Motif 160 (n=220)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1W2PNV4 | None | S502 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| A0A1W2PPC1 | PRR33 | S207 | ochoa | Proline rich 33 | None |
| A6NNC1 | None | S202 | ochoa | Putative POM121-like protein 1-like | None |
| A8MQ03 | CYSRT1 | S93 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| A8MZF0 | PRR33 | S59 | ochoa | Proline-rich protein 33 | None |
| O00192 | ARVCF | S203 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O14686 | KMT2D | S1722 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O15020 | SPTBN2 | S2199 | ochoa | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | Probably plays an important role in neuronal membrane skeleton. |
| O15056 | SYNJ2 | S1434 | ochoa | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| O15143 | ARPC1B | S170 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O15357 | INPPL1 | S149 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15417 | TNRC18 | S611 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43432 | EIF4G3 | S164 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43900 | PRICKLE3 | S437 | ochoa | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. |
| O60216 | RAD21 | S459 | ochoa | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:Q61550, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:11509732, ECO:0000269|PubMed:11590136, ECO:0000269|PubMed:25575569, ECO:0000305|PubMed:25575569}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000269|PubMed:11875078, ECO:0000269|PubMed:12417729}. |
| O60883 | GPR37L1 | S462 | ochoa | G-protein coupled receptor 37-like 1 (Endothelin B receptor-like protein 2) (ETBR-LP-2) | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). {ECO:0000250|UniProtKB:Q99JG2, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:27072655, ECO:0000269|PubMed:28688853}. |
| O75044 | SRGAP2 | S1027 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75112 | LDB3 | S505 | ochoa | LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) | May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}. |
| O75208 | COQ9 | S59 | ochoa | Ubiquinone biosynthesis protein COQ9, mitochondrial | Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (PubMed:25339443, PubMed:30661980, PubMed:38425362). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443, PubMed:30661980). {ECO:0000269|PubMed:25339443, ECO:0000269|PubMed:30661980, ECO:0000269|PubMed:38425362}. |
| O75369 | FLNB | S1523 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O94885 | SASH1 | S478 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O94966 | USP19 | S897 | ochoa | Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) | Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:19465887, PubMed:24356957). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:24356957). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination (PubMed:21849505). Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1 (PubMed:22128162, PubMed:33978709). Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (PubMed:38943386). Negatively regulates TNF-alpha- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (PubMed:33094816). {ECO:0000250|UniProtKB:Q3UJD6, ECO:0000250|UniProtKB:Q6J1Y9, ECO:0000269|PubMed:19465887, ECO:0000269|PubMed:21849505, ECO:0000269|PubMed:22128162, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:24356957, ECO:0000269|PubMed:31127032, ECO:0000269|PubMed:33094816, ECO:0000269|PubMed:33978709, ECO:0000269|PubMed:38943386}. |
| O95155 | UBE4B | S52 | ochoa | Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}. |
| O95359 | TACC2 | S1283 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95613 | PCNT | S2433 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95644 | NFATC1 | S269 | psp | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:10358178}. |
| O96028 | NSD2 | S102 | ochoa|psp | Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) | Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro (PubMed:22099308). Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3) (PubMed:22099308). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells (By similarity). By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes (PubMed:16115125, PubMed:22099308, PubMed:29728617). In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation (By similarity). During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes (By similarity). Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation (PubMed:29728617). During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation (By similarity). During B-cell development, required for the generation of the B1 lineage (By similarity). During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response (By similarity). Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation (By similarity). By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA (By similarity). {ECO:0000250|UniProtKB:Q8BVE8, ECO:0000269|PubMed:16115125, ECO:0000269|PubMed:19808676, ECO:0000269|PubMed:22099308, ECO:0000269|PubMed:27571355, ECO:0000269|PubMed:29728617, ECO:0000269|PubMed:33941880}.; FUNCTION: [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:22099308}.; FUNCTION: [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:22099308). Methylation of histone H3 at 'Lys-27' is controversial (PubMed:18172012, PubMed:22099308). Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3) (PubMed:18172012). Does not methylate histone H3 at 'Lys-27' (PubMed:22099308). May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment (PubMed:11152655, PubMed:18172012). {ECO:0000269|PubMed:11152655, ECO:0000269|PubMed:18172012, ECO:0000269|PubMed:22099308}. |
| P00966 | ASS1 | S134 | ochoa | Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}. |
| P02452 | COL1A1 | S176 | ochoa | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| P13196 | ALAS1 | S82 | ochoa | 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1) | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. {ECO:0000269|PubMed:16234850, ECO:0000269|PubMed:17975826}. |
| P13639 | EEF2 | S422 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P15291 | B4GALT1 | S73 | ochoa | Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] | [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:34855475}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269|PubMed:16157350}. |
| P15291 | B4GALT1 | S74 | ochoa | Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] | [Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:34855475}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269|PubMed:16157350}. |
| P15336 | ATF2 | S127 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P17947 | SPI1 | S112 | ochoa | Transcription factor PU.1 (31 kDa-transforming protein) | Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}. |
| P19235 | EPOR | Y485 | psp | Erythropoietin receptor (EPO-R) | Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:10388848, PubMed:2163695, PubMed:2163696, PubMed:8662939, PubMed:9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed:11756159). May also activate the LYN tyrosine kinase (By similarity). {ECO:0000250|UniProtKB:P14753, ECO:0000269|PubMed:10388848, ECO:0000269|PubMed:11756159, ECO:0000269|PubMed:2163695, ECO:0000269|PubMed:2163696, ECO:0000269|PubMed:8662939, ECO:0000269|PubMed:9774108}.; FUNCTION: [Isoform EPOR-T]: Acts as a dominant-negative receptor of EPOR-mediated signaling. {ECO:0000269|PubMed:1324524}. |
| P19971 | TYMP | S19 | ochoa | Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) | May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}. |
| P21333 | FLNA | S1551 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P25054 | APC | S2302 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
| P25490 | YY1 | S252 | ochoa | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P26651 | ZFP36 | S60 | ochoa|psp | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269|PubMed:14679154}. |
| P27694 | RPA1 | S172 | ochoa | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:17596542, PubMed:27723717, PubMed:27723720). Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Also plays a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. Plays a role in telomere maintenance (PubMed:17959650, PubMed:34767620). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105). RPA stimulates 5'-3' helicase activity of the BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:19996105, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:34767620, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P27816 | MAP4 | S742 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P27987 | ITPKB | S447 | ochoa | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}. |
| P32927 | CSF2RB | S667 | ochoa | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| P40222 | TXLNA | S499 | ochoa | Alpha-taxilin | May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. |
| P43243 | MATR3 | S276 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
| P47974 | ZFP36L2 | S57 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P47974 | ZFP36L2 | S465 | ochoa | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2) | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250|UniProtKB:P23949, ECO:0000269|PubMed:14981510, ECO:0000269|PubMed:20506496, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:34611029}. |
| P48634 | PRRC2A | S932 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48730 | CSNK1D | S331 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49023 | PXN | S219 | ochoa | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269|PubMed:25015296}. |
| P49815 | TSC2 | S1152 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P49815 | TSC2 | S1427 | ochoa | Tuberin (Tuberous sclerosis 2 protein) | Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). {ECO:0000250|UniProtKB:P49816, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12820960, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:33436626, ECO:0000269|PubMed:35772404}. |
| P50548 | ERF | S194 | ochoa | ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2) | Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). {ECO:0000250}. |
| P52209 | PGD | S129 | ochoa | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}. |
| P52272 | HNRNPM | S29 | ochoa | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) | Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. |
| P54819 | AK2 | S148 | ochoa | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:19043416}. |
| P55055 | NR1H2 | S25 | ochoa | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). {ECO:0000250|UniProtKB:Q60644, ECO:0000269|PubMed:20159957, ECO:0000269|PubMed:25661920}. |
| P55196 | AFDN | S512 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55201 | BRPF1 | S917 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P56747 | CLDN6 | S201 | ochoa | Claudin-6 (Skullin) | Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:0000269|PubMed:20375010}. |
| P78310 | CXADR | S323 | ochoa | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.; FUNCTION: (Microbial infection) Acts as a receptor for adenovirus type C. {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:9733828}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. {ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:14978041}. |
| Q03164 | KMT2A | S1114 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q03164 | KMT2A | S2319 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05209 | PTPN12 | S323 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| Q05707 | COL14A1 | S1648 | ochoa | Collagen alpha-1(XIV) chain (Undulin) | Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:2187872}. |
