Motif 159 (n=335)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A1L170	C1orf226	S237	ochoa	Uncharacterized protein C1orf226	None
A2RUS2	DENND3	S472	ochoa\|psp	DENN domain-containing protein 3	Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250\|UniProtKB:A2RT67, ECO:0000269\|PubMed:20937701}.
A4D161	FAM221A	S216	ochoa	Protein FAM221A	None
A6NKD9	CCDC85C	S246	ochoa	Coiled-coil domain-containing protein 85C	May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250\|UniProtKB:E9Q6B2, ECO:0000305\|PubMed:25009281}.
A8MT19	RHPN2P1	S549	ochoa	Putative rhophilin-2-like protein RHPN2P1 (Rhophilin-2 pseudogene 1)	None
A8MVW0	FAM171A2	S737	ochoa	Protein FAM171A2	None
B8ZZF3	None	S239	ochoa	Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (Mediator complex subunit 26)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. {ECO:0000256\|ARBA:ARBA00057523}.
O00221	NFKBIE	S161	psp	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)	Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250\|UniProtKB:O54910, ECO:0000269\|PubMed:9135156, ECO:0000269\|PubMed:9315679}.
O00408	PDE2A	S909	ochoa	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)	cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027). {ECO:0000269\|PubMed:15938621, ECO:0000269\|PubMed:24705027, ECO:0000269\|PubMed:29392776, ECO:0000269\|PubMed:9210593}.; FUNCTION: [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107). {ECO:0000250\|UniProtKB:Q922S4, ECO:0000269\|PubMed:28463107}.
O14492	SH2B2	S332	ochoa	SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. {ECO:0000269\|PubMed:10374881, ECO:0000269\|PubMed:12400014, ECO:0000269\|PubMed:15378031, ECO:0000269\|PubMed:9989826}.
O14523	C2CD2L	S411	ochoa	Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)	Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269\|PubMed:28209843}.
O14530	TXNDC9	S181	ochoa	Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4)	Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. {ECO:0000269\|PubMed:16415341}.
O14654	IRS4	S937	ochoa	Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269\|PubMed:10531310, ECO:0000269\|PubMed:10594015, ECO:0000269\|PubMed:12639902, ECO:0000269\|PubMed:17408801, ECO:0000269\|PubMed:9553137}.
O14745	NHERF1	S269	ochoa\|psp	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)	Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269\|PubMed:10499588, ECO:0000269\|PubMed:18784102, ECO:0000269\|PubMed:9096337, ECO:0000269\|PubMed:9430655}.
O14994	SYN3	S457	ochoa	Synapsin-3 (Synapsin III)	May be involved in the regulation of neurotransmitter release and synaptogenesis.
O15049	N4BP3	S148	ochoa	NEDD4-binding protein 3 (N4BP3)	Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250\|UniProtKB:A0A1L8GXY6, ECO:0000269\|PubMed:34880843}.
O15409	FOXP2	S439	ochoa	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein)	Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
O43166	SIPA1L1	S1647	ochoa	Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}.
O43310	CTIF	S299	ochoa	CBP80/20-dependent translation initiation factor	Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269\|PubMed:19648179}.
O43379	WDR62	S995	ochoa	WD repeat-containing protein 62	Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269\|PubMed:20729831, ECO:0000269\|PubMed:20890278, ECO:0000269\|PubMed:26297806}.
O43561	LAT	S40	ochoa	Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)	Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PubMed:23514740, PubMed:25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269\|PubMed:10072481, ECO:0000269\|PubMed:23514740, ECO:0000269\|PubMed:25907557}.
O60245	PCDH7	S998	ochoa	Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh)	None
O60292	SIPA1L3	S1667	ochoa	Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)	Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269\|PubMed:26231217}.
O60303	KATNIP	S691	ochoa	Katanin-interacting protein	May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex. {ECO:0000269\|PubMed:26714646}.
O60307	MAST3	S85	ochoa	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)	None
O60333	KIF1B	S1605	ochoa	Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3)	Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269\|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250\|UniProtKB:Q60575, ECO:0000269\|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269\|PubMed:16225668}.
O60341	KDM1A	S687	psp	Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)	Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269\|PubMed:12032298, ECO:0000269\|PubMed:15620353, ECO:0000269\|PubMed:15811342, ECO:0000269\|PubMed:16079794, ECO:0000269\|PubMed:16079795, ECO:0000269\|PubMed:16140033, ECO:0000269\|PubMed:16223729, ECO:0000269\|PubMed:16885027, ECO:0000269\|PubMed:16956976, ECO:0000269\|PubMed:17805299, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:20562920, ECO:0000269\|PubMed:21300290, ECO:0000269\|PubMed:23721412, ECO:0000269\|PubMed:27292636, ECO:0000269\|PubMed:29358331, ECO:0000269\|PubMed:29691401, ECO:0000269\|PubMed:34655521, ECO:0000269\|PubMed:34906447}.
O60716	CTNND1	S346	ochoa	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269\|PubMed:10207085, ECO:0000269\|PubMed:14610055, ECO:0000269\|PubMed:17344476, ECO:0000269\|PubMed:18343367, ECO:0000269\|PubMed:20371349}.
O75037	KIF21B	S1272	ochoa	Kinesin-like protein KIF21B	Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250\|UniProtKB:Q9QXL1}.
O75369	FLNB	S1523	ochoa	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75376	NCOR1	S1734	ochoa	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250\|UniProtKB:Q60974, ECO:0000269\|PubMed:14527417, ECO:0000269\|PubMed:20812024}.
O75533	SF3B1	S73	ochoa	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250\|UniProtKB:Q99NB9, ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
O75533	SF3B1	S129	ochoa	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250\|UniProtKB:Q99NB9, ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
O75533	SF3B1	S349	ochoa	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250\|UniProtKB:Q99NB9, ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
O75665	OFD1	Y751	ochoa	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250\|UniProtKB:Q80Z25, ECO:0000269\|PubMed:33934390}.
O75937	DNAJC8	S52	ochoa	DnaJ homolog subfamily C member 8 (Splicing protein spf31)	Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269\|PubMed:27133716}.
O75962	TRIO	S2671	ochoa	Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)	Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250\|UniProtKB:F1M0Z1, ECO:0000269\|PubMed:10341202, ECO:0000269\|PubMed:22155786, ECO:0000269\|PubMed:27418539, ECO:0000269\|PubMed:32109419, ECO:0000269\|PubMed:8643598}.
O75970	MPDZ	S1584	ochoa	Multiple PDZ domain protein (Multi-PDZ domain protein 1)	Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250\|UniProtKB:O55164, ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:15312654}.
O94806	PRKD3	S213	ochoa	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)	Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
O94885	SASH1	S821	ochoa	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)	Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269\|PubMed:23333244, ECO:0000269\|PubMed:23776175, ECO:0000269\|PubMed:25315659}.
O94979	SEC31A	S352	ochoa	Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250\|UniProtKB:Q9Z2Q1, ECO:0000269\|PubMed:10788476}.
O95049	TJP3	S591	ochoa	Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250\|UniProtKB:O62683, ECO:0000250\|UniProtKB:Q9QXY1, ECO:0000269\|PubMed:16129888, ECO:0000269\|PubMed:21411630}.
O95149	SNUPN	S340	ochoa	Snurportin-1 (RNA U transporter 1)	Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269\|PubMed:10209022, ECO:0000269\|PubMed:15920472, ECO:0000269\|PubMed:16030253, ECO:0000269\|PubMed:38413582, ECO:0000269\|PubMed:9670026}.
O95208	EPN2	S473	ochoa	Epsin-2 (EPS-15-interacting protein 2)	Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269\|PubMed:10567358}.
O95400	CD2BP2	S153	ochoa	CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) (U5 snRNP 52K protein) (U5-52K)	Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. {ECO:0000269\|PubMed:15840814}.
O95402	MED26	S231	ochoa	Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95436	SLC34A2	S55	ochoa	Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)	Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269\|PubMed:10329428}.
O95490	ADGRL2	S1374	ochoa	Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)	Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250\|UniProtKB:Q80TS3, ECO:0000250\|UniProtKB:Q8JZZ7}.
O95721	SNAP29	S163	ochoa	Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)	SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269\|PubMed:23217709, ECO:0000269\|PubMed:25686250, ECO:0000269\|PubMed:25686604}.
O95785	WIZ	S1127	ochoa	Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803)	May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity). {ECO:0000250}.
O95833	CLIC3	S49	ochoa	Chloride intracellular channel protein 3 (Glutaredoxin-like oxidoreductase CLIC3) (EC 1.8.-.-)	In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:28198360, PubMed:37759794). Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding (PubMed:28198360). Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. {ECO:0000269\|PubMed:28198360, ECO:0000269\|PubMed:32066374, ECO:0000269\|PubMed:37759794, ECO:0000269\|PubMed:9880541}.
O95865	DDAH2	S245	psp	Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein)	Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250\|UniProtKB:Q99LD8, ECO:0000269\|PubMed:21493890, ECO:0000269\|PubMed:33850055, ECO:0000269\|PubMed:37296100, ECO:0000305\|PubMed:10493931, ECO:0000305\|PubMed:21493890, ECO:0000305\|PubMed:37296100}.
O96013	PAK4	S195	ochoa	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)	Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269\|PubMed:11278822, ECO:0000269\|PubMed:11313478, ECO:0000269\|PubMed:14560027, ECO:0000269\|PubMed:15660133, ECO:0000269\|PubMed:20507994, ECO:0000269\|PubMed:20631255, ECO:0000269\|PubMed:20805321, ECO:0000269\|PubMed:26598620, ECO:0000269\|PubMed:26607847}.
O96013	PAK4	S267	ochoa	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)	Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269\|PubMed:11278822, ECO:0000269\|PubMed:11313478, ECO:0000269\|PubMed:14560027, ECO:0000269\|PubMed:15660133, ECO:0000269\|PubMed:20507994, ECO:0000269\|PubMed:20631255, ECO:0000269\|PubMed:20805321, ECO:0000269\|PubMed:26598620, ECO:0000269\|PubMed:26607847}.
P02042	HBD	S45	ochoa	Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain)	Involved in oxygen transport from the lung to the various peripheral tissues.
P04150	NR3C1	S125	ochoa	Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)	Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250\|UniProtKB:P06537, ECO:0000269\|PubMed:25775514, ECO:0000269\|PubMed:27120390, ECO:0000269\|PubMed:28139699, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250\|UniProtKB:P06537, ECO:0000269\|PubMed:11435610, ECO:0000269\|PubMed:15769988, ECO:0000269\|PubMed:15866175, ECO:0000269\|PubMed:17635946, ECO:0000269\|PubMed:19141540, ECO:0000269\|PubMed:19248771, ECO:0000269\|PubMed:20484466, ECO:0000269\|PubMed:21664385, ECO:0000269\|PubMed:23303127, ECO:0000269\|PubMed:23820903, ECO:0000269\|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250\|UniProtKB:P06537, ECO:0000269\|PubMed:19248771, ECO:0000269\|PubMed:20484466, ECO:0000269\|PubMed:26711253, ECO:0000269\|PubMed:7769088, ECO:0000269\|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269\|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269\|PubMed:11435610, ECO:0000269\|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269\|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269\|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269\|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269\|PubMed:15866175, ECO:0000269\|PubMed:23303127, ECO:0000269\|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269\|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269\|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269\|PubMed:15866175, ECO:0000269\|PubMed:23303127, ECO:0000269\|PubMed:23820903}.
P04180	LCAT	S205	psp	Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)	Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755). {ECO:0000269\|PubMed:10329423, ECO:0000269\|PubMed:10722751, ECO:0000269\|PubMed:12354767, ECO:0000269\|PubMed:14636062, ECO:0000269\|PubMed:19065001, ECO:0000269\|PubMed:24620755, ECO:0000269\|PubMed:26195816, ECO:0000269\|PubMed:8016111, ECO:0000269\|PubMed:8820107}.
P06400	RB1	S855	ochoa	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250\|UniProtKB:P13405, ECO:0000250\|UniProtKB:P33568, ECO:0000269\|PubMed:10499802, ECO:0000269\|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269\|PubMed:1316611, ECO:0000269\|PubMed:17974914, ECO:0000269\|PubMed:18701596, ECO:0000269\|PubMed:2839300, ECO:0000269\|PubMed:8892909}.
P08651	NFIC	S248	ochoa	Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
P10398	ARAF	S157	ochoa	Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)	Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269\|PubMed:22609986, ECO:0000269\|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269\|PubMed:22609986}.
P11274	BCR	S993	ochoa	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:1903516, PubMed:7479768). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:23940119, PubMed:7479768). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250\|UniProtKB:Q6PAJ1, ECO:0000269\|PubMed:1657398, ECO:0000269\|PubMed:17116687, ECO:0000269\|PubMed:1903516, ECO:0000269\|PubMed:23940119, ECO:0000269\|PubMed:7479768}.
P15291	B4GALT1	S73	ochoa	Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]	[Beta-1,4-galactosyltransferase 1]: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269\|PubMed:34855475}.; FUNCTION: [Processed beta-1,4-galactosyltransferase 1]: The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. {ECO:0000269\|PubMed:16157350}.
P15923	TCF3	S328	ochoa	Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)	Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity). {ECO:0000250\|UniProtKB:P15806, ECO:0000269\|PubMed:2493990}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000269\|PubMed:31696227}.
P16591	FER	S715	ochoa	Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)	Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269\|PubMed:12972546, ECO:0000269\|PubMed:14517306, ECO:0000269\|PubMed:19147545, ECO:0000269\|PubMed:19339212, ECO:0000269\|PubMed:19738202, ECO:0000269\|PubMed:20111072, ECO:0000269\|PubMed:21518868, ECO:0000269\|PubMed:22223638, ECO:0000269\|PubMed:7623846, ECO:0000269\|PubMed:9722593}.
P16871	IL7R	S366	ochoa	Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)	Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
P18031	PTPN1	S295	ochoa	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269\|PubMed:18819921, ECO:0000269\|PubMed:21135139, ECO:0000269\|PubMed:22169477}.
P18583	SON	S1670	ochoa	Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)	RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269\|PubMed:20581448, ECO:0000269\|PubMed:21504830, ECO:0000269\|PubMed:27545680}.
P21333	FLNA	S1454	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1520	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1551	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	S1976	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P22681	CBL	S439	ochoa	E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)	E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors (PubMed:10514377, PubMed:11896602, PubMed:14661060, PubMed:14739300, PubMed:15190072, PubMed:17509076, PubMed:18374639, PubMed:19689429, PubMed:21596750, PubMed:28381567). Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:10514377, PubMed:14661060, PubMed:14739300, PubMed:17094949, PubMed:17509076, PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling (PubMed:15190072, PubMed:18374639, PubMed:21596750). Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation (PubMed:11896602). Ubiquitinates EGFR and SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface (PubMed:28381567). Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis (PubMed:15190072, PubMed:18374639). Essential for osteoclastic bone resorption (PubMed:14739300). The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14739300). May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250\|UniProtKB:P22682, ECO:0000269\|PubMed:10514377, ECO:0000269\|PubMed:11896602, ECO:0000269\|PubMed:14661060, ECO:0000269\|PubMed:14739300, ECO:0000269\|PubMed:15190072, ECO:0000269\|PubMed:17094949, ECO:0000269\|PubMed:17509076, ECO:0000269\|PubMed:17974561, ECO:0000269\|PubMed:18374639, ECO:0000269\|PubMed:19689429, ECO:0000269\|PubMed:21596750, ECO:0000269\|PubMed:28381567}.
P25054	APC	S2034	psp	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250\|UniProtKB:Q61315, ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:17293347, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19151759, ECO:0000269\|PubMed:19893577, ECO:0000269\|PubMed:20937854}.
P25440	BRD2	S50	ochoa	Bromodomain-containing protein 2 (O27.1.1)	Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:17148447, PubMed:17848202, PubMed:18406326, PubMed:20048151, PubMed:20709061, PubMed:20871596). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:28262505). Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation (PubMed:35410381). Also recognizes and binds acetylated non-histone proteins, such as STAT3 (PubMed:28262505). Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin (PubMed:28262505). In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation (PubMed:37731000). Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively) (PubMed:37731000). {ECO:0000269\|PubMed:17148447, ECO:0000269\|PubMed:17848202, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:20048151, ECO:0000269\|PubMed:20709061, ECO:0000269\|PubMed:20871596, ECO:0000269\|PubMed:28262505, ECO:0000269\|PubMed:35410381, ECO:0000269\|PubMed:37731000}.
P26045	PTPN3	S359	ochoa\|psp	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
P33981	TTK	S455	ochoa	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)	Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269\|PubMed:18243099, ECO:0000269\|PubMed:28441529, ECO:0000269\|PubMed:29162720, ECO:0000269\|PubMed:30785839}.
P37275	ZEB1	S673	ochoa	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250\|UniProtKB:Q64318, ECO:0000269\|PubMed:19935649, ECO:0000269\|PubMed:20175752, ECO:0000269\|PubMed:20418909}.
P42566	EPS15	S107	ochoa	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:16903783, ECO:0000269\|PubMed:18362181, ECO:0000269\|PubMed:19458185, ECO:0000269\|PubMed:22648170}.
P42704	LRPPRC	S121	ochoa	Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)	May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269\|PubMed:11585913, ECO:0000269\|PubMed:12832482, ECO:0000269\|PubMed:15081402, ECO:0000269\|PubMed:15139850, ECO:0000269\|PubMed:15272088, ECO:0000269\|PubMed:17050673, ECO:0000269\|PubMed:19262567, ECO:0000269\|PubMed:23822101, ECO:0000269\|PubMed:28325843}.
P42858	HTT	S419	ochoa\|psp	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	[Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269\|PubMed:24459296}.
P43146	DCC	S1216	ochoa	Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269\|PubMed:8187090, ECO:0000269\|PubMed:8861902}.
P46013	MKI67	S1098	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	S1693	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46937	YAP1	S61	ochoa\|psp	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P47974	ZFP36L2	S57	ochoa	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250\|UniProtKB:P23949, ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496, ECO:0000269\|PubMed:25106868, ECO:0000269\|PubMed:34611029}.
P47974	ZFP36L2	S465	ochoa	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. {ECO:0000250\|UniProtKB:P23949, ECO:0000269\|PubMed:14981510, ECO:0000269\|PubMed:20506496, ECO:0000269\|PubMed:25106868, ECO:0000269\|PubMed:34611029}.
P49006	MARCKSL1	S36	ochoa	MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)	Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250\|UniProtKB:P28667, ECO:0000269\|PubMed:22751924}.
P49327	FASN	S1398	ochoa	Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269\|PubMed:16215233, ECO:0000269\|PubMed:16969344, ECO:0000269\|PubMed:26851298, ECO:0000269\|PubMed:7567999, ECO:0000269\|PubMed:8962082, ECO:0000269\|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269\|PubMed:34320401}.
P49674	CSNK1E	S389	ochoa\|psp	Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250\|UniProtKB:Q9JMK2, ECO:0000269\|PubMed:12556519, ECO:0000269\|PubMed:15070676, ECO:0000269\|PubMed:15917222, ECO:0000269\|PubMed:16790549, ECO:0000269\|PubMed:23413191, ECO:0000305\|PubMed:7797465}.
P49792	RANBP2	S1374	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P51003	PAPOLA	S717	ochoa	Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)	Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269\|PubMed:19224921}.
P55196	AFDN	S1501	ochoa	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250\|UniProtKB:O35889, ECO:0000250\|UniProtKB:Q9QZQ1, ECO:0000269\|PubMed:11024295, ECO:0000269\|PubMed:30463011}.
P56645	PER3	S923	ochoa	Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)	Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK\|NPAS2-BMAL1\|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme. {ECO:0000269\|PubMed:17346965, ECO:0000269\|PubMed:19716732, ECO:0000269\|PubMed:24439663, ECO:0000269\|PubMed:24577121, ECO:0000269\|PubMed:26903630}.
P57679	EVC	S135	ochoa	EvC complex member EVC (DWF-1) (Ellis-van Creveld syndrome protein)	Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. {ECO:0000250\|UniProtKB:P57680}.
P60174	TPI1	S21	psp	Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)	Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269\|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250\|UniProtKB:P00939}.
P68104	EEF1A1	S224	ochoa	Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)	Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250\|UniProtKB:P68105, ECO:0000269\|PubMed:17177976, ECO:0000269\|PubMed:26593721, ECO:0000269\|PubMed:26651998, ECO:0000269\|PubMed:36123449, ECO:0000269\|PubMed:36264623, ECO:0000269\|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269\|PubMed:33495306}.
