 3 | 0.849 |
EEF2K |
0.741 | -0.063 | 3 | 0.826 |
PKCE |
0.741 | -0.046 | 2 | 0.717 |
MINK |
0.739 | -0.069 | 1 | 0.733 |
CK1A2 |
0.739 | -0.035 | -3 | 0.518 |
SSTK |
0.739 | -0.130 | 4 | 0.799 |
DAPK1 |
0.738 | -0.026 | -3 | 0.780 |
NEK4 |
0.738 | -0.132 | 1 | 0.733 |
HPK1 |
0.738 | -0.076 | 1 | 0.738 |
PAK5 |
0.738 | -0.054 | -2 | 0.672 |
MEKK6 |
0.737 | -0.122 | 1 | 0.755 |
BUB1 |
0.737 | -0.043 | -5 | 0.082 |
SGK1 |
0.737 | -0.017 | -3 | 0.604 |
SBK |
0.737 | -0.026 | -3 | 0.571 |
LRRK2 |
0.737 | -0.126 | 2 | 0.822 |
PDHK4_TYR |
0.736 | 0.099 | 2 | 0.873 |
VRK1 |
0.736 | -0.115 | 2 | 0.814 |
IRAK1 |
0.736 | -0.195 | -1 | 0.786 |
TTBK1 |
0.736 | -0.153 | 2 | 0.595 |
MAP3K15 |
0.736 | -0.116 | 1 | 0.718 |
KHS1 |
0.735 | -0.047 | 1 | 0.722 |
MAP2K6_TYR |
0.734 | 0.107 | -1 | 0.905 |
AKT3 |
0.734 | -0.021 | -3 | 0.621 |
PAK4 |
0.734 | -0.045 | -2 | 0.679 |
NEK1 |
0.734 | -0.120 | 1 | 0.749 |
CHK2 |
0.734 | -0.063 | -3 | 0.631 |
KHS2 |
0.733 | -0.034 | 1 | 0.740 |
SLK |
0.733 | -0.061 | -2 | 0.727 |
MST1 |
0.733 | -0.090 | 1 | 0.728 |
LOK |
0.732 | -0.105 | -2 | 0.789 |
MAP2K4_TYR |
0.732 | 0.036 | -1 | 0.901 |
MRCKB |
0.731 | -0.041 | -3 | 0.731 |
PKN1 |
0.731 | -0.082 | -3 | 0.716 |
ROCK2 |
0.731 | -0.046 | -3 | 0.780 |
ALPHAK3 |
0.731 | 0.069 | -1 | 0.785 |
MRCKA |
0.730 | -0.064 | -3 | 0.753 |
TESK1_TYR |
0.730 | -0.070 | 3 | 0.869 |
TTK |
0.730 | -0.006 | -2 | 0.846 |
CAMK1A |
0.729 | -0.071 | -3 | 0.654 |
PDHK1_TYR |
0.729 | 0.078 | -1 | 0.911 |
BMPR2_TYR |
0.729 | 0.048 | -1 | 0.895 |
PBK |
0.729 | -0.063 | 1 | 0.734 |
OSR1 |
0.729 | -0.001 | 2 | 0.776 |
YSK1 |
0.727 | -0.103 | 2 | 0.792 |
DMPK1 |
0.727 | -0.026 | -3 | 0.759 |
MEK2 |
0.725 | -0.173 | 2 | 0.775 |
MAP2K7_TYR |
0.724 | -0.109 | 2 | 0.843 |
PKMYT1_TYR |
0.724 | -0.077 | 3 | 0.829 |
PINK1_TYR |
0.724 | -0.049 | 1 | 0.820 |
STK33 |
0.723 | -0.132 | 2 | 0.585 |
RIPK2 |
0.723 | -0.187 | 1 | 0.679 |
LIMK2_TYR |
0.723 | -0.050 | -3 | 0.889 |
BIKE |
0.722 | -0.034 | 1 | 0.704 |
TXK |
0.721 | 0.102 | 1 | 0.817 |
HASPIN |
0.721 | -0.046 | -1 | 0.700 |
CRIK |
0.720 | -0.052 | -3 | 0.701 |
NEK3 |
0.718 | -0.148 | 1 | 0.713 |
ROCK1 |
0.718 | -0.049 | -3 | 0.746 |
EPHB4 |
0.718 | -0.006 | -1 | 0.864 |
PKG1 |
0.718 | -0.048 | -2 | 0.634 |
EPHA6 |
0.718 | -0.023 | -1 | 0.880 |
MYO3B |
0.718 | -0.055 | 2 | 0.807 |
LIMK1_TYR |
0.716 | -0.108 | 2 | 0.841 |
YES1 |
0.716 | 0.013 | -1 | 0.873 |
RET |
0.715 | -0.093 | 1 | 0.761 |
MYO3A |
0.715 | -0.045 | 1 | 0.724 |
ABL2 |
0.715 | 0.017 | -1 | 0.836 |
ASK1 |
0.714 | -0.123 | 1 | 0.706 |
BLK |
0.713 | 0.075 | -1 | 0.869 |
TYRO3 |
0.713 | -0.081 | 3 | 0.780 |
TAO1 |
0.713 | -0.084 | 1 | 0.676 |
CSF1R |
0.713 | -0.026 | 3 | 0.778 |
LCK |
0.712 | 0.038 | -1 | 0.863 |
TYK2 |
0.711 | -0.125 | 1 | 0.748 |
FGR |
0.711 | -0.059 | 1 | 0.813 |
CK1A |