| Q07666 | KHDRBS1 | S24 | ochoa | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q08211 | DHX9 | S321 | ochoa | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A) | Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:24990949, PubMed:25062910, PubMed:28221134, PubMed:9111062, PubMed:37467750). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935, PubMed:21561811, PubMed:24049074). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:10198287, PubMed:9111062). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, PubMed:11149922, PubMed:11416126, PubMed:15355351, PubMed:28221134, PubMed:9323138, PubMed:9662397). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134, PubMed:28355180). In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034, PubMed:16680162, PubMed:28221134, PubMed:28355180). As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:10924507, PubMed:11402034, PubMed:9162007). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis (PubMed:28636595). Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588). {ECO:0000250|UniProtKB:O70133, ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:11038348, ECO:0000269|PubMed:11149922, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11416126, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:12711669, ECO:0000269|PubMed:15355351, ECO:0000269|PubMed:1537828, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20669935, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:21561811, ECO:0000269|PubMed:22190748, ECO:0000269|PubMed:24049074, ECO:0000269|PubMed:24990949, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:28355180, ECO:0000269|PubMed:28636595, ECO:0000269|PubMed:37467750, ECO:0000269|PubMed:9111062, ECO:0000269|PubMed:9162007, ECO:0000269|PubMed:9323138, ECO:0000269|PubMed:9662397}.; FUNCTION: (Microbial infection) Plays a role in HIV-1 replication and virion infectivity (PubMed:11096080, PubMed:19229320, PubMed:25149208, PubMed:27107641). Enhances HIV-1 transcription by facilitating the binding of RNA polymerase II holoenzyme to the proviral DNA (PubMed:11096080, PubMed:25149208). Binds (via DRBM domain 2) to the HIV-1 TAR RNA and stimulates HIV-1 transcription of transactivation response element (TAR)-containing mRNAs (PubMed:11096080, PubMed:9892698). Involved also in HIV-1 mRNA splicing and transport (PubMed:25149208). Positively regulates HIV-1 gag mRNA translation, through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Binds (via DRBM domains) to a HIV-1 double-stranded RNA region of the primer binding site (PBS)-segment of the 5'-UTR, and hence stimulates DHX9 incorporation into virions and virion infectivity (PubMed:27107641). Also plays a role as a cytosolic viral MyD88-dependent DNA and RNA sensors in plasmacytoid dendritic cells (pDCs), and hence induce antiviral innate immune responses (PubMed:20696886, PubMed:21957149). Binds (via the OB-fold region) to viral single-stranded DNA unmethylated C-phosphate-G (CpG) oligonucleotide (PubMed:20696886). {ECO:0000269|PubMed:11096080, ECO:0000269|PubMed:16680162, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:21957149, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:27107641, ECO:0000269|PubMed:9892698}. |
| Q12770 | SCAP | S838 | ochoa | Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) | Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:26311497). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (PubMed:26311497). Binds cholesterol via its SSD domain (By similarity). {ECO:0000250|UniProtKB:P97260, ECO:0000269|PubMed:26311497}. |
| Q12802 | AKAP13 | S864 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12948 | FOXC1 | S264 | ochoa | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:15299087, PubMed:15684392, PubMed:16449236, PubMed:16492674, PubMed:17210863, PubMed:19279310, PubMed:19793056, PubMed:25786029, PubMed:27804176, PubMed:27907090). Acts either as a transcriptional activator or repressor (PubMed:11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176, PubMed:7957066). Upon DNA-binding, promotes DNA bending (PubMed:14506133, PubMed:7957066). Acts as a transcriptional coactivator (PubMed:26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity). May function as a tumor suppressor (PubMed:12408963). {ECO:0000250|UniProtKB:Q61572, ECO:0000269|PubMed:11782474, ECO:0000269|PubMed:12408963, ECO:0000269|PubMed:12533514, ECO:0000269|PubMed:14506133, ECO:0000269|PubMed:14578375, ECO:0000269|PubMed:15277473, ECO:0000269|PubMed:15299087, ECO:0000269|PubMed:15684392, ECO:0000269|PubMed:16449236, ECO:0000269|PubMed:16492674, ECO:0000269|PubMed:17210863, ECO:0000269|PubMed:17993506, ECO:0000269|PubMed:19279310, ECO:0000269|PubMed:19793056, ECO:0000269|PubMed:20406990, ECO:0000269|PubMed:22991501, ECO:0000269|PubMed:25786029, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:27804176, ECO:0000269|PubMed:27907090, ECO:0000269|PubMed:7957066}. |
| Q13177 | PAK2 | S141 | ochoa|psp | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13428 | TCOF1 | S1199 | ochoa|psp | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13469 | NFATC2 | S255 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1) | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses. {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}. |
| Q13546 | RIPK1 | S262 | psp | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13554 | CAMK2B | S417 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q14004 | CDK13 | S1474 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14315 | FLNC | S1545 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14684 | RRP1B | S453 | ochoa | Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250|UniProtKB:Q91YK2, ECO:0000269|PubMed:19710015, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269|PubMed:26311876}. |
| Q14847 | LASP1 | S151 | ochoa | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}. |
| Q14978 | NOLC1 | S388 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q15569 | TESK1 | S603 | ochoa | Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}. |
| Q15599 | NHERF2 | S167 | ochoa | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus. {ECO:0000269|PubMed:10455146, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:9096337}. |
| Q15906 | VPS72 | S244 | ochoa | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. {ECO:0000269|PubMed:26974126}. |
| Q15942 | ZYX | S246 | ochoa | Zyxin (Zyxin-2) | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}. |
| Q2M3G4 | SHROOM1 | S166 | ochoa | Protein Shroom1 (Apical protein 2) | May be involved in the assembly of microtubule arrays during cell elongation. {ECO:0000250}. |
| Q4KMQ1 | TPRN | S258 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q4VC44 | FLYWCH1 | S192 | ochoa | FLYWCH-type zinc finger-containing protein 1 | Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMed:33924684). Binds specifically to DNA sequences at peri-centromeric chromatin loci. {ECO:0000269|PubMed:30097457, ECO:0000269|PubMed:33924684, ECO:0000269|PubMed:34408139}. |
| Q4VCS5 | AMOT | S229 | ochoa | Angiomotin | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21205866}. |
| Q5SV97 | PERM1 | S166 | ochoa | PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1) | Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. {ECO:0000250|UniProtKB:Q149B8}. |
| Q5T6C5 | ATXN7L2 | S478 | ochoa | Ataxin-7-like protein 2 | None |
| Q5T9C2 | EEIG1 | S186 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5TZA2 | CROCC | S483 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VST9 | OBSCN | S7023 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VST9 | OBSCN | S7395 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT06 | CEP350 | S930 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q63ZY3 | KANK2 | S155 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q641Q2 | WASHC2A | S1144 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q66K74 | MAP1S | S929 | ochoa | Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity). {ECO:0000250, ECO:0000269|PubMed:15899810, ECO:0000269|PubMed:17234756}. |
| Q68CZ2 | TNS3 | S361 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68CZ2 | TNS3 | S602 | ochoa | Tensin-3 (EC 3.1.3.-) (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex (PubMed:17643115). EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1 (PubMed:17643115). Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA (PubMed:26166433). Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration (PubMed:35687021). Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1 (PubMed:31905841). {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}. |
| Q68EM7 | ARHGAP17 | S610 | ochoa | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}. |
| Q6AI12 | ANKRD40 | S214 | ochoa | Ankyrin repeat domain-containing protein 40 | None |
| Q6NSZ9 | ZSCAN25 | S300 | ochoa | Zinc finger and SCAN domain-containing protein 25 (Zinc finger protein 498) | May be involved in transcriptional regulation. {ECO:0000250}. |
| Q6NZ67 | MZT2B | S139 | ochoa | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6P0Q8 | MAST2 | S281 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6P2E9 | EDC4 | S771 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P582 | MZT2A | S139 | ochoa | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:39321809}. |
| Q6P5Z2 | PKN3 | S488 | ochoa | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Q6UWF3 | SCIMP | S90 | ochoa | SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) | Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}. |
| Q6UXY1 | BAIAP2L2 | S227 | ochoa | BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) | Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}. |
| Q6ZRV2 | FAM83H | S936 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | S1048 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZUT6 | CCDC9B | S210 | ochoa | Coiled-coil domain-containing protein 9B | None |
| Q6ZW31 | SYDE1 | Y229 | ochoa | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). {ECO:0000269|PubMed:27917469}. |
| Q70EL1 | USP54 | S1588 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q7Z2Z1 | TICRR | S1613 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z6I6 | ARHGAP30 | S240 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86UW9 | DTX2 | S236 | ochoa | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Q86VP3 | PACS2 | S700 | ochoa | Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:15692567}. |
| Q86X29 | LSR | S436 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q86YV0 | RASAL3 | S236 | ochoa | RAS protein activator like-3 | Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}. |
| Q8IV48 | ERI1 | S21 | ochoa | 3'-5' exoribonuclease 1 (EC 3.1.13.1) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication (PubMed:14536070, PubMed:16912046, PubMed:17135487, PubMed:37352860). A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates (PubMed:14536070, PubMed:16912046, PubMed:17135487). Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) (PubMed:14961122). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure (PubMed:14536070, PubMed:16912046). Able to bind other mRNAs (PubMed:14536070, PubMed:16912046). Required for 5.8S rRNA 3'-end processing (PubMed:37352860). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs (PubMed:14536070, PubMed:16912046, PubMed:17135487). In vitro, does not have sequence specificity (PubMed:17135487). In vitro, has weak DNA exonuclease activity (PubMed:17135487). In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours (PubMed:17135487). ERI1-mediated RNA metabolism plays a key role in chondrogenesis (PubMed:37352860). {ECO:0000250|UniProtKB:Q7TMF2, ECO:0000269|PubMed:14536070, ECO:0000269|PubMed:14961122, ECO:0000269|PubMed:16912046, ECO:0000269|PubMed:17135487, ECO:0000269|PubMed:37352860}. |
| Q8IVT2 | MISP | S156 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8IX15 | HOMEZ | S315 | ochoa | Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor) | May function as a transcriptional regulator. |
| Q8IYJ3 | SYTL1 | S216 | ochoa | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Q8N3V7 | SYNPO | S289 | ochoa | Synaptopodin | Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). {ECO:0000250}. |
| Q8N6T3 | ARFGAP1 | S378 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NC96 | NECAP1 | S202 | ochoa | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | Involved in endocytosis. {ECO:0000250}. |
| Q8NF91 | SYNE1 | S5917 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NHW3 | MAFA | S49 | psp | Transcription factor MafA (Pancreatic beta-cell-specific transcriptional activator) (RIPE3b1 factor) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) | Transcription factor that activates insulin gene expression (PubMed:12011435, PubMed:15993959). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498). {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:23148532, ECO:0000269|PubMed:29339498}. |
| Q8NI35 | PATJ | S333 | ochoa | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}. |
| Q8TER5 | ARHGEF40 | S988 | ochoa | Rho guanine nucleotide exchange factor 40 (Protein SOLO) | May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}. |
| Q8WUA7 | TBC1D22A | S21 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WUF5 | PPP1R13L | S151 | ochoa | RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein) | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900, ECO:0000269|PubMed:28069640}. |
| Q8WV41 | SNX33 | S146 | ochoa | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Q8WWM7 | ATXN2L | S98 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WWM7 | ATXN2L | S615 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q8WXE0 | CASKIN2 | S705 | ochoa | Caskin-2 (CASK-interacting protein 2) | None |