P68871	HBB	S45	ochoa	Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]	Involved in oxygen transport from the lung to the various peripheral tissues. {ECO:0000269\|PubMed:28066926}.; FUNCTION: LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; FUNCTION: [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
P81408	ENTREP3	S466	ochoa	Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)	None
Q00613	HSF1	S326	ochoa\|psp	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)	Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269\|PubMed:10359787, ECO:0000269\|PubMed:11447121, ECO:0000269\|PubMed:11583998, ECO:0000269\|PubMed:12659875, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:14707147, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:16278218, ECO:0000269\|PubMed:17897941, ECO:0000269\|PubMed:18451878, ECO:0000269\|PubMed:1871105, ECO:0000269\|PubMed:18794143, ECO:0000269\|PubMed:1986252, ECO:0000269\|PubMed:25963659, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:26727489, ECO:0000269\|PubMed:26754925, ECO:0000269\|PubMed:34723967, ECO:0000269\|PubMed:7623826, ECO:0000269\|PubMed:7760831, ECO:0000269\|PubMed:7935471, ECO:0000269\|PubMed:8455624, ECO:0000269\|PubMed:8940068, ECO:0000269\|PubMed:8946918, ECO:0000269\|PubMed:9121459, ECO:0000269\|PubMed:9341107, ECO:0000269\|PubMed:9499401, ECO:0000269\|PubMed:9535852, ECO:0000269\|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269\|PubMed:27189267}.
Q01196	RUNX1	S257	ochoa	Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)	Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250\|UniProtKB:Q03347, ECO:0000269\|PubMed:10207087, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:14970218, ECO:0000269\|PubMed:17377532, ECO:0000269\|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250\|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269\|PubMed:9199349}.
Q02078	MEF2A	S210	ochoa	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269\|PubMed:11904443, ECO:0000269\|PubMed:12691662, ECO:0000269\|PubMed:15834131, ECO:0000269\|PubMed:16371476, ECO:0000269\|PubMed:16484498, ECO:0000269\|PubMed:16563226, ECO:0000269\|PubMed:21468593, ECO:0000269\|PubMed:9858528}.
Q02446	SP4	S216	ochoa	Transcription factor Sp4 (SPR-1)	Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Q04206	RELA	S276	psp	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269\|PubMed:10928981, ECO:0000269\|PubMed:12748188, ECO:0000269\|PubMed:15790681, ECO:0000269\|PubMed:17000776, ECO:0000269\|PubMed:17620405, ECO:0000269\|PubMed:19058135, ECO:0000269\|PubMed:19103749, ECO:0000269\|PubMed:20547752, ECO:0000269\|PubMed:33440148}.
Q06187	BTK	S342	ochoa	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269\|PubMed:11606584, ECO:0000269\|PubMed:16415872, ECO:0000269\|PubMed:16517732, ECO:0000269\|PubMed:16738337, ECO:0000269\|PubMed:17932028, ECO:0000269\|PubMed:25704810, ECO:0000269\|PubMed:34554188, ECO:0000269\|PubMed:9012831, ECO:0000303\|PubMed:19290921, ECO:0000303\|PubMed:9751072}.
Q07157	TJP1	S617	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07157	TJP1	S1570	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07617	SPAG1	S560	ochoa	Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1)	May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity. {ECO:0000250, ECO:0000269\|PubMed:11517287, ECO:0000269\|PubMed:1299558}.
Q07890	SOS2	S1132	ochoa	Son of sevenless homolog 2 (SOS-2)	Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000250\|UniProtKB:Q62245}.
Q08174	PCDH1	S971	ochoa	Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)	May be involved in cell-cell interaction processes and in cell adhesion.
Q08379	GOLGA2	S438	ochoa	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)	Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250\|UniProtKB:Q62839, ECO:0000250\|UniProtKB:Q921M4, ECO:0000269\|PubMed:16489344, ECO:0000269\|PubMed:17314401, ECO:0000269\|PubMed:18045989, ECO:0000269\|PubMed:19109421, ECO:0000269\|PubMed:19242490, ECO:0000269\|PubMed:26165940, ECO:0000305\|PubMed:26363069}.
Q09666	AHNAK	S4900	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q0VDD7	BRME1	S77	ochoa	Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)	Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250\|UniProtKB:Q6DIA7}.
Q0VF96	CGNL1	S415	ochoa	Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin)	May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269\|PubMed:22891260}.
Q12802	AKAP13	S864	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q12802	AKAP13	S1226	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q12802	AKAP13	S1602	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q13136	PPFIA1	S668	ochoa	Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)	May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269\|PubMed:7796809}.
Q13191	CBLB	S634	ochoa	E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250\|UniProtKB:Q3TTA7, ECO:0000269\|PubMed:10022120, ECO:0000269\|PubMed:10086340, ECO:0000269\|PubMed:11087752, ECO:0000269\|PubMed:11526404, ECO:0000269\|PubMed:14661060, ECO:0000269\|PubMed:20525694}.
Q13421	MSLN	S200	ochoa	Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]	Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Q13443	ADAM9	S799	ochoa	Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase)	Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. {ECO:0000250\|UniProtKB:Q61072}.; FUNCTION: [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). {ECO:0000269\|PubMed:12054541}.
Q13480	GAB1	S257	ochoa	GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269\|PubMed:29408807}.
Q13546	RIPK1	S262	psp	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250\|UniProtKB:Q60855, ECO:0000269\|PubMed:11101870, ECO:0000269\|PubMed:15310755, ECO:0000269\|PubMed:17389591, ECO:0000269\|PubMed:17703191, ECO:0000269\|PubMed:19524512, ECO:0000269\|PubMed:19524513, ECO:0000269\|PubMed:24144979, ECO:0000269\|PubMed:29440439, ECO:0000269\|PubMed:30988283, ECO:0000269\|PubMed:31827280, ECO:0000269\|PubMed:31827281, ECO:0000269\|PubMed:32657447, ECO:0000269\|PubMed:35831301}.
Q13586	STIM1	S521	ochoa\|psp	Stromal interaction molecule 1	Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269\|PubMed:15866891, ECO:0000269\|PubMed:16005298, ECO:0000269\|PubMed:16208375, ECO:0000269\|PubMed:16537481, ECO:0000269\|PubMed:16733527, ECO:0000269\|PubMed:16766533, ECO:0000269\|PubMed:16807233, ECO:0000269\|PubMed:18854159, ECO:0000269\|PubMed:19182790, ECO:0000269\|PubMed:19249086, ECO:0000269\|PubMed:19622606, ECO:0000269\|PubMed:19706554, ECO:0000269\|PubMed:22464749, ECO:0000269\|PubMed:24069340, ECO:0000269\|PubMed:24351972, ECO:0000269\|PubMed:24591628, ECO:0000269\|PubMed:24621671, ECO:0000269\|PubMed:25326555, ECO:0000269\|PubMed:26322679, ECO:0000269\|PubMed:28219928, ECO:0000269\|PubMed:32415068}.
Q13586	STIM1	S595	ochoa	Stromal interaction molecule 1	Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). {ECO:0000269\|PubMed:15866891, ECO:0000269\|PubMed:16005298, ECO:0000269\|PubMed:16208375, ECO:0000269\|PubMed:16537481, ECO:0000269\|PubMed:16733527, ECO:0000269\|PubMed:16766533, ECO:0000269\|PubMed:16807233, ECO:0000269\|PubMed:18854159, ECO:0000269\|PubMed:19182790, ECO:0000269\|PubMed:19249086, ECO:0000269\|PubMed:19622606, ECO:0000269\|PubMed:19706554, ECO:0000269\|PubMed:22464749, ECO:0000269\|PubMed:24069340, ECO:0000269\|PubMed:24351972, ECO:0000269\|PubMed:24591628, ECO:0000269\|PubMed:24621671, ECO:0000269\|PubMed:25326555, ECO:0000269\|PubMed:26322679, ECO:0000269\|PubMed:28219928, ECO:0000269\|PubMed:32415068}.
Q13625	TP53BP2	S416	ochoa	Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269\|PubMed:11684014, ECO:0000269\|PubMed:12524540, ECO:0000269\|PubMed:12694406, ECO:0000269\|PubMed:19377511}.
Q13905	RAPGEF1	S253	ochoa	Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)	Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269\|PubMed:12432078, ECO:0000269\|PubMed:17724123, ECO:0000269\|PubMed:21840392, ECO:0000269\|PubMed:7806500}.
Q14118	DAG1	S813	ochoa	Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250\|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269\|PubMed:16254364, ECO:0000269\|PubMed:17360738, ECO:0000269\|PubMed:19324387, ECO:0000269\|PubMed:9851927}.
Q14151	SAFB2	S827	ochoa	Scaffold attachment factor B2 (SAF-B2)	Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14153	FAM53B	S166	ochoa	Protein FAM53B (Protein simplet)	Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269\|PubMed:25183871}.
Q14315	FLNC	S1545	ochoa	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250\|UniProtKB:Q8VHX6, ECO:0000269\|PubMed:34405687}.
Q14573	ITPR3	S1702	ochoa	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (IP3 receptor isoform 3) (IP3R-3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)	Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (PubMed:32949214, PubMed:37898605, PubMed:8081734, PubMed:8288584). 1D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (PubMed:30013099, PubMed:35301323, PubMed:37898605). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (PubMed:30013099, PubMed:35301323, PubMed:37898605). {ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:32949214, ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0000269\|PubMed:8081734, ECO:0000269\|PubMed:8288584}.
Q14674	ESPL1	S1552	psp	Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)	Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269\|PubMed:10411507, ECO:0000269\|PubMed:11509732}.
Q14678	KANK1	S128	ochoa	KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)	Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250\|UniProtKB:E9Q238, ECO:0000269\|PubMed:16968744, ECO:0000269\|PubMed:18458160, ECO:0000269\|PubMed:19171758, ECO:0000269\|PubMed:22084092, ECO:0000269\|PubMed:24120883, ECO:0000269\|PubMed:25961457, ECO:0000269\|PubMed:27410476, ECO:0000305\|PubMed:12133830}.
Q14686	NCOA6	S1240	ochoa	Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Q14738	PPP2R5D	S90	ochoa	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q15390	MTFR1	S119	ochoa	Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region)	May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). {ECO:0000250}.
Q15528	MED22	S162	ochoa	Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Q15652	JMJD1C	S1223	ochoa	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8)	Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}.
Q15750	TAB1	S457	psp	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269\|PubMed:10838074, ECO:0000269\|PubMed:11847341, ECO:0000269\|PubMed:14592977, ECO:0000269\|PubMed:18021073, ECO:0000269\|PubMed:22307082, ECO:0000269\|PubMed:24403530, ECO:0000269\|PubMed:25260751, ECO:0000269\|PubMed:29229647, ECO:0000269\|PubMed:37832545}.
Q15772	SPEG	S513	ochoa	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.
Q15878	CACNA1E	S793	ochoa	Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. {ECO:0000269\|PubMed:30343943, ECO:0000269\|PubMed:7536609}.; FUNCTION: [Isoform 3]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. {ECO:0000269\|PubMed:8071363}.
Q16204	CCDC6	S341	ochoa	Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)	None
Q16625	OCLN	S408	ochoa\|psp	Occludin	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269\|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269\|PubMed:19182773, ECO:0000269\|PubMed:20375010}.
Q16665	HIF1A	S576	psp	Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)	Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (PubMed:22009797). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300 (PubMed:16543236, PubMed:9887100). Activity is enhanced by interaction with NCOA1 and/or NCOA2 (PubMed:10594042). Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042). Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (PubMed:19528298). {ECO:0000250\|UniProtKB:Q61221, ECO:0000269\|PubMed:10202154, ECO:0000269\|PubMed:10594042, ECO:0000269\|PubMed:11292861, ECO:0000269\|PubMed:11566883, ECO:0000269\|PubMed:15465032, ECO:0000269\|PubMed:16543236, ECO:0000269\|PubMed:16973622, ECO:0000269\|PubMed:17610843, ECO:0000269\|PubMed:18658046, ECO:0000269\|PubMed:19528298, ECO:0000269\|PubMed:20624928, ECO:0000269\|PubMed:22009797, ECO:0000269\|PubMed:30125331, ECO:0000269\|PubMed:9887100}.; FUNCTION: (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent pro-inflammatory state (PubMed:32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed:32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed:32697943). {ECO:0000269\|PubMed:32697943}.
Q2LD37	BLTP1	S4613	ochoa	Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein)	Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269\|PubMed:30906834, ECO:0000269\|PubMed:31540829, ECO:0000305\|PubMed:35015055, ECO:0000305\|PubMed:35491307}.
Q3YBM2	TMEM176B	S245	ochoa	Transmembrane protein 176B (Protein LR8)	May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). {ECO:0000250}.
Q53ET0	CRTC2	S274	ochoa	CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:14536081, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:16809310, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223}.
Q5JXC2	MIIP	S113	ochoa	Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45)	Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269\|PubMed:14617774}.
Q5SW79	CEP170	S958	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5T5C0	STXBP5	S692	ochoa	Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1)	Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.
Q5TH69	ARFGEF3	S1049	ochoa	Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3)	Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786). {ECO:0000250\|UniProtKB:Q3UGY8, ECO:0000269\|PubMed:19496786}.
Q5VT52	RPRD2	S414	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q5VTE0	EEF1A1P5	S224	ochoa	Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5)	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.
Q5VUA4	ZNF318	S1717	ochoa	Zinc finger protein 318 (Endocrine regulatory protein)	[Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250\|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250\|UniProtKB:Q99PP2}.
Q5VUB5	FAM171A1	S360	ochoa	Protein FAM171A1 (Astroprincin) (APCN)	Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269\|PubMed:30312582}.
Q5VUB5	FAM171A1	S644	ochoa	Protein FAM171A1 (Astroprincin) (APCN)	Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. {ECO:0000269\|PubMed:30312582}.
Q5VWQ8	DAB2IP	S949	ochoa	Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)	Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Also mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6), Ras and RAB40C (PubMed:29156729). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269\|PubMed:12813029, ECO:0000269\|PubMed:17389591, ECO:0000269\|PubMed:18292600, ECO:0000269\|PubMed:19033661, ECO:0000269\|PubMed:19903888, ECO:0000269\|PubMed:19948740, ECO:0000269\|PubMed:20080667, ECO:0000269\|PubMed:20154697, ECO:0000269\|PubMed:21700930, ECO:0000269\|PubMed:22696229, ECO:0000269\|PubMed:29156729}.
Q5VZ89	DENND4C	S1659	ochoa	DENN domain-containing protein 4C	Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269\|PubMed:20937701}.
Q63HR2	TNS2	S102	ochoa	Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)	Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856). Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354). In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354). Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354). Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049). Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049). Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572). {ECO:0000250\|UniProtKB:Q8CGB6, ECO:0000269\|PubMed:15817639, ECO:0000269\|PubMed:20069572, ECO:0000269\|PubMed:23401856, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:28955049, ECO:0000269\|PubMed:30092354}.
Q63ZY3	KANK2	S155	ochoa	KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)	Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250\|UniProtKB:Q8BX02, ECO:0000269\|PubMed:17476305, ECO:0000269\|PubMed:17996375, ECO:0000269\|PubMed:22371500, ECO:0000269\|PubMed:24671081, ECO:0000269\|PubMed:25961457}.
Q68DK2	ZFYVE26	S1742	ochoa	Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)	Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269\|PubMed:20208530}.
Q6DN14	MCTP1	S95	ochoa	Multiple C2 and transmembrane domain-containing protein 1	Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250\|UniProtKB:A1ZBD6}.
Q6FI81	CIAPIN1	S215	ochoa	Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)	Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250\|UniProtKB:P36152, ECO:0000250\|UniProtKB:Q8WTY4, ECO:0000255\|HAMAP-Rule:MF_03115, ECO:0000269\|PubMed:23596212}.
Q6IQ22	RAB12	S218	ochoa	Ras-related protein Rab-12 (EC 3.6.5.2)	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250\|UniProtKB:P35283, ECO:0000250\|UniProtKB:P61026}.
Q6IQ23	PLEKHA7	S554	ochoa	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011). {ECO:0000269\|PubMed:19041755, ECO:0000269\|PubMed:30463011}.
Q6N021	TET2	S402	ochoa	Methylcytosine dioxygenase TET2 (EC 1.14.11.80)	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269\|PubMed:19483684, ECO:0000269\|PubMed:21057493, ECO:0000269\|PubMed:21817016, ECO:0000269\|PubMed:23222540, ECO:0000269\|PubMed:23353889, ECO:0000269\|PubMed:24315485, ECO:0000269\|PubMed:32518946}.
Q6NZ67	MZT2B	S139	ochoa	Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B)	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269\|PubMed:20360068, ECO:0000269\|PubMed:39321809}.
Q6P0Q8	MAST2	S148	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P0Q8	MAST2	S230	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P1R3	MSANTD2	S27	ochoa	Myb/SANT-like DNA-binding domain-containing protein 2	None
Q6P582	MZT2A	S139	ochoa	Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A)	Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809). {ECO:0000269\|PubMed:20360068, ECO:0000269\|PubMed:39321809}.
Q6PKG0	LARP1	S761	ochoa	La-related protein 1 (La ribonucleoprotein domain family member 1)	RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:23711370, ECO:0000269\|PubMed:24532714, ECO:0000269\|PubMed:25940091, ECO:0000269\|PubMed:26206669, ECO:0000269\|PubMed:28379136, ECO:0000269\|PubMed:28650797, ECO:0000269\|PubMed:28673543, ECO:0000269\|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269\|PubMed:26735137}.
Q6R327	RICTOR	S1292	ochoa	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)	Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470, PubMed:19720745, PubMed:19995915, PubMed:21343617, PubMed:33158864, PubMed:35904232, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:19720745, PubMed:19935711, PubMed:19995915). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718, PubMed:21343617). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (PubMed:21343617, PubMed:33158864, PubMed:35926713). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (PubMed:33158864). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:19720745, PubMed:19935711, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). {ECO:0000250\|UniProtKB:Q6QI06, ECO:0000269\|PubMed:15268862, ECO:0000269\|PubMed:15467718, ECO:0000269\|PubMed:15718470, ECO:0000269\|PubMed:19720745, ECO:0000269\|PubMed:19935711, ECO:0000269\|PubMed:19995915, ECO:0000269\|PubMed:21343617, ECO:0000269\|PubMed:33158864, ECO:0000269\|PubMed:35904232, ECO:0000269\|PubMed:35926713}.
Q6UUV7	CRTC3	S375	ochoa	CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:14506290, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:15466468, ECO:0000269\|PubMed:16817901, ECO:0000269\|PubMed:16980408, ECO:0000269\|PubMed:17210223, ECO:0000269\|PubMed:17644518}.
Q6UUV9	CRTC1	S151	ochoa\|psp	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250\|UniProtKB:Q157S1, ECO:0000250\|UniProtKB:Q68ED7, ECO:0000269\|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:16809310}.
Q6UUV9	CRTC1	S245	ochoa	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250\|UniProtKB:Q157S1, ECO:0000250\|UniProtKB:Q68ED7, ECO:0000269\|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269\|PubMed:16809310}.
Q6UXY1	BAIAP2L2	S429	ochoa	BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar)	Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.
Q6ZNJ1	NBEAL2	S1836	ochoa	Neurobeachin-like protein 2	Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269\|PubMed:21765411, ECO:0000269\|PubMed:21765412}.
Q6ZVL6	KIAA1549L	S1581	ochoa	UPF0606 protein KIAA1549L	None
Q76I76	SSH2	S38	ochoa	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250\|UniProtKB:Q5SW75, ECO:0000269\|PubMed:11832213}.
Q76L83	ASXL2	S517	ochoa	Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BZ32, ECO:0000269\|PubMed:21047783, ECO:0000269\|PubMed:30664650, ECO:0000269\|PubMed:36180891}.
Q7L591	DOK3	S330	ochoa	Docking protein 3 (Downstream of tyrosine kinase 3)	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
Q7L9B9	EEPD1	S110	ochoa	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	None
Q7L9B9	EEPD1	S220	ochoa	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	None
Q7Z2K8	GPRIN1	S341	ochoa	G protein-regulated inducer of neurite outgrowth 1 (GRIN1)	May be involved in neurite outgrowth. {ECO:0000250}.
Q7Z3G6	PRICKLE2	S753	ochoa	Prickle-like protein 2	None
Q7Z3T8	ZFYVE16	S946	ochoa	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein)	May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269\|PubMed:11546807, ECO:0000269\|PubMed:14613930}.