0.711 | -0.031 | -3 | 0.434 |
MST1R |
0.711 | -0.104 | 3 | 0.788 |
ROS1 |
0.710 | -0.089 | 3 | 0.755 |
DDR1 |
0.710 | -0.110 | 4 | 0.865 |
INSRR |
0.710 | -0.018 | 3 | 0.738 |
SRMS |
0.710 | 0.002 | 1 | 0.807 |
HCK |
0.710 | -0.012 | -1 | 0.862 |
JAK2 |
0.709 | -0.097 | 1 | 0.753 |
FER |
0.709 | -0.035 | 1 | 0.825 |
ABL1 |
0.709 | -0.023 | -1 | 0.831 |
JAK3 |
0.709 | -0.062 | 1 | 0.751 |
EPHA4 |
0.708 | -0.013 | 2 | 0.766 |
ITK |
0.708 | -0.013 | -1 | 0.837 |
EPHB1 |
0.707 | -0.029 | 1 | 0.791 |
AAK1 |
0.707 | -0.018 | 1 | 0.613 |
NEK10_TYR |
0.707 | -0.042 | 1 | 0.672 |
TNK2 |
0.706 | -0.057 | 3 | 0.740 |
FYN |
0.706 | 0.059 | -1 | 0.839 |
EPHB2 |
0.705 | -0.014 | -1 | 0.849 |
YANK3 |
0.705 | -0.062 | 2 | 0.388 |
FGFR2 |
0.704 | -0.071 | 3 | 0.783 |
EPHB3 |
0.704 | -0.053 | -1 | 0.852 |
MERTK |
0.703 | -0.026 | 3 | 0.765 |
PDGFRB |
0.703 | -0.068 | 3 | 0.787 |
FLT3 |
0.703 | -0.054 | 3 | 0.778 |
KIT |
0.702 | -0.064 | 3 | 0.773 |
STLK3 |
0.702 | -0.120 | 1 | 0.694 |
BMX |
0.702 | -0.013 | -1 | 0.756 |
TEC |
0.702 | -0.015 | -1 | 0.772 |
MET |
0.701 | -0.042 | 3 | 0.767 |
KDR |
0.701 | -0.064 | 3 | 0.756 |
JAK1 |
0.701 | -0.053 | 1 | 0.691 |
AXL |
0.700 | -0.079 | 3 | 0.763 |
TNNI3K_TYR |
0.699 | -0.095 | 1 | 0.759 |
BTK |
0.698 | -0.089 | -1 | 0.801 |
FGFR1 |
0.698 | -0.098 | 3 | 0.750 |
TNK1 |
0.698 | -0.103 | 3 | 0.760 |
EPHA7 |
0.697 | -0.035 | 2 | 0.770 |
TEK |
0.697 | -0.113 | 3 | 0.716 |
LYN |
0.696 | -0.018 | 3 | 0.686 |
FLT1 |
0.696 | -0.060 | -1 | 0.843 |
WEE1_TYR |
0.695 | -0.066 | -1 | 0.768 |
FGFR3 |
0.695 | -0.062 | 3 | 0.759 |
EPHA3 |
0.694 | -0.073 | 2 | 0.738 |
NTRK1 |
0.694 | -0.087 | -1 | 0.834 |
DDR2 |
0.694 | -0.039 | 3 | 0.721 |
EPHA5 |
0.694 | -0.010 | 2 | 0.759 |
PTK6 |
0.693 | -0.089 | -1 | 0.757 |
PTK2 |
0.693 | 0.038 | -1 | 0.803 |
PTK2B |
0.692 | -0.036 | -1 | 0.813 |
FRK |
0.692 | -0.057 | -1 | 0.873 |
SRC |
0.692 | -0.007 | -1 | 0.838 |
ALK |
0.692 | -0.103 | 3 | 0.696 |
NTRK2 |
0.692 | -0.082 | 3 | 0.742 |
LTK |
0.691 | -0.091 | 3 | 0.716 |
INSR |
0.691 | -0.078 | 3 | 0.705 |
PDGFRA |
0.690 | -0.175 | 3 | 0.782 |
CK1G3 |
0.690 | -0.033 | -3 | 0.387 |
NTRK3 |
0.690 | -0.049 | -1 | 0.788 |
ERBB2 |
0.690 | -0.096 | 1 | 0.712 |
EPHA1 |
0.690 | -0.109 | 3 | 0.746 |
EPHA8 |
0.689 | -0.024 | -1 | 0.836 |
SYK |
0.689 | 0.032 | -1 | 0.791 |
MATK |
0.689 | -0.044 | -1 | 0.760 |
EGFR |
0.689 | -0.028 | 1 | 0.630 |
FLT4 |
0.688 | -0.107 | 3 | 0.739 |
CSK |
0.685 | -0.065 | 2 | 0.759 |
FGFR4 |
0.683 | -0.024 | -1 | 0.789 |
EPHA2 |
0.679 | -0.040 | -1 | 0.795 |
ERBB4 |
0.677 | -0.026 | 1 | 0.651 |
IGF1R |
0.675 | -0.074 | 3 | 0.641 |
CK1G2 |
0.674 | -0.032 | -3 | 0.488 |
YANK2 |
0.672 | -0.077 | 2 | 0.409 |
MUSK |
0.672 | -0.113 | 1 | 0.616 |
ZAP70 |
0.666 | -0.020 | -1 | 0.720 |
FES |
0.662 | -0.082 | -1 | 0.733 |