| Q8WZ74 | CTTNBP2 | S361 | ochoa | Cortactin-binding protein 2 (CortBP2) | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. {ECO:0000250|UniProtKB:Q2IBD4}. |
| Q92738 | USP6NL | S633 | ochoa | USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre) | Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269|PubMed:11099046, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057}. |
| Q92835 | INPP5D | S951 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:10764818, PubMed:8769125, PubMed:9108392). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269|PubMed:10764818, ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172, ECO:0000269|PubMed:8723348, ECO:0000269|PubMed:8769125, ECO:0000269|PubMed:9108392}. |
| Q92870 | APBB2 | S330 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q92945 | KHSRP | Y688 | psp | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q96AE4 | FUBP1 | Y625 | ochoa|psp | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269|PubMed:8125259}. |
| Q96AP7 | ESAM | S312 | ochoa | Endothelial cell-selective adhesion molecule | Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250|UniProtKB:Q925F2}. |
| Q96E39 | RBMXL1 | S184 | ochoa | RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) | RNA-binding protein which may be involved in pre-mRNA splicing. {ECO:0000250}. |
| Q96EV2 | RBM33 | S997 | ochoa | RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) | RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451). {ECO:0000269|PubMed:35589130, ECO:0000269|PubMed:37257451}. |
| Q96G42 | KLHDC7B | S517 | ochoa | Kelch domain-containing protein 7B | None |
| Q96JK9 | MAML3 | S613 | ochoa | Mastermind-like protein 3 (Mam-3) | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. {ECO:0000269|PubMed:12370315, ECO:0000269|PubMed:12386158}. |
| Q96JQ0 | DCHS1 | S2983 | ochoa | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302). {ECO:0000269|PubMed:26258302}. |
| Q96JT2 | SLC45A3 | S423 | ochoa | Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) | Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}. |
| Q96KS0 | EGLN2 | S234 | psp | Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) | Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}. |
| Q96PE2 | ARHGEF17 | S509 | ochoa | Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269|PubMed:12071859}. |
| Q96QT4 | TRPM7 | S1567 | ochoa|psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RF0 | SNX18 | S202 | ochoa | Sorting nexin-18 (SH3 and PX domain-containing protein 3B) | Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}. |
| Q96S21 | RAB40C | S256 | ochoa | Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}. |
| Q9BQG0 | MYBBP1A | S1207 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BTC0 | DIDO1 | S1650 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX63 | BRIP1 | S197 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BY89 | KIAA1671 | S1608 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYB0 | SHANK3 | S375 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9BZ72 | PITPNM2 | S867 | ochoa | Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269|PubMed:10022914}. |
| Q9C0K0 | BCL11B | S257 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H0F6 | SHARPIN | S131 | ochoa|psp | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}. |
| Q9H201 | EPN3 | S370 | ochoa | Epsin-3 (EPS-15-interacting protein 3) | None |
| Q9H2E6 | SEMA6A | S994 | ochoa | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. {ECO:0000250|UniProtKB:O35464}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H2F5 | EPC1 | S348 | ochoa | Enhancer of polycomb homolog 1 | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}. |
| Q9H3T3 | SEMA6B | S749 | ochoa | Semaphorin-6B (Semaphorin-Z) (Sema Z) | Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269|PubMed:32302524, ECO:0000269|PubMed:32589945}. |
| Q9H4E7 | DEF6 | S606 | ochoa | Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein) | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). {ECO:0000250|UniProtKB:Q8C2K1, ECO:0000269|PubMed:12651066, ECO:0000269|PubMed:15023524, ECO:0000269|PubMed:31308374}. |
| Q9H4I2 | ZHX3 | S599 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H5H4 | ZNF768 | S116 | ochoa | Zinc finger protein 768 | Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable). {ECO:0000269|PubMed:30476274, ECO:0000269|PubMed:34404770, ECO:0000305}. |
| Q9H5N1 | RABEP2 | S189 | ochoa | Rab GTPase-binding effector protein 2 (Rabaptin-5beta) | Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062). {ECO:0000269|PubMed:27224062, ECO:0000269|PubMed:29425100, ECO:0000269|PubMed:9524116}. |
| Q9H987 | SYNPO2L | S427 | ochoa | Synaptopodin 2-like protein | Actin-associated protein that may play a role in modulating actin-based shape. {ECO:0000250}. |
| Q9HAU0 | PLEKHA5 | S382 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HAW4 | CLSPN | S774 | ochoa | Claspin (hClaspin) | Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:27401717, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| Q9HC35 | EML4 | S888 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9HCJ0 | TNRC6C | S714 | ochoa | Trinucleotide repeat-containing gene 6C protein | Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}. |
| Q9HCK8 | CHD8 | S2202 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9HCU4 | CELSR2 | S2678 | ochoa | Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) | Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Q9NWH9 | SLTM | S962 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWV8 | BABAM1 | S66 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9P206 | NHSL3 | S832 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P227 | ARHGAP23 | S316 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P266 | JCAD | S915 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P270 | SLAIN2 | S435 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
| Q9P2F8 | SIPA1L2 | S1552 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9P2J2 | IGSF9 | S813 | ochoa | Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A) | Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}. |
| Q9UBL3 | ASH2L | S321 | ochoa | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q9UBP9 | GULP1 | S229 | ochoa | PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}. |
| Q9UDY2 | TJP2 | S979 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UF83 | None | S317 | ochoa | Uncharacterized protein DKFZp434B061 | None |
| Q9UHY1 | NRBP1 | S363 | ochoa | Nuclear receptor-binding protein | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). {ECO:0000250|UniProtKB:Q99J45, ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397}. |
| Q9UID3 | VPS51 | S652 | ochoa | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). {ECO:0000269|PubMed:20685960, ECO:0000269|PubMed:25799061}. |
| Q9ULD5 | ZNF777 | S625 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9ULX9 | MAFF | S146 | ochoa | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846). {ECO:0000269|PubMed:10527846, ECO:0000269|PubMed:16549056, ECO:0000269|PubMed:8932385}. |
| Q9UN86 | G3BP2 | S286 | ochoa | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). {ECO:0000250|UniProtKB:Q13283, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:35977029}. |
| Q9Y2H0 | DLGAP4 | S768 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y2R2 | PTPN22 | S684 | ochoa | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}. |
| Q9Y2W2 | WBP11 | S181 | ochoa | WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1) | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}. |
| Q9Y2X7 | GIT1 | S508 | ochoa|psp | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through PAK1 activation, positively regulates microtubule nucleation during interphase (PubMed:27012601). Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (PubMed:23108400). May promote cell motility both by regulating focal complex dynamics and by local activation of RAC1 (PubMed:10938112, PubMed:11896197). May act as scaffold for MAPK1/3 signal transduction in focal adhesions. Recruits MAPK1/3/ERK1/2 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12695502). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (By similarity). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (By similarity). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing (By similarity). The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (PubMed:31502302). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (PubMed:19273721). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000250|UniProtKB:Q9Z272, ECO:0000269|PubMed:10938112, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:15800193, ECO:0000269|PubMed:15923189, ECO:0000269|PubMed:19273721, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:25284783, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:31502302}. |
| Q9Y6I3 | EPN1 | S447 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6I3 | EPN1 | S486 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| Q9Y6K5 | OAS3 | S385 | ochoa | 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). {ECO:0000269|PubMed:19056102, ECO:0000269|PubMed:19923450, ECO:0000269|PubMed:9880533}. |
| Q9Y6R4 | MAP3K4 | S420 | ochoa | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. |
| Q9Y6X6 | MYO16 | S1341 | ochoa | Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}. |
| O75821 | EIF3G | S217 | Sugiyama | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
| P26640 | VARS1 | S613 | Sugiyama | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P26885 | FKBP2 | S108 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Q02750 | MAP2K1 | S252 | SIGNOR | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. {ECO:0000269|PubMed:14737111, ECO:0000269|PubMed:17101779, ECO:0000269|PubMed:29433126}. |
| P31939 | ATIC | S202 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P35368 | ADRA1B | S412 | SIGNOR|iPTMNet|EPSD | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P31150 | GDI1 | S213 | Sugiyama | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4) | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. {ECO:0000269|PubMed:23815289}. |
| P50395 | GDI2 | S213 | Sugiyama | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| Q13470 | TNK1 | S354 | Sugiyama | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:18974114}. |
| Q96GD4 | AURKB | S19 | Sugiyama | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| O43175 | PHGDH | S166 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| Q9NRA0 | SPHK2 | S393 | Sugiyama | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) | Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9JIA7, ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:16118219, ECO:0000269|PubMed:19168031, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20959514}. |
| P35658 | NUP214 | S421 | Sugiyama | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.000010 | 4.999 |
| R-HSA-2025928 | Calcineurin activates NFAT | 0.000758 | 3.120 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.002484 | 2.605 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.002484 | 2.605 |
| R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 0.002400 | 2.620 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 0.004778 | 2.321 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.004063 | 2.391 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.005116 | 2.291 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.005504 | 2.259 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 0.006182 | 2.209 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 0.008937 | 2.049 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.008750 | 2.058 |
| R-HSA-75153 | Apoptotic execution phase | 0.008248 | 2.084 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.010035 | 1.998 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.010035 | 1.998 |
| R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.014366 | 1.843 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.028526 | 1.545 |
| R-HSA-4793953 | Defective B4GALT1 causes CDG-2d | 0.042483 | 1.372 |
| R-HSA-9845622 | Defective VWF binding to collagen type I | 0.042483 | 1.372 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.056241 | 1.250 |
| R-HSA-9845621 | Defective VWF cleavage by ADAMTS13 variant | 0.056241 | 1.250 |
| R-HSA-9845619 | Enhanced cleavage of VWF variant by ADAMTS13 | 0.056241 | 1.250 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 0.083169 | 1.080 |
| R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.083169 | 1.080 |
| R-HSA-9652169 | Signaling by MAP2K mutants | 0.083169 | 1.080 |
| R-HSA-9846298 | Defective binding of VWF variant to GPIb:IX:V | 0.096345 | 1.016 |