Q7Z403	TMC6	S112	ochoa	Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4)	Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). {ECO:0000250\|UniProtKB:Q7TN60, ECO:0000269\|PubMed:18158319, ECO:0000269\|PubMed:30068544, ECO:0000269\|PubMed:32917726}.
Q7Z591	AKNA	S534	ochoa	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250\|UniProtKB:Q80VW7, ECO:0000269\|PubMed:11268217, ECO:0000305}.
Q7Z591	AKNA	S886	ochoa	Microtubule organization protein AKNA (AT-hook-containing transcription factor)	Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250\|UniProtKB:Q80VW7, ECO:0000269\|PubMed:11268217, ECO:0000305}.
Q7Z6I6	ARHGAP30	S240	ochoa	Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)	GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269\|PubMed:21565175}.
Q7Z6I6	ARHGAP30	S327	ochoa\|psp	Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)	GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269\|PubMed:21565175}.
Q7Z6I6	ARHGAP30	S1064	ochoa	Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)	GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269\|PubMed:21565175}.
Q86SQ0	PHLDB2	S58	ochoa	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269\|PubMed:12376540}.
Q86TC9	MYPN	S198	ochoa	Myopalladin (145 kDa sarcomeric protein)	Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. {ECO:0000269\|PubMed:11309420}.
Q86UD0	SAPCD2	S157	ochoa	Suppressor APC domain-containing protein 2 (Tumor specificity and mitosis phase-dependent expression protein) (TS/MDEP) (p42.3)	Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). {ECO:0000250\|UniProtKB:Q9D818, ECO:0000269\|PubMed:23576022, ECO:0000269\|PubMed:23704824, ECO:0000269\|PubMed:26766442}.
Q86UW9	DTX2	S217	ochoa	Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Q86UY5	FAM83A	S113	ochoa	Protein FAM83A (Tumor antigen BJ-TSA-9) (Tumor-specific gene expressed in prostate protein)	Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250\|UniProtKB:Q8K2P2}.
Q86YV0	RASAL3	S236	ochoa	RAS protein activator like-3	Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway. {ECO:0000250\|UniProtKB:Q8C2K5}.
Q86YW5	TREML1	S264	ochoa	Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)	Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269\|PubMed:15128762}.
Q8IUC4	RHPN2	S652	ochoa	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269\|PubMed:12221077}.
Q8IUC6	TICAM1	S199	ochoa	TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)	Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250\|UniProtKB:Q80UF7, ECO:0000269\|PubMed:12471095, ECO:0000269\|PubMed:12539043, ECO:0000269\|PubMed:14739303, ECO:0000269\|PubMed:25636800, ECO:0000269\|PubMed:35215908}.
Q8IWQ3	BRSK2	S382	ochoa	Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)	Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:20026642, ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:22669945, ECO:0000269\|PubMed:22798068, ECO:0000269\|PubMed:23029325}.
Q8IX90	SKA3	S159	ochoa	Spindle and kinetochore-associated protein 3	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269\|PubMed:19289083, ECO:0000269\|PubMed:19360002, ECO:0000269\|PubMed:23085020}.
Q8IYM2	SLFN12	S368	psp	Ribonuclease SLFN12 (EC 3.1.-.-) (Schlafen family member 12)	Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34272366, PubMed:34707099, PubMed:35104454). May play a role in cell differentiation (PubMed:30045019). {ECO:0000269\|PubMed:30045019, ECO:0000269\|PubMed:31420216, ECO:0000269\|PubMed:34272366, ECO:0000269\|PubMed:34707099, ECO:0000269\|PubMed:35104454}.
Q8IYT8	ULK2	S516	ochoa	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269\|PubMed:18936157, ECO:0000269\|PubMed:21460634, ECO:0000269\|PubMed:21460635, ECO:0000269\|PubMed:21690395, ECO:0000269\|PubMed:21795849}.
Q8IZQ8	MYOCD	S158	ochoa	Myocardin	Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q8R5I7, ECO:0000269\|PubMed:12640126, ECO:0000269\|PubMed:31513549}.
Q8N163	CCAR2	S23	ochoa	Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)	Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269\|PubMed:18235501, ECO:0000269\|PubMed:18235502, ECO:0000269\|PubMed:19131338, ECO:0000269\|PubMed:19218236, ECO:0000269\|PubMed:20074560, ECO:0000269\|PubMed:20160719, ECO:0000269\|PubMed:21030595, ECO:0000269\|PubMed:22446626, ECO:0000269\|PubMed:23352644, ECO:0000269\|PubMed:23398316, ECO:0000269\|PubMed:24415752, ECO:0000269\|PubMed:24824780, ECO:0000269\|PubMed:25361978, ECO:0000269\|PubMed:25661920, ECO:0000269\|PubMed:25732823}.
Q8N9T8	KRI1	S217	ochoa	Protein KRI1 homolog	None
Q8ND25	ZNRF1	S120	ochoa	E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)	E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation (PubMed:28593998, PubMed:33996800, PubMed:37158982). Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation (PubMed:22797923). Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery (PubMed:33996800). Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production (PubMed:37158982). Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response (PubMed:28593998). {ECO:0000269\|PubMed:22797923, ECO:0000269\|PubMed:28593998, ECO:0000269\|PubMed:29626159, ECO:0000269\|PubMed:33996800, ECO:0000269\|PubMed:37158982, ECO:0000305\|PubMed:14561866}.
Q8NE86	MCU	S57	psp	Calcium uniporter protein, mitochondrial (HsMCU) (Coiled-coil domain-containing protein 109A)	Channel-forming and calcium-conducting subunit of the mitochondrial inner membrane calcium uniporter complex (uniplex), which mediates calcium uptake into the mitochondrial matrix (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:29995857, PubMed:30454562, PubMed:30638448, PubMed:31080062, PubMed:32494073, PubMed:32762847, PubMed:33296646, PubMed:37036971, PubMed:37126688). MCU channel activity is regulated by the calcium-sensor subunits of the uniplex MICU1 and MICU2 (or MICU3) (PubMed:24560927, PubMed:26903221, PubMed:30454562, PubMed:30638448, PubMed:32494073, PubMed:32762847, PubMed:37036971, PubMed:37126688). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (PubMed:21685886, PubMed:21685888, PubMed:22822213, PubMed:22829870, PubMed:22904319, PubMed:23101630, PubMed:23178883, PubMed:23755363, PubMed:24332854, PubMed:24560927, PubMed:26341627, PubMed:29954988, PubMed:32494073, PubMed:32762847). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22829870, PubMed:22904319). Involved in antigen processing and presentation (By similarity). {ECO:0000250\|UniProtKB:Q3UMR5, ECO:0000269\|PubMed:21685886, ECO:0000269\|PubMed:21685888, ECO:0000269\|PubMed:22822213, ECO:0000269\|PubMed:22829870, ECO:0000269\|PubMed:22904319, ECO:0000269\|PubMed:23101630, ECO:0000269\|PubMed:23178883, ECO:0000269\|PubMed:23755363, ECO:0000269\|PubMed:24332854, ECO:0000269\|PubMed:24560927, ECO:0000269\|PubMed:25603276, ECO:0000269\|PubMed:26341627, ECO:0000269\|PubMed:26903221, ECO:0000269\|PubMed:29954988, ECO:0000269\|PubMed:29995857, ECO:0000269\|PubMed:30454562, ECO:0000269\|PubMed:30638448, ECO:0000269\|PubMed:31080062, ECO:0000269\|PubMed:32494073, ECO:0000269\|PubMed:32762847, ECO:0000269\|PubMed:33296646, ECO:0000269\|PubMed:37036971, ECO:0000269\|PubMed:37126688}.
Q8NFP9	NBEA	S1714	ochoa	Neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B)	Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}.
Q8TAQ2	SMARCC2	S555	ochoa	SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250\|UniProtKB:Q6PDG5, ECO:0000269\|PubMed:10078207, ECO:0000269\|PubMed:11018012, ECO:0000269\|PubMed:12192000, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
Q8TBC3	SHKBP1	S637	ochoa	SH3KBP1-binding protein 1 (SETA-binding protein 1)	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250\|UniProtKB:Q6P7W2}.
Q8TDM6	DLG5	S1263	ochoa	Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)	Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250\|UniProtKB:E9Q9R9, ECO:0000269\|PubMed:28087714, ECO:0000269\|PubMed:28169360}.
Q8TE68	EPS8L1	S118	ochoa	Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269\|PubMed:14565974}.
Q8TEH3	DENND1A	S592	ochoa	DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250\|UniProtKB:Q8K382, ECO:0000269\|PubMed:20154091, ECO:0000269\|PubMed:20937701}.
Q8TF72	SHROOM3	S1135	ochoa	Protein Shroom3 (Shroom-related protein) (hShrmL)	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250\|UniProtKB:Q27IV2, ECO:0000250\|UniProtKB:Q9QXN0}.
Q8TF72	SHROOM3	S1221	ochoa	Protein Shroom3 (Shroom-related protein) (hShrmL)	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250\|UniProtKB:Q27IV2, ECO:0000250\|UniProtKB:Q9QXN0}.
Q8WVF1	OSCP1	S274	ochoa	Protein OSCP1 (hOSCP1) (Organic solute transport protein 1) (Oxidored-nitro domain-containing protein 1)	May be involved in drug clearance in the placenta. {ECO:0000269\|PubMed:16006562}.
Q8WXD9	CASKIN1	S706	ochoa	Caskin-1 (CASK-interacting protein 1)	May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WXD9	CASKIN1	S724	ochoa	Caskin-1 (CASK-interacting protein 1)	May link the scaffolding protein CASK to downstream intracellular effectors. {ECO:0000250}.
Q8WZ74	CTTNBP2	S361	ochoa	Cortactin-binding protein 2 (CortBP2)	Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons. {ECO:0000250\|UniProtKB:Q2IBD4}.
Q92667	AKAP1	S107	ochoa	A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)	Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity). {ECO:0000250\|UniProtKB:O08715, ECO:0000269\|PubMed:31522117}.
Q96EK9	KTI12	S205	ochoa	Protein KTI12 homolog	None
Q96HS1	PGAM5	S171	ochoa	Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5)	Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269\|PubMed:18387606, ECO:0000269\|PubMed:19590015, ECO:0000269\|PubMed:22265414, ECO:0000269\|PubMed:24746696, ECO:0000269\|PubMed:32439975, ECO:0000269\|PubMed:37498743}.
Q96JB2	COG3	S533	ochoa	Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)	Involved in ER-Golgi transport (PubMed:11929878). Also involved in retrograde (Golgi to ER) transport (PubMed:37711075). {ECO:0000269\|PubMed:11929878, ECO:0000269\|PubMed:37711075}.
Q96JM7	L3MBTL3	S670	ochoa	Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)	Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250\|UniProtKB:Q8BLB7, ECO:0000269\|PubMed:29030483, ECO:0000269\|PubMed:29691401, ECO:0000269\|PubMed:30442713}.
Q96JT2	SLC45A3	S423	ochoa	Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein)	Proton-associated sucrose transporter. May be able to transport also glucose and fructose. {ECO:0000250\|UniProtKB:Q8K0H7}.
Q96N21	TEPSIN	S351	ochoa	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)	Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305\|PubMed:22472443, ECO:0000305\|PubMed:26542808}.
Q96PE2	ARHGEF17	S568	ochoa	Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)	Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269\|PubMed:12071859}.
Q96PE2	ARHGEF17	S862	ochoa	Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)	Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. {ECO:0000269\|PubMed:12071859}.
Q96PU5	NEDD4L	S538	ochoa	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250\|UniProtKB:Q8CFI0, ECO:0000269\|PubMed:12911626, ECO:0000269\|PubMed:15040001, ECO:0000269\|PubMed:15217910, ECO:0000269\|PubMed:15489223, ECO:0000269\|PubMed:15496141, ECO:0000269\|PubMed:15576372, ECO:0000269\|PubMed:18577513, ECO:0000269\|PubMed:19144635, ECO:0000269\|PubMed:23999003, ECO:0000269\|PubMed:25631046, ECO:0000269\|PubMed:26363003, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27694961, ECO:0000269\|PubMed:33608556}.
Q96Q45	TMEM237	S104	ochoa	Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein)	Component of the transition zone in primary cilia. Required for ciliogenesis. {ECO:0000269\|PubMed:22152675}.
Q96QR8	PURB	S101	ochoa	Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B)	Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250\|UniProtKB:O35295, ECO:0000250\|UniProtKB:Q68A21, ECO:0000269\|PubMed:1448097}.
Q96QT4	TRPM7	S1533	ochoa\|psp	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]	Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250\|UniProtKB:Q923J1, ECO:0000269\|PubMed:11385574, ECO:0000269\|PubMed:12887921, ECO:0000269\|PubMed:15485879, ECO:0000269\|PubMed:18365021, ECO:0000269\|PubMed:18394644, ECO:0000269\|PubMed:24316671, ECO:0000269\|PubMed:35561741, ECO:0000269\|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250\|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250\|UniProtKB:Q923J1}.
Q96RT1	ERBIN	S1179	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96RT1	ERBIN	S1271	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96T58	SPEN	S727	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q99569	PKP4	S314	ochoa	Plakophilin-4 (p0071)	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269\|PubMed:17115030}.
Q99618	CDCA3	S31	ochoa	Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1)	F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). {ECO:0000250}.
Q99816	TSG101	S48	ochoa	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269\|PubMed:11916981, ECO:0000269\|PubMed:17556548, ECO:0000269\|PubMed:17853893, ECO:0000269\|PubMed:21070952, ECO:0000269\|PubMed:21757351, ECO:0000269\|PubMed:22315426, ECO:0000269\|PubMed:22660413}.
Q99988	GDF15	S97	ochoa	Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)	Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite (PubMed:23468844, PubMed:24971956, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:29046435, PubMed:30639358, PubMed:31875646, PubMed:33589633, PubMed:38092039). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:30639358, PubMed:33589633, PubMed:38092039). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:31535977). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:28953886). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:31402172). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). In addition to suppress appetite, also promotes weight loss by enhancing energy expenditure in muscle: acts by increasing calcium futile cycling in muscle (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:31875646, PubMed:37060902). The contribution of GDF15 to weight loss following metformin treatment is however limited and subject to discussion (PubMed:36001956). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea, vomiting and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (PubMed:32661391). Responsible for the risk of nausea and vomiting during pregnancy: high levels of GDF15 during pregnancy, mostly originating from the fetus, are associated with increased nausea and vomiting (PubMed:38092039). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, women with naturally high level of GDF15 being less susceptible to nausea than women with low levels of GDF15 before pregnancy (PubMed:38092039). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (PubMed:31402172). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity). {ECO:0000250\|UniProtKB:Q9Z0J7, ECO:0000269\|PubMed:23468844, ECO:0000269\|PubMed:24971956, ECO:0000269\|PubMed:28846097, ECO:0000269\|PubMed:28846098, ECO:0000269\|PubMed:28846099, ECO:0000269\|PubMed:28953886, ECO:0000269\|PubMed:29046435, ECO:0000269\|PubMed:30639358, ECO:0000269\|PubMed:31402172, ECO:0000269\|PubMed:31535977, ECO:0000269\|PubMed:31875646, ECO:0000269\|PubMed:32661391, ECO:0000269\|PubMed:33589633, ECO:0000269\|PubMed:36001956, ECO:0000269\|PubMed:37060902, ECO:0000269\|PubMed:38092039}.
Q9BPU6	DPYSL5	S531	ochoa	Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)	Involved in the negative regulation of dendrite outgrowth. {ECO:0000269\|PubMed:33894126}.
Q9BQK8	LPIN3	S463	ochoa	Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)	Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250\|UniProtKB:Q99PI4}.
Q9BRK0	REEP2	S150	ochoa\|psp	Receptor expression-enhancing protein 2	Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269\|PubMed:24388663}.
Q9BTE3	MCMBP	S223	ochoa	Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)	Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269\|PubMed:20090939, ECO:0000269\|PubMed:21196493}.
Q9BVV6	KIAA0586	S1129	ochoa	Protein TALPID3	Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). {ECO:0000250\|UniProtKB:E9PV87, ECO:0000250\|UniProtKB:Q1G7G9, ECO:0000269\|PubMed:24421332}.
Q9BXB5	OSBPL10	S188	ochoa	Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)	Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:19554302, ECO:0000269\|PubMed:22906437, ECO:0000269\|PubMed:23934110, ECO:0000305}.
Q9BXP2	SLC12A9	S658	ochoa	Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3)	May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (PubMed:10871601). May play a role in lysosomal ion flux and osmoregulation (PubMed:38334070). {ECO:0000269\|PubMed:10871601, ECO:0000269\|PubMed:38334070}.
Q9BY89	KIAA1671	S1602	ochoa	Uncharacterized protein KIAA1671	None
Q9BYB0	SHANK3	S375	ochoa	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269\|PubMed:24132240}.
Q9BYW2	SETD2	S800	ochoa	Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)	Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250\|UniProtKB:E9Q5F9, ECO:0000269\|PubMed:16118227, ECO:0000269\|PubMed:19141475, ECO:0000269\|PubMed:21526191, ECO:0000269\|PubMed:21792193, ECO:0000269\|PubMed:23043551, ECO:0000269\|PubMed:23325844, ECO:0000269\|PubMed:23622243, ECO:0000269\|PubMed:24509477, ECO:0000269\|PubMed:24843002, ECO:0000269\|PubMed:27317772, ECO:0000269\|PubMed:27474439, ECO:0000269\|PubMed:27518565, ECO:0000269\|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269\|PubMed:11461154}.
Q9BZ72	PITPNM2	S400	ochoa	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269\|PubMed:10022914}.
Q9BZ72	PITPNM2	S867	ochoa	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269\|PubMed:10022914}.
Q9BZ72	PITPNM2	S872	ochoa	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. {ECO:0000269\|PubMed:10022914}.
Q9BZF3	OSBPL6	S344	ochoa	Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)	Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250\|UniProtKB:Q8BXR9, ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:26941018}.
Q9C0B9	ZCCHC2	S804	ochoa	Zinc finger CCHC domain-containing protein 2	None
Q9C0C2	TNKS1BP1	S724	ochoa	182 kDa tankyrase-1-binding protein	None
Q9C0D0	PHACTR1	S185	ochoa	Phosphatase and actin regulator 1	Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250\|UniProtKB:Q2M3X8, ECO:0000269\|PubMed:21798305, ECO:0000269\|PubMed:21939755}.
Q9C0D0	PHACTR1	S187	ochoa	Phosphatase and actin regulator 1	Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (PubMed:21798305, PubMed:21939755). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). {ECO:0000250\|UniProtKB:Q2M3X8, ECO:0000269\|PubMed:21798305, ECO:0000269\|PubMed:21939755}.
Q9H0F6	SHARPIN	S131	ochoa\|psp	Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)	Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). {ECO:0000269\|PubMed:21455173, ECO:0000269\|PubMed:21455180, ECO:0000269\|PubMed:21455181, ECO:0000269\|PubMed:23708998, ECO:0000269\|PubMed:28481331}.
Q9H171	ZBP1	S27	ochoa	Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1)	Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (By similarity). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (By similarity). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (By similarity). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). {ECO:0000250\|UniProtKB:Q9QY24, ECO:0000269\|PubMed:32200799}.; FUNCTION: (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion. {ECO:0000269\|PubMed:33348174}.
Q9H1Z4	WDR13	S86	ochoa	WD repeat-containing protein 13	None
Q9H201	EPN3	S503	ochoa	Epsin-3 (EPS-15-interacting protein 3)	None
Q9H3K6	BOLA2	S34	ochoa	BolA-like protein 2	Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269\|PubMed:26613676, ECO:0000269\|PubMed:27519415}.
Q9H3T2	SEMA6C	S650	ochoa	Semaphorin-6C (Semaphorin-Y) (Sema Y)	Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. {ECO:0000269\|PubMed:12110693}.
Q9H3T3	SEMA6B	S749	ochoa	Semaphorin-6B (Semaphorin-Z) (Sema Z)	Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. {ECO:0000250\|UniProtKB:O54951}.; FUNCTION: (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. {ECO:0000269\|PubMed:32302524, ECO:0000269\|PubMed:32589945}.
Q9H3Z4	DNAJC5	S34	psp	DnaJ homolog subfamily C member 5 (Ceroid-lipofuscinosis neuronal protein 4) (Cysteine string protein) (CSP)	Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). {ECO:0000250\|UniProtKB:P60904, ECO:0000250\|UniProtKB:Q29455}.
Q9H5J8	TAF1D	S27	ochoa	TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D)	Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269\|PubMed:15970593, ECO:0000269\|PubMed:17318177}.
Q9H7P9	PLEKHG2	S437	ochoa	Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)	May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250\|UniProtKB:Q6KAU7, ECO:0000269\|PubMed:18045877, ECO:0000269\|PubMed:26573021}.
Q9HAU0	PLEKHA5	S382	ochoa	Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)	None
Q9HAW4	CLSPN	S774	ochoa	Claspin (hClaspin)	Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation (PubMed:12766152, PubMed:15190204, PubMed:15707391, PubMed:16123041). Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins (PubMed:12766152, PubMed:15096610, PubMed:15707391, PubMed:16123041). Also required to maintain normal rates of replication fork progression during unperturbed DNA replication. Binds directly to DNA, with particular affinity for branched or forked molecules and interacts with multiple protein components of the replisome such as the MCM2-7 complex and TIMELESS (PubMed:15226314, PubMed:34694004, PubMed:35585232). Important for initiation of DNA replication, recruits kinase CDC7 to phosphorylate MCM2-7 components (PubMed:27401717). {ECO:0000269\|PubMed:12766152, ECO:0000269\|PubMed:15096610, ECO:0000269\|PubMed:15190204, ECO:0000269\|PubMed:15226314, ECO:0000269\|PubMed:15707391, ECO:0000269\|PubMed:16123041, ECO:0000269\|PubMed:27401717, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:35585232}.
Q9HCJ0	TNRC6C	S714	ochoa	Trinucleotide repeat-containing gene 6C protein	Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269\|PubMed:19304925, ECO:0000269\|PubMed:21981923, ECO:0000269\|PubMed:21984184, ECO:0000269\|PubMed:21984185}.
Q9HCK8	CHD8	S1995	ochoa	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255\|HAMAP-Rule:MF_03071, ECO:0000269\|PubMed:17938208, ECO:0000269\|PubMed:18378692, ECO:0000269\|PubMed:28533432, ECO:0000269\|PubMed:36537238}.
Q9HCM7	FBRSL1	S937	ochoa	Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9)	None
Q9NPI6	DCP1A	S364	ochoa	mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269\|PubMed:11836524, ECO:0000269\|PubMed:12417715, ECO:0000269\|PubMed:33813271}.
Q9NQV6	PRDM10	S803	ochoa	PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin)	Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (By similarity). Activates the transcription of FLNC (PubMed:36440963). {ECO:0000250\|UniProtKB:Q3UTQ7, ECO:0000269\|PubMed:36440963}.
Q9NRM7	LATS2	S446	psp	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269\|PubMed:10871863, ECO:0000269\|PubMed:12853976, ECO:0000269\|PubMed:15131260, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:21952048, ECO:0000269\|PubMed:26437443, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:34404733, ECO:0000269\|PubMed:39173637}.
Q9NVA4	TMEM184C	S417	ochoa	Transmembrane protein 184C (Transmembrane protein 34)	Possible tumor suppressor which may play a role in cell growth. {ECO:0000269\|PubMed:17072649}.
Q9NYL2	MAP3K20	S733	ochoa	Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)	Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269\|PubMed:10924358, ECO:0000269\|PubMed:11042189, ECO:0000269\|PubMed:11836244, ECO:0000269\|PubMed:12220515, ECO:0000269\|PubMed:14521931, ECO:0000269\|PubMed:15172994, ECO:0000269\|PubMed:15342622, ECO:0000269\|PubMed:15350844, ECO:0000269\|PubMed:15737997, ECO:0000269\|PubMed:18331592, ECO:0000269\|PubMed:20559024, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:26999302, ECO:0000269\|PubMed:27859413, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269\|PubMed:15684425, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269\|PubMed:27859413, ECO:0000269\|PubMed:32289254, ECO:0000269\|PubMed:32610081, ECO:0000269\|PubMed:35857590}.
Q9NZL6	RGL1	S520	ochoa	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)	Probable guanine nucleotide exchange factor.
Q9NZQ3	NCKIPSD	S150	ochoa	NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)	Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269\|PubMed:22419821}.
Q9P0V3	SH3BP4	S246	ochoa\|psp	SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)	May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269\|PubMed:16325581, ECO:0000269\|PubMed:22575674}.
Q9P107	GMIP	S885	ochoa	GEM-interacting protein (GMIP)	Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269\|PubMed:12093360}.
Q9P206	NHSL3	S314	ochoa	NHS-like protein 3	Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269\|PubMed:32854746}.
Q9P219	CCDC88C	S1547	ochoa	Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)	Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). {ECO:0000269\|PubMed:26126266, ECO:0000269\|PubMed:30948426}.
Q9P227	ARHGAP23	S316	ochoa	Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9P241	ATP10D	S520	ochoa	Phospholipid-transporting ATPase VD (EC 7.6.2.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D)	Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane. {ECO:0000269\|PubMed:30530492}.
Q9P275	USP36	S429	ochoa	Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)	Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269\|PubMed:19208757, ECO:0000269\|PubMed:21268071, ECO:0000269\|PubMed:22622177, ECO:0000269\|PubMed:22902402, ECO:0000269\|PubMed:25775507, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:29273634, ECO:0000269\|PubMed:29274341, ECO:0000269\|PubMed:35989368, ECO:0000269\|PubMed:36912080}.
Q9UBL3	ASH2L	S321	ochoa	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:19131338, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:22266653}.
Q9UJY1	HSPB8	S27	psp	Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)	Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity. {ECO:0000250\|UniProtKB:Q9JK92}.
Q9UKE5	TNIK	S707	ochoa	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269\|PubMed:10521462, ECO:0000269\|PubMed:15342639, ECO:0000269\|PubMed:19061864, ECO:0000269\|PubMed:19816403, ECO:0000269\|PubMed:20159449, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.
Q9ULC8	ZDHHC8	S642	ochoa	Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250\|UniProtKB:Q5Y5T5, ECO:0000305\|PubMed:19556522, ECO:0000305\|PubMed:23034182, ECO:0000305\|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269\|PubMed:34599882}.
Q9ULH0	KIDINS220	S1329	ochoa	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269\|PubMed:18089783}.
Q9ULH0	KIDINS220	S1654	ochoa	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269\|PubMed:18089783}.
Q9ULI3	HEG1	S1319	ochoa	Protein HEG homolog 1	Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Q9UN79	SOX13	S309	ochoa	Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12)	Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250\|UniProtKB:Q04891, ECO:0000269\|PubMed:10871192, ECO:0000269\|PubMed:20028982}.
Q9UPA5	BSN	S2041	ochoa	Protein bassoon (Zinc finger protein 231)	Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250\|UniProtKB:O35078, ECO:0000250\|UniProtKB:O88778, ECO:0000269\|PubMed:12812759, ECO:0000269\|PubMed:19380881}.
Q9UPN3	MACF1	S7279	ochoa	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)	[Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250\|UniProtKB:Q9QXZ0, ECO:0000269\|PubMed:15265687, ECO:0000269\|PubMed:20937854, ECO:0000269\|PubMed:27693509}.
Q9UPT8	ZC3H4	S840	ochoa	Zinc finger CCCH domain-containing protein 4	RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269\|PubMed:33767452, ECO:0000269\|PubMed:33913806}.
Q9UQ35	SRRM2	S2200	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQB8	BAIAP2	S454	ochoa\|psp	BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)	Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269\|PubMed:11130076, ECO:0000269\|PubMed:11696321, ECO:0000269\|PubMed:14752106, ECO:0000269\|PubMed:17115031, ECO:0000269\|PubMed:19366662}.
Q9Y294	ASF1A	S166	ochoa\|psp	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)	Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198). Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 (PubMed:29478807). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:21454524, PubMed:29408485). Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit (PubMed:15621527). {ECO:0000269\|PubMed:10759893, ECO:0000269\|PubMed:11897662, ECO:0000269\|PubMed:12842904, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527, ECO:0000269\|PubMed:15664198, ECO:0000269\|PubMed:16151251, ECO:0000269\|PubMed:21454524, ECO:0000269\|PubMed:29408485, ECO:0000269\|PubMed:29478807}.
Q9Y2H0	DLGAP4	S768	ochoa	Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Q9Y2H5	PLEKHA6	S443	ochoa	Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)	None
Q9Y2W2	WBP11	S181	ochoa	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269\|PubMed:10593949, ECO:0000269\|PubMed:11375989, ECO:0000269\|PubMed:14640981}.
Q9Y3M8	STARD13	S389	ochoa	StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)	GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269\|PubMed:14697242, ECO:0000269\|PubMed:16217026}.
Q9Y3M8	STARD13	S470	ochoa	StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)	GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269\|PubMed:14697242, ECO:0000269\|PubMed:16217026}.
Q9Y450	HBS1L	S205	ochoa	HBS1-like protein (EC 3.6.5.-) (ERFS)	GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). {ECO:0000269\|PubMed:21448132, ECO:0000269\|PubMed:23667253, ECO:0000269\|PubMed:27863242, ECO:0000269\|PubMed:32006463}.
Q9Y4C1	KDM3A	S766	ochoa	Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A)	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269\|PubMed:16603237, ECO:0000269\|PubMed:28262558}.
Q9Y4H2	IRS2	S894	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y6J0	CABIN1	S1473	ochoa	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:9655484}.
Q9Y6J0	CABIN1	S1798	ochoa	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:9655484}.
Q9Y6M5	SLC30A1	S466	ochoa	Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)	Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250\|UniProtKB:Q62720, ECO:0000269\|PubMed:18158319, ECO:0000269\|PubMed:31471319, ECO:0000269\|PubMed:32441444}.
O75821	EIF3G	S217	Sugiyama	Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255\|HAMAP-Rule:MF_03006, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
P46013	MKI67	S1686	Sugiyama	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
Q5VT52	RPRD2	S1070	Sugiyama	Regulation of nuclear pre-mRNA domain-containing protein 2	None
P50395	GDI2	S45	Sugiyama	Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)	GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269\|PubMed:25860027}.
Q6XQN6	NAPRT	S500	Sugiyama	Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1)	Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269\|PubMed:17604275, ECO:0000269\|PubMed:21742010, ECO:0000269\|PubMed:26042198}.
P28329	CHAT	S464	SIGNOR\|EPSD	Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6)	Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269\|PubMed:17144655}.
Q8NFA2	NOXO1	S159	SIGNOR	NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)	Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269\|PubMed:12657628, ECO:0000269\|PubMed:14617635, ECO:0000269\|PubMed:15326186, ECO:0000269\|PubMed:15824103, ECO:0000269\|PubMed:15949904, ECO:0000269\|PubMed:16329988, ECO:0000269\|PubMed:17126813, ECO:0000269\|PubMed:19755710}.
P31939	ATIC	S202	Sugiyama	Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]	Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269\|PubMed:10985775, ECO:0000269\|PubMed:11948179, ECO:0000269\|PubMed:14756554, ECO:0000269\|PubMed:25687571, ECO:0000269\|PubMed:9378707}.
P13667	PDIA4	S124	Sugiyama	Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)	None
Q9BQK8	LPIN3	S262	Sugiyama	Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)	Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism. {ECO:0000250\|UniProtKB:Q99PI4}.
O60563	CCNT1	S433	Sugiyama	Cyclin-T1 (CycT1) (Cyclin-T)	Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269\|PubMed:16109376, ECO:0000269\|PubMed:16109377, ECO:0000269\|PubMed:29849146, ECO:0000269\|PubMed:30134174, ECO:0000269\|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269\|PubMed:10329125, ECO:0000269\|PubMed:10329126}.
P52333	JAK3	S1031	Sugiyama	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269\|PubMed:11909529, ECO:0000269\|PubMed:20440074, ECO:0000269\|PubMed:7662955, ECO:0000269\|PubMed:8022485}.
Q15569	TESK1	S355	Sugiyama	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1)	Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250\|UniProtKB:O70146, ECO:0000250\|UniProtKB:Q63572, ECO:0000269\|PubMed:15584898, ECO:0000269\|PubMed:25849865}.
P41970	ELK3	S363	SIGNOR\|iPTMNet	ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)	May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Q15165	PON2	S300	Sugiyama	Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)	Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269\|PubMed:11579088, ECO:0000269\|PubMed:15772423}.
Q6FI81	CIAPIN1	S170	Sugiyama	Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)	Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250\|UniProtKB:P36152, ECO:0000250\|UniProtKB:Q8WTY4, ECO:0000255\|HAMAP-Rule:MF_03115, ECO:0000269\|PubMed:23596212}.
Q8TD08	MAPK15	S364	Sugiyama	Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)	Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250\|UniProtKB:Q80Y86, ECO:0000250\|UniProtKB:Q9Z2A6, ECO:0000269\|PubMed:11875070, ECO:0000269\|PubMed:16484222, ECO:0000269\|PubMed:19166846, ECO:0000269\|PubMed:20638370, ECO:0000269\|PubMed:20733054, ECO:0000269\|PubMed:21190936, ECO:0000269\|PubMed:21847093, ECO:0000269\|PubMed:22948227, ECO:0000269\|PubMed:24618899, ECO:0000269\|PubMed:26595526, ECO:0000269\|PubMed:28842414, ECO:0000269\|PubMed:29021280}.
O15371	EIF3D	S324	Sugiyama	Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)	mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269\|PubMed:18599441, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
Q96HP0	DOCK6	S190	Sugiyama	Dedicator of cytokinesis protein 6	Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269\|PubMed:17196961}.
Q9NQU5	PAK6	S189	Sugiyama	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269\|PubMed:14573606, ECO:0000269\|PubMed:20054820}.

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reactome_id	name	p	-log10_p
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	9.686668e-07	6.014
R-HSA-383280	Nuclear Receptor transcription pathway	1.907436e-05	4.720
R-HSA-162582	Signal Transduction	2.590753e-04	3.587
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	5.241756e-04	3.281
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	7.736168e-04	3.111
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	1.555372e-03	2.808
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	3.177293e-03	2.498
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	2.789470e-03	2.554
R-HSA-9029569	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu...	3.050291e-03	2.516
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	2.631846e-03	2.580
R-HSA-416482	G alpha (12/13) signalling events	2.605350e-03	2.584
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	2.355978e-03	2.628
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	3.172842e-03	2.499
R-HSA-193648	NRAGE signals death through JNK	2.625645e-03	2.581
R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	3.363019e-03	2.473
R-HSA-9707616	Heme signaling	4.050861e-03	2.392
R-HSA-73887	Death Receptor Signaling	4.044621e-03	2.393
R-HSA-428540	Activation of RAC1	4.154585e-03	2.381
R-HSA-9022699	MECP2 regulates neuronal receptors and channels	5.029219e-03	2.298
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	5.863969e-03	2.232
R-HSA-8986944	Transcriptional Regulation by MECP2	5.851275e-03	2.233
R-HSA-9764560	Regulation of CDH1 Gene Transcription	6.752211e-03	2.171
R-HSA-9013957	TLR3-mediated TICAM1-dependent programmed cell death	7.359728e-03	2.133
R-HSA-446353	Cell-extracellular matrix interactions	7.938267e-03	2.100
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	8.041056e-03	2.095
R-HSA-111465	Apoptotic cleavage of cellular proteins	9.069669e-03	2.042
R-HSA-193704	p75 NTR receptor-mediated signalling	9.567677e-03	2.019
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	1.039374e-02	1.983
R-HSA-177929	Signaling by EGFR	1.222771e-02	1.913
R-HSA-2028269	Signaling by Hippo	1.176841e-02	1.929
R-HSA-446728	Cell junction organization	1.184875e-02	1.926
R-HSA-9661070	Defective translocation of RB1 mutants to the nucleus	2.089338e-02	1.680
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	2.089338e-02	1.680
R-HSA-5602566	TICAM1 deficiency - HSE	4.135148e-02	1.384
R-HSA-176034	Interactions of Tat with host cellular proteins	6.138335e-02	1.212
R-HSA-4793953	Defective B4GALT1 causes CDG-2d	6.138335e-02	1.212
R-HSA-5602571	TRAF3 deficiency - HSE	6.138335e-02	1.212
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	6.138335e-02	1.212
R-HSA-5619045	Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	6.138335e-02	1.212
R-HSA-5687583	Defective SLC34A2 causes PALM	6.138335e-02	1.212
R-HSA-9665230	Drug resistance in ERBB2 KD mutants	8.099784e-02	1.092
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	8.099784e-02	1.092
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	8.099784e-02	1.092
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	8.099784e-02	1.092
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	8.099784e-02	1.092
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	8.099784e-02	1.092
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	8.099784e-02	1.092
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	8.099784e-02	1.092
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	8.099784e-02	1.092
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	8.099784e-02	1.092
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	8.099784e-02	1.092
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	8.099784e-02	1.092
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	8.099784e-02	1.092
R-HSA-8849473	PTK6 Expression	1.934576e-02	1.713
R-HSA-2562578	TRIF-mediated programmed cell death	1.934576e-02	1.713