| R-HSA-9845620 | Enhanced binding of GP1BA variant to VWF multimer:collagen | 0.096345 | 1.016 |
| R-HSA-9823587 | Defects of platelet adhesion to exposed collagen | 0.109332 | 0.961 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 0.109332 | 0.961 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 0.109332 | 0.961 |
| R-HSA-3656244 | Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | 0.122133 | 0.913 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 0.122133 | 0.913 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 0.134751 | 0.870 |
| R-HSA-9031525 | NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake | 0.134751 | 0.870 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.134751 | 0.870 |
| R-HSA-9031528 | NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipo... | 0.134751 | 0.870 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.147189 | 0.832 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.159448 | 0.797 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.159448 | 0.797 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.159448 | 0.797 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.055157 | 1.258 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.171532 | 0.766 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 0.171532 | 0.766 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 0.171532 | 0.766 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.183443 | 0.736 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.183443 | 0.736 |
| R-HSA-4839744 | Signaling by APC mutants | 0.183443 | 0.736 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.183443 | 0.736 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.183443 | 0.736 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.183443 | 0.736 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.195184 | 0.710 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 0.195184 | 0.710 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.195184 | 0.710 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.195184 | 0.710 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 0.206756 | 0.685 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 0.206756 | 0.685 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.206756 | 0.685 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.206756 | 0.685 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.083297 | 1.079 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.218163 | 0.661 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.091995 | 1.036 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.096440 | 1.016 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.100945 | 0.996 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.100945 | 0.996 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.240489 | 0.619 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.240489 | 0.619 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.240489 | 0.619 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.240489 | 0.619 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.240489 | 0.619 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.110123 | 0.958 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.110123 | 0.958 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.114792 | 0.940 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.251412 | 0.600 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.251412 | 0.600 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.031010 | 1.509 |
| R-HSA-1221632 | Meiotic synapsis | 0.059685 | 1.224 |
| R-HSA-380287 | Centrosome maturation | 0.033448 | 1.476 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.124278 | 0.906 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.262180 | 0.581 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.143772 | 0.842 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.283253 | 0.548 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.148742 | 0.828 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.293565 | 0.532 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.293565 | 0.532 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.053577 | 1.271 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.303728 | 0.518 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.303728 | 0.518 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.303728 | 0.518 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.303728 | 0.518 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.303728 | 0.518 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.303728 | 0.518 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.323620 | 0.490 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.323620 | 0.490 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.323620 | 0.490 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.342946 | 0.465 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.221087 | 0.655 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.247649 | 0.606 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.274314 | 0.562 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.274314 | 0.562 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.284975 | 0.545 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.290300 | 0.537 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.348368 | 0.458 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.313746 | 0.503 |
| R-HSA-2243919 | Crosslinking of collagen fibrils | 0.293565 | 0.532 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.023701 | 1.625 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.240489 | 0.619 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.013393 | 1.873 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 0.031439 | 1.503 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.037695 | 1.424 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.206756 | 0.685 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.218163 | 0.661 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.229406 | 0.639 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.272793 | 0.564 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.293565 | 0.532 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.333353 | 0.477 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.327393 | 0.485 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.206756 | 0.685 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.158784 | 0.799 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.184386 | 0.734 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.184386 | 0.734 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.184386 | 0.734 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.184386 | 0.734 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.096345 | 1.016 |
| R-HSA-5653890 | Lactose synthesis | 0.122133 | 0.913 |
| R-HSA-420029 | Tight junction interactions | 0.074871 | 1.126 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.229406 | 0.639 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.110123 | 0.958 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.110123 | 0.958 |
| R-HSA-75893 | TNF signaling | 0.237003 | 0.625 |
| R-HSA-3928664 | Ephrin signaling | 0.044383 | 1.353 |
| R-HSA-1500620 | Meiosis | 0.047280 | 1.325 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.036807 | 1.434 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 0.083169 | 1.080 |
| R-HSA-68877 | Mitotic Prometaphase | 0.035984 | 1.444 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.037468 | 1.426 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.236790 | 0.626 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.236790 | 0.626 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.252979 | 0.597 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.153747 | 0.813 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.086240 | 1.064 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.123755 | 0.907 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.251412 | 0.600 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.119511 | 0.923 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.184386 | 0.734 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.295621 | 0.529 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.252979 | 0.597 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.343143 | 0.465 |
| R-HSA-5693538 | Homology Directed Repair | 0.044188 | 1.355 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.056241 | 1.250 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.069802 | 1.156 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.013393 | 1.873 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.147189 | 0.832 |
| R-HSA-2534343 | Interaction With Cumulus Cells And The Zona Pellucida | 0.159448 | 0.797 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 0.171532 | 0.766 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.195184 | 0.710 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.195184 | 0.710 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.195184 | 0.710 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.240489 | 0.619 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.119511 | 0.923 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.133944 | 0.873 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.179216 | 0.747 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.323620 | 0.490 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.333353 | 0.477 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.202966 | 0.693 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.283253 | 0.548 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.104336 | 0.982 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 0.134751 | 0.870 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.295621 | 0.529 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.300936 | 0.522 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 0.096345 | 1.016 |
| R-HSA-3295583 | TRP channels | 0.079048 | 1.102 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.240489 | 0.619 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.316837 | 0.499 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.110997 | 0.955 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.159448 | 0.797 |
| R-HSA-9761174 | Formation of intermediate mesoderm | 0.171532 | 0.766 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.114792 | 0.940 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.138839 | 0.857 |
| R-HSA-69481 | G2/M Checkpoints | 0.056898 | 1.245 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.124278 | 0.906 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.025386 | 1.595 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.271500 | 0.566 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.019578 | 1.708 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.109332 | 0.961 |
| R-HSA-8964046 | VLDL clearance | 0.134751 | 0.870 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.147189 | 0.832 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.159448 | 0.797 |
| R-HSA-1483226 | Synthesis of PI | 0.183443 | 0.736 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.262180 | 0.581 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.283253 | 0.548 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.333353 | 0.477 |
| R-HSA-191859 | snRNP Assembly | 0.252979 | 0.597 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.252979 | 0.597 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.263645 | 0.579 |
| R-HSA-73887 | Death Receptor Signaling | 0.040383 | 1.394 |
| R-HSA-182971 | EGFR downregulation | 0.100945 | 0.996 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.221087 | 0.655 |
| R-HSA-170968 | Frs2-mediated activation | 0.218163 | 0.661 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.194790 | 0.710 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.189578 | 0.722 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.159448 | 0.797 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 0.206756 | 0.685 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.119511 | 0.923 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.124278 | 0.906 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.044383 | 1.353 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.313746 | 0.503 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.248281 | 0.605 |
| R-HSA-199991 | Membrane Trafficking | 0.108694 | 0.964 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.149677 | 0.825 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.287111 | 0.542 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.057383 | 1.241 |