R-HSA-8865999	MET activates PTPN11	1.002036e-01	0.999
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	1.002036e-01	0.999
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	1.002036e-01	0.999
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ...	1.190092e-01	0.924
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	3.137647e-02	1.503
R-HSA-8875555	MET activates RAP1 and RAC1	3.137647e-02	1.503
R-HSA-4839744	Signaling by APC mutants	3.589540e-02	1.445
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	3.589540e-02	1.445
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	3.589540e-02	1.445
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	3.589540e-02	1.445
R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	1.374228e-01	0.862
R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	1.374228e-01	0.862
R-HSA-74713	IRS activation	1.374228e-01	0.862
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	1.374228e-01	0.862
R-HSA-9706377	FLT3 signaling by CBL mutants	1.374228e-01	0.862
R-HSA-5339716	Signaling by GSK3beta mutants	4.064821e-02	1.391
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	4.562321e-02	1.341
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	4.562321e-02	1.341
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	4.562321e-02	1.341
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	4.562321e-02	1.341
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	4.562321e-02	1.341
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	4.562321e-02	1.341
R-HSA-9833576	CDH11 homotypic and heterotypic interactions	1.554528e-01	0.808
R-HSA-5603029	IkBA variant leads to EDA-ID	1.554528e-01	0.808
R-HSA-9022537	Loss of MECP2 binding ability to the NCoR/SMRT complex	1.554528e-01	0.808
R-HSA-8939256	RUNX1 regulates transcription of genes involved in WNT signaling	1.731069e-01	0.762
R-HSA-9027283	Erythropoietin activates STAT5	1.731069e-01	0.762
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	1.731069e-01	0.762
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	1.731069e-01	0.762
R-HSA-418885	DCC mediated attractive signaling	6.177020e-02	1.209
R-HSA-9027284	Erythropoietin activates RAS	6.177020e-02	1.209
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	6.177020e-02	1.209
R-HSA-196299	Beta-catenin phosphorylation cascade	6.177020e-02	1.209
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	6.177020e-02	1.209
R-HSA-8851907	MET activates PI3K/AKT signaling	1.903930e-01	0.720
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	1.903930e-01	0.720
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	1.903930e-01	0.720
R-HSA-112412	SOS-mediated signalling	1.903930e-01	0.720
R-HSA-8932506	DAG1 core M1 glycosylations	1.903930e-01	0.720
R-HSA-9726840	SHOC2 M1731 mutant abolishes MRAS complex function	1.903930e-01	0.720
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	3.109328e-02	1.507
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	3.358743e-02	1.474
R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid ce...	2.073189e-01	0.683
R-HSA-8932504	DAG1 core M2 glycosylations	2.073189e-01	0.683
R-HSA-9828211	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	2.073189e-01	0.683
R-HSA-9768778	Regulation of NPAS4 mRNA translation	2.073189e-01	0.683
R-HSA-9028335	Activated NTRK2 signals through PI3K	2.073189e-01	0.683
R-HSA-8875656	MET receptor recycling	2.073189e-01	0.683
R-HSA-9660537	Signaling by MRAS-complex mutants	2.073189e-01	0.683
R-HSA-9726842	Gain-of-function MRAS complexes activate RAF signaling	2.073189e-01	0.683
R-HSA-9006335	Signaling by Erythropoietin	3.887754e-02	1.410
R-HSA-912631	Regulation of signaling by CBL	9.214176e-02	1.036
R-HSA-937041	IKK complex recruitment mediated by RIP1	9.214176e-02	1.036
R-HSA-170984	ARMS-mediated activation	2.238918e-01	0.650
R-HSA-5218900	CASP8 activity is inhibited	2.238918e-01	0.650
R-HSA-5357786	TNFR1-induced proapoptotic signaling	1.052841e-01	0.978
R-HSA-9027277	Erythropoietin activates Phospholipase C gamma (PLCG)	2.401193e-01	0.620
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	2.560085e-01	0.592
R-HSA-9759811	Regulation of CDH11 mRNA translation by microRNAs	2.560085e-01	0.592
R-HSA-8932505	DAG1 core M3 glycosylations	2.560085e-01	0.592
R-HSA-112308	Presynaptic depolarization and calcium channel opening	2.560085e-01	0.592
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	2.715664e-01	0.566
R-HSA-9824878	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	2.715664e-01	0.566
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	2.715664e-01	0.566
R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	3.017157e-01	0.520
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	3.017157e-01	0.520
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	3.017157e-01	0.520
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	3.017157e-01	0.520
R-HSA-9615710	Late endosomal microautophagy	1.693658e-01	0.771
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	3.163205e-01	0.500
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	5.076115e-02	1.294
R-HSA-8948700	Competing endogenous RNAs (ceRNAs) regulate PTEN translation	3.306207e-01	0.481
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	3.306207e-01	0.481
R-HSA-8964315	G beta:gamma signalling through BTK	3.306207e-01	0.481
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	1.995829e-01	0.700
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	3.446226e-01	0.463
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	9.423625e-02	1.026
R-HSA-380287	Centrosome maturation	1.006918e-01	0.997
R-HSA-3371511	HSF1 activation	2.303662e-01	0.638
R-HSA-180292	GAB1 signalosome	3.849003e-01	0.415
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	1.511199e-01	0.821
R-HSA-1989781	PPARA activates gene expression	7.662184e-02	1.116
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	2.176062e-01	0.662
R-HSA-3371571	HSF1-dependent transactivation	3.539960e-01	0.451
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	3.690989e-01	0.433
R-HSA-72649	Translation initiation complex formation	3.765985e-01	0.424
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	3.249075e-01	0.488
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	8.025942e-02	1.096
R-HSA-182971	EGFR downregulation	4.456464e-02	1.351
R-HSA-8878171	Transcriptional regulation by RUNX1	1.676931e-02	1.775
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	3.849003e-01	0.415
R-HSA-8931987	RUNX1 regulates estrogen receptor mediated transcription	1.903930e-01	0.720
R-HSA-9839394	TGFBR3 expression	2.870060e-02	1.542
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	3.428602e-01	0.465
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	3.428602e-01	0.465
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	2.715664e-01	0.566
R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	3.583325e-01	0.446
R-HSA-3371556	Cellular response to heat stress	1.594849e-01	0.797
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	3.428602e-01	0.465
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	3.017157e-01	0.520
R-HSA-195253	Degradation of beta-catenin by the destruction complex	2.286043e-01	0.641
R-HSA-8983432	Interleukin-15 signaling	4.562321e-02	1.341
R-HSA-9020958	Interleukin-21 signaling	2.238918e-01	0.650
R-HSA-9762292	Regulation of CDH11 function	2.401193e-01	0.620
R-HSA-198203	PI3K/AKT activation	2.401193e-01	0.620
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	2.560085e-01	0.592
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	3.077177e-01	0.512
R-HSA-191650	Regulation of gap junction activity	1.190092e-01	0.924
R-HSA-8951936	RUNX3 regulates p14-ARF	4.562321e-02	1.341
R-HSA-9931530	Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	4.562321e-02	1.341
R-HSA-418886	Netrin mediated repulsion signals	1.903930e-01	0.720
R-HSA-8939242	RUNX1 regulates transcription of genes involved in differentiation of keratinocy...	2.073189e-01	0.683
R-HSA-9796292	Formation of axial mesoderm	3.017157e-01	0.520
R-HSA-5673000	RAF activation	2.149229e-01	0.668
R-HSA-451927	Interleukin-2 family signaling	2.614268e-01	0.583
R-HSA-9020558	Interleukin-2 signaling	2.560085e-01	0.592
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	7.839557e-02	1.106
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	2.226339e-01	0.652
R-HSA-4641265	Repression of WNT target genes	2.867999e-01	0.542
R-HSA-5357905	Regulation of TNFR1 signaling	3.157313e-01	0.501
R-HSA-2424491	DAP12 signaling	1.768494e-01	0.752
R-HSA-373752	Netrin-1 signaling	3.002712e-01	0.522
R-HSA-8876384	Listeria monocytogenes entry into host cells	2.015257e-02	1.696
R-HSA-9613829	Chaperone Mediated Autophagy	8.576602e-02	1.067
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	1.374228e-01	0.862
R-HSA-8849472	PTK6 Down-Regulation	1.374228e-01	0.862
R-HSA-426496	Post-transcriptional silencing by small RNAs	1.374228e-01	0.862
R-HSA-5653890	Lactose synthesis	1.731069e-01	0.762
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	2.715664e-01	0.566
R-HSA-9764562	Regulation of CDH1 mRNA translation by microRNAs	3.163205e-01	0.500
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	3.849003e-01	0.415
R-HSA-75893	TNF signaling	1.545541e-01	0.811
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	6.177020e-02	1.209
R-HSA-1266695	Interleukin-7 signaling	2.870060e-02	1.542
R-HSA-8985947	Interleukin-9 signaling	2.073189e-01	0.683
R-HSA-9692913	SARS-CoV-1-mediated effects on programmed cell death	1.190092e-01	0.924
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	5.619495e-02	1.250
R-HSA-8951430	RUNX3 regulates WNT signaling	1.903930e-01	0.720
R-HSA-139853	Elevation of cytosolic Ca2+ levels	7.953193e-02	1.099
R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO	2.238918e-01	0.650
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	2.401193e-01	0.620
R-HSA-399956	CRMPs in Sema3A signaling	3.163205e-01	0.500
R-HSA-77595	Processing of Intronless Pre-mRNAs	3.583325e-01	0.446
R-HSA-9007101	Rab regulation of trafficking	1.462837e-01	0.835
R-HSA-3214815	HDACs deacetylate histones	3.840612e-01	0.416
R-HSA-2428928	IRS-related events triggered by IGF1R	1.801183e-01	0.744
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	8.252192e-02	1.083
R-HSA-4791275	Signaling by WNT in cancer	1.919632e-01	0.717
R-HSA-140534	Caspase activation via Death Receptors in the presence of ligand	6.752464e-02	1.171
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	1.768494e-01	0.752
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	3.163205e-01	0.500
R-HSA-5655302	Signaling by FGFR1 in disease	2.769826e-01	0.558
R-HSA-9759475	Regulation of CDH11 Expression and Function	3.887754e-02	1.410
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	3.109328e-02	1.507
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	1.002036e-01	0.999
R-HSA-427589	Type II Na+/Pi cotransporters	1.002036e-01	0.999
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	1.190092e-01	0.924
R-HSA-8941333	RUNX2 regulates genes involved in differentiation of myeloid cells	1.190092e-01	0.924
R-HSA-4839735	Signaling by AXIN mutants	4.064821e-02	1.391
R-HSA-4839748	Signaling by AMER1 mutants	4.064821e-02	1.391
R-HSA-6807004	Negative regulation of MET activity	1.649381e-02	1.783
R-HSA-3371378	Regulation by c-FLIP	2.073189e-01	0.683
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	8.576602e-02	1.067
R-HSA-418889	Caspase activation via Dependence Receptors in the absence of ligand	2.238918e-01	0.650
R-HSA-2534343	Interaction With Cumulus Cells And The Zona Pellucida	2.238918e-01	0.650
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	1.052841e-01	0.978
R-HSA-9693928	Defective RIPK1-mediated regulated necrosis	2.401193e-01	0.620
R-HSA-209560	NF-kB is activated and signals survival	2.715664e-01	0.566
R-HSA-202670	ERKs are inactivated	2.715664e-01	0.566
R-HSA-5260271	Diseases of Immune System	7.863266e-02	1.104
R-HSA-5602358	Diseases associated with the TLR signaling cascade	7.863266e-02	1.104
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	2.867999e-01	0.542
R-HSA-380615	Serotonin clearance from the synaptic cleft	2.867999e-01	0.542
R-HSA-418890	Role of second messengers in netrin-1 signaling	2.867999e-01	0.542
R-HSA-174490	Membrane binding and targetting of GAG proteins	3.017157e-01	0.520
R-HSA-1227990	Signaling by ERBB2 in Cancer	1.768494e-01	0.752
R-HSA-162588	Budding and maturation of HIV virion	1.843837e-01	0.734
R-HSA-4419969	Depolymerization of the Nuclear Lamina	3.849003e-01	0.415
R-HSA-73980	RNA Polymerase III Transcription Termination	3.849003e-01	0.415
R-HSA-1169091	Activation of NF-kappaB in B cells	3.539960e-01	0.451
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge...	3.706582e-01	0.431
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	5.064082e-02	1.295
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	6.511332e-02	1.186
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	6.466946e-02	1.189
R-HSA-9665348	Signaling by ERBB2 ECD mutants	8.576602e-02	1.067
R-HSA-166166	MyD88-independent TLR4 cascade	4.662355e-02	1.331
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	3.947238e-02	1.404
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	4.662355e-02	1.331
R-HSA-9686347	Microbial modulation of RIPK1-mediated regulated necrosis	1.903930e-01	0.720
R-HSA-74749	Signal attenuation	2.401193e-01	0.620
R-HSA-3295583	TRP channels	1.472755e-01	0.832
R-HSA-1963642	PI3K events in ERBB2 signaling	3.717564e-01	0.430
R-HSA-9843745	Adipogenesis	2.017482e-01	0.695
R-HSA-169893	Prolonged ERK activation events	6.752464e-02	1.171
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	1.619383e-01	0.791
R-HSA-8875878	MET promotes cell motility	2.458782e-01	0.609
R-HSA-5675221	Negative regulation of MAPK pathway	8.649244e-02	1.063
R-HSA-9664565	Signaling by ERBB2 KD Mutants	1.693658e-01	0.771
R-HSA-2428924	IGF1R signaling cascade	1.959716e-01	0.708
R-HSA-139915	Activation of PUMA and translocation to mitochondria	1.903930e-01	0.720
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	2.238918e-01	0.650
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	1.188937e-01	0.925
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	3.163205e-01	0.500
R-HSA-9927020	Heme assimilation	3.583325e-01	0.446
R-HSA-6811438	Intra-Golgi traffic	2.769826e-01	0.558
R-HSA-5658442	Regulation of RAS by GAPs	3.463968e-01	0.460
R-HSA-5673001	RAF/MAP kinase cascade	2.095975e-01	0.679
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	3.155822e-01	0.501
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	2.137796e-02	1.670
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	1.141940e-01	0.942
R-HSA-168898	Toll-like Receptor Cascades	1.592900e-01	0.798
R-HSA-1433559	Regulation of KIT signaling	5.619495e-02	1.250
R-HSA-418360	Platelet calcium homeostasis	1.693658e-01	0.771
R-HSA-6806834	Signaling by MET	4.029805e-02	1.395
R-HSA-6794361	Neurexins and neuroligins	3.954976e-02	1.403
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	2.013306e-01	0.696
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	4.100998e-02	1.387
R-HSA-5684996	MAPK1/MAPK3 signaling	2.276272e-01	0.643
R-HSA-9768759	Regulation of NPAS4 gene expression	7.953193e-02	1.099
R-HSA-2172127	DAP12 interactions	3.002712e-01	0.522
R-HSA-9022692	Regulation of MECP2 expression and activity	5.064082e-02	1.295
R-HSA-9909648	Regulation of PD-L1(CD274) expression	2.191013e-01	0.659
R-HSA-68875	Mitotic Prophase	3.144241e-01	0.502
R-HSA-112310	Neurotransmitter release cycle	1.589970e-01	0.799
R-HSA-418990	Adherens junctions interactions	3.166097e-02	1.499
R-HSA-9909396	Circadian clock	1.438340e-02	1.842
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	9.054247e-02	1.043
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	1.528242e-01	0.816
R-HSA-421270	Cell-cell junction organization	6.446187e-02	1.191
R-HSA-376172	DSCAM interactions	8.099784e-02	1.092
R-HSA-8857538	PTK6 promotes HIF1A stabilization	1.731069e-01	0.762
R-HSA-9675151	Disorders of Developmental Biology	7.344840e-02	1.134
R-HSA-69416	Dimerization of procaspase-8	2.073189e-01	0.683
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN...	2.401193e-01	0.620
R-HSA-1483226	Synthesis of PI	2.560085e-01	0.592
R-HSA-9623433	NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	2.715664e-01	0.566
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	3.163205e-01	0.500
R-HSA-1980143	Signaling by NOTCH1	1.039945e-01	0.983
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	3.583325e-01	0.446
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	1.528242e-01	0.816
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	3.157313e-01	0.501
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	1.628591e-01	0.788
R-HSA-389948	Co-inhibition by PD-1	3.179329e-01	0.498
R-HSA-9764265	Regulation of CDH1 Expression and Function	2.227363e-02	1.652
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	2.227363e-02	1.652
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	1.628591e-01	0.788
R-HSA-74752	Signaling by Insulin receptor	3.649604e-01	0.438
R-HSA-68877	Mitotic Prometaphase	2.924107e-01	0.534
R-HSA-9018519	Estrogen-dependent gene expression	1.079278e-01	0.967
R-HSA-8941326	RUNX2 regulates bone development	2.303662e-01	0.638
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	1.749147e-01	0.757
R-HSA-8853884	Transcriptional Regulation by VENTX	2.692056e-01	0.570
R-HSA-9839373	Signaling by TGFBR3	1.075015e-01	0.969
R-HSA-199991	Membrane Trafficking	2.514776e-01	0.600
R-HSA-8949215	Mitochondrial calcium ion transport	1.120344e-01	0.951
R-HSA-429914	Deadenylation-dependent mRNA decay	1.697545e-01	0.770
R-HSA-9766229	Degradation of CDH1	3.387684e-01	0.470
R-HSA-8878159	Transcriptional regulation by RUNX3	2.844992e-02	1.546
R-HSA-388841	Regulation of T cell activation by CD28 family	2.312692e-01	0.636
R-HSA-201681	TCF dependent signaling in response to WNT	6.726679e-02	1.172
R-HSA-5683057	MAPK family signaling cascades	9.220363e-02	1.035
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	3.234333e-01	0.490
R-HSA-195721	Signaling by WNT	1.396293e-01	0.855
R-HSA-5654743	Signaling by FGFR4	2.925186e-01	0.534
R-HSA-9818749	Regulation of NFE2L2 gene expression	1.731069e-01	0.762
R-HSA-525793	Myogenesis	3.109328e-02	1.507
R-HSA-198753	ERK/MAPK targets	1.052841e-01	0.978
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	1.545729e-01	0.811
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	3.163205e-01	0.500
R-HSA-4839726	Chromatin organization	3.419625e-01	0.466
R-HSA-5654741	Signaling by FGFR3	3.080097e-01	0.511
R-HSA-1500931	Cell-Cell communication	2.812878e-02	1.551
R-HSA-74160	Gene expression (Transcription)	2.271625e-01	0.644
R-HSA-1295596	Spry regulation of FGF signaling	3.306207e-01	0.481
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	2.267415e-01	0.644
R-HSA-2559585	Oncogene Induced Senescence	6.046391e-02	1.219
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	1.052841e-01	0.978
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	1.052841e-01	0.978
R-HSA-427652	Sodium-coupled phosphate cotransporters	1.554528e-01	0.808
R-HSA-5660668	CLEC7A/inflammasome pathway	1.554528e-01	0.808
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	5.080910e-02	1.294
R-HSA-426117	Cation-coupled Chloride cotransporters	1.903930e-01	0.720
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	2.073189e-01	0.683
R-HSA-201688	WNT mediated activation of DVL	2.238918e-01	0.650
R-HSA-877312	Regulation of IFNG signaling	2.867999e-01	0.542
R-HSA-418457	cGMP effects	3.163205e-01	0.500
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	3.306207e-01	0.481
R-HSA-9706369	Negative regulation of FLT3	3.446226e-01	0.463
R-HSA-9634600	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	3.446226e-01	0.463
R-HSA-187687	Signalling to ERKs	2.226339e-01	0.652
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	2.381156e-01	0.623
R-HSA-163615	PKA activation	3.849003e-01	0.415
R-HSA-68886	M Phase	3.473710e-01	0.459
R-HSA-73857	RNA Polymerase II Transcription	2.223772e-01	0.653
R-HSA-6794362	Protein-protein interactions at synapses	4.891680e-02	1.311
R-HSA-1643713	Signaling by EGFR in Cancer	1.472755e-01	0.832
R-HSA-212436	Generic Transcription Pathway	1.664511e-01	0.779
R-HSA-3214842	HDMs demethylate histones	1.400522e-01	0.854
R-HSA-1251985	Nuclear signaling by ERBB4	2.614268e-01	0.583
R-HSA-3214841	PKMTs methylate histone lysines	8.252192e-02	1.083
R-HSA-5637810	Constitutive Signaling by EGFRvIII	7.953193e-02	1.099
R-HSA-5637812	Signaling by EGFRvIII in Cancer	7.953193e-02	1.099
R-HSA-9768777	Regulation of NPAS4 gene transcription	2.238918e-01	0.650
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	1.209658e-01	0.917
R-HSA-8876725	Protein methylation	3.306207e-01	0.481
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	3.446226e-01	0.463
R-HSA-5635838	Activation of SMO	3.446226e-01	0.463
R-HSA-9664420	Killing mechanisms	3.446226e-01	0.463
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	3.583325e-01	0.446
R-HSA-4086398	Ca2+ pathway	2.452883e-01	0.610
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	8.493725e-02	1.071
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	1.067871e-01	0.971
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	6.046391e-02	1.219
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	4.803677e-02	1.318
R-HSA-9762293	Regulation of CDH11 gene transcription	2.238918e-01	0.650
R-HSA-5689896	Ovarian tumor domain proteases	2.381156e-01	0.623
R-HSA-8853659	RET signaling	6.392195e-02	1.194
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	2.308896e-02	1.637
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	1.374228e-01	0.862
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	1.554528e-01	0.808
R-HSA-9758919	Epithelial-Mesenchymal Transition (EMT) during gastrulation	1.554528e-01	0.808
R-HSA-9764302	Regulation of CDH19 Expression and Function	1.554528e-01	0.808
R-HSA-193692	Regulated proteolysis of p75NTR	2.238918e-01	0.650
R-HSA-448706	Interleukin-1 processing	2.238918e-01	0.650
R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	2.560085e-01	0.592
R-HSA-9005891	Loss of function of MECP2 in Rett syndrome	2.867999e-01	0.542
R-HSA-9005895	Pervasive developmental disorders	2.867999e-01	0.542
R-HSA-9697154	Disorders of Nervous System Development	2.867999e-01	0.542
R-HSA-8949664	Processing of SMDT1	3.017157e-01	0.520
R-HSA-5655291	Signaling by FGFR4 in disease	3.163205e-01	0.500
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	1.126194e-01	0.948
R-HSA-9006931	Signaling by Nuclear Receptors	1.156647e-01	0.937
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	1.097644e-01	0.960
R-HSA-449147	Signaling by Interleukins	2.928001e-01	0.533
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	1.919632e-01	0.717
R-HSA-9006936	Signaling by TGFB family members	3.714675e-02	1.430
R-HSA-9701898	STAT3 nuclear events downstream of ALK signaling	6.177020e-02	1.209
R-HSA-9707564	Cytoprotection by HMOX1	3.019939e-01	0.520
R-HSA-5357801	Programmed Cell Death	1.071731e-01	0.970
R-HSA-3247509	Chromatin modifying enzymes	2.917911e-01	0.535
R-HSA-157118	Signaling by NOTCH	3.116819e-01	0.506
R-HSA-170834	Signaling by TGF-beta Receptor Complex	8.079963e-02	1.093
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	6.511332e-02	1.186
R-HSA-8848021	Signaling by PTK6	6.511332e-02	1.186
R-HSA-9700206	Signaling by ALK in cancer	1.097644e-01	0.960
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	3.109328e-02	1.507
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	2.867999e-01	0.542
R-HSA-9818030	NFE2L2 regulating tumorigenic genes	3.017157e-01	0.520
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	3.306207e-01	0.481
R-HSA-388844	Receptor-type tyrosine-protein phosphatases	3.446226e-01	0.463
R-HSA-975577	N-Glycan antennae elongation	3.446226e-01	0.463
R-HSA-9679191	Potential therapeutics for SARS	1.476525e-01	0.831
R-HSA-109704	PI3K Cascade	3.463968e-01	0.460
R-HSA-2262752	Cellular responses to stress	3.545783e-01	0.450
R-HSA-418346	Platelet homeostasis	2.401992e-01	0.619
R-HSA-8878166	Transcriptional regulation by RUNX2	3.097025e-01	0.509
R-HSA-975155	MyD88 dependent cascade initiated on endosome	1.155098e-01	0.937
R-HSA-389356	Co-stimulation by CD28	3.311131e-01	0.480
R-HSA-975871	MyD88 cascade initiated on plasma membrane	2.004604e-01	0.698
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	2.004604e-01	0.698
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	2.004604e-01	0.698
R-HSA-163765	ChREBP activates metabolic gene expression	3.589540e-02	1.445
R-HSA-170968	Frs2-mediated activation	3.017157e-01	0.520
R-HSA-193639	p75NTR signals via NF-kB	3.306207e-01	0.481
R-HSA-9612973	Autophagy	3.073931e-01	0.512
R-HSA-8953897	Cellular responses to stimuli	3.377289e-01	0.471
R-HSA-5687128	MAPK6/MAPK4 signaling	3.134455e-01	0.504
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	2.072377e-01	0.684
R-HSA-9692914	SARS-CoV-1-host interactions	1.069454e-01	0.971
R-HSA-2559583	Cellular Senescence	6.286632e-02	1.202
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	1.374228e-01	0.862
R-HSA-8934903	Receptor Mediated Mitophagy	2.401193e-01	0.620
R-HSA-982772	Growth hormone receptor signaling	1.258545e-01	0.900
R-HSA-5687613	Diseases associated with surfactant metabolism	2.867999e-01	0.542
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	3.306207e-01	0.481
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	1.274197e-01	0.895
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	1.367062e-01	0.864
R-HSA-163685	Integration of energy metabolism	2.241693e-01	0.649
R-HSA-187037	Signaling by NTRK1 (TRKA)	1.872499e-01	0.728
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	2.925186e-01	0.534
R-HSA-5218920	VEGFR2 mediated vascular permeability	2.692056e-01	0.570
R-HSA-9816359	Maternal to zygotic transition (MZT)	3.286239e-01	0.483
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	1.693658e-01	0.771
R-HSA-450294	MAP kinase activation	1.801183e-01	0.744
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	3.311131e-01	0.480
R-HSA-201556	Signaling by ALK	7.482637e-02	1.126
R-HSA-1483191	Synthesis of PC	3.234333e-01	0.490
R-HSA-9860931	Response of endothelial cells to shear stress	2.267415e-01	0.644
R-HSA-448424	Interleukin-17 signaling	2.286043e-01	0.641
R-HSA-430116	GP1b-IX-V activation signalling	2.238918e-01	0.650
R-HSA-8963896	HDL assembly	3.163205e-01	0.500
R-HSA-432142	Platelet sensitization by LDL	3.849003e-01	0.415
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	1.853636e-01	0.732
R-HSA-1489509	DAG and IP3 signaling	3.080097e-01	0.511
R-HSA-9856651	MITF-M-dependent gene expression	2.830350e-01	0.548
R-HSA-109581	Apoptosis	3.922352e-02	1.406
R-HSA-9827857	Specification of primordial germ cells	7.953193e-02	1.099
R-HSA-2586552	Signaling by Leptin	2.401193e-01	0.620
R-HSA-1433557	Signaling by SCF-KIT	9.467022e-02	1.024
R-HSA-9842663	Signaling by LTK	2.867999e-01	0.542
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	3.017157e-01	0.520
R-HSA-9855142	Cellular responses to mechanical stimuli	2.768971e-01	0.558
R-HSA-166520	Signaling by NTRKs	1.420107e-01	0.848
R-HSA-9958790	SLC-mediated transport of inorganic anions	2.458782e-01	0.609
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	8.576602e-02	1.067
R-HSA-9634815	Transcriptional Regulation by NPAS4	3.615641e-01	0.442
R-HSA-435354	Zinc transporters	3.163205e-01	0.500
R-HSA-9733709	Cardiogenesis	1.995829e-01	0.700
R-HSA-75153	Apoptotic execution phase	2.856393e-02	1.544
R-HSA-8983711	OAS antiviral response	2.867999e-01	0.542
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	3.615641e-01	0.442
R-HSA-4420097	VEGFA-VEGFR2 Pathway	2.908958e-01	0.536
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	4.194167e-02	1.377
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	3.446226e-01	0.463
R-HSA-9945266	Differentiation of T cells	3.446226e-01	0.463
R-HSA-9679506	SARS-CoV Infections	1.636092e-01	0.786
R-HSA-194138	Signaling by VEGF	3.428602e-01	0.465
R-HSA-1592230	Mitochondrial biogenesis	1.462837e-01	0.835
R-HSA-109582	Hemostasis	3.423648e-01	0.466
R-HSA-9678108	SARS-CoV-1 Infection	2.291886e-01	0.640
R-HSA-1059683	Interleukin-6 signaling	3.017157e-01	0.520
R-HSA-9682706	Replication of the SARS-CoV-1 genome	3.017157e-01	0.520
R-HSA-9694686	Replication of the SARS-CoV-2 genome	3.717564e-01	0.430
R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	3.163205e-01	0.500
R-HSA-72702	Ribosomal scanning and start codon recognition	3.914852e-01	0.407
R-HSA-5578775	Ion homeostasis	3.914852e-01	0.407
R-HSA-5654736	Signaling by FGFR1	3.914852e-01	0.407
R-HSA-5607764	CLEC7A (Dectin-1) signaling	3.933454e-01	0.405
R-HSA-5654710	PI-3K cascade:FGFR3	3.977700e-01	0.400
R-HSA-113510	E2F mediated regulation of DNA replication	3.977700e-01	0.400
R-HSA-8964058	HDL remodeling	3.977700e-01	0.400
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	3.977700e-01	0.400
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	3.977700e-01	0.400
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	3.977700e-01	0.400
R-HSA-1480926	O2/CO2 exchange in erythrocytes	3.977700e-01	0.400
R-HSA-9834899	Specification of the neural plate border	3.977700e-01	0.400
R-HSA-1912420	Pre-NOTCH Processing in Golgi	3.977700e-01	0.400
R-HSA-844456	The NLRP3 inflammasome	3.977700e-01	0.400
R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	3.977700e-01	0.400
R-HSA-9764561	Regulation of CDH1 Function	3.988689e-01	0.399
R-HSA-112399	IRS-mediated signalling	3.988689e-01	0.399
R-HSA-2980766	Nuclear Envelope Breakdown	3.988689e-01	0.399
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	4.062106e-01	0.391
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	4.062106e-01	0.391
R-HSA-9909620	Regulation of PD-L1(CD274) translation	4.103712e-01	0.387
R-HSA-5654720	PI-3K cascade:FGFR4	4.103712e-01	0.387
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	4.103712e-01	0.387
R-HSA-389513	Co-inhibition by CTLA4	4.103712e-01	0.387
R-HSA-194441	Metabolism of non-coding RNA	4.135091e-01	0.384
R-HSA-191859	snRNP Assembly	4.135091e-01	0.384
R-HSA-70171	Glycolysis	4.158184e-01	0.381
R-HSA-1227986	Signaling by ERBB2	4.207627e-01	0.376
R-HSA-983189	Kinesins	4.207627e-01	0.376
R-HSA-5602498	MyD88 deficiency (TLR2/4)	4.227095e-01	0.374
R-HSA-9939291	Matriglycan biosynthesis on DAG1	4.227095e-01	0.374
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ...	4.227095e-01	0.374
R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	4.227095e-01	0.374
R-HSA-111931	PKA-mediated phosphorylation of CREB	4.227095e-01	0.374
R-HSA-9819196	Zygotic genome activation (ZGA)	4.227095e-01	0.374
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	4.269562e-01	0.370
R-HSA-2559580	Oxidative Stress Induced Senescence	4.269562e-01	0.370
R-HSA-112043	PLC beta mediated events	4.279703e-01	0.369
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	4.347904e-01	0.362
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	4.347904e-01	0.362
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	4.347904e-01	0.362
R-HSA-175474	Assembly Of The HIV Virion	4.347904e-01	0.362
R-HSA-9671555	Signaling by PDGFR in disease	4.347904e-01	0.362
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	4.351305e-01	0.361
R-HSA-162599	Late Phase of HIV Life Cycle	4.372958e-01	0.359
R-HSA-212165	Epigenetic regulation of gene expression	4.376979e-01	0.359
R-HSA-111885	Opioid Signalling	4.380189e-01	0.359
R-HSA-8856828	Clathrin-mediated endocytosis	4.419425e-01	0.355
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	4.422423e-01	0.354
R-HSA-380259	Loss of Nlp from mitotic centrosomes	4.422423e-01	0.354
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	4.435202e-01	0.353
R-HSA-5619507	Activation of HOX genes during differentiation	4.435202e-01	0.353
R-HSA-5654689	PI-3K cascade:FGFR1	4.466191e-01	0.350
R-HSA-350054	Notch-HLH transcription pathway	4.466191e-01	0.350
R-HSA-912694	Regulation of IFNA/IFNB signaling	4.466191e-01	0.350
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	4.466191e-01	0.350
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specif...	4.466191e-01	0.350
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	4.466191e-01	0.350
R-HSA-189200	Cellular hexose transport	4.466191e-01	0.350
R-HSA-74751	Insulin receptor signalling cascade	4.493045e-01	0.347
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	4.493045e-01	0.347
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	4.563160e-01	0.341
R-HSA-112316	Neuronal System	4.581423e-01	0.339
R-HSA-8943723	Regulation of PTEN mRNA translation	4.582010e-01	0.339
R-HSA-912526	Interleukin receptor SHC signaling	4.582010e-01	0.339
R-HSA-9937008	Mitochondrial mRNA modification	4.582010e-01	0.339
R-HSA-8854691	Interleukin-20 family signaling	4.582010e-01	0.339
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	4.582010e-01	0.339
R-HSA-8939211	ESR-mediated signaling	4.590020e-01	0.338
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	4.599193e-01	0.337
R-HSA-8854518	AURKA Activation by TPX2	4.632760e-01	0.334
R-HSA-2672351	Stimuli-sensing channels	4.653075e-01	0.332
R-HSA-933542	TRAF6 mediated NF-kB activation	4.695413e-01	0.328
R-HSA-5621575	CD209 (DC-SIGN) signaling	4.695413e-01	0.328
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	4.695413e-01	0.328
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	4.695413e-01	0.328
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	4.695413e-01	0.328
R-HSA-429947	Deadenylation of mRNA	4.695413e-01	0.328
R-HSA-9836573	Mitochondrial RNA degradation	4.695413e-01	0.328
R-HSA-5669034	TNFs bind their physiological receptors	4.695413e-01	0.328
R-HSA-8963898	Plasma lipoprotein assembly	4.695413e-01	0.328
R-HSA-8863678	Neurodegenerative Diseases	4.695413e-01	0.328
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	4.695413e-01	0.328
R-HSA-6783589	Interleukin-6 family signaling	4.695413e-01	0.328
R-HSA-112040	G-protein mediated events	4.701834e-01	0.328
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	4.770375e-01	0.321
R-HSA-5654695	PI-3K cascade:FGFR2	4.806448e-01	0.318
R-HSA-9932451	SWI/SNF chromatin remodelers	4.806448e-01	0.318
R-HSA-9932444	ATP-dependent chromatin remodelers	4.806448e-01	0.318
R-HSA-5218921	VEGFR2 mediated cell proliferation	4.806448e-01	0.318
R-HSA-1482801	Acyl chain remodelling of PS	4.806448e-01	0.318
R-HSA-1187000	Fertilization	4.806448e-01	0.318
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	4.838374e-01	0.315
R-HSA-5653656	Vesicle-mediated transport	4.856116e-01	0.314
R-HSA-204005	COPII-mediated vesicle transport	4.905825e-01	0.309
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	4.905825e-01	0.309
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	4.915166e-01	0.308
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	4.915166e-01	0.308
R-HSA-1912422	Pre-NOTCH Expression and Processing	4.920006e-01	0.308
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	4.922012e-01	0.308
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	4.972720e-01	0.303
R-HSA-9006925	Intracellular signaling by second messengers	4.973029e-01	0.303
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	5.021615e-01	0.299
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	5.021615e-01	0.299
R-HSA-73863	RNA Polymerase I Transcription Termination	5.021615e-01	0.299
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	5.021615e-01	0.299
R-HSA-201451	Signaling by BMP	5.021615e-01	0.299
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	5.021615e-01	0.299
R-HSA-5655332	Signaling by FGFR3 in disease	5.021615e-01	0.299
R-HSA-75109	Triglyceride biosynthesis	5.021615e-01	0.299
R-HSA-389357	CD28 dependent PI3K/Akt signaling	5.021615e-01	0.299
R-HSA-1483213	Synthesis of PE	5.021615e-01	0.299
R-HSA-9006115	Signaling by NTRK2 (TRKB)	5.021615e-01	0.299
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	5.021615e-01	0.299
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	5.039053e-01	0.298
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	5.039291e-01	0.298
R-HSA-376176	Signaling by ROBO receptors	5.039291e-01	0.298
R-HSA-162587	HIV Life Cycle	5.055884e-01	0.296