| R-HSA-68886 | M Phase | 0.133140 | 0.876 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.082280 | 1.085 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.248281 | 0.605 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 0.083169 | 1.080 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.020343 | 1.692 |
| R-HSA-1462054 | Alpha-defensins | 0.147189 | 0.832 |
| R-HSA-390696 | Adrenoceptors | 0.147189 | 0.832 |
| R-HSA-428540 | Activation of RAC1 | 0.195184 | 0.710 |
| R-HSA-2214320 | Anchoring fibril formation | 0.195184 | 0.710 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 0.206756 | 0.685 |
| R-HSA-9945266 | Differentiation of T cells | 0.251412 | 0.600 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.251412 | 0.600 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.251412 | 0.600 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.032215 | 1.492 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.262180 | 0.581 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.148742 | 0.828 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.148742 | 0.828 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.153747 | 0.813 |
| R-HSA-1474165 | Reproduction | 0.062513 | 1.204 |
| R-HSA-194138 | Signaling by VEGF | 0.330311 | 0.481 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.222671 | 0.652 |
| R-HSA-2028269 | Signaling by Hippo | 0.040987 | 1.387 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.171532 | 0.766 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.068460 | 1.165 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.272793 | 0.564 |
| R-HSA-9671793 | Diseases of hemostasis | 0.293565 | 0.532 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.119511 | 0.923 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.133944 | 0.873 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.283205 | 0.548 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.019515 | 1.710 |
| R-HSA-169893 | Prolonged ERK activation events | 0.251412 | 0.600 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.217045 | 0.663 |
| R-HSA-8983711 | OAS antiviral response | 0.022930 | 1.640 |
| R-HSA-164944 | Nef and signal transduction | 0.122133 | 0.913 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.134751 | 0.870 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.240489 | 0.619 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.272793 | 0.564 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.138839 | 0.857 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.313746 | 0.503 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.184386 | 0.734 |
| R-HSA-3214847 | HATs acetylate histones | 0.077002 | 1.113 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.252979 | 0.597 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.322120 | 0.492 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.033448 | 1.476 |
| R-HSA-5357801 | Programmed Cell Death | 0.228406 | 0.641 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.272793 | 0.564 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.287111 | 0.542 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.217996 | 0.662 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.091995 | 1.036 |
| R-HSA-5358508 | Mismatch Repair | 0.283253 | 0.548 |
| R-HSA-449836 | Other interleukin signaling | 0.293565 | 0.532 |
| R-HSA-1442490 | Collagen degradation | 0.263645 | 0.579 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.037695 | 1.424 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.019578 | 1.708 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.218163 | 0.661 |
| R-HSA-975577 | N-Glycan antennae elongation | 0.251412 | 0.600 |
| R-HSA-8875878 | MET promotes cell motility | 0.138839 | 0.857 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.143772 | 0.842 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.290300 | 0.537 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.182625 | 0.738 |
| R-HSA-1640170 | Cell Cycle | 0.037352 | 1.428 |
| R-HSA-162582 | Signal Transduction | 0.060981 | 1.215 |
| R-HSA-177929 | Signaling by EGFR | 0.066848 | 1.175 |
| R-HSA-195721 | Signaling by WNT | 0.313761 | 0.503 |
| R-HSA-5688426 | Deubiquitination | 0.210231 | 0.677 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.035377 | 1.451 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.242324 | 0.616 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.247649 | 0.606 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.110123 | 0.958 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.153078 | 0.815 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.218163 | 0.661 |
| R-HSA-4086398 | Ca2+ pathway | 0.327393 | 0.485 |
| R-HSA-69275 | G2/M Transition | 0.177987 | 0.750 |
| R-HSA-9675135 | Diseases of DNA repair | 0.184386 | 0.734 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.182827 | 0.738 |
| R-HSA-210990 | PECAM1 interactions | 0.183443 | 0.736 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.014568 | 1.837 |
| R-HSA-8854214 | TBC/RABGAPs | 0.168947 | 0.772 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.184706 | 0.734 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.268980 | 0.570 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.225398 | 0.647 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.104975 | 0.979 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.224483 | 0.649 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.232800 | 0.633 |
| R-HSA-3371556 | Cellular response to heat stress | 0.133782 | 0.874 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.104975 | 0.979 |
| R-HSA-4839726 | Chromatin organization | 0.017414 | 1.759 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.217990 | 0.662 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.274314 | 0.562 |
| R-HSA-8848021 | Signaling by PTK6 | 0.274314 | 0.562 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.032902 | 1.483 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.206756 | 0.685 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 0.229406 | 0.639 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 0.293565 | 0.532 |
| R-HSA-977347 | Serine metabolism | 0.323620 | 0.490 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.259856 | 0.585 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.159951 | 0.796 |
| R-HSA-186712 | Regulation of beta-cell development | 0.252979 | 0.597 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.259856 | 0.585 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.240610 | 0.619 |
| R-HSA-109581 | Apoptosis | 0.122096 | 0.913 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.206756 | 0.685 |
| R-HSA-416700 | Other semaphorin interactions | 0.240489 | 0.619 |
| R-HSA-8876725 | Protein methylation | 0.240489 | 0.619 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.262180 | 0.581 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.043021 | 1.366 |
| R-HSA-446728 | Cell junction organization | 0.012310 | 1.910 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.322444 | 0.492 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.177530 | 0.751 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.147189 | 0.832 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.147189 | 0.832 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.171532 | 0.766 |
| R-HSA-9842663 | Signaling by LTK | 0.206756 | 0.685 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.218163 | 0.661 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.013364 | 1.874 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.335368 | 0.474 |
| R-HSA-373755 | Semaphorin interactions | 0.274314 | 0.562 |
| R-HSA-1500931 | Cell-Cell communication | 0.025688 | 1.590 |
| R-HSA-202403 | TCR signaling | 0.259856 | 0.585 |
| R-HSA-913531 | Interferon Signaling | 0.134549 | 0.871 |
| R-HSA-450294 | MAP kinase activation | 0.263645 | 0.579 |
| R-HSA-449147 | Signaling by Interleukins | 0.228353 | 0.641 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.044383 | 1.353 |
| R-HSA-180292 | GAB1 signalosome | 0.283253 | 0.548 |
| R-HSA-445144 | Signal transduction by L1 | 0.303728 | 0.518 |
| R-HSA-212436 | Generic Transcription Pathway | 0.266546 | 0.574 |
| R-HSA-448424 | Interleukin-17 signaling | 0.311545 | 0.506 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.087613 | 1.057 |
| R-HSA-5673000 | RAF activation | 0.119511 | 0.923 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.143772 | 0.842 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.118033 | 0.928 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.018300 | 1.738 |
| R-HSA-1483255 | PI Metabolism | 0.083032 | 1.081 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.115390 | 0.938 |
| R-HSA-211000 | Gene Silencing by RNA | 0.248281 | 0.605 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.169666 | 0.770 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.096440 | 1.016 |
| R-HSA-8948216 | Collagen chain trimerization | 0.133944 | 0.873 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.333353 | 0.477 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.342946 | 0.465 |
| R-HSA-3000170 | Syndecan interactions | 0.342946 | 0.465 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.129089 | 0.889 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.312741 | 0.505 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.031010 | 1.509 |
| R-HSA-189200 | Cellular hexose transport | 0.333353 | 0.477 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.342946 | 0.465 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 0.272793 | 0.564 |
| R-HSA-8964038 | LDL clearance | 0.333353 | 0.477 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.342946 | 0.465 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.202966 | 0.693 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.296444 | 0.528 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.215800 | 0.666 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.284975 | 0.545 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.077002 | 1.113 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.343143 | 0.465 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.352402 | 0.453 |
| R-HSA-429947 | Deadenylation of mRNA | 0.352402 | 0.453 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 0.352402 | 0.453 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.352402 | 0.453 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.353579 | 0.452 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.353579 | 0.452 |
| R-HSA-421270 | Cell-cell junction organization | 0.355635 | 0.449 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.361723 | 0.442 |
| R-HSA-9620244 | Long-term potentiation | 0.361723 | 0.442 |
| R-HSA-9839394 | TGFBR3 expression | 0.361723 | 0.442 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.361723 | 0.442 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.361723 | 0.442 |
| R-HSA-1187000 | Fertilization | 0.361723 | 0.442 |
| R-HSA-9909396 | Circadian clock | 0.361727 | 0.442 |
| R-HSA-6806834 | Signaling by MET | 0.363956 | 0.439 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.370909 | 0.431 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.370909 | 0.431 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 0.370909 | 0.431 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.370909 | 0.431 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.370909 | 0.431 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.370909 | 0.431 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.370909 | 0.431 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.370909 | 0.431 |
| R-HSA-70635 | Urea cycle | 0.370909 | 0.431 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.372783 | 0.429 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.374270 | 0.427 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.379965 | 0.420 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.379965 | 0.420 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.379965 | 0.420 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.379965 | 0.420 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.379965 | 0.420 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.384516 | 0.415 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.384516 | 0.415 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.388890 | 0.410 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.388890 | 0.410 |
| R-HSA-73614 | Pyrimidine salvage | 0.388890 | 0.410 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.389613 | 0.409 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.389613 | 0.409 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.390781 | 0.408 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.392919 | 0.406 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.394690 | 0.404 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.397687 | 0.400 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.397687 | 0.400 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.397687 | 0.400 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 0.397687 | 0.400 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.397687 | 0.400 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.399748 | 0.398 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.400520 | 0.397 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.404786 | 0.393 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.404786 | 0.393 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.406359 | 0.391 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.406359 | 0.391 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.406359 | 0.391 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.406359 | 0.391 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.406359 | 0.391 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.406359 | 0.391 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.408376 | 0.389 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.414906 | 0.382 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.414906 | 0.382 |
| R-HSA-168256 | Immune System | 0.418318 | 0.378 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.419779 | 0.377 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.423330 | 0.373 |
| R-HSA-69190 | DNA strand elongation | 0.423330 | 0.373 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.424734 | 0.372 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.429667 | 0.367 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.431334 | 0.365 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.431429 | 0.365 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.431634 | 0.365 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.431634 | 0.365 |
| R-HSA-2022854 | Keratan sulfate biosynthesis | 0.431634 | 0.365 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.431634 | 0.365 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.431634 | 0.365 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.431634 | 0.365 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.431634 | 0.365 |
| R-HSA-422475 | Axon guidance | 0.434368 | 0.362 |
| R-HSA-74160 | Gene expression (Transcription) | 0.434472 | 0.362 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.434577 | 0.362 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.435235 | 0.361 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.438917 | 0.358 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.439818 | 0.357 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.439818 | 0.357 |
| R-HSA-1474290 | Collagen formation | 0.444330 | 0.352 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.446462 | 0.350 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.447886 | 0.349 |
| R-HSA-1980145 | Signaling by NOTCH2 | 0.447886 | 0.349 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.453967 | 0.343 |
| R-HSA-169911 | Regulation of Apoptosis | 0.455837 | 0.341 |
| R-HSA-187687 | Signalling to ERKs | 0.455837 | 0.341 |
| R-HSA-381042 | PERK regulates gene expression | 0.455837 | 0.341 |
| R-HSA-1989781 | PPARA activates gene expression | 0.457703 | 0.339 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.458784 | 0.338 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.463256 | 0.334 |
| R-HSA-114604 | GPVI-mediated activation cascade | 0.463675 | 0.334 |
| R-HSA-3371511 | HSF1 activation | 0.463675 | 0.334 |
| R-HSA-111933 | Calmodulin induced events | 0.463675 | 0.334 |
| R-HSA-111997 | CaM pathway | 0.463675 | 0.334 |
| R-HSA-8853659 | RET signaling | 0.463675 | 0.334 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.465144 | 0.332 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.468298 | 0.329 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.468298 | 0.329 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.468298 | 0.329 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.468848 | 0.329 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.471400 | 0.327 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 0.471400 | 0.327 |
| R-HSA-73894 | DNA Repair | 0.471818 | 0.326 |
| R-HSA-877300 | Interferon gamma signaling | 0.472540 | 0.326 |
| R-HSA-70171 | Glycolysis | 0.477712 | 0.321 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.479014 | 0.320 |
| R-HSA-1483257 | Phospholipid metabolism | 0.479878 | 0.319 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.482632 | 0.316 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.483288 | 0.316 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.486519 | 0.313 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.486519 | 0.313 |
| R-HSA-71336 | Pentose phosphate pathway | 0.486519 | 0.313 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 0.486519 | 0.313 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.487025 | 0.312 |
| R-HSA-9646399 | Aggrephagy | 0.493917 | 0.306 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.493917 | 0.306 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 0.493917 | 0.306 |
| R-HSA-202433 | Generation of second messenger molecules | 0.493917 | 0.306 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.496234 | 0.304 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.501208 | 0.300 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.501208 | 0.300 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.501208 | 0.300 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.501208 | 0.300 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.501208 | 0.300 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.505338 | 0.296 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.508395 | 0.294 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.508395 | 0.294 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.508395 | 0.294 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.508395 | 0.294 |
| R-HSA-189451 | Heme biosynthesis | 0.508395 | 0.294 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.508395 | 0.294 |
| R-HSA-9675108 | Nervous system development | 0.509479 | 0.293 |
| R-HSA-8939211 | ESR-mediated signaling | 0.510930 | 0.292 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.510930 | 0.292 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.515478 | 0.288 |
| R-HSA-165159 | MTOR signalling | 0.515478 | 0.288 |
| R-HSA-111996 | Ca-dependent events | 0.515478 | 0.288 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.515478 | 0.288 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.518792 | 0.285 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.518792 | 0.285 |
| R-HSA-157118 | Signaling by NOTCH | 0.519996 | 0.284 |
| R-HSA-1461973 | Defensins | 0.522460 | 0.282 |
| R-HSA-73621 | Pyrimidine catabolism | 0.522460 | 0.282 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.522933 | 0.282 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.523223 | 0.281 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.523223 | 0.281 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.526433 | 0.279 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.529342 | 0.276 |
| R-HSA-5683826 | Surfactant metabolism | 0.529342 | 0.276 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.529342 | 0.276 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.529342 | 0.276 |
| R-HSA-6803157 | Antimicrobial peptides | 0.532003 | 0.274 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.536125 | 0.271 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 0.536125 | 0.271 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.536125 | 0.271 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.536125 | 0.271 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.540672 | 0.267 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.542811 | 0.265 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.542811 | 0.265 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.553466 | 0.257 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.553466 | 0.257 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.554823 | 0.256 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.555896 | 0.255 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.555896 | 0.255 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.555896 | 0.255 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.557675 | 0.254 |
| R-HSA-373760 | L1CAM interactions | 0.561856 | 0.250 |
| R-HSA-73893 | DNA Damage Bypass | 0.562298 | 0.250 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.562298 | 0.250 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 0.562298 | 0.250 |
| R-HSA-70326 | Glucose metabolism | 0.566008 | 0.247 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.566949 | 0.246 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.568608 | 0.245 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.574228 | 0.241 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.574228 | 0.241 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.574228 | 0.241 |
| R-HSA-912446 | Meiotic recombination | 0.574827 | 0.240 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.574827 | 0.240 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.574827 | 0.240 |
| R-HSA-68875 | Mitotic Prophase | 0.578296 | 0.238 |
| R-HSA-983712 | Ion channel transport | 0.580429 | 0.236 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.580957 | 0.236 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.580957 | 0.236 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.582335 | 0.235 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.582335 | 0.235 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.586346 | 0.232 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.586346 | 0.232 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.586902 | 0.231 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.587000 | 0.231 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.587000 | 0.231 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.587000 | 0.231 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.590328 | 0.229 |
| R-HSA-72649 | Translation initiation complex formation | 0.592955 | 0.227 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.596492 | 0.224 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.598825 | 0.223 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.602105 | 0.220 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.602105 | 0.220 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.602105 | 0.220 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.604610 | 0.219 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.604610 | 0.219 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.604610 | 0.219 |
| R-HSA-5578775 | Ion homeostasis | 0.604610 | 0.219 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.610313 | 0.214 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.613625 | 0.212 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.615234 | 0.211 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.615934 | 0.210 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.615934 | 0.210 |
| R-HSA-180786 | Extension of Telomeres | 0.621473 | 0.207 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.624384 | 0.205 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.626934 | 0.203 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.626934 | 0.203 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.626934 | 0.203 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.626934 | 0.203 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.626934 | 0.203 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.626934 | 0.203 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.626934 | 0.203 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.626934 | 0.203 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.626934 | 0.203 |
| R-HSA-379724 | tRNA Aminoacylation | 0.626934 | 0.203 |
| R-HSA-72172 | mRNA Splicing | 0.630402 | 0.200 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.632258 | 0.199 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.632258 | 0.199 |
| R-HSA-112043 | PLC beta mediated events | 0.632316 | 0.199 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.632316 | 0.199 |
| R-HSA-8956321 | Nucleotide salvage | 0.632316 | 0.199 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.637620 | 0.195 |
| R-HSA-9707616 | Heme signaling | 0.637620 | 0.195 |
| R-HSA-186797 | Signaling by PDGF | 0.637620 | 0.195 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.648002 | 0.188 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.650185 | 0.187 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.651813 | 0.186 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.653081 | 0.185 |