R-HSA-167287	HIV elongation arrest and recovery	5.125841e-01	0.290
R-HSA-167290	Pausing and recovery of HIV elongation	5.125841e-01	0.290
R-HSA-5654732	Negative regulation of FGFR3 signaling	5.125841e-01	0.290
R-HSA-77387	Insulin receptor recycling	5.125841e-01	0.290
R-HSA-622312	Inflammasomes	5.125841e-01	0.290
R-HSA-2871809	FCERI mediated Ca+2 mobilization	5.128757e-01	0.290
R-HSA-1226099	Signaling by FGFR in disease	5.170011e-01	0.287
R-HSA-1236394	Signaling by ERBB4	5.170011e-01	0.287
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	5.227892e-01	0.282
R-HSA-5654733	Negative regulation of FGFR4 signaling	5.227892e-01	0.282
R-HSA-5654708	Downstream signaling of activated FGFR3	5.227892e-01	0.282
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	5.227892e-01	0.282
R-HSA-180024	DARPP-32 events	5.227892e-01	0.282
R-HSA-70326	Glucose metabolism	5.231420e-01	0.281
R-HSA-1169408	ISG15 antiviral mechanism	5.234626e-01	0.281
R-HSA-5688426	Deubiquitination	5.238896e-01	0.281
R-HSA-2219528	PI3K/AKT Signaling in Cancer	5.282307e-01	0.277
R-HSA-9020591	Interleukin-12 signaling	5.298659e-01	0.276
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	5.327813e-01	0.273
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	5.327813e-01	0.273
R-HSA-5654716	Downstream signaling of activated FGFR4	5.327813e-01	0.273
R-HSA-888590	GABA synthesis, release, reuptake and degradation	5.327813e-01	0.273
R-HSA-8863795	Downregulation of ERBB2 signaling	5.327813e-01	0.273
R-HSA-112311	Neurotransmitter clearance	5.327813e-01	0.273
R-HSA-114452	Activation of BH3-only proteins	5.327813e-01	0.273
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	5.425647e-01	0.266
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	5.425647e-01	0.266
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	5.425647e-01	0.266
R-HSA-186763	Downstream signal transduction	5.425647e-01	0.266
R-HSA-9730414	MITF-M-regulated melanocyte development	5.464792e-01	0.262
R-HSA-9659379	Sensory processing of sound	5.487227e-01	0.261
R-HSA-8931838	DAG1 glycosylations	5.521438e-01	0.258
R-HSA-9675126	Diseases of mitotic cell cycle	5.521438e-01	0.258
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	5.532139e-01	0.257
R-HSA-5654738	Signaling by FGFR2	5.548895e-01	0.256
R-HSA-6798695	Neutrophil degranulation	5.556361e-01	0.255
R-HSA-1855170	IPs transport between nucleus and cytosol	5.615230e-01	0.251
R-HSA-159227	Transport of the SLBP independent Mature mRNA	5.615230e-01	0.251
R-HSA-5675482	Regulation of necroptotic cell death	5.615230e-01	0.251
R-HSA-1839124	FGFR1 mutant receptor activation	5.615230e-01	0.251
R-HSA-5654726	Negative regulation of FGFR1 signaling	5.615230e-01	0.251
R-HSA-2022854	Keratan sulfate biosynthesis	5.615230e-01	0.251
R-HSA-176187	Activation of ATR in response to replication stress	5.615230e-01	0.251
R-HSA-9930044	Nuclear RNA decay	5.615230e-01	0.251
R-HSA-397795	G-protein beta:gamma signalling	5.615230e-01	0.251
R-HSA-354192	Integrin signaling	5.615230e-01	0.251
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	5.707062e-01	0.244
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	5.707062e-01	0.244
R-HSA-114508	Effects of PIP2 hydrolysis	5.707062e-01	0.244
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	5.707062e-01	0.244
R-HSA-5689880	Ub-specific processing proteases	5.782078e-01	0.238
R-HSA-1852241	Organelle biogenesis and maintenance	5.784006e-01	0.238
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	5.789574e-01	0.237
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	5.796977e-01	0.237
R-HSA-5654727	Negative regulation of FGFR2 signaling	5.796977e-01	0.237
R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	5.796977e-01	0.237
R-HSA-180746	Nuclear import of Rev protein	5.796977e-01	0.237
R-HSA-168638	NOD1/2 Signaling Pathway	5.796977e-01	0.237
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	5.796977e-01	0.237
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	5.796977e-01	0.237
R-HSA-5205647	Mitophagy	5.796977e-01	0.237
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	5.822893e-01	0.235
R-HSA-112315	Transmission across Chemical Synapses	5.876296e-01	0.231
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	5.885014e-01	0.230
R-HSA-5654696	Downstream signaling of activated FGFR2	5.885014e-01	0.230
R-HSA-5654687	Downstream signaling of activated FGFR1	5.885014e-01	0.230
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	5.906296e-01	0.229
R-HSA-141424	Amplification of signal from the kinetochores	5.906296e-01	0.229
R-HSA-199418	Negative regulation of the PI3K/AKT network	5.915090e-01	0.228
R-HSA-1474165	Reproduction	5.961449e-01	0.225
R-HSA-381038	XBP1(S) activates chaperone genes	5.963750e-01	0.224
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	5.971213e-01	0.224
R-HSA-111933	Calmodulin induced events	5.971213e-01	0.224
R-HSA-111997	CaM pathway	5.971213e-01	0.224
R-HSA-74158	RNA Polymerase III Transcription	5.971213e-01	0.224
R-HSA-114604	GPVI-mediated activation cascade	5.971213e-01	0.224
R-HSA-6804757	Regulation of TP53 Degradation	5.971213e-01	0.224
R-HSA-9682385	FLT3 signaling in disease	5.971213e-01	0.224
R-HSA-447115	Interleukin-12 family signaling	6.020598e-01	0.220
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	6.050824e-01	0.218
R-HSA-180910	Vpr-mediated nuclear import of PICs	6.055611e-01	0.218
R-HSA-427359	SIRT1 negatively regulates rRNA expression	6.055611e-01	0.218
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	6.055611e-01	0.218
R-HSA-549127	SLC-mediated transport of organic cations	6.055611e-01	0.218
R-HSA-9645723	Diseases of programmed cell death	6.076842e-01	0.216
R-HSA-9663891	Selective autophagy	6.076842e-01	0.216
R-HSA-9824443	Parasitic Infection Pathways	6.115057e-01	0.214
R-HSA-9658195	Leishmania infection	6.115057e-01	0.214
R-HSA-5213460	RIPK1-mediated regulated necrosis	6.138246e-01	0.212
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	6.138246e-01	0.212
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	6.187516e-01	0.208
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	6.219155e-01	0.206
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	6.219155e-01	0.206
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	6.219155e-01	0.206
R-HSA-168276	NS1 Mediated Effects on Host Pathways	6.219155e-01	0.206
R-HSA-3781860	Diseases associated with N-glycosylation of proteins	6.219155e-01	0.206
R-HSA-6806003	Regulation of TP53 Expression and Degradation	6.219155e-01	0.206
R-HSA-9675108	Nervous system development	6.225687e-01	0.206
R-HSA-1912408	Pre-NOTCH Transcription and Translation	6.241948e-01	0.205
R-HSA-3858494	Beta-catenin independent WNT signaling	6.276277e-01	0.202
R-HSA-69275	G2/M Transition	6.294455e-01	0.201
R-HSA-381070	IRE1alpha activates chaperones	6.295777e-01	0.201
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	6.298373e-01	0.201
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	6.298373e-01	0.201
R-HSA-3371568	Attenuation phase	6.298373e-01	0.201
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	6.298373e-01	0.201
R-HSA-202433	Generation of second messenger molecules	6.298373e-01	0.201
R-HSA-167169	HIV Transcription Elongation	6.298373e-01	0.201
R-HSA-177243	Interactions of Rev with host cellular proteins	6.298373e-01	0.201
R-HSA-176033	Interactions of Vpr with host cellular proteins	6.298373e-01	0.201
R-HSA-9646399	Aggrephagy	6.298373e-01	0.201
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	6.298373e-01	0.201
R-HSA-156842	Eukaryotic Translation Elongation	6.349007e-01	0.197
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	6.349007e-01	0.197
R-HSA-453274	Mitotic G2-G2/M phases	6.369668e-01	0.196
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	6.375937e-01	0.195
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	6.375937e-01	0.195
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	6.375937e-01	0.195
R-HSA-9694548	Maturation of spike protein	6.375937e-01	0.195
R-HSA-9607240	FLT3 Signaling	6.375937e-01	0.195
R-HSA-983712	Ion channel transport	6.406902e-01	0.193
R-HSA-9664407	Parasite infection	6.448453e-01	0.191
R-HSA-9664417	Leishmania phagocytosis	6.448453e-01	0.191
R-HSA-9664422	FCGR3A-mediated phagocytosis	6.448453e-01	0.191
R-HSA-9656223	Signaling by RAF1 mutants	6.451880e-01	0.190
R-HSA-5674135	MAP2K and MAPK activation	6.451880e-01	0.190
R-HSA-9932298	Degradation of CRY and PER proteins	6.451880e-01	0.190
R-HSA-442660	SLC-mediated transport of neurotransmitters	6.451880e-01	0.190
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	6.451880e-01	0.190
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	6.451880e-01	0.190
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	6.453670e-01	0.190
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	6.490610e-01	0.188
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	6.505107e-01	0.187
R-HSA-422475	Axon guidance	6.512667e-01	0.186
R-HSA-73762	RNA Polymerase I Transcription Initiation	6.526236e-01	0.185
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	6.526236e-01	0.185
R-HSA-111996	Ca-dependent events	6.526236e-01	0.185
R-HSA-1257604	PIP3 activates AKT signaling	6.548020e-01	0.184
R-HSA-1483257	Phospholipid metabolism	6.548020e-01	0.184
R-HSA-72689	Formation of a pool of free 40S subunits	6.555951e-01	0.183
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	6.573856e-01	0.182
R-HSA-72163	mRNA Splicing - Major Pathway	6.589320e-01	0.181
R-HSA-6807878	COPI-mediated anterograde transport	6.606204e-01	0.180
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	6.606204e-01	0.180
R-HSA-69231	Cyclin D associated events in G1	6.670319e-01	0.176
R-HSA-69236	G1 Phase	6.670319e-01	0.176
R-HSA-3214858	RMTs methylate histone arginines	6.670319e-01	0.176
R-HSA-3928662	EPHB-mediated forward signaling	6.670319e-01	0.176
R-HSA-5683826	Surfactant metabolism	6.670319e-01	0.176
R-HSA-190236	Signaling by FGFR	6.704945e-01	0.174
R-HSA-422356	Regulation of insulin secretion	6.704945e-01	0.174
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	6.740110e-01	0.171
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	6.740110e-01	0.171
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	6.740110e-01	0.171
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	6.740110e-01	0.171
R-HSA-69613	p53-Independent G1/S DNA Damage Checkpoint	6.740110e-01	0.171
R-HSA-69601	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	6.740110e-01	0.171
R-HSA-76009	Platelet Aggregation (Plug Formation)	6.740110e-01	0.171
R-HSA-199977	ER to Golgi Anterograde Transport	6.775733e-01	0.169
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	6.799865e-01	0.167
R-HSA-69618	Mitotic Spindle Checkpoint	6.801354e-01	0.167
R-HSA-72165	mRNA Splicing - Minor Pathway	6.808443e-01	0.167
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	6.808443e-01	0.167
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	6.808443e-01	0.167
R-HSA-9649948	Signaling downstream of RAS mutants	6.808443e-01	0.167
R-HSA-6802949	Signaling by RAS mutants	6.808443e-01	0.167
R-HSA-2299718	Condensation of Prophase Chromosomes	6.808443e-01	0.167
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	6.808443e-01	0.167
R-HSA-9861718	Regulation of pyruvate metabolism	6.808443e-01	0.167
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	6.808443e-01	0.167
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	6.808443e-01	0.167
R-HSA-9020702	Interleukin-1 signaling	6.848690e-01	0.164
R-HSA-9758941	Gastrulation	6.853989e-01	0.164
R-HSA-948021	Transport to the Golgi and subsequent modification	6.868004e-01	0.163
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	6.875347e-01	0.163
R-HSA-1483255	PI Metabolism	6.895452e-01	0.161
R-HSA-1483206	Glycerophospholipid biosynthesis	6.901689e-01	0.161
R-HSA-8963899	Plasma lipoprotein remodeling	6.940853e-01	0.159
R-HSA-70263	Gluconeogenesis	6.940853e-01	0.159
R-HSA-425410	Metal ion SLC transporters	6.940853e-01	0.159
R-HSA-72172	mRNA Splicing	6.968289e-01	0.157
R-HSA-1638074	Keratan sulfate/keratin metabolism	7.004990e-01	0.155
R-HSA-157858	Gap junction trafficking and regulation	7.004990e-01	0.155
R-HSA-9833110	RSV-host interactions	7.032325e-01	0.153
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	7.043416e-01	0.152
R-HSA-1280215	Cytokine Signaling in Immune system	7.063856e-01	0.151
R-HSA-5655253	Signaling by FGFR2 in disease	7.067786e-01	0.151
R-HSA-9824446	Viral Infection Pathways	7.111806e-01	0.148
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	7.129269e-01	0.147
R-HSA-211000	Gene Silencing by RNA	7.164153e-01	0.145
R-HSA-72187	mRNA 3'-end processing	7.189466e-01	0.143
R-HSA-112382	Formation of RNA Pol II elongation complex	7.189466e-01	0.143
R-HSA-73772	RNA Polymerase I Promoter Escape	7.189466e-01	0.143
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	7.206992e-01	0.142
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	7.206992e-01	0.142
R-HSA-75955	RNA Polymerase II Transcription Elongation	7.248405e-01	0.140
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	7.248405e-01	0.140
R-HSA-8956320	Nucleotide biosynthesis	7.248405e-01	0.140
R-HSA-9639288	Amino acids regulate mTORC1	7.248405e-01	0.140
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	7.249285e-01	0.140
R-HSA-9711123	Cellular response to chemical stress	7.280654e-01	0.138
R-HSA-202403	TCR signaling	7.291037e-01	0.137
R-HSA-2467813	Separation of Sister Chromatids	7.395967e-01	0.131
R-HSA-109606	Intrinsic Pathway for Apoptosis	7.417929e-01	0.130
R-HSA-76002	Platelet activation, signaling and aggregation	7.442966e-01	0.128
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	7.472091e-01	0.127
R-HSA-9772572	Early SARS-CoV-2 Infection Events	7.525119e-01	0.123
R-HSA-8979227	Triglyceride metabolism	7.577038e-01	0.121
R-HSA-72737	Cap-dependent Translation Initiation	7.606063e-01	0.119
R-HSA-72613	Eukaryotic Translation Initiation	7.606063e-01	0.119
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	7.627871e-01	0.118
R-HSA-8873719	RAB geranylgeranylation	7.627871e-01	0.118
R-HSA-8943724	Regulation of PTEN gene transcription	7.627871e-01	0.118
R-HSA-1660661	Sphingolipid de novo biosynthesis	7.627871e-01	0.118
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	7.627871e-01	0.118
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	7.627871e-01	0.118
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	7.627871e-01	0.118
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	7.627871e-01	0.118
R-HSA-2644603	Signaling by NOTCH1 in Cancer	7.627871e-01	0.118
R-HSA-5621481	C-type lectin receptors (CLRs)	7.653397e-01	0.116
R-HSA-162906	HIV Infection	7.660873e-01	0.116
R-HSA-73856	RNA Polymerase II Transcription Termination	7.677641e-01	0.115
R-HSA-168325	Viral Messenger RNA Synthesis	7.677641e-01	0.115
R-HSA-8939902	Regulation of RUNX2 expression and activity	7.677641e-01	0.115
R-HSA-1442490	Collagen degradation	7.677641e-01	0.115
R-HSA-9705683	SARS-CoV-2-host interactions	7.687971e-01	0.114
R-HSA-6784531	tRNA processing in the nucleus	7.726370e-01	0.112
R-HSA-9616222	Transcriptional regulation of granulopoiesis	7.726370e-01	0.112
R-HSA-186797	Signaling by PDGF	7.726370e-01	0.112
R-HSA-373755	Semaphorin interactions	7.774079e-01	0.109
R-HSA-69615	G1/S DNA Damage Checkpoints	7.774079e-01	0.109
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	7.786477e-01	0.109
R-HSA-9759194	Nuclear events mediated by NFE2L2	7.786477e-01	0.109
R-HSA-936837	Ion transport by P-type ATPases	7.820789e-01	0.107
R-HSA-1234174	Cellular response to hypoxia	7.866523e-01	0.104
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	7.866523e-01	0.104
R-HSA-162909	Host Interactions of HIV factors	7.888932e-01	0.103
R-HSA-9694516	SARS-CoV-2 Infection	7.920639e-01	0.101
R-HSA-69278	Cell Cycle, Mitotic	7.952922e-01	0.099
R-HSA-196807	Nicotinate metabolism	7.955139e-01	0.099
R-HSA-167172	Transcription of the HIV genome	7.998060e-01	0.097
R-HSA-5218859	Regulated Necrosis	7.998060e-01	0.097
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	7.998060e-01	0.097
R-HSA-114608	Platelet degranulation	8.019040e-01	0.096
R-HSA-75105	Fatty acyl-CoA biosynthesis	8.081228e-01	0.093
R-HSA-69202	Cyclin E associated events during G1/S transition	8.081228e-01	0.093
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	8.121511e-01	0.090
R-HSA-427413	NoRC negatively regulates rRNA expression	8.121511e-01	0.090
R-HSA-3000178	ECM proteoglycans	8.121511e-01	0.090
R-HSA-5632684	Hedgehog 'on' state	8.121511e-01	0.090
R-HSA-9638482	Metal ion assimilation from the host	8.121511e-01	0.090
R-HSA-453276	Regulation of mitotic cell cycle	8.121511e-01	0.090
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	8.121511e-01	0.090
R-HSA-5578749	Transcriptional regulation by small RNAs	8.160950e-01	0.088
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	8.160950e-01	0.088
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	8.160950e-01	0.088
R-HSA-5576891	Cardiac conduction	8.171654e-01	0.088
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	8.199564e-01	0.086
R-HSA-8856688	Golgi-to-ER retrograde transport	8.200888e-01	0.086
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	8.229703e-01	0.085
R-HSA-674695	RNA Polymerase II Pre-transcription Events	8.237369e-01	0.084
R-HSA-3000171	Non-integrin membrane-ECM interactions	8.274383e-01	0.082
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	8.274383e-01	0.082
R-HSA-73854	RNA Polymerase I Promoter Clearance	8.310622e-01	0.080
R-HSA-5689603	UCH proteinases	8.310622e-01	0.080
R-HSA-9694635	Translation of Structural Proteins	8.346102e-01	0.079
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	8.367660e-01	0.077
R-HSA-73864	RNA Polymerase I Transcription	8.380839e-01	0.077
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	8.380839e-01	0.077
R-HSA-69620	Cell Cycle Checkpoints	8.391569e-01	0.076
R-HSA-5358351	Signaling by Hedgehog	8.394060e-01	0.076
R-HSA-6807070	PTEN Regulation	8.420074e-01	0.075
R-HSA-381119	Unfolded Protein Response (UPR)	8.420074e-01	0.075
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	8.448145e-01	0.073
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	8.448145e-01	0.073