| R-HSA-397014 | Muscle contraction | 0.653804 | 0.185 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.656653 | 0.183 |
| R-HSA-6807070 | PTEN Regulation | 0.660606 | 0.180 |
| R-HSA-112040 | G-protein mediated events | 0.663022 | 0.178 |
| R-HSA-9830369 | Kidney development | 0.663022 | 0.178 |
| R-HSA-68882 | Mitotic Anaphase | 0.665102 | 0.177 |
| R-HSA-1632852 | Macroautophagy | 0.667415 | 0.176 |
| R-HSA-5218859 | Regulated Necrosis | 0.667885 | 0.175 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.667885 | 0.175 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.667885 | 0.175 |
| R-HSA-418990 | Adherens junctions interactions | 0.670651 | 0.174 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.672679 | 0.172 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.674113 | 0.171 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.677403 | 0.169 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.677403 | 0.169 |
| R-HSA-3000178 | ECM proteoglycans | 0.682060 | 0.166 |
| R-HSA-8978934 | Metabolism of cofactors | 0.682060 | 0.166 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.682060 | 0.166 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.682060 | 0.166 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.682060 | 0.166 |
| R-HSA-189445 | Metabolism of porphyrins | 0.682060 | 0.166 |
| R-HSA-1280218 | Adaptive Immune System | 0.684997 | 0.164 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.686650 | 0.163 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.686650 | 0.163 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.686650 | 0.163 |
| R-HSA-69242 | S Phase | 0.693554 | 0.159 |
| R-HSA-166520 | Signaling by NTRKs | 0.693554 | 0.159 |
| R-HSA-162906 | HIV Infection | 0.694789 | 0.158 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.695632 | 0.158 |
| R-HSA-9758941 | Gastrulation | 0.696700 | 0.157 |
| R-HSA-8953854 | Metabolism of RNA | 0.698270 | 0.156 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.699969 | 0.155 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.700027 | 0.155 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.700027 | 0.155 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.702912 | 0.153 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.704358 | 0.152 |
| R-HSA-5689603 | UCH proteinases | 0.704358 | 0.152 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.712835 | 0.147 |
| R-HSA-216083 | Integrin cell surface interactions | 0.712835 | 0.147 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.715020 | 0.146 |
| R-HSA-9659379 | Sensory processing of sound | 0.716983 | 0.144 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.716983 | 0.144 |
| R-HSA-15869 | Metabolism of nucleotides | 0.717574 | 0.144 |
| R-HSA-9612973 | Autophagy | 0.717982 | 0.144 |
| R-HSA-9610379 | HCMV Late Events | 0.720918 | 0.142 |
| R-HSA-162587 | HIV Life Cycle | 0.720918 | 0.142 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.721070 | 0.142 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.721070 | 0.142 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.721070 | 0.142 |
| R-HSA-9833482 | PKR-mediated signaling | 0.721070 | 0.142 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.740757 | 0.130 |
| R-HSA-2262752 | Cellular responses to stress | 0.743514 | 0.129 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.744391 | 0.128 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.744391 | 0.128 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.748084 | 0.126 |
| R-HSA-5619102 | SLC transporter disorders | 0.748886 | 0.126 |
| R-HSA-156902 | Peptide chain elongation | 0.755312 | 0.122 |
| R-HSA-9663891 | Selective autophagy | 0.755312 | 0.122 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.755312 | 0.122 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.759384 | 0.120 |
| R-HSA-72306 | tRNA processing | 0.759384 | 0.120 |
| R-HSA-73884 | Base Excision Repair | 0.762334 | 0.118 |
| R-HSA-202424 | Downstream TCR signaling | 0.762334 | 0.118 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.769965 | 0.114 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.770027 | 0.113 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.772492 | 0.112 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.779022 | 0.108 |
| R-HSA-168255 | Influenza Infection | 0.781629 | 0.107 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.782217 | 0.107 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.782698 | 0.106 |
| R-HSA-2559583 | Cellular Senescence | 0.783987 | 0.106 |
| R-HSA-1266738 | Developmental Biology | 0.784075 | 0.106 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.785366 | 0.105 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.788470 | 0.103 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.791529 | 0.102 |
| R-HSA-157579 | Telomere Maintenance | 0.791529 | 0.102 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.794544 | 0.100 |
| R-HSA-190236 | Signaling by FGFR | 0.794544 | 0.100 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.800444 | 0.097 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.802057 | 0.096 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.803330 | 0.095 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.806175 | 0.094 |
| R-HSA-5617833 | Cilium Assembly | 0.806361 | 0.093 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.808979 | 0.092 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.811743 | 0.091 |
| R-HSA-111885 | Opioid Signalling | 0.811743 | 0.091 |
| R-HSA-9609690 | HCMV Early Events | 0.818778 | 0.087 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.818778 | 0.087 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.819797 | 0.086 |
| R-HSA-69239 | Synthesis of DNA | 0.822404 | 0.085 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.824975 | 0.084 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.824975 | 0.084 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.827508 | 0.082 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.827508 | 0.082 |
| R-HSA-168249 | Innate Immune System | 0.829380 | 0.081 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.834890 | 0.078 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.835566 | 0.078 |
| R-HSA-112316 | Neuronal System | 0.837954 | 0.077 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.848724 | 0.071 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.848724 | 0.071 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.850184 | 0.070 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.853074 | 0.069 |
| R-HSA-73886 | Chromosome Maintenance | 0.859366 | 0.066 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.863411 | 0.064 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.867829 | 0.062 |
| R-HSA-69206 | G1/S Transition | 0.869263 | 0.061 |
| R-HSA-114608 | Platelet degranulation | 0.873024 | 0.059 |
| R-HSA-8956319 | Nucleotide catabolism | 0.876678 | 0.057 |
| R-HSA-72312 | rRNA processing | 0.880763 | 0.055 |
| R-HSA-5576891 | Cardiac conduction | 0.881964 | 0.055 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.885361 | 0.053 |
| R-HSA-72766 | Translation | 0.892295 | 0.049 |
| R-HSA-5368287 | Mitochondrial translation | 0.894981 | 0.048 |
| R-HSA-597592 | Post-translational protein modification | 0.896850 | 0.047 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.898005 | 0.047 |
| R-HSA-9664407 | Parasite infection | 0.898005 | 0.047 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.898005 | 0.047 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.899485 | 0.046 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.899809 | 0.046 |
| R-HSA-9609646 | HCMV Infection | 0.903263 | 0.044 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.907924 | 0.042 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.913154 | 0.039 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.913154 | 0.039 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.915379 | 0.038 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.915657 | 0.038 |
| R-HSA-69306 | DNA Replication | 0.916882 | 0.038 |
| R-HSA-6798695 | Neutrophil degranulation | 0.916958 | 0.038 |
| R-HSA-9679506 | SARS-CoV Infections | 0.921735 | 0.035 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.921761 | 0.035 |
| R-HSA-9711097 | Cellular response to starvation | 0.922744 | 0.035 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.924971 | 0.034 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.927151 | 0.033 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.938874 | 0.027 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.938874 | 0.027 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.939762 | 0.027 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.940638 | 0.027 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.940638 | 0.027 |
| R-HSA-388396 | GPCR downstream signalling | 0.944253 | 0.025 |
| R-HSA-3781865 | Diseases of glycosylation | 0.947971 | 0.023 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.949474 | 0.023 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.953728 | 0.021 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 0.954401 | 0.020 |
| R-HSA-428157 | Sphingolipid metabolism | 0.959449 | 0.018 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.959768 | 0.018 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.960622 | 0.017 |
| R-HSA-1474244 | Extracellular matrix organization | 0.963545 | 0.016 |
| R-HSA-372790 | Signaling by GPCR | 0.972462 | 0.012 |
| R-HSA-109582 | Hemostasis | 0.977241 | 0.010 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.982814 | 0.008 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.983666 | 0.007 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.983937 | 0.007 |
| R-HSA-416476 | G alpha (q) signalling events | 0.984172 | 0.007 |
| R-HSA-418594 | G alpha (i) signalling events | 0.986162 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 0.986976 | 0.006 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.987680 | 0.005 |
| R-HSA-9658195 | Leishmania infection | 0.987680 | 0.005 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.987860 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 0.989296 | 0.005 |
| R-HSA-8957322 | Metabolism of steroids | 0.993470 | 0.003 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.996388 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.996809 | 0.001 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.997315 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997819 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998742 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.998881 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999151 | 0.000 |
| R-HSA-9824446 | Viral Infection Pathways | 0.999348 | 0.000 |
| R-HSA-1643685 | Disease | 0.999422 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999955 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
COT |
0.870 | 0.185 | 2 | 0.877 |
PIM3 |
0.870 | 0.271 | -3 | 0.863 |
CLK3 |
0.868 | 0.266 | 1 | 0.771 |
NDR2 |
0.868 | 0.237 | -3 | 0.861 |
PRKD1 |
0.865 | 0.286 | -3 | 0.849 |
SRPK1 |
0.864 | 0.277 | -3 | 0.797 |
HIPK4 |
0.864 | 0.276 | 1 | 0.735 |
CDC7 |
0.862 | 0.090 | 1 | 0.812 |
RSK2 |
0.862 | 0.241 | -3 | 0.814 |
MOS |
0.860 | 0.167 | 1 | 0.834 |
CDKL5 |
0.860 | 0.251 | -3 | 0.822 |
P90RSK |
0.859 | 0.232 | -3 | 0.819 |
SKMLCK |
0.859 | 0.241 | -2 | 0.885 |
PRKD2 |
0.859 | 0.239 | -3 | 0.820 |
CDKL1 |
0.857 | 0.220 | -3 | 0.822 |
MTOR |
0.857 | 0.073 | 1 | 0.784 |
NDR1 |
0.857 | 0.175 | -3 | 0.851 |
TBK1 |
0.857 | 0.121 | 1 | 0.775 |
PIM1 |
0.856 | 0.242 | -3 | 0.822 |
PRPK |
0.856 | 0.026 | -1 | 0.870 |
NLK |
0.855 | 0.118 | 1 | 0.797 |
RSK3 |
0.855 | 0.203 | -3 | 0.807 |
IKKB |
0.855 | 0.029 | -2 | 0.752 |
AURC |
0.855 | 0.192 | -2 | 0.669 |
SRPK2 |
0.854 | 0.248 | -3 | 0.731 |
ERK5 |
0.854 | 0.134 | 1 | 0.802 |
RAF1 |
0.853 | 0.075 | 1 | 0.848 |
CAMK1B |
0.853 | 0.129 | -3 | 0.850 |
NUAK2 |
0.853 | 0.167 | -3 | 0.856 |
MAPKAPK2 |
0.853 | 0.196 | -3 | 0.790 |
MAPKAPK3 |
0.852 | 0.182 | -3 | 0.813 |
LATS2 |
0.852 | 0.145 | -5 | 0.785 |
ICK |
0.852 | 0.225 | -3 | 0.852 |
AMPKA1 |
0.852 | 0.188 | -3 | 0.860 |
KIS |
0.852 | 0.108 | 1 | 0.658 |
WNK1 |
0.851 | 0.133 | -2 | 0.902 |
IKKE |
0.851 | 0.080 | 1 | 0.775 |
MST4 |
0.851 | 0.154 | 2 | 0.870 |
PKN3 |
0.851 | 0.134 | -3 | 0.842 |
ATR |
0.850 | 0.084 | 1 | 0.821 |
MARK4 |
0.850 | 0.157 | 4 | 0.837 |
GCN2 |
0.850 | -0.081 | 2 | 0.828 |
AMPKA2 |
0.849 | 0.200 | -3 | 0.842 |
SRPK3 |
0.849 | 0.234 | -3 | 0.758 |
DYRK2 |
0.849 | 0.171 | 1 | 0.664 |
CAMK2D |
0.848 | 0.132 | -3 | 0.830 |