R-HSA-1632852	Macroautophagy	8.470961e-01	0.072
R-HSA-5693607	Processing of DNA double-strand break ends	8.480745e-01	0.072
R-HSA-416476	G alpha (q) signalling events	8.508493e-01	0.070
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	8.512662e-01	0.070
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	8.512662e-01	0.070
R-HSA-8957322	Metabolism of steroids	8.525495e-01	0.069
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	8.543910e-01	0.068
R-HSA-2871837	FCERI mediated NF-kB activation	8.568298e-01	0.067
R-HSA-168256	Immune System	8.583593e-01	0.066
R-HSA-6802957	Oncogenic MAPK signaling	8.604457e-01	0.065
R-HSA-1280218	Adaptive Immune System	8.654552e-01	0.063
R-HSA-8953854	Metabolism of RNA	8.679690e-01	0.061
R-HSA-70268	Pyruvate metabolism	8.690602e-01	0.061
R-HSA-156902	Peptide chain elongation	8.718122e-01	0.060
R-HSA-9755511	KEAP1-NFE2L2 pathway	8.725140e-01	0.059
R-HSA-1236974	ER-Phagosome pathway	8.745065e-01	0.058
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	8.746213e-01	0.058
R-HSA-446652	Interleukin-1 family signaling	8.746213e-01	0.058
R-HSA-68882	Mitotic Anaphase	8.757685e-01	0.058
R-HSA-425407	SLC-mediated transmembrane transport	8.765849e-01	0.057
R-HSA-202424	Downstream TCR signaling	8.771444e-01	0.057
R-HSA-2555396	Mitotic Metaphase and Anaphase	8.775511e-01	0.057
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	8.797270e-01	0.056
R-HSA-1266738	Developmental Biology	8.803501e-01	0.055
R-HSA-5663205	Infectious disease	8.809508e-01	0.055
R-HSA-9610379	HCMV Late Events	8.846850e-01	0.053
R-HSA-2682334	EPH-Ephrin signaling	8.847309e-01	0.053
R-HSA-9772573	Late SARS-CoV-2 Infection Events	8.847309e-01	0.053
R-HSA-5633007	Regulation of TP53 Activity	8.903598e-01	0.050
R-HSA-2168880	Scavenging of heme from plasma	8.941245e-01	0.049
R-HSA-8957275	Post-translational protein phosphorylation	9.006652e-01	0.045
R-HSA-5619102	SLC transporter disorders	9.026093e-01	0.045
R-HSA-9614085	FOXO-mediated transcription	9.027546e-01	0.044
R-HSA-192105	Synthesis of bile acids and bile salts	9.027546e-01	0.044
R-HSA-1640170	Cell Cycle	9.046283e-01	0.044
R-HSA-5610787	Hedgehog 'off' state	9.048002e-01	0.043
R-HSA-9842860	Regulation of endogenous retroelements	9.087636e-01	0.042
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	9.087636e-01	0.042
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	9.144023e-01	0.039
R-HSA-168249	Innate Immune System	9.190932e-01	0.037
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	9.213838e-01	0.036
R-HSA-1236975	Antigen processing-Cross presentation	9.213838e-01	0.036
R-HSA-194068	Bile acid and bile salt metabolism	9.246586e-01	0.034
R-HSA-9609646	HCMV Infection	9.249581e-01	0.034
R-HSA-2871796	FCERI mediated MAPK activation	9.277973e-01	0.033
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	9.277973e-01	0.033
R-HSA-927802	Nonsense-Mediated Decay (NMD)	9.277973e-01	0.033
R-HSA-1483249	Inositol phosphate metabolism	9.277973e-01	0.033
R-HSA-3781865	Diseases of glycosylation	9.284968e-01	0.032
R-HSA-983169	Class I MHC mediated antigen processing & presentation	9.294373e-01	0.032
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	9.308057e-01	0.031
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	9.322627e-01	0.030
R-HSA-5628897	TP53 Regulates Metabolic Genes	9.336891e-01	0.030
R-HSA-2029485	Role of phospholipids in phagocytosis	9.350855e-01	0.029
R-HSA-909733	Interferon alpha/beta signaling	9.350855e-01	0.029
R-HSA-5617833	Cilium Assembly	9.355775e-01	0.029
R-HSA-382551	Transport of small molecules	9.387184e-01	0.027
R-HSA-5693538	Homology Directed Repair	9.391013e-01	0.027
R-HSA-9609690	HCMV Early Events	9.419916e-01	0.026
R-HSA-9717207	Sensory perception of sweet, bitter, and umami (glutamate) taste	9.452514e-01	0.024
R-HSA-2132295	MHC class II antigen presentation	9.452514e-01	0.024
R-HSA-6809371	Formation of the cornified envelope	9.464050e-01	0.024
R-HSA-69206	G1/S Transition	9.486400e-01	0.023
R-HSA-9664323	FCGR3A-mediated IL10 synthesis	9.497224e-01	0.022
R-HSA-388396	GPCR downstream signalling	9.499302e-01	0.022
R-HSA-69481	G2/M Checkpoints	9.507820e-01	0.022
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	9.542853e-01	0.020
R-HSA-9717189	Sensory perception of taste	9.557554e-01	0.020
R-HSA-1474228	Degradation of the extracellular matrix	9.566883e-01	0.019
R-HSA-397014	Muscle contraction	9.570336e-01	0.019
R-HSA-72766	Translation	9.617162e-01	0.017
R-HSA-5173105	O-linked glycosylation	9.618876e-01	0.017
R-HSA-9948299	Ribosome-associated quality control	9.626915e-01	0.017
R-HSA-1643685	Disease	9.679586e-01	0.014
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	9.688711e-01	0.014
R-HSA-453279	Mitotic G1 phase and G1/S transition	9.692068e-01	0.014
R-HSA-69242	S Phase	9.704930e-01	0.013
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	9.717256e-01	0.012
R-HSA-913531	Interferon Signaling	9.719206e-01	0.012
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	9.729069e-01	0.012
R-HSA-2142753	Arachidonate metabolism	9.729069e-01	0.012
R-HSA-5693532	DNA Double-Strand Break Repair	9.734789e-01	0.012
R-HSA-168273	Influenza Viral RNA Transcription and Replication	9.745871e-01	0.011
R-HSA-9824439	Bacterial Infection Pathways	9.747251e-01	0.011
R-HSA-9711097	Cellular response to starvation	9.761634e-01	0.010
R-HSA-877300	Interferon gamma signaling	9.766669e-01	0.010
R-HSA-3700989	Transcriptional Regulation by TP53	9.768358e-01	0.010
R-HSA-5619115	Disorders of transmembrane transporters	9.771264e-01	0.010
R-HSA-372790	Signaling by GPCR	9.794861e-01	0.009
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	9.819420e-01	0.008
R-HSA-72306	tRNA processing	9.819420e-01	0.008
R-HSA-418555	G alpha (s) signalling events	9.823237e-01	0.008
R-HSA-9734767	Developmental Cell Lineages	9.829368e-01	0.007
R-HSA-9664433	Leishmania parasite growth and survival	9.830632e-01	0.007
R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	9.830632e-01	0.007
R-HSA-446203	Asparagine N-linked glycosylation	9.845143e-01	0.007
R-HSA-168255	Influenza Infection	9.851016e-01	0.007
R-HSA-8868773	rRNA processing in the nucleus and cytosol	9.877097e-01	0.005
R-HSA-1630316	Glycosaminoglycan metabolism	9.889565e-01	0.005
R-HSA-428157	Sphingolipid metabolism	9.906942e-01	0.004
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	9.907865e-01	0.004
R-HSA-9640148	Infection with Enterobacteria	9.910842e-01	0.004
R-HSA-6805567	Keratinization	9.918161e-01	0.004
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	9.928030e-01	0.003
R-HSA-8951664	Neddylation	9.940654e-01	0.003
R-HSA-418594	G alpha (i) signalling events	9.943951e-01	0.002
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	9.950008e-01	0.002
R-HSA-1474244	Extracellular matrix organization	9.952234e-01	0.002
R-HSA-72312	rRNA processing	9.953123e-01	0.002
R-HSA-15869	Metabolism of nucleotides	9.956978e-01	0.002
R-HSA-5668914	Diseases of metabolism	9.960500e-01	0.002
R-HSA-196854	Metabolism of vitamins and cofactors	9.974595e-01	0.001
R-HSA-556833	Metabolism of lipids	9.979580e-01	0.001
R-HSA-8978868	Fatty acid metabolism	9.989176e-01	0.000
R-HSA-1428517	Aerobic respiration and respiratory electron transport	9.995512e-01	0.000
R-HSA-73894	DNA Repair	9.997023e-01	0.000
R-HSA-597592	Post-translational protein modification	9.998894e-01	0.000
R-HSA-392499	Metabolism of proteins	9.999997e-01	0.000
R-HSA-9709957	Sensory Perception	1.000000e+00	0.000
R-HSA-1430728	Metabolism	1.000000e+00	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
MARK3	0.838	0.590	4	0.537
MARK4	0.835	0.517	4	0.424
MARK2	0.834	0.582	4	0.517
QSK	0.833	0.491	4	0.460
SIK	0.823	0.399	-3	0.851
MARK1	0.823	0.506	4	0.477
CLK3	0.822	0.120	1	0.879
AMPKA1	0.822	0.338	-3	0.917
CDC7	0.820	0.068	1	0.878
COT	0.819	0.009	2	0.843
AMPKA2	0.818	0.304	-3	0.901
NUAK2	0.817	0.208	-3	0.916
NDR2	0.817	0.079	-3	0.907
HIPK4	0.817	0.178	1	0.852
PIM3	0.817	0.091	-3	0.913
BRSK1	0.814	0.277	-3	0.883
TSSK1	0.814	0.280	-3	0.929
CDKL1	0.812	0.121	-3	0.894
CAMK1B	0.812	0.130	-3	0.919
QIK	0.812	0.328	-3	0.894
MOS	0.812	0.059	1	0.900
SRPK1	0.811	0.117	-3	0.863
MTOR	0.811	-0.008	1	0.840
SKMLCK	0.811	0.124	-2	0.903
RSK2	0.811	0.097	-3	0.874
RAF1	0.809	0.051	1	0.883
NLK	0.809	0.076	1	0.891
BRSK2	0.808	0.276	-3	0.889
CDKL5	0.808	0.111	-3	0.892
PRKD1	0.807	0.067	-3	0.905
NDR1	0.807	0.071	-3	0.906
PRKD2	0.806	0.089	-3	0.875
PRPK	0.806	-0.071	-1	0.880
PIM1	0.806	0.093	-3	0.877
NUAK1	0.806	0.217	-3	0.880
ATR	0.806	0.037	1	0.868
SRPK2	0.805	0.119	-3	0.799
P90RSK	0.805	0.088	-3	0.879
TSSK2	0.805	0.206	-5	0.885
WNK1	0.805	0.067	-2	0.906
RSK3	0.804	0.092	-3	0.873
IKKB	0.804	-0.044	-2	0.777
CLK2	0.804	0.132	-3	0.856
TBK1	0.803	0.010	1	0.781
ICK	0.803	0.106	-3	0.917
PDHK4	0.803	-0.074	1	0.892
DAPK2	0.802	0.097	-3	0.920
PKN3	0.802	0.040	-3	0.908
HUNK	0.802	0.082	2	0.756
MST4	0.802	0.032	2	0.829
CAMK2G	0.802	-0.047	2	0.804
PKACG	0.802	0.073	-2	0.794
LATS2	0.802	0.033	-5	0.813
CAMLCK	0.801	0.082	-2	0.882
GRK1	0.801	0.025	-2	0.858
SSTK	0.801	0.328	4	0.387
CAMK2B	0.801	0.035	2	0.796
NIK	0.800	0.070	-3	0.915
CAMK2A	0.800	0.044	2	0.802
NIM1	0.800	0.152	3	0.776
PKN2	0.800	0.045	-3	0.904
FAM20C	0.800	0.077	2	0.706
MAPKAPK2	0.800	0.069	-3	0.842
ERK5	0.799	0.025	1	0.854
AURC	0.799	0.072	-2	0.705
IKKE	0.799	-0.020	1	0.780
SRPK3	0.798	0.100	-3	0.833
CAMK2D	0.798	0.012	-3	0.903
MAPKAPK3	0.798	0.061	-3	0.874
P70S6KB	0.798	0.066	-3	0.885
RSK4	0.798	0.097	-3	0.854
GSK3A	0.798	-0.013	4	0.056
DYRK2	0.798	0.102	1	0.773
GCN2	0.797	-0.097	2	0.758
BMPR2	0.797	-0.086	-2	0.898
CLK4	0.797	0.106	-3	0.864
GSK3B	0.797	-0.039	4	0.055
DSTYK	0.797	-0.061	2	0.873
MSK1	0.797	0.084	-3	0.858
PKACB	0.796	0.094	-2	0.725
KIS	0.796	0.053	1	0.761
CLK1	0.796	0.115	-3	0.851
PRKX	0.795	0.102	-3	0.803
TGFBR2	0.795	-0.017	-2	0.817
LATS1	0.795	0.067	-3	0.906
WNK3	0.795	0.015	1	0.850
PKCD	0.795	0.040	2	0.748
RIPK3	0.795	-0.018	3	0.726
PDHK1	0.795	-0.095	1	0.876
MELK	0.794	0.153	-3	0.888
BCKDK	0.794	-0.066	-1	0.809
MYLK4	0.794	0.109	-2	0.817
MSK2	0.794	0.063	-3	0.850
PRKD3	0.793	0.090	-3	0.854
ATM	0.792	0.024	1	0.810
HIPK2	0.792	0.111	1	0.688
HIPK1	0.792	0.126	1	0.781
ULK2	0.792	-0.119	2	0.737
IKKA	0.791	-0.042	-2	0.769
CAMK1G	0.791	0.151	-3	0.856
CDK7	0.791	0.055	1	0.749
NEK6	0.790	-0.088	-2	0.869
NEK7	0.790	-0.086	-3	0.843
GRK6	0.790	-0.055	1	0.871
BMPR1B	0.790	0.066	1	0.832
CAMK4	0.790	0.035	-3	0.886
AURB	0.789	0.067	-2	0.703
GRK5	0.789	-0.127	-3	0.841
CDK8	0.788	0.040	1	0.735
AKT2	0.788	0.095	-3	0.812
DYRK1A	0.788	0.114	1	0.807
PAK1	0.788	0.024	-2	0.826
MLK1	0.788	-0.080	2	0.779
CHAK2	0.788	-0.056	-1	0.858
PKG2	0.787	0.070	-2	0.723
SGK3	0.787	0.089	-3	0.872
PKCB	0.787	0.023	2	0.701
MASTL	0.787	-0.101	-2	0.841
PKCG	0.787	0.003	2	0.702
DYRK4	0.786	0.097	1	0.700
DNAPK	0.786	0.031	1	0.773
RIPK1	0.786	-0.047	1	0.829
MNK2	0.786	0.024	-2	0.828
PIM2	0.786	0.094	-3	0.856
TGFBR1	0.786	0.021	-2	0.835
DLK	0.785	-0.095	1	0.862
PAK3	0.785	0.015	-2	0.821
IRE1	0.785	-0.047	1	0.807
GRK7	0.784	0.019	1	0.804
PHKG1	0.784	0.023	-3	0.894
PKCA	0.784	0.004	2	0.693
CDK19	0.784	0.044	1	0.697
CDK18	0.784	0.049	1	0.676
CDK1	0.783	0.052	1	0.712
ANKRD3	0.783	-0.050	1	0.877
ALK4	0.783	-0.014	-2	0.858
P38A	0.783	0.071	1	0.775
CDK5	0.782	0.045	1	0.764
SNRK	0.782	0.070	2	0.644
PKACA	0.782	0.092	-2	0.671
MNK1	0.782	0.024	-2	0.836
JNK2	0.781	0.063	1	0.701
CHK1	0.781	0.063	-3	0.889
DYRK1B	0.781	0.102	1	0.726
PASK	0.781	0.064	-3	0.919
AURA	0.781	0.035	-2	0.675
DYRK3	0.781	0.108	1	0.782
HIPK3	0.780	0.089	1	0.786
DCAMKL1	0.780	0.076	-3	0.876
PAK2	0.780	0.024	-2	0.811
SMG1	0.780	-0.003	1	0.820
GRK4	0.780	-0.096	-2	0.869
NEK9	0.780	-0.111	2	0.790
P38B	0.780	0.077	1	0.710
PKCH	0.780	-0.003	2	0.680
MLK2	0.780	-0.103	2	0.782
ULK1	0.779	-0.138	-3	0.812
CAMK1D	0.779	0.123	-3	0.807
JNK3	0.779	0.053	1	0.730
PKR	0.779	-0.044	1	0.863
CDK13	0.778	0.023	1	0.722
PKCZ	0.778	-0.016	2	0.743
MEK1	0.778	-0.041	2	0.805
MLK3	0.778	-0.071	2	0.710
ALK2	0.777	-0.000	-2	0.844
PLK1	0.777	-0.075	-2	0.816
PAK6	0.777	0.014	-2	0.736
IRE2	0.776	-0.035	2	0.698
TTBK2	0.776	-0.102	2	0.658
CDK14	0.776	0.059	1	0.719
CDK10	0.776	0.070	1	0.704
CDK17	0.776	0.047	1	0.630
SMMLCK	0.776	0.068	-3	0.898
ERK1	0.776	0.054	1	0.700
VRK2	0.776	-0.099	1	0.893
AKT1	0.775	0.086	-3	0.828
NEK2	0.775	-0.035	2	0.777
PLK3	0.775	-0.031	2	0.754
P38G	0.775	0.061	1	0.626
ACVR2B	0.775	-0.005	-2	0.816
CDK12	0.775	0.034	1	0.698
CDK2	0.775	0.026	1	0.787
DAPK3	0.775	0.094	-3	0.886
CDK9	0.774	0.025	1	0.727
MAPKAPK5	0.774	0.006	-3	0.826
ACVR2A	0.773	-0.017	-2	0.798
YSK4	0.773	-0.076	1	0.812
CHAK1	0.773	-0.070	2	0.748
WNK4	0.773	-0.001	-2	0.891
DRAK1	0.773	-0.031	1	0.802
TLK2	0.772	-0.059	1	0.846
MST3	0.772	0.003	2	0.810
P70S6K	0.772	0.061	-3	0.822
ERK2	0.772	0.034	1	0.746
MAK	0.772	0.130	-2	0.774
GRK2	0.771	-0.020	-2	0.763
PHKG2	0.771	0.032	-3	0.873
CDK16	0.771	0.051	1	0.645
PRP4	0.771	0.036	-3	0.791
BMPR1A	0.770	0.028	1	0.809
DCAMKL2	0.770	0.044	-3	0.889
DAPK1	0.770	0.076	-3	0.875
MPSK1	0.770	0.035	1	0.789
CDK3	0.769	0.043	1	0.647
PKCT	0.769	0.006	2	0.686
CAMK1A	0.769	0.146	-3	0.783
SGK1	0.769	0.102	-3	0.750
MOK	0.766	0.123	1	0.787
CK1E	0.766	-0.013	-3	0.496
AKT3	0.766	0.089	-3	0.765
TAO3	0.766	-0.028	1	0.834
MEK5	0.765	-0.115	2	0.784
PKCE	0.765	0.029	2	0.688
MLK4	0.765	-0.113	2	0.685
BRAF	0.765	-0.067	-4	0.859
NEK5	0.765	-0.043	1	0.851
MRCKA	0.764	0.089	-3	0.852
PLK4	0.764	-0.055	2	0.576
PKCI	0.764	0.004	2	0.711
GAK	0.764	0.026	1	0.844
MEKK3	0.764	-0.090	1	0.837
TLK1	0.763	-0.050	-2	0.858
MRCKB	0.763	0.089	-3	0.846
IRAK4	0.763	-0.058	1	0.808
CHK2	0.763	0.083	-3	0.766
GCK	0.763	0.037	1	0.861
ROCK2	0.763	0.099	-3	0.881
MEKK1	0.762	-0.088	1	0.834
CK2A2	0.762	0.008	1	0.749
PAK5	0.762	0.019	-2	0.688
P38D	0.762	0.054	1	0.637
MEKK2	0.761	-0.070	2	0.757
PINK1	0.761	-0.104	1	0.854
HRI	0.761	-0.111	-2	0.855
PERK	0.760	-0.113	-2	0.843
JNK1	0.760	0.039	1	0.687
NEK11	0.760	-0.066	1	0.830
HPK1	0.759	0.044	1	0.845
ZAK	0.759	-0.128	1	0.803
LKB1	0.759	-0.014	-3	0.853
PKN1	0.759	0.043	-3	0.835
SBK	0.759	0.099	-3	0.713
ERK7	0.759	0.027	2	0.552
PAK4	0.758	0.015	-2	0.692
DMPK1	0.758	0.120	-3	0.858
TAO2	0.758	-0.047	2	0.810
CK1D	0.758	-0.008	-3	0.444
GRK3	0.757	-0.030	-2	0.730
NEK8	0.757	-0.060	2	0.779
PDK1	0.756	-0.003	1	0.816
CK2A1	0.756	-0.006	1	0.731
MEKK6	0.755	-0.040	1	0.832
CK1A2	0.755	-0.013	-3	0.448
CAMKK2	0.754	-0.068	-2	0.766
KHS2	0.753	0.042	1	0.853
CDK6	0.753	0.030	1	0.696
IRAK1	0.753	-0.092	-1	0.775
NEK4	0.753	-0.033	1	0.827
TNIK	0.753	-0.026	3	0.817
CK1G1	0.753	-0.046	-3	0.485
LRRK2	0.752	-0.039	2	0.814
KHS1	0.752	0.032	1	0.835
MINK	0.752	-0.027	1	0.837
TAK1	0.752	-0.011	1	0.871
CRIK	0.752	0.109	-3	0.832
CAMKK1	0.752	-0.124	-2	0.771
CDK4	0.752	0.028	1	0.686
MAP3K15	0.752	-0.037	1	0.792
PKG1	0.752	0.073	-2	0.636
PLK2	0.751	-0.035	-3	0.754
BUB1	0.751	0.045	-5	0.846
HGK	0.751	-0.033	3	0.818
ROCK1	0.751	0.099	-3	0.853
MST2	0.751	-0.043	1	0.854
LOK	0.750	-0.016	-2	0.798
TTBK1	0.749	-0.099	2	0.579
EEF2K	0.749	-0.067	3	0.808
VRK1	0.748	-0.053	2	0.788
NEK1	0.747	-0.028	1	0.824
MST1	0.745	-0.032	1	0.836
SLK	0.745	-0.039	-2	0.752
PBK	0.745	0.005	1	0.764
PDHK3_TYR	0.744	0.103	4	0.175
YSK1	0.742	-0.053	2	0.770
STK33	0.740	-0.094	2	0.579
MEK2	0.738	-0.118	2	0.764
PDHK4_TYR	0.738	0.084	2	0.865
RIPK2	0.736	-0.123	1	0.759
HASPIN	0.736	-0.002	-1	0.735
TESK1_TYR	0.734	-0.005	3	0.857
YANK3	0.734	-0.044	2	0.387
MAP2K4_TYR	0.733	-0.039	-1	0.896
MAP2K6_TYR	0.732	-0.037	-1	0.895
MAP2K7_TYR	0.732	0.009	2	0.830
TTK	0.732	-0.054	-2	0.838
BMPR2_TYR	0.731	-0.001	-1	0.888
NEK3	0.731	-0.096	1	0.782
PKMYT1_TYR	0.730	-0.027	3	0.821
LIMK2_TYR	0.730	0.012	-3	0.913
PDHK1_TYR	0.730	-0.014	-1	0.896
MYO3B	0.729	-0.053	2	0.792
OSR1	0.728	-0.095	2	0.760
TAO1	0.726	-0.060	1	0.761
MYO3A	0.725	-0.058	1	0.823
BIKE	0.725	-0.025	1	0.703
PINK1_TYR	0.725	-0.098	1	0.862
ASK1	0.725	-0.075	1	0.774
ALPHAK3	0.723	-0.069	-1	0.783
DDR1	0.722	-0.053	4	0.161
LIMK1_TYR	0.722	-0.056	2	0.816
EPHA6	0.721	-0.021	-1	0.855
RET	0.720	-0.082	1	0.833
CK1A	0.719	-0.038	-3	0.348
MST1R	0.716	-0.083	3	0.761
TXK	0.716	0.016	1	0.865
ROS1	0.716	-0.067	3	0.725
EPHB4	0.715	-0.066	-1	0.826
TYK2	0.715	-0.107	1	0.828
TYRO3	0.715	-0.082	3	0.748
FGR	0.714	-0.058	1	0.867
YES1	0.714	-0.051	-1	0.849
ABL2	0.713	-0.051	-1	0.809
FER	0.711	-0.082	1	0.892
JAK2	0.711	-0.110	1	0.826
BLK	0.711	0.027	-1	0.837
CSF1R	0.711	-0.087	3	0.738
TNK2	0.710	-0.060	3	0.707
LCK	0.710	-0.019	-1	0.836
INSRR	0.710	-0.075	3	0.713
EPHA4	0.710	-0.050	2	0.764
AAK1	0.710	-0.003	1	0.594
TNNI3K_TYR	0.709	-0.003	1	0.826
NEK10_TYR	0.709	-0.039	1	0.716
ABL1	0.709	-0.052	-1	0.804
JAK3	0.709	-0.094	1	0.807
STLK3	0.708	-0.116	1	0.779
HCK	0.708	-0.060	-1	0.835
TNK1	0.708	-0.046	3	0.731
SRMS	0.707	-0.075	1	0.875
DDR2	0.707	-0.017	3	0.703
FGFR2	0.706	-0.091	3	0.771
ITK	0.706	-0.064	-1	0.807
EPHB1	0.706	-0.083	1	0.868
JAK1	0.704	-0.049	1	0.775
TEK	0.704	-0.063	3	0.689
KDR	0.704	-0.073	3	0.712
BMX	0.703	-0.039	-1	0.732
TEC	0.703	-0.050	-1	0.742
PDGFRB	0.702	-0.124	3	0.760
EPHB3	0.702	-0.090	-1	0.808
EPHB2	0.702	-0.072	-1	0.801
KIT	0.702	-0.107	3	0.746
YANK2	0.701	-0.062	2	0.404
AXL	0.701	-0.097	3	0.732
MERTK	0.701	-0.085	3	0.728
MET	0.701	-0.085	3	0.731
FYN	0.701	-0.015	-1	0.818
FGFR1	0.700	-0.079	3	0.725
FLT3	0.700	-0.122	3	0.741
BTK	0.699	-0.104	-1	0.776
ALK	0.698	-0.090	3	0.675
WEE1_TYR	0.698	-0.086	-1	0.766
CK1G3	0.698	-0.044	-3	0.304
EPHA7	0.697	-0.078	2	0.757
LTK	0.696	-0.098	3	0.698
EPHA3	0.695	-0.106	2	0.729
EPHA1	0.695	-0.088	3	0.704
FGFR3	0.695	-0.087	3	0.740
PDGFRA	0.694	-0.162	3	0.753
FRK	0.694	-0.073	-1	0.837
PTK6	0.693	-0.147	-1	0.736
FLT1	0.693	-0.103	-1	0.822
ERBB2	0.693	-0.115	1	0.789
LYN	0.693	-0.070	3	0.670
PTK2B	0.692	-0.053	-1	0.777
PTK2	0.692	-0.007	-1	0.793
INSR	0.691	-0.116	3	0.682
NTRK1	0.691	-0.169	-1	0.811
EPHA5	0.689	-0.088	2	0.750
SRC	0.687	-0.069	-1	0.811
FLT4	0.687	-0.138	3	0.715
NTRK2	0.687	-0.151	3	0.714
MATK	0.687	-0.089	-1	0.734
EPHA8	0.685	-0.086	-1	0.795
CK1G2	0.684	-0.039	-3	0.400
SYK	0.684	-0.024	-1	0.775
NTRK3	0.683	-0.138	-1	0.764
EGFR	0.682	-0.084	1	0.690
FGFR4	0.680	-0.093	-1	0.761
CSK	0.679	-0.132	2	0.751
EPHA2	0.676	-0.094	-1	0.762
IGF1R	0.675	-0.123	3	0.629
ERBB4	0.673	-0.063	1	0.711
MUSK	0.670	-0.117	1	0.679
FES	0.663	-0.109	-1	0.709
ZAP70	0.658	-0.048	-1	0.710