PKCD |
0.848 | 0.183 | 2 | 0.815 |
PKACG |
0.848 | 0.148 | -2 | 0.747 |
RSK4 |
0.848 | 0.230 | -3 | 0.801 |
NIK |
0.848 | 0.148 | -3 | 0.851 |
ULK2 |
0.848 | -0.052 | 2 | 0.819 |
CAMLCK |
0.847 | 0.129 | -2 | 0.864 |
PKN2 |
0.847 | 0.137 | -3 | 0.832 |
GRK1 |
0.846 | 0.126 | -2 | 0.799 |
DAPK2 |
0.846 | 0.157 | -3 | 0.851 |
TGFBR2 |
0.846 | 0.038 | -2 | 0.783 |
RIPK3 |
0.846 | 0.019 | 3 | 0.685 |
PDHK4 |
0.846 | -0.156 | 1 | 0.842 |
PKACB |
0.846 | 0.205 | -2 | 0.684 |
CLK2 |
0.846 | 0.264 | -3 | 0.805 |
BMPR2 |
0.846 | -0.063 | -2 | 0.887 |
TSSK1 |
0.846 | 0.186 | -3 | 0.880 |
P70S6KB |
0.845 | 0.143 | -3 | 0.816 |
NEK6 |
0.845 | 0.029 | -2 | 0.869 |
CHAK2 |
0.845 | 0.056 | -1 | 0.827 |
DSTYK |
0.845 | -0.041 | 2 | 0.891 |
IKKA |
0.845 | 0.045 | -2 | 0.746 |
HIPK2 |
0.844 | 0.196 | 1 | 0.572 |
PDHK1 |
0.843 | -0.066 | 1 | 0.845 |
BCKDK |
0.843 | -0.011 | -1 | 0.792 |
LATS1 |
0.842 | 0.231 | -3 | 0.873 |
PKCA |
0.842 | 0.191 | 2 | 0.765 |
NIM1 |
0.842 | 0.087 | 3 | 0.717 |
QSK |
0.842 | 0.183 | 4 | 0.820 |
MNK2 |
0.842 | 0.132 | -2 | 0.804 |
PAK1 |
0.841 | 0.109 | -2 | 0.804 |
HIPK1 |
0.841 | 0.203 | 1 | 0.675 |
CLK1 |
0.840 | 0.194 | -3 | 0.783 |
PKCB |
0.840 | 0.147 | 2 | 0.771 |
TSSK2 |
0.840 | 0.109 | -5 | 0.851 |
AKT2 |
0.840 | 0.213 | -3 | 0.744 |
MNK1 |
0.840 | 0.153 | -2 | 0.810 |
MSK2 |
0.840 | 0.122 | -3 | 0.779 |
CLK4 |
0.839 | 0.171 | -3 | 0.803 |
SGK3 |
0.839 | 0.207 | -3 | 0.800 |
PRKD3 |
0.839 | 0.167 | -3 | 0.779 |
GRK5 |
0.839 | -0.108 | -3 | 0.790 |
CAMK2A |
0.839 | 0.125 | 2 | 0.779 |
CAMK2G |
0.839 | -0.121 | 2 | 0.802 |
MSK1 |
0.839 | 0.159 | -3 | 0.787 |
MLK1 |
0.839 | -0.046 | 2 | 0.841 |
PKG2 |
0.838 | 0.161 | -2 | 0.682 |
HUNK |
0.838 | -0.067 | 2 | 0.827 |
PIM2 |
0.838 | 0.222 | -3 | 0.786 |
PKCG |
0.838 | 0.134 | 2 | 0.768 |
MELK |
0.838 | 0.131 | -3 | 0.823 |
CDK7 |
0.838 | 0.058 | 1 | 0.642 |
CDK18 |
0.838 | 0.115 | 1 | 0.571 |
CDK8 |
0.838 | 0.044 | 1 | 0.630 |
CDK19 |
0.838 | 0.067 | 1 | 0.596 |
PAK3 |
0.838 | 0.076 | -2 | 0.798 |
AURB |
0.838 | 0.129 | -2 | 0.665 |
CAMK2B |
0.838 | 0.093 | 2 | 0.758 |
MLK2 |
0.838 | 0.051 | 2 | 0.847 |
PRKX |
0.838 | 0.198 | -3 | 0.751 |
PHKG1 |
0.837 | 0.105 | -3 | 0.835 |
MASTL |
0.837 | -0.095 | -2 | 0.824 |
NEK7 |
0.837 | -0.122 | -3 | 0.764 |
WNK3 |
0.837 | -0.092 | 1 | 0.805 |
NEK9 |
0.837 | -0.020 | 2 | 0.869 |
NUAK1 |
0.837 | 0.111 | -3 | 0.816 |
SIK |
0.837 | 0.161 | -3 | 0.783 |
CDK5 |
0.836 | 0.108 | 1 | 0.657 |
IRE1 |
0.836 | 0.034 | 1 | 0.744 |
JNK2 |
0.835 | 0.105 | 1 | 0.596 |
GRK7 |
0.835 | 0.105 | 1 | 0.747 |
DYRK1A |
0.834 | 0.173 | 1 | 0.691 |
CAMK4 |
0.834 | 0.016 | -3 | 0.819 |
ULK1 |
0.833 | -0.158 | -3 | 0.750 |
PAK6 |
0.833 | 0.123 | -2 | 0.716 |
BRSK1 |
0.833 | 0.099 | -3 | 0.816 |
DLK |
0.833 | -0.093 | 1 | 0.806 |
GRK6 |
0.832 | -0.077 | 1 | 0.810 |
QIK |
0.832 | 0.055 | -3 | 0.813 |
MLK3 |
0.832 | 0.034 | 2 | 0.773 |
P38A |
0.832 | 0.098 | 1 | 0.682 |
MARK3 |
0.832 | 0.142 | 4 | 0.784 |
CDK13 |
0.832 | 0.048 | 1 | 0.614 |
HIPK3 |
0.832 | 0.161 | 1 | 0.686 |
PKCZ |
0.831 | 0.090 | 2 | 0.818 |
DCAMKL1 |
0.831 | 0.162 | -3 | 0.826 |
RIPK1 |
0.831 | -0.102 | 1 | 0.769 |
BMPR1B |
0.831 | 0.048 | 1 | 0.762 |
BRSK2 |
0.831 | 0.072 | -3 | 0.819 |
TTBK2 |
0.831 | -0.093 | 2 | 0.742 |
IRE2 |
0.831 | 0.043 | 2 | 0.789 |
MYLK4 |
0.831 | 0.097 | -2 | 0.786 |
PKR |
0.830 | 0.088 | 1 | 0.801 |
AURA |
0.830 | 0.094 | -2 | 0.642 |
JNK3 |
0.830 | 0.068 | 1 | 0.621 |
PKACA |
0.830 | 0.172 | -2 | 0.631 |
ANKRD3 |
0.830 | -0.081 | 1 | 0.831 |
PKCH |
0.830 | 0.089 | 2 | 0.761 |
DYRK4 |
0.830 | 0.128 | 1 | 0.590 |
P38B |
0.829 | 0.097 | 1 | 0.619 |
YSK4 |
0.829 | 0.037 | 1 | 0.786 |
CDK1 |
0.829 | 0.053 | 1 | 0.594 |
ATM |
0.829 | -0.005 | 1 | 0.770 |
AKT1 |
0.829 | 0.196 | -3 | 0.762 |
DNAPK |
0.829 | 0.097 | 1 | 0.761 |
PAK2 |
0.829 | 0.044 | -2 | 0.784 |
ERK1 |
0.829 | 0.071 | 1 | 0.608 |
MAK |
0.828 | 0.279 | -2 | 0.793 |
TGFBR1 |
0.828 | -0.005 | -2 | 0.784 |
CDK14 |
0.828 | 0.112 | 1 | 0.617 |
ALK4 |
0.828 | -0.038 | -2 | 0.814 |
CHK1 |
0.828 | 0.088 | -3 | 0.847 |
P38G |
0.827 | 0.070 | 1 | 0.519 |
GRK4 |
0.827 | -0.141 | -2 | 0.840 |
CDK12 |
0.827 | 0.058 | 1 | 0.588 |
NEK2 |
0.827 | 0.022 | 2 | 0.853 |
MARK2 |
0.827 | 0.105 | 4 | 0.743 |
VRK2 |
0.827 | 0.016 | 1 | 0.834 |
DYRK3 |
0.827 | 0.158 | 1 | 0.677 |
MPSK1 |
0.827 | 0.233 | 1 | 0.752 |
CDK17 |
0.826 | 0.062 | 1 | 0.520 |
TLK2 |
0.825 | 0.015 | 1 | 0.787 |
SMG1 |
0.825 | -0.003 | 1 | 0.784 |
CDK9 |
0.825 | 0.029 | 1 | 0.623 |
DYRK1B |
0.825 | 0.114 | 1 | 0.611 |
FAM20C |
0.824 | 0.002 | 2 | 0.582 |
CDK10 |
0.824 | 0.126 | 1 | 0.598 |
PLK1 |
0.824 | -0.083 | -2 | 0.804 |
MST3 |
0.823 | 0.143 | 2 | 0.866 |
CHAK1 |
0.823 | -0.049 | 2 | 0.815 |
MEK1 |
0.823 | -0.116 | 2 | 0.861 |
PRP4 |
0.822 | 0.105 | -3 | 0.760 |
PASK |
0.822 | 0.132 | -3 | 0.860 |
MAPKAPK5 |
0.821 | 0.018 | -3 | 0.745 |
WNK4 |
0.821 | 0.032 | -2 | 0.894 |
CDK16 |
0.821 | 0.091 | 1 | 0.539 |
MLK4 |
0.821 | -0.045 | 2 | 0.754 |
AKT3 |
0.821 | 0.210 | -3 | 0.703 |
MARK1 |
0.821 | 0.069 | 4 | 0.792 |
PKCT |
0.821 | 0.104 | 2 | 0.768 |
P70S6K |
0.821 | 0.118 | -3 | 0.742 |
CAMK1G |
0.820 | 0.067 | -3 | 0.780 |
CDK3 |
0.820 | 0.052 | 1 | 0.540 |
SSTK |
0.819 | 0.100 | 4 | 0.797 |
SNRK |
0.819 | -0.078 | 2 | 0.719 |
PLK4 |
0.819 | -0.032 | 2 | 0.654 |
TAO3 |
0.819 | 0.108 | 1 | 0.787 |
PHKG2 |
0.819 | 0.080 | -3 | 0.803 |
NEK5 |
0.819 | 0.047 | 1 | 0.809 |
ACVR2A |
0.818 | -0.056 | -2 | 0.775 |
ACVR2B |
0.818 | -0.051 | -2 | 0.788 |
SGK1 |
0.818 | 0.204 | -3 | 0.685 |
P38D |
0.818 | 0.083 | 1 | 0.544 |
ERK2 |
0.818 | -0.001 | 1 | 0.637 |
CK1E |
0.818 | 0.001 | -3 | 0.494 |
PERK |
0.817 | -0.049 | -2 | 0.825 |
MOK |
0.817 | 0.226 | 1 | 0.697 |
CAMK1D |
0.817 | 0.128 | -3 | 0.737 |
ALK2 |
0.817 | -0.062 | -2 | 0.794 |
MEKK2 |
0.817 | 0.007 | 2 | 0.837 |
MEKK1 |
0.816 | -0.032 | 1 | 0.799 |
DCAMKL2 |
0.816 | 0.048 | -3 | 0.831 |
DAPK3 |
0.816 | 0.141 | -3 | 0.824 |
IRAK4 |
0.815 | -0.006 | 1 | 0.757 |
PKCE |
0.815 | 0.136 | 2 | 0.758 |
SMMLCK |
0.815 | 0.069 | -3 | 0.817 |
MEK5 |
0.815 | -0.120 | 2 | 0.853 |
PLK3 |
0.815 | -0.108 | 2 | 0.773 |
DRAK1 |
0.814 | -0.079 | 1 | 0.721 |
ZAK |
0.814 | -0.063 | 1 | 0.765 |
CK1G1 |
0.814 | 0.009 | -3 | 0.487 |
ROCK2 |
0.814 | 0.225 | -3 | 0.819 |
GCK |
0.814 | 0.198 | 1 | 0.820 |
MEKK3 |
0.814 | -0.103 | 1 | 0.795 |
HRI |
0.814 | -0.117 | -2 | 0.848 |
GSK3A |
0.813 | 0.055 | 4 | 0.469 |
BRAF |
0.813 | -0.087 | -4 | 0.821 |
PKCI |
0.813 | 0.071 | 2 | 0.787 |
PAK5 |
0.812 | 0.067 | -2 | 0.650 |
LKB1 |
0.812 | 0.083 | -3 | 0.781 |
GSK3B |
0.812 | 0.016 | 4 | 0.460 |
MRCKB |
0.812 | 0.180 | -3 | 0.770 |
KHS1 |
0.812 | 0.277 | 1 | 0.813 |
TNIK |
0.811 | 0.192 | 3 | 0.806 |
GRK2 |
0.811 | -0.090 | -2 | 0.725 |
CDK2 |
0.811 | -0.071 | 1 | 0.678 |
MEKK6 |
0.809 | 0.087 | 1 | 0.800 |
PKN1 |
0.809 | 0.112 | -3 | 0.757 |
GAK |
0.809 | 0.091 | 1 | 0.828 |
HPK1 |
0.809 | 0.187 | 1 | 0.811 |
TLK1 |
0.809 | -0.098 | -2 | 0.834 |
MRCKA |
0.809 | 0.164 | -3 | 0.784 |
CHK2 |
0.809 | 0.145 | -3 | 0.698 |
TAO2 |
0.809 | 0.038 | 2 | 0.869 |
PAK4 |
0.809 | 0.064 | -2 | 0.659 |
ERK7 |
0.809 | 0.075 | 2 | 0.587 |
DAPK1 |
0.808 | 0.112 | -3 | 0.804 |
HGK |
0.808 | 0.139 | 3 | 0.802 |
BUB1 |
0.808 | 0.177 | -5 | 0.816 |
KHS2 |
0.808 | 0.251 | 1 | 0.822 |
CK1D |
0.808 | -0.002 | -3 | 0.441 |
NEK11 |
0.807 | -0.056 | 1 | 0.782 |
MINK |
0.807 | 0.149 | 1 | 0.811 |
PDK1 |
0.807 | 0.037 | 1 | 0.755 |
BMPR1A |
0.807 | -0.037 | 1 | 0.740 |
SBK |
0.807 | 0.170 | -3 | 0.652 |
MAP3K15 |
0.807 | 0.074 | 1 | 0.757 |
NEK4 |
0.806 | 0.042 | 1 | 0.799 |
CAMK1A |
0.806 | 0.136 | -3 | 0.712 |
JNK1 |
0.806 | 0.021 | 1 | 0.577 |
EEF2K |
0.806 | 0.059 | 3 | 0.764 |
CDK6 |
0.805 | 0.059 | 1 | 0.597 |
CK1A2 |
0.804 | -0.018 | -3 | 0.444 |
CDK4 |
0.804 | 0.056 | 1 | 0.577 |
PBK |
0.804 | 0.142 | 1 | 0.778 |
NEK8 |
0.804 | -0.094 | 2 | 0.851 |
LOK |
0.803 | 0.084 | -2 | 0.767 |
DMPK1 |
0.803 | 0.196 | -3 | 0.793 |
NEK1 |
0.803 | 0.071 | 1 | 0.784 |
MST2 |
0.802 | 0.004 | 1 | 0.827 |
CAMKK2 |
0.801 | -0.078 | -2 | 0.752 |
CAMKK1 |
0.801 | -0.134 | -2 | 0.758 |
PINK1 |
0.800 | -0.224 | 1 | 0.764 |
GRK3 |
0.799 | -0.077 | -2 | 0.681 |
CRIK |
0.799 | 0.182 | -3 | 0.769 |
TTBK1 |
0.799 | -0.167 | 2 | 0.653 |
LRRK2 |
0.799 | -0.018 | 2 | 0.876 |
IRAK1 |
0.799 | -0.213 | -1 | 0.741 |
ROCK1 |
0.798 | 0.173 | -3 | 0.784 |
TAK1 |
0.798 | -0.004 | 1 | 0.820 |
CK2A2 |
0.798 | 0.001 | 1 | 0.685 |
VRK1 |
0.797 | -0.027 | 2 | 0.856 |
YSK1 |
0.797 | 0.065 | 2 | 0.845 |
PDHK3_TYR |
0.796 | 0.242 | 4 | 0.876 |
PKG1 |
0.796 | 0.090 | -2 | 0.593 |
SLK |
0.794 | 0.006 | -2 | 0.708 |
MST1 |
0.794 | 0.001 | 1 | 0.808 |
PLK2 |
0.790 | -0.068 | -3 | 0.722 |
CK2A1 |
0.788 | -0.014 | 1 | 0.663 |
TESK1_TYR |
0.788 | 0.080 | 3 | 0.813 |
LIMK2_TYR |
0.788 | 0.168 | -3 | 0.852 |
MAP2K4_TYR |
0.787 | 0.078 | -1 | 0.872 |
PKMYT1_TYR |
0.787 | 0.085 | 3 | 0.782 |
PDHK4_TYR |
0.786 | 0.070 | 2 | 0.883 |
NEK3 |
0.786 | -0.048 | 1 | 0.749 |
OSR1 |
0.786 | 0.005 | 2 | 0.835 |
MEK2 |
0.786 | -0.188 | 2 | 0.839 |
STK33 |
0.785 | -0.155 | 2 | 0.642 |
MYO3B |
0.785 | 0.082 | 2 | 0.859 |
HASPIN |
0.784 | 0.006 | -1 | 0.684 |
TTK |
0.784 | 0.009 | -2 | 0.822 |
RIPK2 |
0.783 | -0.243 | 1 | 0.729 |
MAP2K6_TYR |
0.782 | -0.026 | -1 | 0.869 |
MAP2K7_TYR |
0.782 | -0.081 | 2 | 0.871 |
BIKE |
0.782 | 0.078 | 1 | 0.729 |
ASK1 |
0.782 | -0.018 | 1 | 0.742 |
TAO1 |
0.779 | 0.016 | 1 | 0.728 |
RET |
0.779 | 0.017 | 1 | 0.793 |
ABL2 |
0.778 | 0.094 | -1 | 0.802 |
PDHK1_TYR |
0.778 | -0.059 | -1 | 0.869 |
ROS1 |
0.778 | 0.057 | 3 | 0.697 |
EPHB4 |
0.778 | 0.029 | -1 | 0.816 |
BMPR2_TYR |
0.777 | -0.046 | -1 | 0.855 |
EPHA6 |
0.777 | 0.024 | -1 | 0.829 |
MYO3A |
0.777 | 0.019 | 1 | 0.774 |
PINK1_TYR |
0.776 | -0.154 | 1 | 0.799 |
TXK |
0.775 | 0.078 | 1 | 0.822 |
FGR |
0.775 | 0.046 | 1 | 0.851 |
TYRO3 |
0.775 | -0.022 | 3 | 0.721 |
MST1R |
0.775 | -0.030 | 3 | 0.738 |
TYK2 |
0.774 | -0.028 | 1 | 0.797 |
ABL1 |
0.774 | 0.069 | -1 | 0.796 |
LIMK1_TYR |
0.774 | -0.088 | 2 | 0.873 |
TNK2 |
0.774 | 0.050 | 3 | 0.659 |
CK1A |
0.773 | -0.034 | -3 | 0.356 |
LCK |
0.772 | 0.084 | -1 | 0.822 |
CSF1R |
0.772 | -0.019 | 3 | 0.713 |
AAK1 |
0.772 | 0.140 | 1 | 0.635 |
JAK2 |
0.772 | -0.033 | 1 | 0.792 |
YES1 |
0.771 | -0.017 | -1 | 0.842 |
YANK3 |
0.770 | -0.073 | 2 | 0.410 |
JAK1 |
0.770 | 0.092 | 1 | 0.756 |
BLK |
0.769 | 0.081 | -1 | 0.814 |
ITK |
0.769 | -0.007 | -1 | 0.795 |
HCK |
0.769 | -0.011 | -1 | 0.817 |
TNNI3K_TYR |
0.768 | 0.087 | 1 | 0.791 |
TNK1 |
0.768 | 0.038 | 3 | 0.714 |
FER |
0.767 | -0.113 | 1 | 0.860 |
DDR1 |
0.766 | -0.146 | 4 | 0.782 |
JAK3 |
0.765 | -0.105 | 1 | 0.761 |
ALPHAK3 |
0.765 | -0.127 | -1 | 0.768 |
NEK10_TYR |
0.765 | -0.005 | 1 | 0.675 |
SRMS |
0.764 | -0.078 | 1 | 0.839 |
BMX |
0.764 | -0.005 | -1 | 0.733 |
INSRR |
0.764 | -0.099 | 3 | 0.666 |
MERTK |
0.764 | -0.042 | 3 | 0.695 |
EPHB3 |
0.763 | -0.063 | -1 | 0.800 |
AXL |
0.763 | -0.067 | 3 | 0.694 |
STLK3 |
0.761 | -0.150 | 1 | 0.746 |
EPHB1 |
0.761 | -0.113 | 1 | 0.838 |
KDR |
0.761 | -0.069 | 3 | 0.668 |
PDGFRB |
0.760 | -0.146 | 3 | 0.716 |
EPHB2 |
0.760 | -0.086 | -1 | 0.791 |
FYN |
0.759 | 0.012 | -1 | 0.805 |
KIT |
0.759 | -0.126 | 3 | 0.704 |
EPHA4 |
0.759 | -0.100 | 2 | 0.767 |
FGFR2 |
0.758 | -0.169 | 3 | 0.705 |
TEC |
0.758 | -0.073 | -1 | 0.735 |
MET |
0.758 | -0.090 | 3 | 0.701 |
FLT3 |
0.757 | -0.151 | 3 | 0.713 |
WEE1_TYR |
0.756 | -0.060 | -1 | 0.770 |
PTK6 |
0.756 | -0.133 | -1 | 0.753 |
ALK |
0.755 | -0.111 | 3 | 0.617 |
EPHA1 |
0.755 | -0.067 | 3 | 0.679 |
FGFR1 |
0.755 | -0.169 | 3 | 0.675 |
BTK |
0.755 | -0.156 | -1 | 0.770 |
LTK |
0.755 | -0.104 | 3 | 0.640 |
TEK |
0.754 | -0.170 | 3 | 0.639 |
PDGFRA |
0.753 | -0.170 | 3 | 0.711 |
LYN |
0.752 | -0.079 | 3 | 0.636 |
EPHA7 |
0.752 | -0.100 | 2 | 0.776 |
FRK |
0.751 | -0.093 | -1 | 0.814 |
PTK2B |
0.751 | -0.072 | -1 | 0.770 |
NTRK1 |
0.751 | -0.194 | -1 | 0.812 |
DDR2 |
0.750 | -0.025 | 3 | 0.630 |
INSR |
0.750 | -0.150 | 3 | 0.658 |
EPHA3 |
0.748 | -0.156 | 2 | 0.744 |
NTRK3 |
0.747 | -0.133 | -1 | 0.778 |
FLT1 |
0.747 | -0.164 | -1 | 0.802 |
SRC |
0.747 | -0.075 | -1 | 0.803 |
ERBB2 |
0.746 | -0.194 | 1 | 0.755 |
NTRK2 |
0.746 | -0.221 | 3 | 0.668 |
FGFR3 |
0.746 | -0.193 | 3 | 0.676 |
CK1G3 |
0.745 | -0.059 | -3 | 0.312 |
EPHA5 |
0.743 | -0.133 | 2 | 0.750 |
FLT4 |
0.743 | -0.223 | 3 | 0.664 |
MATK |
0.742 | -0.135 | -1 | 0.737 |
EPHA8 |
0.740 | -0.137 | -1 | 0.785 |
EGFR |
0.739 | -0.122 | 1 | 0.663 |
CSK |
0.739 | -0.170 | 2 | 0.782 |
PTK2 |
0.736 | -0.056 | -1 | 0.749 |
SYK |
0.736 | -0.060 | -1 | 0.750 |
FGFR4 |
0.735 | -0.147 | -1 | 0.763 |
YANK2 |
0.735 | -0.113 | 2 | 0.427 |
MUSK |
0.734 | -0.138 | 1 | 0.658 |
IGF1R |
0.731 | -0.181 | 3 | 0.590 |
EPHA2 |
0.730 | -0.140 | -1 | 0.750 |
ERBB4 |
0.726 | -0.117 | 1 | 0.683 |
CK1G2 |
0.722 | -0.087 | -3 | 0.402 |
ZAP70 |
0.722 | -0.036 | -1 | 0.695 |
FES |
0.717 | -0.194 | -1 | 0.717 |